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Aliases for TSPAN17 Gene

Aliases for TSPAN17 Gene

  • Tetraspanin 17 2 3 5
  • F-Box Only Protein 23, Transmembrane 4 Superfamily Member 17 2 3
  • Tetraspan Protein SB134 3 4
  • TM4SF17 3 4
  • FBXO23 3 4
  • Transmembrane 4 Superfamily Member 17 4
  • F-Box Only Protein 23 4
  • Tetraspanin-17 3
  • Tspan-17 4
  • FBX23 3

External Ids for TSPAN17 Gene

Previous HGNC Symbols for TSPAN17 Gene

  • FBXO23
  • TM4SF17

Previous GeneCards Identifiers for TSPAN17 Gene

  • GC05P176008
  • GC05P176074
  • GC05P170998

Summaries for TSPAN17 Gene

Entrez Gene Summary for TSPAN17 Gene

  • This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for TSPAN17 Gene

TSPAN17 (Tetraspanin 17) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is TSPAN5.

UniProtKB/Swiss-Prot for TSPAN17 Gene

  • Regulates ADAM10 maturation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN17 Gene

Genomics for TSPAN17 Gene

Regulatory Elements for TSPAN17 Gene

Enhancers for TSPAN17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F176646 1 ENCODE 30.9 +0.5 541 3.0 HDGF ATF1 PKNOX1 SIN3A ZNF48 YY1 GLIS2 GATA2 ZNF143 KLF7 TSPAN17 GRK6 ENSG00000248996 GPRIN1 DOK3 HK3 ENSG00000248484
GH05F176653 1 Ensembl ENCODE 27.3 +6.0 6027 0.8 HDGF PKNOX1 MTA2 BHLHE40 TRIM22 BMI1 TBX21 ZFHX2 ZBTB48 EGR1 TSPAN17 ENSG00000248484
GH05F176657 1 Ensembl ENCODE 27.2 +11.4 11443 1.9 CTCF SAP130 ZNF2 RAD21 ZFHX2 EED ZNF143 SMC3 ZNF600 CREM TSPAN17 ENSG00000248484
GH05F176991 1.7 FANTOM5 Ensembl ENCODE 10.4 +348.0 348014 7.2 HDGF PKNOX1 ATF1 ARNT ZNF121 ZNF766 CBX5 GATA2 FOS NCOA1 ZNF346 GRK6 FAF2 ZNF346-IT1 ENSG00000247679 ENSG00000248996 DOK3 UIMC1 TSPAN17 LOC202181
GH05F176676 1.1 Ensembl ENCODE 14.3 +29.1 29114 1.0 CBX3 SMARCA5 ZEB2 ELF1 SMARCA4 GLIS1 IKZF1 MYNN HMBOX1 IRF1 TSPAN17 ENSG00000248484
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN17 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001297665 313 2201 HDGF PKNOX1 ATF1 SIN3A YY1 GLIS2 GATA2 ZNF143 KLF7 ZNF263

Genomic Location for TSPAN17 Gene

176,647,387 bp from pter
176,659,058 bp from pter
11,672 bases
Plus strand

Genomic View for TSPAN17 Gene

Genes around TSPAN17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN17 Gene

Proteins for TSPAN17 Gene

  • Protein details for TSPAN17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6NXF7
    • Q96S98
    • Q9UKB9

    Protein attributes for TSPAN17 Gene

    270 amino acids
    Molecular mass:
    30264 Da
    Quaternary structure:
    • Interacts with ADAM10.
    • Sequence=AAF04524.1; Type=Frameshift; Positions=66, 81, 83; Evidence={ECO:0000305};

    Alternative splice isoforms for TSPAN17 Gene


neXtProt entry for TSPAN17 Gene

Post-translational modifications for TSPAN17 Gene

  • Glycosylation at Asn 51 and Asn 171

No data available for DME Specific Peptides for TSPAN17 Gene

Domains & Families for TSPAN17 Gene

Gene Families for TSPAN17 Gene

Suggested Antigen Peptide Sequences for TSPAN17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN17: view

Function for TSPAN17 Gene

Molecular function for TSPAN17 Gene

UniProtKB/Swiss-Prot Function:
Regulates ADAM10 maturation.

