Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN17 Gene

Aliases for TSPAN17 Gene

  • Tetraspanin 17 2 3
  • F-Box Only Protein 23, Transmembrane 4 Superfamily Member 17 2 3
  • Tetraspan Protein SB134 3 4
  • TM4SF17 3 4
  • FBXO23 3 4
  • Transmembrane 4 Superfamily Member 17 4
  • F-Box Only Protein 23 4
  • Tetraspanin-17 3
  • Tspan-17 4
  • FBX23 3

External Ids for TSPAN17 Gene

Previous HGNC Symbols for TSPAN17 Gene

  • FBXO23
  • TM4SF17

Previous GeneCards Identifiers for TSPAN17 Gene

  • GC05P176008
  • GC05P176074
  • GC05P170998

Summaries for TSPAN17 Gene

Entrez Gene Summary for TSPAN17 Gene

  • This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for TSPAN17 Gene

TSPAN17 (Tetraspanin 17) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TSPAN7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN17 Gene

Genomics for TSPAN17 Gene

Regulatory Elements for TSPAN17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSPAN17 Gene

176,647,387 bp from pter
176,659,058 bp from pter
11,672 bases
Plus strand

Genomic View for TSPAN17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN17 Gene

Proteins for TSPAN17 Gene

  • Protein details for TSPAN17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6NXF7
    • Q96S98
    • Q9UKB9

    Protein attributes for TSPAN17 Gene

    270 amino acids
    Molecular mass:
    30264 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF04524.1; Type=Frameshift; Positions=66, 81, 83; Evidence={ECO:0000305};

    Alternative splice isoforms for TSPAN17 Gene


neXtProt entry for TSPAN17 Gene

Proteomics data for TSPAN17 Gene at MOPED

Post-translational modifications for TSPAN17 Gene

  • Glycosylation at Asn51 and Asn171

No data available for DME Specific Peptides for TSPAN17 Gene

Domains for TSPAN17 Gene

Gene Families for TSPAN17 Gene

Suggested Antigen Peptide Sequences for TSPAN17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN17: view

Function for TSPAN17 Gene

Gene Ontology (GO) - Molecular Function for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN17: view

Phenotypes for TSPAN17 Gene

GenomeRNAi human phenotypes for TSPAN17:
genes like me logo Genes that share phenotypes with TSPAN17: view

Animal Model Products

CRISPR Products

miRNA for TSPAN17 Gene

miRTarBase miRNAs that target TSPAN17

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN17

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN17 Gene

Localization for TSPAN17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN17 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN17 Gene COMPARTMENTS Subcellular localization image for TSPAN17 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN17: view

Pathways for TSPAN17 Gene

SuperPathways for TSPAN17 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TSPAN17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000309036 Q96FV3-TSN17_HUMAN for TSPAN17 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0072594 establishment of protein localization to organelle IDA 23091066
genes like me logo Genes that share ontologies with TSPAN17: view

No data available for Pathways by source for TSPAN17 Gene

Transcripts for TSPAN17 Gene

Unigene Clusters for TSPAN17 Gene

Tetraspanin 17:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: -
SP7: - - - - - - -

Relevant External Links for TSPAN17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN17 Gene

mRNA expression in normal human tissues for TSPAN17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TSPAN17 Gene Hs.532129

genes like me logo Genes that share expressions with TSPAN17: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TSPAN17 Gene

Orthologs for TSPAN17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN17 35
  • 95.56 (n)
  • 99.26 (a)
TSPAN17 36
  • 99 (a)
(Canis familiaris)
Mammalia TSPAN17 35
  • 90.83 (n)
  • 92.56 (a)
TSPAN17 36
  • 94 (a)
(Mus musculus)
Mammalia Tspan17 35
  • 91.36 (n)
  • 96.3 (a)
Tspan17 16
Tspan17 36
  • 96 (a)
(Pan troglodytes)
Mammalia TSPAN17 35
  • 99.29 (n)
  • 99.7 (a)
TSPAN17 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan17 35
  • 91.36 (n)
  • 94.81 (a)
(Monodelphis domestica)
Mammalia TSPAN17 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN17 36
  • 69 (a)
(Anolis carolinensis)
Reptilia TSPAN17 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan17 35
  • 78.27 (n)
  • 89.26 (a)
(Danio rerio)
Actinopterygii tspan17 35
  • 78.02 (n)
  • 87.04 (a)
TSPAN17 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 35
  • 57.16 (n)
  • 46.67 (a)
Tsp26A 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea tsp-12 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for TSPAN17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN17 Gene

Gene Tree for TSPAN17 (if available)
Gene Tree for TSPAN17 (if available)

Paralogs for TSPAN17 Gene Pseudogenes for TSPAN17 Gene

genes like me logo Genes that share paralogs with TSPAN17: view

Variants for TSPAN17 Gene

Sequence variations from dbSNP and Humsavar for TSPAN17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs748742 -- 176,657,893(+) TTATT(C/T)CCTGC utr-variant-3-prime
rs748743 -- 176,658,167(+) TCTTC(A/G)CCGTG utr-variant-3-prime
rs748744 -- 176,658,206(+) GGGCA(C/T)GCCAG utr-variant-3-prime
rs901744 -- 176,658,469(+) GTTGT(A/G)TAAAT utr-variant-3-prime
rs1061799 -- 176,655,624(+) CATTC(C/T)AGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN17 Gene

Variant ID Type Subtype PubMed ID
dgv6375n71 CNV Loss 21882294
nsv883144 CNV Loss 21882294
nsv883145 CNV Loss 21882294
nsv883146 CNV Loss 21882294
nsv462556 CNV Loss 19166990

Relevant External Links for TSPAN17 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN17 Gene

Disorders for TSPAN17 Gene

No disorders were found for TSPAN17 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TSPAN17 Gene

Publications for TSPAN17 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TSPAN17 Gene

Sources for TSPAN17 Gene

Back to Top