TSPAN33 Gene

Aliases
for TSPAN33 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC07P128379 GC07P128571 GC07P123145

Summaries
for TSPAN33 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TSPAN33 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000007.13  NT_007933.16  NC_018918.2  

SwitchGear Promoter luciferase reporter plasmid: TSPAN33 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN33

TSPAN33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P128784:  view genomic region     (about GC identifiers)

Proteins
for TSPAN33 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TSPAN33: NX_Q86UF1

Explore proteomics data for TSPAN33 at MOPED

Post-translational modifications: 

TSPAN33 Human Recombinant Protein Products:

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	antibodies-online peptides for TSPAN33

TSPAN33 Antibody Products:

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	antibodies-online antibodies for TSPAN33 (16 products)

TSPAN33 Assay Products:

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	antibodies-online kits for TSPAN33 (6 products)

Domains /
Families
for TSPAN33 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q86UF1

Find genes that share domains with TSPAN33           About GenesLikeMe

Function
for TSPAN33 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tspan33):

genOway: Develop your customized and physiologically relevant rodent model for TSPAN33

miRNA Products:		miRTarBase miRNAs that target TSPAN33: hsa-mir-10b-5p (MIRT047482), hsa-mir-10a-5p (MIRT047718), hsa-mir-484 (MIRT042265)
		Block miRNA regulation of human, mouse, rat TSPAN33 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TSPAN33 (see all 29):
		hsa-miR-1287 hsa-miR-30c hsa-miR-875-3p hsa-miR-137 hsa-miR-30d hsa-miR-1265 hsa-miR-30a hsa-miR-149
		SwitchGear 3'UTR luciferase reporter plasmid: TSPAN33 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TSPAN33
		Predesigned siRNA for gene silencing in human, mouse, rat TSPAN33

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TSPAN33

Clone Products:		OriGene clones in human, mouse for TSPAN33 (see all 6) OriGene ORF clones in mouse, rat for TSPAN33 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TSPAN33 (NM_178562)
		Sino Biological Human cDNA Clone for TSPAN33
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN33
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN33

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TSPAN33
		Browse ESI BIO Cell Lines and PureStem Progenitors for TSPAN33

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33

Localization
for TSPAN33 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	3
cytoskeleton	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for TSPAN33 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for TSPAN33 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TSPAN33 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TSPAN33 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TSPAN33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCCTTGAATT

About this image

Blood (Hematopoietic System)
Proerythroblasts Hematopoietic Bone Marrow
Liver (Hepatobiliary System)
Kidney (Urinary System)

Primer Products:		OriGene qPCR primer pairs and template standards for TSPAN33 OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN33
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN33
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		QuantiFast Probe-based Assays in human, mouse, rat TSPAN33

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33

Orthologs
for TSPAN33 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TSPAN33 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TSPAN33 gene

CD151²  TSPAN5²  TSPAN10²  TSPAN17²  TSPAN6²  CD63²  TSPAN3²  TSPAN15²  

TSPAN7²  TSPAN11²  TSPAN14²  ENSG00000250349²  

15 SIMAP similar genes for TSPAN33 using alignment to 1 protein entry:     TSN33_HUMAN:

TM4SF17    TSPAN5    TM4SF9    TSPAN17    TSPAN15    TSPAN14

CD63    TSPAN10    TSPAN6    TSPAN8    TM4SF2    TSPAN7

CD151    CD82    TSPAN9

Find genes that share paralogs with TSPAN33           About GenesLikeMe

Genomic Variants
for TSPAN33 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TSPAN33 (see all 542)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1823860231,2		--	128166584(+)	CTAGCA/CAGGCA	1	--	us2k1		0	--	--	--	--
rs1878256061,2	C	--	128166596(+)	GGTGGC/TGGGCG	1	--	us2k1		0	--	--	--	--
rs1125745461,2	C,F	--	128166659(+)	GGAGGC/TGGAGG	1	--	us2k1		1		WA	2
rs803181311,2	C	--	128166797(+)	CTATC-/C/TTCCCC	1	--	us2k1		0	--	--	--	--
rs2008548941,2	C	--	128166799(+)	TATCC-/TCCCCG	1	--	us2k1		0	--	--	--	--
rs2022432111,2	C	--	128166799(+)	TATCCC/TCCCCG	1	--	us2k1		0	--	--	--	--
rs1925060181,2		--	128167008(+)	ACCACA/TGCCTA	1	--	us2k1		0	--	--	--	--
rs1444606721,2		--	128167082(+)	GTCTAC/TTACTC	1	--	us2k1		0	--	--	--	--
rs1832189661,2		--	128167089(+)	ACTCCC/TAAATC	1	--	us2k1		0	--	--	--	--
rs800153551,2	C	--	128167130(+)	AGCAGA/CATGCT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TSPAN33 (128784712 - 128809534 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TSPAN33:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv1096622	CNV	Insertion	17803354
nsv831127	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TSPAN33

DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN33

Disorders / Diseases
for TSPAN33 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TSPAN33 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TSPAN33 gene integrated from 10 sources: (articles sorted by number of sources associating them with TSPAN33)

Utopia: connect your pdf to the dynamic world of online information

1. The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies. (PubMed id 16213355)^{1, 2, 3} Chen Z.... Tsai S. (Cancer Genet. Cytogenet. 2005)
2. Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. (PubMed id 17158226)^{1, 2} Heikens M.J.... Tsai S. (Blood 2007)
3. The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms. (PubMed id 16242907)^{1, 3} Huang S....Xu A. (Genomics 2005)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. TSPAN33 is a novel marker of activated and malignant B cells. (PubMed id 24211713)¹ Luu V.P....Zlotnik A. (Clin. Immunol. 2013)
6. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)¹ Jostins L....Cho J.H. (Nature 2012)
7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)
8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)¹ Scherer S.W.... Tsui L.-C. (Science 2003)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Intron evolution: testing hypotheses of intron evolution using the phylogenomics of tetraspanins. (PubMed id 19262691)⁹ Garcia-EspaA+a A....Desalle R. (PLoS ONE 2009)

External Searches for TSPAN33 gene

Genome Databases showing TSPAN33 gene

Other Databases showing TSPAN33 gene

Specialized Databases showing TSPAN33 gene

Products
for TSPAN33 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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