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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPAN18 Gene

protein-coding   GIFtS: 44
GCID: GC11P044838

tetraspanin 18

 Explore 2 diseases affiliated with
TSPAN18 via our new
 Human Malady Compendium 
Biological research products
for TSPAN18
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tetraspanin 181 2
TSPAN1 2
Tetraspanin-181
Tspan-183
Tspan-183

External Ids:    HGNC: 206601   Entrez Gene: 901392   Ensembl: ENSG000001575707   UniProtKB: Q96SJ83   

Export aliases for TSPAN18 gene to outside databases

Previous GC identifer: GC11P044496


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPAN18 gene promoter:
         Egr-3   NF-1   AML1a   Egr-1   POU3F2   Egr-4   Chx10   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN18 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPAN18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

TSPAN18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN18 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044838:  view genomic region     (about GC identifiers)

Start:
44,748,015 bp from pter      End:
44,953,978 bp from pter
Size:
205,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSN18_HUMAN, Q96SJ8 (See protein sequence)
Recommended Name: Tetraspanin-18  
Size: 248 amino acids; 27710 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC11690.1; Type=Erroneous initiation;
Secondary accessions: Q6UY44 Q8NBI9

Explore the universe of human proteins at neXtProt for TSPAN18: NX_Q96SJ8

TSPAN18 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_570139.3  
ENSEMBL proteins: 
 ENSP00000433592   ENSP00000434625   ENSP00000433362   ENSP00000429993   ENSP00000427942  
 ENSP00000430343   ENSP00000429020   ENSP00000339820  

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Uscn Proteins for TSPAN18

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--


TSPAN18 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TSPAN18 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR018499 Tetraspanin/Peripherin
 IPR018503 Tetraspanin_CS
 IPR000301 Tetraspanin
 IPR008952 Tetraspanin_EC2

Graphical View of Domain Structure for InterPro Entry Q96SJ8

ProtoNet protein and cluster: Q96SJ8

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: TSN18_HUMAN, Q96SJ8
Similarity: Belongs to the tetraspanin (TM4SF) family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN18 (see all 57):
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SwitchGear 3'UTR luciferase reporter plasmidTSPAN18 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN18

Animal Models:
     Mouse knock-out Tspan18tm1Lex for TSPAN18
     1 MGI phenotypic allele for Tspan18 (no phenotypes)

TSPAN18 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN18

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSPAN18
Search CenterWatch for drugs/clinical trials and news about TSPAN18 / TSN18 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPAN18 gene (2 alternative transcripts): 
NM_001031730.1  NM_130783.4  

Unigene Cluster for TSPAN18:

Tetraspanin 18
Hs.385634  [show with all ESTs]
Unigene Representative Sequence: NM_130783
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000533786 ENST00000533202 ENST00000533080 ENST00000520358 ENST00000520999
ENST00000520837 ENST00000518429(uc001myg.3) ENST00000519051 ENST00000520245
ENST00000517621 ENST00000521990 ENST00000520278 ENST00000340160(uc001mye.4)


miRNA
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hsa-miR-579 hsa-let-7d hsa-miR-330-5p hsa-miR-765 hsa-miR-301a hsa-miR-449a hsa-let-7g hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmidTSPAN18 3' UTR sequence
Inhib. RNA
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Additional cDNA sequence: 

AK027515.1 AK027715.1 AK075547.1 AY358087.1 BC019342.2 

20 DOTS entries:

DT.95167083  DT.100757525  DT.91667654  DT.100801564  DT.120709731  DT.120709677  DT.120709695  DT.120709733 
DT.120709739  DT.447356  DT.91753527  DT.100642756  DT.120709743  DT.91989708  DT.95167088  DT.95167093 
DT.100649893  DT.120709774  DT.120709777  DT.91917603 

24/170 AceView cDNA sequences (see all 170):

CR597335 BF222454 AI343458 T34493 AI215915 BM672270 BQ006406 AI051716 
BF437556 BP334243 BM700925 AI146822 BE296419 BX416503 AI632087 BE269763 
AI160268 BF222231 BM726565 Z42871 AW205519 AA227614 AA326605 BF438041 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPAN18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCATATGT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

TSPAN18 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
AdiposeInterscapular Brown Adipose DepotAdipose
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 9 LifeMap Cells 
NameCategory
PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
PureStem™ progenitor E68 (Embryonic Progenitor Cell)
PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage

Genevestigator expression for TSPAN18

SOURCE GeneReport for Unigene cluster: Hs.385634
    SABiosciences Custom PCR Arrays for TSPAN18
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TSPAN18 gene from 5/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves TSPAN181 tetraspanin 18 76.25(n)
81.38(a)
  395586  NM_204801.1  NP_990132.1 
lizard
(Anolis carolinensis)
Reptilia TSPAN186
--
83(a)
1 ↔ 1
1(46505521-46533679)
African clawed frog
(Xenopus laevis)
Amphibia LOC3985862 similar to tetraspanin similiar to uroplakin 1 75.14(n)    BC049346.1 
zebrafish
(Danio rerio)
Actinopterygii tspan18b1 tetraspanin 18b 73.44(n)
72.76(a)
  436712  NM_001002439.1  NP_001002439.1 
worm
(Caenorhabditis elegans)
Secernentea tsp-116
TetraSPanin family member (tsp-11)
18(a)
1 → many
X(9163107-9165950)


ENSEMBL Gene Tree for TSPAN18 (if available)
TreeFam Gene Tree for TSPAN18 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TSPAN18 gene
CD1512  TSPAN12  CD372  TSPAN62  TSPAN92  TSPAN32  CD632  CD532  
CD822  TSPAN72  TSPAN42  TSPAN112  ENSG000002503492  TSPAN82  
18/22 SIMAP similar genes for TSPAN18 using alignment to 8 protein entries:     TSN18_HUMAN (see all proteins) (see all similar genes):
CD82    BTCC-1    CD53    CD151    CD9    TSPAN5
TSPAN4    TSPAN1    TSPAN11    TSPAN16    CD37    TSPAN8
CD63    TSPAN6    TSPAN17    TSPAN9    TM4SF2    TSPAN7

TSPAN18 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/3092 NCBI SNPs in TSPAN18 are shown (see all 3092    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1144139771,2
F,--44783992(+) ATACAC/TGTATT 1 -- us2k11Minor allele frequency- T:0.02WA 118
rs1407073421,2
--44784044(+) GTTTGC/TAGTGG 1 -- us2k10--------
rs1839789771,2
--44784153(+) TACCTA/CTATAT 1 -- us2k10--------
rs1434854281,2
C,--44784166(+) ACATA-/TGTGTGT 1 -- us2k10--------
rs1883123081,2
--44784254(+) GGTTCA/GTGATG 1 -- us2k10--------
rs1459091001,2
--44784319(+) CTAAAC/TAAAAT 1 -- us2k10--------
rs1807798371,2
--44784345(+) AGCCAA/GTCCCT 1 -- us2k10--------
rs1863796941,2
--44784432(+) GACCTC/TGAACT 1 -- us2k10--------
rs1382105891,2
--44784477(+) GGCGAA/GCGTGA 1 -- us2k10--------
rs71048961,2
C,F,A,H,--44784540(+) GCACCA/GGGCTT 1 -- us2k126Minor allele frequency- G:0.47EA NA NS WA CSA 2567

HapMap Linkage Disequilibrium report for TSPAN18 (44748015 - 44953978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TSPAN18
     1 CNV: 71317

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TSPAN18 for disorders           About GeneDecksing

2 diseases for TSPAN18:    About MalaCards
prostatitis    schizophrenia

Human Genome Epidemiology (HuGE) Navigator: TSPAN18 (2 documents)

Export disorders for TSPAN18 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TSPAN18 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TSPAN18)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  3. Specific tetraspanin functions. (PubMed id 11756464)1, 3 Hemler M.E. (2001)
  4. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)
  5. Genome-wide association study identifies a susceptibi lity locus for schizophrenia in Han Chinese at 11p11.2. (PubMed id 22037552)1 Yue W.H....Zhang D. (2011)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  7. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
  8. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  10. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 90139 HGNC: 20660 AceView: LOC90139 Ensembl:ENSG00000157570 euGenes: HUgn90139
ECgene: TSPAN18 H-InvDB: TSPAN18

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TSPAN18 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TSPAN18 gene:
Search GeneIP for patents involving TSPAN18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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 TSPAN18 Proteins, Antibodies, CLIAs, and ELISAs
 Cell Lines associated with TSPAN18: PureStem MEL2, NCr-fac Progenitor,
PureStem SK11, NCr-fac & Meso-prx Progenitor
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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