Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPAN4 Gene

protein-coding   GIFtS: 50
GCID: GC11P000843

tetraspanin 4

(Previous name: transmembrane 4 superfamily member 7 )
(Previous symbol: TM4SF7)
 Explore 14 diseases affiliated with
TSPAN4 via our new
 Human Malady Compendium 
Biological research products
for TSPAN4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tetraspanin 41 2     TSPAN-41 2
TM4SF71 2 3 5     Novel Antigen 22 3
Transmembrane 4 Superfamily Member 71 2 3     Tetraspan TM4SF2
NAG-21 2 3     Tetraspanin-41
NAG22 3 5     Tspan-43
TETRASPAN1 2     

External Ids:    HGNC: 118591   Entrez Gene: 71062   Ensembl: ENSG000002140637   OMIM: 6026445   UniProtKB: O148173   

Export aliases for TSPAN4 gene to outside databases

Previous GC identifers: GC00U921553 GC11P000833 GC11P000658


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSPAN4:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.
The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,
growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family
member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul
2008)

Gene Wiki entry for TSPAN4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPAN4 gene promoter:
         POU2F1   AP-4   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSPAN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPAN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

TSPAN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000843:  view genomic region     (about GC identifiers)

Start:
842,808 bp from pter      End:
867,116 bp from pter
Size:
24,309 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSN4_HUMAN, O14817 (See protein sequence)
Recommended Name: Tetraspanin-4  
Size: 238 amino acids; 26118 Da
Subunit: Forms a complex with integrins
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q6IAP6

Explore the universe of human proteins at neXtProt for TSPAN4: NX_O14817

TSPAN4 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (7 alternative transcripts): 
NP_001020405.1  NP_001020406.1  NP_001020407.1  NP_001020408.1  NP_001020409.1  NP_001020410.1  NP_003262.1  

ENSEMBL proteins: 
 ENSP00000380552   ENSP00000380558   ENSP00000437266   ENSP00000433980   ENSP00000386513  
 ENSP00000431943   ENSP00000434818   ENSP00000324304   ENSP00000386899   ENSP00000436260  
 ENSP00000380555   ENSP00000380554   ENSP00000380553   ENSP00000380551  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate (see all 9): TSPAN4
OriGene Custom Protein Services for TSPAN4 
GenScript Custom Purified and Recombinant Proteins Services for TSPAN4
Novus Biologicals TSPAN4 Lysates
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for TSPAN4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS9360996
GO:0005887integral to plasma membrane TAS9360996
GO:0016021integral to membrane ----


TSPAN4 for ontologies           About GeneDecksing



TSPAN4 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for TSPAN4 
GenScript Custom Superior Antibodies Services for TSPAN4
Novus Biologicals TSPAN4 Antibodies
Search for Antibodies for TSPAN4 at Abcam  
Uscn Antibodies for TSPAN4
ThermoFisher Antibodies for TSPAN4

Assay Products for TSPAN4: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TSPAN4
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for TSPAN4


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TSPAN4 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR018499 Tetraspanin/Peripherin
 IPR018503 Tetraspanin_CS
 IPR000301 Tetraspanin
 IPR008952 Tetraspanin_EC2

Graphical View of Domain Structure for InterPro Entry O14817

ProtoNet protein and cluster: O14817

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: TSN4_HUMAN, O14817
Similarity: Belongs to the tetraspanin (TM4SF) family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
Products:
    
miRTarBase miRNAs that target TSPAN4:
hsa-mir-1 (MIRT004983)

OriGene 3'-UTR Clone (see all 7): TSPAN4
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN4
8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN4 (see all 10):
hsa-miR-3673 hsa-miR-206 hsa-miR-29c hsa-miR-29a hsa-miR-1271 hsa-miR-1 hsa-miR-182 hsa-miR-613
SwitchGear 3'UTR luciferase reporter plasmidTSPAN4 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN4 (see all 7)
OriGene shRNA RFP: TSPAN4
OriGene siRNA: TSPAN4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TSPAN4

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN4 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN4 (see all 8)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 7): TSPAN4 (NM_001025239)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN4 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for TSPAN4
Search LifeMap BioReagents cell lines for TSPAN4

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----


TSPAN4 for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for TSPAN4:
 Decreased POU5F1-GFP protein e 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN4

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for TSPAN4 (O148173 ENSP000003243044) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
CD46P155293, ENSP000003138754I2D: score=2 STRING: ENSP00000313875
ITGA3P260063, ENSP000000077224I2D: score=3 STRING: ENSP00000007722
ITGB1P055563, ENSP000003640944I2D: score=2 STRING: ENSP00000364094
CD81P600333, ENSP000002636454I2D: score=3 STRING: ENSP00000263645
CD9P219263, ENSP000000091804I2D: score=3 STRING: ENSP00000009180
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006461protein complex assembly TAS9360996


