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Aliases for TSPAN6 Gene

Aliases for TSPAN6 Gene

  • Tetraspanin 6 2 3
  • Transmembrane 4 Superfamily Member 6 2 3 4
  • Putative NF-Kappa-B-Activating Protein 321 3 4
  • Tetraspanin TM4-D 3 4
  • A15 Homolog 3 4
  • TSPAN-6 3 4
  • TM4SF6 3 4
  • Tetraspan TM4SF 3
  • T245 Protein 4
  • T245 3

External Ids for TSPAN6 Gene

Previous HGNC Symbols for TSPAN6 Gene

  • TM4SF6

Previous GeneCards Identifiers for TSPAN6 Gene

  • GC00U921554
  • GC0XM099690
  • GC0XM099886
  • GC0XM089683

Summaries for TSPAN6 Gene

Entrez Gene Summary for TSPAN6 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]

GeneCards Summary for TSPAN6 Gene

TSPAN6 (Tetraspanin 6) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TSPAN7.

Gene Wiki entry for TSPAN6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN6 Gene

Genomics for TSPAN6 Gene

Regulatory Elements for TSPAN6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSPAN6 Gene

100,627,108 bp from pter
100,639,991 bp from pter
12,884 bases
Minus strand

Genomic View for TSPAN6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN6 Gene

Proteins for TSPAN6 Gene

  • Protein details for TSPAN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q54A42
    • Q6IAN9

    Protein attributes for TSPAN6 Gene

    245 amino acids
    Molecular mass:
    27563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN6 Gene

Proteomics data for TSPAN6 Gene at MOPED

Post-translational modifications for TSPAN6 Gene

  • Glycosylation at Asn 134
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN6 Gene

Antibody Products

No data available for DME Specific Peptides for TSPAN6 Gene

Domains & Families for TSPAN6 Gene

Gene Families for TSPAN6 Gene

Suggested Antigen Peptide Sequences for TSPAN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN6: view

Function for TSPAN6 Gene

Gene Ontology (GO) - Molecular Function for TSPAN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 22908223
genes like me logo Genes that share ontologies with TSPAN6: view
genes like me logo Genes that share phenotypes with TSPAN6: view

Animal Model Products

miRNA for TSPAN6 Gene

miRTarBase miRNAs that target TSPAN6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN6 Gene

Localization for TSPAN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN6 Gene COMPARTMENTS Subcellular localization image for TSPAN6 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TSPAN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TSPAN6: view

Pathways & Interactions for TSPAN6 Gene

SuperPathways for TSPAN6 Gene

No Data Available

Interacting Proteins for TSPAN6 Gene

Gene Ontology (GO) - Biological Process for TSPAN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway IMP 22908223
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
GO:1901223 negative regulation of NIK/NF-kappaB signaling IDA 22908223
genes like me logo Genes that share ontologies with TSPAN6: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN6 Gene

Drugs & Compounds for TSPAN6 Gene

No Compound Related Data Available

Transcripts for TSPAN6 Gene

Unigene Clusters for TSPAN6 Gene

Tetraspanin 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: - -
SP5: -

Relevant External Links for TSPAN6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN6 Gene

mRNA expression in normal human tissues for TSPAN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPAN6 Gene

This gene is overexpressed in Nasal epithelium (46.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN6 Gene

SOURCE GeneReport for Unigene cluster for TSPAN6 Gene Hs.43233

genes like me logo Genes that share expression patterns with TSPAN6: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPAN6 Gene

Orthologs for TSPAN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN6 35
  • 92.38 (n)
  • 94.69 (a)
  • 95 (a)
(Canis familiaris)
Mammalia TSPAN6 35
  • 93.74 (n)
  • 94.69 (a)
  • 82 (a)
(Mus musculus)
Mammalia Tspan6 35
  • 87.48 (n)
  • 93.06 (a)
Tspan6 16
Tspan6 36
  • 93 (a)
(Pan troglodytes)
Mammalia TSPAN6 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan6 35
  • 88.16 (n)
  • 93.47 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN6 36
  • 62 (a)
(Gallus gallus)
Aves TSPAN6 35
  • 66.39 (n)
  • 68.16 (a)
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14973 35
tspan6 35
  • 69.39 (n)
  • 73.47 (a)
(Danio rerio)
Actinopterygii tspan7 35
  • 61.71 (n)
  • 59.92 (a)
tspan7 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005233 35
  • 45.7 (n)
  • 30.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp47F 35
  • 46.28 (n)
  • 31.7 (a)
(Caenorhabditis elegans)
Secernentea tsp-14 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7928 36
  • 34 (a)
Species with no ortholog for TSPAN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN6 Gene

Gene Tree for TSPAN6 (if available)
Gene Tree for TSPAN6 (if available)

Paralogs for TSPAN6 Gene

(14) SIMAP similar genes for TSPAN6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN6: view

Variants for TSPAN6 Gene

Sequence variations from dbSNP and Humsavar for TSPAN6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs8575 -- 100,629,831(+) AGCAC(A/G)GATCT utr-variant-3-prime
rs12151 -- 100,629,866(-) AGACC(C/T)AAAAC utr-variant-3-prime
rs12318 -- 100,629,287(+) ACAAC(C/T)TACAT utr-variant-3-prime
rs1018438 -- 100,631,654(+) TGTAT(A/G)CAACT intron-variant
rs1054594 -- 100,629,336(-) ACGAC(A/T)GGAAG utr-variant-3-prime

Variation tolerance for TSPAN6 Gene

Residual Variation Intolerance Score: 57.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSPAN6 Gene

Disorders for TSPAN6 Gene

Relevant External Links for TSPAN6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSPAN6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN6 Gene

Publications for TSPAN6 Gene

  1. Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22. (PMID: 9782095) Maeda K. … Niikawa N. (Genomics 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  4. Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner. (PMID: 22908223) Wang Y. … Ye X. (J. Biol. Chem. 2012) 67
  5. Identification of genomic deletions spanning the PCDH19 gene in two unrelated girls with intellectual disability and seizures. (PMID: 22091964) Vincent A.K. … Morel C.F. (Clin. Genet. 2012) 67

Products for TSPAN6 Gene

Sources for TSPAN6 Gene

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