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TSPAN4 Gene

protein-coding   GIFtS: 53
GCID: GC11P000843

Tetraspanin 4

(Previous name: transmembrane 4 superfamily member 7)
(Previous symbol: TM4SF7)
  See TSPAN4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tetraspanin 41 2     TETRASPAN2
TM4SF71 2 3 5     TSPAN-42
Transmembrane 4 Superfamily Member 71 2 3     Tetraspan TM4SF2
NAG22 3 5     tetraspanin-42
Novel Antigen 22 3     Tspan-43
NAG-22 3     

External Ids:    HGNC: 118591   Entrez Gene: 71062   Ensembl: ENSG000002140637   OMIM: 6026445   UniProtKB: O148173   
ORGUL members:         

Export aliases for TSPAN4 gene to outside databases

Previous GC identifers: GC00U921553 GC11P000833 GC11P000658


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPAN4 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar
in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4
superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TSPAN4 Gene:
TSPAN4 (tetraspanin 4) is a protein-coding gene. Diseases associated with TSPAN4 include congenital hypomyelination neuropathy. An important paralog of this gene is TSPAN2.

Gene Wiki entry for TSPAN4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN4 gene promoter:
         POU2F1   AP-4   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSPAN4 promoter sequence
   Search Chromatin IP Primers for TSPAN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

TSPAN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000843:  view genomic region     (about GC identifiers)

Start:
842,808 bp from pter      End:
867,116 bp from pter
Size:
24,309 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSN4_HUMAN, O14817 (See protein sequence)
Recommended Name: Tetraspanin-4  
Size: 238 amino acids; 26118 Da
Subunit: Forms a complex with integrins
Secondary accessions: Q6IAP6

Explore the universe of human proteins at neXtProt for TSPAN4: NX_O14817

Explore proteomics data for TSPAN4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn152, Asn161

  • See TSPAN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001020405.1  NP_001020406.1  NP_001020407.1  NP_001020408.1  NP_001020409.1  NP_001020410.1  NP_003262.1  

    ENSEMBL proteins: 
     ENSP00000380552   ENSP00000380558   ENSP00000437266   ENSP00000433980   ENSP00000386513  
     ENSP00000431943   ENSP00000434818   ENSP00000324304   ENSP00000386899   ENSP00000436260  
     ENSP00000380555   ENSP00000380554   ENSP00000380553   ENSP00000380551  

    TSPAN4 Human Recombinant Protein Products:

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    Novus Biologicals TSPAN4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSPAN4

     
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    Search antibodies-online for proteins for TSPAN4 

     
    antibodies-online peptides for TSPAN4

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    antibodies-online antibodies for TSPAN4 (20 products) 

    TSPAN4 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry O14817

    ProtoNet protein and cluster: O14817

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN4_HUMAN, O14817
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with TSPAN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TSPAN4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TSPAN4:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPAN4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSPAN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPAN4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPAN4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSPAN4:
    hsa-mir-1 (MIRT004983)

    Block miRNA regulation of human, mouse, rat TSPAN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN4 (see all 10):
    hsa-miR-3673 hsa-miR-206 hsa-miR-29c hsa-miR-29a hsa-miR-1271 hsa-miR-1 hsa-miR-182 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSPAN4
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TSPAN4 (see all 38)
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    GenScript: all cDNA clones in your preferred vector (see all 7): TSPAN4 (NM_001025239)
    Sino Biological Human cDNA Clone for TSPAN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN4

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TSPAN4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN4_HUMAN, O14817: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9360996
    GO:0005887integral component of plasma membrane TAS9360996
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TSPAN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN4
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TSPAN4 (O148173 ENSP000003243044) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD46P155293, ENSP000003138754I2D: score=2 STRING: ENSP00000313875
    ITGA3P260063, ENSP000000077224I2D: score=3 STRING: ENSP00000007722
    ITGB1P055563, ENSP000003640944I2D: score=2 STRING: ENSP00000364094
    CD81P600333, ENSP000002636454I2D: score=3 STRING: ENSP00000263645
    CD9P219263, ENSP000000091804I2D: score=3 STRING: ENSP00000009180
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9360996

    Find genes that share ontologies with TSPAN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN4 (TSN4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPAN4 gene (7 alternative transcripts): 
    NM_001025234.1  NM_001025235.1  NM_001025236.1  NM_001025237.1  NM_001025238.1  NM_001025239.1  NM_003271.4  

    Unigene Cluster for TSPAN4:

    Tetraspanin 4
    Hs.654836  [show with all ESTs]
    Unigene Representative Sequence: AK126635
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000397397(uc001lsd.1 uc001lsf.1) ENST00000397411 ENST00000530404
    ENST00000525334 ENST00000409543 ENST00000525201 ENST00000526055 ENST00000524895
    ENST00000532375 ENST00000346501 ENST00000464987 ENST00000409531 ENST00000527644
    ENST00000468468 ENST00000529566 ENST00000494815 ENST00000397408(uc001lsg.1 uc001lsh.1)
    ENST00000397406(uc001lsi.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSPAN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN4 (see all 10):
    hsa-miR-3673 hsa-miR-206 hsa-miR-29c hsa-miR-29a hsa-miR-1271 hsa-miR-1 hsa-miR-182 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSPAN4
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN4
    Clone
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    OriGene ORF clones in mouse, rat for TSPAN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): TSPAN4 (NM_001025239)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN4
    Primer
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    OriGene qPCR primer pairs and template standards for TSPAN4
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN4
      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN4
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN4

    Additional mRNA sequence: 

