TSPAN12 Gene
protein-coding GIFtS: 52
GCID: GC07M120427
|
|
tetraspanin 12(Previous name: transmembrane 4 superfamily member 12 )
(Previous symbol: TM4SF12)
| |
Aliases
for TSPAN12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetraspanin 121 2 | | Tetraspan NET-22 3 | | Transmembrane 4 Superfamily Member 121 2 3 | | EVR52 5 | | TM4SF121 2 3 | | Tetraspanin-121 | | NET22 3 5 | | Tspan-123 | | NET-21 2 | | Tspan-123 |
Export aliases for TSPAN12 gene to outside databasesPrevious GC identifers: GC07M120022 GC07M120214 GC07M114790 |
Summaries
for TSPAN12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSPAN12:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,growth and motility. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TSN12_HUMAN, O95859Function: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization byregulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization andsubsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediatedtranscriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it doesnot activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that alsopromote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such asADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). ActivatesMMP14/MT1-MMP-dependent cleavage activity
|
Genomic Views
for TSPAN12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSPAN12 gene promoter:
HFH-3 Pax-6 FOXD3 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 HNF-1A GATA-1 FOXI1 HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPAN12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.31 Ensembl cytogenetic band: 7q31.31 HGNC cytogenetic band: 7q31.31TSPAN12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M120427: view genomic region
(about GC identifiers)
Start:
|
120,427,374 bp from pter |
End:
|
120,498,456 bp from pter |
Size:
|
71,083 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 119,822,450-119,893,269 |
|
Proteins
for TSPAN12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSN12_HUMAN, O95859 (See
protein sequence)Recommended Name: Tetraspanin-12 Size: 305 amino acids; 35383 Da
Subunit: Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP) (By similarity). Interacts (whenpalmitoylated) with ADAM10. Interacts with MMP14/MT1-MMP
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A4D0V8 B4DRG6 Q549U9 Q8N5Y0Alternative splicing: 2 isoforms: O95859-1 O95859-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TSPAN12: NX_O95859
Post-translational modifications:
Palmitoylated; required for interaction with ADAM10. The precise position of palmitoylated residues is unclear andoccurs either on Cys-9, Cys-12 and/or Cys-831
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95859
TSPAN12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036470.1
ENSEMBL proteins: ENSP00000222747 ENSP00000397411 ENSP00000397699 ENSP00000411158 ENSP00000399059 ENSP00000404942 ENSP00000388819
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TSPAN12 for ontologies About GeneDecksing
TSPAN12 Antibody Products:
Assay Products for TSPAN12: |
Protein
Domains /
Families
for TSPAN12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPAN12 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95859ProtoNet protein and cluster: O95859 1 Blocks protein family: IPB000301 Transmembrane four family signature
UniProtKB/Swiss-Prot: TSN12_HUMAN, O95859Similarity: Belongs to the tetraspanin (TM4SF) family |
Function
for TSPAN12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSN12_HUMAN, O95859Function: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization byregulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization andsubsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediatedtranscriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it doesnot activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that alsopromote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such asADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). ActivatesMMP14/MT1-MMP-dependent cleavage activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSPAN12 (NM_012338) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN12 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042813 | NOT Wnt-activated receptor activity |
ISS | -- |
TSPAN12 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tspan12tm1Lex for TSPAN12
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tspan12):
TSPAN12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TSPAN12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN12
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for TSPAN12 (O958593 ENSP000002227474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001525 | angiogenesis |
IEA | -- | | GO:0007166 | cell surface receptor signaling pathway |
ISS | -- | | GO:0010842 | retina layer formation |
ISS | -- | | GO:0045765 | regulation of angiogenesis |
ISS | -- |
TSPAN12 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSPAN12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSPAN12
Search CenterWatch for drugs/clinical trials and news about TSPAN12 / TSN12
|
Transcripts
for TSPAN12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSPAN12 gene: NM_012338.3 Unigene Cluster for TSPAN12: Tetraspanin 12 Hs.16529 [show with all ESTs]Unigene Representative Sequence: NM_0123387 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000222747(uc010lkj.3 uc003vjk.3) ENST00000450414 ENST00000415871
ENST00000441017 ENST00000433758 ENST00000424710 ENST00000430985
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSPAN12 (NM_012338) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN12 |
