TSPAN33 Gene
protein-coding GIFtS: 46
GCID: GC07P128784
|
|
tetraspanin 33
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Aliases
for TSPAN33 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetraspanin 331 2 | | MGC508441 | | Penumbra1 3 | | Penumbra1 3 | | Proerythroblast New Membrane2 3 | | Tetraspanin-331 | | PEN2 3 | | Tspan-333 | | HPen1 | | Tspan-333 |
Export aliases for TSPAN33 gene to outside databasesPrevious GC identifers: GC07P128379 GC07P128571 GC07P123145 |
Summaries
for TSPAN33 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1Function: Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroidprogenitors (By similarity)
|
Genomic Views
for TSPAN33 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSPAN33 gene promoter:
STAT1 GATA-3 STAT1beta NF-kappaB Arnt GATA-1 GATA-2 STAT1alpha NF-kappaB1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPAN33
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN33 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q32.1 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q32.3TSPAN33 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P128784: view genomic region
(about GC identifiers)
Start:
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128,784,712 bp from pter |
End:
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128,809,534 bp from pter |
Size:
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24,823 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 128,168,549-128,193,491 |
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Proteins
for TSPAN33 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1 (See
protein sequence)Recommended Name: Tetraspanin-33 Size: 283 amino acids; 31538 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for TSPAN33: NX_Q86UF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86UF1
TSPAN33 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848657.1
ENSEMBL proteins: ENSP00000289407
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TSPAN33 for ontologies About GeneDecksing
TSPAN33 Antibody Products:
Assay Products for TSPAN33: |
Protein
Domains /
Families
for TSPAN33 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPAN33 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86UF1ProtoNet protein and cluster: Q86UF1 1 Blocks protein family: IPB000301 Transmembrane four family signature
UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1Similarity: Belongs to the tetraspanin (TM4SF) family |
Function
for TSPAN33 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1Function: Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroidprogenitors (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN33 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN33
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: TSPAN33 (NM_178562) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN33 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN33 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33 |
Animal Models:
Mouse knock-out Tspan33tm1Stsa for TSPAN33
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tspan33):
TSPAN33 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TSPAN33 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN33
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TSPAN33 (ENSP000002894074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TSPAN33 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSPAN33
Search CenterWatch for drugs/clinical trials and news about TSPAN33 / TSN33
|
Transcripts
for TSPAN33 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSPAN33 gene: NM_178562.3 Unigene Cluster for TSPAN33: Tetraspanin 33 Hs.27267 [show with all ESTs]Unigene Representative Sequence: NM_1785623 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000289407(uc003vop.2) ENST00000496963 ENST00000486685(uc003voq.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN33 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN33
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSPAN33 (NM_178562) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN33 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN33 |
Additional cDNA sequence: AF276891.1 AY236849.1 BC044244.1 5 DOTS entries: DT.315426 DT.315427 DT.100814132 DT.95160864 DT.40310326 24/119 AceView cDNA sequences (see all 119): CR609044 AI217778 AW001670 AI078627 BM675347 AA456896 BQ708420 AA631017 AA768759 CA309092 AA232951 BX093063 AW026287 AA715038 AA827439 AA917873 BX280316 BF724098 W95735 BP872796 BQ684452 CA311002 BM714582 AA485019
GeneLoc Exon Structure
|
Expression
for TSPAN33 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPAN33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTTGAATT
About this image
See TSPAN33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPAN33
SOURCE GeneReport for Unigene cluster: Hs.27267
UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1Tissue specificity: Predominantly expressed in erythroblasts
SABiosciences Custom PCR Arrays for TSPAN33
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN33
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN33 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33 |
Orthologs
for TSPAN33 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TSPAN33 gene from 1/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
tspan331 |
tetraspanin 33 |
73.21(n)
77.57(a) |
|
436890 NM_001002617.1 NP_001002617.1 |
ENSEMBL Gene Tree for TSPAN33 (if available)
TreeFam Gene Tree for TSPAN33 (if available) |
Paralogs
for TSPAN33 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSPAN33 gene
- TSPAN52 TSPAN172 TSPAN152 TSPAN142
16 SIMAP similar genes for TSPAN33 using alignment to 1 protein entry: TSN33_HUMAN:TM4SF17 TSPAN5 TM4SF9 TSPAN17 TSPAN15 TSPAN14
CD63 TSPAN10 TSPAN6 TSPAN8 TM4SF2 TSPAN7
CD151 CD82 TSPAN9 TSPAN4
TSPAN33 for paralogs About GeneDecksing
|
Genomic Variants
for TSPAN33 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSPAN33 (128784712 - 128809534 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSPAN33: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN33 |
|
Disorders
/ Diseases
for TSPAN33 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPAN33 for disorders About GeneDecksing
OMIM gene information: 610120
OMIM disorders: --
2  diseases for TSPAN33: About MalaCardscerebrovascular accident myeloid malignancy
Export disorders for TSPAN33 gene to outside databases
|
Publications
for TSPAN33 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPAN33 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPAN33) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies. (PubMed id 16213355)1, 2, 3 Chen Z.... Tsai S. (2005)
- Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. (PubMed id 17158226)1, 2 Heikens M.J.... Tsai S. (2007)
- The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms. (PubMed id 16242907)1, 3 Huang S....Xu A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Intron evolution: testing hypotheses of intron evolution using the phylogenomics of tetraspanins. (PubMed id 19262691)9 Garcia-EspaA+a A....Desalle R. (2009)
|
External Searches for TSPAN33 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSPAN33 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPAN33 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPAN33 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSPAN33 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSPAN33 gene:
Search GeneIP for patents involving TSPAN33
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPAN33 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSPAN33 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN33 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN33 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSPAN33 | | OriGene 3'-UTR Clone for TSPAN33 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN33 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN33 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSPAN33 | | OriGene Custom Protein Services for TSPAN33 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN33 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN33 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN33 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN33 |
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| |  |  |  |  | | | | |
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 | | | TSPAN33 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN33 |
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