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Aliases for TSPAN32 Gene

Aliases for TSPAN32 Gene

  • Tetraspanin 32 2 3 5
  • Protein Phemx 3 4
  • PHEMX 3 4
  • TSSC6 3 4
  • Tumor-Suppressing Subchromosomal Transferable Fragment CDNA 6 3
  • Tumor-Suppressing Subtransferable Candidate 6 3
  • Pan-Hematopoietic Expression Protein 3
  • Pan-Hematopoietic Expression 2
  • Tumor-Suppressing STF CDNA 6 3
  • Tetraspanin-32 3
  • Tspan-32 4
  • ART1 3
  • PHMX 3

External Ids for TSPAN32 Gene

Previous HGNC Symbols for TSPAN32 Gene

  • TSSC6
  • PHEMX

Previous GeneCards Identifiers for TSPAN32 Gene

  • GC11P002280
  • GC11P002113
  • GC11P002323

Summaries for TSPAN32 Gene

Entrez Gene Summary for TSPAN32 Gene

  • This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN32 Gene

TSPAN32 (Tetraspanin 32) is a Protein Coding gene. Diseases associated with TSPAN32 include Beckwith-Wiedemann Syndrome.

Gene Wiki entry for TSPAN32 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN32 Gene

Genomics for TSPAN32 Gene

Regulatory Elements for TSPAN32 Gene

Enhancers for TSPAN32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G002300 1.3 ENCODE dbSUPER 18.2 +2.4 2355 7.9 HDGF PKNOX1 CREB3L1 ARNT YY1 ZNF766 ZNF143 FOS ZNF263 REST C11orf21 TSPAN32 RNU6-878P
GH11G002212 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -88.3 -88300 2.3 ELF3 TBP FOXA2 PKNOX1 MLX RAD21 DNMT3B THRB ZNF48 RARA TSPAN32 ASCL2 TH GC11M002206 GC11M002224
GH11G002298 0.9 Ensembl ENCODE 21.3 -2.5 -2468 1.3 CTCF MAZ REST ZNF48 RAD21 KAT8 KLF16 MXD3 SMC3 HNF4A TSPAN32 C11orf21 PIR61836
GH11G002209 1.2 ENCODE dbSUPER 12 -91.5 -91451 2.9 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 SP5 ZHX2 MXD4 NFYC C11orf21 TSPAN32 TH ENSG00000236710 GC11M002206 MIR4686
GH11G001985 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.5 -309.4 -309432 14.6 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 ARID4B DMAP1 SLC30A9 MRPL23-AS1 IGF2 TSPAN32 SYT8 ENSG00000275266 LINC01219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN32 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035923 3 401 HDGF PKNOX1 TCF12 ZNF766 GATA2 EGR1 CREM ZBTB11 ELF1 ZNF589

Genomic Location for TSPAN32 Gene

Chromosome:
11
Start:
2,301,997 bp from pter
End:
2,318,201 bp from pter
Size:
16,205 bases
Orientation:
Plus strand

Genomic View for TSPAN32 Gene

Genes around TSPAN32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN32 Gene

Proteins for TSPAN32 Gene

  • Protein details for TSPAN32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QS1-TSN32_HUMAN
    Recommended name:
    Tetraspanin-32
    Protein Accession:
    Q96QS1
    Secondary Accessions:
    • Q96KX4
    • Q9HC50
    • Q9HC51
    • Q9Y5U1

    Protein attributes for TSPAN32 Gene

    Size:
    320 amino acids
    Molecular mass:
    34631 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN32 Gene

Post-translational modifications for TSPAN32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSPAN32 Gene

Domains & Families for TSPAN32 Gene

Gene Families for TSPAN32 Gene

Protein Domains for TSPAN32 Gene

Suggested Antigen Peptide Sequences for TSPAN32 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QS1

UniProtKB/Swiss-Prot:

TSN32_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN32: view

Function for TSPAN32 Gene

Gene Ontology (GO) - Molecular Function for TSPAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TSPAN32: view
genes like me logo Genes that share phenotypes with TSPAN32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN32

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN32 Gene

Localization for TSPAN32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN32 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN32 gene
Compartment Confidence
plasma membrane 4
extracellular 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TSPAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN32: view

