TSPAN32 Gene
protein-coding GIFtS : 49 GCID: GC11 P002323
tetraspanin 32 pan-hematopoietic expression )TSSC6, PHEMX )
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Aliasesfor TSPAN32 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tetraspanin 32 1 2 Pan-Hematopoietic Expression Protein2 PHEMX1 2 3 5 Tetraspanin-321 TSSC61 2 3 5 Tspan-323 Protein Phemx2 3 Tumor-Suppressing STF CDNA 62 Pan-Hematopoietic Expression1 Tumor-Suppressing Subchromosomal Transferable Fragment CDNA 62 ART12 Tumor-Suppressing Subtransferable Candidate 62 PHMX2 Tspan-323
Export aliases for TSPAN32 gene to outside databases Previous GC identifers: GC11P002280 GC11P002113
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Summariesfor TSPAN32 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TSPAN32 : This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008) Gene Wiki entry for TSPAN32
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Genomic Viewsfor TSPAN32 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TSPAN32 gene promoter:Elk-1 RP58 GATA-3 NCX/Ncx MyoD CREB GATA-6 deltaCREB HOXA5 TGIF Other transcription factors Search SABiosciences Chromatin IP Primers for TSPAN32 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN32
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15 TSPAN32 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P002323: view genomic region
(about GC identifiers )
Start: 2,323,227 bp from pter End:
2,339,430 bp from pter
Size: 16,204 bases Orientation:
plus strand
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Proteinsfor TSPAN32 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1 See
protein sequence )Recommended Name: Size : 320 amino acids; 34631 DaSubcellular location : Membrane; Multi-pass membrane protein (Potential)Developmental stage : Expressed from early embryogenesis through to adulthoodSecondary accessions : Q96KX4 Q9HC50 Q9HC51 Q9Y5U1Alternative splicing : 5 isoforms : Q96QS1-1 Q96QS1-2 Q96QS1-3 Q96QS1-4 Q96QS1-5 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for TSPAN32: NX_Q96QS1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96QS1 TSPAN32 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_620591.3 ENSEMBL proteins: ENSP00000405001 ENSP00000182290 ENSP00000395018 ENSP00000370513 ENSP00000343285 ENSP00000405205 ENSP00000388033 ENSP00000370509 Human Recombinant Protein Products for TSPAN32: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA -- GO:0016021 integral to membrane
NAS --
About GeneDecksing TSPAN32 Antibody Products: Assay Products for TSPAN32:
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Protein
Domains /for TSPAN32 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96QS1 ProtoNet protein and cluster: Q96QS1
UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1 Similarity : Belongs to the tetraspanin (TM4SF) family
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Functionfor TSPAN32 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
About GeneDecksing Phenotypes: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tspan32) :About GeneDecksing Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPAN32 (NM_139022 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN32 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN32
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32
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Pathways & Interactionsfor TSPAN32 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN32 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
About GeneDecksing
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Drugs & Compoundsfor TSPAN32 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for TSPAN32 7 Novoseek chemical compound relationships for TSPAN32 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
ganglioside
44.3
4
15334254 (1), 12068006 (1), 15710618 (1), 19559406 (1)
tyrosine
31
6
10427099 (1), 12938224 (1), 12110679 (1), 19166707 (1) (see all 5 )
lipid
27.3
9
15454569 (1), 15496196 (1), 16785325 (1), 19497983 (1) (see all 9 )
phosphatidylinositol
23.4
2
12110679 (1), 11739647 (1)
cysteine
23.2
5
20171294 (2), 11907260 (1), 14556650 (1), 12575999 (1)
cholesterol
5.22
23
12938224 (5), 15184367 (2), 15454569 (1), 19497983 (1) (see all 5 )
polysaccharide
0
1
12701754 (1)
TSPAN32 / TSN32
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Transcriptsfor TSPAN32 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TSPAN32 gene (3 alternative transcripts): NM_139022.2 NM_005705.4 NM_139024.3 Unigene Cluster for TSPAN32:
Tetraspanin 32 Hs.271954 [show with all ESTs ] Unigene Representative Sequence: AK298692 18 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000437313 ENST00000461200 (uc001lvx.1 uc009ydk.1 uc010qxk.2 uc001lvy.1 uc009ydl.1 uc001lwb.1 uc001lwc.1 uc001lwd.1 )ENST00000182290 ENST00000446063 ENST00000493924 ENST00000484104 ENST00000479508 ENST00000498313 ENST00000483227 ENST00000381121 ENST00000493948 ENST00000339046 ENST00000451520 (uc001lvz.1 ) ENST00000444307 ENST00000468578 ENST00000381117 ENST00000484523 ENST00000486011 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPAN32 (NM_139022 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN32 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN32
Additional cDNA sequence: AF176071.1 AK298692.1 AK307638.1 AK310116.1 AY039001.1 AY303780.1 BC016693.1
11 DOTS entries : DT.95168325 DT.111418
DT.95094062 DT.111419 DT.91648803 DT.97812022 DT.91656368 DT.120684722 DT.95168321 DT.95168322 DT.40314344 24/49 AceView cDNA sequences (see all 49 ):
AW440888 AA701395 BI906333 AY039001 AF176070 BX117724 NM_139024 NM_139022 CR606621 BG506933 AF125569 AA913945 N99620 BI909345 BI907377 AK128812 NM_005705 AF176071 BI518496 AY303780 BC016693 BI909447 BV196160 BM926073 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN32 (see all 12 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c SP1 : - - - - - - - - SP2 : - - - - - - - - - SP3 : - - - - - - SP4 : - - - - - SP5 : - - - - - -
ECgene alternative splicing isoforms for TSPAN32
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Expression for TSPAN32 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TSPAN32 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTGTAGGACAbout this image TSPAN32 expression in embryonic tissues and stem cells About this table
See TSPAN32 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSPAN32 SOURCE GeneReport for Unigene cluster: Hs.271954 UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1 Tissue specificity : Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietictissues including peripheral blood leukocytes, thymus and spleen SABiosciences Custom PCR Arrays for TSPAN32 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32
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Orthologsfor TSPAN32 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for TSPAN32 gene from 3/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for TSPAN32 (if available)TreeFam Gene Tree for TSPAN32 (if available)
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Paralogsfor TSPAN32 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor TSPAN32 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization