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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TSPAN11 Gene

protein-coding GIFtS: 39
GCID: GC12P031079

tetraspanin 11

Search for TSPAN11
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tetraspanin 11¹ ²
VSSW1971²
Tetraspanin-11¹
Tspan-11³
Tspan-11³

External Ids:	HGNC: 30795¹	Entrez Gene: 441631²	Ensembl: ENSG00000110900⁷	UniProtKB: A1L157³

Export aliases for TSPAN11 gene to outside databases

Previous GC identifers: GC12P030985 GC12P030844

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TSPAN11 gene promoter:
TBP HOXA3 SREBP-1c c-Ets-1 SREBP-1b C/EBPalpha Evi-1 SREBP-1a Cart-1 RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TSPAN11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21 Ensembl cytogenetic band: 12p11.21 HGNC cytogenetic band: 12p11.21

TSPAN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN11 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P031079: view genomic region (about GC identifiers)

Start:	31,079,362 bp from pter	End:	31,149,537 bp from pter
Size:	70,176 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSN11_HUMAN, A1L157 (See protein sequence)

Recommended Name: Tetraspanin-11

Size: 253 amino acids; 28245 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: A1L158 B2RUX6

Explore the universe of human proteins at neXtProt for TSPAN11: NX_A1L157

TSPAN11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073978.1

ENSEMBL proteins:

ENSP00000443890 ENSP00000437403 ENSP00000445503 ENSP00000261177 ENSP00000439895

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	Uscn Proteins for TSPAN11

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TSPAN11 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TSPAN11 for domains About GeneDecksing

3 InterPro domains/families:

IPR018499 Tetraspanin/Peripherin

IPR000301 Tetraspanin

IPR008952 Tetraspanin_EC2

Graphical View of Domain Structure for InterPro Entry A1L157

ProtoNet protein and cluster: A1L157

UniProtKB/Swiss-Prot: TSN11_HUMAN, A1L157

Similarity: Belongs to the tetraspanin (TM4SF) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TSPAN11

1 Interacting protein for TSPAN11 (A1L157³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DYNC2LI1	Q8TCX1³	I2D: score=2

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSPAN11
Search CenterWatch for drugs/clinical trials and news about TSPAN11 / TSN11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPAN11 gene:

NM_001080509.2

Unigene Cluster for TSPAN11:

Tetraspanin 11

Hs.505141 [show with all ESTs]

Unigene Representative Sequence: NM_001080509

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000545802 ENST00000546076 ENST00000535215 ENST00000261177(uc010sju.2 uc001rjp.3 uc010sjv.2)

ENST00000544427

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Additional cDNA sequence:

AK024399.1 AK293947.1 AK300920.1 AY358804.1 BC084571.1 BC127660.1 BC127661.1 BC146917.1

BC146922.1

4 DOTS entries:

DT.312099 DT.91999418 DT.121170471 DT.97776668

24/59 AceView cDNA sequences (see all 59):

BE858239 BM984757 AA625842 AI571653 BM717379 BG939653 AA621502 AW073303

AY358804 AI928682 AI334210 AI377796 BQ183742 BU181963 AI634403 BG329113

AI337607 AW298258 BI850142 BF529759 BQ893893 BQ717126 BI915938 AW051395

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN11 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7
SP1:			-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for TSPAN11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPAN11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATGATAA

About this image

TSPAN11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See TSPAN11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPAN11

SOURCE GeneReport for Unigene cluster: Hs.505141

SABiosciences Custom PCR Arrays for TSPAN11

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TSPAN11 gene from 3/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	tspan11¹	tetraspanin 11	71.41(n) 72.76(a)		564029 NM_001045037.1 NP_001038502.1
fruit fly (Drosophila melanogaster)	Insecta	Tsp74F¹	Tetraspanin 74F	48.48(n) 34.09(a)		39995 NM_079408.5 NP_524132.1
worm (Caenorhabditis elegans)	Secernentea	tsp-8⁶ tsp-9⁶	TetraSPanin family member (tsp-9)	21(a) 18(a)	possible ortholog possible ortholog	X(14726556-14729412) X(1246012-1247494)

