Aliases for TSPAN32 Gene
Aliases for TSPAN32 Gene
External Ids for TSPAN32 Gene
- HGNC: 13410
- Entrez Gene: 10077
- Ensembl: ENSG00000064201
- OMIM: 603853
- UniProtKB: Q96QS1
Previous HGNC Symbols for TSPAN32 Gene
- TSSC6
- PHEMX
Previous GeneCards Identifiers for TSPAN32 Gene
- GC11P002280
- GC11P002113
- GC11P002323
Summaries for TSPAN32 Gene
-
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TSPAN32 Gene
TSPAN32 (Tetraspanin 32) is a Protein Coding gene. Diseases associated with TSPAN32 include Beckwith-Wiedemann Syndrome.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN32 Gene
Genomics for TSPAN32 Gene
Regulatory Elements for TSPAN32 Gene
Enhancers for TSPAN32 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TSPAN32 on UCSC Golden Path with GeneCards custom track
Promoters for TSPAN32 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TSPAN32 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TSPAN32 Gene
- Chromosome:
- 11
- Start:
- 2,301,997 bp from pter
- End:
- 2,318,201 bp from pter
- Size:
- 16,205 bases
- Orientation:
- Plus strand
Genomic View for TSPAN32 Gene
Genes around TSPAN32 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.5 by Ensembl
- 11p15.5 by Entrez Gene
- 11p15 by HGNC
TSPAN32 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TSPAN32 Gene
Proteins for TSPAN32 Gene
-
Protein details for TSPAN32 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96QS1-TSN32_HUMAN
- Recommended name:
- Tetraspanin-32
- Protein Accession:
- Q96QS1
- Q96KX4
- Q9HC50
- Q9HC51
- Q9Y5U1
Protein attributes for TSPAN32 Gene
- Size:
- 320 amino acids
- Molecular mass:
- 34631 Da
- Quaternary structure:
- No Data Available
Protein Expression for TSPAN32 Gene
Post-translational modifications for TSPAN32 Gene
Other Protein References for TSPAN32 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TSPAN32
- Invitrogen Antibodies for TSPAN32
- antibodies-online Antibodies for TSPAN32: See all 46
- GeneTex TSPAN32 antibody for TSPAN32
-
Santa Cruz Biotechnology (SCBT) Antibodies for TSPAN32
Protein Products
-
OriGene Purified Proteins for TSPAN32
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- Novus Biologicals proteins for TSPAN32
- antibodies-online Proteins for TSPAN32: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TSPAN32
Assay Products
No data available for DME Specific Peptides for TSPAN32 Gene
Domains & Families for TSPAN32 Gene
Gene Families for TSPAN32 Gene
- HGNC:
Protein Domains for TSPAN32 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TSPAN32 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96QS1- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for TSPAN32 Gene
Phenotypes for TSPAN32 Gene
- MGI mutant phenotypes for TSPAN32:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TSPAN32:
Animal Model Products
-
Taconic Biosciences Mouse Models for TSPAN32
-
ViGene Biosciences lentiviral particle packaged cDNA for TSPAN32 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
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CRISPR Products
-
OriGene CRISPR knockouts for TSPAN32
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN32
- GenScript: Design CRISPR guide RNA sequences for TSPAN32
miRNA Products
- Search ViGene Biosciences for TSPAN32
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
Clone Products
- OriGene clones in human for TSPAN32
- OriGene ORF clones in human,mouse for TSPAN32
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-
GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011519809
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- NM_139022
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TSPAN32 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TSPAN32 gene
-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN32 Gene
Localization for TSPAN32 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSPAN32 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 3 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TSPAN32 Gene
More details on SuperPathways for TSPAN32
No Data Available
Interacting Proteins for TSPAN32 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
| GO:0007229 | integrin-mediated signaling pathway | IEA | -- |
| GO:0007267 | cell-cell signaling | TAS | 10950922 |
| GO:0007596 | blood coagulation | IEA | -- |
| GO:0030886 | negative regulation of myeloid dendritic cell activation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TSPAN32 Gene
Transcripts for TSPAN32 Gene
mRNA/cDNA for TSPAN32 Gene
- (26) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (49) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TSPAN32
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN32
- GenScript: Design CRISPR guide RNA sequences for TSPAN32
miRNA Products
- Search ViGene Biosciences for TSPAN32
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for TSPAN32
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-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
Clone Products
- OriGene clones in human for TSPAN32
- OriGene ORF clones in human,mouse for TSPAN32
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011519809
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- XM_011519820
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- XM_011519822
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- XM_011519823
- XM_011519824
- XM_011519825
- XM_011519826
- XM_011519827
- XM_011519828
- XM_011519829
- NM_139022
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for TSPAN32 (TSPAN32/TSSC6)
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - |
Expression for TSPAN32 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Liver Bud
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TSPAN32 Gene
This gene is overexpressed in Whole Blood (x20.8), Heart - Left Ventricle (x5.0), and Spleen (x4.7).
