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TSPAN32 Gene

protein-coding   GIFtS: 50
GCID: GC11P002323

Tetraspanin 32

(Previous name: pan-hematopoietic expression)
(Previous symbols: TSSC6, PHEMX)
  See TSPAN32-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tetraspanin 321 2     Pan-Hematopoietic Expression Protein2
PHEMX1 2 3 5     tetraspanin-322
TSSC61 2 3 5     tspan-322
Protein Phemx2 3     Tumor-Suppressing STF CDNA 62
Pan-Hematopoietic Expression1     Tumor-Suppressing Subchromosomal Transferable Fragment CDNA 62
ART12     Tumor-Suppressing Subtransferable Candidate 62
PHMX2     Tspan-323

External Ids:    HGNC: 134101   Entrez Gene: 100772   Ensembl: ENSG000000642017   OMIM: 6038535   UniProtKB: Q96QS13   
ORGUL members:         

Export aliases for TSPAN32 gene to outside databases

Previous GC identifers: GC11P002280 GC11P002113


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPAN32 Gene:
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable
fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region.
Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma,
adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted
genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes
imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also
involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSPAN32 Gene:
TSPAN32 (tetraspanin 32) is a protein-coding gene. Diseases associated with TSPAN32 include adrenocortical carcinoma, and beckwith-wiedemann syndrome.

Gene Wiki entry for TSPAN32 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN32 gene promoter:
         Elk-1   RP58   GATA-3   NCX/Ncx   MyoD   CREB   GATA-6   deltaCREB   HOXA5   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSPAN32 promoter sequence
   Search Chromatin IP Primers for TSPAN32

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15

TSPAN32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN32 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002323:  view genomic region     (about GC identifiers)

Start:
2,323,227 bp from pter      End:
2,339,430 bp from pter
Size:
16,204 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1 (See protein sequence)
Recommended Name: Tetraspanin-32  
Size: 320 amino acids; 34631 Da
Developmental stage: Expressed from early embryogenesis through to adulthood
Secondary accessions: Q96KX4 Q9HC50 Q9HC51 Q9Y5U1
Alternative splicing: 5 isoforms:  Q96QS1-1   Q96QS1-2   Q96QS1-3   Q96QS1-4   Q96QS1-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TSPAN32: NX_Q96QS1

Explore proteomics data for TSPAN32 at MOPED


See TSPAN32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_620591.3  
ENSEMBL proteins: 
 ENSP00000405001   ENSP00000182290   ENSP00000395018   ENSP00000370513   ENSP00000343285  
 ENSP00000405205   ENSP00000370509  

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antibodies-online proteins for TSPAN32 (3 products) 

 
antibodies-online peptides for TSPAN32

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TSPAN: Tetraspanins

3 InterPro protein domains:
 IPR018499 Tetraspanin/Peripherin
 IPR000301 Tetraspanin
 IPR008952 Tetraspanin_EC2

Graphical View of Domain Structure for InterPro Entry Q96QS1

ProtoNet protein and cluster: Q96QS1

UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1
Similarity: Belongs to the tetraspanin (TM4SF) family


Find genes that share domains with TSPAN32           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with TSPAN32           About GenesLikeMe


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tspan32):
 hematopoietic system  immune system 

Find genes that share phenotypes with TSPAN32           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TSPAN32

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TSN32_HUMAN, Q96QS1: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
plasma membrane2
golgi apparatus1
nucleus1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--
GO:0009986cell surface IEA--
GO:0016021integral component of membrane ----
GO:0070442alphaIIb-beta3 integrin complex IEA--

Find genes that share ontologies with TSPAN32           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN32
Interactions:

    Search GeneGlobe Interaction Network for TSPAN32

Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007010cytoskeleton organization IEA--
GO:0007229integrin-mediated signaling pathway IEA--
GO:0007267cell-cell signaling TAS10950922
GO:0007596blood coagulation ----
GO:0007599hemostasis ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TSPAN32 (TSN32)

7 Novoseek inferred chemical compound relationships for TSPAN32 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ganglioside 44.3 4 15334254 (1), 12068006 (1), 15710618 (1), 19559406 (1)
tyrosine 31 6 10427099 (1), 12938224 (1), 12110679 (1), 19166707 (1) (see all 5)
lipid 27.3 9 15454569 (1), 15496196 (1), 16785325 (1), 19497983 (1) (see all 9)
phosphatidylinositol 23.4 2 12110679 (1), 11739647 (1)
cysteine 23.2 5 20171294 (2), 11907260 (1), 14556650 (1), 12575999 (1)
cholesterol 5.22 23 12938224 (5), 15184367 (2), 15454569 (1), 19497983 (1) (see all 5)
polysaccharide 0 1 12701754 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TSPAN32 gene (3 alternative transcripts): 
NM_139022.2  NM_005705.4  NM_139024.3  

Unigene Cluster for TSPAN32:

Tetraspanin 32
Hs.271954  [show with all ESTs]
Unigene Representative Sequence: AK298692
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000437313 ENST00000461200(uc001lvx.1 uc009ydk.1 uc010qxk.2 uc001lvy.1 uc009ydl.1 uc001lwb.1 uc001lwc.1 uc001lwd.1)
ENST00000182290 ENST00000446063 ENST00000493924 ENST00000484104 ENST00000479508
ENST00000498313 ENST00000483227 ENST00000381121 ENST00000493948 ENST00000339046
ENST00000451520(uc001lvz.1) ENST00000381117 ENST00000484523 ENST00000486011

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Additional mRNA sequence: 

AF176071.1 AK298692.1 AK307638.1 AK310116.1 AY039001.1 AY303780.1 BC016693.1 

11 DOTS entries:

DT.95168325  DT.111418  DT.95094062  DT.111419  DT.91648803  DT.97812022  DT.91656368  DT.120684722 
DT.95168321  DT.95168322  DT.40314344 

