Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPAN33 Gene

protein-coding   GIFtS: 47
GCID: GC07P128784

Tetraspanin 33
  See related disease
at
MalaCards
 

Aliases
for TSPAN33 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Tetraspanin 331 2     tetraspanin-332
Proerythroblast New Membrane2 3     tspan-332
PEN2 3     Penumbra3
hPen2 3     Tspan-333
penumbra2     

External Ids:    HGNC: 287431   Entrez Gene: 3403482   Ensembl: ENSG000001584577   OMIM: 6101205   UniProtKB: Q86UF13   

Export aliases for TSPAN33 gene to outside databases

Previous GC identifers: GC07P128379 GC07P128571 GC07P123145


Summaries
for TSPAN33 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for TSPAN33 Gene: 
TSPAN33 (tetraspanin 33) is a protein-coding gene. Diseases associated with TSPAN33 include cerebrovascular accident. An important paralog of this gene is TSPAN5.

UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1
Function: Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid
progenitors (By similarity)




Genomic Views
for TSPAN33 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPAN33 gene promoter:
         STAT1   GATA-3   STAT1beta   NF-kappaB   Arnt   GATA-1   GATA-2   STAT1alpha   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSPAN33 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPAN33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32.3

TSPAN33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN33 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P128784:  view genomic region     (about GC identifiers)

Start:
 128,784,712 bp from pter      End:
 128,809,534 bp from pter
Size:
 24,823 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 128,168,549-128,193,491     

Proteins
for TSPAN33 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1 (See protein sequence)
Recommended Name: Tetraspanin-33  
Size: 283 amino acids; 31538 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for TSPAN33: NX_Q86UF1

Explore proteomics data for TSPAN33 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UF1

    • TSPAN33 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSPAN33 Protein Expression
    REFSEQ proteins: NP_848657.1  
    ENSEMBL proteins: 
     ENSP00000289407  

    Human Recombinant Protein Products for TSPAN33: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TSPAN33
    GenScript Custom Purified and Recombinant Proteins Services for TSPAN33
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSPAN33 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TSPAN33 for ontologies           About GeneDecksing



    TSPAN33 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSPAN33
    GenScript Custom Superior Antibodies Services for TSPAN33
    Novus Biologicals TSPAN33 Antibodies
    Abcam antibodies for TSPAN33
    Cloud-Clone Corp. Antibodies for TSPAN33 
    ThermoFisher Antibody for TSPAN33
    LSBio Antibodies in human, mouse, rat for TSPAN33 

    Assay Products for TSPAN33: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSPAN33
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSPAN33
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSPAN33 
    Cloud-Clone Corp. CLIAs for TSPAN33

    Protein Domains /
    Families
    for TSPAN33 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    TSPAN: Tetraspanins

    3 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2

    Graphical View of Domain Structure for InterPro Entry Q86UF1

    ProtoNet protein and cluster: Q86UF1

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1
    Similarity: Belongs to the tetraspanin (TM4SF) family


    TSPAN33 for domains           About GeneDecksing


    Function
    for TSPAN33 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSN33_HUMAN, Q86UF1
    Function: Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid
    progenitors (By similarity)

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tspan33):

     hematopoietic system  immune system  tumorigenesis 

    TSPAN33 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tspan33tm1Stsa for TSPAN33

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPAN33 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPAN33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPAN33 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPAN33 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN33
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN33 (see all 29):
    hsa-miR-1287 hsa-miR-30c hsa-miR-875-3p hsa-miR-137 hsa-miR-30d hsa-miR-1265 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: TSPAN33 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSPAN33
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN33

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TSPAN33
    Sirion Biotech Customized adenovirus for overexpression of TSPAN33

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TSPAN33 (see all 7)
    OriGene ORF clones in mouse, rat for TSPAN33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN33 (NM_178562)
    Sino Biological Human cDNA Clone for TSPAN33
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN33
    Sirion Biotech Customized lentivirus for stable overexpression of TSPAN33 
                         Customized lentivirus expression plasmids for stable overexpression of TSPAN33 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TSPAN33
    Search LifeMap BioReagents cell lines for TSPAN33
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33


    Pathways & Interactions
    for TSPAN33 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN33

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TSPAN33 (ENSP000002894074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA8ENSP000003673164STRING: ENSP00000367316
    ITGAXENSP000002682964STRING: ENSP00000268296
    ITGB2ENSP000003032424STRING: ENSP00000303242
    About this table

