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Aliases for TSPAN4 Gene

Aliases for TSPAN4 Gene

  • Tetraspanin 4 2 3
  • Transmembrane 4 Superfamily Member 7 2 3 4
  • Novel Antigen 2 3 4
  • TSPAN-4 3 4
  • TM4SF7 3 4
  • NAG-2 3 4
  • NAG2 3 4
  • Tetraspan TM4SF 3
  • Tetraspan 3

External Ids for TSPAN4 Gene

Previous HGNC Symbols for TSPAN4 Gene

  • TM4SF7

Previous GeneCards Identifiers for TSPAN4 Gene

  • GC00U921553
  • GC11P000833
  • GC11P000658

Summaries for TSPAN4 Gene

Entrez Gene Summary for TSPAN4 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN4 Gene

TSPAN4 (Tetraspanin 4) is a Protein Coding gene. Diseases associated with TSPAN4 include congenital hypomyelination neuropathy. GO annotations related to this gene include integrin binding and antigen binding. An important paralog of this gene is TSPAN9.

Gene Wiki entry for TSPAN4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN4 Gene

Genomics for TSPAN4 Gene

Regulatory Elements for TSPAN4 Gene

Transcription factor binding sites by QIAGEN in the TSPAN4 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSPAN4 Gene

842,808 bp from pter
867,116 bp from pter
24,309 bases
Plus strand

Genomic View for TSPAN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN4 Gene

Proteins for TSPAN4 Gene

  • Protein details for TSPAN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6IAP6

    Protein attributes for TSPAN4 Gene

    238 amino acids
    Molecular mass:
    26118 Da
    Quaternary structure:
    • Forms a complex with integrins

neXtProt entry for TSPAN4 Gene

Proteomics data for TSPAN4 Gene at MOPED

Post-translational modifications for TSPAN4 Gene

  • Glycosylation at Asn 152 and Asn 161

No data available for DME Specific Peptides for TSPAN4 Gene

Domains & Families for TSPAN4 Gene

Gene Families for TSPAN4 Gene

Suggested Antigen Peptide Sequences for TSPAN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN4: view

Function for TSPAN4 Gene

Gene Ontology (GO) - Molecular Function for TSPAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IDA 9360996
GO:0005178 integrin binding IPI 9360996
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TSPAN4: view

Phenotypes for TSPAN4 Gene

GenomeRNAi human phenotypes for TSPAN4:
genes like me logo Genes that share phenotypes with TSPAN4: view

Animal Model Products

CRISPR Products

miRNA for TSPAN4 Gene

miRTarBase miRNAs that target TSPAN4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN4 Gene

Localization for TSPAN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN4 Gene COMPARTMENTS Subcellular localization image for TSPAN4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
endosome 1
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TSPAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 9360996
GO:0005887 integral component of plasma membrane IBA --
GO:0005925 focal adhesion IDA 21423176
GO:0016021 integral component of membrane --
GO:0031982 vesicle IDA 9360996
genes like me logo Genes that share ontologies with TSPAN4: view

Pathways & Interactions for TSPAN4 Gene

SuperPathways for TSPAN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IDA 9360996
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN4: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN4 Gene

Drugs & Compounds for TSPAN4 Gene

No Compound Related Data Available

Transcripts for TSPAN4 Gene

Unigene Clusters for TSPAN4 Gene

Tetraspanin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN4 Gene

No ASD Table

Relevant External Links for TSPAN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN4 Gene

mRNA expression in normal human tissues for TSPAN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPAN4 Gene

This gene is overexpressed in Prostate (15.3), Lung (12.5), and Spleen (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN4 Gene

SOURCE GeneReport for Unigene cluster for TSPAN4 Gene Hs.654836

mRNA Expression by UniProt/SwissProt for TSPAN4 Gene

Tissue specificity: Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets
genes like me logo Genes that share expression patterns with TSPAN4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TSPAN4 Gene

