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Aliases for TSPAN11 Gene

Aliases for TSPAN11 Gene

  • Tetraspanin 11 2 3 5
  • Tspan-11 3 4
  • Tetraspanin-11 3
  • VSSW1971 3

External Ids for TSPAN11 Gene

Previous GeneCards Identifiers for TSPAN11 Gene

  • GC12P030985
  • GC12P030844
  • GC12P031079

Summaries for TSPAN11 Gene

GeneCards Summary for TSPAN11 Gene

TSPAN11 (Tetraspanin 11) is a Protein Coding gene. An important paralog of this gene is CD151.

Additional gene information for TSPAN11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN11 Gene

Genomics for TSPAN11 Gene

GeneHancer (GH) Regulatory Elements for TSPAN11 Gene

Promoters and enhancers for TSPAN11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I030926 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.1 114 1 MXI1 ZNF449 SIN3A ZNF335 ZFHX2 GLIS2 ZBTB48 POLR2A KLF9 PRDM4 TSPAN11 PIR51550
GH12I030930 Promoter 0.7 EPDnew 550.8 +4.0 3981 0.1 POLR2A NR2F2 TSPAN11 PIR51550
GH12I030927 Enhancer 0.2 FANTOM5 553.1 +1.6 1565 0 TSPAN11 PIR51550
GH12I030908 Enhancer 0.6 ENCODE 20 -17.1 -17112 2.1 ELF3 FOXA2 NFIA SP5 FOXA3 JUND POLR2A GLIS1 FOXP2 PRDM10 TSPAN11 LINC00941 PPIAP44
GH12I031810 Enhancer 0.8 ENCODE 4.7 +884.7 884736 1.4 HDGF PKNOX1 SMAD1 BMI1 YBX1 BATF KLF5 IRF4 ZNF143 ETV6 GC12P031812 ENSG00000252204 TSPAN11 ENSG00000256372
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSPAN11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN11 gene promoter:

Genomic Locations for TSPAN11 Gene

Genomic Locations for TSPAN11 Gene
chr12:30,926,428-31,016,490
(GRCh38/hg38)
Size:
90,063 bases
Orientation:
Plus strand
chr12:31,079,362-31,149,537
(GRCh37/hg19)

Genomic View for TSPAN11 Gene

Genes around TSPAN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN11 Gene

Proteins for TSPAN11 Gene

  • Protein details for TSPAN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L157-TSN11_HUMAN
    Recommended name:
    Tetraspanin-11
    Protein Accession:
    A1L157
    Secondary Accessions:
    • A1L158
    • B2RUX6

    Protein attributes for TSPAN11 Gene

    Size:
    253 amino acids
    Molecular mass:
    28245 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN11 Gene

Post-translational modifications for TSPAN11 Gene

Other Protein References for TSPAN11 Gene

No data available for DME Specific Peptides for TSPAN11 Gene

Domains & Families for TSPAN11 Gene

Gene Families for TSPAN11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN11 Gene

Suggested Antigen Peptide Sequences for TSPAN11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L157

UniProtKB/Swiss-Prot:

TSN11_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN11: view

Function for TSPAN11 Gene

Phenotypes From GWAS Catalog for TSPAN11 Gene

Phenotypes for TSPAN11 Gene

genes like me logo Genes that share phenotypes with TSPAN11: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN11 Gene

Localization for TSPAN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN11 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSPAN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN11: view

Pathways & Interactions for TSPAN11 Gene

SuperPathways for TSPAN11 Gene

No Data Available

Interacting Proteins for TSPAN11 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261177%0d%0a9606.ENSP00000387564%0d%0a9606.ENSP00000222573%0d%0a9606.ENSP00000267082%0d%0a
Selected Interacting proteins: ENSP00000261177 for TSPAN11 Gene via STRING

Gene Ontology (GO) - Biological Process for TSPAN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN11: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN11 Gene

Drugs & Compounds for TSPAN11 Gene

No Compound Related Data Available

Transcripts for TSPAN11 Gene

mRNA/cDNA for TSPAN11 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPAN11 Gene

Tetraspanin 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for TSPAN11 Gene

GeneLoc Exon Structure for
TSPAN11
ECgene alternative splicing isoforms for
TSPAN11

Expression for TSPAN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN11 Gene

This gene is overexpressed in Colon - Sigmoid (x4.7).