Additional cDNA sequence: AF124522.1 AK299247.1 AK307161.1 AK312239.1 AY358703.1 BC031265.1 9 DOTS entries: DT.112725 DT.110079 DT.121107354 DT.121107378 DT.121107384 DT.121107361 DT.100028639 DT.121107371 DT.99956040 24/98 AceView cDNA sequences (see all 98): BM712366 CD656678 AY358703 BF002783 AI810992 AI050958 AW303290 BU688134 BF446201 AI283160 AI262216 AA227446 BM723162 AI337043 BF338835 BM760080 BQ012582 AI686122 AA570707 CD678290 AI056699 BG644291 NM_012338 AA227513
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN12 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSPAN12
|
Expression
for TSPAN12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPAN12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACAATTTA
About this image
See TSPAN12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPAN12
SOURCE GeneReport for Unigene cluster: Hs.16529
SABiosciences Custom PCR Arrays for TSPAN12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN12 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN12 |
Orthologs
for TSPAN12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSPAN12 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for TSPAN12 (if available)
TreeFam Gene Tree for TSPAN12 (if available) |
Paralogs
for TSPAN12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSPAN12 gene
3 SIMAP similar genes for TSPAN12 using alignment to 6 protein entries: TSN12_HUMAN (see all proteins):BTCC-1 CD9 TSPAN4
TSPAN12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSPAN12
PGOHUM00000244153
|
Genomic Variants
for TSPAN12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSPAN12 (120427374 - 120498456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSPAN12: --
Human Gene Mutation Database (HGMD): TSPAN12
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN12 |
|
Disorders
/ Diseases
for TSPAN12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPAN12 for disorders About GeneDecksing
OMIM gene information: 613138
OMIM disorders: 613310
UniProtKB/Swiss-Prot: TSN12_HUMAN, O95859
Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5 (EVR5) [MIM:613310]. It is a disorderof the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to anavascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be inducedby hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates andbleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, evenwithin the same family. Patients with mild forms of the disease are asymptomatic, and their only disease relatedabnormality is an arc of avascular retina in the extreme temporal periphery. Note=TSPAN12 dominant and recessivemutations have been identified in patients with exudative vitreoretinopathy. Patients with mutations in both allelesof TSPAN12 have severe exudative vitreoretinopathy or retinal dysplasia. These mutations appear to result in a milderphenotype in heterozygous mutation carriers (PubMed:22427576)
9  diseases for TSPAN12: About MalaCardsexudative vitreoretinopathy 5 exudative vitreoretinopathy autism spectrum disorder vitreoretinopathy
coats disease retinal detachment retinopathy of prematurity retinitis
blindness
1 disease from the University of Copenhagen DISEASES database for TSPAN12:Exudative vitreoretinopathy Human Genome Epidemiology (HuGE) Navigator: TSPAN12 (2 documents)
Export disorders for TSPAN12 gene to outside databases
|
Publications
for TSPAN12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPAN12 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with TSPAN12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Recessive mutations in TSPAN12 cause retinal dysplasia and severe familial exudative vitreoretinopathy (FEVR). (PubMed id 22427576)1, 2 Poulter J.A....Toomes C. (2012)
- Mutations in TSPAN12 cause autosomal-dominant familia l exudative vitreoretinopathy. (PubMed id 20159112)1, 2 Poulter J.A....Toomes C. (2010)
- Next-generation sequencing of a 40 Mb linkage interva l reveals TSPAN12 mutations in patients with familial exudative vitreoretinopat hy. (PubMed id 20159111)1, 2 Nikopoulos K....Collin R.W. (2010)
- Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. (PubMed id 19587294)1, 2 Xu D.... Hemler M.E. (2009)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Sequence and expression of seven new tetraspans. (PubMed id 10719184)1, 2 Serru V.... Rubinstein E. (2000)
- Submicroscopic deletion in 7q31 encompassing CADPS2 a nd TSPAN12 in a child with autism spectrum disorder and PHPV. (PubMed id 21626674)1 Okamoto N....Yamamoto T. (2011)
- Differential expression of miRNA-146a-regulated inflam matory genes in human primary neural, astroglial and microglial cells. (PubMed id 21640790)1 Li Y.Y....Lukiw W.J. (2011)
|
External Searches for TSPAN12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSPAN12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPAN12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPAN12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSPAN12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSPAN12 gene:
Search GeneIP for patents involving TSPAN12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPAN12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSPAN12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN12 | | | OriGene Protein Over-expression Lysate for TSPAN12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSPAN12 | | OriGene 3'-UTR Clone for TSPAN12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSPAN12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSPAN12 | | OriGene Custom Protein Services for TSPAN12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN12 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TSPAN12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TSPAN12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN12 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSPAN12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN12 |
|
|
|
|
