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TSPAN14 Gene

protein-coding   GIFtS: 45
GCID: GC10P082205

Tetraspanin 14

(Previous name: transmembrane 4 superfamily member 14)
(Previous symbol: TM4SF14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetraspanin 141 2     Tetraspanin Similar To TM4SF92
Transmembrane 4 Superfamily Member 141 2 3     tetraspanin-142
TM4SF141 2 3     tspan-142
DC-TM4F22 3     Tspan-143

External Ids:    HGNC: 233031   Entrez Gene: 816192   Ensembl: ENSG000001082197   UniProtKB: Q8NG113   

Export aliases for TSPAN14 gene to outside databases

Previous GC identifer: GC10P076057


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSPAN14 Gene:
TSPAN14 (tetraspanin 14) is a protein-coding gene. An important paralog of this gene is CD151.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN14 gene promoter:
         HEN1   ISGF-3   Pax-5   E2F   E2F-1   ARP-1   MyoD   LUN-1   Ik-3   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN14 promoter sequence
   Search Chromatin IP Primers for TSPAN14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.1   Ensembl cytogenetic band:  10q23.1   HGNC cytogenetic band: 10q23.1

TSPAN14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN14 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P082205:  view genomic region     (about GC identifiers)

Start:
82,213,922 bp from pter      End:
82,292,879 bp from pter
Size:
78,958 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSN14_HUMAN, Q8NG11 (See protein sequence)
Recommended Name: Tetraspanin-14  
Size: 270 amino acids; 30691 Da
Secondary accessions: A6NHE1 B4DHY6 D3DWD7 D3DWD8 Q567U7 Q9BU34 Q9H0U1
Alternative splicing: 3 isoforms:  Q8NG11-1   Q8NG11-2   Q8NG11-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSPAN14: NX_Q8NG11

Explore proteomics data for TSPAN14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys265
  • Glycosylation2 at Asn169
  • Modification sites at PhosphoSitePlus

  • See TSPAN14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121781.1  NP_112189.2  

    ENSEMBL proteins: 
     ENSP00000396270   ENSP00000418195   ENSP00000361230   ENSP00000361237   ENSP00000361231  
     ENSP00000344076   ENSP00000361229  

    TSPAN14 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TSPAN14

     
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    Abcam antibodies for TSPAN14
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    LSBio Antibodies in human, mouse, rat for TSPAN14

    TSPAN14 Assay Products:

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    Cloud-Clone Corp. ELISAs for TSPAN14
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    Search eBioscience for ELISAs for TSPAN14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry Q8NG11

    ProtoNet protein and cluster: Q8NG11

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN14_HUMAN, Q8NG11
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with TSPAN14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPAN14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSPAN14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPAN14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPAN14

    miRNA
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    miRTarBase miRNAs that target TSPAN14:
    hsa-mir-96-5p (MIRT027896), hsa-mir-34a-5p (MIRT025376), hsa-mir-769-3p (MIRT039092), hsa-mir-155-5p (MIRT020709), hsa-mir-24-3p (MIRT030452)

    Block miRNA regulation of human, mouse, rat TSPAN14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN14 (see all 46):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-330-5p hsa-miR-199a-3p hsa-miR-29a hsa-miR-449a hsa-miR-149 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSPAN14
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN14

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TSPAN14 (see all 13)
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    GenScript: all cDNA clones in your preferred vector (see all 2): TSPAN14 (NM_030927)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN14

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN14_HUMAN, Q8NG11: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TSPAN14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN14
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN14

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for TSPAN14 (Q8NG112 ENSP000003612294) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAM10O146722MINT-8407185
    ANXA6P081332MINT-8407185
    CD19P153912MINT-8407185
    CD63P089622MINT-8407185
    CD81P600332MINT-8407185
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN14 (TSN14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPAN14 gene (2 alternative transcripts): 
    NM_001128309.1  NM_030927.2  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429989(uc001kcj.4 uc009xss.3 uc001kci.4) ENST00000481124
    ENST00000372157 ENST00000469149 ENST00000372164 ENST00000372158 ENST00000341863
    ENST00000372156 ENST00000265450
    miRNA
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    Block miRNA regulation of human, mouse, rat TSPAN14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPAN14 (see all 46):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-330-5p hsa-miR-199a-3p hsa-miR-29a hsa-miR-449a hsa-miR-149 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSPAN14
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN14
    Clone
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    OriGene clones in human, mouse for TSPAN14 (see all 13)
    OriGene ORF clones in mouse, rat for TSPAN14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TSPAN14 (NM_030927)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN14
    Primer
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    OriGene qPCR primer pairs and template standards for TSPAN14
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN14
      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN14
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN14

    Selected AceView cDNA sequences (see all 440):

