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Aliases for TSPAN16 Gene

Aliases for TSPAN16 Gene

  • Tetraspanin 16 2 3
  • Transmembrane 4 Superfamily Member 16 2 3 4
  • Tetraspanin TM4-B 3 4
  • Tspan-16 3 4
  • TM4SF16 3 4
  • Tetraspanin-16 3
  • TM4-B 3
  • TM-8 3

External Ids for TSPAN16 Gene

Previous HGNC Symbols for TSPAN16 Gene

  • TM4SF16

Previous GeneCards Identifiers for TSPAN16 Gene

  • GC19P011406
  • GC19P010986

Summaries for TSPAN16 Gene

Entrez Gene Summary for TSPAN16 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for TSPAN16 Gene

TSPAN16 (Tetraspanin 16) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN16 Gene

Genomics for TSPAN16 Gene

Regulatory Elements for TSPAN16 Gene

Genomic Location for TSPAN16 Gene

11,296,139 bp from pter
11,326,996 bp from pter
30,858 bases
Plus strand

Genomic View for TSPAN16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN16 Gene

Proteins for TSPAN16 Gene

  • Protein details for TSPAN16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • K7EN22
    • K7EPD8
    • Q8N6J7

    Protein attributes for TSPAN16 Gene

    245 amino acids
    Molecular mass:
    26266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN16 Gene


neXtProt entry for TSPAN16 Gene

Proteomics data for TSPAN16 Gene at MOPED

Post-translational modifications for TSPAN16 Gene

No Post-translational modifications

Other Protein References for TSPAN16 Gene

No data available for DME Specific Peptides for TSPAN16 Gene

Domains for TSPAN16 Gene

Gene Families for TSPAN16 Gene

Protein Domains for TSPAN16 Gene

Suggested Antigen Peptide Sequences for TSPAN16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN16: view

Function for TSPAN16 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN16

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPAN16 Gene

Localization for TSPAN16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN16 Gene COMPARTMENTS Subcellular localization image for TSPAN16 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPAN16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN16: view

Pathways for TSPAN16 Gene

SuperPathways for TSPAN16 Gene

No Data Available

Interacting Proteins for TSPAN16 Gene

Gene Ontology (GO) - Biological Process for TSPAN16 Gene


No data available for Pathways by source for TSPAN16 Gene

Transcripts for TSPAN16 Gene

mRNA/cDNA for TSPAN16 Gene

Unigene Clusters for TSPAN16 Gene

Tetraspanin 16:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN16 Gene

No ASD Table

Relevant External Links for TSPAN16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN16 Gene

mRNA expression in normal human tissues for TSPAN16 Gene

mRNA differential expression in normal tissues according to GTEx for TSPAN16 Gene

This gene is overexpressed in Testis (49.3).

Protein differential expression in normal tissues for TSPAN16 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TSPAN16 Gene

SOURCE GeneReport for Unigene cluster for TSPAN16 Gene Hs.579784

mRNA Expression by UniProt/SwissProt for TSPAN16 Gene

Tissue specificity: Broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues
genes like me logo Genes that share expressions with TSPAN16: view

Expression partners for TSPAN16 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TSPAN16 Gene

Orthologs for TSPAN16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSPAN16 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TSPAN16 35
  • 81.15 (n)
  • 76.19 (a)
(Pan troglodytes)
Mammalia TSPAN16 35
  • 98.77 (n)
  • 97.54 (a)
TSPAN16 36
  • 98 (a)
(Bos Taurus)
Mammalia TSPAN16 36
  • 70 (a)
Species with no ortholog for TSPAN16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSPAN16 Gene

Gene Tree for TSPAN16 (if available)
Gene Tree for TSPAN16 (if available)

Paralogs for TSPAN16 Gene

(4) SIMAP similar genes for TSPAN16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSPAN16: view

No data available for Paralogs for TSPAN16 Gene

Variants for TSPAN16 Gene

Sequence variations from dbSNP and Humsavar for TSPAN16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs94513 -- 11,297,079(-) GACAA(C/T)TACTT intron-variant
rs94514 -- 11,297,065(-) tttat(G/T)ttttt intron-variant
rs94515 -- 11,297,028(-) agtct(C/T)gctat intron-variant
rs94517 -- 11,296,639(+) GTAGC(C/T)GACCA intron-variant
rs184377 -- 11,297,719(-) aggag(A/T)tcgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN16 Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV Loss 17160897
nsv519802 CNV Loss 19592680
esv2659694 CNV Deletion 23128226

Relevant External Links for TSPAN16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN16 Gene

Disorders for TSPAN16 Gene

No disorders were found for TSPAN16 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TSPAN16 Gene

Publications for TSPAN16 Gene

  1. The molecular characterisation of a novel tetraspanin protein, TM4- B. (PMID: 10500248) Puls K.L. … Wright M.D. (Biochim. Biophys. Acta 1999) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TSPAN16 Gene

Sources for TSPAN16 Gene

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