Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPAN32 Gene

protein-coding   GIFtS: 49
GCID: GC11P002323

tetraspanin 32

(Previous name: pan-hematopoietic expression )
(Previous symbols: TSSC6, PHEMX)
 Explore 42 diseases affiliated with
TSPAN32 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TSPAN32    

Aliases
for TSPAN32 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tetraspanin 321 2     Pan-Hematopoietic Expression Protein2
PHEMX1 2 3 5     Tetraspanin-321
TSSC61 2 3 5     Tspan-323
Protein Phemx2 3     Tumor-Suppressing STF CDNA 62
Pan-Hematopoietic Expression1     Tumor-Suppressing Subchromosomal Transferable Fragment CDNA 62
ART12     Tumor-Suppressing Subtransferable Candidate 62
PHMX2     Tspan-323

External Ids:    HGNC: 134101   Entrez Gene: 100772   Ensembl: ENSG000000642017   OMIM: 6038535   UniProtKB: Q96QS13   

Export aliases for TSPAN32 gene to outside databases

Previous GC identifers: GC11P002280 GC11P002113


Summaries
for TSPAN32 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TSPAN32:
This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable
fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region.
Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma,
adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes;
however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This
gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic
cell function. Alternatively spliced transcript variants have been described, but their biological validity has not
been determined. (provided by RefSeq, Jul 2008)

Gene Wiki entry for TSPAN32


Genomic Views
for TSPAN32 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPAN32 gene promoter:
         Elk-1   RP58   GATA-3   NCX/Ncx   MyoD   CREB   GATA-6   deltaCREB   HOXA5   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSPAN32 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPAN32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15

TSPAN32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN32 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002323:  view genomic region     (about GC identifiers)

Start:
 2,323,227 bp from pter      End:
 2,339,430 bp from pter
Size:
 16,204 bases      Orientation:
 plus strand

Proteins
for TSPAN32 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1 (See protein sequence)
Recommended Name: Tetraspanin-32  
Size: 320 amino acids; 34631 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Developmental stage: Expressed from early embryogenesis through to adulthood
Secondary accessions: Q96KX4 Q9HC50 Q9HC51 Q9Y5U1
Alternative splicing: 5 isoforms:  Q96QS1-1   Q96QS1-2   Q96QS1-3   Q96QS1-4   Q96QS1-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TSPAN32: NX_Q96QS1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96QS1

    • TSPAN32 Protein expression data from MOPED and PaxDb:    About this image 
    TSPAN32 Protein Expression
    REFSEQ proteins: NP_620591.3  
    ENSEMBL proteins: 
     ENSP00000405001   ENSP00000182290   ENSP00000395018   ENSP00000370513   ENSP00000343285  
     ENSP00000405205   ENSP00000388033   ENSP00000370509  

    Human Recombinant Protein Products for TSPAN32: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TSPAN32 
    GenScript Custom Purified and Recombinant Proteins Services for TSPAN32
    Novus Biologicals TSPAN32 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TSPAN32

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0016021integral to membrane NAS--

    TSPAN32 for ontologies           About GeneDecksing



    TSPAN32 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: TSPAN32
    OriGene Custom Antibody Services for TSPAN32 
    GenScript Custom Superior Antibodies Services for TSPAN32
    Novus Biologicals TSPAN32 Antibodies
    Abcam antibodies for TSPAN32 
    Uscn Antibodies for TSPAN32
    ThermoFisher Antibody for TSPAN32

    Assay Products for TSPAN32: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSPAN32
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TSPAN32

    Protein Domains /
    Families
    for TSPAN32 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TSPAN32 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2

    Graphical View of Domain Structure for InterPro Entry Q96QS1

    ProtoNet protein and cluster: Q96QS1

    UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Function
    for TSPAN32 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TSPAN32 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tspan32):
     cellular  hematopoietic system  immune system 

    TSPAN32 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TSPAN32 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN32
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TSPAN32
    SwitchGear 3'UTR luciferase reporter plasmid: TSPAN32 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN32 (see all 4)
    OriGene shRNA RFP: TSPAN32
    OriGene siRNA: TSPAN32
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN32
    Sirion Biotech Custom design and validation of potent shRNA sequences against TSPAN32 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TSPAN32
    Sirion Biotech Customized adenovirus for overexpression of TSPAN32 
    Sirion Biotech Customized adenovirus for potent knockdown of TSPAN32