    AA299954 AJ706037 AK074558 BU846339 BE901141 BI905852 AL519790 BQ024398 
    BI752812 BQ071119 BU931342 BM911935 BM887950 AA299953 BX458478 BU931726 
    CR612301 AW339191 BQ923322 AA437080 BE671521 AI275859 BQ232406 BM558974 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN14 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
    SP1:                                -                                   -     -                 -                                       
    SP2:                                -           -                       -     -                 -                                       
    SP3:                                -                 -     -     -     -     -                 -                                       
    SP4:                                -           -     -     -     -     -     -                 -                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TSPAN14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCAGGGC
    TSPAN14 Expression
    About this image


    TSPAN14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Crest (Gastrulation Derivatives)
             Cranial Neural Crest Cells Branchial Arch 1
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Head Mesenchyme (Muscoskeletal System)
             Cranial Neural Crest Cells Branchial Arch 1
     
     Ovary (Reproductive System)
    TSPAN14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN14 Protein Expression
        Custom PCR Arrays for TSPAN14
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    QuantiFast Probe-based Assays in human, mouse, rat TSPAN14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN14 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan141 , 5 tetraspanin 141, 5 90.62(n)1
    97.41(a)1
      14 (22.36 cM)5
    525881  NM_145928.11  NP_666040.11 
     409064455 
    chicken
    (Gallus gallus)
    Aves TSPAN141 tetraspanin 14 75.68(n)
    85.19(a)
      423624  NM_001031218.1  NP_001026389.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSPAN146
    tetraspanin 14
    81(a)
    1 ↔ 1
    GL343233.1(1952537-1999131)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420228552   -- 74.74(n)    142022855 
    zebrafish
    (Danio rerio)
    Actinopterygii tspan141 tetraspanin 14 68.03(n)
    71.75(a)
      751700  NM_001045412.1  NP_001038877.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp26A6
    Tetraspanin 26A
    36(a)
    1 → many
    2L(6000228-6003738)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-126
    Protein TSP-12 (tsp-12) mRNA, complete cds
    33(a)
    1 → many
    IV(10149163-10150604) WBGene00006638


    ENSEMBL Gene Tree for TSPAN14 (if available)
    TreeFam Gene Tree for TSPAN14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN14 gene
    CD1512  TSPAN52  TSPAN102  TSPAN172  TSPAN332  TSPAN62  TSPAN32  CD632  
    TSPAN152  TSPAN72  TSPAN112  ENSG000002503492  
    10 SIMAP similar genes for TSPAN14 using alignment to 3 protein entries:     TSN14_HUMAN (see all proteins):
    TM4SF17    TSPAN5    TSPAN17    TM4SF9    TSPAN33    TSPAN15
    CD63    TSPAN10    TSPAN4    TSPAN18

    Find genes that share paralogs with TSPAN14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN14 (see all 1457)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906714301,2
    --82212082(+) CCAAGA/GCTCAA 2 -- us2k10--------
    rs1412491991,2
    --82212102(+) CATTCC/TTTGAC 2 -- us2k10--------
    rs760384381,2
    F--82212131(+) ATGCTT/CTGGCC 2 -- us2k11Minor allele frequency- C:0.12WA 118
    rs1180187191,2
    F--82212177(+) CCCTAG/AGCTTA 2 -- us2k11Minor allele frequency- A:0.01EA 120
    rs70782541,2
    C,F,A,H--82212193(+) tcagcT/Cacact 2 -- us2k113Minor allele frequency- C:0.30NS EA NA WA CSA 789
    rs1815512401,2
    --82212247(+) AAGGCA/GCCTAC 2 -- us2k10--------
    rs1854899991,2
    --82212262(+) CTCAGC/TGAGGA 2 -- us2k10--------
    rs1910217191,2
    --82212304(+) TCCTTA/GCTCTT 2 -- us2k10--------
    rs124131201,2
    C,F,H--82212502(+) ATCCCA/CCCATG 2 -- us2k15Minor allele frequency- C:0.00NS EA NA 422
    rs18701471,2
    C,F,A,H--82212541(+) ctcagT/Acaaac 2 -- us2k125Minor allele frequency- A:0.33NS EA NA WA CSA 2413

    HapMap Linkage Disequilibrium report for TSPAN14 (82213922 - 82292879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TSPAN14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2460472CNV Deletion19546169
    esv2664515CNV Deletion23128226
    nsv524518CNV Loss19592680
    esv28286CNV Loss19812545
    nsv7354CNV Loss18451855
    nsv469837CNV Loss16826518
    nsv831924CNV Loss17160897
    nsv831923CNV Loss17160897
    esv6437CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPAN14
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN14 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TSPAN14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    6. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (Hum. Mol. Genet. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81619 HGNC: 23303 AceView: DC-TM4F2 Ensembl:ENSG00000108219 euGenes: HUgn81619
    ECgene: TSPAN14 H-InvDB: TSPAN14

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPAN14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPAN14 gene:
    Search GeneIP for patents involving TSPAN14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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