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Aliases for TSPAN15 Gene

Aliases for TSPAN15 Gene

  • Tetraspanin 15 2 3 5
  • Transmembrane 4 Superfamily Member 15 2 3 4
  • Tetraspan NET-7 3 4
  • Tspan-15 3 4
  • TM4SF15 3 4
  • NET7 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-7 3
  • Tetraspanin-15 3
  • 2700063A19Rik 3
  • NET-7 3

External Ids for TSPAN15 Gene

Previous HGNC Symbols for TSPAN15 Gene

  • TM4SF15

Previous GeneCards Identifiers for TSPAN15 Gene

  • GC10P070882
  • GC10P071211
  • GC10P065211

Summaries for TSPAN15 Gene

Entrez Gene Summary for TSPAN15 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN15 Gene

TSPAN15 (Tetraspanin 15) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN33.

UniProtKB/Swiss-Prot for TSPAN15 Gene

  • Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN15 Gene

Genomics for TSPAN15 Gene

Regulatory Elements for TSPAN15 Gene

Enhancers for TSPAN15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G069445 1.6 Ensembl ENCODE dbSUPER 43.7 +24.4 24375 9.0 FOXA2 PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 CBX5 ZNF143 TSPAN15 CCAR1 DDX50 DDX21 C10orf35 TYSND1 TACR2 AIFM2 ATP5G1P7 GC10M069447
GH10G069456 1.5 Ensembl ENCODE dbSUPER 35.8 +34.1 34135 5.6 PKNOX1 FEZF1 ZNF2 FOS ZNF263 SP3 REST SMARCA4 GLIS1 NR2C1 TSPAN15 CCAR1 DDX50 GC10M069447 ATP5G1P7
GH10G069436 1.3 Ensembl ENCODE dbSUPER 38.9 +13.6 13628 4.4 ELF3 PKNOX1 ZNF350 RCOR1 FOS DEK ZHX1 SMARCC1 CEBPB ELF1 TSPAN15 C10orf35 HK1 ENSG00000231748 DDX50 ATP5G1P7 GC10M069447
GH10G069477 1.4 Ensembl ENCODE dbSUPER 33.4 +54.9 54910 5.1 HDAC1 PKNOX1 FEZF1 RAD21 ZNF766 GATA2 SCRT2 EGR2 SMAD5 CEBPB TSPAN15 C10orf35 ENSG00000231748 HK1 GC10M069447 TMEM256P1
GH10G069490 1.1 ENCODE dbSUPER 40.2 +70.3 70280 9.1 PKNOX1 RAD21 ZNF23 GATA2 SCRT2 ZSCAN5C ZMIZ1 FOS EGR2 SMARCA5 TSPAN15 NEUROG3 LOC101929021 C10orf35 TMEM256P1 GC10M069447
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN15 Gene

69,425,218 bp from pter
69,507,669 bp from pter
82,452 bases
Plus strand

Genomic View for TSPAN15 Gene

Genes around TSPAN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN15 Gene

Proteins for TSPAN15 Gene

  • Protein details for TSPAN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6UW79

    Protein attributes for TSPAN15 Gene

    294 amino acids
    Molecular mass:
    33165 Da
    Quaternary structure:
    • Interacts with ADAM10; the interacation influences ADAM10 substrate specificity.

neXtProt entry for TSPAN15 Gene

Post-translational modifications for TSPAN15 Gene

  • Glycosylation at posLast=118118, Asn189, and Asn230
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN15 Gene

No data available for DME Specific Peptides for TSPAN15 Gene

Domains & Families for TSPAN15 Gene

Gene Families for TSPAN15 Gene

Protein Domains for TSPAN15 Gene

Suggested Antigen Peptide Sequences for TSPAN15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN15: view

Function for TSPAN15 Gene

Molecular function for TSPAN15 Gene

UniProtKB/Swiss-Prot Function:
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.