Protein differential expression in normal tissues from HIPED for TSPAN11 Gene

This gene is overexpressed in Colon (42.0), Rectum (13.8), and Prostate (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN11 Gene



Protein tissue co-expression partners for TSPAN11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN11 Gene:

TSPAN11

SOURCE GeneReport for Unigene cluster for TSPAN11 Gene:

Hs.505141

Evidence on tissue expression from TISSUES for TSPAN11 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TSPAN11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN11 Gene

Orthologs for TSPAN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN11 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia TSPAN11 33 34
  • 88.67 (n)
cow
(Bos Taurus)
Mammalia TSPAN11 33 34
  • 86.43 (n)
rat
(Rattus norvegicus)
Mammalia Tspan11 33
  • 84.85 (n)
mouse
(Mus musculus)
Mammalia Tspan11 33 16 34
  • 84.19 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPAN11 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN11 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732684 33
  • 62.95 (n)
zebrafish
(Danio rerio)
Actinopterygii tspan11 33 34
  • 70.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp74F 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8828 34
  • 42 (a)
OneToMany
Species where no ortholog for TSPAN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN11 Gene

ENSEMBL:
Gene Tree for TSPAN11 (if available)
TreeFam:
Gene Tree for TSPAN11 (if available)

Paralogs for TSPAN11 Gene

(15) SIMAP similar genes for TSPAN11 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TSPAN11 Gene

genes like me logo Genes that share paralogs with TSPAN11: view

Variants for TSPAN11 Gene

Sequence variations from dbSNP and Humsavar for TSPAN11 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000025433 -- 30,988,328(+) C/T intron_variant
rs1000042764 -- 30,946,604(+) C/T intron_variant
rs1000156437 -- 30,946,369(+) G/T intron_variant
rs1000187010 -- 30,953,431(+) C/T intron_variant
rs1000208089 -- 30,986,593(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN11 Gene

Variant ID Type Subtype PubMed ID
dgv1413n100 CNV gain 25217958
dgv1414n100 CNV gain 25217958
dgv1415n100 CNV gain 25217958
dgv1416n100 CNV gain 25217958
dgv7e196 CNV duplication 17116639
esv2422447 CNV duplication 17116639
esv25193 CNV loss 19812545
esv2676723 CNV deletion 23128226
esv2745711 CNV deletion 23290073
esv2751043 CNV gain 17911159
esv2759890 CNV gain+loss 17122850
esv3303087 CNV tandem duplication 20981092
esv3306795 CNV mobile element insertion 20981092
esv3309360 CNV mobile element insertion 20981092
esv3342394 CNV insertion 20981092
esv3360756 CNV insertion 20981092
esv3581161 CNV gain 25503493
esv3629028 CNV gain 21293372
esv3629029 CNV loss 21293372
nsv1035182 CNV gain 25217958
nsv1038745 CNV gain 25217958
nsv1043720 CNV gain 25217958
nsv1118231 CNV deletion 24896259
nsv1147184 CNV insertion 26484159
nsv428276 CNV gain 18775914
nsv469193 CNV loss 19166990
nsv520694 CNV loss 19592680
nsv522849 CNV gain 19592680
nsv524047 CNV loss 19592680
nsv525788 CNV loss 19592680
nsv558030 CNV gain 21841781
nsv558031 CNV loss 21841781
nsv658 CNV deletion 18451855
nsv832362 CNV loss 17160897

Variation tolerance for TSPAN11 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN11 Gene

Human Gene Mutation Database (HGMD)
TSPAN11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN11 Gene

Disorders for TSPAN11 Gene

Additional Disease Information for TSPAN11

No disorders were found for TSPAN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN11 Gene

Publications for TSPAN11 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 58

Products for TSPAN11 Gene

Sources for TSPAN11 Gene

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