TSPAN31 Gene
protein-coding GIFtS: 51
GCID: GC12P058138
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tetraspanin 31(Previous name: sarcoma amplified sequence ) (Previous symbol: SAS)
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Aliases for TSPAN31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Tetraspanin 311 2 | | Tetraspanin-311 | | SAS1 2 3 5 | | Transmembrane 4 Protein2 | | Sarcoma Amplified Sequence1 2 | | Tspan-313 | | Sarcoma-Amplified Sequence2 3 | | Tspan-313 |
Export aliases for TSPAN31 gene to outside databasesPrevious GC identifers: GC12P056426 GC12P055175 |
Summaries for TSPAN31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TSPAN31: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene isassociated with tumorigenesis and osteosarcoma. (provided by RefSeq, Jul 2008) Gene Wiki entry for TSPAN31
|
Genomic Views for TSPAN31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TSPAN31 gene promoter: E2F-3a c-Fos AP-1 E2F-2 c-Jun NF-kappaB NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPAN31
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN31 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13-q14TSPAN31 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P058138: view genomic region
(about GC identifiers)
Start:
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58,131,796 bp from pter |
End:
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58,143,994 bp from pter |
Size:
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12,199 bases |
Orientation:
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plus strand |
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Proteins for TSPAN31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TSN31_HUMAN, Q12999 (See
protein sequence)Recommended Name: Tetraspanin-31 Size: 210 amino acids; 23053 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O00577 Q53X76Explore the universe of human proteins at neXtProt for TSPAN31: NX_Q12999
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12999 TSPAN31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005972.1 ENSEMBL proteins: ENSP00000257910 ENSP00000448209 ENSP00000449312 ENSP00000446482 ENSP00000450195 ENSP00000449199 ENSP00000449131 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TSPAN31 for ontologies About GeneDecksing
TSPAN31 Antibody Products: Assay Products for TSPAN31: |
Protein
Domains / Families for TSPAN31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPAN31 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q12999ProtoNet protein and cluster: Q12999 1 Blocks protein family: IPB000301 Transmembrane four family signature
UniProtKB/Swiss-Prot: TSN31_HUMAN, Q12999Similarity: Belongs to the tetraspanin (TM4SF) family |
Function for TSPAN31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN31 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN31 |
Animal Models: 1 MGI phenotypic allele for Tspan31 (no phenotypes)
TSPAN31 for phenotypes About GeneDecksing
|
Pathways & Interactions for TSPAN31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN31
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 3 Interacting proteins for TSPAN31 (Q129993 ENSP000002579104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008284 | positive regulation of cell proliferation |
TAS | 8134123 |
TSPAN31 for ontologies About GeneDecksing
|
Drugs & Compounds for TSPAN31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TSPAN31 Search CenterWatch for drugs/clinical trials and news about TSPAN31 / TSN31 
|
Transcripts for TSPAN31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TSPAN31 gene: NM_005981.3 Unigene Cluster for TSPAN31: Tetraspanin 31 Hs.632708 [show with all ESTs]Unigene Representative Sequence: AB20969914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000553221 ENST00000547311 ENST00000550528 ENST00000257910(uc001spt.3 uc009zqb.3 uc010ssa.2) ENST00000547992 ENST00000552816 ENST00000553089 ENST00000549052 ENST00000546993 ENST00000547472 ENST00000548093 ENST00000548167 ENST00000550791 ENST00000546922
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN31 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSPAN31 (NM_005981) | |  | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AB209699.1 AK294128.1 AK315765.1 BC010377.1 BX647402.1 CR407647.1 U01160.1 19 DOTS entries: DT.92408932 DT.40113477 DT.445603 DT.100800137 DT.219465 DT.100851448 DT.121198928 DT.121642996 DT.121198876 DT.100701711 DT.121198875 DT.95093290 DT.100667381 DT.100701713 DT.100701889 DT.121198723 DT.95339116 DT.100851460 DT.121198852 24/198 AceView cDNA sequences (see all 198): BX416207 BQ072508 CD672750 CR407647 AA301604 CA449236 NM_005981 AA772366 BE350825 AI281002 BQ436397 CA394386 U01160 BI822098 CR623983 CK821636 BM462177 BM920971 BM544408 AW409777 AU136058 BF037005 AU103105 CA406334 GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN31 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TSPAN31
|
Expression for TSPAN31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPAN31 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CCAGATGTGT
About this image See TSPAN31 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSPAN31
SOURCE GeneReport for Unigene cluster: Hs.632708 SABiosciences Custom PCR Arrays for TSPAN31
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN31 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN31 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN31 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN31 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN31 |
Orthologs for TSPAN31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSPAN31 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Tspan311 , 5 |
tetraspanin 311, 5 |
86.51(n)1 88.1(a)1 |
  |
10 (74.50 cM)5 671251 NM_025982.41 NP_080258.11 1270673175 |
lizard (Anolis carolinensis) |
Reptilia |
TSPAN316 |
-- |
71(a) |
1 ↔ 1 |
2(66647334-66669461) |
African clawed frog (Xenopus laevis) |
Amphibia |
BC043968.12 |
-- |
75.22(n) |
  |
BC043968.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc567102 |
similar to sarcoma amplified sequence |
75.45(n) |
  |
393251 AY398411.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Tsp97E6 |
Tetraspanin 97E |
39(a) |
1 → many |
3R(22787446-22790547) |
ENSEMBL Gene Tree for TSPAN31 (if available) TreeFam Gene Tree for TSPAN31 (if available)  |
Paralogs for TSPAN31 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TSPAN31 gene
- TSPAN132
2 SIMAP similar genes for TSPAN31 using alignment to 8 protein entries: TSN31_HUMAN (see all proteins):TM4SF13 TSPAN13
TSPAN31 for paralogs About GeneDecksing
|
Genomic Variants for TSPAN31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TSPAN31 (58131796 - 58143994 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TSPAN31 1 CNV: 58587  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN31 |
|
Disorders
/ Diseases for TSPAN31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPAN31 for disorders About GeneDecksing
OMIM gene information: 181035
OMIM disorders: --
14 diseases for TSPAN31: About MalaCardsosteosarcoma fibrous histiocytoma sarcoma malignant fibrous histiocytoma histiocytoma embryonal rhabdomyosarcoma chondroma lipoma rhabdomyosarcoma liposarcoma leiomyosarcoma hepatitis b hepatitis neuroblastoma 3 diseases from the University of Copenhagen DISEASES database for TSPAN31:Liposarcoma Malignant fibroxanthoma Chondroma Human Genome Epidemiology (HuGE) Navigator: TSPAN31 (4 documents) Export disorders for TSPAN31 gene to outside databases
|
Publications for TSPAN31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPAN31 gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with TSPAN31) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. (PubMed id 9192850)1, 2 Elkahloun A.G....Meltzer P.S. (1997)
- SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. (PubMed id 8134123)1, 2 Jankowski S.A.... Meltzer P.S. (1994)
- Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (PubMed id 15024701)1, 9 Ragazzini P....Benassi M.S. (2004)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TSPAN31 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TSPAN31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPAN31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPAN31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for TSPAN31 gene: Search GeneIP for patents involving TSPAN31
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TSPAN31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN31 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN31 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN31 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN31 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN31 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN31 |
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 | | TSPAN31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN31 |
|  |  |  | | | Search ThermoFisher Antibodies for TSPAN31 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN31 |
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