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Aliases for TSPAN10 Gene

Aliases for TSPAN10 Gene

  • Tetraspanin 10 2 3 5
  • Oculospanin 2 3 4
  • Tspan-10 3 4
  • OCSP 3 4
  • Tetraspanin-10 3

External Ids for TSPAN10 Gene

Previous GeneCards Identifiers for TSPAN10 Gene

  • GC17P077220
  • GC17P079609
  • GC17P075055

Summaries for TSPAN10 Gene

GeneCards Summary for TSPAN10 Gene

TSPAN10 (Tetraspanin 10) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN5.

UniProtKB/Swiss-Prot for TSPAN10 Gene

  • Regulates maturation of the transmembrane metalloprotease ADAM10.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN10 Gene

Genomics for TSPAN10 Gene

Regulatory Elements for TSPAN10 Gene

Enhancers for TSPAN10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F081452 1.6 FANTOM5 Ensembl ENCODE 32.1 -179.1 -179069 10.4 ZNF493 ZFP64 GLIS2 ELK1 ZNF548 FOS ZNF263 ZNF202 SP3 YY2 ENSG00000262049 OGFOD3 CEP131 RFNG HGS ENSG00000265678 TSPAN10 ENSG00000262877 TEPSIN ENSG00000229848
GH17F081596 1.1 Ensembl ENCODE 34 -37.7 -37712 5.4 HDGF CTCF SIN3A RAD21 ZNF316 POLR2A EED ZNF143 SMC3 ETV6 TSPAN10 NPLOC4 ARL16 FAAP100 PDE6G OXLD1 CCDC137 TMEM105 OGFOD3 GC17M081598
GH17F081558 1.1 Ensembl ENCODE 33.4 -72.8 -72809 11.1 PKNOX1 SIN3A FEZF1 RAD21 ZNF366 FOS EGR2 ZNF263 SMARCC1 CEBPB NPLOC4 TSPAN10 ARL16 OXLD1 ENSG00000229848 FSCN2 ENSG00000262877 PDE6G CCDC137 GCGR
GH17F081897 1.2 Ensembl ENCODE 20.3 +262.0 261977 3.4 ELF3 ZFP64 INSM2 ARID4B SIN3A ZNF366 FOS EGR2 ZNF202 ZNF362 ENSG00000262049 OGFOD3 RFNG CEP131 ENSG00000263321 ENSG00000265678 HGS LOC105371942 TSPAN10 ENSG00000229848
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN10 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the TSPAN10 gene promoter:

Genomic Location for TSPAN10 Gene

81,637,171 bp from pter
81,648,755 bp from pter
11,585 bases
Plus strand

Genomic View for TSPAN10 Gene

Genes around TSPAN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN10 Gene

Proteins for TSPAN10 Gene

  • Protein details for TSPAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N548

    Protein attributes for TSPAN10 Gene

    355 amino acids
    Molecular mass:
    36498 Da
    Quaternary structure:
    • Interacts with ADAM10.

neXtProt entry for TSPAN10 Gene

Post-translational modifications for TSPAN10 Gene

  • Glycosylation at Asn 228
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN10 Gene

No data available for DME Specific Peptides for TSPAN10 Gene

Domains & Families for TSPAN10 Gene

Gene Families for TSPAN10 Gene

Suggested Antigen Peptide Sequences for TSPAN10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN10: view

Function for TSPAN10 Gene

Molecular function for TSPAN10 Gene

UniProtKB/Swiss-Prot Function:
Regulates maturation of the transmembrane metalloprotease ADAM10.

