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TSPAN18 Gene

protein-coding   GIFtS: 47
GCID: GC11P044838

Tetraspanin 18

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetraspanin 181 2
TSPAN2
tetraspanin-182
tspan-182
Tspan-183

External Ids:    HGNC: 206601   Entrez Gene: 901392   Ensembl: ENSG000001575707   UniProtKB: Q96SJ83   

Export aliases for TSPAN18 gene to outside databases

Previous GC identifer: GC11P044496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSPAN18 Gene:
TSPAN18 (tetraspanin 18) is a protein-coding gene. Diseases associated with TSPAN18 include schizophrenia, and endotheliitis. An important paralog of this gene is TSPAN2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN18 gene promoter:
         Egr-3   NF-1   AML1a   Egr-1   POU3F2   Egr-4   Chx10   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN18 promoter sequence
   Search Chromatin IP Primers for TSPAN18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

TSPAN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN18 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044838:  view genomic region     (about GC identifiers)

Start:
44,748,015 bp from pter      End:
44,953,978 bp from pter
Size:
205,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSN18_HUMAN, Q96SJ8 (See protein sequence)
Recommended Name: Tetraspanin-18  
Size: 248 amino acids; 27710 Da
Sequence caution: Sequence=BAC11690.1; Type=Erroneous initiation;
Secondary accessions: Q6UY44 Q8NBI9

Explore the universe of human proteins at neXtProt for TSPAN18: NX_Q96SJ8

Explore proteomics data for TSPAN18 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn111, Asn129

  • See TSPAN18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_570139.3  
    ENSEMBL proteins: 
     ENSP00000433592   ENSP00000434625   ENSP00000433362   ENSP00000429993   ENSP00000427942  
     ENSP00000430343   ENSP00000429020   ENSP00000339820  

    TSPAN18 Human Recombinant Protein Products:

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    Novus Biologicals TSPAN18 Lysates
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    Cloud-Clone Corp. Proteins for TSPAN18

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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for TSPAN18 at Abcam
    Cloud-Clone Corp. Antibodies for TSPAN18
    Search ThermoFisher Antibodies for TSPAN18
    LSBio Antibodies in human, mouse, rat for TSPAN18

    TSPAN18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TSPAN18
    Cloud-Clone Corp. CLIAs for TSPAN18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry Q96SJ8

    ProtoNet protein and cluster: Q96SJ8

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN18_HUMAN, Q96SJ8
    Similarity: Belongs to the tetraspanin (TM4SF) family


    TSPAN18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 MGI phenotypic allele for Tspan18 (no phenotypes)

    TSPAN18 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tspan18tm1Lex for TSPAN18

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPAN18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSPAN18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPAN18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPAN18

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSPAN18:
    hsa-mir-597-5p (MIRT040497), hsa-mir-92a-3p (MIRT049631)

    Block miRNA regulation of human, mouse, rat TSPAN18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN18 (see all 57):
    hsa-miR-579 hsa-let-7d hsa-miR-330-5p hsa-miR-765 hsa-miR-301a hsa-miR-449a hsa-let-7g hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSPAN18
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSPAN18

    Clone
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    OriGene clones in human, mouse for TSPAN18 (see all 11)
    OriGene ORF clones in mouse, rat for TSPAN18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN18 (NM_130783)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSPAN18
    ESI BIO PureStem Progenitors for TSPAN18: 
    PureStem MEL2, NCr-fac Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN18_HUMAN, Q96SJ8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TSPAN18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN18
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN18

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN18 (TSN18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSPAN18 gene (2 alternative transcripts): 
    NM_001031730.1  NM_130783.4  

    Unigene Cluster for TSPAN18:

    Tetraspanin 18
    Hs.385634  [show with all ESTs]
    Unigene Representative Sequence: NM_130783
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533786 ENST00000533202 ENST00000533080 ENST00000520358 ENST00000520999
    ENST00000520837 ENST00000518429(uc001myg.3) ENST00000519051 ENST00000520245
    ENST00000517621 ENST00000521990 ENST00000520278 ENST00000340160(uc001mye.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSPAN18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN18 (see all 57):
    hsa-miR-579 hsa-let-7d hsa-miR-330-5p hsa-miR-765 hsa-miR-301a hsa-miR-449a hsa-let-7g hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSPAN18
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN18
    Clone
    Products:
         
    OriGene clones in human, mouse for TSPAN18 (see all 11)
    OriGene ORF clones in mouse, rat for TSPAN18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN18 (NM_130783)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSPAN18
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN18
      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN18
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN18

    Additional mRNA sequence: 

    AK027515.1 AK027715.1 AK075547.1 AY358087.1 BC019342.2 

    20 DOTS entries:

    DT.95167083  DT.100757525  DT.91667654  DT.100801564  DT.120709731  DT.120709677  DT.120709695  DT.120709733 
    DT.120709739  DT.447356  DT.91753527  DT.95167093  DT.100642756  DT.120709743  DT.91989708  DT.95167088 
    DT.100649893  DT.120709774  DT.120709777  DT.91917603 