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN32 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TSPAN32 (NM_139022)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN32 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TSPAN32
    Search LifeMap BioReagents cell lines for TSPAN32
    Sirion Biotech Customized stable knockdown cell line services for TSPAN32 
    Sirion Biotech Customized inducible knockdown cell line services for TSPAN32
    Sirion Biotech Customized stable overexpressing cell line services for TSPAN32
    Sirion Biotech Customized inducible overexpressing cell line services for TSPAN32

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32


    Pathways & Interactions
    for TSPAN32 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN32

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling TAS10950922

    TSPAN32 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TSPAN32 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TSPAN32 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSPAN32
    7 Novoseek chemical compound relationships for TSPAN32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ganglioside 44.3 4 15334254 (1), 12068006 (1), 15710618 (1), 19559406 (1)
    tyrosine 31 6 10427099 (1), 12938224 (1), 12110679 (1), 19166707 (1) (see all 5)
    lipid 27.3 9 15454569 (1), 15496196 (1), 16785325 (1), 19497983 (1) (see all 9)
    phosphatidylinositol 23.4 2 12110679 (1), 11739647 (1)
    cysteine 23.2 5 20171294 (2), 11907260 (1), 14556650 (1), 12575999 (1)
    cholesterol 5.22 23 12938224 (5), 15184367 (2), 15454569 (1), 19497983 (1) (see all 5)
    polysaccharide 0 1 12701754 (1)

    Search CenterWatch for drugs/clinical trials and news about TSPAN32 / TSN32 

    Transcripts
    for TSPAN32 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSPAN32 gene (3 alternative transcripts): 
    NM_139022.2  NM_005705.4  NM_139024.3  

    Unigene Cluster for TSPAN32:

    Tetraspanin 32
    Hs.271954  [show with all ESTs]
    Unigene Representative Sequence: AK298692
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437313 ENST00000461200(uc001lvx.1 uc009ydk.1 uc010qxk.2 uc001lvy.1 uc009ydl.1 uc001lwb.1 uc001lwc.1 uc001lwd.1)
    ENST00000182290 ENST00000446063 ENST00000493924 ENST00000484104 ENST00000479508
    ENST00000498313 ENST00000483227 ENST00000381121 ENST00000493948 ENST00000339046
    ENST00000451520(uc001lvz.1) ENST00000444307 ENST00000468578 ENST00000381117
    ENST00000484523 ENST00000486011

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN32
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TSPAN32
    SwitchGear 3'UTR luciferase reporter plasmid: TSPAN32 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN32 (see all 4)
    OriGene shRNA RFP: TSPAN32
    OriGene siRNA: TSPAN32
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN32
    Sirion Biotech Custom design and validation of potent shRNA sequences against TSPAN32 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN32 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TSPAN32 (NM_139022)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN32 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN32
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN32
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN32
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN32

    Additional cDNA sequence: 

    AF176071.1 AK298692.1 AK307638.1 AK310116.1 AY039001.1 AY303780.1 BC016693.1 

    11 DOTS entries:

    DT.95168325  DT.111418  DT.95094062  DT.111419  DT.91648803  DT.97812022  DT.91656368  DT.120684722 
    DT.95168321  DT.95168322  DT.40314344 

    24/49 AceView cDNA sequences (see all 49):

    AW440888 AA701395 BI906333 AY039001 AF176070 BX117724 NM_139024 NM_139022 
    CR606621 BG506933 AF125569 AA913945 N99620 BI909345 BI907377 AK128812 
    NM_005705 AF176071 BI518496 AY303780 BC016693 BI909447 BV196160 BM926073 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN32 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:              -     -     -                 -           -                             -     -     -                                             
    SP2:              -     -     -                 -           -                             -     -     -           -                                 
    SP3:                                            -           -                 -           -     -     -                                             
    SP4:                                            -           -                             -     -     -                                             
    SP5:                                            -           -     -                       -     -     -                                             


    ECgene alternative splicing isoforms for TSPAN32

    Expression
    for TSPAN32 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSPAN32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGTAGGAC
    TSPAN32 Expression
    About this image