Gene Ontology (GO) - Molecular Function for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN10: view

Phenotypes for TSPAN10 Gene

genes like me logo Genes that share phenotypes with TSPAN10: view

Animal Model Products

miRNA for TSPAN10 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN10 Gene

Localization for TSPAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN10 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Subcellular locations from COMPARTMENTS for TSPAN10 Gene

Pathways & Interactions for TSPAN10 Gene

SuperPathways for TSPAN10 Gene

No Data Available

Interacting Proteins for TSPAN10 Gene

Gene Ontology (GO) - Biological Process for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0045747 positive regulation of Notch signaling pathway IBA --
GO:0072594 establishment of protein localization to organelle IDA 23091066
GO:0090002 establishment of protein localization to plasma membrane IBA --
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN10 Gene

Transcripts for TSPAN10 Gene

Unigene Clusters for TSPAN10 Gene

Tetraspanin 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN10 Gene

No ASD Table

Relevant External Links for TSPAN10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN10 Gene

Protein differential expression in normal tissues from HIPED for TSPAN10 Gene

This gene is overexpressed in Breast (16.2), Spleen (9.5), Retina (9.1), Stomach (9.1), Uterus (6.8), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN10 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN10 Gene:


mRNA Expression by UniProt/SwissProt for TSPAN10 Gene:

Tissue specificity: Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).
genes like me logo Genes that share expression patterns with TSPAN10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for TSPAN10 Gene

Orthologs for TSPAN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN10 34 35
  • 99.15 (n)
(Bos Taurus)
Mammalia TSPAN10 34 35
  • 81.28 (n)
(Canis familiaris)
Mammalia TSPAN10 34 35
  • 77.44 (n)
(Rattus norvegicus)
Mammalia Tspan10 34
  • 73.18 (n)
(Mus musculus)
Mammalia Tspan10 34 16 35
  • 71.52 (n)
(Monodelphis domestica)
Mammalia TSPAN10 35
  • 52 (a)
(Gallus gallus)
Aves TSPAN10 34 35
  • 64.41 (n)
(Anolis carolinensis)
Reptilia TSPAN10 35
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731851 34
  • 53.62 (n)
(Danio rerio)
Actinopterygii LOC799194 34
  • 51.42 (n)
CR855387.1 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea tsp-14 35
  • 18 (a)
Species where no ortholog for TSPAN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN10 Gene

Gene Tree for TSPAN10 (if available)
Gene Tree for TSPAN10 (if available)

Paralogs for TSPAN10 Gene

Paralogs for TSPAN10 Gene

(7) SIMAP similar genes for TSPAN10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSPAN10: view

Variants for TSPAN10 Gene

Sequence variations from dbSNP and Humsavar for TSPAN10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10536197 -- 81,647,907(+) TAACT(-/AACT)GCAGC nc-transcript-variant, reference, frameshift-variant, cds-indel
rs10627051 -- 81,635,367(+) AAAAA(-/AAA)GGAGT intron-variant, upstream-variant-2KB
rs10652259 -- 81,635,926(+) GGTTT(-/TC)TCTGA intron-variant, upstream-variant-2KB
rs10699191 -- 81,641,889(+) AAAAC(-/AAAAACAAGG/AAGG)AAGGA intron-variant, upstream-variant-2KB
rs111322465 -- 81,646,251(+) GCCAG(G/T)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN10 Gene

Variant ID Type Subtype PubMed ID
nsv952390 CNV deletion 24416366
nsv828128 CNV loss 20364138
nsv470620 CNV loss 18288195
nsv428351 CNV gain 18775914
nsv1148351 CNV deletion 26484159
nsv1071813 CNV deletion 25765185
esv3554887 CNV deletion 23714750
esv2716456 CNV deletion 23290073
esv2716455 CNV deletion 23290073
esv2674289 CNV deletion 23128226
esv26223 CNV gain+loss 19812545
esv1981187 CNV deletion 18987734
esv1711846 CNV deletion 17803354
dgv1523n106 CNV deletion 24896259

Relevant External Links for TSPAN10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TSPAN10 Gene

Disorders for TSPAN10 Gene

Relevant External Links for TSPAN10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN10 Gene

Publications for TSPAN10 Gene

  1. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E. … Rubinstein E. (J. Cell Biol. 2012) 3 64
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TSPAN10 Gene

Sources for TSPAN10 Gene

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