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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TSPAN3 Gene

protein-coding GIFtS: 55
GCID: GC15M077336

tetraspanin 3

(Previous name: transmembrane 4 superfamily member 8 )
(Previous symbol: TM4SF8)

Explore 4 diseases affiliated with
TSPAN3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tetraspanin 3¹ ²		Tetraspanin TM4-A² ³
Transmembrane 4 Superfamily Member 8¹ ² ³		Tetraspan 3²
TM4SF8¹ ² ³		Tetraspan TM4SF²
TM4-A¹ ²		Tetraspanin-3¹
TSPAN-3¹ ²		Tspan-3³

External Ids:	HGNC: 17752¹	Entrez Gene: 10099²	Ensembl: ENSG00000140391⁷	OMIM: 613134⁵	UniProtKB: O60637³

Export aliases for TSPAN3 gene to outside databases

Previous GC identifers: GC15M075126 GC15M075127 GC15M054093

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSPAN3:

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.

Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,

growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative

transcripts encoding different isoforms have been described. (provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: TSN3_HUMAN, O60637

Function: Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and

repair (By similarity)

Gene Wiki entry for TSPAN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TSPAN3 gene promoter:
SREBP-1c Nkx2-5 SREBP-1b Evi-1 GATA-1 C/EBPalpha MZF-1 SREBP-1a IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSPAN3 promoter sequence

Search SABiosciences Chromatin IP Primers for TSPAN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3 Ensembl cytogenetic band: 15q24.3 HGNC cytogenetic band: 15q23

TSPAN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M077336: view genomic region (about GC identifiers)

Start:	77,336,359 bp from pter	End:	77,376,326 bp from pter
Size:	39,968 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSN3_HUMAN, O60637 (See protein sequence)

Recommended Name: Tetraspanin-3

Size: 253 amino acids; 28018 Da

Subunit: Interacts with claudin-11/CLDN11 and integrins (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Secondary accessions: A6NEH4 B3KQQ2 B4DP19 Q9BW22 Q9NVX9

Alternative splicing: 3 isoforms: O60637-1 O60637-2 O60637-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSPAN3: NX_O60637

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60637

TSPAN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001161884.1 NP_005715.1 NP_944492.1

ENSEMBL proteins:

ENSP00000267970 ENSP00000341329 ENSP00000407243 ENSP00000453613 ENSP00000452835

ENSP00000453868

Human Recombinant Protein Products:

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	Uscn Proteins for TSPAN3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TSPAN3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TSPAN3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TSPAN3 for domains About GeneDecksing

4 InterPro domains/families:

IPR018499 Tetraspanin/Peripherin

IPR018503 Tetraspanin_CS

IPR000301 Tetraspanin

IPR008952 Tetraspanin_EC2

Graphical View of Domain Structure for InterPro Entry O60637

ProtoNet protein and cluster: O60637

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: TSN3_HUMAN, O60637

Similarity: Belongs to the tetraspanin (TM4SF) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TSN3_HUMAN, O60637

Function: Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and

repair (By similarity)

miRNA Products:		miRTarBase miRNAs that target TSPAN3: hsa-mir-197 (MIRT000215)

		OriGene 3'-UTR Clone (see all 2): TSPAN3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN3
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN3 (see all 65):
		hsa-miR-21* hsa-miR-323-3p hsa-miR-142-5p hsa-miR-136 hsa-miR-607 hsa-miR-1197 hsa-miR-1914* hsa-miR-199a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: TSPAN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN3 (see all 7) OriGene shRNA RFP: TSPAN3 OriGene siRNA: TSPAN3
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TSPAN3

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		Search LifeMap BioReagents cell lines for TSPAN3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TSPAN3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/7 Interacting proteins for TSPAN3 (O60637^{2, 3} ENSP00000267970⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLDN11	O75508³, ENSP00000064724⁴	I2D: score=2 STRING: ENSP00000064724
EWSR1	Q01844³, ENSP00000381031⁴	I2D: score=3 STRING: ENSP00000381031
ITGB1	P05556³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
--	Q9BWA2³^,²	MINT-67828 I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSPAN3
Search CenterWatch for drugs/clinical trials and news about TSPAN3 / TSN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPAN3 gene (3 alternative transcripts):

NM_001168412.1 NM_005724.5 NM_198902.2

Unigene Cluster for TSPAN3:

Tetraspanin 3

Hs.5062 [show with all ESTs]

Unigene Representative Sequence: NM_005724

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000267970(uc002bcj.3 uc002bck.3 uc010ump.2) ENST00000560715

ENST00000346495 ENST00000424443 ENST00000561277 ENST00000559494 ENST00000558745

ENST00000558394 ENST00000560514 ENST00000559373

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TSPAN3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN3
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN3 (see all 65):
		hsa-miR-21* hsa-miR-323-3p hsa-miR-142-5p hsa-miR-136 hsa-miR-607 hsa-miR-1197 hsa-miR-1914* hsa-miR-199a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: TSPAN3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN3 (see all 7) OriGene shRNA RFP: TSPAN3 OriGene siRNA: TSPAN3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN3

Additional cDNA sequence:

AF054840.1 AF133423.1 AK001305.1 AK001310.1 AK001326.1 AK027793.1 AK075336.1 AK075482.1

AK125434.1 AK293677.1 AK298157.1 BC000704.2 BC004280.1 BC009248.2 BC011206.1 M69023.1

24/27 DOTS entries (see all 27):