Selected AceView cDNA sequences (see all 49):

CR606621 NM_139022 AF176070 AW440888 AY039001 NM_139024 BX117724 BI906333 
AA701395 BF512909 AA694062 BM926073 BV196160 BC016693 BG506933 AF125569 
AY303780 AF176071 AK128812 BI909345 BI907377 N99620 AA777339 AA913945 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN32 (see all 12)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1:              -     -     -                 -           -                             -     -     -                                             
SP2:              -     -     -                 -           -                             -     -     -           -                                 
SP3:                                            -           -                 -           -     -     -                                             
SP4:                                            -           -                             -     -     -                                             
SP5:                                            -           -     -                       -     -     -                                             


ECgene alternative splicing isoforms for TSPAN32

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TSPAN32 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTGTAGGAC
TSPAN32 Expression
About this image


TSPAN32 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Liver (Hepatobiliary System)
         Hematopoietic Stem Cells Liver Bud
 
 Bone (Muscoskeletal System)
         Chondrocytes Zeugopod Epiphyseal End
 
 Cartilage (Muscoskeletal System)
         Chondrocytes Zeugopod Epiphyseal End
 
 Spleen (Hematopoietic System)
TSPAN32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TSPAN32 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.271954

UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1
Tissue specificity: Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic
tissues including peripheral blood leukocytes, thymus and spleen

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TSPAN32 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tspan321 , 5 tetraspanin 321, 5 76.02(n)1
64.03(a)1
  7 (88.09 cM)5
270271  NM_001128080.21  NP_001121552.11 
 1430050465 
chicken
(Gallus gallus)
Aves TSPAN321 tetraspanin 32 60.54(n)
46.58(a)
  395087  XM_004941440.1  XP_004941497.1 
lizard
(Anolis carolinensis)
Reptilia TSPAN326
tetraspanin 32
52(a)
1 ↔ 1
1(69690114-69698244)
tropical clawed frog
(Xenopus tropicalis)
Amphibia tspan321 tetraspanin 32 46.58(n)
32.22(a)
  100489691  XM_002938903.2  XP_002938949.2 


ENSEMBL Gene Tree for TSPAN32 (if available)
TreeFam Gene Tree for TSPAN32 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TSPAN32 gene
1 SIMAP similar gene for TSPAN32 using alignment to 5 protein entries:     TSN32_HUMAN (see all proteins):
PHEMX

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TSPAN32 (see all 419)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1833384091,2
--2325165(+) AGTCCC/TACCTC 1 -- int10--------
rs1176003571,2
C,F--2325192(+) GGGCCG/ATCTGA 1 -- int11Minor allele frequency- A:0.05NA 120
rs22342951,2
C,F--2325239(+) CCTCAC/TGGCCC 1 -- int11Minor allele frequency- T:0.03NA 120
rs2021894711,2
C--2325290(+) TCAGGA/GCCTGT 1 -- int10--------
rs2015309101,2
--2325347(+) TCTGCA/GGGGTT 2 A syn10--------
rs2006317811,2
--2325378(+) CTCTGA/GGAGCC 2 R G mis10--------
rs22342961,2
C,F,H--2325384(+) GAGCCG/ATGCTG 2 /M /V mis1 ese38Minor allele frequency- A:0.01NS EA CSA NA EU 4985
rs1996509871,2
--2325392(+) CTGAGC/TGCTGC 2 S syn10--------
rs2016344191,2
C--2325393(+) TGAGCA/GCTGCA 2 T A mis10--------
rs2006246621,2
C--2325414(+) GGGAGG/TCCCAG 2 A S mis10--------

HapMap Linkage Disequilibrium report for TSPAN32 (2323227 - 2339430 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TSPAN32 (see all 12):    About this table    
Variant IDTypeSubtypePubMed ID
esv2744004CNV Deletion23290073
esv2744005CNV Deletion23290073
esv2744003CNV Deletion23290073
esv1338872CNV Deletion17803354
nsv896801CNV Loss21882294
dgv999n71CNV Loss21882294
nsv469928CNV Loss18288195
nsv896806CNV Loss21882294
nsv896776CNV Loss21882294
nsv896804CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TSPAN32
DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN32

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603853    OMIM disorders: --

5 diseases for TSPAN32:    
About MalaCards
adrenocortical carcinoma    beckwith-wiedemann syndrome    alveolar echinococcosis    wilms tumor
malaria

1 disease from the University of Copenhagen DISEASES database for TSPAN32:
Beckwith-Wiedemann syndrome

Find genes that share disorders with TSPAN32           About GenesLikeMe

Selected Novoseek inferred disease relationships for TSPAN32 gene (see all 24)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis 52.3 50 16823699 (3), 19078974 (3), 19363832 (2), 16467180 (2) (see all 33)
hepatitis c 39.2 10 11226150 (2), 15449903 (1), 11134943 (1), 18836553 (1) (see all 9)
cancer 37.4 19 15205336 (1), 16823699 (1), 16944980 (1), 18395972 (1) (see all 16)
pathological processes 32.1 4 19251723 (1), 19703604 (1), 16404722 (1), 16467180 (1)
tumors 30.6 25 12579280 (2), 15205336 (1), 15533898 (1), 16823699 (1) (see all 22)
primary tumor 25.7 5 16467180 (2), 16404722 (1), 17582603 (1)
myeloma 23.9 2 18804164 (1), 16113057 (1)
colon cancer 23 4 16467180 (2), 16404722 (1)
immunodeficiency 16.7 4 16775336 (1), 18836553 (1), 17522207 (1), 19458002 (1)
schistosomiasis 11.1 2 9756983 (1), 17222846 (1)