ENSEMBL Gene Tree for TSPAN11 (if available)
TreeFam Gene Tree for TSPAN11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TSPAN11 gene

CD151² TSPAN1² CD37² TSPAN6² TSPAN9² TSPAN3² CD63² CD53²

CD82² TSPAN18² TSPAN7² TSPAN4² ENSG00000250349² TSPAN8²

18 SIMAP similar genes for TSPAN11 using alignment to 4 protein entries: TSN11_HUMAN (see all proteins):

CD151 CD82 CD63 TSPAN18 TSPAN3 TSPAN4

CD81 TSPAN6 TSPAN9 TSPAN8 TM4SF2 TSPAN1

TSPAN7 CD53 TSPAN17 CD9 TM4SF9 TSPAN5

TSPAN11 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TSPAN11
PGOHUM00000258609 PGOHUM00000258610

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180961304^1,2		--	31077859(+)	`GAGATA/GGAGAT`	1	--	us2k¹		0	--	--	--	--
rs139405718^1,2		--	31077866(+)	`AGATGA/GTATGT`	1	--	us2k¹		0	--	--	--	--
rs185241665^1,2		--	31077968(+)	`TTTCCA/GCAGAG`	1	--	us2k¹		0	--	--	--	--
rs145039944^1,2		--	31078010(+)	`CTGGGC/GTGGCC`	1	--	us2k¹		0	--	--	--	--
rs147573543^1,2		--	31078088(+)	`CGAGAC/TACAGA`	1	--	us2k¹		0	--	--	--	--
rs1549106^1,2	C,F,H,	--	31078173(-)	`AAGAAG/AGAGAT`	1	--	us2k¹		15		NS EA NA	1936
rs76326994^1,2	F,	--	31078233(+)	`CAGCCC/GGGGCC`	1	--	us2k¹		1		EA	120
rs76758611^1,2		--	31078268(+)	`TCTCCC/TGAGTC`	1	--	us2k¹		0	--	--	--	--
rs191088277^1,2		--	31078323(+)	`ATAGTC/TTCCGT`	1	--	us2k¹		0	--	--	--	--
rs150122228^1,2		--	31078373(+)	`CTTCAA/GCCCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TSPAN11 (31079362 - 31149537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for TSPAN11
9 CNVs: 34528 66180 8716 3884 5307 5290 5292 5291 5281

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TSPAN11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPAN11)

Utopia: connect your pdf to the dynamic
world of online information

The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)¹ Clark H.F.... Gray A.M. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 441631	HGNC: 30795	AceView: LOC441631	Ensembl:ENSG00000110900	euGenes: HUgn441631
ECgene: TSPAN11	H-InvDB: TSPAN11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TSPAN11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TSPAN11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TSPAN11 gene:
Search GeneIP for patents involving TSPAN11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TSPAN11 gene at Home site.

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TSPAN11 Gene

tetraspanin 11

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Export list of displayed genes

TSPAN11 Gene

tetraspanin 11

Aliasesfor TSPAN11 gene

Summariesfor TSPAN11 gene

Genomic Viewsfor TSPAN11 gene

Proteinsfor TSPAN11 gene

Protein Domains /Familiesfor TSPAN11 gene

Functionfor TSPAN11 gene

Pathways & Interactionsfor TSPAN11 gene

Drugs & Compoundsfor TSPAN11 gene

Transcriptsfor TSPAN11 gene

Expression for TSPAN11 gene

Orthologsfor TSPAN11 gene

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Genomic Variantsfor TSPAN11 gene

Disorders / Diseasesfor TSPAN11 gene

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External Searches for TSPAN11 gene

Genome Databases showing TSPAN11 gene

Other Databases showing TSPAN11 gene

Specialized Databases showing TSPAN11 gene

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for TSPAN11 gene

Summaries
for TSPAN11 gene

Genomic Views
for TSPAN11 gene

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for TSPAN11 gene

Protein Domains /
Families
for TSPAN11 gene

Function
for TSPAN11 gene

Pathways & Interactions
for TSPAN11 gene

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for TSPAN11 gene

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for TSPAN11 gene

Expression
for TSPAN11 gene

Orthologs
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