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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPAN32 Gene

protein-coding   GIFtS: 49
GCID: GC11P002323

Tetraspanin 32

(Previous name: pan-hematopoietic expression)
(Previous symbols: TSSC6, PHEMX)
Microbiology & Infectious Diseases Congress
  34 related diseases
at
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Aliases
for TSPAN32 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Tetraspanin 321 2     Pan-Hematopoietic Expression Protein2
PHEMX1 2 3 5     tetraspanin-322
TSSC61 2 3 5     tspan-322
Protein Phemx2 3     Tumor-Suppressing STF CDNA 62
Pan-Hematopoietic Expression1     Tumor-Suppressing Subchromosomal Transferable Fragment CDNA 62
ART12     Tumor-Suppressing Subtransferable Candidate 62
PHMX2     Tspan-323

External Ids:    HGNC: 134101   Entrez Gene: 100772   Ensembl: ENSG000000642017   OMIM: 6038535   UniProtKB: Q96QS13   

Export aliases for TSPAN32 gene to outside databases

Previous GC identifers: GC11P002280 GC11P002113


Summaries
for TSPAN32 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TSPAN32 Gene:
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable
fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region.
Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma,
adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted
genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes
imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also
involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSPAN32 Gene: 
TSPAN32 (tetraspanin 32) is a protein-coding gene. Diseases associated with TSPAN32 include adrenocortical carcinoma, and mental retardation epilepsy. GO annotations related to this gene include molecular_function.

Gene Wiki entry for TSPAN32 Gene


Genomic Views
for TSPAN32 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPAN32 gene promoter:
         Elk-1   RP58   GATA-3   NCX/Ncx   MyoD   CREB   GATA-6   deltaCREB   HOXA5   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSPAN32 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPAN32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15

TSPAN32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN32 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002323:  view genomic region     (about GC identifiers)

Start:
 2,323,227 bp from pter      End:
 2,339,430 bp from pter
Size:
 16,204 bases      Orientation:
 plus strand

Proteins
for TSPAN32 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1 (See protein sequence)
Recommended Name: Tetraspanin-32  
Size: 320 amino acids; 34631 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Developmental stage: Expressed from early embryogenesis through to adulthood
Secondary accessions: Q96KX4 Q9HC50 Q9HC51 Q9Y5U1
Alternative splicing: 5 isoforms:  Q96QS1-1   Q96QS1-2   Q96QS1-3   Q96QS1-4   Q96QS1-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TSPAN32: NX_Q96QS1

Explore proteomics data for TSPAN32 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96QS1

    • TSPAN32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSPAN32 Protein Expression
    REFSEQ proteins: NP_620591.3  
    ENSEMBL proteins: 
     ENSP00000405001   ENSP00000182290   ENSP00000395018   ENSP00000370513   ENSP00000343285  
     ENSP00000405205   ENSP00000370509  

    Human Recombinant Protein Products for TSPAN32: 
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    Novus Biologicals TSPAN32 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSPAN32 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane NAS--
    GO:0070442alphaIIb-beta3 integrin complex IEA--

    TSPAN32 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TSPAN32 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    TSPAN: Tetraspanins

    3 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2

    Graphical View of Domain Structure for InterPro Entry Q96QS1

    ProtoNet protein and cluster: Q96QS1

    UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1
    Similarity: Belongs to the tetraspanin (TM4SF) family


    TSPAN32 for domains           About GeneDecksing


    Function
    for TSPAN32 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TSPAN32 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tspan32):
     cellular  hematopoietic system  immune system 

    TSPAN32 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPAN32 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPAN32

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPAN32 
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for TSPAN32 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN32

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007267cell-cell signaling TAS10950922
    GO:0007596blood coagulation ----
    GO:0007599hemostasis ----

    TSPAN32 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TSPAN32 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TSPAN32 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSPAN32 (TSN32)

    7 Novoseek inferred chemical compound relationships for TSPAN32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ganglioside 44.3 4 15334254 (1), 12068006 (1), 15710618 (1), 19559406 (1)
    tyrosine 31 6 10427099 (1), 12938224 (1), 12110679 (1), 19166707 (1) (see all 5)
    lipid 27.3 9 15454569 (1), 15496196 (1), 16785325 (1), 19497983 (1) (see all 9)
    phosphatidylinositol 23.4 2 12110679 (1), 11739647 (1)
    cysteine 23.2 5 20171294 (2), 11907260 (1), 14556650 (1), 12575999 (1)
    cholesterol 5.22 23 12938224 (5), 15184367 (2), 15454569 (1), 19497983 (1) (see all 5)
    polysaccharide 0 1 12701754 (1)

