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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPAN14 Gene

protein-coding   GIFtS: 46
GCID: GC10P082205

tetraspanin 14

(Previous name: transmembrane 4 superfamily member 14 )
(Previous symbol: TM4SF14)
 Explore 1 disease affiliated with
TSPAN14 via our new
 Human Malady Compendium 
Biological research products
for TSPAN14
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tetraspanin 141 2     Tetraspanin Similar To TM4SF92
Transmembrane 4 Superfamily Member 141 2 3     Tetraspanin-141
DC-TM4F21 2 3     Tspan-143
TM4SF141 2 3     Tspan-143
MGC113521     

External Ids:    HGNC: 233031   Entrez Gene: 816192   Ensembl: ENSG000001082197   UniProtKB: Q8NG113   

Export aliases for TSPAN14 gene to outside databases

Previous GC identifer: GC10P076057


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPAN14 gene promoter:
         HEN1   ISGF-3   Pax-5   E2F   E2F-1   ARP-1   MyoD   LUN-1   Ik-3   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN14 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPAN14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.1   Ensembl cytogenetic band:  10q23.1   HGNC cytogenetic band: 10q23.1

TSPAN14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN14 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P082205:  view genomic region     (about GC identifiers)

Start:
82,213,922 bp from pter      End:
82,282,391 bp from pter
Size:
68,470 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSN14_HUMAN, Q8NG11 (See protein sequence)
Recommended Name: Tetraspanin-14  
Size: 270 amino acids; 30691 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A6NHE1 B4DHY6 D3DWD7 D3DWD8 Q567U7 Q9BU34 Q9H0U1
Alternative splicing: 3 isoforms:  Q8NG11-1   Q8NG11-2   Q8NG11-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSPAN14: NX_Q8NG11

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NG11

  • TSPAN14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121781.1  NP_112189.2  

    ENSEMBL proteins: 
     ENSP00000396270   ENSP00000418195   ENSP00000361233   ENSP00000361230   ENSP00000361237  
     ENSP00000361231   ENSP00000344076   ENSP00000361229  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TSPAN14

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    TSPAN14 for ontologies           About GeneDecksing



    TSPAN14 Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TSPAN14 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018499 Tetraspanin/Peripherin
     IPR018503 Tetraspanin_CS
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2

    Graphical View of Domain Structure for InterPro Entry Q8NG11

    ProtoNet protein and cluster: Q8NG11

    1 Blocks protein family: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN14_HUMAN, Q8NG11
    Similarity: Belongs to the tetraspanin (TM4SF) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN14
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN14 (see all 46):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-330-5p hsa-miR-199a-3p hsa-miR-29a hsa-miR-449a hsa-miR-149 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN14 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN14 (see all 4)
    OriGene shRNA RFP: TSPAN14
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN14

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/26 Interacting proteins for TSPAN14 (Q8NG112 ENSP000003612294) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAM10O146722MINT-8407185
    ANXA6P081332MINT-8407185
    C14orf166BQ0VAA22MINT-8407185
    CD19P153912MINT-8407185
    CD63P089622MINT-8407185
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSPAN14
    Search CenterWatch for drugs/clinical trials and news about TSPAN14 / TSN14 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSPAN14 gene (2 alternative transcripts): 
    NM_001128309.1  NM_030927.2  

    Unigene Cluster for TSPAN14:

    Tetraspanin 14
    Hs.718943  [show with all ESTs]
    Unigene Representative Sequence: NM_030927
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429989(uc001kcj.4 uc009xss.3 uc001kci.4) ENST00000481124
    ENST00000372160 ENST00000372157 ENST00000469149 ENST00000372164 ENST00000372158
    ENST00000341863 ENST00000372156 ENST00000265450

    miRNA
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    OriGene 3'-UTR Clone (see all 2): TSPAN14
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN14
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN14 (see all 46):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-330-5p hsa-miR-199a-3p hsa-miR-29a hsa-miR-449a hsa-miR-149 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN14 (see all 4)
    OriGene shRNA RFP: TSPAN14
    OriGene siRNA: TSPAN14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN14
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN14 (see all 3)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN14
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    Additional cDNA sequence: 

    AF311903.1 AK025157.1 AK026621.1 AK054854.1 AK055330.1 AK074558.1 AK295321.1 AL136638.1 
    AL359556.2 BC002920.2 BC093016.1 

    24 DOTS entries:

    DT.97835694  DT.95326747  DT.121298427  DT.100812348  DT.40130456  DT.100812351  DT.121298441  DT.100030891 
    DT.95326677  DT.100812350  DT.95346770  DT.95370181  DT.100812345  DT.100812349  DT.102832395  DT.121298496 
    DT.95230126  DT.100812346  DT.121298463  DT.121298465  DT.121298495  DT.95244216  DT.95255756  DT.95255907 