TSPAN4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSPAN4
Search CenterWatch for drugs/clinical trials and news about TSPAN4 / TSN4 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPAN4 gene (7 alternative transcripts): 
NM_001025234.1  NM_001025235.1  NM_001025236.1  NM_001025237.1  NM_001025238.1  NM_001025239.1  NM_003271.4  

Unigene Cluster for TSPAN4:

Tetraspanin 4
Hs.654836  [show with all ESTs]
Unigene Representative Sequence: AK126635
18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
ENST00000397397(uc001lsd.1 uc001lsf.1) ENST00000397411 ENST00000530404
ENST00000525334 ENST00000409543 ENST00000525201 ENST00000526055 ENST00000524895
ENST00000532375 ENST00000346501 ENST00000464987 ENST00000409531 ENST00000527644
ENST00000468468 ENST00000529566 ENST00000494815 ENST00000397408(uc001lsg.1 uc001lsh.1)
ENST00000397406(uc001lsi.1)

miRNA
Products:
     
OriGene 3'-UTR Clone (see all 7): TSPAN4
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN4
8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN4 (see all 10):
hsa-miR-3673 hsa-miR-206 hsa-miR-29c hsa-miR-29a hsa-miR-1271 hsa-miR-1 hsa-miR-182 hsa-miR-613
SwitchGear 3'UTR luciferase reporter plasmidTSPAN4 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN4 (see all 7)
OriGene shRNA RFP: TSPAN4
OriGene siRNA: TSPAN4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN4
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN4 (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN4 (see all 8)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 7): TSPAN4 (NM_001025239)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN4 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN4
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN4

Additional cDNA sequence: 

AF022813.1 AF054841.1 AK126456.1 AK126635.1 AK291089.1 BC000389.2 BC019314.2 BC093031.1 
BT006776.1 CR457108.1 

24/31 DOTS entries (see all 31):

DT.100880780  DT.120756507  DT.315438  DT.100800781  DT.101957538  DT.95347260  DT.95347272  DT.97860290 
DT.120756528  DT.100880783  DT.120756392  DT.92437343  DT.95347255  DT.95347259  DT.95347261  DT.100685257 
DT.101985293  DT.120756451  DT.92437344  DT.95347257  DT.100880776  DT.100880785  DT.100880786  DT.120756442 

24/370 AceView cDNA sequences (see all 370):

BC019314 BU624599 BU543865 BQ019186 BU626186 CF529116 AI183714 AI686432 
BQ771887 AI826977 NM_003271 BM551494 BC000389 BM760336 BP372658 AI559349 
AI131198 BM755435 AI561029 AW275913 BU623781 BM694970 AW250833 BQ958386 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPAN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGAGGAG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

TSPAN4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
3 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
KidneyS-shaped BodyKidney
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See TSPAN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPAN4

SOURCE GeneReport for Unigene cluster: Hs.654836

UniProtKB/Swiss-Prot: TSN4_HUMAN, O14817
Tissue specificity: Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets

    SABiosciences Custom PCR Arrays for TSPAN4
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN4
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN4
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN4
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TSPAN4 gene from 6/19 species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves TSPAN41 tetraspanin 4 78.43(n)
86.55(a)
  423104  XM_421038.3  XP_421038.2 
lizard
(Anolis carolinensis)
Reptilia TSPAN46
--
80(a)
1 ↔ 1
1(72743455-73016976)
African clawed frog
(Xenopus laevis)
Amphibia Xl.236702 Xenopus laevis transcribed sequence with weak similarity more 71.47(n)    BJ065840.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:921741 zgc:92174 73.95(n)
71.43(a)
  436620  NM_001002348.1  NP_001002348.1 
fruit fly
(Drosophila melanogaster)
Insecta Tsp3A6
Tsp5D6
(see all 3)
Tetraspanin 5D
(see all 3)
25(a)
24(a)
(see all 3)
possible ortholog
1 ↔ many
(see all 3)
X(2511791-2513771)
X(5963164-5968890)
worm
(Caenorhabditis elegans)
Secernentea tsp-86
tsp-146
TetraSPanin family member (tsp-14)
26(a)
12(a)
possible ortholog
possible ortholog
X(14726556-14729412)
X(4866653-4874627)


