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Aliases for TSPAN31 Gene

Aliases for TSPAN31 Gene

  • Tetraspanin 31 2 3 5
  • Sarcoma Amplified Sequence 2 3
  • Sarcoma-Amplified Sequence 3 4
  • Tspan-31 3 4
  • SAS 3 4
  • Transmembrane 4 Protein 3

External Ids for TSPAN31 Gene

Previous HGNC Symbols for TSPAN31 Gene

  • SAS

Previous GeneCards Identifiers for TSPAN31 Gene

  • GC12P056426
  • GC12P058138
  • GC12P055175

Summaries for TSPAN31 Gene

Entrez Gene Summary for TSPAN31 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN31 Gene

TSPAN31 (Tetraspanin 31) is a Protein Coding gene. Diseases associated with TSPAN31 include Liposarcoma and Atypical Lipomatous Tumor. An important paralog of this gene is TSPAN13.

Gene Wiki entry for TSPAN31 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN31 Gene

Genomics for TSPAN31 Gene

Regulatory Elements for TSPAN31 Gene

Enhancers for TSPAN31 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN31 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN31 Gene

57,738,013 bp from pter
57,750,211 bp from pter
12,199 bases
Plus strand

Genomic View for TSPAN31 Gene

Genes around TSPAN31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN31 Gene

Proteins for TSPAN31 Gene

  • Protein details for TSPAN31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O00577
    • Q53X76

    Protein attributes for TSPAN31 Gene

    210 amino acids
    Molecular mass:
    23053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN31 Gene

Proteomics data for TSPAN31 Gene at MOPED

Post-translational modifications for TSPAN31 Gene

  • Glycosylation at Asn 100, Asn 109, Asn 117, and Asn 134
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN31 Gene

No data available for DME Specific Peptides for TSPAN31 Gene

Domains & Families for TSPAN31 Gene

Gene Families for TSPAN31 Gene

Protein Domains for TSPAN31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN31: view

Function for TSPAN31 Gene

Phenotypes for TSPAN31 Gene

genes like me logo Genes that share phenotypes with TSPAN31: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN31

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN31 Gene

Localization for TSPAN31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN31 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN31 Gene COMPARTMENTS Subcellular localization image for TSPAN31 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 8134123
genes like me logo Genes that share ontologies with TSPAN31: view

Pathways & Interactions for TSPAN31 Gene

SuperPathways for TSPAN31 Gene

No Data Available

Interacting Proteins for TSPAN31 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000257910 Q12999-TSN31_HUMAN for TSPAN31 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TSPAN31 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSPAN31 Gene

Drugs & Compounds for TSPAN31 Gene

(1) Drugs for TSPAN31 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Somatropin recombinant Approved, Investigational Pharma 0
genes like me logo Genes that share compounds with TSPAN31: view

Transcripts for TSPAN31 Gene

Unigene Clusters for TSPAN31 Gene

Tetraspanin 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP8: -

Relevant External Links for TSPAN31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN31 Gene

mRNA expression in normal human tissues for TSPAN31 Gene

Protein differential expression in normal tissues from HIPED for TSPAN31 Gene

This gene is overexpressed in Pancreas (30.3), Colon (12.1), and Fetal gut (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN31 Gene

SOURCE GeneReport for Unigene cluster for TSPAN31 Gene Hs.632708

genes like me logo Genes that share expression patterns with TSPAN31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPAN31 Gene

Orthologs for TSPAN31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN31 35
  • 93.81 (n)
  • 96.19 (a)
TSPAN31 36
  • 96 (a)
(Canis familiaris)
Mammalia TSPAN31 35
  • 94.13 (n)
  • 97.14 (a)
SAS 36
  • 85 (a)
(Mus musculus)
Mammalia Tspan31 35
  • 86.51 (n)
  • 88.1 (a)
Tspan31 16
Tspan31 36
  • 88 (a)
(Pan troglodytes)
Mammalia TSPAN31 35
  • 99.84 (n)
  • 100 (a)
TSPAN31 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan31 35
  • 85.87 (n)
  • 88.1 (a)
(Anolis carolinensis)
Reptilia TSPAN31 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10756 35
tspan31 35
  • 67.15 (n)
  • 72.73 (a)
(Danio rerio)
Actinopterygii sas 35
  • 65.87 (n)
  • 71.77 (a)
zgc56710 35
sas 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp97E 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10763 36
  • 42 (a)
Species with no ortholog for TSPAN31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN31 Gene

Gene Tree for TSPAN31 (if available)
Gene Tree for TSPAN31 (if available)

Paralogs for TSPAN31 Gene

Paralogs for TSPAN31 Gene

(2) SIMAP similar genes for TSPAN31 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TSPAN31: view

Variants for TSPAN31 Gene

Sequence variations from dbSNP and Humsavar for TSPAN31 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs28364702 -- 57,745,041(+) AGTAT(C/T)GGGTT reference, missense, utr-variant-5-prime
rs79961948 -- 57,745,377(+) GAGAG(-/GAG)ACTTC intron-variant
rs111263678 -- 57,745,946(+) CCGGG(A/G)GCTTG intron-variant
rs35187428 -- 57,745,470(+) ACCTC(-/A)AGTTT intron-variant
rs111737335 -- 57,746,452(+) AGGTA(G/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN31 Gene

Variant ID Type Subtype PubMed ID
nsv899121 CNV Loss 21882294
nsv470296 CNV Loss 18288195
nsv899123 CNV Loss 21882294
nsv826384 CNV Gain 20364138
nsv510601 CNV Loss 20534489
nsv470297 CNV Gain 18288195
nsv826386 CNV Gain 20364138
nsv819021 CNV Loss 19587683

Variation tolerance for TSPAN31 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN31 Gene

Disorders for TSPAN31 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSPAN31 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
atypical lipomatous tumor
  • pleomorphic lipoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSPAN31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN31 Gene

Publications for TSPAN31 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (PMID: 15024701) Ragazzini P. … Benassi M.S. (Histol. Histopathol. 2004) 3 23
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for TSPAN31 Gene

Sources for TSPAN31 Gene