This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and Platelet (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN32 Gene
SOURCE GeneReport for Unigene cluster for TSPAN32 Gene Hs.271954
mRNA Expression by UniProt/SwissProt for TSPAN32 Gene
Q96QS1-TSN32_HUMAN
Tissue specificity:
Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for TSPAN32
-
OriGene qPCR primer pairs and template standards for TSPAN32
Orthologs for TSPAN32 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | TSPAN32 35 |
|
||
| TSPAN32 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Tspan32 35 |
|
||
| Tspan32 16 |
|
||||
| Tspan32 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TSPAN32 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Phemx 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TSPAN32 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TSPAN32 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TSPAN32 35 |
|
||
| TSPAN32 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TSPAN32 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tspan32 35 |
|
- Species with no ortholog for TSPAN32:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TSPAN32 Gene
(1) SIMAP similar genes for TSPAN32 Gene using alignment to 5 proteins:
No data available for Paralogs for TSPAN32 Gene
Variants for TSPAN32 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs756925 | -- | 2,307,718(+) | AGTGC(C/T)GGGGG | intron-variant | |
| rs756926 | -- | 2,307,848(+) | GAAAG(G/T)GAGGT | intron-variant | |
| rs756927 | -- | 2,307,889(+) | GGCCA(C/T)AGCAT | intron-variant | |
| rs937614 | -- | 2,305,690(+) | GTGTC(C/G)CCAGC | intron-variant | |
| rs2074023 | -- | 2,304,351(+) | CCCCA(C/T)GTCAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv467645 | CNV | Gain | 19166990 |
| nsv896776 | CNV | Loss | 21882294 |
| nsv896801 | CNV | Loss | 21882294 |
| dgv999n71 | CNV | Loss | 21882294 |
| nsv896804 | CNV | Loss | 21882294 |
| nsv896805 | CNV | Gain+Loss | 21882294 |
| nsv896806 | CNV | Loss | 21882294 |
| nsv469928 | CNV | Loss | 18288195 |
| esv2744003 | CNV | Deletion | 23290073 |
| esv2744004 | CNV | Deletion | 23290073 |
| esv2744005 | CNV | Deletion | 23290073 |
| esv1338872 | CNV | Deletion | 17803354 |
Residual Variation Intolerance Score:
95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.74;
46.75% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN32 Gene
Disorders for TSPAN32 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| beckwith-wiedemann syndrome |
|
|
Search TSPAN32 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TSPAN32
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TSPAN32
No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN32 Gene
Publications for TSPAN32 Gene
- Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PMID: 10950922) Nicholson R.H. … Ko M.S.H. (Genomics 2000) 2 3 4 23 67
- Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PMID: 10072438) Lee M.P. … Feinberg A.P. (Hum. Mol. Genet. 1999) 2 3 23
- Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PMID: 11718897) Robb L. … Wright M.D. (Biochim. Biophys. Acta 2001) 3 23
- A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3
- Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. (PMID: 23770605) Berndt S.I. … Slager S.L. (Nat. Genet. 2013) 3
Products for TSPAN32 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- XM_011519809
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- NM_139022
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- Humanized Mice
- antibodies-online Antibodies for TSPAN32: See all 46
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- antibodies-online Proteins for TSPAN32: See all 3
- Search antibodies-online for peptides
- GeneTex TSPAN32 antibody for TSPAN32
- Search GeneTex for Proteins for TSPAN32
- ViGene Biosciences adenoviral particle packaged cDNA for TSPAN32 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TSPAN32 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TSPAN32 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
- Search ViGene Biosciences for TSPAN32
- Search ViGene Biosciences for TSPAN32
- Santa Cruz Biotechnology (SCBT) Antibodies for TSPAN32
- Search Santa Cruz Biotechnology (SCBT) for TSPAN32 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN32
Sources for TSPAN32 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
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