Aliases for TSPAN33 Gene
Aliases for TSPAN33 Gene
External Ids for TSPAN33 Gene
- HGNC: 28743
- Entrez Gene: 340348
- Ensembl: ENSG00000158457
- OMIM: 610120
- UniProtKB: Q86UF1
Previous GeneCards Identifiers for TSPAN33 Gene
- GC07P128379
- GC07P128571
- GC07P128784
- GC07P123145
Summaries for TSPAN33 Gene
GeneCards Summary for TSPAN33 Gene
TSPAN33 (Tetraspanin 33) is a Protein Coding gene. Diseases associated with TSPAN33 include Intracranial Vasospasm and Basilar Artery Occlusion. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN17.
UniProtKB/Swiss-Prot for TSPAN33 Gene
-
Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).
Additional gene information for TSPAN33 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN33 Gene
Genomics for TSPAN33 Gene
GeneHancer (GH) Regulatory Elements for TSPAN33 Gene
- Top Transcription factor binding sites by QIAGEN in the TSPAN33 gene promoter:
Regulatory Element Products
Genomic Locations for TSPAN33 Gene
- chr7:129,144,716-129,169,697
- (GRCh38/hg38)
- Size:
- 24,982 bases
- Orientation:
- Plus strand
- chr7:128,784,712-128,809,534
- (GRCh37/hg19)
Genomic View for TSPAN33 Gene
- Cytogenetic band:
-
- 7q32.1 by Ensembl
- 7q32.1 by Entrez Gene
- 7q32.1 by HGNC


RefSeq DNA sequence for TSPAN33 Gene
Proteins for TSPAN33 Gene
-
Protein details for TSPAN33 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UF1-TSN33_HUMAN
- Recommended name:
- Tetraspanin-33
- Protein Accession:
- Q86UF1
Protein attributes for TSPAN33 Gene
- Size:
- 283 amino acids
- Molecular mass:
- 31538 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (PubMed:17158226). Interacts with ADAM10 (PubMed:26686862).
Protein Expression for TSPAN33 Gene
Post-translational modifications for TSPAN33 Gene
- Glycosylation at isoforms=172
Other Protein References for TSPAN33 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TSPAN33 (TSPAN33)
-
Custom Antibody ServicesOriGene Antibodies for TSPAN33
- Novus Biologicals Antibodies for TSPAN33
-
Abcam antibodies for TSPAN33
- Invitrogen Antibodies for TSPAN33
- GeneTex TSPAN33 antibody for TSPAN33
Protein Products
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- Novus Biologicals proteins for TSPAN33
- antibodies-online: Search results for 4 available TSPAN33 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for TSPAN33
Assay Products
No data available for DME Specific Peptides for TSPAN33 Gene
Domains & Families for TSPAN33 Gene
Gene Families for TSPAN33 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for TSPAN33 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TSPAN33 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86UF1- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for TSPAN33 Gene
Molecular function for TSPAN33 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).
Phenotypes From GWAS Catalog for TSPAN33 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0019899 | enzyme binding | IEA,IPI | 23091066 |
Phenotypes for TSPAN33 Gene
- MGI mutant phenotypes for TSPAN33:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TSPAN33:
Animal Models for TSPAN33 Gene
- MGI Knock Outs for TSPAN33:
-
- Tspan33 tm1Stsa
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TSPAN33
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TSPAN33 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN33 gene
- Search ViGene Biosciences for TSPAN33
CRISPR Products
-
OriGene CRISPR knockouts for TSPAN33
- genomics-online: gRNA clones - Search results for 101 available TSPAN33 gene related products
- Overview of 101 available TSPAN33 gene related products
- Applied Biological Materials CRISPR for TSPAN33
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN33
- GenScript: Design CRISPR guide RNA sequences for TSPAN33
miRNA for TSPAN33 Gene
- miRTarBase miRNAs that target TSPAN33
miRNA Products
- Search ViGene Biosciences for TSPAN33
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TSPAN33
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- Overview of 101 available TSPAN33 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN33 gene
Clone Products
- Sino Biological Human cDNA Clone for TSPAN33
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- VectorBuilder custom plasmid, inducible vectors for TSPAN33
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TSPAN33
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TSPAN33
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TSPAN33
Cell Line Products
-
Horizon Cell Lines for TSPAN33
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN33 Gene
Localization for TSPAN33 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSPAN33 Gene
- Cell membrane; Multi-pass membrane protein.