Gene Ontology (GO) - Molecular Function for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN17: view
genes like me logo Genes that share phenotypes with TSPAN17: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN17

miRNA for TSPAN17 Gene

miRTarBase miRNAs that target TSPAN17

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN17 Gene

Localization for TSPAN17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN17 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN17 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN17: view

Pathways & Interactions for TSPAN17 Gene

SuperPathways for TSPAN17 Gene

No Data Available

Interacting Proteins for TSPAN17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000309036 Q96FV3-TSN17_HUMAN for TSPAN17 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0016567 protein ubiquitination NAS 10531035
GO:0045747 positive regulation of Notch signaling pathway IBA --
GO:0072594 establishment of protein localization to organelle IDA 23091066
GO:0090002 establishment of protein localization to plasma membrane IBA --
genes like me logo Genes that share ontologies with TSPAN17: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN17 Gene

Transcripts for TSPAN17 Gene

Unigene Clusters for TSPAN17 Gene

Tetraspanin 17:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: -
SP7: - - - - - - -

Relevant External Links for TSPAN17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TSPAN17 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN17 Gene:

genes like me logo Genes that share expression patterns with TSPAN17: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TSPAN17 Gene

Orthologs for TSPAN17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN17 34 35
  • 99.29 (n)
(Bos Taurus)
Mammalia TSPAN17 34 35
  • 95.56 (n)
(Monodelphis domestica)
Mammalia TSPAN17 35
  • 93 (a)
(Mus musculus)
Mammalia Tspan17 34 16 35
  • 91.36 (n)
(Rattus norvegicus)
Mammalia Tspan17 34
  • 91.36 (n)
(Canis familiaris)
Mammalia TSPAN17 34 35
  • 90.83 (n)
(Ornithorhynchus anatinus)
Mammalia TSPAN17 35
  • 69 (a)
(Anolis carolinensis)
Reptilia TSPAN17 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan17 34
  • 78.27 (n)
(Danio rerio)
Actinopterygii tspan17 34
  • 78.02 (n)
TSPAN17 35
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 34 35
  • 57.16 (n)
(Caenorhabditis elegans)
Secernentea tsp-12 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
Species where no ortholog for TSPAN17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN17 Gene

Gene Tree for TSPAN17 (if available)
Gene Tree for TSPAN17 (if available)

Paralogs for TSPAN17 Gene

Paralogs for TSPAN17 Gene Pseudogenes for TSPAN17 Gene

genes like me logo Genes that share paralogs with TSPAN17: view

Variants for TSPAN17 Gene

Sequence variations from dbSNP and Humsavar for TSPAN17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10213702 -- 176,651,546(+) GCTAC(C/G)GGGGA intron-variant
rs10214359 -- 176,649,825(+) CTAGA(C/T)GTGGT intron-variant
rs1061799 -- 176,655,624(+) CATTC(C/T)AGCGT intron-variant
rs1063266 -- 176,658,390(+) TGTGT(A/G)TGGAG utr-variant-3-prime
rs11134989 -- 176,648,648(+) GGCAG(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN17 Gene

Variant ID Type Subtype PubMed ID
nsv600347 CNV loss 21841781
nsv600346 CNV loss 21841781
nsv462556 CNV loss 19166990

Variation tolerance for TSPAN17 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN17 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN17 Gene

Disorders for TSPAN17 Gene

Relevant External Links for TSPAN17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN17 Gene

Publications for TSPAN17 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E. … Rubinstein E. (J. Cell Biol. 2012) 3 64

Products for TSPAN17 Gene

Sources for TSPAN17 Gene

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