TSPAN32 Gene

Aliases
for TSPAN32 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC11P002280 GC11P002113

Summaries
for TSPAN32 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TSPAN32 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000011.9  NT_009237.19  NC_018922.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSPAN32 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN32

TSPAN32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002323:  view genomic region     (about GC identifiers)

Proteins
for TSPAN32 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TSPAN32: NX_Q96QS1

Explore proteomics data for TSPAN32 at MOPED


See TSPAN32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

TSPAN32 Human Recombinant Protein Products:

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	antibodies-online proteins for TSPAN32 (3 products)
	antibodies-online peptides for TSPAN32

TSPAN32 Antibody Products:

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TSPAN32 Assay Products:

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	antibodies-online kits for TSPAN32 (4 products)

Domains /
Families
for TSPAN32 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96QS1

Find genes that share domains with TSPAN32           About GenesLikeMe

Function
for TSPAN32 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Tspan32)

genOway: Develop your customized and physiologically relevant rodent model for TSPAN32

miRNA Products:		Block miRNA regulation of human, mouse, rat TSPAN32 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate TSPAN32
		SwitchGear 3'UTR luciferase reporter plasmid: TSPAN32 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TSPAN32
		Predesigned siRNA for gene silencing in human, mouse, rat TSPAN32

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TSPAN32

Clone Products:		OriGene clones in human, mouse for TSPAN32 (see all 9) OriGene ORF clones in mouse, rat for TSPAN32 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TSPAN32 (NM_139022)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN32
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN32

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TSPAN32
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32

Localization
for TSPAN32 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	3
plasma membrane	2
golgi apparatus	1
nucleus	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for TSPAN32 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

Drugs & Compounds
for TSPAN32 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TSPAN32 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TSPAN32 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TSPAN32 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTGTAGGAC

About this image

Blood (Cardiovascular System)    fully expand to see all 2 entries
Hematopoietic Stem Cells Hematopoietic Bone Marrow
Liver (Hepatobiliary System)
Hematopoietic Stem Cells Liver Bud
Bone (Muscoskeletal System)
Chondrocytes Zeugopod Epiphyseal End
Cartilage (Muscoskeletal System)
Chondrocytes Zeugopod Epiphyseal End
Spleen (Hematopoietic System)

Primer Products:		OriGene qPCR primer pairs and template standards for TSPAN32 OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN32
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		QuantiFast Probe-based Assays in human, mouse, rat TSPAN32

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32

Orthologs
for TSPAN32 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TSPAN32 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TSPAN32 gene

1 SIMAP similar gene for TSPAN32 using alignment to 5 protein entries:     TSN32_HUMAN (see all proteins):

PHEMX

Find genes that share paralogs with TSPAN32           About GenesLikeMe

Genomic Variants
for TSPAN32 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TSPAN32 (see all 419)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1833384091,2		--	2325165(+)	AGTCCC/TACCTC	1	--	int1		0	--	--	--	--
rs1176003571,2	C,F	--	2325192(+)	GGGCCG/ATCTGA	1	--	int1		1		NA	120
rs22342951,2	C,F	--	2325239(+)	CCTCAC/TGGCCC	1	--	int1		1		NA	120
rs2021894711,2	C	--	2325290(+)	TCAGGA/GCCTGT	1	--	int1		0	--	--	--	--
rs2015309101,2		--	2325347(+)	TCTGCA/GGGGTT	2	A	syn1		0	--	--	--	--
rs2006317811,2		--	2325378(+)	CTCTGA/GGAGCC	2	R G	mis1		0	--	--	--	--
rs22342961,2	C,F,H	--	2325384(+)	GAGCCG/ATGCTG	2	/M /V	mis1 ese3		8		NS EA CSA NA EU	4985
rs1996509871,2		--	2325392(+)	CTGAGC/TGCTGC	2	S	syn1		0	--	--	--	--
rs2016344191,2	C	--	2325393(+)	TGAGCA/GCTGCA	2	T A	mis1		0	--	--	--	--
rs2006246621,2	C	--	2325414(+)	GGGAGG/TCCCAG	2	A S	mis1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TSPAN32 (2323227 - 2339430 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TSPAN32 (see all 12):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2744004	CNV	Deletion	23290073
esv2744005	CNV	Deletion	23290073
esv2744003	CNV	Deletion	23290073
esv1338872	CNV	Deletion	17803354
nsv896801	CNV	Loss	21882294
dgv999n71	CNV	Loss	21882294
nsv469928	CNV	Loss	18288195
nsv896806	CNV	Loss	21882294
nsv896776	CNV	Loss	21882294
nsv896804	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing TSPAN32

DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN32

Disorders / Diseases
for TSPAN32 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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5 diseases for TSPAN32

Selected Novoseek inferred disease relationships for TSPAN32 gene (see all 24)    About this table

Publications
for TSPAN32 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PubMed id 10950922)^{1, 2, 3, 9} Nicholson R.H.... Ko M.S.H. (Genomics 2000)
2. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PubMed id 10072438)^{1, 2, 3, 9} Lee M.P....Feinberg A.P. (Hum. Mol. Genet. 1999)
3. Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PubMed id 11718897)^{1, 2, 9} Robb L....Wright M.D. (Biochim. Biophys. Acta 2001)
4. An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PubMed id 23770605)¹ Berndt S.I....Slager S.L. (Nat. Genet. 2013)
7. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. (PubMed id 20709950)¹ Gartlan K.H....Wright M.D. (J. Immunol. 2010)
8. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)¹ Macaulay I.C....Ouwehand W.H. (Blood 2007)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. (PubMed id 10915772)¹ Paulsen M....Walter J. (Hum. Mol. Genet. 2000)

External Searches for TSPAN32 gene

Genome Databases showing TSPAN32 gene

Other Databases showing TSPAN32 gene

Specialized Databases showing TSPAN32 gene

Products
for TSPAN32 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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