Export disorders for TSPAN32 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TSPAN32 gene, integrated from 10 sources (see all 228) (see top 10):
(articles sorted by number of sources associating them with TSPAN32)
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  1. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PubMed id 10950922)1, 2, 3, 9 Nicholson R.H.... Ko M.S.H. (Genomics 2000)
  2. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PubMed id 10072438)1, 2, 3, 9 Lee M.P....Feinberg A.P. (Hum. Mol. Genet. 1999)
  3. Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PubMed id 11718897)1, 2, 9 Robb L....Wright M.D. (Biochim. Biophys. Acta 2001)
  4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PubMed id 23770605)1 Berndt S.I....Slager S.L. (Nat. Genet. 2013)
  7. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. (PubMed id 20709950)1 Gartlan K.H....Wright M.D. (J. Immunol. 2010)
  8. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (Blood 2007)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. (PubMed id 10915772)1 Paulsen M....Walter J. (Hum. Mol. Genet. 2000)
  11. A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. (PubMed id 9403053)1 Hu R.-J.... Feinberg A.P. (Genomics 1997)
  12. Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. (PubMed id 8469989)1 Koi M....Feinberg A.P. (Science 1993)
  13. A physical and functional link between cholesterol and tetraspanins. (PubMed id 12938224)9 Charrin S....Rubinstein E. (Eur. J. Immunol. 2003)
  14. Gastrointestinal tumors: metastasis and tetraspanins. (PubMed id 16823699)9 ZAPller M. (Z Gastroenterol 2006)
  15. Profiling of the tetraspanin web of human colon cancer cells. (PubMed id 16467180)9 Le Naour F....Rubinstein E. (amp 2006)
  16. Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. (PubMed id 11959120)9 Charrin S....Rubinstein E. (FEBS Lett. 2002)
  17. Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. (PubMed id 14556650)9 Kovalenko O.V.... Hemler M.E. (Biochem. J. 2004)
  18. Multiple levels of interactions within the tetraspanin web. (PubMed id 12705892)9 Charrin S....Rubinstein E. (Biochem. Biophys. Res. Commun. 2003)
  19. Fungi have three tetraspanin families with distinct functions. (PubMed id 18241352)9 Lambou K....Lebrun M.H. (BMC Genomics 2008)
  20. Tetraspanins connect several types of Ig proteins: IgM is a novel component of the tetraspanin web on B-lymphoid cells. (PubMed id 14730399)9 Le Naour F....Rubinstein E. (Cancer Immunol. Immunother. 2004)
  21. EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. (PubMed id 12708969)9 Charrin S.... Rubinstein E. (Biochem. J. 2003)
  22. Characterization of cDNAs encoding a new family of tetraspanins from schistosomes--the Sj25 family. (PubMed id 9756983)9 Fan J. and Brindley P.J. (Gene 1998)
  23. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. (PubMed id 18795891)9 Protty M.B.... Tomlinson M.G. (Biochem. J. 2009)
  24. Tetraspanins regulate cell-to-cell transmission of HIV-1. (PubMed id 19602278)9 Krementsov D.N....Thali M. (Retrovirology 2009)
  25. Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. (PubMed id 16404722)9 Andre M.... Le Naour F. (Proteomics 2006)
  26. Expression of tetraspanins in peripheral blood leukocytes: a comparison between normal and infectious conditions. (PubMed id 15304003)9 Tohami T....Lishner M. (Tissue Antigens 2004)
  27. Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation. (PubMed id 15454569)9 Delaguillaumie A....Conjeaud H. (J. Cell. Sci. 2004)
  28. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. (PubMed id 14570575)9 Hemler M.E. (Annu. Rev. Cell Dev. Biol. 2003)
  29. Analysis of the CD151-alpha3beta1 integrin and CD151-tetraspanin interactions by mutagenesis. (PubMed id 11479292)9 Berditchevski F....Jenner S.J. (J. Biol. Chem. 2001)
  30. Fungal pattern-recognition receptors and tetraspanins: partners on antigen-presenting cells. (PubMed id 20036798)9 Figdor C.G. and van Spriel A.B. (Trends Immunol. 2010)
  31. Tetraspanins and vascular functions. (PubMed id 19251723)9 Zhang F....Zhang X.A. (Cardiovasc. Res. 2009)
  32. Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells. (PubMed id 19458002)9 Weng J....Thali M. (J. Virol. 2009)
  33. Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web. (PubMed id 18710926)9 Espenel C....Milhiet P.E. (J. Cell Biol. 2008)
  34. Tetraspanin-Fc receptor interactions. (PubMed id 15763890)9 Moseley G.W. (Platelets 2005)
  35. Tetraspanin proteins as organisers of membrane microdomains and signalling complexes. (PubMed id 12681443)9 Yunta M. and Lazo P.A. (Cell. Signal. 2003)
  36. Complexes of tetraspanins with integrins: more than meets the eye. (PubMed id 11739647)9 Berditchevski F. (J. Cell. Sci. 2001)
  37. The tetraspanin superfamily: molecular facilitators. (PubMed id 9194523)9 Maecker H.T....Levy S. (FASEB J. 1997)
  38. Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections. (PubMed id 19894777)9 Hassuna N....Partridge L.J. (BioDrugs 2009)
  39. Evaluation of Echinococcus multilocularis tetraspanins as vaccine candidates against primary alveolar echinococcosis. (PubMed id 19782112)9 Dang Z....Sugimoto C. (Vaccine 2009)
  40. Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor. (PubMed id 18981120)9 Arduise C....Le Naour F. (J. Immunol. 2008)
  41. A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9. (PubMed id 17644758)9 Kovalenko O.V....Hemler M.E. (amp 2007)
  42. Tetraspanins as regulators of protein trafficking. (PubMed id 17181773)9 Berditchevski F. and Odintsova E. (Traffic 2007)
