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Aliases for TSPAN33 Gene

Aliases for TSPAN33 Gene

  • Tetraspanin 33 2 3 5
  • Proerythroblast New Membrane 3 4
  • TSPAN-33 3 4
  • Penumbra 3 4
  • PEN 3 4
  • PEN. 3
  • HPen 4

External Ids for TSPAN33 Gene

Previous GeneCards Identifiers for TSPAN33 Gene

  • GC07P128379
  • GC07P128571
  • GC07P128784
  • GC07P123145

Summaries for TSPAN33 Gene

GeneCards Summary for TSPAN33 Gene

TSPAN33 (Tetraspanin 33) is a Protein Coding gene. Diseases associated with TSPAN33 include Basilar Artery Occlusion and Heart Sarcoma. GO annotations related to this gene include enzyme binding. An important paralog of this gene is ENSG00000250349.

UniProtKB/Swiss-Prot for TSPAN33 Gene

  • Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN33 Gene

Genomics for TSPAN33 Gene

Regulatory Elements for TSPAN33 Gene

Enhancers for TSPAN33 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN33 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN33 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN33 Gene

129,144,716 bp from pter
129,169,697 bp from pter
24,982 bases
Plus strand

Genomic View for TSPAN33 Gene

Genes around TSPAN33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN33 Gene

Proteins for TSPAN33 Gene

  • Protein details for TSPAN33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for TSPAN33 Gene

    283 amino acids
    Molecular mass:
    31538 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for TSPAN33 Gene

Proteomics data for TSPAN33 Gene at MOPED

Post-translational modifications for TSPAN33 Gene

  • Glycosylation at Asn 172
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN33 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TSPAN33 Gene

Domains & Families for TSPAN33 Gene

Gene Families for TSPAN33 Gene

Protein Domains for TSPAN33 Gene

Suggested Antigen Peptide Sequences for TSPAN33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN33: view

Function for TSPAN33 Gene

Molecular function for TSPAN33 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors (By similarity).
genes like me logo Genes that share phenotypes with TSPAN33: view

Animal Models for TSPAN33 Gene

MGI Knock Outs for TSPAN33:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN33

miRNA for TSPAN33 Gene

miRTarBase miRNAs that target TSPAN33

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN33 Gene

Localization for TSPAN33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN33 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN33 Gene COMPARTMENTS Subcellular localization image for TSPAN33 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for TSPAN33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
GO:0005887 integral component of plasma membrane IBA --
GO:0097197 tetraspanin-enriched microdomain IEA --
genes like me logo Genes that share ontologies with TSPAN33: view

Pathways & Interactions for TSPAN33 Gene

SuperPathways for TSPAN33 Gene

No Data Available

Interacting Proteins for TSPAN33 Gene

Gene Ontology (GO) - Biological Process for TSPAN33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN33: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN33 Gene

Drugs & Compounds for TSPAN33 Gene

No Compound Related Data Available

Transcripts for TSPAN33 Gene

Unigene Clusters for TSPAN33 Gene

Tetraspanin 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN33 Gene

No ASD Table

Relevant External Links for TSPAN33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN33 Gene

mRNA expression in normal human tissues for TSPAN33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN33 Gene

This gene is overexpressed in Kidney - Cortex (x6.5).

Protein differential expression in normal tissues from HIPED for TSPAN33 Gene

This gene is overexpressed in Fetal Liver (33.8), Blymphocyte (15.2), Kidney (11.8), and Platelet (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TSPAN33 Gene

SOURCE GeneReport for Unigene cluster for TSPAN33 Gene Hs.27267

mRNA Expression by UniProt/SwissProt for TSPAN33 Gene

Tissue specificity: Predominantly expressed in erythroblasts.
genes like me logo Genes that share expression patterns with TSPAN33: view

Protein tissue co-expression partners for TSPAN33 Gene

Primer Products

Orthologs for TSPAN33 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN33 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN33 35
  • 91.17 (n)
  • 93.99 (a)
TSPAN33 36
  • 94 (a)
(Canis familiaris)
Mammalia TSPAN33 35
  • 92.46 (n)
  • 95.76 (a)
TSPAN33 36
  • 96 (a)
(Mus musculus)
Mammalia Tspan33 35
  • 90.69 (n)
  • 96.82 (a)
Tspan33 16
Tspan33 36
  • 97 (a)
(Pan troglodytes)
Mammalia TSPAN33 35
  • 100 (n)
  • 100 (a)
TSPAN33 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan33 35
  • 90.34 (n)
  • 97.17 (a)
(Monodelphis domestica)
Mammalia TSPAN33 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN33 36
  • 82 (a)
(Gallus gallus)
Aves -- 36
  • 28 (a)
(Anolis carolinensis)
Reptilia TSPAN33 36
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan33 35
  • 75.44 (n)
  • 83.99 (a)
(Danio rerio)
Actinopterygii tspan33 35
  • 73.21 (n)
  • 77.57 (a)
tspan33 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002257 35
  • 54.68 (n)
  • 43.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp86D 35
  • 55.04 (n)
  • 43.68 (a)
Tsp3A 36
  • 36 (a)
Tsp86D 36
  • 38 (a)
Species with no ortholog for TSPAN33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN33 Gene

Gene Tree for TSPAN33 (if available)
Gene Tree for TSPAN33 (if available)

Paralogs for TSPAN33 Gene

(15) SIMAP similar genes for TSPAN33 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN33: view

Variants for TSPAN33 Gene

Sequence variations from dbSNP and Humsavar for TSPAN33 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs919551 -- 129,163,095(-) ACCTT(A/G)TGATC intron-variant
rs968367 -- 129,151,008(+) AGATA(C/T)TTCCT intron-variant
rs6949275 -- 129,159,141(+) ctgca(A/T)cctct intron-variant
rs6949284 -- 129,159,146(+) tcctc(C/T)gcctc intron-variant
rs6949483 -- 129,159,305(+) ccacc(C/T)gcttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN33 Gene

Variant ID Type Subtype PubMed ID
nsv831127 CNV Gain 17160897
esv1096622 CNV Insertion 17803354

Variation tolerance for TSPAN33 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN33 Gene

Disorders for TSPAN33 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TSPAN33 Gene - From: DISEASES

Disorder Aliases PubMed IDs
basilar artery occlusion
heart sarcoma
  • cardiac sarcoma
subdural empyema
  • subdural abscess
stroke, ischemic
  • ischemic stroke
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSPAN33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN33 Gene

Publications for TSPAN33 Gene

  1. The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies. (PMID: 16213355) Chen Z. … Tsai S. (Cancer Genet. Cytogenet. 2005) 2 3 4 67
  2. The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms. (PMID: 16242907) Huang S. … Xu A. (Genomics 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TSPAN33 is a novel marker of activated and malignant B cells. (PMID: 24211713) Luu V.P. … Zlotnik A. (Clin. Immunol. 2013) 3
  5. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E. … Rubinstein E. (J. Cell Biol. 2012) 3

Products for TSPAN33 Gene

Sources for TSPAN33 Gene