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Aliases for TSPAN17 Gene

Aliases for TSPAN17 Gene

  • Tetraspanin 17 2 3
  • F-Box Only Protein 23, Transmembrane 4 Superfamily Member 17 2 3
  • Tetraspan Protein SB134 3 4
  • TM4SF17 3 4
  • FBXO23 3 4
  • Transmembrane 4 Superfamily Member 17 4
  • F-Box Only Protein 23 4
  • Tspan-17 4
  • FBX23 3

External Ids for TSPAN17 Gene

Previous HGNC Symbols for TSPAN17 Gene

  • FBXO23
  • TM4SF17

Previous GeneCards Identifiers for TSPAN17 Gene

  • GC05P176008
  • GC05P176074
  • GC05P170998

Summaries for TSPAN17 Gene

Entrez Gene Summary for TSPAN17 Gene

  • This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for TSPAN17 Gene

TSPAN17 (Tetraspanin 17) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is TSPAN7.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN17 Gene

Genomics for TSPAN17 Gene

Regulatory Elements for TSPAN17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSPAN17 Gene

Chromosome:
5
Start:
176,647,387 bp from pter
End:
176,659,058 bp from pter
Size:
11,672 bases
Orientation:
Plus strand

Genomic View for TSPAN17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN17 Gene

Proteins for TSPAN17 Gene

  • Protein details for TSPAN17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FV3-TSN17_HUMAN
    Recommended name:
    Tetraspanin-17
    Protein Accession:
    Q96FV3
    Secondary Accessions:
    • Q6NXF7
    • Q96S98
    • Q9UKB9

    Protein attributes for TSPAN17 Gene

    Size:
    270 amino acids
    Molecular mass:
    30264 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF04524.1; Type=Frameshift; Positions=66, 81, 83; Evidence={ECO:0000305};

    Alternative splice isoforms for TSPAN17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN17 Gene

Proteomics data for TSPAN17 Gene at MOPED

Post-translational modifications for TSPAN17 Gene

  • Glycosylation at Asn 51 and Asn 171

No data available for DME Specific Peptides for TSPAN17 Gene

Domains & Families for TSPAN17 Gene

Gene Families for TSPAN17 Gene

Suggested Antigen Peptide Sequences for TSPAN17 Gene

Graphical View of Domain Structure for InterPro Entry

Q96FV3

UniProtKB/Swiss-Prot:

TSN17_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN17: view

Function for TSPAN17 Gene

Gene Ontology (GO) - Molecular Function for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN17: view

Phenotypes for TSPAN17 Gene

genes like me logo Genes that share phenotypes with TSPAN17: view

Animal Model Products

CRISPR Products

miRNA for TSPAN17 Gene

miRTarBase miRNAs that target TSPAN17

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN17

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN17 Gene

Localization for TSPAN17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN17 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN17 Gene COMPARTMENTS Subcellular localization image for TSPAN17 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TSPAN17: view

Pathways & Interactions for TSPAN17 Gene

SuperPathways for TSPAN17 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TSPAN17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309036%0d%0a9606.ENSP00000261875%0d%0a
Selected Interacting proteins: Q96FV3-TSN17_HUMAN ENSP00000309036 for TSPAN17 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0045747 positive regulation of Notch signaling pathway IBA --
GO:0072594 establishment of protein localization to organelle IDA 23091066
GO:0090002 establishment of protein localization to plasma membrane IBA --
genes like me logo Genes that share ontologies with TSPAN17: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN17 Gene

Drugs & Compounds for TSPAN17 Gene

No Compound Related Data Available

Transcripts for TSPAN17 Gene

Unigene Clusters for TSPAN17 Gene

Tetraspanin 17:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: -
SP7: - - - - - - -
SP8:

Relevant External Links for TSPAN17 Gene

GeneLoc Exon Structure for
TSPAN17
ECgene alternative splicing isoforms for
TSPAN17

Expression for TSPAN17 Gene

mRNA expression in normal human tissues for TSPAN17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TSPAN17 Gene Hs.532129

genes like me logo Genes that share expression patterns with TSPAN17: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPAN17 Gene

Orthologs for TSPAN17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSPAN17 35
  • 95.56 (n)
  • 99.26 (a)
TSPAN17 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN17 35
  • 90.83 (n)
  • 92.56 (a)
TSPAN17 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan17 35
  • 91.36 (n)
  • 96.3 (a)
Tspan17 16
Tspan17 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSPAN17 35
  • 99.29 (n)
  • 99.7 (a)
TSPAN17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan17 35
  • 91.36 (n)
  • 94.81 (a)
oppossum
(Monodelphis domestica)
Mammalia TSPAN17 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN17 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN17 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan17 35
  • 78.27 (n)
  • 89.26 (a)
zebrafish
(Danio rerio)
Actinopterygii tspan17 35
  • 78.02 (n)
  • 87.04 (a)
TSPAN17 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 35
  • 57.16 (n)
  • 46.67 (a)
Tsp26A 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-12 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for TSPAN17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN17 Gene

ENSEMBL:
Gene Tree for TSPAN17 (if available)
TreeFam:
Gene Tree for TSPAN17 (if available)

Paralogs for TSPAN17 Gene

Pseudogenes.org Pseudogenes for TSPAN17 Gene

genes like me logo Genes that share paralogs with TSPAN17: view

Variants for TSPAN17 Gene

Sequence variations from dbSNP and Humsavar for TSPAN17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_057278 -

Structural Variations from Database of Genomic Variants (DGV) for TSPAN17 Gene

Variant ID Type Subtype PubMed ID
dgv6375n71 CNV Loss 21882294
nsv883144 CNV Loss 21882294
nsv883145 CNV Loss 21882294
nsv883146 CNV Loss 21882294
nsv462556 CNV Loss 19166990

Variation tolerance for TSPAN17 Gene

Residual Variation Intolerance Score: 34.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN17 Gene

HapMap Linkage Disequilibrium report
TSPAN17
Human Gene Mutation Database (HGMD)
TSPAN17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN17 Gene

Disorders for TSPAN17 Gene

Relevant External Links for TSPAN17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN17
genes like me logo Genes that share disorders with TSPAN17: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN17 Gene

Publications for TSPAN17 Gene

  1. Expression and function of transmembrane-4 superfamily (tetraspanin) proteins in osteoclasts: reciprocal roles of Tspan-5 and NET-6 during osteoclastogenesis. (PMID: 17965585) Iwai K. … Saeki Y. (Allergol Int 2007) 23 67
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 67
  3. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E. … Rubinstein E. (J. Cell Biol. 2012) 67

Products for TSPAN17 Gene

Sources for TSPAN17 Gene

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