TSPAN13 Gene
protein-coding GIFtS : 48
GCID: GC07 P016759
tetraspanin 13 (Previous name: transmembrane 4 superfamily member 13 ) (Previous symbol: TM4SF13 )
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Aliasesfor TSPAN13 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tetraspanin 13 1 2 Tetraspan NET-62 3 Transmembrane 4 Superfamily Member 131 2 3 Tetraspanin-131 TM4SF131 2 3 Transmembrane 4 Superfamily Member Tetraspan NET-62 NET62 3 5 Tspan-133 NET-61 2 Tspan-133
Export aliases for TSPAN13 gene to outside databases Previous GC identifer: GC07P016567
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Summariesfor TSPAN13 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TSPAN13 : The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (provided by RefSeq, Jul 2008) Gene Wiki entry for TSPAN13
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Genomic Viewsfor TSPAN13 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TSPAN13 gene promoter: Max1 Sp1 AML1a NCX/Ncx GATA-1 AREB6 USF-1 FOXO4 SEF-1 (1) c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for TSPAN13 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TSPAN13
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p21.1 Ensembl cytogenetic band: 7p21.1 HGNC cytogenetic band: 7p21.2 TSPAN13 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P016759: view genomic region
(about GC identifiers )
Start:
16,793,160 bp from pter
End:
16,824,161 bp from pter
Size:
31,002 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 16,847,009-16,877,818
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Proteinsfor TSPAN13 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TSN13_HUMAN, O95857 (See
protein sequence )Recommended Name: Tetraspanin-13 Size : 204 amino acids; 22147 Da
Subcellular location : Membrane; Multi-pass membrane protein (Probable)Explore the universe of human proteins at neXtProt for TSPAN13: NX_O95857 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O95857 TSPAN13 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_055214.1 ENSEMBL proteins: ENSP00000262067 Human Recombinant Protein Products for TSPAN13: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
TSPAN13 for ontologies About GeneDecksing TSPAN13 Antibody Products: Assay Products for TSPAN13:
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Protein
Domains / Familiesfor TSPAN13 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TSPAN13 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O95857 ProtoNet protein and cluster: O95857
1 Blocks protein family : IPB000301 Transmembrane four family signature UniProtKB/Swiss-Prot: TSN13_HUMAN, O95857 Similarity : Belongs to the tetraspanin (TM4SF) family
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Functionfor TSPAN13 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Phenotypes: 2 GenomeRNAi human phenotypes for TSPAN13 : 1 MGI phenotypic allele for Tspan13 (no phenotypes)
TSPAN13 for phenotypes About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN13 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN13 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPAN13 (NM_014399 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN13 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN13
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN13
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Pathways & Interactionsfor TSPAN13 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN13 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TSPAN13 (ENSP00000262067 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor TSPAN13 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TSPAN13 Search CenterWatch for drugs/clinical trials and news about TSPAN13 / TSN13
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Transcriptsfor TSPAN13 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TSPAN13 gene: NM_014399.3 Unigene Cluster for TSPAN13:
Tetraspanin 13 Hs.364544 [show with all ESTs ] Unigene Representative Sequence: AK128509 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000262067 (uc003stq.3 ) ENST00000466195 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN13 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN13 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPAN13 (NM_014399 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN13 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN13
Additional cDNA sequence: AF100759.1 AF120265.1 AK026587.1 AK075475.1 AK093487.1 AK128509.1 AK316595.1 AY358995.1 BC033863.1 BX647338.1 CR542107.1
7 DOTS entries : DT.447575 DT.40281706
DT.100036993 DT.100817966 DT.100817973 DT.121112183 DT.121112193 24/372 AceView cDNA sequences (see all 372 ):
AA558969 CB996673 BQ011525 BF971123 CR612760 AK128509 CR602288 R62471 CA772266 CB112514 F13055 CR600961 CR591620 AY358995 CA336649 CR598804 BU625138 BM753869 CR612419 BG778224 T32004 CR610283 AV726823 CB121048 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN13 About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 SP1 :                     SP2 :       -   -            
ECgene alternative splicing isoforms for TSPAN13
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Expression for TSPAN13 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TSPAN13 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAGTTCTCAAbout this image TSPAN13 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See TSPAN13 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSPAN13 SOURCE GeneReport for Unigene cluster: Hs.364544 SABiosciences Expression via Pathway-Focused PCR Array including TSPAN13 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPAN13Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TSPAN13 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPAN13 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPAN13 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN13
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Orthologsfor TSPAN13 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TSPAN13 gene from 5/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for TSPAN13 (if available)TreeFam Gene Tree for TSPAN13 (if available)
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Paralogsfor TSPAN13 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TSPAN13 gene TSPAN31 2 2 SIMAP similar genes for TSPAN13 using alignment to 1 protein entry: TSN13_HUMAN :TM4SF13 TSPAN31
TSPAN13 for paralogs About GeneDecksing
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Genomic Variantsfor TSPAN13 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TSPAN13 (16793160 - 16824161 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TSPAN13 1 Indel : 52179
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPAN13
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Disorders
/ Diseasesfor TSPAN13 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TSPAN13 for disorders About GeneDecksing
OMIM gene information: 613139
OMIM disorders : --3 diseases for TSPAN13 : About MalaCards prostate cancer breast cancer prostatitis Export disorders for TSPAN13 gene to outside databases
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Publicationsfor TSPAN13 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TSPAN13 gene, integrated from 9 sources (see all 17 ): (articles sorted by number of sources associating them with TSPAN13) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946) 1 , 2 Hu R.-M.... Chen J.-L. (2000) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer. (PubMed id 19148481) 1 Arencibia J.M....Bonnin A. (2009) The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. (PubMed id 17486367) 1 Huang H....Geradts J. (2007) Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743) 1 Otsuki T....Isogai T. (2005) Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. (PubMed id 15958618) 1 Huang H....Geradts J. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004)
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External Searches for TSPAN13 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TSPAN13 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TSPAN13 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TSPAN13 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TSPAN13 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TSPAN13 gene: Search GeneIP for patents involving TSPAN13 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TSPAN13 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TSPAN13 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TSPAN13 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPAN13 OriGene Protein Over-expression Lysate for TSPAN13 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TSPAN13 OriGene 3'-UTR Clone for TSPAN13 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN13 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN13 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TSPAN13 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TSPAN13 OriGene Custom Protein Services for TSPAN13 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN13 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPAN13 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TSPAN13 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TSPAN13 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPAN13 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPAN13
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TSPAN13 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN13
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN13
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