  43. Tetraspanin microdomains in immune cell signalling and malignant disease. (PubMed id 15496196)9 Wright M.D....van Spriel A.B. (Tissue Antigens 2004)
  44. Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling. (PubMed id 12110679)9 Berditchevski F....Gilbert E. (J. Biol. Chem. 2002)
  45. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. (PubMed id 11483611)9 Seigneuret M....Conjeaud H. (J. Biol. Chem. 2001)
  46. Tetraspanins. (PubMed id 11577978)9 Boucheix C. and Rubinstein E. (Cell. Mol. Life Sci. 2001)
  47. Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. (PubMed id 10427099)9 Berditchevski F. and Odintsova E. (J. Cell Biol. 1999)
  48. A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells. (PubMed id 20220101)9 Dunn C.D....Greenwald I. (Proc. Natl. Acad. Sci. U.S.A. 2010)
  49. Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets. (PubMed id 20078909)9 Stipp C.S. (Expert Rev Mol Med 2010)
  50. Intron sliding in tetraspanins. (PubMed id 19907697)9 Garcia-EspaA+a A. and DeSalle R. (amp 2009)
  51. Intron evolution: testing hypotheses of intron evolution using the phylogenomics of tetraspanins. (PubMed id 19262691)9 Garcia-EspaA+a A....Desalle R. (PLoS ONE 2009)
  52. In situ chemical cross-linking on living cells reveals CD9P-1 cis-oligomer at cell surface. (PubMed id 19703604)9 AndrAc M....Le Naour F. (J Proteomics 2009)
  53. Tetraspanins affect myeloma cell fate via Akt signaling and FoxO activation. (PubMed id 18804164)9 Lishner M....Drucker L. (Cell. Signal. 2008)
  54. Appearance of new tetraspanin genes during vertebrate evolution. (PubMed id 18291621)9 Garcia-EspaA+a A....Desalle R. (Genomics 2008)
  55. CDw78 defines MHC class II-peptide complexes that require Ii chain-dependent lysosomal trafficking, not localization to a specific tetraspanin membrane microdomain. (PubMed id 17015731)9 Poloso N.J....Roche P.A. (J. Immunol. 2006)
  56. Promoter hypermethylation of tetraspanin members contributes to their silencing in myeloma cell lines. (PubMed id 16113057)9 Drucker L....Lishner M. (Carcinogenesis 2006)
  57. Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments. (PubMed id 16449649)9 Shoham T....Levy S. (Mol. Cell. Biol. 2006)
  58. Different expression of adhesion molecules and tetraspanins of monocytes of patients with atopic eczema. (PubMed id 17073872)9 Jockers J.J. and Novak N. (Allergy 2006)
  59. The tetraspanin web modulates immune-signalling complexes. (PubMed id 15688041)9 Levy S. and Shoham T. (Nat. Rev. Immunol. 2005)
  60. Tetraspanin functions and associated microdomains. (PubMed id 16314869)9 Hemler M.E. (Nat. Rev. Mol. Cell Biol. 2005)
  61. The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. (PubMed id 15492270)9 Zhou B....Zhang X.A. (Cancer Res. 2004)
  62. Palmitoylation supports assembly and function of integrin-tetraspanin complexes. (PubMed id 15611341)9 Yang X....Hemler M.E. (J. Cell Biol. 2004)
  63. Expression of tetraspanin adaptor proteins below defined threshold values is associated with in vitro invasiveness of mammary carcinoma cells. (PubMed id 12579280)9 Sauer G....Deissler H. (Oncol. Rep. 2003)
  64. Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. (PubMed id 11907260)9 Yang X....Hemler M.E. (Mol. Biol. Cell 2002)
  65. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PubMed id 11278880)9 Charrin S.... Rubinstein E. (J. Biol. Chem. 2001)
  66. Tetraspanins expressed in the embryonic chick nervous system. (PubMed id 10561501)9 Perron J.C. and Bixby J.L. (FEBS Lett. 1999)
  67. Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy. (PubMed id 9531564)9 Claas C....ZAPller M. (J. Cell Biol. 1998)
  68. Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets. (PubMed id 19640571)9 Israels S.J. and McMillan-Ward E.M. (Thromb. Res. 2010)
  69. Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling. (PubMed id 20144992)9 Danglot L....Galli T. (J. Cell. Sci. 2010)
  70. Evolution of cysteine patterns in the large extracellular loop of tetraspanins from animals, fungi, plants and single-celled eukaryotes. (PubMed id 20171294)9 DeSalle R....Garcia-EspaA+a A. (Mol. Phylogenet. Evol. 2010)
  71. [Function of TM4SF-integrins complexes in regulating cancer metastasis]. (PubMed id 19363832)9 Zhu L.J. and Lai C. (Zhejiang Da Xue Xue Bao Yi Xue Ban 2009)
  72. Tetraspanins: push and pull in suppressing and promoting metastasis. (PubMed id 19078974)9 ZAPller M. (Nat. Rev. Cancer 2009)
  73. Tetraspanin CD151 regulates glycosylation of (alpha)3(beta)1 integrin. (PubMed id 18852263)9 Baldwin G....Berditchevski F. (J. Biol. Chem. 2008)
  74. Probing the interaction of tetraspanin CD151 with integrin alpha 3 beta 1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha 3 beta 1 complex. (PubMed id 18601653)9 Yamada M....Sekiguchi K. (Biochem. J. 2008)
  75. The tumor antigen EpCAM: tetraspanins and the tight junction protein claudin-7, new partners, new functions. (PubMed id 18508627)9 Le Naour F. and Zoller M. (Front. Biosci. 2008)
  76. Expression and function of transmembrane-4 superfamily (tetraspanin) proteins in osteoclasts: reciprocal roles of Tspan-5 and NET-6 during osteoclastogenesis. (PubMed id 17965585)9 Iwai K....Saeki Y. (Allergol Int 2007)
  77. Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. (PubMed id 16537545)9 Yang X.H....Hemler M.E. (J. Biol. Chem. 2006)
  78. Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells. (PubMed id 16552713)9 Crotta S....Wack A. (Eur. J. Immunol. 2006)