DT.100637592 DT.100667198 DT.80100587 DT.100667195 DT.100667197 DT.401301 DT.308517 DT.121065937

DT.95082083 DT.100667190 DT.100847334 DT.121065985 DT.100641991 DT.100845011 DT.92458097 DT.100667194

DT.100680471 DT.100860629 DT.121065903 DT.121065922 DT.121065924 DT.121065961 DT.121065998 DT.92458099

24/673 AceView cDNA sequences (see all 673):

T90734 BP362892 BQ028744 CR625746 CR597854 AI623847 CR620957 BQ638370

CD243225 AI689360 CN481853 BM475064 AW128929 BP347423 BU689682 BP363324

BU183577 CR609168 AI028433 BM808058 BF507373 AI026978 BU689298 CR607094

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN3 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8
SP1:											-
SP2:											-		-		-
SP3:							-				-
SP4:
SP5:											-		-

ECgene alternative splicing isoforms for TSPAN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPAN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGACTAGCA

About this image

TSPAN3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Thoracic Rib

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TSPAN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPAN3

SOURCE GeneReport for Unigene cluster: Hs.5062

SABiosciences Custom PCR Arrays for TSPAN3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN3 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TSPAN3 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TSPAN3¹	tetraspanin 3	82.35(n) 90.91(a)		415348 XM_003641844.1 XP_003641892.1
lizard (Anolis carolinensis)	Reptilia	TSPAN3⁶	--	92(a)	1 ↔ 1	GL343374.1(913951-927928)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23773²	Xenopus laevis transcribed sequence with moderate similarity more	79.25(n)		BU914676.1
zebrafish (Danio rerio)	Actinopterygii	tspan3a¹	tetraspanin 3a	76.42(n) 87.35(a)		565579 NM_001025538.2 NP_001020709.1
fruit fly (Drosophila melanogaster)	Insecta	Tsp3A⁶ Tsp86D⁶	Tetraspanin 86D	19(a) 18(a)	possible ortholog possible ortholog	X(2511791-2513771) 3R(6694435-6696277)

ENSEMBL Gene Tree for TSPAN3 (if available)
TreeFam Gene Tree for TSPAN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TSPAN3 gene

CD151² TSPAN1² CD37² TSPAN6² TSPAN9² CD63² CD53² CD82²

TSPAN18² TSPAN7² TSPAN4² TSPAN11² ENSG00000250349² TSPAN8²

13 SIMAP similar genes for TSPAN3 using alignment to 4 protein entries: TSN3_HUMAN (see all proteins):

CD151 TSPAN11 CD63 TSPAN16 TM4SF2 TSPAN9

TSPAN1 TSPAN6 TSPAN8 TSPAN7 TSPAN4 CD53

CD82

TSPAN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11636648^1,2	C,F,H,	--	77335891(+)	`GAAATC/TGCAGA`	3	--	ds500¹		20		NS EA NA WA	2346
rs11636613^1,2	C,F,A,H,	--	77335902(+)	`CAAACA/GCAGAT`	3	--	ds500¹		21		NS EA NA WA CSA	2347
rs143295452^1,2		--	77336078(+)	`GGACAC/TGATGC`	3	--	ds500¹		0	--	--	--	--
rs118012826^1,2	C,F,	--	77336133(+)	`TGGACG/AGAATT`	3	--	ds500¹		1		EA	120
rs181623428^1,2		--	77336222(+)	`GACAGA/GTGTGG`	3	--	ds500¹		0	--	--	--	--
rs116584323^1,2	F,	--	77336268(+)	`GTTGGC/TGCAAG`	3	--	ds500¹		1		WA	118
rs186214149^1,2		--	77336414(+)	`GAAATA/CATTTC`	3	--	ut3¹		0	--	--	--	--
rs114071059^1,2	F,	--	77336664(+)	`GCACTG/AGGTAA`	3	--	ut3¹		1		WA	118
rs191506212^1,2		--	77336795(+)	`TTTCCA/GGGACA`	3	--	ut3¹		0	--	--	--	--
rs114576797^1,2		--	77336949(+)	`GAGGCT/CGCTCT`	3	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for TSPAN3 (77336359 - 77376326 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for TSPAN3
9 CNVs: 77013 4905 87755 35346 77012 87753 3969 49592 35348

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN3

DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TSPAN3 for disorders           About GeneDecksing

OMIM gene information: 613134    OMIM disorders: --

4 diseases for TSPAN3:    About MalaCards

chronic fatigue syndrome echinococcosis prostate cancer prostatitis

1 disease from the University of Copenhagen DISEASES database for TSPAN3:

Echinococcosis

Export disorders for TSPAN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TSPAN3 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TSPAN3)

Utopia: connect your pdf to the dynamic
world of online information

Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Sequences and expression of six new members of the tetraspanin/TM4SF family. (PubMed id 9714763)^{1, 2} Todd S.C.... Levy S. (1998)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10099	HGNC: 17752	AceView: TM4SF8	Ensembl:ENSG00000140391	euGenes: HUgn10099
ECgene: TSPAN3	H-InvDB: TSPAN3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TSPAN3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TSPAN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TSPAN3 gene:
Search GeneIP for patents involving TSPAN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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