    Search CenterWatch for drugs/clinical trials and news about TSPAN32 / TSN32

    Transcripts
    for TSPAN32 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSPAN32 gene (3 alternative transcripts): 
    NM_139022.2  NM_005705.4  NM_139024.3  

    Unigene Cluster for TSPAN32:

    Tetraspanin 32
    Hs.271954  [show with all ESTs]
    Unigene Representative Sequence: AK298692
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437313 ENST00000461200(uc001lvx.1 uc009ydk.1 uc010qxk.2 uc001lvy.1 uc009ydl.1 uc001lwb.1 uc001lwc.1 uc001lwd.1)
    ENST00000182290 ENST00000446063 ENST00000493924 ENST00000484104 ENST00000479508
    ENST00000498313 ENST00000483227 ENST00000381121 ENST00000493948 ENST00000339046
    ENST00000451520(uc001lvz.1) ENST00000381117 ENST00000484523 ENST00000486011

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TSPAN32
    SwitchGear 3'UTR luciferase reporter plasmid: TSPAN32 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN32
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN32

    Additional mRNA sequence: 

    AF176071.1 AK298692.1 AK307638.1 AK310116.1 AY039001.1 AY303780.1 BC016693.1 

    11 DOTS entries:

    DT.95168325  DT.111418  DT.95094062  DT.111419  DT.91648803  DT.97812022  DT.91656368  DT.120684722 
    DT.95168321  DT.95168322  DT.40314344 

    24/49 AceView cDNA sequences (see all 49):

    AF176070 NM_139022 AA701395 CR606621 AY039001 AW440888 BI906333 NM_139024 
    BX117724 N99620 BI909447 AA694062 AA777339 BE243068 AF176071 BG506933 
    BI909345 AY303780 NM_005705 AA913945 AK128812 BI907377 BC016693 BV196160 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN32 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:              -     -     -                 -           -                             -     -     -                                             
    SP2:              -     -     -                 -           -                             -     -     -           -                                 
    SP3:                                            -           -                 -           -     -     -                                             
    SP4:                                            -           -                             -     -     -                                             
    SP5:                                            -           -     -                       -     -     -                                             


    ECgene alternative splicing isoforms for TSPAN32

    Expression
    for TSPAN32 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSPAN32 expression in normal human tissues (normalized intensities)      TSPAN32 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTAGGAC
    TSPAN32 Expression
    About this image


    TSPAN32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             cd8+ t cell   
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End

    See TSPAN32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSPAN32

    SOURCE GeneReport for Unigene cluster: Hs.271954

    UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1
    Tissue specificity: Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic
    tissues including peripheral blood leukocytes, thymus and spleen

        SABiosciences Custom PCR Arrays for TSPAN32
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    In Situ
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    Orthologs
    for TSPAN32 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TSPAN32 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tspan321 , 5 tetraspanin 321, 5 76.02(n)1
    64.03(a)1    		   7 (88.09 cM)5
    270271  NM_001128080.21  NP_001121552.11 
     1430050465 
    chicken
    (Gallus gallus)    		 Aves TSPAN321 tetraspanin 32 59.82(n)
    47.49(a)    		   395087  XM_421025.2  XP_421025.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TSPAN326
    		 Uncharacterized protein
    		 52(a)
    		 1 ↔ 1
    		 1(69690114-69698244)


    ENSEMBL Gene Tree for TSPAN32 (if available)
    TreeFam Gene Tree for TSPAN32 (if available)

    Paralogs
    for TSPAN32 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSPAN32 gene
    1 SIMAP similar gene for TSPAN32 using alignment to 5 protein entries:     TSN32_HUMAN (see all proteins):
    PHEMX

