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Aliases for TSPAN5 Gene

Aliases for TSPAN5 Gene

  • Tetraspanin 5 2 3
  • Transmembrane 4 Superfamily Member 9 2 3 4
  • Tetraspan NET-4 3 4
  • TSPAN-5 3 4
  • TM4SF9 3 4
  • NET4 3 6
  • Transmembrane 4 Superfamily, Member 8 3
  • Tetraspan TM4SF 3
  • Tetraspanin-5 3
  • Tetraspan 5 3
  • NET-4 3

External Ids for TSPAN5 Gene

Previous HGNC Symbols for TSPAN5 Gene

  • TM4SF9

Previous GeneCards Identifiers for TSPAN5 Gene

  • GC04M099751
  • GC04M099612
  • GC04M099391
  • GC04M095128

Summaries for TSPAN5 Gene

Entrez Gene Summary for TSPAN5 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN5 Gene

TSPAN5 (Tetraspanin 5) is a Protein Coding gene. An important paralog of this gene is TSPAN7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN5 Gene

Genomics for TSPAN5 Gene

Regulatory Elements for TSPAN5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSPAN5 Gene

98,470,367 bp from pter
98,658,661 bp from pter
188,295 bases
Minus strand

Genomic View for TSPAN5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN5 Gene

Proteins for TSPAN5 Gene

  • Protein details for TSPAN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RDY2
    • O60628
    • O60746
    • Q6FHE5
    • Q9JLY1

    Protein attributes for TSPAN5 Gene

    268 amino acids
    Molecular mass:
    30337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN5 Gene

Proteomics data for TSPAN5 Gene at MOPED

Post-translational modifications for TSPAN5 Gene

  • Glycosylation at Asn49, Asn169, Asn174, and Asn232
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN5 Gene

No data available for DME Specific Peptides for TSPAN5 Gene

Domains for TSPAN5 Gene

Gene Families for TSPAN5 Gene


Suggested Antigen Peptide Sequences for TSPAN5 Gene

Graphical View of Domain Structure for InterPro Entry



  • P62079
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN5: view

Function for TSPAN5 Gene

Gene Ontology (GO) - Molecular Function for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN5: view

Animal Model Products

CRISPR Products

miRNA for TSPAN5 Gene

miRTarBase miRNAs that target TSPAN5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSPAN5 Gene

Localization for TSPAN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN5 Gene COMPARTMENTS Subcellular localization image for TSPAN5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN5: view

Pathways for TSPAN5 Gene

SuperPathways for TSPAN5 Gene

No Data Available

Interacting Proteins for TSPAN5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000307701 for TSPAN5 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045747 positive regulation of Notch signaling pathway IMP 23091066
GO:0051604 protein maturation IMP 23091066
GO:0090002 establishment of protein localization to plasma membrane IMP 23091066
genes like me logo Genes that share ontologies with TSPAN5: view

No data available for Pathways by source for TSPAN5 Gene

Transcripts for TSPAN5 Gene

Unigene Clusters for TSPAN5 Gene

Tetraspanin 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for TSPAN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN5 Gene

mRNA expression in normal human tissues for TSPAN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TSPAN5 Gene

SOURCE GeneReport for Unigene cluster for TSPAN5 Gene Hs.118118

genes like me logo Genes that share expressions with TSPAN5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN5 Gene

Orthologs for TSPAN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN5 35
  • 99.88 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia TSPAN5 35
  • 94.53 (n)
  • 99.63 (a)
  • 100 (a)
(Canis familiaris)
Mammalia TSPAN5 35
  • 95.65 (n)
  • 99.63 (a)
  • 100 (a)
(Mus musculus)
Mammalia Tspan5 35
  • 93.16 (n)
  • 100 (a)
Tspan5 16
Tspan5 36
  • 100 (a)
(Monodelphis domestica)
Mammalia TSPAN5 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN5 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Tspan5 35
  • 92.66 (n)
  • 100 (a)
(Gallus gallus)
Aves TSPAN5 35
  • 88.93 (n)
  • 98.76 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia TSPAN5 36
  • 99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21892 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan5 35
  • 82.96 (n)
  • 95.9 (a)
(Danio rerio)
Actinopterygii tspan5a 35
  • 79.15 (n)
  • 91.39 (a)
tspan5a 36
  • 86 (a)
tspan5b 36
  • 85 (a)
tspan5b 36
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea tsp-12 35
  • 50.84 (n)
  • 47.1 (a)
tsp-12 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for TSPAN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN5 Gene

Gene Tree for TSPAN5 (if available)
Gene Tree for TSPAN5 (if available)

Paralogs for TSPAN5 Gene

genes like me logo Genes that share paralogs with TSPAN5: view

Variants for TSPAN5 Gene

Sequence variations from dbSNP and Humsavar for TSPAN5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3941 -- 98,627,031(+) GAAGC(A/G)TTGTA intron-variant
rs11145 -- 98,471,963(+) TACCA(C/T)CACAA utr-variant-3-prime, nc-transcript-variant
rs15746 -- 98,472,183(-) CTTCC(A/G)TAATT utr-variant-3-prime, nc-transcript-variant
rs846002 -- 98,541,352(+) TATAC(A/C)CTACA intron-variant
rs846003 -- 98,526,315(-) CCTGG(A/C)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN5 Gene

Variant ID Type Subtype PubMed ID
nsv879651 CNV Gain 21882294
esv269762 CNV Insertion 20981092

Relevant External Links for TSPAN5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN5 Gene

Disorders for TSPAN5 Gene

(1) University of Copenhagen DISEASES for TSPAN5 Gene

Relevant External Links for TSPAN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TSPAN5: view

No data available for UniProtKB/Swiss-Prot for TSPAN5 Gene

Publications for TSPAN5 Gene

  1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TSPAN5 Gene

Sources for TSPAN5 Gene

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