  79. Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion. (PubMed id 17015697)9 GordA^n-Alonso M....SA!nchez-Madrid F. (J. Immunol. 2006)
  80. Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. (PubMed id 15837731)9 Gesierich S....ZAPller M. (Clin. Cancer Res. 2005)
  81. Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation. (PubMed id 15931266)9 Barrena S....Lazo P.A. (Leukemia 2005)
  82. Association of major histocompatibility complex II with cholesterol- and sphingolipid-rich membranes precedes peptide loading. (PubMed id 15184367)9 Karacsonyi C....Lindner R. (J. Biol. Chem. 2004)
  83. Functional domains in tetraspanin proteins. (PubMed id 12575999)9 Stipp C.S....Hemler M.E. (Trends Biochem. Sci. 2003)
  84. Interspecies contamination of the KM3 cell line: implications for CD63 function in melanoma metastasis. (PubMed id 12740908)9 Moseley G.W....Monk P.N. (Int. J. Cancer 2003)
  85. Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer. (PubMed id 12569360)9 Funakoshi T....Kawase I. (Oncogene 2003)
  86. The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. (PubMed id 14530327)9 Shoham T....Levy S. (J. Immunol. 2003)
  87. CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets. (PubMed id 11204565)9 Israels S.J....McNicol A. (Thromb. Haemost. 2001)
  88. CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. (PubMed id 11226150)9 Kitadokoro K.... Bolognesi M. (EMBO J. 2001)
  89. Specific tetraspanin functions. (PubMed id 11756464)9 Hemler M.E. (J. Cell Biol. 2001)
  90. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. (PubMed id 11532191)9 Gonen T....Kistler J. (BMC Cell Biol. 2001)
  91. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells. (PubMed id 11157846)9 Engering A. and Pieters J. (Int. Immunol. 2001)
  92. Tetraspanins and intercellular interactions. (PubMed id 11498779)9 YA!nez-MA^ M....SA!nchez-Madrid F. (Microcirculation 2001)
  93. Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration. (PubMed id 10844555)9 PeA+as P.F....YA!A+ez-MA^ M. (J. Invest. Dermatol. 2000)
  94. Increased expression of the tetraspanins CD53 and CD63 on apoptotic human neutrophils. (PubMed id 10733097)9 Beinert T....Krombach F. (J. Leukoc. Biol. 2000)
  95. Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures. (PubMed id 11043545)9 GarcA-a-Frigola C....Soriano E. (Neuroreport 2000)
  96. Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis. (PubMed id 10447000)9 Testa J.E....Quigley J.P. (Cancer Res. 1999)
  97. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. (PubMed id 9597125)9 Levy S....Maecker H.T. (Annu. Rev. Immunol. 1998)
  98. The role of tetraspanins in the pathogenesis of infectious diseases. (PubMed id 19896556)9 van Spriel A.B. and Figdor C.G. (Microbes Infect. 2010)
  99. Tspan-1 is a tetraspanin preferentially expressed by mucinous and endometrioid subtypes of human ovarian carcinomas. (PubMed id 19017553)9 Scholz C.J....Deissler H. (Cancer Lett. 2009)
  100. Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling. (PubMed id 19755988)9 Zismanov V....Drucker L. (Br. J. Cancer 2009)
  101. The roles of tetraspanins in HIV-1 replication. (PubMed id 20012525)9 Thali M. (Curr. Top. Microbiol. Immunol. 2009)
  102. Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. (PubMed id 19838174)9 Wakabayashi T....De Strooper B. (Nat. Cell Biol. 2009)
  103. Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells. (PubMed id 19489128)9 Parthasarathy V....Partridge L.J. (Immunology 2009)
  104. The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. (PubMed id 18713730)9 Lineberry N....Fathman C.G. (J. Biol. Chem. 2008)
  105. Targeting of tetraspanin proteins--potential benefits and strategies. (PubMed id 18758472)9 Hemler M.E. (Nat Rev Drug Discov 2008)
  106. Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20. (PubMed id 18166196)9 Gonen T....Walz T. (J. Mol. Biol. 2008)
  107. The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells. (PubMed id 17407154)9 Abache T....Rubinstein E. (J. Cell. Biochem. 2007)
  108. Platelet tetraspanin complexes and their association with lipid rafts. (PubMed id 18000614)9 Israels S.J. and McMillan-Ward E.M. (Thromb. Haemost. 2007)
  109. Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. (PubMed id 17158226)9 Heikens M.J.... Tsai S. (Blood 2007)
  110. Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1. (PubMed id 16775336)9 Ho S.H....Monk P.N. (J. Virol. 2006)
  111. Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution. (PubMed id 16785325)9 Min G....Kong X.P. (J. Cell Biol. 2006)
  112. CD9 controls the formation of clusters that contain tetraspanins and the integrin alpha 6 beta 1, which are involved in human and mouse gamete fusion. (PubMed id 16418227)9 Ziyyat A....Wolf J.P. (J. Cell. Sci. 2006)
  113. Fungal Pls1 tetraspanins as key factors of penetration into host plants: a role in re-establishing polarized growth in the appressorium? (PubMed id 16499604)9 Veneault-Fourrey C....Lebrun M.H. (FEMS Microbiol. Lett. 2006)
  114. Predicted and measured disorder in peripherin/rds, a retinal tetraspanin. (PubMed id 16522184)9 Ritter L.M....Goldberg A.F. (Protein Pept. Lett. 2005)
  115. Role of tetraspanins CD9 and CD151 in primary melanocyte motility. (PubMed id 16297202)9 GarcA-a-LA^pez M.A....PeA+as P.F. (J. Invest. Dermatol. 2005)
  116. Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation. (PubMed id 15591117)9 Barreiro O....SA!nchez-Madrid F. (Blood 2005)
  117. Structural organization and interactions of transmembrane domains in tetraspanin proteins. (PubMed id 15985154)9 Kovalenko O.V....Hemler M.E. (BMC Struct. Biol. 2005)
