Aliases for TSPAN32 Gene
Aliases for TSPAN32 Gene
External Ids for TSPAN32 Gene
- HGNC: 13410
- Entrez Gene: 10077
- Ensembl: ENSG00000064201
- OMIM: 603853
- UniProtKB: Q96QS1
Previous HGNC Symbols for TSPAN32 Gene
- TSSC6
- PHEMX
Previous GeneCards Identifiers for TSPAN32 Gene
- GC11P002280
- GC11P002113
- GC11P002323
Summaries for TSPAN32 Gene
-
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TSPAN32 Gene
TSPAN32 (Tetraspanin 32) is a Protein Coding gene. Diseases associated with TSPAN32 include Beckwith-Wiedemann Syndrome.
Additional gene information for TSPAN32 Gene
- Monarch Initiative
- Search for TSPAN32 at DataMed
- Search for TSPAN32 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN32 Gene
Genomics for TSPAN32 Gene
GeneHancer (GH) Regulatory Elements for TSPAN32 Gene
Regulatory Element Products
Genomic Locations for TSPAN32 Gene
- chr11:2,301,997-2,318,201
- (GRCh38/hg38)
- Size:
- 16,205 bases
- Orientation:
- Plus strand
- chr11:2,323,227-2,339,430
- (GRCh37/hg19)
Genomic View for TSPAN32 Gene
- Cytogenetic band:
-
- 11p15.5 by Ensembl
- 11p15.5 by Entrez Gene
- 11p15.5 by HGNC


RefSeq DNA sequence for TSPAN32 Gene
Proteins for TSPAN32 Gene
-
Protein details for TSPAN32 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96QS1-TSN32_HUMAN
- Recommended name:
- Tetraspanin-32
- Protein Accession:
- Q96QS1
- Q96KX4
- Q9HC50
- Q9HC51
- Q9Y5U1
Protein attributes for TSPAN32 Gene
- Size:
- 320 amino acids
- Molecular mass:
- 34631 Da
- Quaternary structure:
- No Data Available
Protein Expression for TSPAN32 Gene
Post-translational modifications for TSPAN32 Gene
Other Protein References for TSPAN32 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TSPAN32
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- GeneTex TSPAN32 antibody for TSPAN32
-
Santa Cruz Biotechnology (SCBT) Antibodies for TSPAN32
Protein Products
-
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-
Quality Products:
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-
Abcam proteins for TSPAN32
Assay Products
No data available for DME Specific Peptides for TSPAN32 Gene
Domains & Families for TSPAN32 Gene
Gene Families for TSPAN32 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for TSPAN32 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TSPAN32 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96QS1- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for TSPAN32 Gene
Phenotypes From GWAS Catalog for TSPAN32 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
Phenotypes for TSPAN32 Gene
- MGI mutant phenotypes for TSPAN32:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TSPAN32:
Animal Model Products
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-
-
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-
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-
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Clone Products
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- XM_011519818.1
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN32 Gene
Localization for TSPAN32 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSPAN32 Gene
- Membrane; Multi-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
GO:0005887 | integral component of plasma membrane | IBA | -- |
GO:0009986 | cell surface | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPAN32 Gene
Pathways & Interactions for TSPAN32 Gene
Interacting Proteins for TSPAN32 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007010 | cytoskeleton organization | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
GO:0007229 | integrin-mediated signaling pathway | IEA | -- |
GO:0007267 | cell-cell signaling | TAS | 10950922 |
GO:0007596 | blood coagulation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TSPAN32 Gene
Transcripts for TSPAN32 Gene
mRNA/cDNA for TSPAN32 Gene
- (19) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (49) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TSPAN32
- genomics-online: gRNA clones - Search results for 96 available TSPAN32 gene related products
- Overview of 96 available TSPAN32 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN32
- GenScript: Design CRISPR guide RNA sequences for TSPAN32
miRNA Products
- Search ViGene Biosciences for TSPAN32
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for TSPAN32
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- genomics-online: shRNA clones - Search results for 96 available TSPAN32 gene related products
- Overview of 96 available TSPAN32 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for TSPAN32 in any vector
- XM_011519818.1
- XM_011519815.1
- NM_139022.2
- XM_011519812.1
- XM_011519827.1
- XM_011519810.1
- XM_011519824.1
- XM_011519822.1
- XM_011519819.1
- XM_011519816.1
- XM_011519813.1
- XM_011519828.1
- XM_011519811.1
- XM_011519825.1
- XM_005252720.3
- XM_011519820.1
- XM_011519817.1
- XM_011519814.1
- XM_011519829.1
- XM_005252719.3
- XM_011519826.1
