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Aliases for TSPAN16 Gene

Aliases for TSPAN16 Gene

  • Tetraspanin 16 2 3 5
  • Transmembrane 4 Superfamily Member 16 2 3 4
  • Tetraspanin TM4-B 3 4
  • Tspan-16 3 4
  • TM4SF16 3 4
  • Tetraspanin-16 3
  • TM4-B 3
  • TM-8 3

External Ids for TSPAN16 Gene

Previous HGNC Symbols for TSPAN16 Gene

  • TM4SF16

Previous GeneCards Identifiers for TSPAN16 Gene

  • GC19P011406
  • GC19P010986

Summaries for TSPAN16 Gene

Entrez Gene Summary for TSPAN16 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for TSPAN16 Gene

TSPAN16 (Tetraspanin 16) is a Protein Coding gene.

Additional gene information for TSPAN16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN16 Gene

Genomics for TSPAN16 Gene

Regulatory Elements for TSPAN16 Gene

Enhancers for TSPAN16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H011317 1.3 Ensembl ENCODE 24.6 +25.7 25744 8.6 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B NFYC JUNB REST SMARCB1 ENSG00000267174 TSPAN16 ILF3 TIMM29 ZNF844 ZNF433 ZNF627 KRI1 SWSAP1 ZNF136
GH19H011452 1.1 Ensembl dbSUPER 12.1 +157.6 157602 2.5 TBL1XR1 ARID4B RARA TCF12 ZNF366 THAP11 ZNF362 CEBPB SMARCA4 CEBPA ELAVL3 TSPAN16 EPOR SWSAP1 GC19M011460 CCDC151
GH19H011360 1 Ensembl ENCODE 11.8 +65.6 65584 2.2 KLF1 MAX ZIC2 HIC1 GLIS2 MTA3 POLR2A SCRT2 ZSCAN29 L3MBTL2 RGL3 PLPPR2 EPOR TSPAN16 SWSAP1
GH19H011443 0.9 dbSUPER 12 +150.4 150432 5.7 HDGF ARID4B KLF17 ZNF2 RAD21 GLIS2 ZNF366 ZNF143 ZNF391 EGR2 ELAVL3 EPOR TSPAN16 KANK2 PRKCSH ENSG00000267174 CCDC159 CCDC151 GC19M011460
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TSPAN16 Gene

Genomic Locations for TSPAN16 Gene
30,858 bases
Plus strand

Genomic View for TSPAN16 Gene

Genes around TSPAN16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN16 Gene

Proteins for TSPAN16 Gene

  • Protein details for TSPAN16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • K7EN22
    • K7EPD8
    • Q8N6J7

    Protein attributes for TSPAN16 Gene

    245 amino acids
    Molecular mass:
    26266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN16 Gene


neXtProt entry for TSPAN16 Gene

Post-translational modifications for TSPAN16 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TSPAN16 Gene

Domains & Families for TSPAN16 Gene

Gene Families for TSPAN16 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN16 Gene

Suggested Antigen Peptide Sequences for TSPAN16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN16: view

Function for TSPAN16 Gene

Phenotypes From GWAS Catalog for TSPAN16 Gene

Phenotypes for TSPAN16 Gene

GenomeRNAi human phenotypes for TSPAN16:
genes like me logo Genes that share phenotypes with TSPAN16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN16 Gene

Localization for TSPAN16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN16 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 10500248
genes like me logo Genes that share ontologies with TSPAN16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPAN16 Gene

Pathways & Interactions for TSPAN16 Gene

SuperPathways for TSPAN16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN16: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN16 Gene

Drugs & Compounds for TSPAN16 Gene

No Compound Related Data Available

Transcripts for TSPAN16 Gene

Unigene Clusters for TSPAN16 Gene

Tetraspanin 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN16 Gene

No ASD Table

Relevant External Links for TSPAN16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN16 Gene

mRNA differential expression in normal tissues according to GTEx for TSPAN16 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for TSPAN16 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN16 Gene

Protein tissue co-expression partners for TSPAN16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSPAN16 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN16 Gene:


mRNA Expression by UniProt/SwissProt for TSPAN16 Gene:

Tissue specificity: Broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues.

Evidence on tissue expression from TISSUES for TSPAN16 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TSPAN16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN16 Gene

Orthologs for TSPAN16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSPAN16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN16 33 34
  • 98.77 (n)
(Canis familiaris)
Mammalia TSPAN16 33
  • 81.15 (n)
(Bos Taurus)
Mammalia TSPAN16 34
  • 70 (a)
Species where no ortholog for TSPAN16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSPAN16 Gene

Gene Tree for TSPAN16 (if available)
Gene Tree for TSPAN16 (if available)

Paralogs for TSPAN16 Gene

(4) SIMAP similar genes for TSPAN16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSPAN16: view

No data available for Paralogs for TSPAN16 Gene

Variants for TSPAN16 Gene

Sequence variations from dbSNP and Humsavar for TSPAN16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000046177 -- 11,299,151(+) TAGCA(A/C/G/T)GCACT intron-variant
rs1000077410 -- 11,299,338(+) CCATG(A/T)TCGAT intron-variant
rs1000192517 -- 11,324,606(+) TTGGG(C/T)GAATC intron-variant, utr-variant-3-prime
rs1000239102 -- 11,320,008(+) GAGAC(-/G)GGGGT intron-variant
rs1000323193 -- 11,305,705(+) TACAA(C/T)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN16 Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV loss 17160897
nsv578615 CNV loss 21841781
nsv519802 CNV loss 19592680
nsv1116300 CNV deletion 24896259
esv3643670 CNV loss 21293372
esv3643669 CNV loss 21293372
esv3643668 CNV loss 21293372
esv2659694 CNV deletion 23128226

Variation tolerance for TSPAN16 Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN16 Gene

Disorders for TSPAN16 Gene

Relevant External Links for TSPAN16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN16 Gene

Publications for TSPAN16 Gene

  1. The molecular characterisation of a novel tetraspanin protein, TM4-B(1). (PMID: 10500248) Puls KL … Wright MD (Biochimica et biophysica acta 1999) 2 3 4 60
  2. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D … Pajukanta P (Journal of medical genetics 2013) 3 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for TSPAN16 Gene

Sources for TSPAN16 Gene

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