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Aliases for TSPAN14 Gene

Aliases for TSPAN14 Gene

  • Tetraspanin 14 2 3
  • Transmembrane 4 Superfamily Member 14 2 3 4
  • Tspan-14 3 4
  • DC-TM4F2 3 4
  • TM4SF14 3 4
  • Tetraspanin Similar To TM4SF9 3
  • Tetraspanin-14 3

External Ids for TSPAN14 Gene

Previous HGNC Symbols for TSPAN14 Gene

  • TM4SF14

Previous GeneCards Identifiers for TSPAN14 Gene

  • GC10P082205
  • GC10P076057

Summaries for TSPAN14 Gene

GeneCards Summary for TSPAN14 Gene

TSPAN14 (Tetraspanin 14) is a Protein Coding gene. An important paralog of this gene is TSPAN7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN14 Gene

Genomics for TSPAN14 Gene

Regulatory Elements for TSPAN14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSPAN14 Gene

Start:
80,454,166 bp from pter
End:
80,533,123 bp from pter
Size:
78,958 bases
Orientation:
Plus strand

Genomic View for TSPAN14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN14 Gene

Proteins for TSPAN14 Gene

  • Protein details for TSPAN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG11-TSN14_HUMAN
    Recommended name:
    Tetraspanin-14
    Protein Accession:
    Q8NG11
    Secondary Accessions:
    • A6NHE1
    • B4DHY6
    • D3DWD7
    • D3DWD8
    • Q567U7
    • Q9BU34
    • Q9H0U1

    Protein attributes for TSPAN14 Gene

    Size:
    270 amino acids
    Molecular mass:
    30691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN14 Gene

Proteomics data for TSPAN14 Gene at MOPED

Post-translational modifications for TSPAN14 Gene

No data available for DME Specific Peptides for TSPAN14 Gene

Domains for TSPAN14 Gene

Gene Families for TSPAN14 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

Q8NG11

UniProtKB/Swiss-Prot:

TSN14_HUMAN :
  • Q8NG11
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN14: view

Function for TSPAN14 Gene

Gene Ontology (GO) - Molecular Function for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN14: view

Animal Model Products

CRISPR Products

miRNA for TSPAN14 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN14

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSPAN14 Gene

Localization for TSPAN14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN14 Gene COMPARTMENTS Subcellular localization image for TSPAN14 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA --
GO:0097197 tetraspanin-enriched microdomain IEA --
genes like me logo Genes that share ontologies with TSPAN14: view

Pathways for TSPAN14 Gene

SuperPathways for TSPAN14 Gene

No Data Available

Interacting Proteins for TSPAN14 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361229%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000009180%0d%0a9606.ENSP00000327214%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q8NG11-TSN14_HUMAN ENSP00000361229 for TSPAN14 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045747 positive regulation of Notch signaling pathway IMP 23091066
GO:0051604 protein maturation IMP 23091066
GO:0090002 establishment of protein localization to plasma membrane IMP 23035126
genes like me logo Genes that share ontologies with TSPAN14: view

No data available for Pathways by source for TSPAN14 Gene

Transcripts for TSPAN14 Gene

Unigene Clusters for TSPAN14 Gene

Tetraspanin 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5:
SP6: -
SP7: - - - -
SP8:

Relevant External Links for TSPAN14 Gene

GeneLoc Exon Structure for
TSPAN14
ECgene alternative splicing isoforms for
TSPAN14

Expression for TSPAN14 Gene

mRNA expression in normal human tissues for TSPAN14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN14 Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN14 Gene

SOURCE GeneReport for Unigene cluster for TSPAN14 Gene Hs.718943

genes like me logo Genes that share expressions with TSPAN14: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN14 Gene

Orthologs for TSPAN14 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN14 35
  • 99.63 (n)
  • 100 (a)
TSPAN14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN14 35
  • 91.6 (n)
  • 98.15 (a)
TSPAN14 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN14 35
  • 91.6 (n)
  • 97.04 (a)
TSPAN14 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan14 35
  • 90.62 (n)
  • 97.41 (a)
Tspan14 16
Tspan14 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSPAN14 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN14 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan14 35
  • 89.88 (n)
  • 97.04 (a)
chicken
(Gallus gallus)
Aves TSPAN14 35
  • 75.68 (n)
  • 85.19 (a)
TSPAN14 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN14 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan14 35
  • 71.23 (n)
  • 80.37 (a)
zebrafish
(Danio rerio)
Actinopterygii tspan14 35
  • 68.03 (n)
  • 71.75 (a)
tspan14 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-12 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for TSPAN14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN14 Gene

ENSEMBL:
Gene Tree for TSPAN14 (if available)
TreeFam:
Gene Tree for TSPAN14 (if available)

Paralogs for TSPAN14 Gene

Selected SIMAP similar genes for TSPAN14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN14: view

Variants for TSPAN14 Gene

Sequence variations from dbSNP and Humsavar for TSPAN14 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs873257 -- 80,520,384(-) GCCAC(A/G)TGACC utr-variant-3-prime
rs873258 -- 80,520,204(-) CAGGA(A/G)CCTTC utr-variant-3-prime
rs873259 -- 80,520,171(-) CTGTG(A/G)CCACC utr-variant-3-prime
rs878651 -- 80,474,861(-) ATAAG(G/T)GGTCA intron-variant
rs878652 -- 80,474,831(-) AGAAA(A/C)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN14 Gene

Variant ID Type Subtype PubMed ID
nsv831923 CNV Loss 17160897
nsv831924 CNV Loss 17160897
nsv524518 CNV Loss 19592680
nsv469837 CNV Loss 16826518
esv28286 CNV Loss 19812545
esv2460472 CNV Deletion 19546169
esv2664515 CNV Deletion 23128226
esv6437 CNV Gain 19470904
nsv7354 CNV Loss 18451855

Relevant External Links for TSPAN14 Gene

HapMap Linkage Disequilibrium report
TSPAN14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN14 Gene

Disorders for TSPAN14 Gene

No disorders were found for TSPAN14 Gene.

No data available for UniProtKB/Swiss-Prot for TSPAN14 Gene

Publications for TSPAN14 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TSPAN14 Gene

Sources for TSPAN14 Gene

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