    Drugs & Compounds
    for TSPAN33 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSPAN33 (TSN33)

    Search CenterWatch for drugs/clinical trials and news about TSPAN33 / TSN33

    Transcripts
    for TSPAN33 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSPAN33 gene: 
    NM_178562.3  

    Unigene Cluster for TSPAN33:

    Tetraspanin 33
    Hs.27267  [show with all ESTs]
    Unigene Representative Sequence: NM_178562
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289407(uc003vop.2) ENST00000496963 ENST00000486685(uc003voq.2)

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN33
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN33 (see all 29):
    hsa-miR-1287 hsa-miR-30c hsa-miR-875-3p hsa-miR-137 hsa-miR-30d hsa-miR-1265 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: TSPAN33 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSPAN33
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN33
    Clone
    Products:             		 OriGene clones in human, mouse for TSPAN33 (see all 7)
    OriGene ORF clones in mouse, rat for TSPAN33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN33 (NM_178562)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN33
    Sirion Biotech Customized lentivirus for stable overexpression of TSPAN33 
                         Customized lentivirus expression plasmids for stable overexpression of TSPAN33 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for TSPAN33
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN33
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN33
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN33
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN33

    Additional mRNA sequence: 

    AF276891.1 AY236849.1 BC044244.1 

    5 DOTS entries:

    DT.315426  DT.315427  DT.100814132  DT.95160864  DT.40310326 

    24/119 AceView cDNA sequences (see all 119):

    AA917873 BM714582 BQ708420 BX093063 AI078627 BM675347 W95735 CA311002 
    AI217778 AA232951 AA631017 AA456896 AW026287 AA768759 BF724098 AW001670 
    AA827439 BQ684452 CR609044 CA309092 AA715038 AA485019 BX280316 BP872796 

    GeneLoc Exon Structure


    Expression
    for TSPAN33 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSPAN33 expression in normal human tissues (normalized intensities)      TSPAN33 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTGAATT
    TSPAN33 Expression
    About this image


    TSPAN33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)

    See TSPAN33 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSPAN33

    SOURCE GeneReport for Unigene cluster: Hs.27267

    UniProtKB/Swiss-Prot: TSN33_HUMAN, Q86UF1
    Tissue specificity: Predominantly expressed in erythroblasts

        SABiosciences Custom PCR Arrays for TSPAN33
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for TSPAN33
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN33
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN33
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN33
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN33
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33

    Orthologs
    for TSPAN33 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN33 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tspan331 , 5 tetraspanin 331, 5 90.69(n)1
    96.82(a)1    		   6 (12.36 cM)5
    2326701  NM_146173.21  NP_666285.11 
     296942225 
    lizard
    (Anolis carolinensis)    		 Reptilia TSPAN336
    TSPAN336
    		 tetraspanin 33
    		 92(a)
    38(a)
    		 possible ortholog
    1 ↔ 1
    		 GL343653.1(416-7208)
    GL343993.1(98110-113242)
    zebrafish
    (Danio rerio)    		 Actinopterygii tspan331 tetraspanin 33 73.21(n)
    77.57(a)    		   436890  NM_001002617.1  NP_001002617.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tsp86D6
    Tsp3A6
    		 Tetraspanin 3A
    		 37(a)
    34(a)
    		 many ↔ many
    many ↔ many
    		 3R(6694435-6696277)
    X(2511791-2513771)
    worm
    (Caenorhabditis elegans)    		 Secernentea tsp-116
    tsp-216
    		 Protein TSP-21
    		 18(a)
    17(a)
    		 possible ortholog
    possible ortholog
    		 X(9163164-9166007)
    X(9933247-9937133)


    ENSEMBL Gene Tree for TSPAN33 (if available)
    TreeFam Gene Tree for TSPAN33 (if available)

    Paralogs
    for TSPAN33 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSPAN33 gene
    TSPAN52  TSPAN172  TSPAN102  TSPAN152  TSPAN142  
    15 SIMAP similar genes for TSPAN33 using alignment to 1 protein entry:     TSN33_HUMAN:
    TM4SF17    TSPAN5    TM4SF9    TSPAN17    TSPAN15    TSPAN14
    CD63    TSPAN10    TSPAN6    TSPAN8    TM4SF2    TSPAN7
    CD151    CD82    TSPAN9