  118. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association. (PubMed id 15004227)9 Little K.D.... Stipp C.S. (Mol. Biol. Cell 2004)
  119. CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. (PubMed id 15265795)9 Karamatic Crew V.... Anstee D.J. (Blood 2004)
  120. Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. (PubMed id 11805154)9 Waterhouse R....Dveksler G.S. (J. Exp. Med. 2002)
  121. Tetraspanin CD151 regulates growth of mammary epithelial cells in three-dimensional extracellular matrix: implication for mammary ductal carcinoma in situ. (PubMed id 20501858)9 Novitskaya V....Berditchevski F. (Cancer Res. 2010)
  122. Downregulation of CD9 protein expression is associated with aggressive behavior of oral squamous cell carcinoma. (PubMed id 20060356)9 Buim M.E....Soares F.A. (Oral Oncol. 2010)
  123. Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. (PubMed id 20124223)9 Park J.E....Sze S.K. (amp 2010)
  124. Tetraspanin CD81 is required for Listeria monocytogenes invasion. (PubMed id 19901060)9 Tham T.N....Pizarro-Cerda J. (Infect. Immun. 2010)
  125. CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas. (PubMed id 20004001)9 Luo R.F....Natkunam Y. (Hum. Pathol. 2010)
  126. Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility. (PubMed id 19874824)9 Hakomori S.I. (FEBS Lett. 2010)
  127. Expression and function of CD9 in melanoma cells. (PubMed id 19777564)9 Fan J....Niles R.M. (Mol. Carcinog. 2010)
  128. Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression. (PubMed id 20118909)9 Woegerbauer M....Erovic B.M. (Mod. Pathol. 2010)
  129. Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes. (PubMed id 19709882)9 YA!A+ez-MA^ M....SA!nchez-Madrid F. (Trends Cell Biol. 2009)
  130. Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells. (PubMed id 19559406)9 Park S.Y....Hakomori S.I. (Carbohydr. Res. 2009)
  131. KAI-1/CD82, the molecule and clinical implication in cancer and cancer metastasis. (PubMed id 19224455)9 Malik F.A....Jiang W.G. (Histol. Histopathol. 2009)
  132. Role of platelets in atherothrombosis. (PubMed id 19166707)9 Jennings L.K. (Am. J. Cardiol. 2009)
  133. Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo. (PubMed id 19107234)9 Kolesnikova T.V....Hemler M.E. (Neoplasia 2009)
  134. Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. (PubMed id 19587294)9 Xu D.... Hemler M.E. (FASEB J. 2009)
  135. Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation. (PubMed id 19574424)9 Liu B....Michalopoulos G.K. (Am. J. Pathol. 2009)
  136. Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts. (PubMed id 19509057)9 Johnson J.L....Stipp C.S. (J. Cell. Sci. 2009)
  137. Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC. (PubMed id 19089816)9 Sheng K.C....Wright M.D. (Eur. J. Immunol. 2009)
  138. CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts. (PubMed id 19497983)9 Xu C....Zhang X.A. (FASEB J. 2009)
  139. A novel therapeutic strategy with anti-CD9 antibody in gastric cancers. (PubMed id 19468669)9 Nakamoto T....Hayashi N. (J. Gastroenterol. 2009)
  140. Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum. (PubMed id 19508227)9 Scholz C.-J.... Deissler H. (Protein Pept. Lett. 2009)
  141. Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. (PubMed id 19211836)9 Lafleur M.A.... Hemler M.E. (Mol. Biol. Cell 2009)
  142. The role of membrane microdomains in transmembrane signaling through the epithelial glycoprotein Gp140/CDCP1. (PubMed id 18269919)9 Alvares S.M....Carter W.G. (Biochim. Biophys. Acta 2008)
  143. A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells. (PubMed id 18395972)9 Abe M....Shirasuna K. (Cancer Lett. 2008)
  144. CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages. (PubMed id 18321974)9 Ruiz-Mateos E....Marsh M. (J. Virol. 2008)
  145. Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs). (PubMed id 18836553)9 Spoden G....Florin L. (PLoS ONE 2008)
  146. The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells. (PubMed id 18247373)9 Murayama Y....Hayashi N. (J. Cell. Physiol. 2008)
  147. Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. (PubMed id 19073968)9 Chien C.W....Tsai S.J. (Clin. Cancer Res. 2008)
  148. Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma. (PubMed id 18466772)9 Mazzocca A....Carloni V. (Gastroenterology 2008)
  149. DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. (PubMed id 18508921)9 Sharma C....Hemler M.E. (Mol. Biol. Cell 2008)
  150. Tetraspanin in oncogenic epithelial-mesenchymal transition. (PubMed id 18357345)9 Muschel R.J. and Gal A. (J. Clin. Invest. 2008)
  151. Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production. (PubMed id 17182550)9 Meyer-Wentrup F....van Spriel A.B. (J. Immunol. 2007)
  152. Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells. (PubMed id 17668233)9 Kim Y.J....Jung J.S. (Pflugers Arch. 2007)
  153. Functional implications of tetraspanin proteins in cancer biology. (PubMed id 17727684)9 Lazo P.A. (Cancer Sci. 2007)
  154. The tetraspanin CD9 inhibits the proliferation and tumorigenicity of human colon carcinoma cells. (PubMed id 17582603)9 Ovalle S....CabaA+as C. (Int. J. Cancer 2007)
  155. Glycosylation status of the membrane protein CD9P-1. (PubMed id 17960739)9 Andre M.... Le Naour F. (Proteomics 2007)
  156. Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration. (PubMed id 17621632)9 Takahashi M....Shirasuna K. (Int. J. Cancer 2007)