    AF022813.1 AF054841.1 AK126456.1 AK126635.1 AK291089.1 BC000389.2 BC019314.2 BC093031.1 
    BT006776.1 CR457108.1 

    Selected DOTS entries (see all 31):

    DT.100880780  DT.120756507  DT.315438  DT.100800781  DT.101957538  DT.95347260  DT.95347272  DT.120756528 
    DT.100880783  DT.97860290  DT.120756392  DT.92437343  DT.95347255  DT.95347259  DT.95347261  DT.100685257 
    DT.101985293  DT.120756451  DT.92437344  DT.95347257  DT.100880776  DT.100880785  DT.100880786  DT.120756442 

    Selected AceView cDNA sequences (see all 370):

    AW275913 AI826977 BP372658 CF529116 BM551494 NM_003271 AI561029 AI686432 
    AI183714 AI559349 BU543865 BU625643 AW250833 BF568399 BM755435 BU623781 
    BM471024 BU624599 BC000389 BC019314 BU626186 BQ019186 BQ958386 AI131198 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGAGGAG
    TSPAN4 Expression
    About this image


    TSPAN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    TSPAN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654836

    UniProtKB/Swiss-Prot: TSN4_HUMAN, O14817
    Tissue specificity: Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan41 , 5 tetraspanin 41, 5 87.25(n)1
    93.7(a)1
      7 (86.83 cM)5
    645401  NM_001252588.11  NP_001239517.11 
     1414752405 
    chicken
    (Gallus gallus)
    Aves TSPAN41 tetraspanin 4 78.43(n)
    86.55(a)
      423104  XM_421038.4  XP_421038.3 
    lizard
    (Anolis carolinensis)
    Reptilia TSPAN46
    tetraspanin 4
    74(a)
    1 ↔ 1
    1(72743452-73299677)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.236702 Xenopus laevis transcribed sequence with weak similarity more 71.47(n)    BJ065840.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tspan4a1 tetraspanin 4a 73.95(n)
    71.43(a)
      436620  NM_001002348.1  NP_001002348.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp5D6
    Tetraspanin 5D
    26(a)
    1 → many
    X(5963164-5968890)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-86
    Protein TSP-8 (tsp-8) mRNA, complete cds
    26(a)
    1 → many
    X(14726626-14729482) WBGene00006634


    ENSEMBL Gene Tree for TSPAN4 (if available)
    TreeFam Gene Tree for TSPAN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN4 gene
    TSPAN22  CD92  TSPAN12  CD372  TSPAN92  CD532  CD822  TSPAN182  
    CD812  TSPAN82  
    Selected SIMAP similar genes for TSPAN4 using alignment to 8 protein entries:     TSN4_HUMAN (see all proteins) (see all similar genes):
    TSPAN9    CD53    BTCC-1    CD82    TSPAN18    TSPAN5
    CD151    CD9    CD63    TSPAN8    CD37    TSPAN16
    TSPAN11    TSPAN1    TSPAN2    CD81    TSPAN14    TSPAN3

    Find genes that share paralogs with TSPAN4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN4 (see all 613)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0366164
    A breast cancer sample4--see VAR_0366162 I M mis40--------
    rs350441191,2
    C,F--657306(+) TCCAGG/ACTGGT 1 -- us2k14Minor allele frequency- A:0.03NS NA 58
    rs1156056181,2
    F--657707(+) CCCAGC/TCCCGG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1862843901,2
    C--657725(+) CCCACA/GGCGGA 1 -- us2k10--------
    rs350976721,2
    C,F--657746(+) AGCCCC/TGGCCC 1 -- us2k13Minor allele frequency- T:0.02NS NA 94
    rs2019651041,2
    --657751(+) CGGCCC/TGCGCC 1 -- us2k10--------
    rs1124161061,2
    C--657758(+) CGCCTC/G/TACCCC 1 -- us2k11CSA 1
    rs1113296351,2
    C--657759(+) GCCTCA/C/TCCCCT 1 -- us2k11CSA 1
    rs3680293981,2
    C--844707(+) TTCTG-/G/GG  
            
    GGGGG
    7 -- int10--------
    rs1847349831,2
    C--844715(+) GGGGGG/TGGTCT 7 -- int10--------

    HapMap Linkage Disequilibrium report for TSPAN4 (842808 - 867116 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TSPAN4 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    esv2743876CNV Deletion23290073
    esv2743878CNV Deletion23290073
    esv2743877CNV Deletion23290073
    esv2669189CNV Deletion23128226
    esv2743874CNV Deletion23290073
    nsv832044CNV Loss17160897
    nsv469923CNV Loss18288195
    esv29561CNV Loss19812545
    dgv946n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602644    OMIM disorders: --

    1 disease for TSPAN4:    
    About MalaCards
    congenital hypomyelination neuropathy


    Find genes that share disorders with TSPAN4           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: TSPAN4 (1 document)

    Export disorders for TSPAN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN4 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with TSPAN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. (PubMed id 9360996)1, 2, 3, 9 Tachibana I.... Hemler M.E. (J. Biol. Chem. 1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PubMed id 9714763)1, 2 Todd S.C.... Levy S. (Biochim. Biophys. Acta 1998)
    5. Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth. (PubMed id 22236579)1 Li Y....Zhao M. (Acta Biochim. Biophys. Sin. (Shanghai) 2012)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    8. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7106 HGNC: 11859 AceView: TM4SF7 Ensembl:ENSG00000214063 euGenes: HUgn7106
    ECgene: TSPAN4 H-InvDB: TSPAN4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TSPAN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TSPAN4 gene:
    Search GeneIP for patents involving TSPAN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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