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Aliases for TSPAN5 Gene

Aliases for TSPAN5 Gene

  • Tetraspanin 5 2 3 5
  • Transmembrane 4 Superfamily Member 9 2 3 4
  • Tetraspan NET-4 3 4
  • TSPAN-5 3 4
  • TM4SF9 3 4
  • Transmembrane 4 Superfamily, Member 8 3
  • Tetraspan TM4SF 3
  • Tetraspan 5 3
  • NET-4 3
  • NET4 3

External Ids for TSPAN5 Gene

Previous HGNC Symbols for TSPAN5 Gene

  • TM4SF9

Previous GeneCards Identifiers for TSPAN5 Gene

  • GC04M099751
  • GC04M099612
  • GC04M099391
  • GC04M095128

Summaries for TSPAN5 Gene

Entrez Gene Summary for TSPAN5 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN5 Gene

TSPAN5 (Tetraspanin 5) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is ENSG00000250349.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN5 Gene

Genomics for TSPAN5 Gene

Regulatory Elements for TSPAN5 Gene

Enhancers for TSPAN5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN5 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN5 Gene

98,470,367 bp from pter
98,658,661 bp from pter
188,295 bases
Minus strand

Genomic View for TSPAN5 Gene

Genes around TSPAN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN5 Gene

Proteins for TSPAN5 Gene

  • Protein details for TSPAN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RDY2
    • O60628
    • O60746
    • Q6FHE5
    • Q9JLY1

    Protein attributes for TSPAN5 Gene

    268 amino acids
    Molecular mass:
    30337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN5 Gene

Proteomics data for TSPAN5 Gene at MOPED

Post-translational modifications for TSPAN5 Gene

  • Glycosylation at Asn 49, Asn 169, Asn 174, and Asn 232
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN5 Gene

No data available for DME Specific Peptides for TSPAN5 Gene

Domains & Families for TSPAN5 Gene

Gene Families for TSPAN5 Gene

Suggested Antigen Peptide Sequences for TSPAN5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN5: view

Function for TSPAN5 Gene

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN5

CRISPR Products

miRNA for TSPAN5 Gene

miRTarBase miRNAs that target TSPAN5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN5 Gene

Localization for TSPAN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN5 Gene COMPARTMENTS Subcellular localization image for TSPAN5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
genes like me logo Genes that share ontologies with TSPAN5: view

Pathways & Interactions for TSPAN5 Gene

SuperPathways for TSPAN5 Gene

No Data Available

Interacting Proteins for TSPAN5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000307701 for TSPAN5 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN5: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN5 Gene

Drugs & Compounds for TSPAN5 Gene

No Compound Related Data Available

Transcripts for TSPAN5 Gene

Unigene Clusters for TSPAN5 Gene

Tetraspanin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for TSPAN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN5 Gene

mRNA expression in normal human tissues for TSPAN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for TSPAN5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN5 Gene

SOURCE GeneReport for Unigene cluster for TSPAN5 Gene Hs.118118

genes like me logo Genes that share expression patterns with TSPAN5: view

Protein tissue co-expression partners for TSPAN5 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN5 Gene

Orthologs for TSPAN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN5 35
  • 94.53 (n)
  • 99.63 (a)
  • 100 (a)
(Canis familiaris)
Mammalia TSPAN5 35
  • 95.65 (n)
  • 99.63 (a)
  • 100 (a)
(Mus musculus)
Mammalia Tspan5 35
  • 93.16 (n)
  • 100 (a)
Tspan5 16
Tspan5 36
  • 100 (a)
(Pan troglodytes)
Mammalia TSPAN5 35
  • 99.88 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan5 35
  • 92.66 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia TSPAN5 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN5 36
  • 82 (a)
(Gallus gallus)
Aves TSPAN5 35
  • 88.93 (n)
  • 98.76 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia TSPAN5 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan5 35
  • 82.96 (n)
  • 95.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21892 35
(Danio rerio)
Actinopterygii tspan5a 35
  • 79.15 (n)
  • 91.39 (a)
tspan5a 36
  • 86 (a)
tspan5b 36
  • 85 (a)
tspan5b 36
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea tsp-12 35
  • 50.84 (n)
  • 47.1 (a)
tsp-12 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for TSPAN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN5 Gene

Gene Tree for TSPAN5 (if available)
Gene Tree for TSPAN5 (if available)

Paralogs for TSPAN5 Gene

genes like me logo Genes that share paralogs with TSPAN5: view

Variants for TSPAN5 Gene

Sequence variations from dbSNP and Humsavar for TSPAN5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3941 -- 98,627,031(+) GAAGC(A/G)TTGTA intron-variant
rs11145 -- 98,471,963(+) TACCA(C/T)CACAA nc-transcript-variant, utr-variant-3-prime
rs15746 -- 98,472,183(-) CTTCC(A/G)TAATT nc-transcript-variant, utr-variant-3-prime
rs846002 -- 98,541,352(+) TATAC(A/C)CTACA intron-variant
rs846003 -- 98,526,315(-) CCTGG(A/C)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN5 Gene

Variant ID Type Subtype PubMed ID
nsv879651 CNV Gain 21882294
esv269762 CNV Insertion 20981092

Variation tolerance for TSPAN5 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN5 Gene

Disorders for TSPAN5 Gene

Relevant External Links for TSPAN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN5 Gene

Publications for TSPAN5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E. … Rubinstein E. (J. Cell Biol. 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells. (PMID: 20220101) Dunn C.D. … Greenwald I. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23

Products for TSPAN5 Gene

Sources for TSPAN5 Gene