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Aliases for TSPAN14 Gene

Aliases for TSPAN14 Gene

  • Tetraspanin 14 2 3 5
  • Transmembrane 4 Superfamily Member 14 2 3 4
  • Tspan-14 3 4
  • DC-TM4F2 3 4
  • TM4SF14 3 4
  • Tetraspanin Similar To TM4SF9 3
  • Tetraspanin-14 3

External Ids for TSPAN14 Gene

Previous HGNC Symbols for TSPAN14 Gene

  • TM4SF14

Previous GeneCards Identifiers for TSPAN14 Gene

  • GC10P082205
  • GC10P076057
  • GC10P080487
  • GC10P080502

Summaries for TSPAN14 Gene

GeneCards Summary for TSPAN14 Gene

TSPAN14 (Tetraspanin 14) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN5.

UniProtKB/Swiss-Prot for TSPAN14 Gene

  • Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).

Additional gene information for TSPAN14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN14 Gene

Genomics for TSPAN14 Gene

Regulatory Elements for TSPAN14 Gene

Enhancers for TSPAN14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H080492 2 FANTOM5 Ensembl ENCODE dbSUPER 23 +46.2 46156 15 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 TSPAN14 FAM213A DYDC1 DYDC2 LOC101929574 ANXA11 PIR41876
GH10H080483 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22 +33.7 33696 9.5 MLX ARID4B YY1 TCF12 GTF3C2 FOS RUNX3 SP5 PPARG ZNF623 TSPAN14 ENSG00000272489 FAM213A DYDC1 DYDC2 LOC101929574 ANXA11 PIR41876
GH10H080453 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 +10.2 10202 22.7 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF766 ZNF143 ZNF207 FOS SP5 FAM213A TSPAN14 LOC101929574 DYDC1 DYDC2 ANXA11 PLAC9 MBL1P SH2D4B PIR41876
GH10H080508 0.9 ENCODE dbSUPER 21.6 +56.1 56131 3.8 HDGF CTCF JUN MAX NR3C1 ZIC2 NR2F2 JUND FOXP2 FOS TSPAN14 FAM213A DYDC1 DYDC2 PIR41876 PIR63069
GH10H080428 1 ENCODE dbSUPER 18.2 -24.3 -24326 2 KLF1 MXI1 JUN MAX KLF17 BRCA1 RFX5 CTBP1 POLR2A FOSL2 TSPAN14 FAM213A DYDC1 DYDC2 ENSG00000235858 ANXA11 LOC101929574 PIR57963
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN14 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000030774 534 2201 HDGF SIN3A DMAP1 GLIS2 ATF7 ZNF592 MEF2D ZNF610 SMARCA4 GLIS1

Genomic Locations for TSPAN14 Gene

Genomic Locations for TSPAN14 Gene
chr10:80,454,166-80,533,123
(GRCh38/hg38)
Size:
78,958 bases
Orientation:
Plus strand
chr10:82,213,922-82,292,879
(GRCh37/hg19)

Genomic View for TSPAN14 Gene

Genes around TSPAN14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN14 Gene

Proteins for TSPAN14 Gene

  • Protein details for TSPAN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG11-TSN14_HUMAN
    Recommended name:
    Tetraspanin-14
    Protein Accession:
    Q8NG11
    Secondary Accessions:
    • A6NHE1
    • B4DHY6
    • D3DWD7
    • D3DWD8
    • Q567U7
    • Q9BU34
    • Q9H0U1

    Protein attributes for TSPAN14 Gene

    Size:
    270 amino acids
    Molecular mass:
    30691 Da
    Quaternary structure:
    • Interacts with ADAM10; the interaction promotes ADAM10 maturation and cell surface expression.

    Alternative splice isoforms for TSPAN14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN14 Gene

Post-translational modifications for TSPAN14 Gene

  • Ubiquitination at posLast=265265
  • Glycosylation at posLast=169169
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSPAN14 Gene

Domains & Families for TSPAN14 Gene

Gene Families for TSPAN14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q8NG11

UniProtKB/Swiss-Prot:

TSN14_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN14: view

Function for TSPAN14 Gene

Molecular function for TSPAN14 Gene

UniProtKB/Swiss-Prot Function:
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).

