Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN2 Gene

Aliases for TSPAN2 Gene

  • Tetraspanin 2 2 3 5
  • Tetraspan NET-3 3 4
  • TSPAN-2 3 4
  • Tetraspanin 2 Isoform 3
  • New EST Tetraspan 3 3
  • Tetraspan TM4SF 3
  • Tetraspan 2 3
  • NET3 3
  • TSN2 3

External Ids for TSPAN2 Gene

Previous GeneCards Identifiers for TSPAN2 Gene

  • GC01M115303
  • GC01M115590
  • GC01M113448

Summaries for TSPAN2 Gene

Entrez Gene Summary for TSPAN2 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for TSPAN2 Gene

TSPAN2 (Tetraspanin 2) is a Protein Coding gene. Diseases associated with TSPAN2 include migraine with or without aura 1. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for TSPAN2 Gene

  • May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

Gene Wiki entry for TSPAN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN2 Gene

Genomics for TSPAN2 Gene

Regulatory Elements for TSPAN2 Gene

Promoters for TSPAN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN2 Gene

Chromosome:
1
Start:
115,048,011 bp from pter
End:
115,089,500 bp from pter
Size:
41,490 bases
Orientation:
Minus strand

Genomic View for TSPAN2 Gene

Genes around TSPAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN2 Gene

Proteins for TSPAN2 Gene

  • Protein details for TSPAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60636-TSN2_HUMAN
    Recommended name:
    Tetraspanin-2
    Protein Accession:
    O60636
    Secondary Accessions:
    • D6PTH4
    • Q5TET2
    • Q8WU05

    Protein attributes for TSPAN2 Gene

    Size:
    221 amino acids
    Molecular mass:
    24148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN2 Gene

Proteomics data for TSPAN2 Gene at MOPED

Post-translational modifications for TSPAN2 Gene

  • Glycosylation at Asn 139
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN2 Gene

No data available for DME Specific Peptides for TSPAN2 Gene

Domains & Families for TSPAN2 Gene

Gene Families for TSPAN2 Gene

Suggested Antigen Peptide Sequences for TSPAN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60636

UniProtKB/Swiss-Prot:

TSN2_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN2: view

Function for TSPAN2 Gene

Molecular function for TSPAN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
genes like me logo Genes that share phenotypes with TSPAN2: view

Animal Models for TSPAN2 Gene

MGI Knock Outs for TSPAN2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN2 Gene

Localization for TSPAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN2 Gene COMPARTMENTS Subcellular localization image for TSPAN2 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IEA,TAS 9714763
genes like me logo Genes that share ontologies with TSPAN2: view

Pathways & Interactions for TSPAN2 Gene

SuperPathways for TSPAN2 Gene

No Data Available

Interacting Proteins for TSPAN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000358529%0d%0a9606.ENSP00000306245%0d%0a
Selected Interacting proteins: ENSP00000358529 O60636-TSN2_HUMAN for TSPAN2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TSPAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007420 brain development IEA --
GO:0014005 microglia development IEA --
GO:0042552 myelination IEA --
genes like me logo Genes that share ontologies with TSPAN2: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN2 Gene

Drugs & Compounds for TSPAN2 Gene

No Compound Related Data Available

Transcripts for TSPAN2 Gene

Unigene Clusters for TSPAN2 Gene

Tetraspanin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -

Relevant External Links for TSPAN2 Gene

GeneLoc Exon Structure for
TSPAN2
ECgene alternative splicing isoforms for
TSPAN2

Expression for TSPAN2 Gene

mRNA expression in normal human tissues for TSPAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN2 Gene

This gene is overexpressed in Colon - Sigmoid (x5.5), Whole Blood (x5.0), Artery - Tibial (x4.4), and Uterus (x4.3).

Protein differential expression in normal tissues from HIPED for TSPAN2 Gene

This gene is overexpressed in Colon (16.6), Fetal Brain (12.6), Platelet (8.6), Peripheral blood mononuclear cells (7.2), and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN2 Gene



SOURCE GeneReport for Unigene cluster for TSPAN2 Gene Hs.310458

genes like me logo Genes that share expression patterns with TSPAN2: view

Protein tissue co-expression partners for TSPAN2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN2 Gene

Orthologs for TSPAN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN2 35
  • 99.24 (n)
  • 99.09 (a)
TSPAN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN2 36
  • 82 (a)
OneToOne
TSPAN2 35
  • 90.55 (n)
  • 93.53 (a)
dog
(Canis familiaris)
Mammalia TSPAN2 35
  • 91.25 (n)
  • 95.02 (a)
TSPAN2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan2 16
Tspan2 35
  • 88.84 (n)
  • 93.67 (a)
Tspan2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSPAN2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan2 35
  • 88.99 (n)
  • 94.57 (a)
chicken
(Gallus gallus)
Aves TSPAN2 35
  • 69.23 (n)
  • 64.25 (a)
TSPAN2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN2 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12918 35
tspan2 35
  • 62.73 (n)
  • 56.36 (a)
zebrafish
(Danio rerio)
Actinopterygii tspan2 36
  • 55 (a)
OneToMany
TSPAN2 (2 of 2) 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-9 36
  • 26 (a)
OneToMany
Species with no ortholog for TSPAN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN2 Gene

ENSEMBL:
Gene Tree for TSPAN2 (if available)
TreeFam:
Gene Tree for TSPAN2 (if available)

Paralogs for TSPAN2 Gene

Paralogs for TSPAN2 Gene

(12) SIMAP similar genes for TSPAN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN2: view

Variants for TSPAN2 Gene

Sequence variations from dbSNP and Humsavar for TSPAN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9659602 - 115,058,974(+) CATGT(A/C/T)GGATA reference, missense
rs717275 -- 115,067,470(+) AATGC(C/T)CTGGA intron-variant
rs717276 -- 115,067,770(+) TGGAG(A/T)AAACC intron-variant
rs747529 -- 115,072,055(+) CACCT(C/T)TAATG intron-variant
rs747530 -- 115,072,119(+) ATGAG(A/G)AAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN2 Gene

Variant ID Type Subtype PubMed ID
nsv528883 CNV Loss 19592680
esv26121 CNV Loss 19812545
nsv463295 CNV Loss 19166990
nsv872165 CNV Loss 21882294

Variation tolerance for TSPAN2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN2 Gene

HapMap Linkage Disequilibrium report
TSPAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN2 Gene

Disorders for TSPAN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPAN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN2

Genetic Association Database (GAD)
TSPAN2
Human Genome Epidemiology (HuGE) Navigator
TSPAN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN2
genes like me logo Genes that share disorders with TSPAN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN2 Gene

Publications for TSPAN2 Gene

  1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 2 3 4 67
  2. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F. (J. Cell. Sci. 2001) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. TSPAN2 is involved in cell invasion and motility during lung cancer progression. (PMID: 24726368) Otsubo C. … Enari M. (Cell Rep 2014) 3
  5. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3

Products for TSPAN2 Gene

Sources for TSPAN2 Gene

Back to Top

Content