Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN19 Gene

Aliases for TSPAN19 Gene

  • Tetraspanin 19 2 3 5
  • Tspan-19 3 4
  • Putative Tetraspanin-19 3

External Ids for TSPAN19 Gene

Previous GeneCards Identifiers for TSPAN19 Gene

  • GC12M083911
  • GC12M085408
  • GC12M082465

Summaries for TSPAN19 Gene

GeneCards Summary for TSPAN19 Gene

TSPAN19 (Tetraspanin 19) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN19 Gene

Genomics for TSPAN19 Gene

Regulatory Elements for TSPAN19 Gene

Enhancers for TSPAN19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F085026 0.3 FANTOM5 0.4 +9.8 9837 0.1 TSPAN19 GC12P084970
GH12F085015 0.2 ENCODE 0.3 +19.6 19615 2.0 SOX13 GTF2F1 TBP TAF1 JUN MAX BRCA1 ZKSCAN1 RCOR1 FOS TSPAN19 GC12P084970
GH12F085007 0.2 ENCODE 0.3 +28.3 28302 0.2 TSPAN19 GC12P084970
GH12F084996 0.5 ENCODE 0.3 +39.3 39282 1.0 GC12P084970 TSPAN19
GH12F085004 0.4 ENCODE 0.3 +31.2 31156 1.7 SMARCA4 POLR2A GC12P084970 TSPAN19
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TSPAN19 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001779325 -123 1199 TBP PKNOX1 SIN3A BMI1 RFX5 YY1 ZNF366 SCRT2 RCOR1 SMARCC1

Genomic Location for TSPAN19 Gene

Chromosome:
12
Start:
85,014,311 bp from pter
End:
85,036,278 bp from pter
Size:
21,968 bases
Orientation:
Minus strand

Genomic View for TSPAN19 Gene

Genes around TSPAN19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN19 Gene

Proteins for TSPAN19 Gene

  • Protein details for TSPAN19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C672-TSN19_HUMAN
    Recommended name:
    Putative tetraspanin-19
    Protein Accession:
    P0C672

    Protein attributes for TSPAN19 Gene

    Size:
    248 amino acids
    Molecular mass:
    28460 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN19 Gene

Post-translational modifications for TSPAN19 Gene

  • Glycosylation at Asn 5 and Asn 158
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSPAN19 Gene

Domains & Families for TSPAN19 Gene

Gene Families for TSPAN19 Gene

Protein Domains for TSPAN19 Gene

Suggested Antigen Peptide Sequences for TSPAN19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C672

UniProtKB/Swiss-Prot:

TSN19_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN19: view

Function for TSPAN19 Gene

Animal Model Products

miRNA for TSPAN19 Gene

miRTarBase miRNAs that target TSPAN19

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN19 Gene

Localization for TSPAN19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN19 Gene COMPARTMENTS Subcellular localization image for TSPAN19 gene
Compartment Confidence
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPAN19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN19: view

Pathways & Interactions for TSPAN19 Gene

SuperPathways for TSPAN19 Gene

No Data Available

Interacting Proteins for TSPAN19 Gene

Gene Ontology (GO) - Biological Process for TSPAN19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN19: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN19 Gene

Transcripts for TSPAN19 Gene

Unigene Clusters for TSPAN19 Gene

Tetraspanin 19:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN19 Gene

No ASD Table

Relevant External Links for TSPAN19 Gene

GeneLoc Exon Structure for
TSPAN19
ECgene alternative splicing isoforms for
TSPAN19

Expression for TSPAN19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN19 Gene

mRNA differential expression in normal tissues according to GTEx for TSPAN19 Gene

This gene is overexpressed in Pituitary (x6.4), Testis (x5.8), Brain - Hypothalamus (x5.1), and Lung (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of TSPAN19 Gene:

TSPAN19

SOURCE GeneReport for Unigene cluster for TSPAN19 Gene:

Hs.156962
genes like me logo Genes that share expression patterns with TSPAN19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TSPAN19 Gene

Orthologs for TSPAN19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSPAN19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN19 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia TSPAN19 34 35
  • 86.29 (n)
cow
(Bos Taurus)
Mammalia TSPAN19 34 35
  • 84.75 (n)
chicken
(Gallus gallus)
Aves TSPAN19 34 35
  • 60.62 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884436 34
  • 45.76 (n)
TSPAN19 35
  • 17 (a)
OneToOne
Species where no ortholog for TSPAN19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN19 Gene

ENSEMBL:
Gene Tree for TSPAN19 (if available)
TreeFam:
Gene Tree for TSPAN19 (if available)

Paralogs for TSPAN19 Gene

(3) SIMAP similar genes for TSPAN19 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSPAN19: view

No data available for Paralogs for TSPAN19 Gene

Variants for TSPAN19 Gene

Sequence variations from dbSNP and Humsavar for TSPAN19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10506910 -- 85,033,913(+) GTTAT(A/G)TCATA intron-variant
rs10549033 -- 85,015,542(+) CATAT(-/AC)ACACA intron-variant, downstream-variant-500B
rs10862952 -- 85,025,049(+) ATTTA(C/G)ATGTT intron-variant
rs11116686 -- 85,015,046(+) ATGAT(A/G)TTAAT intron-variant
rs11116687 -- 85,019,202(+) CTTTA(C/T)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN19 Gene

Variant ID Type Subtype PubMed ID
esv3630228 CNV gain 21293372
esv3630229 CNV gain 21293372
nsv1040452 CNV gain 25217958
nsv1145614 CNV deletion 24896259
nsv510605 CNV deletion 20534489
nsv559653 CNV loss 21841781

Variation tolerance for TSPAN19 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN19 Gene

Disorders for TSPAN19 Gene

Relevant External Links for TSPAN19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN19

No disorders were found for TSPAN19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN19 Gene

Publications for TSPAN19 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  2. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. (PMID: 18795891) Protty M.B. … Tomlinson M.G. (Biochem. J. 2009) 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for TSPAN19 Gene

Sources for TSPAN19 Gene

Content
Loading form....