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Aliases for TSPAN18 Gene

Aliases for TSPAN18 Gene

  • Tetraspanin 18 2 3
  • Tspan-18 3 4
  • Tetraspanin-18 3
  • TSPAN 3

External Ids for TSPAN18 Gene

Previous GeneCards Identifiers for TSPAN18 Gene

  • GC11P044838
  • GC11P044496

Summaries for TSPAN18 Gene

GeneCards Summary for TSPAN18 Gene

TSPAN18 (Tetraspanin 18) is a Protein Coding gene. An important paralog of this gene is TSPAN9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN18 Gene

Genomics for TSPAN18 Gene

Regulatory Elements for TSPAN18 Gene

Genomic Location for TSPAN18 Gene

44,726,465 bp from pter
44,932,427 bp from pter
205,963 bases
Plus strand

Genomic View for TSPAN18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN18 Gene

Proteins for TSPAN18 Gene

  • Protein details for TSPAN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UY44
    • Q8NBI9

    Protein attributes for TSPAN18 Gene

    248 amino acids
    Molecular mass:
    27710 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11690.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPAN18 Gene

Proteomics data for TSPAN18 Gene at MOPED

Post-translational modifications for TSPAN18 Gene

  • Glycosylation at Asn111 and Asn129

No data available for DME Specific Peptides for TSPAN18 Gene

Domains for TSPAN18 Gene

Gene Families for TSPAN18 Gene


Suggested Antigen Peptide Sequences for TSPAN18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96SJ8
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN18: view

Function for TSPAN18 Gene

Animal Model Products

CRISPR Products

miRNA for TSPAN18 Gene

miRTarBase miRNAs that target TSPAN18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN18

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSPAN18 Gene

Localization for TSPAN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN18 Gene COMPARTMENTS Subcellular localization image for TSPAN18 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TSPAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN18: view

Pathways for TSPAN18 Gene

SuperPathways for TSPAN18 Gene

No Data Available

Interacting Proteins for TSPAN18 Gene

Gene Ontology (GO) - Biological Process for TSPAN18 Gene


No data available for Pathways by source for TSPAN18 Gene

Transcripts for TSPAN18 Gene

Unigene Clusters for TSPAN18 Gene

Tetraspanin 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN18 Gene

No ASD Table

Relevant External Links for TSPAN18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN18 Gene

mRNA expression in normal human tissues for TSPAN18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN18 Gene

This gene is overexpressed in Heart - Atrial Appendage (5.7) and Heart - Left Ventricle (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TSPAN18 Gene

SOURCE GeneReport for Unigene cluster for TSPAN18 Gene Hs.385634

genes like me logo Genes that share expressions with TSPAN18: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN18 Gene

Orthologs for TSPAN18 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN18 35
  • 99.6 (n)
  • 100 (a)
TSPAN18 36
  • 100 (a)
(Bos Taurus)
Mammalia TSPAN18 35
  • 92.98 (n)
  • 96.76 (a)
TSPAN18 36
  • 95 (a)
(Canis familiaris)
Mammalia TSPAN18 35
  • 91.26 (n)
  • 95.56 (a)
TSPAN18 36
  • 96 (a)
(Mus musculus)
Mammalia Tspan18 35
  • 87.1 (n)
  • 90.73 (a)
Tspan18 16
Tspan18 36
  • 91 (a)
(Monodelphis domestica)
Mammalia TSPAN18 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN18 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Tspan18 35
  • 87.1 (n)
  • 90.32 (a)
(Gallus gallus)
Aves TSPAN18 35
  • 76.25 (n)
  • 81.38 (a)
TSPAN18 36
  • 81 (a)
(Anolis carolinensis)
Reptilia TSPAN18 36
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398586 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15520 35
tspan18 35
  • 71.52 (n)
  • 72.87 (a)
(Danio rerio)
Actinopterygii tspan18a 36
  • 67 (a)
tspan18b 35
  • 73.44 (n)
  • 72.76 (a)
tspan18b 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea tsp-11 36
  • 20 (a)
tsp-13 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
-- 36
  • 28 (a)
CSA.10478 36
  • 29 (a)
CSA.10827 36
  • 36 (a)
CSA.4407 36
  • 31 (a)
CSA.5127 36
  • 41 (a)
CSA.8143 36
  • 35 (a)
Species with no ortholog for TSPAN18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN18 Gene

Gene Tree for TSPAN18 (if available)
Gene Tree for TSPAN18 (if available)

Paralogs for TSPAN18 Gene

Paralogs for TSPAN18 Gene

genes like me logo Genes that share paralogs with TSPAN18: view

Variants for TSPAN18 Gene

Sequence variations from dbSNP and Humsavar for TSPAN18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs704662 -- 44,775,936(-) TTTCT(A/G)CTTAA intron-variant
rs704663 -- 44,755,012(+) GTGCT(A/G)TCTGC intron-variant
rs704664 -- 44,765,651(+) AGCAC(C/T)GAGTA intron-variant
rs704665 -- 44,796,570(-) CTGGG(C/T)GCTAT intron-variant
rs704666 -- 44,803,516(-) GCCTG(A/G)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN18 Gene

Variant ID Type Subtype PubMed ID
nsv832140 CNV Loss 17160897
esv28960 CNV Gain 19812545
nsv304 CNV Loss 18451855
nsv510252 CNV Loss 20534489
esv2744420 CNV Deletion 23290073

Relevant External Links for TSPAN18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN18 Gene

Disorders for TSPAN18 Gene

Relevant External Links for TSPAN18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TSPAN18: view

No data available for UniProtKB/Swiss-Prot for TSPAN18 Gene

Publications for TSPAN18 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue W.H. … Zhang D. (Nat. Genet. 2011) 3 48

Products for TSPAN18 Gene

Sources for TSPAN18 Gene

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