    Selected AceView cDNA sequences (see all 170):

    BM672270 BP334243 BE296419 BM700925 AI146822 CR597335 BF438041 AA227614 
    AA326605 BE326377 T34493 BF222231 BE269763 BX416503 AI632087 AI160268 
    AI215915 BM726565 BF437556 Z42871 AW205519 AI051716 BQ006406 BF222454 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCATATGT
    TSPAN18 Expression
    About this image


    TSPAN18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
    TSPAN18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.385634
        Custom PCR Arrays for TSPAN18
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN18 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan181 , 5 tetraspanin 181, 5 87.1(n)1
    90.73(a)1
      2 (51.37 cM)5
    2415561  NM_183180.21  NP_899003.11 
     932017605 
    chicken
    (Gallus gallus)
    Aves TSPAN181 tetraspanin 18 76.25(n)
    81.38(a)
      395586  NM_204801.1  NP_990132.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSPAN186
    tetraspanin 18
    83(a)
    1 ↔ 1
    1(46505508-46533679)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985862 similar to tetraspanin similiar to uroplakin 1 75.14(n)    BC049346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tspan18b1 tetraspanin 18b 73.44(n)
    72.76(a)
      436712  NM_001002439.1  NP_001002439.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp66E6
    Tetraspanin 66E
    27(a)
    1 → many
    3L(8905599-8925165)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-116
    tsp-136
    Protein TSP-13 (tsp-13) mRNA, complete cds
    20(a)
    15(a)
    many ↔ many
    many ↔ many
    X(9163164-9166007) WBGene00006637
    V(19154106-19157705) WBGene00006639


    ENSEMBL Gene Tree for TSPAN18 (if available)
    TreeFam Gene Tree for TSPAN18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN18 gene
    TSPAN22  CD92  TSPAN12  CD372  TSPAN92  CD532  CD822  CD812  
    TSPAN42  TSPAN82  
    Selected SIMAP similar genes for TSPAN18 using alignment to 8 protein entries:     TSN18_HUMAN (see all proteins) (see all similar genes):
    CD82    BTCC-1    CD53    CD151    CD9    TSPAN5
    TSPAN4    TSPAN1    TSPAN11    TSPAN16    CD37    TSPAN8
    CD63    TSPAN6    TSPAN17    TSPAN9    TM4SF2    TSPAN7

    TSPAN18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN18 (see all 3551)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144139771,2
    F--44783992(+) ATACAC/TGTATT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1407073421,2
    C--44784044(+) GTTTGC/TAGTGG 1 -- us2k10--------
    rs1839789771,2
    C--44784153(+) TACCTA/CTATAT 1 -- us2k10--------
    rs1434854281,2
    C--44784166(+) ACATA-/TGTGTGT 1 -- us2k10--------
    rs1883123081,2
    --44784254(+) GGTTCA/GTGATG 1 -- us2k10--------
    rs1459091001,2
    C--44784319(+) CTAAAC/TAAAAT 1 -- us2k10--------
    rs1807798371,2
    --44784345(+) AGCCAA/GTCCCT 1 -- us2k10--------
    rs1863796941,2
    C--44784432(+) GACCTC/TGAACT 1 -- us2k10--------
    rs1382105891,2
    --44784477(+) GGCGAA/GCGTGA 1 -- us2k10--------
    rs71048961,2
    C,F,A,H--44784540(+) GCACCA/GGGCTT 1 -- us2k126Minor allele frequency- G:0.47EA NA NS WA CSA 2567

    HapMap Linkage Disequilibrium report for TSPAN18 (44748015 - 44953978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TSPAN18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744420CNV Deletion23290073
    nsv510252CNV Loss20534489
    nsv832140CNV Loss17160897
    nsv304CNV Loss18451855
    esv28960CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPAN18
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TSPAN18:    
    About MalaCards
    schizophrenia    endotheliitis


    TSPAN18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSPAN18
    Human Genome Epidemiology (HuGE) Navigator: TSPAN18 (2 documents)

    Export disorders for TSPAN18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN18 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with TSPAN18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PubMed id 22037552)1, 4 Yue W.H....Zhang D. (Nat. Genet. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Specific tetraspanin functions. (PubMed id 11756464)1, 3 Hemler M.E. (J. Cell Biol. 2001)
    7. Replication study confirms link between TSPAN18 mutation and schizophrenia in Han Chinese. (PubMed id 23505562)1 Yuan J....Shugart Y.Y. (PLoS ONE 2013)
    8. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (J Drug Target 2012)
    9. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (Blood 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90139 HGNC: 20660 AceView: LOC90139 Ensembl:ENSG00000157570 euGenes: HUgn90139
    ECgene: TSPAN18 H-InvDB: TSPAN18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPAN18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPAN18 gene:
    Search GeneIP for patents involving TSPAN18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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