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TSPAN5 Gene

protein-coding   GIFtS: 53
GCID: GC04M099391

Tetraspanin 5

(Previous name: transmembrane 4 superfamily member 9)
(Previous symbol: TM4SF9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetraspanin 51 2     TSPAN-52
Transmembrane 4 Superfamily Member 91 2 3     Tetraspan 52
TM4SF91 2 3     Tetraspan TM4SF2
Tetraspan NET-42 3     tetraspanin-52
NET42 5     Transmembrane 4 Superfamily, Member 82
NET-42     Tspan-53

External Ids:    HGNC: 177531   Entrez Gene: 100982   Ensembl: ENSG000001687857   OMIM: 6131365   UniProtKB: P620793   

Export aliases for TSPAN5 gene to outside databases

Previous GC identifers: GC04M099751 GC04M099612 GC04M095128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPAN5 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSPAN5 Gene:
TSPAN5 (tetraspanin 5) is a protein-coding gene. An important paralog of this gene is CD151.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN5 gene promoter:
         NF-1   NF-1/L   Pbx1a   ATF-2   STAT5A   Nkx2-5   Gfi-1   FOXL1   GATA-6   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN5 promoter sequence
   Search Chromatin IP Primers for TSPAN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q23   Ensembl cytogenetic band:  4q23   HGNC cytogenetic band: 4q22.3

TSPAN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M099391:  view genomic region     (about GC identifiers)

Start:
99,391,518 bp from pter      End:
99,579,812 bp from pter
Size:
188,295 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSN5_HUMAN, P62079 (See protein sequence)
Recommended Name: Tetraspanin-5  
Size: 268 amino acids; 30337 Da
Secondary accessions: B2RDY2 O60628 O60746 Q6FHE5 Q9JLY1

Explore the universe of human proteins at neXtProt for TSPAN5: NX_P62079

Explore proteomics data for TSPAN5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn169, Asn174, Asn232
  • Modification sites at PhosphoSitePlus

  • See TSPAN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005714.2  
    ENSEMBL proteins: 
     ENSP00000421808   ENSP00000307701   ENSP00000423916   ENSP00000422351   ENSP00000423504  
     ENSP00000426248   ENSP00000422548  

    TSPAN5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TSPAN5

     
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    Search eBioscience for ELISAs for TSPAN5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P62079

    ProtoNet protein and cluster: P62079

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN5_HUMAN, P62079
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with TSPAN5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPAN5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSPAN5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPAN5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPAN5

    miRNA
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    miRTarBase miRNAs that target TSPAN5:
    hsa-mir-335-5p (MIRT018927)

    Block miRNA regulation of human, mouse, rat TSPAN5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN5 (see all 36):
    hsa-miR-513a-5p hsa-miR-15a hsa-miR-139-5p hsa-miR-3921 hsa-miR-218 hsa-miR-10b* hsa-miR-223 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSPAN5
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSPAN5

    Clone
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    OriGene clones in human, mouse for TSPAN5 (see all 7)
    OriGene ORF clones in mouse, rat for TSPAN5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN5 (NM_005723)
    Sino Biological Human cDNA Clone for TSPAN5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN5

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN5_HUMAN, P62079: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TSPAN5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN5
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TSPAN5 (ENSP000003077014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000215428ENSP000002774914STRING: ENSP00000277491
    HMCN1ENSP000002715884STRING: ENSP00000271588
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN5 (TSN5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPAN5 gene: 
    NM_005723.3  

    Unigene Cluster for TSPAN5:

    Tetraspanin 5
    Hs.118118  [show with all ESTs]
    Unigene Representative Sequence: AK126702
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508798 ENST00000305798(uc011cdz.2 uc003hub.3) ENST00000505184
    ENST00000511753 ENST00000515440 ENST00000509168 ENST00000515287 ENST00000511651
    ENST00000511800 ENST00000507167
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSPAN5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN5 (see all 36):
    hsa-miR-513a-5p hsa-miR-15a hsa-miR-139-5p hsa-miR-3921 hsa-miR-218 hsa-miR-10b* hsa-miR-223 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSPAN5
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN5
    Clone
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    OriGene clones in human, mouse for TSPAN5 (see all 7)
    OriGene ORF clones in mouse, rat for TSPAN5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN5 (NM_005723)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN5
    Primer
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    OriGene qPCR primer pairs and template standards for TSPAN5
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN5
      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN5
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN5

    Additional mRNA sequence: 

