Aliases for TSPAN32 Gene
Aliases for TSPAN32 Gene
External Ids for TSPAN32 Gene
- HGNC: 13410
- Entrez Gene: 10077
- Ensembl: ENSG00000064201
- OMIM: 603853
- UniProtKB: Q96QS1
Previous HGNC Symbols for TSPAN32 Gene
- TSSC6
- PHEMX
Previous GeneCards Identifiers for TSPAN32 Gene
- GC11P002280
- GC11P002113
- GC11P002323
Summaries for TSPAN32 Gene
-
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TSPAN32 Gene
TSPAN32 (Tetraspanin 32) is a Protein Coding gene. Diseases associated with TSPAN32 include Beckwith-Wiedemann Syndrome.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN32 Gene
Genomics for TSPAN32 Gene
Regulatory Elements for TSPAN32 Gene
Enhancers for TSPAN32 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G002300 | 1.3 | ENCODE dbSUPER | 18.1 | +2.4 | 2355 | 7.9 | HDGF PKNOX1 CREB3L1 ARNT YY1 ZNF766 ZNF143 FOS ZNF263 REST | C11orf21 TSPAN32 RNU6-878P |
| GH11G002212 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 11.8 | -88.3 | -88300 | 2.3 | ELF3 TBP FOXA2 PKNOX1 MLX RAD21 DNMT3B THRB ZNF48 RARA | TSPAN32 ASCL2 TH GC11M002206 GC11M002224 |
| GH11G002298 | 0.9 | Ensembl ENCODE | 21.3 | -2.5 | -2468 | 1.3 | CTCF MAZ REST ZNF48 RAD21 KAT8 GLIS2 KLF16 MXD3 SMC3 | TSPAN32 C11orf21 PIR61836 |
| GH11G002209 | 1.2 | ENCODE dbSUPER | 12 | -91.5 | -91451 | 2.9 | FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 SP5 ZHX2 MXD4 NFYC | C11orf21 TSPAN32 TH ENSG00000236710 GC11M002206 MIR4686 |
| GH11G001985 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 4.5 | -309.4 | -309432 | 14.6 | HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 ARID4B DMAP1 SLC30A9 | MRPL23-AS1 IGF2 TSPAN32 SYT8 ENSG00000275266 LINC01219 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TSPAN32 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TSPAN32 Gene
- Chromosome:
- 11
- Start:
- 2,301,997 bp from pter
- End:
- 2,318,201 bp from pter
- Size:
- 16,205 bases
- Orientation:
- Plus strand
Genomic View for TSPAN32 Gene
Genes around TSPAN32 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.5 by Ensembl
- 11p15.5 by Entrez Gene
- 11p15.5 by HGNC
TSPAN32 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TSPAN32 Gene
Proteins for TSPAN32 Gene
-
Protein details for TSPAN32 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96QS1-TSN32_HUMAN
- Recommended name:
- Tetraspanin-32
- Protein Accession:
- Q96QS1
- Q96KX4
- Q9HC50
- Q9HC51
- Q9Y5U1
Protein attributes for TSPAN32 Gene
- Size:
- 320 amino acids
- Molecular mass:
- 34631 Da
- Quaternary structure:
- No Data Available
Protein Expression for TSPAN32 Gene
Post-translational modifications for TSPAN32 Gene
Other Protein References for TSPAN32 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TSPAN32
- Invitrogen Antibodies for TSPAN32
- antibodies-online Antibodies for TSPAN32: See all 46
- GeneTex TSPAN32 antibody for TSPAN32
-
Santa Cruz Biotechnology (SCBT) Antibodies for TSPAN32
Protein Products
-
OriGene Purified Proteins for TSPAN32
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- antibodies-online Proteins for TSPAN32: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TSPAN32
Assay Products
No data available for DME Specific Peptides for TSPAN32 Gene
Domains & Families for TSPAN32 Gene
Gene Families for TSPAN32 Gene
- HGNC:
Protein Domains for TSPAN32 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TSPAN32 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96QS1- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for TSPAN32 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for TSPAN32 Gene
- MGI mutant phenotypes for TSPAN32:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TSPAN32:
Animal Model Products
-
Taconic Biosciences Mouse Models for TSPAN32
-
ViGene Biosciences lentiviral particle packaged cDNA for TSPAN32 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
- Search ViGene Biosciences for TSPAN32
CRISPR Products
-
OriGene CRISPR knockouts for TSPAN32
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN32
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miRNA Products
- Search ViGene Biosciences for TSPAN32
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
Clone Products
-
OriGene ORF clones in human for TSPAN32
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-
GenScript: Next-day shipping cDNA ORF clone for TSPAN32 in any vector
- NM_139022
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Cell Line Products
-
Horizon Cell Lines for TSPAN32
-
ViGene Biosciences adenoviral particle packaged cDNA for TSPAN32 gene
-
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-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN32 Gene
Localization for TSPAN32 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSPAN32 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 3 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0009986 | cell surface | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TSPAN32 Gene
No Data Available
Interacting Proteins for TSPAN32 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
| GO:0007229 | integrin-mediated signaling pathway | IEA | -- |
| GO:0007267 | cell-cell signaling | TAS | 10950922 |
