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Aliases for TSPAN14 Gene

Aliases for TSPAN14 Gene

  • Tetraspanin 14 2 3 5
  • Transmembrane 4 Superfamily Member 14 2 3 4
  • Tspan-14 3 4
  • DC-TM4F2 3 4
  • TM4SF14 3 4
  • Tetraspanin Similar To TM4SF9 3

External Ids for TSPAN14 Gene

Previous HGNC Symbols for TSPAN14 Gene

  • TM4SF14

Previous GeneCards Identifiers for TSPAN14 Gene

  • GC10P082205
  • GC10P076057
  • GC10P080487

Summaries for TSPAN14 Gene

GeneCards Summary for TSPAN14 Gene

TSPAN14 (Tetraspanin 14) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is ENSG00000250349.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN14 Gene

Genomics for TSPAN14 Gene

Regulatory Elements for TSPAN14 Gene

Promoters for TSPAN14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN14 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN14 Gene

Chromosome:
10
Start:
80,454,166 bp from pter
End:
80,533,123 bp from pter
Size:
78,958 bases
Orientation:
Plus strand

Genomic View for TSPAN14 Gene

Genes around TSPAN14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN14 Gene

Proteins for TSPAN14 Gene

  • Protein details for TSPAN14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG11-TSN14_HUMAN
    Recommended name:
    Tetraspanin-14
    Protein Accession:
    Q8NG11
    Secondary Accessions:
    • A6NHE1
    • B4DHY6
    • D3DWD7
    • D3DWD8
    • Q567U7
    • Q9BU34
    • Q9H0U1

    Protein attributes for TSPAN14 Gene

    Size:
    270 amino acids
    Molecular mass:
    30691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPAN14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPAN14 Gene

Proteomics data for TSPAN14 Gene at MOPED

Post-translational modifications for TSPAN14 Gene

No data available for DME Specific Peptides for TSPAN14 Gene

Domains & Families for TSPAN14 Gene

Gene Families for TSPAN14 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NG11

UniProtKB/Swiss-Prot:

TSN14_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN14: view

Function for TSPAN14 Gene

genes like me logo Genes that share phenotypes with TSPAN14: view

Animal Model Products

miRNA for TSPAN14 Gene

miRTarBase miRNAs that target TSPAN14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN14 Gene

Localization for TSPAN14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN14 Gene COMPARTMENTS Subcellular localization image for TSPAN14 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23091066
GO:0005887 integral component of plasma membrane IBA --
GO:0097197 tetraspanin-enriched microdomain IEA --
genes like me logo Genes that share ontologies with TSPAN14: view

Pathways & Interactions for TSPAN14 Gene

SuperPathways for TSPAN14 Gene

No Data Available

Interacting Proteins for TSPAN14 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361229%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000009180%0d%0a9606.ENSP00000327214%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q8NG11-TSN14_HUMAN ENSP00000361229 for TSPAN14 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for TSPAN14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN14: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN14 Gene

Drugs & Compounds for TSPAN14 Gene

No Compound Related Data Available

Transcripts for TSPAN14 Gene

Unigene Clusters for TSPAN14 Gene

Tetraspanin 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5:
SP6: -
SP7: - - - -
SP8:

Relevant External Links for TSPAN14 Gene

GeneLoc Exon Structure for
TSPAN14
ECgene alternative splicing isoforms for
TSPAN14

Expression for TSPAN14 Gene

mRNA expression in normal human tissues for TSPAN14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN14 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for TSPAN14 Gene

This gene is overexpressed in Cerebrospinal fluid (35.7) and Esophagus (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN14 Gene



SOURCE GeneReport for Unigene cluster for TSPAN14 Gene Hs.718943

genes like me logo Genes that share expression patterns with TSPAN14: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPAN14 Gene

Orthologs for TSPAN14 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSPAN14 35
  • 91.6 (n)
  • 98.15 (a)
TSPAN14 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN14 35
  • 91.6 (n)
  • 97.04 (a)
TSPAN14 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan14 35
  • 90.62 (n)
  • 97.41 (a)
Tspan14 16
Tspan14 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSPAN14 35
  • 99.63 (n)
  • 100 (a)
TSPAN14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan14 35
  • 89.88 (n)
  • 97.04 (a)
oppossum
(Monodelphis domestica)
Mammalia TSPAN14 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN14 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN14 35
  • 75.68 (n)
  • 85.19 (a)
TSPAN14 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN14 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan14 35
  • 71.23 (n)
  • 80.37 (a)
zebrafish
(Danio rerio)
Actinopterygii tspan14 35
  • 68.03 (n)
  • 71.75 (a)
tspan14 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-12 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for TSPAN14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN14 Gene

ENSEMBL:
Gene Tree for TSPAN14 (if available)
TreeFam:
Gene Tree for TSPAN14 (if available)

Paralogs for TSPAN14 Gene

(10) SIMAP similar genes for TSPAN14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN14: view

Variants for TSPAN14 Gene

Sequence variations from dbSNP and Humsavar for TSPAN14 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs878651 -- 80,474,861(-) ATAAG(G/T)GGTCA intron-variant
rs878652 -- 80,474,831(-) AGAAA(A/C)CCCAA intron-variant
rs882682 -- 80,510,276(+) TCTAT(A/G)ATTCA intron-variant
rs1140376 -- 80,483,913(+) tctca(A/C/T)aaaaa intron-variant
rs1052605 -- 80,518,580(+) TGAGC(A/C)AGTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TSPAN14 Gene

Variant ID Type Subtype PubMed ID
nsv831923 CNV Loss 17160897
nsv831924 CNV Loss 17160897
nsv524518 CNV Loss 19592680
nsv469837 CNV Loss 16826518
esv28286 CNV Loss 19812545
esv2460472 CNV Deletion 19546169
esv2664515 CNV Deletion 23128226
esv6437 CNV Gain 19470904
nsv7354 CNV Loss 18451855

Variation tolerance for TSPAN14 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN14 Gene

HapMap Linkage Disequilibrium report
TSPAN14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN14 Gene

Disorders for TSPAN14 Gene

Relevant External Links for TSPAN14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN14

No disorders were found for TSPAN14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN14 Gene

Publications for TSPAN14 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 3
  3. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. (PMID: 23035126) Haining E.J. … Tomlinson M.G. (J. Biol. Chem. 2012) 3
  4. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E. … Rubinstein E. (J. Cell Biol. 2012) 3
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3

Products for TSPAN14 Gene

Sources for TSPAN14 Gene

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