    24/440 AceView cDNA sequences (see all 440):

    BE901141 BI905852 BI752812 AI828706 BI754160 BM694271 AL519790 BU859492 
    AL553172 BM129250 BU752872 AL539537 BU629800 AA299953 BG119500 BX474656 
    AA299954 W67858 AK026621 CB069094 AA864643 BU597761 BU931726 AA137115 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN14 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
    SP1:                                -                                   -     -                 -                                       
    SP2:                                -           -                       -     -                 -                                       
    SP3:                                -                 -     -     -     -     -                 -                                       
    SP4:                                -           -     -     -     -     -     -                 -                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TSPAN14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSPAN14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCCAGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TSPAN14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TSPAN14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSPAN14

    SOURCE GeneReport for Unigene cluster: Hs.718943
        SABiosciences Custom PCR Arrays for TSPAN14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN14 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TSPAN141 tetraspanin 14 75.68(n)
    85.19(a)
      423624  NM_001031218.1  NP_001026389.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSPAN146
    --
    81(a)
    1 ↔ 1
    GL343233.1(1952537-1999131)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420228552   -- 74.74(n)    142022855 
    zebrafish
    (Danio rerio)
    Actinopterygii tspan141 tetraspanin 14 68.03(n)
    71.75(a)
      751700  NM_001045412.1  NP_001038877.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp26A6
    Tetraspanin 26A
    37(a)
    1 → many
    2L(6000228-6003738)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-126
    TetraSPanin family member (tsp-12)
    32(a)
    1 → many
    IV(10149141-10150582)


    ENSEMBL Gene Tree for TSPAN14 (if available)
    TreeFam Gene Tree for TSPAN14 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSPAN14 gene
    TSPAN52  TSPAN172  TSPAN152  TSPAN332  
    11 SIMAP similar genes for TSPAN14 using alignment to 4 protein entries:     TSN14_HUMAN (see all proteins):
    TM4SF17    TSPAN5    TSPAN17    TM4SF9    TSPAN33    TSPAN15
    CD63    TSPAN10    TSPAN4    TSPAN18    TSPAN9

    TSPAN14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1201 NCBI SNPs in TSPAN14 are shown (see all 1201    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906714301,2
    --82212082(+) CCAAGA/GCTCAA 2 -- us2k10--------
    rs1412491991,2
    --82212102(+) CATTCC/TTTGAC 2 -- us2k10--------
    rs760384381,2
    F,--82212131(+) ATGCTT/CTGGCC 2 -- us2k11Minor allele frequency- C:0.12WA 118
    rs1180187191,2
    --82212177(+) CCCTAG/AGCTTA 2 -- us2k11Minor allele frequency- A:0.01EA 120
    rs70782541,2
    C,F,A,H,--82212193(+) TCAGCT/CACACT 2 -- us2k113Minor allele frequency- C:0.30NS EA NA WA CSA 789
    rs1815512401,2
    --82212247(+) AAGGCA/GCCTAC 2 -- us2k10--------
    rs1854899991,2
    --82212262(+) CTCAGC/TGAGGA 2 -- us2k10--------
    rs1910217191,2
    --82212304(+) TCCTTA/GCTCTT 2 -- us2k10--------
    rs124131201,2
    C,F,H--82212502(+) ATCCCA/CCCATG 2 -- us2k15Minor allele frequency- C:0.00NS EA NA 422
    rs18701471,2
    C,F,A,H,--82212541(+) CTCAGT/ACAAAC 2 -- us2k125Minor allele frequency- A:0.33NS EA NA WA CSA 2413

    HapMap Linkage Disequilibrium report for TSPAN14 (82213922 - 82282391 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TSPAN14
         2 CNVs: 100994 2160
         2 Indels: 71063 60020

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN14
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TSPAN14 for disorders           About GeneDecksing

    1 disease for TSPAN14:    About MalaCards
    lung cancer


    Export disorders for TSPAN14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSPAN14 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TSPAN14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Identification of genes associated with non-small-cel l lung cancer promotion and progression. (PubMed id 19473719)1 Bankovic J....Tanic N. (2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81619 HGNC: 23303 AceView: DC-TM4F2 Ensembl:ENSG00000108219 euGenes: HUgn81619
    ECgene: TSPAN14 H-InvDB: TSPAN14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSPAN14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSPAN14 gene:
    Search GeneIP for patents involving TSPAN14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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