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Aliases for TSPAN18 Gene

Aliases for TSPAN18 Gene

  • Tetraspanin 18 2 3 5
  • Tspan-18 3 4
  • TSPAN 3

External Ids for TSPAN18 Gene

Previous GeneCards Identifiers for TSPAN18 Gene

  • GC11P044838
  • GC11P044496

Summaries for TSPAN18 Gene

GeneCards Summary for TSPAN18 Gene

TSPAN18 (Tetraspanin 18) is a Protein Coding gene. An important paralog of this gene is TSPAN9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN18 Gene

Genomics for TSPAN18 Gene

Regulatory Elements for TSPAN18 Gene

Enhancers for TSPAN18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN18 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN18 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN18 Gene

44,726,465 bp from pter
44,932,427 bp from pter
205,963 bases
Plus strand

Genomic View for TSPAN18 Gene

Genes around TSPAN18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN18 Gene

Proteins for TSPAN18 Gene

  • Protein details for TSPAN18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UY44
    • Q8NBI9

    Protein attributes for TSPAN18 Gene

    248 amino acids
    Molecular mass:
    27710 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11690.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPAN18 Gene

Proteomics data for TSPAN18 Gene at MOPED

Post-translational modifications for TSPAN18 Gene

  • Glycosylation at Asn 111 and Asn 129

No data available for DME Specific Peptides for TSPAN18 Gene

Domains & Families for TSPAN18 Gene

Gene Families for TSPAN18 Gene

Suggested Antigen Peptide Sequences for TSPAN18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN18: view

Function for TSPAN18 Gene

Phenotypes for TSPAN18 Gene

genes like me logo Genes that share phenotypes with TSPAN18: view

Animal Models for TSPAN18 Gene

MGI Knock Outs for TSPAN18:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN18

CRISPR Products

miRNA for TSPAN18 Gene

miRTarBase miRNAs that target TSPAN18

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN18 Gene

Localization for TSPAN18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN18 Gene COMPARTMENTS Subcellular localization image for TSPAN18 gene
Compartment Confidence
plasma membrane 5
nucleus 3

Gene Ontology (GO) - Cellular Components for TSPAN18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN18: view

Pathways & Interactions for TSPAN18 Gene

SuperPathways for TSPAN18 Gene

No Data Available

Interacting Proteins for TSPAN18 Gene

Gene Ontology (GO) - Biological Process for TSPAN18 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSPAN18 Gene

Drugs & Compounds for TSPAN18 Gene

No Compound Related Data Available

Transcripts for TSPAN18 Gene

Unigene Clusters for TSPAN18 Gene

Tetraspanin 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN18 Gene

No ASD Table

Relevant External Links for TSPAN18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN18 Gene

mRNA expression in normal human tissues for TSPAN18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN18 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.7) and Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for TSPAN18 Gene

This gene is overexpressed in Fetal Brain (20.0), Cerebral cortex (6.9), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN18 Gene

SOURCE GeneReport for Unigene cluster for TSPAN18 Gene Hs.385634

genes like me logo Genes that share expression patterns with TSPAN18: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPAN18 Gene

Orthologs for TSPAN18 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN18 35
  • 92.98 (n)
  • 96.76 (a)
TSPAN18 36
  • 95 (a)
(Canis familiaris)
Mammalia TSPAN18 35
  • 91.26 (n)
  • 95.56 (a)
TSPAN18 36
  • 96 (a)
(Mus musculus)
Mammalia Tspan18 35
  • 87.1 (n)
  • 90.73 (a)
Tspan18 16
Tspan18 36
  • 91 (a)
(Pan troglodytes)
Mammalia TSPAN18 35
  • 99.6 (n)
  • 100 (a)
TSPAN18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan18 35
  • 87.1 (n)
  • 90.32 (a)
(Monodelphis domestica)
Mammalia TSPAN18 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN18 36
  • 87 (a)
(Gallus gallus)
Aves TSPAN18 35
  • 76.25 (n)
  • 81.38 (a)
TSPAN18 36
  • 81 (a)
(Anolis carolinensis)
Reptilia TSPAN18 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15520 35
tspan18 35
  • 71.52 (n)
  • 72.87 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398586 35
(Danio rerio)
Actinopterygii tspan18b 35
  • 73.44 (n)
  • 72.76 (a)
tspan18a 36
  • 67 (a)
tspan18b 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea tsp-11 36
  • 20 (a)
tsp-13 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
-- 36
  • 28 (a)
CSA.10478 36
  • 29 (a)
CSA.10827 36
  • 36 (a)
CSA.4407 36
  • 31 (a)
CSA.5127 36
  • 41 (a)
CSA.8143 36
  • 35 (a)
Species with no ortholog for TSPAN18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN18 Gene

Gene Tree for TSPAN18 (if available)
Gene Tree for TSPAN18 (if available)

Paralogs for TSPAN18 Gene

Paralogs for TSPAN18 Gene

genes like me logo Genes that share paralogs with TSPAN18: view

Variants for TSPAN18 Gene

Sequence variations from dbSNP and Humsavar for TSPAN18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2291334 - 44,919,277(+) CAGAC(A/G)TCTTC reference, missense
rs704662 -- 44,775,936(-) TTTCT(A/G)CTTAA intron-variant
rs704663 -- 44,755,012(+) GTGCT(A/G)TCTGC intron-variant
rs704664 -- 44,765,651(+) AGCAC(C/T)GAGTA intron-variant
rs704665 -- 44,796,570(-) CTGGG(C/T)GCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN18 Gene

Variant ID Type Subtype PubMed ID
nsv832140 CNV Loss 17160897
esv28960 CNV Gain 19812545
nsv304 CNV Loss 18451855
nsv510252 CNV Loss 20534489
esv2744420 CNV Deletion 23290073

Variation tolerance for TSPAN18 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN18 Gene

Disorders for TSPAN18 Gene

Relevant External Links for TSPAN18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN18 Gene

Publications for TSPAN18 Gene

  1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue W.H. … Zhang D. (Nat. Genet. 2011) 3 48 67
  2. Specific tetraspanin functions. (PMID: 11756464) Hemler M.E. (J. Cell Biol. 2001) 2 3
  3. Lack of Association between the TSPAN18 Gene and Schizophrenia Based on New Data from Han Chinese and a Meta-Analysis. (PMID: 26016498) Zhang B. … Feng Z.F. (Int J Mol Sci 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Replication study confirms link between TSPAN18 mutation and schizophrenia in Han Chinese. (PMID: 23505562) Yuan J. … Shugart Y.Y. (PLoS ONE 2013) 3

Products for TSPAN18 Gene

Sources for TSPAN18 Gene