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Aliases for TSPAN15 Gene

Aliases for TSPAN15 Gene

  • Tetraspanin 15 2 3 5
  • Transmembrane 4 Superfamily Member 15 2 3 4
  • Tetraspan NET-7 3 4
  • Tspan-15 3 4
  • TM4SF15 3 4
  • NET7 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-7 3
  • 2700063A19Rik 3
  • NET-7 3

External Ids for TSPAN15 Gene

Previous HGNC Symbols for TSPAN15 Gene

  • TM4SF15

Previous GeneCards Identifiers for TSPAN15 Gene

  • GC10P070882
  • GC10P071211
  • GC10P065211

Summaries for TSPAN15 Gene

Entrez Gene Summary for TSPAN15 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN15 Gene

TSPAN15 (Tetraspanin 15) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is ENSG00000250349.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN15 Gene

Genomics for TSPAN15 Gene

Regulatory Elements for TSPAN15 Gene

Enhancers for TSPAN15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN15 Gene

69,425,218 bp from pter
69,507,669 bp from pter
82,452 bases
Plus strand

Genomic View for TSPAN15 Gene

Genes around TSPAN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN15 Gene

Proteins for TSPAN15 Gene

  • Protein details for TSPAN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UW79

    Protein attributes for TSPAN15 Gene

    294 amino acids
    Molecular mass:
    33165 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN15 Gene

Proteomics data for TSPAN15 Gene at MOPED

Post-translational modifications for TSPAN15 Gene

  • Glycosylation at Asn 118, Asn 189, and Asn 230
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPAN15 Gene

Domains & Families for TSPAN15 Gene

Gene Families for TSPAN15 Gene

Protein Domains for TSPAN15 Gene

Suggested Antigen Peptide Sequences for TSPAN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN15: view

Function for TSPAN15 Gene

genes like me logo Genes that share phenotypes with TSPAN15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN15

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN15 Gene

Localization for TSPAN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN15 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN15 Gene COMPARTMENTS Subcellular localization image for TSPAN15 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
GO:0070062 extracellular exosome IDA 23376485
GO:0097197 tetraspanin-enriched microdomain IEA --
genes like me logo Genes that share ontologies with TSPAN15: view

Pathways & Interactions for TSPAN15 Gene

SuperPathways for TSPAN15 Gene

No Data Available

Interacting Proteins for TSPAN15 Gene

Gene Ontology (GO) - Biological Process for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN15: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN15 Gene

Drugs & Compounds for TSPAN15 Gene

No Compound Related Data Available

Transcripts for TSPAN15 Gene

Unigene Clusters for TSPAN15 Gene

Tetraspanin 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: -

Relevant External Links for TSPAN15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN15 Gene

mRNA expression in normal human tissues for TSPAN15 Gene

Protein differential expression in normal tissues from HIPED for TSPAN15 Gene

This gene is overexpressed in Frontal cortex (12.6), Pancreas (8.2), and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN15 Gene

SOURCE GeneReport for Unigene cluster for TSPAN15 Gene Hs.499941

genes like me logo Genes that share expression patterns with TSPAN15: view

Protein tissue co-expression partners for TSPAN15 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSPAN15 Gene

Orthologs for TSPAN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN15 35
  • 91.24 (n)
  • 92.83 (a)
TSPAN15 36
  • 93 (a)
(Canis familiaris)
Mammalia TSPAN15 35
  • 91.38 (n)
  • 93.54 (a)
TSPAN15 36
  • 94 (a)
(Mus musculus)
Mammalia Tspan15 35
  • 88.1 (n)
  • 91.84 (a)
Tspan15 16
Tspan15 36
  • 92 (a)
(Pan troglodytes)
Mammalia TSPAN15 35
  • 99.66 (n)
  • 100 (a)
TSPAN15 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan15 35
  • 86.28 (n)
  • 90.82 (a)
(Monodelphis domestica)
Mammalia TSPAN15 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN15 36
  • 72 (a)
(Gallus gallus)
Aves TSPAN15 35
  • 75.77 (n)
  • 79.18 (a)
TSPAN15 36
  • 79 (a)
(Anolis carolinensis)
Reptilia TSPAN15 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1562 35
tspan15 35
  • 68.05 (n)
  • 71.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6438 35
(Danio rerio)
Actinopterygii tspan15 35
  • 66.55 (n)
  • 66.78 (a)
tspan15 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp3A 36
  • 30 (a)
Tsp86D 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for TSPAN15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN15 Gene

Gene Tree for TSPAN15 (if available)
Gene Tree for TSPAN15 (if available)

Paralogs for TSPAN15 Gene

(6) SIMAP similar genes for TSPAN15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSPAN15: view

Variants for TSPAN15 Gene

Sequence variations from dbSNP and Humsavar for TSPAN15 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1430882 -- 69,492,450(+) GCACA(A/C)TTGCA intron-variant, upstream-variant-2KB
rs11068 -- 69,507,167(+) TCCCC(A/G/T)AAGAG nc-transcript-variant, utr-variant-3-prime
rs1624453 -- 69,469,973(+) ATGGT(A/G)TTGGA intron-variant
rs1652802 -- 69,507,944(-) AACTC(C/T)GCTTC downstream-variant-500B
rs1652803 -- 69,507,663(-) AAAAA(A/C)AAAAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TSPAN15 Gene

Variant ID Type Subtype PubMed ID
nsv895696 CNV Gain 21882294
nsv523004 CNV Loss 19592680
esv2678828 CNV Deletion 23128226
nsv524063 CNV Loss 19592680
nsv7021 CNV Loss 18451855
nsv524514 CNV Loss 19592680
nsv508590 CNV Loss 20534489
nsv467356 CNV Loss 19166990
esv32737 CNV Gain+Loss 17666407

Variation tolerance for TSPAN15 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN15 Gene

Disorders for TSPAN15 Gene

Relevant External Links for TSPAN15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN15 Gene

Publications for TSPAN15 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48 67
  2. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F. (J. Cell. Sci. 2001) 2 3
  3. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V. … Rubinstein E. (Biochim. Biophys. Acta 2000) 2 3
  4. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. (PMID: 25772935) Germain M. … Morange P.E. (Am. J. Hum. Genet. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TSPAN15 Gene

Sources for TSPAN15 Gene