Phenotypes From GWAS Catalog for TSPAN14 Gene

Gene Ontology (GO) - Molecular Function for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN14: view
genes like me logo Genes that share phenotypes with TSPAN14: view

Animal Model Products

CRISPR Products

miRNA for TSPAN14 Gene

miRTarBase miRNAs that target TSPAN14

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN14 Gene

Localization for TSPAN14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN14 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with TSPAN14: view

Pathways & Interactions for TSPAN14 Gene

genes like me logo Genes that share pathways with TSPAN14: view

Pathways by source for TSPAN14 Gene

3 Reactome pathways for TSPAN14 Gene

Gene Ontology (GO) - Biological Process for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
GO:0045747 positive regulation of Notch signaling pathway IMP 23091066
GO:0051604 protein maturation IMP 23091066
GO:0072659 protein localization to plasma membrane IMP 23035126
GO:0090002 establishment of protein localization to plasma membrane IMP --
genes like me logo Genes that share ontologies with TSPAN14: view

No data available for SIGNOR curated interactions for TSPAN14 Gene

Drugs & Compounds for TSPAN14 Gene

No Compound Related Data Available

Transcripts for TSPAN14 Gene

Unigene Clusters for TSPAN14 Gene

Tetraspanin 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5:
SP6: -
SP7: - - - -
SP8:

Relevant External Links for TSPAN14 Gene

GeneLoc Exon Structure for
TSPAN14
ECgene alternative splicing isoforms for
TSPAN14

Expression for TSPAN14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN14 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for TSPAN14 Gene

This gene is overexpressed in Cerebrospinal fluid (35.7) and Esophagus (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPAN14 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSPAN14 Gene:

TSPAN14

SOURCE GeneReport for Unigene cluster for TSPAN14 Gene:

Hs.718943

Evidence on tissue expression from TISSUES for TSPAN14 Gene

  • Skin(4.7)
  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with TSPAN14: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN14 Gene

Orthologs for TSPAN14 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN14 33 34
  • 99.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN14 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN14 33 34
  • 91.6 (n)
dog
(Canis familiaris)
Mammalia TSPAN14 33 34
  • 91.6 (n)
mouse
(Mus musculus)
Mammalia Tspan14 33 16 34
  • 90.62 (n)
rat
(Rattus norvegicus)
Mammalia Tspan14 33
  • 89.88 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPAN14 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN14 33 34
  • 75.68 (n)
lizard
(Anolis carolinensis)
Reptilia TSPAN14 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan14 33
  • 71.23 (n)
zebrafish
(Danio rerio)
Actinopterygii tspan14 33 34
  • 68.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-12 34
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for TSPAN14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN14 Gene

ENSEMBL:
Gene Tree for TSPAN14 (if available)
TreeFam:
Gene Tree for TSPAN14 (if available)

Paralogs for TSPAN14 Gene

(10) SIMAP similar genes for TSPAN14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN14: view

Variants for TSPAN14 Gene

Sequence variations from dbSNP and Humsavar for TSPAN14 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000022393 -- 80,470,866(+) CACTG(A/C)AGGCT intron-variant
rs1000055194 -- 80,492,040(+) GCTCT(G/T)GGCAC intron-variant
rs1000098560 -- 80,508,899(+) GACAC(C/T)CCAGG intron-variant
rs1000109061 -- 80,469,498(+) AGCTT(A/G)CTTCC intron-variant
rs1000123744 -- 80,511,339(+) GCTGT(A/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN14 Gene

Variant ID Type Subtype PubMed ID
nsv831924 CNV loss 17160897
nsv831923 CNV loss 17160897
nsv7354 CNV deletion 18451855
nsv551642 CNV loss 21841781
nsv524518 CNV loss 19592680
nsv469837 CNV loss 16826518
nsv1141879 OTHER inversion 24896259
nsv1118181 CNV deletion 24896259
esv6437 CNV gain 19470904
esv28286 CNV loss 19812545
esv2664515 CNV deletion 23128226
esv2460472 CNV deletion 19546169
dgv1292n54 CNV gain 21841781
dgv1291n54 CNV gain+loss 21841781

Variation tolerance for TSPAN14 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN14 Gene

Disorders for TSPAN14 Gene

Relevant External Links for TSPAN14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN14

No disorders were found for TSPAN14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN14 Gene

Publications for TSPAN14 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  2. TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS. (PMID: 26668317) Noy PJ … Tomlinson MG (The Journal of biological chemistry 2016) 3 4 60
  3. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. (PMID: 23035126) Haining EJ … Tomlinson MG (The Journal of biological chemistry 2012) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TSPAN14 Gene

Sources for TSPAN14 Gene

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