Pathways & Interactions for TSPAN32 Gene

SuperPathways for TSPAN32 Gene

No Data Available

Interacting Proteins for TSPAN32 Gene

Gene Ontology (GO) - Biological Process for TSPAN32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007267 cell-cell signaling TAS 10950922
GO:0007596 blood coagulation IEA --
genes like me logo Genes that share ontologies with TSPAN32: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN32 Gene

Drugs & Compounds for TSPAN32 Gene

(3) Drugs for TSPAN32 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TSPAN32 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSPAN32: view

Transcripts for TSPAN32 Gene

Unigene Clusters for TSPAN32 Gene

Tetraspanin 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - - - -
SP12: - -

Relevant External Links for TSPAN32 Gene

GeneLoc Exon Structure for
TSPAN32
ECgene alternative splicing isoforms for
TSPAN32

Expression for TSPAN32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN32 Gene

This gene is overexpressed in Whole Blood (x20.8), Heart - Left Ventricle (x5.0), and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for TSPAN32 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and Platelet (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN32 Gene



Protein tissue co-expression partners for TSPAN32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSPAN32 Gene:

TSPAN32

SOURCE GeneReport for Unigene cluster for TSPAN32 Gene:

Hs.271954

mRNA Expression by UniProt/SwissProt for TSPAN32 Gene:

Q96QS1-TSN32_HUMAN
Tissue specificity: Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen.

Evidence on tissue expression from TISSUES for TSPAN32 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with TSPAN32: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN32 Gene

Orthologs for TSPAN32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSPAN32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN32 34
  • 93.65 (n)
dog
(Canis familiaris)
Mammalia TSPAN32 34 35
  • 77.58 (n)
rat
(Rattus norvegicus)
Mammalia Phemx 34
  • 76.32 (n)
mouse
(Mus musculus)
Mammalia Tspan32 34 16 35
  • 76.02 (n)
cow
(Bos Taurus)
Mammalia TSPAN32 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN32 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN32 34 35
  • 60.54 (n)
lizard
(Anolis carolinensis)
Reptilia TSPAN32 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan32 34
  • 46.58 (n)
Species where no ortholog for TSPAN32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSPAN32 Gene

ENSEMBL:
Gene Tree for TSPAN32 (if available)
TreeFam:
Gene Tree for TSPAN32 (if available)

Paralogs for TSPAN32 Gene

(1) SIMAP similar genes for TSPAN32 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSPAN32: view

No data available for Paralogs for TSPAN32 Gene

Variants for TSPAN32 Gene

Sequence variations from dbSNP and Humsavar for TSPAN32 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000061442 -- 2,309,549(+) GGACA(C/G)CCACG intron-variant, nc-transcript-variant, utr-variant-5-prime
rs1000126797 -- 2,313,864(+) AGGGG(G/T)TTCCA intron-variant
rs1000135988 -- 2,299,008(+) GTTGG(A/G)AGCAG intron-variant, upstream-variant-2KB
rs1000249125 -- 2,318,351(+) TGTGT(C/G)GGGTC downstream-variant-500B
rs1000271975 -- 2,298,835(+) ATGAA(A/G)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSPAN32 Gene

Variant ID Type Subtype PubMed ID
esv1338872 CNV deletion 17803354
esv2744003 CNV deletion 23290073
esv2744004 CNV deletion 23290073
esv2744005 CNV deletion 23290073
esv3625125 CNV gain 21293372
nsv467645 CNV gain 19166990
nsv469928 CNV loss 18288195
nsv553047 CNV gain 21841781
nsv553081 CNV loss 21841781
nsv553086 CNV loss 21841781
nsv951285 CNV deletion 24416366

Variation tolerance for TSPAN32 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN32 Gene

Disorders for TSPAN32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPAN32 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN32
genes like me logo Genes that share disorders with TSPAN32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN32 Gene

Publications for TSPAN32 Gene

  1. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PMID: 10950922) Nicholson R.H. … Ko M.S.H. (Genomics 2000) 2 3 4 22 64
  2. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PMID: 10072438) Lee M.P. … Feinberg A.P. (Hum. Mol. Genet. 1999) 2 3 4 22 64
  3. Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PMID: 11718897) Robb L. … Wright M.D. (Biochim. Biophys. Acta 2001) 3 4 22 64
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TSPAN32 Gene

Sources for TSPAN32 Gene

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