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Aliases for TSPAN5 Gene

Aliases for TSPAN5 Gene

  • Tetraspanin 5 2 3 5
  • Transmembrane 4 Superfamily Member 9 2 3 4
  • Tetraspan NET-4 3 4
  • TSPAN-5 3 4
  • TM4SF9 3 4
  • Transmembrane 4 Superfamily, Member 8 3
  • Tetraspan TM4SF 3
  • Tetraspanin-5 3
  • NET-4 3
  • NET4 3

External Ids for TSPAN5 Gene

Previous HGNC Symbols for TSPAN5 Gene

  • TM4SF9

Previous GeneCards Identifiers for TSPAN5 Gene

  • GC04M099751
  • GC04M099612
  • GC04M099391
  • GC04M095128

Summaries for TSPAN5 Gene

Entrez Gene Summary for TSPAN5 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN5 Gene

TSPAN5 (Tetraspanin 5) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN17.

UniProtKB/Swiss-Prot for TSPAN5 Gene

  • Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN5 Gene

Genomics for TSPAN5 Gene

Regulatory Elements for TSPAN5 Gene

Enhancers for TSPAN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G098624 1.1 Ensembl ENCODE dbSUPER 22.4 +31.8 31762 4.3 CTCF JUN RAD21 FOSL1 JUND GATA2 FOS HNF4A TCF7L2 ENSG00000260641 TSPAN5 ENSG00000251523 GC04P098586
GH04G098617 0.6 dbSUPER 37.1 +39.3 39325 4.5 PKNOX1 ESRRA ARNT FEZF1 ZIC2 OSR2 SMARCA4 POLR2A ZNF341 TRIM28 TSPAN5 ENSG00000260641 ENSG00000251523 GC04P098586
GH04G098613 0.9 ENCODE dbSUPER 22.2 +44.0 44033 1.6 PKNOX1 ZNF362 FEZF1 ZNF398 PRDM6 ZNF692 ZBTB48 POLR2A SMARCA4 PRDM10 TSPAN5 ENSG00000251523 GC04P098586
GH04G098612 0.7 ENCODE dbSUPER 22.3 +45.8 45752 0.4 ZNF146 IKZF1 TSPAN5 ENSG00000251523 GC04P098586
GH04G098467 1.4 Ensembl ENCODE dbSUPER 10.4 +190.1 190147 2.7 FOXA2 CBX3 TBL1XR1 SIN3A ZSCAN9 RAD21 ZNF766 EGR1 ZNF143 CREM RAP1GDS1 ENSG00000251523 TSPAN5 ENSG00000214559 GC04P098410
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN5 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000171011 461 2401 FEZF1 BMI1 RAD21 GLIS2 GATA2 ZNF366 EGR2 ZNF263 SP3 ZEB2

Genomic Location for TSPAN5 Gene

98,470,367 bp from pter
98,658,661 bp from pter
188,295 bases
Minus strand

Genomic View for TSPAN5 Gene

Genes around TSPAN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN5 Gene

Proteins for TSPAN5 Gene

  • Protein details for TSPAN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RDY2
    • O60628
    • O60746
    • Q6FHE5
    • Q9JLY1

    Protein attributes for TSPAN5 Gene

    268 amino acids
    Molecular mass:
    30337 Da
    Quaternary structure:
    • Interacts with ADAM10.

neXtProt entry for TSPAN5 Gene

Post-translational modifications for TSPAN5 Gene

  • Glycosylation at Asn49, Asn169, Asn174, and posLast=232232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSPAN5 Gene

Domains & Families for TSPAN5 Gene

Gene Families for TSPAN5 Gene

Suggested Antigen Peptide Sequences for TSPAN5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN5: view

Function for TSPAN5 Gene

Molecular function for TSPAN5 Gene

UniProtKB/Swiss-Prot Function:
Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.