    TSPAN33 for paralogs           About GeneDecksing



    Genomic Variants
    for TSPAN33 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/542 SNPs in TSPAN33 are shown (see all 542)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1823860231,2
    		--128166584(+) CTAGCA/CAGGCA 1 -- us2k10--------
    rs1878256061,2
    		C--128166596(+) GGTGGC/TGGGCG 1 -- us2k10--------
    rs1125745461,2
    		C,F--128166659(+) GGAGGC/TGGAGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs803181311,2
    		C--128166797(+) CTATC-/C/TTCCCC 1 -- us2k10--------
    rs2008548941,2
    		C--128166799(+) TATCC-/TCCCCG 1 -- us2k10--------
    rs2022432111,2
    		C--128166799(+) TATCCC/TCCCCG 1 -- us2k10--------
    rs1925060181,2
    		--128167008(+) ACCACA/TGCCTA 1 -- us2k10--------
    rs1444606721,2
    		--128167082(+) GTCTAC/TTACTC 1 -- us2k10--------
    rs1832189661,2
    		--128167089(+) ACTCCC/TAAATC 1 -- us2k10--------
    rs800153551,2
    		C--128167130(+) AGCAGA/CATGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSPAN33 (128784712 - 128809534 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSPAN33:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1096622CNV Insertion17803354
    nsv831127CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPAN33
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN33

    Disorders / Diseases
    for TSPAN33 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 610120    OMIM disorders: --

    2 diseases for TSPAN33:    About MalaCards
    cerebrovascular accident    


    TSPAN33 for disorders           About GeneDecksing


    Export disorders for TSPAN33 gene to outside databases

    Publications
    for TSPAN33 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSPAN33 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TSPAN33)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies. (PubMed id 16213355)1, 2, 3 Chen Z.... Tsai S. (2005)
    2. Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. (PubMed id 17158226)1, 2 Heikens M.J.... Tsai S. (2007)
    3. The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms. (PubMed id 16242907)1, 3 Huang S....Xu A. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Intron evolution: testing hypotheses of intron evolution using the phylogenomics of tetraspanins. (PubMed id 19262691)9 Garcia-EspaA+a A....Desalle R. (2009)

    External Searches for TSPAN33 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TSPAN33 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340348 HGNC: 28743 AceView: MGC50844 Ensembl:ENSG00000158457 euGenes: HUgn340348
    ECgene: TSPAN33 H-InvDB: TSPAN33

    Other Databases showing TSPAN33 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TSPAN33 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSPAN33 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TSPAN33 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TSPAN33 gene:
    Search GeneIP for patents involving TSPAN33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TSPAN33 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSPAN33  
     OriGene qPCR primer pairs and template standards for TSPAN33   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TSPAN33  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN33   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TSPAN33   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSPAN33   OriGene Custom Protein Services for TSPAN33  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN33
     QIAGEN SeqTarget long-range PCR primers for resequencing TSPAN33
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN33
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN33
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN33
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN33
     GenScript Custom Purified and Recombinant Proteins Services for TSPAN33 GenScript cDNA clones with any tag delivered in your preferred vector for TSPAN33
     GenScript Custom Assay Services for TSPAN33 GenScript Custom Superior Antibodies Services for TSPAN33
     GenScript Custom overexpressing Cell Line Services for TSPAN33 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSPAN33 promoter
     Search Chromatin IP Primers for TSPAN33
     RT2 qPCR Primer Assay in human, mouse, rat TSPAN33
     Search GNC Networks for TSPAN33
     SABiosciences Custom PCR Arrays for TSPAN33
     Search Tocris compounds for TSPAN33 (TSN33)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for TSPAN33
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSPAN33 antibodies
     Antibodies for TSPAN33
     See all of Abcam's Antibodies, Kits and Proteins for TSPAN33
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TSPAN33
     Antibodies for TSPAN33
     ELISAs for TSPAN33
     CLIAs for TSPAN33
     Search LifeMap BioReagents cell lines for TSPAN33
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN33
     SwitchGear 3'UTR luciferase reporter plasmids for TSPAN33
     SwitchGear Promoter luciferase reporter plasmids for TSPAN33
     ThermoFisher Antibody for TSPAN33
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN33
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPAN33
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPAN33
    Customized:
     lentivirus for stable overexpression of TSPAN33
     lentivirus expression plasmids for stable overexpression of TSPAN33
     adenovirus for overexpression of TSPAN33
     LSBio Antibodies in human, mouse, rat for TSPAN33
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TSPAN33 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4