    TSPAN32 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See TSPAN32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSPAN32

    SOURCE GeneReport for Unigene cluster: Hs.271954

    UniProtKB/Swiss-Prot: TSN32_HUMAN, Q96QS1
    Tissue specificity: Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic
    tissues including peripheral blood leukocytes, thymus and spleen

        SABiosciences Custom PCR Arrays for TSPAN32
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN32
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN32
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN32
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN32
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32

    Orthologs
    for TSPAN32 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TSPAN32 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tspan321 , 5 tetraspanin 321, 5 76.02(n)1
    64.03(a)1    		   7 (88.09 cM)5
    270271  NM_001128080.21  NP_001121552.11 
     1430050465 
    chicken
    (Gallus gallus)    		 Aves TSPAN321 tetraspanin 32 59.82(n)
    47.49(a)    		   395087  XM_421025.2  XP_421025.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TSPAN326
    		 --
    		 52(a)
    		 1 ↔ 1
    		 1(69690114-69698244)


    ENSEMBL Gene Tree for TSPAN32 (if available)
    TreeFam Gene Tree for TSPAN32 (if available) 

    Paralogs
    for TSPAN32 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TSPAN32 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 NCBI SNPs in TSPAN32 are shown (see all 411)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs763951941,2
    		C--2321250(+) AACCCG/ACTGCT 3 -- int1 us2k12Minor allele frequency- A:0.07NA 122
    rs1114476041,2
    		C--2321279(+) CCCAGC/TGGCCG 3 -- int1 us2k11Minor allele frequency- T:0.50NA 2
    rs1475056221,2
    		--2321283(+) GCGGCC/TGGCAC 3 -- us2k1 int10--------
    rs122249671,2
    		C,F--2321284(+) CGGCCA/GGCACC 3 -- int1 us2k15Minor allele frequency- G:0.45NA CSA EA 245
    rs734044791,2
    		C--2321306(+) AGGTGG/CGCAGG 3 -- int1 us2k11Minor allele frequency- C:0.50WA 2
    rs618715611,2
    		--2321392(+) GGGGCA/GTGTGG 3 -- int1 us2k10--------
    rs26518231,2
    		C,F--2321650(+) GAGGGG/AATGTT 3 -- us2k1 int111Minor allele frequency- A:0.39NA WA CSA EA 372
    rs128021871,2
    		H--2321677(+) GCTCAG/TCAAAG 3 -- us2k1 int1 tfbs34Minor allele frequency- T:0.00NS EA 420
    rs797197141,2
    		--2321693(+) GGGGGA/TTCCAC 3 -- int1 us2k10--------
    rs22855681,2
    		C,F,H--2321899(+) TGCTCC/TGAAAT 3 -- int1 us2k19Minor allele frequency- T:0.05EA NS NA CSA 2100

    HapMap Linkage Disequilibrium report for TSPAN32 (2323227 - 2339430 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TSPAN32
         1 CNV: 29896
         1 Indel: 24696

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN32
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN32

    Disorders / Diseases
    for TSPAN32 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TSPAN32 for disorders           About GeneDecksing

    OMIM gene information: 603853    OMIM disorders: --

    40/42 diseases for TSPAN32 (see all 42) (see first 20):    About MalaCards
    beckwith-wiedemann syndrome    disseminated intravascular coagulation    breast cancer    carcinoma
    adrenocortical carcinoma    alveolar echinococcosis    mental retardation epilepsy    wilms tumor
    echinococcosis    oral squamous cell carcinoma    merkel cell carcinoma    retinal degeneration
    squamous cell carcinoma    rhabdomyosarcoma    diphtheria    schistosomiasis
    rheumatoid arthritis    hepatitis c    multiple myeloma    eczema
    epilepsy syndrome    colon cancer    myeloma    melanoma metastasis
    lung cancer    retinitis    arthritis    melanoma
    colon carcinoma    hepatocellular carcinoma    ovarian carcinoma    gastric cancer
    hepatitis    immunodeficiency    prostate carcinoma    osteosarcoma
    adenocarcinoma    prostatitis    prostate cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for TSPAN32:
    Beckwith-Wiedemann syndrome