- Microtubules (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IDA | 23091066 |
GO:0005887 | integral component of plasma membrane | IBA | -- |
GO:0009986 | cell surface | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TSPAN33 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
GO:0051604 | protein maturation | IEA,IDA | 23091066 |
GO:0072659 | protein localization to plasma membrane | IEA,IDA | 23091066 |
No data available for Pathways by source and SIGNOR curated interactions for TSPAN33 Gene
Transcripts for TSPAN33 Gene
mRNA/cDNA for TSPAN33 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (119) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TSPAN33
- genomics-online: gRNA clones - Search results for 101 available TSPAN33 gene related products
- Overview of 101 available TSPAN33 gene related products
- Applied Biological Materials CRISPR for TSPAN33
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN33
- GenScript: Design CRISPR guide RNA sequences for TSPAN33
miRNA Products
- Search ViGene Biosciences for TSPAN33
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TSPAN33
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- genomics-online: shRNA clones - Search results for 101 available TSPAN33 gene related products
- Overview of 101 available TSPAN33 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN33 gene
Clone Products
- Sino Biological Human cDNA Clone for TSPAN33
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TSPAN33
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TSPAN33
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TSPAN33
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TSPAN33
Expression for TSPAN33 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Kidney (Urinary System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for TSPAN33 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN33 Gene
NURSA nuclear receptor signaling pathways regulating expression of TSPAN33 Gene:
TSPAN33SOURCE GeneReport for Unigene cluster for TSPAN33 Gene:
Hs.27267mRNA Expression by UniProt/SwissProt for TSPAN33 Gene:
Q86UF1-TSN33_HUMANEvidence on tissue expression from TISSUES for TSPAN33 Gene
- Intestine(4.3)
- Bone marrow(4.1)
- Nervous system(2.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for TSPAN33
-
OriGene qPCR primer pairs and template standards for TSPAN33
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN33 Gene
Orthologs for TSPAN33 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TSPAN33 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | TSPAN33 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | TSPAN33 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Tspan33 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tspan33 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TSPAN33 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TSPAN33 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | TSPAN33 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tspan33 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | tspan33 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Tsp86D 33 34 |
|
||
Tsp3A 34 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002257 33 |
|
- Species where no ortholog for TSPAN33 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TSPAN33 Gene
Paralogs for TSPAN33 Gene
(15) SIMAP similar genes for TSPAN33 Gene using alignment to 1 proteins:
Variants for TSPAN33 Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000094104 | -- | 129,165,418(+) | T/C | intron_variant | |
rs1000308064 | -- | 129,155,077(+) | A/C | intron_variant | |
rs1000423534 | -- | 129,165,761(+) | T/G | intron_variant | |
rs1000943825 | -- | 129,146,528(+) | C/T | intron_variant | |
rs1001009703 | -- | 129,146,216(+) | T/C | intron_variant |
Additional Variant Information for TSPAN33 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TSPAN33
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN33 Gene
Disorders for TSPAN33 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
intracranial vasospasm |
|
|
basilar artery occlusion |
|
|
subdural empyema |
|
|
heart sarcoma |
|
|
stroke, ischemic |
|
|
Additional Disease Information for TSPAN33
No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN33 Gene
Publications for TSPAN33 Gene
- The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies. (PMID: 16213355) Chen Z … Tsai S (Cancer genetics and cytogenetics 2005) 2 3 4 58
- Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. (PMID: 17158226) Heikens MJ … Tsai S (Blood 2007) 3 4 58
- The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms. (PMID: 16242907) Huang S … Xu A (Genomics 2005) 2 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for TSPAN33 Gene
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- Invitrogen Antibodies for TSPAN33
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- VectorBuilder custom plasmid, inducible vectors for TSPAN33
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TSPAN33
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 56 available TSPAN33 Antibodies ranked by validation data
- Compare Top TSPAN33 Antibodies
- antibodies-online: Search results for available TSPAN33 related products ranked by validation data
- antibodies-online: Search results for 4 available TSPAN33 Proteins ranked by validation data
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- Quality Products:
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- Horizon Cell Lines for TSPAN33
- genomics-online: cdna clones - Search results for 101 available TSPAN33 gene related products
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- Overview of 101 available TSPAN33 gene related products
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- Overview of 101 available TSPAN33 gene related products
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- Overview of 101 available TSPAN33 gene related products
Sources for TSPAN33 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
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- (125) NCBI Bookshelf
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- (132) FANTOM5
- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew