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TSPAN6 Gene

protein-coding   GIFtS: 58
GCID: GC0XM099886

Tetraspanin 6

(Previous name: transmembrane 4 superfamily member 6)
(Previous symbol: TM4SF6)
  See TSPAN6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetraspanin 61 2     T2452
TM4SF61 2 3 5     TSPAN-62
Transmembrane 4 Superfamily Member 61 2 3     Tetraspan TM4SF2
Putative NF-Kappa-B-Activating Protein 3212 3     tetraspanin-62
Tetraspanin TM4-D2 3     Tspan-63
A15 Homolog2 3     T245 Protein3

External Ids:    HGNC: 118581   Entrez Gene: 71052   Ensembl: ENSG000000000037   OMIM: 3001915   UniProtKB: O436573   

Export aliases for TSPAN6 gene to outside databases

Previous GC identifers: GC00U921554 GC0XM099690 GC0XM089683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPAN6 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and
is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative
regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the
mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and
multiple transcript variants result from alternative splicing. (provided by RefSeq, Jul 2013)

GeneCards Summary for TSPAN6 Gene:
TSPAN6 (tetraspanin 6) is a protein-coding gene. Diseases associated with TSPAN6 include trichomoniasis. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is CD151.

Gene Wiki entry for TSPAN6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN6 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   Evi-1   E2F   E2F-1   POU2F1   POU2F1a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN6 promoter sequence
   Search Chromatin IP Primers for TSPAN6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22

TSPAN6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM099886:  view genomic region     (about GC identifiers)

Start:
99,883,667 bp from pter      End:
99,894,988 bp from pter
Size:
11,322 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSN6_HUMAN, O43657 (See protein sequence)
Recommended Name: Tetraspanin-6  
Size: 245 amino acids; 27563 Da
Secondary accessions: Q54A42 Q6IAN9

Explore the universe of human proteins at neXtProt for TSPAN6: NX_O43657

Explore proteomics data for TSPAN6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn134
  • Modification sites at PhosphoSitePlus

  • See TSPAN6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265669.1  NP_001265670.1  NP_001265671.1  NP_001265672.1  NP_003261.1  

    ENSEMBL proteins: 
     ENSP00000362111  

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    antibodies-online peptides for TSPAN6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry O43657

    ProtoNet protein and cluster: O43657

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN6_HUMAN, O43657
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with TSPAN6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
         
    Find genes that share ontologies with TSPAN6           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TSPAN6:
     Decreased TP53 protein express  Increased G1 DNA content  Increased cell size 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TSPAN6

    miRNA
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    miRTarBase miRNAs that target TSPAN6:
    hsa-mir-145-5p (MIRT021536), hsa-mir-124-3p (MIRT022561), hsa-mir-128-3p (MIRT021978), hsa-mir-132-3p (MIRT021861), hsa-mir-484 (MIRT042158), hsa-mir-142-3p (MIRT021618)

    Block miRNA regulation of human, mouse, rat TSPAN6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN6 (see all 10):
    hsa-miR-499-3p hsa-miR-1236 hsa-miR-3916 hsa-miR-3125 hsa-miR-335 hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN6_HUMAN, O43657: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with TSPAN6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN6
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for TSPAN6 (O436572, 3 ENSP000003621114) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMP19Q9Y3282, 3, ENSP000003077224MINT-8275655 I2D: score=2 STRING: ENSP00000307722
    CHD3Q128732, 3MINT-63160 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-63159 I2D: score=4 
    RIF1Q5UIP03I2D: score=1 
    ATP5OENSP000002902994STRING: ENSP00000290299
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IMP12761501
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with TSPAN6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN6 (TSN6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPAN6 gene (5 alternative transcripts): 
    NM_001278740.1  NM_001278741.1  NM_001278742.1  NM_001278743.1  NM_003270.3  

    Unigene Cluster for TSPAN6:

    Tetraspanin 6
    Hs.43233  [show with all ESTs]
    Unigene Representative Sequence: AB209876
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373020(uc004ega.1) ENST00000496771(uc010nna.1) ENST00000494424

    miRNA
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    Block miRNA regulation of human, mouse, rat TSPAN6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN6 (see all 10):
    hsa-miR-499-3p hsa-miR-1236 hsa-miR-3916 hsa-miR-3125 hsa-miR-335 hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN6
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN6
      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN6
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN6

    Additional mRNA sequence: 

    AB097016.1 AB209876.1 AF043906.1 AF053453.1 AF133426.1 AK075072.1 AK299176.1 AK300852.1 
    AK309581.1 AK315773.1 AY358825.1 BC012389.1 BT006977.1 CR457115.1 U84895.1 

    16 DOTS entries:

    DT.447633  DT.91760664  DT.95280397  DT.99954297  DT.121303539  DT.91760661  DT.102829840  DT.91760670 
    DT.100796807  DT.100796808  DT.121303466  DT.121303485  DT.121303549  DT.121303550  DT.121303547  DT.95280399 