    10/24 Novoseek disease relationships for TSPAN32 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 52.3 50 16823699 (3), 19078974 (3), 19363832 (2), 16467180 (2) (see all 33)
    hepatitis c 39.2 10 11226150 (2), 15449903 (1), 11134943 (1), 18836553 (1) (see all 9)
    cancer 37.4 19 15205336 (1), 16823699 (1), 16944980 (1), 18395972 (1) (see all 16)
    pathological processes 32.1 4 19251723 (1), 19703604 (1), 16404722 (1), 16467180 (1)
    tumors 30.6 25 12579280 (2), 15205336 (1), 15533898 (1), 16823699 (1) (see all 22)
    primary tumor 25.7 5 16467180 (2), 16404722 (1), 17582603 (1)
    myeloma 23.9 2 18804164 (1), 16113057 (1)
    colon cancer 23 4 16467180 (2), 16404722 (1)
    immunodeficiency 16.7 4 16775336 (1), 18836553 (1), 17522207 (1), 19458002 (1)
    schistosomiasis 11.1 2 9756983 (1), 17222846 (1)


    Export disorders for TSPAN32 gene to outside databases

    Publications
    for TSPAN32 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSPAN32 gene, integrated from 9 sources (see all 227):
    (articles sorted by number of sources associating them with TSPAN32)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. (PubMed id 10950922)1, 2, 3, 9 Nicholson R.H.... Ko M.S.H. (2000)
    2. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PubMed id 10072438)1, 2, 3, 9 Lee M.P....Feinberg A.P. (1999)
    3. Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. (PubMed id 11718897)1, 2, 9 Robb L....Wright M.D. (2001)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A complementary role for the tetraspanins CD37 and Ts sc6 in cellular immunity. (PubMed id 20709950)1 Gartlan K.H....Wright M.D. (2010)
    7. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. (PubMed id 10915772)1 Paulsen M....Walter J. (2000)
    10. A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. (PubMed id 9403053)1 Hu R.-J.... Feinberg A.P. (1997)

    External Searches for TSPAN32 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TSPAN32 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10077 HGNC: 13410 AceView: PHEMX Ensembl:ENSG00000064201 euGenes: HUgn10077
    ECgene: TSPAN32 H-InvDB: TSPAN32

    Other Databases showing TSPAN32 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TSPAN32 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSPAN32 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPAN32 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TSPAN32 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TSPAN32 gene:
    Search GeneIP for patents involving TSPAN32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TSPAN32 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TSPAN32   OriGene shRNA RFP for TSPAN32  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN32   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN32  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TSPAN32   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN32   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN32  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSPAN32   OriGene Custom Protein Services for TSPAN32  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN32
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN32
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN32
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN32
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN32
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN32
     GenScript Custom Purified and Recombinant Proteins Services for TSPAN32 GenScript cDNA clones with any tag delivered in your preferred vector for TSPAN32
     GenScript Custom Assay Services for TSPAN32 GenScript Custom Superior Antibodies Services for TSPAN32
     GenScript Custom overexpressing Cell Line Services for TSPAN32 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSPAN32 promoter
     Search Chromatin IP Primers for TSPAN32
     RT2 qPCR Primer Assay in human, mouse, rat TSPAN32
     Search GNC Networks for TSPAN32
     SABiosciences Custom PCR Arrays for TSPAN32
     Search Tocris compounds for TSPAN32
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSPAN32 antibodies
     TSPAN32 proteins
     Antibodies for TSPAN32
     See all of Abcam's Antibodies, Kits and Proteins for TSPAN32
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TSPAN32 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TSPAN32
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN32
     SwitchGear 3'UTR luciferase reporter plasmids for TSPAN32
     SwitchGear Promoter luciferase reporter plasmids for TSPAN32
     ThermoFisher Antibody for TSPAN32
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN32
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TSPAN32
    Sirion Biotech Customized:
     stable knockdown cell line services for TSPAN32
     inducible knockdown cell line services for TSPAN32
     design and validation of potent shRNA sequences against TSPAN32
     adenovirus for potent knockdown of TSPAN32
     adenovirus for overexpression of TSPAN32
     stable overexpressing cell line services for TSPAN32
     inducible overexpressing cell line services for TSPAN32
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TSPAN32 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4