Gene Ontology (GO) - Molecular Function for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN15: view
genes like me logo Genes that share phenotypes with TSPAN15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN15

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN15 Gene

Localization for TSPAN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN15 Gene

Cell membrane; Multi-pass membrane protein. Late endosome membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN15 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 3
nucleus 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA,IDA 23091066
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TSPAN15: view

Pathways & Interactions for TSPAN15 Gene

SuperPathways for TSPAN15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008593 NOT regulation of Notch signaling pathway IMP 23091066
GO:0051604 protein maturation IMP 23091066
GO:0090002 establishment of protein localization to plasma membrane IMP 23091066
genes like me logo Genes that share ontologies with TSPAN15: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN15 Gene

Drugs & Compounds for TSPAN15 Gene

No Compound Related Data Available

Transcripts for TSPAN15 Gene

Unigene Clusters for TSPAN15 Gene

Tetraspanin 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: -

Relevant External Links for TSPAN15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN15 Gene

Protein differential expression in normal tissues from HIPED for TSPAN15 Gene

This gene is overexpressed in Frontal cortex (12.6), Pancreas (8.2), and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPAN15 Gene

Protein tissue co-expression partners for TSPAN15 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN15 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN15 Gene:


Evidence on tissue expression from TISSUES for TSPAN15 Gene

  • Kidney(4.3)
genes like me logo Genes that share expression patterns with TSPAN15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN15 Gene

Orthologs for TSPAN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN15 34 35
  • 99.66 (n)
(Canis familiaris)
Mammalia TSPAN15 34 35
  • 91.38 (n)
(Bos Taurus)
Mammalia TSPAN15 34 35
  • 91.24 (n)
(Mus musculus)
Mammalia Tspan15 34 16 35
  • 88.1 (n)
(Rattus norvegicus)
Mammalia Tspan15 34
  • 86.28 (n)
(Monodelphis domestica)
Mammalia TSPAN15 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN15 35
  • 72 (a)
(Gallus gallus)
Aves TSPAN15 34 35
  • 75.77 (n)
(Anolis carolinensis)
Reptilia TSPAN15 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan15 34
  • 68.05 (n)
Str.1562 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6438 34
(Danio rerio)
Actinopterygii tspan15 34 35
  • 66.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp3A 35
  • 30 (a)
Tsp86D 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for TSPAN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN15 Gene

Gene Tree for TSPAN15 (if available)
Gene Tree for TSPAN15 (if available)

Paralogs for TSPAN15 Gene

(6) SIMAP similar genes for TSPAN15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSPAN15: view

Variants for TSPAN15 Gene

Sequence variations from dbSNP and Humsavar for TSPAN15 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000039404 -- 69,536,795(+) GCCTG(A/G)CCAAC intron-variant
rs1000043368 -- 69,493,103(+) CCCCA(A/G)CCACA intron-variant, upstream-variant-2KB
rs1000052664 -- 69,548,368(+) TCCTG(A/G)TGTTT nc-transcript-variant, utr-variant-3-prime
rs1000108204 -- 69,542,406(+) GTTCC(A/G)AAGTT intron-variant
rs1000111684 -- 69,453,780(+) CCACC(C/T)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN15 Gene

Variant ID Type Subtype PubMed ID
esv2678828 CNV deletion 23128226
esv32737 CNV gain+loss 17666407
esv3623745 CNV gain 21293372
esv3623746 CNV loss 21293372
nsv467356 CNV loss 19166990
nsv508590 CNV deletion 20534489
nsv523004 CNV loss 19592680
nsv524063 CNV loss 19592680
nsv524514 CNV loss 19592680
nsv551454 CNV loss 21841781
nsv7021 CNV deletion 18451855

Variation tolerance for TSPAN15 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN15 Gene

Disorders for TSPAN15 Gene

Relevant External Links for TSPAN15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN15 Gene

Publications for TSPAN15 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F. (J. Cell. Sci. 2001) 2 3 64
  5. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V. … Rubinstein E. (Biochim. Biophys. Acta 2000) 2 3 64

Products for TSPAN15 Gene

Sources for TSPAN15 Gene

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