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TSPAN19 Gene

protein-coding   GIFtS: 35
GCID: GC12M085408

Tetraspanin 19

  Search for TSPAN19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Tetraspanin 191 2
Putative Tetraspanin-192
tspan-192
Tspan-193

External Ids:    HGNC: 318861   Entrez Gene: 1444482   Ensembl: ENSG000002317387   UniProtKB: P0C6723   
ORGUL members:    fRNAdb10:FR241205      
H-InvDB12:HIT000046198    
NCBI13:AK126325    

Export aliases for TSPAN19 gene to outside databases

Previous GC identifers: GC12M083911 GC12M082465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSPAN19 Gene:
TSPAN19 (tetraspanin 19) is a protein-coding gene.

fRNAdb sequence ontology for TSPAN19:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN19 gene promoter:
         Max1   Nkx2-2   POU3F2 (N-Oct-5a)   POU6F1 (c2)   POU3F2   C/EBPalpha   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TSPAN19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.31   Ensembl cytogenetic band:  12q21.31   HGNC cytogenetic band: 12q21.31

TSPAN19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN19 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M085408:  view genomic region     (about GC identifiers)

Start:
85,408,094 bp from pter      End:
85,430,055 bp from pter
Size:
21,962 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSN19_HUMAN, P0C672 (See protein sequence)
Recommended Name: Putative tetraspanin-19  
Size: 248 amino acids; 28460 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for TSPAN19: NX_P0C672

Explore proteomics data for TSPAN19 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn158

  • See TSPAN19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001094387.1  
    ENSEMBL proteins: 
     ENSP00000440661   ENSP00000433816   ENSP00000408184   ENSP00000449663   ENSP00000446898  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    3 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2

    Graphical View of Domain Structure for InterPro Entry P0C672

    ProtoNet protein and cluster: P0C672

    UniProtKB/Swiss-Prot: TSN19_HUMAN, P0C672
    Similarity: Belongs to the tetraspanin (TM4SF) family


    TSPAN19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPAN19
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN19_HUMAN, P0C672: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TSPAN19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN19
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN19

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN19 (TSN19)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSPAN19 gene: 
    NM_001100917.1  

    Unigene Cluster for TSPAN19:

    Tetraspanin 19
    Hs.156962  [show with all ESTs]
    Unigene Representative Sequence: AK126325
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525452 ENST00000529820 ENST00000532498(uc009zsj.3) ENST00000532628
    ENST00000433494 ENST00000547403 ENST00000552392 ENST00000547836
    miRNA
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    Additional mRNA sequence: AK126325.1 

    5 DOTS entries:

    DT.40126155  DT.91655690  DT.100749560  DT.100749561  DT.97835583 

    22 AceView cDNA sequences:

    BM703409 AK126325 AA884596 BU679234 CB852874 CB852420 BM975716 BX116902 
    BG485563 CB854430 BU676582 BU729341 BI771739 BG212770 BG182158 BG221062 
    BE972597 BG218616 BG213857 CD689791 BG208066 BG187896 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTATAAA
    TSPAN19 Expression
    About this image

    TSPAN19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156962
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TSPAN19 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia TSPAN191 tetraspanin 19 86.29(n)
    77.42(a)
      100685354  XM_005629196.1  XP_005629253.1 
    chicken
    (Gallus gallus)
    Aves TSPAN191 tetraspanin 19 60.62(n)
    43.88(a)
      100859115  XM_003640358.2  XP_003640406.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018844361 CD82 antigen-like 45.76(n)
    27.54(a)
      101884436  XM_005164597.1  XP_005164654.1 


    ENSEMBL Gene Tree for TSPAN19 (if available)
    TreeFam Gene Tree for TSPAN19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN19 gene
    3 SIMAP similar genes for TSPAN19 using alignment to 5 protein entries:     TSN19_HUMAN (see all proteins):
    COQ5    CD82    CD63

    TSPAN19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN19 (see all 320)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829799791,2
    --85407596(+) ACCTAA/GAGAAG 1 -- int10--------
    rs1382709171,2
    C--85407608(+) TTTCAC/TTGAGG 1 -- int10--------
    rs1114257471,2
    C--85407656(+) AAAGTC/TCATAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1120270101,2
    C,F--85407658(+) AGTCCG/ATAAGT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1869467701,2
    --85407895(+) GTTTTC/GTTAAG 1 -- int10--------
    rs1915347301,2
    --85407921(+) GTACAC/TGATAT 1 -- int10--------
    rs619300421,2
    F--85407925(+) ATGATG/ATGATT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1865003851,2
    --85408060(+) CTGAAC/TGGTAG 1 -- int10--------
    rs38351461,2
    C--85408489(+) TTGTG-/AATAGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1924863021,2
    --85408575(+) TTTAGA/GTTTTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TSPAN19 (85408094 - 85430055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TSPAN19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899388CNV Loss21882294
    nsv899387CNV Loss21882294
    nsv510605CNV Loss20534489
    nsv899377CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN19 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TSPAN19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    4. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. (PubMed id 18795891)9 Protty M.B.... Tomlinson M.G. (Biochem. J. 2009)
    5. (PubMed id 15103394)10 
    6. (PubMed id 17451645)10 
    7. (PubMed id 18089548)10 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144448 HGNC: 31886 AceView: LOC144448 Ensembl:ENSG00000231738 euGenes: HUgn144448
    ECgene: TSPAN19 H-InvDB: TSPAN19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPAN19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPAN19 gene:
    Search GeneIP for patents involving TSPAN19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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