| GO:0007596 | blood coagulation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TSPAN32 Gene
Transcripts for TSPAN32 Gene
mRNA/cDNA for TSPAN32 Gene
- (19) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (49) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TSPAN32
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSPAN32
- GenScript: Design CRISPR guide RNA sequences for TSPAN32
miRNA Products
- Search ViGene Biosciences for TSPAN32
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TSPAN32
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-
ViGene Biosciences ready-to-package AAV shRNAs for TSPAN32 gene
Clone Products
-
OriGene ORF clones in human for TSPAN32
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-
GenScript: Next-day shipping cDNA ORF clone for TSPAN32 in any vector
- NM_139022
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- Sino Biological Human cDNA Clone for TSPAN32
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - |
Expression for TSPAN32 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Liver Bud
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TSPAN32 Gene
This gene is overexpressed in Whole Blood (x20.8), Heart - Left Ventricle (x5.0), and Spleen (x4.7).
This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and Platelet (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN32 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TSPAN32 Gene:
TSPAN32SOURCE GeneReport for Unigene cluster for TSPAN32 Gene:
Hs.271954mRNA Expression by UniProt/SwissProt for TSPAN32 Gene:
Q96QS1-TSN32_HUMAN
Tissue specificity:
Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen.
Evidence on tissue expression from TISSUES for TSPAN32 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for TSPAN32
-
OriGene qPCR primer pairs and template standards for TSPAN32
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN32 Gene
Orthologs for TSPAN32 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TSPAN32 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TSPAN32 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Phemx 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tspan32 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TSPAN32 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TSPAN32 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TSPAN32 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TSPAN32 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tspan32 34 |
|
- Species where no ortholog for TSPAN32 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TSPAN32 Gene
(1) SIMAP similar genes for TSPAN32 Gene using alignment to 5 proteins:
No data available for Paralogs for TSPAN32 Gene
Variants for TSPAN32 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000061442 | -- | 2,309,549(+) | GGACA(C/G)CCACG | intron-variant, nc-transcript-variant, utr-variant-5-prime | |
| rs1000126797 | -- | 2,313,864(+) | AGGGG(G/T)TTCCA | intron-variant | |
| rs1000135988 | -- | 2,299,008(+) | GTTGG(A/G)AGCAG | intron-variant, upstream-variant-2KB | |
| rs1000249125 | -- | 2,318,351(+) | TGTGT(C/G)GGGTC | downstream-variant-500B | |
| rs1000271975 | -- | 2,298,835(+) | ATGAA(A/G)GGGCA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1338872 | CNV | deletion | 17803354 |
| esv2744003 | CNV | deletion | 23290073 |
| esv2744004 | CNV | deletion | 23290073 |
| esv2744005 | CNV | deletion | 23290073 |
| esv3625125 | CNV | gain | 21293372 |
| nsv467645 | CNV | gain | 19166990 |
| nsv469928 | CNV | loss | 18288195 |
| nsv553047 | CNV | gain | 21841781 |
| nsv553081 | CNV | loss | 21841781 |
| nsv553086 | CNV | loss | 21841781 |
| nsv951285 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.74;
46.75% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TSPAN32 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TSPAN32
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN32 Gene
Disorders for TSPAN32 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| beckwith-wiedemann syndrome |
|
|
Search TSPAN32 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TSPAN32
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TSPAN32
No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN32 Gene
Publications for TSPAN32 Gene
- Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PMID: 10950922) Nicholson R.H. … Ko M.S.H. (Genomics 2000) 2 3 4 22 64
- Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PMID: 10072438) Lee M.P. … Feinberg A.P. (Hum. Mol. Genet. 1999) 2 3 4 22 64
- Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PMID: 11718897) Robb L. … Wright M.D. (Biochim. Biophys. Acta 2001) 3 4 22 64
- An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for TSPAN32 Gene
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- antibodies-online Antibodies for TSPAN32: See all 46
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- GeneTex TSPAN32 antibody for TSPAN32
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- ViGene Biosciences adenoviral particle packaged cDNA for TSPAN32 gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TSPAN32 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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