  157. The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein. (PubMed id 17166843)9 Mazurov D....Derse D. (J. Biol. Chem. 2007)
  158. Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modifications. (PubMed id 17406028)9 Wang J.C....Chevrette M. (Clin. Cancer Res. 2007)
  159. Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. (PubMed id 17498801)9 Goenaga A.L....Poul M.A. (Mol. Immunol. 2007)
  160. Colocalisation of CD9 and mortalin in CD9-induced mitotic catastrophe in human prostate cancer cells. (PubMed id 17848953)9 Zvereff V....Chevrette M. (Br. J. Cancer 2007)
  161. Schistosome membrane proteins as vaccines. (PubMed id 17222846)9 Loukas A....Pearson M.S. (Int. J. Parasitol. 2007)
  162. Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains. (PubMed id 17522207)9 Jolly C. and Sattentau Q.J. (J. Virol. 2007)
  163. Molecular cloning and expression analysis of pig CD81. (PubMed id 17692929)9 Cho K.W....Chun T. (Vet. Immunol. Immunopathol. 2007)
  164. Overexpression of tetraspanins affects multiple myeloma cell survival and invasive potential. (PubMed id 17210782)9 Tohami T....Lishner M. (FASEB J. 2007)
  165. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. (PubMed id 16917503)9 Jung K.K....Kim H.R. (EMBO J. 2006)
  166. Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients. (PubMed id 16900214)9 De Bruyne E....Vanderkerken K. (Leukemia 2006)
  167. TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway. (PubMed id 17046995)9 Calzolari A....Testa U. (J. Cell. Sci. 2006)
  168. Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63. (PubMed id 16908530)9 Latysheva N....Berditchevski F. (Mol. Cell. Biol. 2006)
  169. Novel functions of TIMPs in cell signaling. (PubMed id 16680576)9 Chirco R....Kim H.R. (Cancer Metastasis Rev. 2006)
  170. Gangliosides play an important role in the organization of CD82-enriched microdomains. (PubMed id 16859490)9 Odintsova E....Berditchevski F. (Biochem. J. 2006)
  171. Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029. (PubMed id 16849554)9 Gesierich S....ZAPller M. (Cancer Res. 2006)
  172. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. (PubMed id 16690612)9 Sala-ValdAcs M....YA!A+ez-MA^ M. (J. Biol. Chem. 2006)
  173. Membrane microdomains and proteomics: lessons from tetraspanin microdomains and comparison with lipid rafts. (PubMed id 17109380)9 Le Naour F....Rubinstein E. (Proteomics 2006)
  174. KAI-1 expression in pediatric high-grade osteosarcoma. (PubMed id 16944980)9 Leavey P.J....Ashfaq R. (Pediatr. Dev. Pathol. 2006)
  175. Absence of CD9 enhances adhesion-dependent morphologic differentiation, survival, and matrix metalloproteinase-2 production in small cell lung cancer cells. (PubMed id 17018612)9 Saito Y....Kawase I. (Cancer Res. 2006)
  176. Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cells. (PubMed id 16490193)9 Chometon G....Aumailley M. (Exp. Cell Res. 2006)
  177. RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis. (PubMed id 16753027)9 Ishii M....Saeki Y. (J. Bone Miner. Res. 2006)
  178. KAI1 tetraspanin and metastasis suppressor. (PubMed id 15618009)9 Jackson P....Russell P.J. (amp 2005)
  179. Immunophenotypic analysis of human articular chondrocytes: changes in surface markers associated with cell expansion in monolayer culture. (PubMed id 15389573)9 Diaz-Romero J....Mainil-Varlet P. (J. Cell. Physiol. 2005)
  180. Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells. (PubMed id 15611113)9 Mazzocca A....Pinzani M. (J. Biol. Chem. 2005)
  181. Activation of naA^ve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders. (PubMed id 16339892)9 Rosa D....Abrignani S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
  182. Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion. (PubMed id 15557282)9 He B....Zhang X.A. (J. Biol. Chem. 2005)
  183. [Inhibition of the motility of melanoma cells using interference RNA against CD9]. (PubMed id 16476329)9 PeA+as P.F....Barreiro del RA-o O. (Actas Dermosifiliogr 2005)
  184. Potentiation of the ligand-binding activity of integrin alpha3beta1 via association with tetraspanin CD151. (PubMed id 15677332)9 Nishiuchi R....Sekiguchi K. (Proc. Natl. Acad. Sci. U.S.A. 2005)
  185. Dendritic cell-derived exosomes in cancer immunotherapy: exploiting nature's antigen delivery pathway. (PubMed id 16001959)9 Delcayre A....Le Pecq J.B. (Expert Rev Anticancer Ther 2005)
  186. Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor. (PubMed id 15710618)9 Toledo M.S....Hakomori S. (J. Biol. Chem. 2005)
  187. Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of beta1 integrin subsets. (PubMed id 15805258)9 Furuya M....Ishikura H. (Cancer Res. 2005)
  188. Complex formation of CD23/surface immunoglobulin and CD23/CD81/MHC class II on an EBV-transformed human B cell line and inferable role of tetraspanin. (PubMed id 15215629)9 Kijimoto-Ochiai S....Araki Y. (Microbiol. Immunol. 2004)
  189. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. (PubMed id 15205336)9 Lee J.H....Kim K.K. (Cancer Res. 2004)
  190. B cell signaling is regulated by induced palmitoylation of CD81. (PubMed id 15161911)9 Cherukuri A....Pierce S.K. (J. Biol. Chem. 2004)
  191. Role of beta(1)-integrins and their associated tetraspanin molecules in fibronectin-enhanced megakaryopoiesis. (PubMed id 15512913)9 Han P....Story C. (Cytotherapy 2004)
  192. Immunohistochemical distribution of CD9 in parotid gland tumors. (PubMed id 15041054)9 Sakamoto K....Nakashima T. (Auris Nasus Larynx 2004)
  193. Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling. (PubMed id 15334254)9 Hakomori S. (An. Acad. Bras. Cienc. 2004)