Orthologs for TSPAN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN4 35
  • 90.2 (n)
  • 93.28 (a)
  • 93 (a)
(Canis familiaris)
Mammalia TSPAN4 35
  • 86.97 (n)
  • 93.1 (a)
  • 56 (a)
(Mus musculus)
Mammalia Tspan4 35
  • 87.25 (n)
  • 93.7 (a)
Tspan4 16
Tspan4 36
  • 94 (a)
(Pan troglodytes)
Mammalia TSPAN4 35
  • 99.58 (n)
  • 99.58 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan4 35
  • 86.69 (n)
  • 93.28 (a)
(Monodelphis domestica)
Mammalia TSPAN4 36
  • 87 (a)
(Gallus gallus)
Aves TSPAN4 35
  • 78.43 (n)
  • 86.55 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia TSPAN4 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492951 35
  • 76.33 (n)
  • 82.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23670 35
(Danio rerio)
Actinopterygii tspan4a 35
  • 73.95 (n)
  • 71.43 (a)
tspan4a 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9843 35
fruit fly
(Drosophila melanogaster)
Insecta Tsp5D 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea tsp-8 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for TSPAN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN4 Gene

Gene Tree for TSPAN4 (if available)
Gene Tree for TSPAN4 (if available)

Paralogs for TSPAN4 Gene

Paralogs for TSPAN4 Gene

genes like me logo Genes that share paralogs with TSPAN4: view

Variants for TSPAN4 Gene

Sequence variations from dbSNP and Humsavar for TSPAN4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7091 -- 866,794(+) GCCCT(A/G)GCTCA utr-variant-3-prime
rs182795105 -- 860,107(+) CCTCC(A/G)GACAG intron-variant
rs182553517 -- 866,818(+) CCTCC(A/G)GACCC utr-variant-3-prime
rs182531296 -- 849,507(+) CCGTG(A/G)GGGGA intron-variant
rs182526570 -- 865,673(+) CAGCC(C/T)GACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN4 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
dgv946n71 CNV Loss 21882294
essv11734 CNV CNV 17122850
dgv947n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294
nsv832044 CNV Loss 17160897
nsv896608 CNV Loss 21882294
dgv954n71 CNV Gain 21882294
nsv896619 CNV Gain 21882294
nsv896633 CNV Loss 21882294
dgv956n71 CNV Loss 21882294
nsv8760 CNV Loss 18304495
nsv896636 CNV Loss 21882294
nsv896638 CNV Gain 21882294
esv29561 CNV Loss 19812545
esv2743874 CNV Deletion 23290073
esv2743876 CNV Deletion 23290073
esv2743877 CNV Deletion 23290073
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226

Variation tolerance for TSPAN4 Gene

Residual Variation Intolerance Score: 69.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN4 Gene

Disorders for TSPAN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPAN4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
congenital hypomyelination neuropathy
- elite association

Relevant External Links for TSPAN4

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSPAN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN4 Gene

Publications for TSPAN4 Gene

  1. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. (PMID: 9360996) Tachibana I. … Hemler M.E. (J. Biol. Chem. 1997) 2 23 67
  2. Generation of anti-NAG-2 mAb from patients' memory B cells: implications for a novel therapeutic strategy in systemic sclerosis. (PMID: 20207716) Traggiai E. … Puccetti A. (Int. Immunol. 2010) 23 67
  3. Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. (PMID: 19036703) Choi S. … Lee J.W. (Blood 2009) 23 67
  4. Tetraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma. (PMID: 19330835) Hirano C. … Takagi R. (Int. J. Cancer 2009) 23 67
  5. Expression and function of transmembrane-4 superfamily (tetraspanin) proteins in osteoclasts: reciprocal roles of Tspan-5 and NET-6 during osteoclastogenesis. (PMID: 17965585) Iwai K. … Saeki Y. (Allergol Int 2007) 23 67

Products for TSPAN4 Gene

Sources for TSPAN4 Gene

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