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Aliases for TSPAN11 Gene

Aliases for TSPAN11 Gene

  • Tetraspanin 11 2 3 5
  • Tspan-11 3 4
  • VSSW1971 3

External Ids for TSPAN11 Gene

Previous GeneCards Identifiers for TSPAN11 Gene

  • GC12P030985
  • GC12P030844
  • GC12P031079

Summaries for TSPAN11 Gene

GeneCards Summary for TSPAN11 Gene

TSPAN11 (Tetraspanin 11) is a Protein Coding gene. An important paralog of this gene is ENSG00000250349.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN11 Gene

Genomics for TSPAN11 Gene

Regulatory Elements for TSPAN11 Gene

Promoters for TSPAN11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN11 Gene

Chromosome:
12
Start:
30,926,428 bp from pter
End:
31,016,490 bp from pter
Size:
90,063 bases
Orientation:
Plus strand

Genomic View for TSPAN11 Gene

Genes around TSPAN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN11 Gene

Proteins for TSPAN11 Gene

  • Protein details for TSPAN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L157-TSN11_HUMAN
    Recommended name:
    Tetraspanin-11
    Protein Accession:
    A1L157
    Secondary Accessions:
    • A1L158
    • B2RUX6

    Protein attributes for TSPAN11 Gene

    Size:
    253 amino acids
    Molecular mass:
    28245 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN11 Gene

Proteomics data for TSPAN11 Gene at MOPED

Post-translational modifications for TSPAN11 Gene

Other Protein References for TSPAN11 Gene

No data available for DME Specific Peptides for TSPAN11 Gene

Domains & Families for TSPAN11 Gene

Gene Families for TSPAN11 Gene

Protein Domains for TSPAN11 Gene

Suggested Antigen Peptide Sequences for TSPAN11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L157

UniProtKB/Swiss-Prot:

TSN11_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN11: view

Function for TSPAN11 Gene

Phenotypes for TSPAN11 Gene

GenomeRNAi human phenotypes for TSPAN11:
genes like me logo Genes that share phenotypes with TSPAN11: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN11 Gene

Localization for TSPAN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN11 Gene COMPARTMENTS Subcellular localization image for TSPAN11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TSPAN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN11: view

Pathways & Interactions for TSPAN11 Gene

SuperPathways for TSPAN11 Gene

No Data Available

Interacting Proteins for TSPAN11 Gene

Selected Interacting proteins: A1L157-TSN11_HUMAN for TSPAN11 Gene via I2D

Symbol External ID(s) Details
DYNC2LI1

Gene Ontology (GO) - Biological Process for TSPAN11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TSPAN11 Gene

Drugs & Compounds for TSPAN11 Gene

No Compound Related Data Available

Transcripts for TSPAN11 Gene

Unigene Clusters for TSPAN11 Gene

Tetraspanin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for TSPAN11 Gene

GeneLoc Exon Structure for
TSPAN11
ECgene alternative splicing isoforms for
TSPAN11

Expression for TSPAN11 Gene

mRNA expression in normal human tissues for TSPAN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN11 Gene

This gene is overexpressed in Colon - Sigmoid (x4.7).

Protein differential expression in normal tissues from HIPED for TSPAN11 Gene

This gene is overexpressed in Colon (42.0), Rectum (13.8), and Prostate (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN11 Gene



SOURCE GeneReport for Unigene cluster for TSPAN11 Gene Hs.505141

genes like me logo Genes that share expression patterns with TSPAN11: view

Protein tissue co-expression partners for TSPAN11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN11 Gene

Orthologs for TSPAN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSPAN11 35
  • 86.43 (n)
  • 87.35 (a)
TSPAN11 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN11 35
  • 88.67 (n)
  • 89.33 (a)
TSPAN11 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan11 35
  • 84.19 (n)
  • 87.35 (a)
Tspan11 16
Tspan11 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSPAN11 35
  • 99.12 (n)
  • 98.41 (a)
TSPAN11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan11 35
  • 84.85 (n)
  • 86.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TSPAN11 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN11 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732684 35
  • 62.95 (n)
  • 59.92 (a)
zebrafish
(Danio rerio)
Actinopterygii tspan11 35
  • 70.63 (n)
  • 71.43 (a)
tspan11 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp74F 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8828 36
  • 42 (a)
OneToMany
Species with no ortholog for TSPAN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN11 Gene

ENSEMBL:
Gene Tree for TSPAN11 (if available)
TreeFam:
Gene Tree for TSPAN11 (if available)

Paralogs for TSPAN11 Gene

(15) SIMAP similar genes for TSPAN11 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TSPAN11 Gene

genes like me logo Genes that share paralogs with TSPAN11: view

Variants for TSPAN11 Gene

Sequence variations from dbSNP and Humsavar for TSPAN11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2075333 - 30,982,644(+) GGTGG(C/T)GCGCT nc-transcript-variant, reference, missense
rs1950 -- 30,975,671(-) TTACT(A/G)TTGAA intron-variant
rs3426 -- 30,966,117(+) ATTCA(A/C)TGCAC intron-variant
rs3427 -- 30,966,137(+) ggagg(C/T)ggggg intron-variant
rs28281 -- 30,989,680(-) CCATG(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN11 Gene

Variant ID Type Subtype PubMed ID
esv2422447 CNV Duplication 17116639
nsv832362 CNV Loss 17160897
dgv7e196 CNV Duplication 17116639
nsv658 CNV Loss 18451855
esv260061 OTHER Complex 20981092
nsv522849 CNV Gain 19592680
esv2676723 CNV Deletion 23128226
esv25193 CNV Loss 19812545
nsv520694 CNV Loss 19592680
nsv524047 CNV Loss 19592680
esv2745711 CNV Deletion 23290073
esv273633 CNV Insertion 20981092
esv271071 CNV Insertion 20981092
dgv489e1 CNV Complex 17122850
nsv428276 CNV Gain 18775914
nsv525788 CNV Loss 19592680
nsv469193 CNV Loss 19166990
esv2751043 CNV Gain 17911159

Variation tolerance for TSPAN11 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN11 Gene

HapMap Linkage Disequilibrium report
TSPAN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN11 Gene

Disorders for TSPAN11 Gene

Relevant External Links for TSPAN11

Genetic Association Database (GAD)
TSPAN11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN11

No disorders were found for TSPAN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN11 Gene

Publications for TSPAN11 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TSPAN11 Gene

Sources for TSPAN11 Gene

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