- XM_011519809.1
- XM_011519823.1
- XM_011519821.1
- Sino Biological Human cDNA Clone for TSPAN32
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TSPAN32
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TSPAN32
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TSPAN32
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TSPAN32 (TSPAN32/TSSC6)
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP12: | - | - |
Expression for TSPAN32 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Liver Bud
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TSPAN32 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN32 Gene
NURSA nuclear receptor signaling pathways regulating expression of TSPAN32 Gene:
TSPAN32SOURCE GeneReport for Unigene cluster for TSPAN32 Gene:
Hs.271954mRNA Expression by UniProt/SwissProt for TSPAN32 Gene:
Q96QS1-TSN32_HUMANEvidence on tissue expression from TISSUES for TSPAN32 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for TSPAN32
-
OriGene qPCR primer pairs for TSPAN32
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No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN32 Gene
Orthologs for TSPAN32 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TSPAN32 33 |
|
||
dog (Canis familiaris) |
Mammalia | TSPAN32 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Phemx 33 |
|
||
mouse (Mus musculus) |
Mammalia | Tspan32 33 16 34 |
|
||
cow (Bos Taurus) |
Mammalia | TSPAN32 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TSPAN32 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TSPAN32 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TSPAN32 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tspan32 33 |
|
- Species where no ortholog for TSPAN32 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TSPAN32 Gene
(1) SIMAP similar genes for TSPAN32 Gene using alignment to 5 proteins:
No data available for Paralogs for TSPAN32 Gene
Variants for TSPAN32 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000061442 | -- | 2,309,549(+) | G/C | 5_prime_UTR_variant, intron_variant, non_coding_transcript_variant | |
rs1000126797 | -- | 2,313,864(+) | G/T | intron_variant | |
rs1000135988 | -- | 2,299,008(+) | G/A | upstream_transcript_variant | |
rs1000249125 | -- | 2,318,351(+) | G/C | downstream_transcript_variant | |
rs1000271975 | -- | 2,298,835(+) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1338872 | CNV | deletion | 17803354 |
esv2744003 | CNV | deletion | 23290073 |
esv2744004 | CNV | deletion | 23290073 |
esv2744005 | CNV | deletion | 23290073 |
esv3625125 | CNV | gain | 21293372 |
nsv467645 | CNV | gain | 19166990 |
nsv469928 | CNV | loss | 18288195 |
nsv553047 | CNV | gain | 21841781 |
nsv553081 | CNV | loss | 21841781 |
nsv553086 | CNV | loss | 21841781 |
nsv951285 | CNV | deletion | 24416366 |
Additional Variant Information for TSPAN32 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TSPAN32
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN32 Gene
Disorders for TSPAN32 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
beckwith-wiedemann syndrome |
|
|
Additional Disease Information for TSPAN32
No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN32 Gene
Publications for TSPAN32 Gene
- Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PMID: 10950922) Nicholson RH … Ko MS (Genomics 2000) 2 3 4 22 58
- Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PMID: 10072438) Lee MP … Feinberg AP (Human molecular genetics 1999) 2 3 4 22 58
- Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PMID: 11718897) Robb L … Wright MD (Biochimica et biophysica acta 2001) 3 4 22 58
- An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for TSPAN32 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 59 available TSPAN32 Antibodies ranked by validation data
- Compare Top TSPAN32 Antibodies
- antibodies-online: Search results for available TSPAN32 related products ranked by validation data
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- Search Santa Cruz Biotechnology (SCBT) for TSPAN32 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN32
- Horizon Cell Lines for TSPAN32
- genomics-online: cdna clones - Search results for 96 available TSPAN32 gene related products
- Overview of 96 available TSPAN32 gene related products
- orf clones - Search results for 96 available TSPAN32 gene related products
- Overview of 96 available TSPAN32 gene related products
- genomics-online: gRNA clones - Search results for 96 available TSPAN32 gene related products
- Overview of 96 available TSPAN32 gene related products
- genomics-online: primer clones - Search results for 96 available TSPAN32 gene related products
- Overview of 96 available TSPAN32 gene related products
- genomics-online: shRNA clones - Search results for 96 available TSPAN32 gene related products
- Overview of 96 available TSPAN32 gene related products
Sources for TSPAN32 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew