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Aliases for TSPAN33 Gene

Aliases for TSPAN33 Gene

  • Tetraspanin 33 2 3 5
  • Proerythroblast New Membrane 3 4
  • TSPAN-33 3 4
  • Penumbra 3 4
  • PEN 3 4
  • Tetraspanin-33 3
  • PEN. 3
  • HPen 4

External Ids for TSPAN33 Gene

Previous GeneCards Identifiers for TSPAN33 Gene

  • GC07P128379
  • GC07P128571
  • GC07P128784
  • GC07P123145

Summaries for TSPAN33 Gene

GeneCards Summary for TSPAN33 Gene

TSPAN33 (Tetraspanin 33) is a Protein Coding gene. Diseases associated with TSPAN33 include Basilar Artery Occlusion and Heart Sarcoma. GO annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN17.

UniProtKB/Swiss-Prot for TSPAN33 Gene

  • Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN33 Gene

Genomics for TSPAN33 Gene

Regulatory Elements for TSPAN33 Gene

Enhancers for TSPAN33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G129099 1.3 Ensembl ENCODE 24.6 -42.7 -42672 4.4 HDGF HNRNPUL1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 TSPAN33 TNPO3 ENSG00000242162 TPI1P2 ENSG00000243679 ENSG00000230715 ENSG00000243302 RBM28 ENSG00000242588 ATP6V1F
GH07G129122 1.5 FANTOM5 ENCODE dbSUPER 13 -21.9 -21891 1.6 TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 YBX1 CBX5 ZNF207 RCOR1 RELB TNPO3 TSPAN33 ENSG00000242162 TPI1P2 ENSG00000243230 AHCYL2 ATP6V1F NRF1 LOC407835 CYCSP20
GH07G128932 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -210.3 -210276 3.3 HDGF TBP PKNOX1 WRNIP1 SIN3A ZBTB40 ZNF143 RELB ETV6 IKZF2 IRF5 ATP6V1F KCP ENSG00000242162 FLNC FLNC-AS1 TSPAN33 TNPO3 TPI1P2 LOC392787
GH07G129091 1.2 Ensembl ENCODE 11.5 -53.1 -53095 1.0 HDGF FOXA2 PKNOX1 ARNT ARID4B GATA2 ELK1 ZNF143 DEK REST TNPO3 SMO TSPAN33 TPI1P2 IRF5 ENSG00000241102 ENSG00000242162
GH07G129150 1.2 ENCODE dbSUPER 10.8 +5.7 5719 0.2 CREB3L1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 NCOA1 MEF2D MBD2 TSPAN33 GC07P129165
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN33 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217825 84 1201 PKNOX1 FOXA2 ZSCAN4 INSM2 ARID4B ZNF76 SIN3A ZNF2 GLIS2 EGR1

Genomic Location for TSPAN33 Gene

Chromosome:
7
Start:
129,144,716 bp from pter
End:
129,169,697 bp from pter
Size:
24,982 bases
Orientation:
Plus strand

Genomic View for TSPAN33 Gene

Genes around TSPAN33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN33 Gene

Proteins for TSPAN33 Gene

  • Protein details for TSPAN33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UF1-TSN33_HUMAN
    Recommended name:
    Tetraspanin-33
    Protein Accession:
    Q86UF1

    Protein attributes for TSPAN33 Gene

    Size:
    283 amino acids
    Molecular mass:
    31538 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:17158226). Interacts with ADAM10 (PubMed:26686862).

neXtProt entry for TSPAN33 Gene

Post-translational modifications for TSPAN33 Gene

  • Glycosylation at isoforms=172
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPAN33 Gene

Domains & Families for TSPAN33 Gene

Gene Families for TSPAN33 Gene

Protein Domains for TSPAN33 Gene

Suggested Antigen Peptide Sequences for TSPAN33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UF1

UniProtKB/Swiss-Prot:

TSN33_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN33: view

Function for TSPAN33 Gene

Molecular function for TSPAN33 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).

Gene Ontology (GO) - Molecular Function for TSPAN33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN33: view
genes like me logo Genes that share phenotypes with TSPAN33: view

Animal Models for TSPAN33 Gene

MGI Knock Outs for TSPAN33:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN33

CRISPR Products

miRNA for TSPAN33 Gene

miRTarBase miRNAs that target TSPAN33

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN33 Gene

Localization for TSPAN33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN33 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN33 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN33: view

Pathways & Interactions for TSPAN33 Gene

SuperPathways for TSPAN33 Gene

No Data Available

Interacting Proteins for TSPAN33 Gene

Selected Interacting proteins: Q86UF1-TSN33_HUMAN for TSPAN33 Gene via IID

Gene Ontology (GO) - Biological Process for TSPAN33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0051604 protein maturation IDA 23091066
GO:0090002 establishment of protein localization to plasma membrane IDA 23091066
genes like me logo Genes that share ontologies with TSPAN33: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN33 Gene

Drugs & Compounds for TSPAN33 Gene

No Compound Related Data Available

Transcripts for TSPAN33 Gene

Unigene Clusters for TSPAN33 Gene

Tetraspanin 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN33 Gene

No ASD Table

Relevant External Links for TSPAN33 Gene

GeneLoc Exon Structure for
TSPAN33
ECgene alternative splicing isoforms for
TSPAN33

Expression for TSPAN33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN33 Gene

This gene is overexpressed in Kidney - Cortex (x6.5).

Protein differential expression in normal tissues from HIPED for TSPAN33 Gene

This gene is overexpressed in Fetal Liver (33.8), Blymphocyte (15.2), Kidney (11.8), and Platelet (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN33 Gene



Protein tissue co-expression partners for TSPAN33 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN33 Gene:

TSPAN33

SOURCE GeneReport for Unigene cluster for TSPAN33 Gene:

Hs.27267

mRNA Expression by UniProt/SwissProt for TSPAN33 Gene:

Q86UF1-TSN33_HUMAN
Tissue specificity: Predominantly expressed in erythroblasts.

Evidence on tissue expression from TISSUES for TSPAN33 Gene

  • Intestine(4.3)
  • Bone marrow(4.1)
  • Nervous system(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TSPAN33: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN33 Gene

Orthologs for TSPAN33 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN33 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia TSPAN33 34 35
  • 92.46 (n)
cow
(Bos Taurus)
Mammalia TSPAN33 34 35
  • 91.17 (n)
mouse
(Mus musculus)
Mammalia Tspan33 34 16 35
  • 90.69 (n)
rat
(Rattus norvegicus)
Mammalia Tspan33 34
  • 90.34 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPAN33 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN33 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TSPAN33 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan33 34
  • 75.44 (n)
zebrafish
(Danio rerio)
Actinopterygii tspan33 34 35
  • 73.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp86D 34 35
  • 55.04 (n)
Tsp3A 35
  • 36 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002257 34
  • 54.68 (n)
Species where no ortholog for TSPAN33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN33 Gene

ENSEMBL:
Gene Tree for TSPAN33 (if available)
TreeFam:
Gene Tree for TSPAN33 (if available)

Paralogs for TSPAN33 Gene

(15) SIMAP similar genes for TSPAN33 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN33: view

Variants for TSPAN33 Gene

Sequence variations from dbSNP and Humsavar for TSPAN33 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000094104 -- 129,165,418(+) CTTTT(C/T)TGAGT intron-variant
rs1000308064 -- 129,155,077(+) CAGCC(A/C)TAAAA intron-variant
rs1000423534 -- 129,165,761(+) AAAAA(G/T)TAGCC intron-variant
rs1000943825 -- 129,146,528(+) AACCA(C/T)AGTGC intron-variant
rs1001009703 -- 129,146,216(+) AAAGG(C/T)TTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN33 Gene

Variant ID Type Subtype PubMed ID
nsv831127 CNV gain 17160897

Variation tolerance for TSPAN33 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN33 Gene

Disorders for TSPAN33 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TSPAN33 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
basilar artery occlusion
heart sarcoma
  • cardiac sarcoma
subdural empyema
  • subdural abscess
stroke, ischemic
  • ischemic stroke
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN33
genes like me logo Genes that share disorders with TSPAN33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN33 Gene

Publications for TSPAN33 Gene

  1. The human Penumbra gene is mapped to a region on chromosome 7 frequently deleted in myeloid malignancies. (PMID: 16213355) Chen Z. … Tsai S. (Cancer Genet. Cytogenet. 2005) 2 3 4 64
  2. Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. (PMID: 17158226) Heikens M.J. … Tsai S. (Blood 2007) 3 4 64
  3. The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms. (PMID: 16242907) Huang S. … Xu A. (Genomics 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. (PMID: 26686862) Jouannet S. … Rubinstein E. (Cell. Mol. Life Sci. 2016) 4 64

Products for TSPAN33 Gene

Sources for TSPAN33 Gene

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