    AF065389.1 AK055659.1 AK126702.1 AK295385.1 AK315723.1 BC009704.1 CR541809.1 CR541829.1 

    9 DOTS entries:

    DT.455194  DT.101964212  DT.97774343  DT.100813151  DT.97794070  DT.86853310  DT.86857926  DT.92433806 
    DT.95165914 

    Selected AceView cDNA sequences (see all 255):

    AI474685 AI130031 BC009704 CA418233 NM_005723 BF059737 AI302454 BM667700 
    Z41856 N62391 BF476560 AI089708 Z38875 CA449579 BM714891 BQ686709 
    CA411747 CA448231 AA045201 AA548109 AW086460 AA058797 CB049344 CA423785 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                                   
    SP2:                    -           -     -                                 
    SP3:                    -     -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for TSPAN5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGACAC
    TSPAN5 Expression
    About this image


    TSPAN5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
    TSPAN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118118
        Custom PCR Arrays for TSPAN5
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan51 , 5 tetraspanin 51, 5 93.16(n)1
    100(a)1
      3 (64.42 cM)5
    562241  NM_019571.41  NP_062517.11 
     1387421955 
    chicken
    (Gallus gallus)
    Aves TSPAN51 tetraspanin 5 88.93(n)
    98.76(a)
      422702  XM_420654.4  XP_420654.3 
    lizard
    (Anolis carolinensis)
    Reptilia TSPAN56
    tetraspanin 5
    99(a)
    1 ↔ 1
    GL343307.1(1294117-1384367)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.218922 Xenopus laevis, Similar to transmembrane 4 superfamily more 79.73(n)    BC041304.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tspan5a1 tetraspanin 5a 79.15(n)
    91.39(a)
      450026  NM_001006047.1  NP_001006047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp26A6
    Tetraspanin 26A
    37(a)
    1 → many
    2L(6000228-6003738)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-121 tsp-12 50.84(n)
    47.1(a)
      177890  NM_069452.4  NP_501853.1 


    ENSEMBL Gene Tree for TSPAN5 (if available)
    TreeFam Gene Tree for TSPAN5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN5 gene
    CD1512  TSPAN102  TSPAN172  TSPAN332  TSPAN62  CD632  TSPAN32  TSPAN152  
    TSPAN72  TSPAN112  TSPAN142  ENSG000002503492  
    Selected SIMAP similar genes for TSPAN5 using alignment to 7 protein entries:     TSN5_HUMAN (see all proteins) (see all similar genes):
    TM4SF9    TM4SF17    TSPAN17    TSPAN14    TSPAN33    CD9
    BTCC-1    TSPAN18    TSPAN15    TSPAN4    CD151    CD82
    CD81    CD63    CD53    TSPAN10    TM4SF2    TSPAN6

    Find genes that share paralogs with TSPAN5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN5 (see all 3537)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105883451,2
    C--99291510(+) tcttt-/GAGT  
            
    ttcac
    1 -- int11Minor allele frequency- GAGT:0.00NA 2
    rs765735971,2
    C,F--99391036(+) AAACAT/CAGATT 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs2006705701,2
    C--99391301(-) GGCTTG/TTTTGG 1 -- ds50010--------
    rs1382154761,2
    --99391437(+) TTCTGA/TCACCT 1 -- ds50010--------
    rs1832954161,2
    --99391469(+) GATTCA/GAAAAT 1 -- ds50010--------
    rs1491528901,2
    C--99391546(+) TGACAA/GCCTTT 1 -- ut310--------
    rs1129683031,2
    C,F--99391613(+) CACTCG/TGACTT 1 -- ut312Minor allele frequency- T:0.04CSA WA 120
    rs1887911491,2
    --99391813(+) ATGAAA/GTAAGA 1 -- ut310--------
    rs1447899751,2
    C--99391831(+) ACAGTC/TGGAGT 1 -- ut310--------
    rs1386457071,2
    --99392010(+) AACCTC/TGCTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TSPAN5 (99391518 - 99579812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSPAN5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269762CNV Insertion20981092
    nsv879651CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPAN5
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613136    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TSPAN5:
    Intracranial aneurysm

    Find genes that share disorders with TSPAN5           About GenesLikeMe

    Genetic Association Database (GAD): TSPAN5
    Human Genome Epidemiology (HuGE) Navigator: TSPAN5 (1 document)

    Export disorders for TSPAN5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN5 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TSPAN5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PubMed id 9714763)1, 2 Todd S.C.... Levy S. (Biochim. Biophys. Acta 1998)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10098 HGNC: 17753 AceView: TM4SF9 Ensembl:ENSG00000168785 euGenes: HUgn10098
    ECgene: TSPAN5 H-InvDB: TSPAN5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPAN5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPAN5 gene:
    Search GeneIP for patents involving TSPAN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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