Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN3 Gene

Aliases for TSPAN3 Gene

  • Tetraspanin 3 2 3 5
  • Transmembrane 4 Superfamily Member 8 2 3 4
  • Tetraspanin TM4-A 3 4
  • TSPAN-3 3 4
  • TM4SF8 3 4
  • Tetraspan TM4SF 3
  • Tetraspanin-3 3
  • Tetraspan 3 3
  • TM4-A 3

External Ids for TSPAN3 Gene

Previous HGNC Symbols for TSPAN3 Gene

  • TM4SF8

Previous GeneCards Identifiers for TSPAN3 Gene

  • GC15M075126
  • GC15M075127
  • GC15M077336
  • GC15M054093

Summaries for TSPAN3 Gene

Entrez Gene Summary for TSPAN3 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]

GeneCards Summary for TSPAN3 Gene

TSPAN3 (Tetraspanin 3) is a Protein Coding gene. An important paralog of this gene is TSPAN7.

UniProtKB/Swiss-Prot for TSPAN3 Gene

  • Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Gene Wiki entry for TSPAN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN3 Gene

Genomics for TSPAN3 Gene

Regulatory Elements for TSPAN3 Gene

Enhancers for TSPAN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F077106 0.7 Ensembl ENCODE 19.9 -23.6 -23599 1.8 SIX4 BCOR CTCF ZNF146 MAX ZMYM3 ZNF2 RAD21 CHAMP1 ZNF324 TSPAN3 LOC101929457 PIR41987
GH15F077063 0.2 ENCODE 19.1 +16.4 16443 8.5 HDGF PKNOX1 SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP3 NFYC TSPAN3 TYRO3P PSTPIP1 ADAMTS7P3 LOC101929457 ENSG00000269951 ENSG00000278991
GH15F076993 0.7 FANTOM5 ENCODE 16.2 +87.2 87165 7.4 HDGF PKNOX1 ZNF133 MAX RELA ZNF316 GATA2 POLR2A SCRT2 EED SCAPER TSPAN3 ETFA ENSG00000269951 PSTPIP1 LOC105370905
GH15F077526 1.3 Ensembl ENCODE 16.2 -444.7 -444685 5.0 ATF1 ARID4B DMAP1 ZNF2 ZNF121 GLIS2 ELK1 KLF7 ZNF263 SP3 LOC101929457 TSPAN3 PEAK1 LOC105370906
GH15F077000 1.1 Ensembl ENCODE 15.8 +80.7 80662 5.0 HDGF SOX13 CTCF PKNOX1 MAX EBF1 FOSL1 GATA2 SMARCE1 MTA2 SCAPER TSPAN3 RCN2 LOC101929439 PSTPIP1 LOC105370905
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TSPAN3 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001797041 84 601 PKNOX1 ZFP64 ZNF76 GLIS2 ZNF138 ZNF263 ZNF202 ZNF680 ZBTB11 NFYC

Genomic Location for TSPAN3 Gene

77,041,404 bp from pter
77,083,984 bp from pter
42,581 bases
Minus strand

Genomic View for TSPAN3 Gene

Genes around TSPAN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN3 Gene

Proteins for TSPAN3 Gene

  • Protein details for TSPAN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NEH4
    • B3KQQ2
    • B4DP19
    • Q9BW22
    • Q9NVX9

    Protein attributes for TSPAN3 Gene

    253 amino acids
    Molecular mass:
    28018 Da
    Quaternary structure:
    • Interacts with claudin-11/CLDN11 and integrins.

    Alternative splice isoforms for TSPAN3 Gene


neXtProt entry for TSPAN3 Gene

Post-translational modifications for TSPAN3 Gene

  • Ubiquitination at Lys 124
  • Glycosylation at Asn 127, Asn 152, Asn 167, and Asn 183
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSPAN3 Gene

Domains & Families for TSPAN3 Gene

Gene Families for TSPAN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN3: view

Function for TSPAN3 Gene

Molecular function for TSPAN3 Gene

UniProtKB/Swiss-Prot Function:
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.