  194. CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner. (PubMed id 14966136)9 Clark K.L....Todd S.C. (J. Biol. Chem. 2004)
  195. [Structural biology of human CD81, a receptor for hepatitis C virus]. (PubMed id 15449903)9 Kitadokoro K. (Uirusu 2004)
  196. A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. (PubMed id 14963491)9 Xu H....Montell C. (EMBO J. 2004)
  197. CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: a new prognostic indicator? (PubMed id 15533898)9 Ang J....Frauman A.G. (amp 2004)
  198. Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. (PubMed id 14576349)9 Odintsova E....Berditchevski F. (J. Cell. Sci. 2003)
  199. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)9 Zhang X.A.... Liu L. (Cancer Res. 2003)
  200. Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation. (PubMed id 12597781)9 Maecker H.T. (BMC Immunol. 2003)
  201. Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophages. (PubMed id 12610138)9 von Lindern J.J....O'Brien W.A. (J. Virol. 2003)
  202. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. (PubMed id 14568979)9 Koopman L.A....Strominger J.L. (J. Exp. Med. 2003)
  203. Galectin-3, an endogenous lectin, as a tool for monitoring cell differentiation in head and neck carcinomas with implications for lectin-glycan functionality. (PubMed id 12701754)9 Betka J....Gabius H.J. (Acta Otolaryngol. 2003)
  204. Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration. (PubMed id 12738793)9 Zhang X.A....Liu L. (J. Biol. Chem. 2003)
  205. The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. (PubMed id 14660791)9 Duffield A....Caplan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  206. Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. (PubMed id 12595239)9 Murdoch J.N....Copp A.J. (Mol. Cell. Neurosci. 2003)
  207. [CD81: a tetraspanin implicated in Plasmodium infection]. (PubMed id 12836611)9 Silvie O....Mazier D. (Med Sci (Paris) 2003)
  208. Distinctive signaling pathways through CD82 and beta1 integrins in human T cells. (PubMed id 11981820)9 Iwata S....Morimoto C. (Eur. J. Immunol. 2002)
  209. Cooperation between heparin-binding EGF-like growth factor and interleukin-6 in promoting the growth of human myeloma cells. (PubMed id 11971193)9 Wang Y.D....Klein B. (Oncogene 2002)
  210. Tetraspanin CD9 is a &quot;proteolipid,&quot; and its interaction with alpha 3 integrin in microdomain is promoted by GM3 ganglioside, leading to inhibition of laminin-5-dependent cell motility. (PubMed id 12068006)9 Kawakami Y....Hakomori S. (J. Biol. Chem. 2002)
  211. Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes. (PubMed id 11839793)9 Delaguillaumie A....Conjeaud H. (J. Cell. Sci. 2002)
  212. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. (PubMed id 12175627)9 Mazzocca A....Pinzani M. (J. Hepatol. 2002)
  213. Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo. (PubMed id 11884516)9 Sterk L.M....Sonnenberg A. (J. Cell. Sci. 2002)
  214. Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4. (PubMed id 11782983)9 Hedera P....Fink J.K. (Ann. Neurol. 2002)
  215. Malignant effusions and immunogenic tumour-derived exosomes. (PubMed id 12147373)9 Andre F....Zitvogel L. (Lancet 2002)
  216. Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. (PubMed id 11325968)9 Zhang X.A....Hemler M.E. (J. Biol. Chem. 2001)
  217. Crystallization and preliminary crystallographic studies on the large extracellular domain of human CD81, a tetraspanin receptor for hepatitis C virus. (PubMed id 11134943)9 Kitadokoro K....Bolognesi M. (Acta Crystallogr. D Biol. Crystallogr. 2001)
  218. Overexpression of tetraspanin CO-029 in hepatocellular carcinoma. (PubMed id 11690710)9 Kanetaka K....Hirohashi S. (J. Hepatol. 2001)
  219. Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene. (PubMed id 11181065)9 Whittock N.V. and McLean W.H.I. (Biochem. Biophys. Res. Commun. 2001)
  220. [A crucial role of tetraspanin, CD9 in fertilization]. (PubMed id 10897685)9 Miyado K....Kobayashi K. (Tanpakushitsu Kakusan Koso 2000)
  221. Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. (PubMed id 10985391)9 Odintsova E....Berditchevski F. (Curr. Biol. 2000)
  222. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. (PubMed id 10655063)9 Zemni R.... Chelly J. (Nat. Genet. 2000)
  223. Interaction of CD82 tetraspanin proteins with HTLV-1 envelope glycoproteins inhibits cell-to-cell fusion and virus transmission. (PubMed id 11040136)9 Pique C....DokhAclar M.C. (Virology 2000)
  224. Domain analysis of the tetraspanins: studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding. (PubMed id 11235900)9 Ryu F....Mekada E. (Cell Struct. Funct. 2000)
  225. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. (PubMed id 10400713)9 Flint M....McKeating J.A. (J. Virol. 1999)
  226. Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization. (PubMed id 9812906)9 Scherberich A....Beretz A. (Arterioscler. Thromb. Vasc. Biol. 1998)
  227. Binding of hepatitis C virus to CD81. (PubMed id 9794763)9 Pileri P....Abrignani S. (Science 1998)

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Entrez Gene: 10077 HGNC: 13410 AceView: PHEMX Ensembl:ENSG00000064201 euGenes: HUgn10077
ECgene: TSPAN32 H-InvDB: TSPAN32

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PharmGKB entry for TSPAN32 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TSPAN32 Genetics and Cytogenetics in Oncology and Haematology

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