ENSEMBL Gene Tree for TSPAN4 (if available)
TreeFam Gene Tree for TSPAN4 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TSPAN4 gene
CD1512  TSPAN12  CD372  TSPAN62  TSPAN92  TSPAN32  CD632  CD532  
CD822  TSPAN182  TSPAN72  TSPAN112  ENSG000002503492  TSPAN82  
18/22 SIMAP similar genes for TSPAN4 using alignment to 8 protein entries:     TSN4_HUMAN (see all proteins) (see all similar genes):
TSPAN9    CD53    BTCC-1    CD82    TSPAN18    TSPAN5
CD151    CD9    CD63    TSPAN8    TSPAN16    TSPAN11
CD37    TSPAN1    TSPAN2    CD81    TSPAN14    TSPAN3

TSPAN4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/459 NCBI SNPs in TSPAN4 are shown (see all 459    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1847349831,2
C,--844715(+) GGGGGG/TGGTCT 7 -- int10--------
rs1996907241,2
--844715(+) GGGGG-/TGGTCT 7 -- int10--------
rs1888685861,2
--844779(+) GCCTCC/TTGTGG 7 -- int10--------
rs284196531,2
C,--844862(+) GCAAAC/GGACCA 7 -- int19Minor allele frequency- G:0.01NA WA CSA 253
rs284915851,2
C,--844969(+) GGGAGT/CACGGG 7 -- int113Minor allele frequency- C:0.02NA WA CSA EA 379
rs1498375251,2
--845059(+) GGTGGC/GATCAG 7 -- int10--------
rs112463301,2
C,F,--845077(+) CCGCCC/GGGAGG 7 -- int15Minor allele frequency- G:0.33NA WA EA 362
rs1446270411,2
--845220(+) CCCCC-/AGGGTG 7 -- int10--------
rs1925935911,2
--845300(+) CAAGGC/TCACTG 7 -- int10--------
rs287476831,2
C,--845311(+) CCCACT/CGTACC 7 -- int112Minor allele frequency- C:0.01NA WA CSA EA 379

HapMap Linkage Disequilibrium report for TSPAN4 (842808 - 867116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TSPAN4
     7 CNVs: 29886 3831 71221 29883 29885 31793 4726

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN4
DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TSPAN4 for disorders           About GeneDecksing

OMIM gene information: 602644    OMIM disorders: --

14 diseases for TSPAN4:    About MalaCards
charcot-marie-tooth disease    charcot-marie-tooth disease type 3    pelizaeus-merzbacher disease    congenital hypomyelination neuropathy
tooth disease    squamous cell carcinoma    endometrial adenocarcinoma    neuropathy
hepatitis b    gingivitis    lung cancer    adenocarcinoma
hepatitis    carcinoma

Human Genome Epidemiology (HuGE) Navigator: TSPAN4 (1 document)

Export disorders for TSPAN4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TSPAN4 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with TSPAN4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. (PubMed id 9360996)1, 2, 3, 9 Tachibana I.... Hemler M.E. (1997)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PubMed id 9714763)1, 2 Todd S.C.... Levy S. (1998)
  5. Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatoce llular carcinoma and accelerates tumor cell growth. (PubMed id 22236579)1 Li Y....Zhao M. (2012)
  6. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
  7. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
  8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
  9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
  10. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. (PubMed id 14671302)1 Clark A.G....Cargill M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7106 HGNC: 11859 AceView: TM4SF7 Ensembl:ENSG00000214063 euGenes: HUgn7106
ECgene: TSPAN4 H-InvDB: TSPAN4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TSPAN4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TSPAN4 gene:
Search GeneIP for patents involving TSPAN4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
 Browse OriGene Antibodies   OriGene shRNA RFP for TSPAN4  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN4  
 OriGene Protein Over-expression Lysate for TSPAN4   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for TSPAN4   OriGene 3'-UTR Clone for TSPAN4  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN4  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for TSPAN4   OriGene Custom Protein Services for TSPAN4  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN4
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN4
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN4
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN4
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN4
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN4
 GenScript Custom Purified and Recombinant Proteins Services for TSPAN4 GenScript cDNA clones with any tag delivered in your preferred vector for TSPAN4
 GenScript Custom Assay Services for TSPAN4 GenScript Custom Superior Antibodies Services for TSPAN4
 GenScript Custom overexpressing Cell Line Services for TSPAN4 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in TSPAN4 promoter
 Search Chromatin IP Primers for TSPAN4
 RT2 qPCR Primer Assay in human, mouse, rat TSPAN4
 Search GNC Networks for TSPAN4
 SABiosciences Custom PCR Arrays for TSPAN4
 Search Tocris compounds for TSPAN4
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 TSPAN4 antibodies
 TSPAN4 lysates
 Search for Antibodies for TSPAN4 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for TSPAN4
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 TSPAN4 Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for TSPAN4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN4
 SwitchGear 3'UTR luciferase reporter plasmids for TSPAN4
 SwitchGear Promoter luciferase reporter plasmids for TSPAN4
 ThermoFisher Antibodies for TSPAN4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN4
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      TSPAN4 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4