Gene Ontology (GO) - Molecular Function for TSPAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TSPAN3: view
genes like me logo Genes that share phenotypes with TSPAN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN3

miRNA for TSPAN3 Gene

miRTarBase miRNAs that target TSPAN3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN3 Gene

Localization for TSPAN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN3 Gene COMPARTMENTS Subcellular localization image for TSPAN3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TSPAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TSPAN3: view

Pathways & Interactions for TSPAN3 Gene

SuperPathways for TSPAN3 Gene

No Data Available

Interacting Proteins for TSPAN3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000267970 O60637-TSN3_HUMAN for TSPAN3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TSPAN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TSPAN3: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN3 Gene

Transcripts for TSPAN3 Gene

Unigene Clusters for TSPAN3 Gene

Tetraspanin 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - -
SP3: - -
SP5: - -

Relevant External Links for TSPAN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPAN3 Gene

This gene is overexpressed in Nasal epithelium (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPAN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN3 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN3 Gene:

genes like me logo Genes that share expression patterns with TSPAN3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TSPAN3 Gene

Orthologs for TSPAN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSPAN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN3 34 35
  • 99.74 (n)
(Canis familiaris)
Mammalia TSPAN3 35
  • 94 (a)
(Monodelphis domestica)
Mammalia TSPAN3 35
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN3 35
  • 94 (a)
(Bos Taurus)
Mammalia TSPAN3 34 35
  • 93.28 (n)
(Mus musculus)
Mammalia Tspan3 34 16 35
  • 90.91 (n)
(Rattus norvegicus)
Mammalia Tspan3 34
  • 89.99 (n)
(Gallus gallus)
Aves TSPAN3 34 35
  • 82.06 (n)
(Anolis carolinensis)
Reptilia TSPAN3 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan3 34
  • 76.42 (n)
Str.5967 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23773 34
(Danio rerio)
Actinopterygii tspan3b 35
  • 77 (a)
tspan3a 34 35
  • 76.42 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1062 34
Species where no ortholog for TSPAN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN3 Gene

Gene Tree for TSPAN3 (if available)
Gene Tree for TSPAN3 (if available)

Paralogs for TSPAN3 Gene

(12) SIMAP similar genes for TSPAN3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSPAN3: view

Variants for TSPAN3 Gene

Sequence variations from dbSNP and Humsavar for TSPAN3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10438376 -- 77,059,629(+) TGTAG(C/G)TTTTT intron-variant
rs11072641 -- 77,071,109(-) GAGGC(A/G)CTTGC utr-variant-5-prime
rs111304005 -- 77,055,132(+) ATGAG(A/T)ATGAG intron-variant
rs111308983 -- 77,046,842(+) ATGCA(G/T)AGGTT reference, missense
rs111348419 -- 77,052,853(+) GAGGG(A/G/T)CACTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TSPAN3 Gene

Variant ID Type Subtype PubMed ID
esv2749898 CNV deletion 23290073
esv2760041 CNV gain 17122850
esv3336267 CNV duplication 20981092
esv3552703 CNV deletion 23714750
nsv1040852 CNV gain 25217958
nsv1048833 CNV gain 25217958
nsv1116463 OTHER inversion 24896259
nsv1622 CNV insertion 18451855
nsv509576 CNV insertion 20534489
nsv511547 CNV loss 21212237
nsv517068 CNV gain+loss 19592680
nsv833058 CNV loss 17160897

Variation tolerance for TSPAN3 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN3 Gene

Disorders for TSPAN3 Gene

Relevant External Links for TSPAN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN3 Gene

Publications for TSPAN3 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 3 4 64
  5. Tetraspanins: Spanning from solid tumors to hematologic malignancies. (PMID: 26930362) Yang Y.G. … Kwon H.Y. (Exp. Hematol. 2016) 3 64

Products for TSPAN3 Gene

Sources for TSPAN3 Gene

Loading form....