    Selected AceView cDNA sequences (see all 334):

    H64001 AI282274 F04003 AW074856 AA846587 CR598720 AI690654 AA166985 
    BP375955 BX477322 BE777842 AW043707 CB984547 CA423555 AI538861 AW269975 
    AU102892 CR604634 AI633192 CA437477 BM818471 BX490535 AI313391 BM788758 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -                                                   
    SP2:              -     -                                                   
    SP3:                    -                       -                           
    SP4:                                                                        
    SP5:                                                        -               


    ECgene alternative splicing isoforms for TSPAN6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGATCGTT
    TSPAN6 Expression
    About this image


    TSPAN6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
             Oviduct
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Brain (Nervous System)
             Cerebral Cortex
    TSPAN6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43233
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan61 , 5 tetraspanin 61, 5 87.48(n)1
    93.06(a)1
      X (55.47 cM)5
    564961  NM_019656.31  NP_062630.21 
     1338910685 
    chicken
    (Gallus gallus)
    Aves TSPAN61 tetraspanin 6 66.39(n)
    68.16(a)
      422262  NM_001277603.1  NP_001264532.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.149732 Transcribed sequence with moderate similarity to protein more 74.25(n)    BX728638.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tspan71 tetraspanin 7 61.71(n)
    59.92(a)
      406802  NM_214774.1  NP_999939.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp47F1 Tetraspanin 47F 46.28(n)
    31.7(a)
      36230  NM_165828.2  NP_725044.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-146
    Protein TSP-14, isoform a (tsp-14) mRNA, complete ...
    13(a)
    1 → many
    X(4866683-4874657) WBGene00006640


    ENSEMBL Gene Tree for TSPAN6 (if available)
    TreeFam Gene Tree for TSPAN6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN6 gene
    CD1512  TSPAN52  TSPAN102  TSPAN172  TSPAN332  TSPAN32  CD632  TSPAN152  
    TSPAN72  TSPAN112  TSPAN142  ENSG000002503492  
    14 SIMAP similar genes for TSPAN6 using alignment to 1 protein entry:     TSN6_HUMAN:
    TM4SF2    TSPAN7    CD151    CD63    TSPAN1    TSPAN33
    TSPAN11    TSPAN9    TSPAN18    TSPAN3    TSPAN8    TM4SF9
    TSPAN5    CD82

    Find genes that share paralogs with TSPAN6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN6 (see all 175)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133475451,2
    C,F--99849477(+) AATAAT/CTCCAA 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1477908561,2
    --99849703(+) TTAATG/TTCCCT 1 -- ds50010--------
    rs1884966251,2
    --99849720(+) CTGAAG/TATACA 1 -- ds50010--------
    rs1417787481,2
    --99849759(+) AATGCA/GAACTA 1 -- ds50010--------
    rs1437538661,2
    C--99849775(+) TCAAAA/GAAGTC 1 -- ds50010--------
    rs1814081561,2
    --99850137(+) AAACAC/TGATCT 1 -- ut310--------
    rs1120753341,2
    C,F--99850286(+) TTCCAG/CTGAAT 1 -- ut311Minor allele frequency- C:0.00CSA 1
    rs1410961191,2
    --99850314(+) CAATTA/CCGACA 1 -- ut310--------
    rs123181,2
    C--99850404(-) ACAACT/CTACAT 1 -- ut313Minor allele frequency- C:0.00MN NA 188
    rs1502587921,2
    C--99850457(+) CAGTCA/GTGGAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TSPAN6 (99883667 - 99894988 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSPAN6: --
    Locus Specific Mutation Databases (LSDB): TSPAN6

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300191    OMIM disorders: --

    1 disease for TSPAN6:    
    About MalaCards
    trichomoniasis

    1 disease from the University of Copenhagen DISEASES database for TSPAN6:
    Trichomoniasis

    Find genes that share disorders with TSPAN6           About GenesLikeMe

    Genetic Association Database (GAD): TSPAN6

    Export disorders for TSPAN6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN6 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TSPAN6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22. (PubMed id 9782095)1, 2, 3 Maeda K.... Niikawa N. (Genomics 1998)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PubMed id 9714763)1, 2 Todd S.C.... Levy S. (Biochim. Biophys. Acta 1998)
    7. Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner. (PubMed id 22908223)1 Wang Y....Ye X. (J. Biol. Chem. 2012)
    8. Identification of genomic deletions spanning the PCDH19 gene in two unrelated girls with intellectual disability and seizures. (PubMed id 22091964)1 Vincent A.K....Morel C.F. (Clin. Genet. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7105 HGNC: 11858 AceView: TM4SF6 Ensembl:ENSG00000000003 euGenes: HUgn7105
    ECgene: TSPAN6 H-InvDB: TSPAN6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPAN6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPAN6 gene:
    Search GeneIP for patents involving TSPAN6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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