Gene Ontology (GO) - Molecular Function for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN5

CRISPR Products

miRNA for TSPAN5 Gene

miRTarBase miRNAs that target TSPAN5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN5 Gene

Localization for TSPAN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN5: view

Pathways & Interactions for TSPAN5 Gene

SuperPathways for TSPAN5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045747 positive regulation of Notch signaling pathway IMP 23091066
GO:0051604 protein maturation IMP 23091066
GO:0090002 establishment of protein localization to plasma membrane IMP 23091066
genes like me logo Genes that share ontologies with TSPAN5: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN5 Gene

Drugs & Compounds for TSPAN5 Gene

(2) Drugs for TSPAN5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 512
Escitalopram Approved, Investigational Pharma 0
genes like me logo Genes that share compounds with TSPAN5: view

Transcripts for TSPAN5 Gene

Unigene Clusters for TSPAN5 Gene

Tetraspanin 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for TSPAN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for TSPAN5 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN5 Gene

Protein tissue co-expression partners for TSPAN5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN5 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN5 Gene:


Evidence on tissue expression from TISSUES for TSPAN5 Gene

  • Skin(4.7)
  • Nervous system(4.3)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with TSPAN5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN5 Gene

Orthologs for TSPAN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia TSPAN5 35
  • 100 (a)
(Pan troglodytes)
Mammalia TSPAN5 34 35
  • 99.88 (n)
(Canis familiaris)
Mammalia TSPAN5 34 35
  • 95.65 (n)
(Bos Taurus)
Mammalia TSPAN5 34 35
  • 94.53 (n)
(Mus musculus)
Mammalia Tspan5 34 16 35
  • 93.16 (n)
(Rattus norvegicus)
Mammalia Tspan5 34
  • 92.66 (n)
(Ornithorhynchus anatinus)
Mammalia TSPAN5 35
  • 82 (a)
(Gallus gallus)
Aves TSPAN5 34 35
  • 88.93 (n)
(Anolis carolinensis)
Reptilia TSPAN5 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan5 34
  • 82.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21892 34
(Danio rerio)
Actinopterygii tspan5b 35 35
  • 85 (a)
tspan5a 34 35
  • 79.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 35
  • 37 (a)
(Caenorhabditis elegans)
Secernentea tsp-12 34 35
  • 50.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for TSPAN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN5 Gene

Gene Tree for TSPAN5 (if available)
Gene Tree for TSPAN5 (if available)

Paralogs for TSPAN5 Gene

Variants for TSPAN5 Gene

Sequence variations from dbSNP and Humsavar for TSPAN5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs193921080 Uncertain significance 98,486,749(-) CTTTC(A/C)TTCTC intron-variant, nc-transcript-variant, reference, missense
rs1000000966 -- 98,627,369(+) ATTTT(A/C)GTATT intron-variant
rs1000007692 -- 98,579,287(+) TCTTC(A/G)TCACA intron-variant
rs1000026033 -- 98,605,605(+) ATAAG(A/T)CTAAT intron-variant
rs1000028380 -- 98,489,911(+) ACCCC(C/T)GGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN5 Gene

Variant ID Type Subtype PubMed ID
dgv1516e212 CNV loss 25503493
esv2760882 CNV gain 21179565
esv2763801 CNV gain 21179565
esv3305485 CNV mobile element insertion 20981092
esv3339311 CNV insertion 20981092
esv3601538 CNV loss 21293372
esv3601539 CNV loss 21293372
esv3601540 CNV loss 21293372
esv3601541 CNV loss 21293372
esv3893996 CNV loss 25118596
nsv1004181 CNV gain 25217958
nsv474755 CNV novel sequence insertion 20440878
nsv594940 CNV gain 21841781

Variation tolerance for TSPAN5 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN5 Gene

Disorders for TSPAN5 Gene

Relevant External Links for TSPAN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN5 Gene

Publications for TSPAN5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 3 4 64
  5. TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. (PMID: 26686862) Jouannet S. … Rubinstein E. (Cell. Mol. Life Sci. 2016) 4 64

Products for TSPAN5 Gene

Sources for TSPAN5 Gene

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