    TSPAN32 for paralogs           About GeneDecksing



    Genomic Variants
    for TSPAN32 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/419 SNPs in TSPAN32 are shown (see all 419)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1833384091,2
    		--2325165(+) AGTCCC/TACCTC 1 -- int10--------
    rs1176003571,2
    		C,F--2325192(+) GGGCCG/ATCTGA 1 -- int11Minor allele frequency- A:0.05NA 120
    rs22342951,2
    		C,F--2325239(+) CCTCAC/TGGCCC 1 -- int11Minor allele frequency- T:0.03NA 120
    rs2021894711,2
    		C--2325290(+) TCAGGA/GCCTGT 1 -- int10--------
    rs2015309101,2
    		--2325347(+) TCTGCA/GGGGTT 2 A syn10--------
    rs2006317811,2
    		--2325378(+) CTCTGA/GGAGCC 2 R G mis10--------
    rs22342961,2
    		C,F,H--2325384(+) GAGCCG/ATGCTG 2 /M /V mis1 ese38Minor allele frequency- A:0.01NS EA CSA NA EU 4985
    rs1996509871,2
    		--2325392(+) CTGAGC/TGCTGC 2 S syn10--------
    rs2016344191,2
    		C--2325393(+) TGAGCA/GCTGCA 2 T A mis10--------
    rs2006246621,2
    		C--2325414(+) GGGAGG/TCCCAG 2 A S mis10--------

    HapMap Linkage Disequilibrium report for TSPAN32 (2323227 - 2339430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for TSPAN32 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744004CNV Deletion23290073
    esv2744005CNV Deletion23290073
    esv2744003CNV Deletion23290073
    esv1338872CNV Deletion17803354
    nsv896801CNV Loss21882294
    dgv999n71CNV Loss21882294
    nsv469928CNV Loss18288195
    nsv896806CNV Loss21882294
    nsv896776CNV Loss21882294
    nsv896804CNV Loss21882294

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    Disorders / Diseases
    for TSPAN32 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 603853    OMIM disorders: --

    20/34 diseases for TSPAN32 (see all 34):    About MalaCards
    adrenocortical carcinoma    mental retardation epilepsy    beckwith-wiedemann syndrome    alveolar echinococcosis
    echinococcosis    disseminated intravascular coagulation    epilepsy syndrome    schistosomiasis
    merkel cell carcinoma    wilms tumor    rhabdomyosarcoma    diphtheria
    myeloma    retinal degeneration    eczema    breast cancer
    hepatitis c    multiple myeloma    oral squamous cell carcinoma    lung cancer

    1 disease from the University of Copenhagen DISEASES database for TSPAN32:
    Beckwith-Wiedemann syndrome

    TSPAN32 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/24 Novoseek inferred disease relationships for TSPAN32 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 52.3 50 16823699 (3), 19078974 (3), 19363832 (2), 16467180 (2) (see all 33)
    hepatitis c 39.2 10 11226150 (2), 15449903 (1), 11134943 (1), 18836553 (1) (see all 9)
    cancer 37.4 19 15205336 (1), 16823699 (1), 16944980 (1), 18395972 (1) (see all 16)
    pathological processes 32.1 4 19251723 (1), 19703604 (1), 16404722 (1), 16467180 (1)
    tumors 30.6 25 12579280 (2), 15205336 (1), 15533898 (1), 16823699 (1) (see all 22)
    primary tumor 25.7 5 16467180 (2), 16404722 (1), 17582603 (1)
    myeloma 23.9 2 18804164 (1), 16113057 (1)
    colon cancer 23 4 16467180 (2), 16404722 (1)
    immunodeficiency 16.7 4 16775336 (1), 18836553 (1), 17522207 (1), 19458002 (1)
    schistosomiasis 11.1 2 9756983 (1), 17222846 (1)


    Export disorders for TSPAN32 gene to outside databases

    Publications
    for TSPAN32 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSPAN32 gene, integrated from 9 sources (see all 227):
    (articles sorted by number of sources associating them with TSPAN32)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PubMed id 10950922)1, 2, 3, 9 Nicholson R.H.... Ko M.S.H. (2000)
    2. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PubMed id 10072438)1, 2, 3, 9 Lee M.P....Feinberg A.P. (1999)
    3. Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PubMed id 11718897)1, 2, 9 Robb L....Wright M.D. (2001)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A complementary role for the tetraspanins CD37 and Ts sc6 in cellular immunity. (PubMed id 20709950)1 Gartlan K.H....Wright M.D. (2010)
    7. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. (PubMed id 10915772)1 Paulsen M....Walter J. (2000)
    10. A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. (PubMed id 9403053)1 Hu R.-J.... Feinberg A.P. (1997)

    External Searches for TSPAN32 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TSPAN32 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10077 HGNC: 13410 AceView: PHEMX Ensembl:ENSG00000064201 euGenes: HUgn10077
    ECgene: TSPAN32 H-InvDB: TSPAN32

    Other Databases showing TSPAN32 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TSPAN32 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSPAN32 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPAN32 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TSPAN32 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TSPAN32 gene:
    Search GeneIP for patents involving TSPAN32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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