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Aliases for TSPAN10 Gene

Aliases for TSPAN10 Gene

  • Tetraspanin 10 2 3
  • Oculospanin 2 3 4
  • Tspan-10 3 4
  • OCSP 3 4
  • Tetraspanin-10 3

External Ids for TSPAN10 Gene

Previous GeneCards Identifiers for TSPAN10 Gene

  • GC17P077220
  • GC17P079609
  • GC17P075055

Summaries for TSPAN10 Gene

GeneCards Summary for TSPAN10 Gene

TSPAN10 (Tetraspanin 10) is a Protein Coding gene. An important paralog of this gene is TSPAN7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN10 Gene

Genomics for TSPAN10 Gene

Regulatory Elements for TSPAN10 Gene

Transcription factor binding sites by QIAGEN in the TSPAN10 gene promoter:

Genomic Location for TSPAN10 Gene

81,637,171 bp from pter
81,648,749 bp from pter
11,579 bases
Plus strand

Genomic View for TSPAN10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN10 Gene

Proteins for TSPAN10 Gene

  • Protein details for TSPAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N548

    Protein attributes for TSPAN10 Gene

    355 amino acids
    Molecular mass:
    36498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN10 Gene

Proteomics data for TSPAN10 Gene at MOPED

Post-translational modifications for TSPAN10 Gene

  • Glycosylation at Asn228
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN10 Gene

Antibody Products

No data available for DME Specific Peptides for TSPAN10 Gene

Domains for TSPAN10 Gene

Gene Families for TSPAN10 Gene

Suggested Antigen Peptide Sequences for TSPAN10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN10: view

Function for TSPAN10 Gene

Gene Ontology (GO) - Molecular Function for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN10: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN10

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSPAN10 Gene

Localization for TSPAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN10 Gene COMPARTMENTS Subcellular localization image for TSPAN10 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN10: view

Pathways for TSPAN10 Gene

SuperPathways for TSPAN10 Gene

No Data Available

Interacting Proteins for TSPAN10 Gene

Selected Interacting proteins: Q9H1Z9-TSN10_HUMAN for TSPAN10 Gene via MINT

Gene Ontology (GO) - Biological Process for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051604 protein maturation --
GO:0072594 establishment of protein localization to organelle IDA 23091066
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Pathways by source for TSPAN10 Gene

Transcripts for TSPAN10 Gene

Unigene Clusters for TSPAN10 Gene

Tetraspanin 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN10 Gene

No ASD Table

Relevant External Links for TSPAN10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN10 Gene

mRNA expression in normal human tissues for TSPAN10 Gene

Protein differential expression in normal tissues for TSPAN10 Gene

This gene is overexpressed in Breast (16.2), Spleen (9.5), Retina (9.1), Stomach (9.1), Uterus (6.8), and Ovary (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TSPAN10 Gene

SOURCE GeneReport for Unigene cluster for TSPAN10 Gene Hs.740811

mRNA Expression by UniProt/SwissProt for TSPAN10 Gene

Tissue specificity: Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).
genes like me logo Genes that share expressions with TSPAN10: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for TSPAN10 Gene

Orthologs for TSPAN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN10 35
  • 81.28 (n)
  • 77.05 (a)
TSPAN10 36
  • 69 (a)
(Canis familiaris)
Mammalia TSPAN10 35
  • 77.44 (n)
  • 73.68 (a)
TSPAN10 36
  • 74 (a)
(Mus musculus)
Mammalia Tspan10 35
  • 71.52 (n)
  • 64.9 (a)
Tspan10 16
Tspan10 36
  • 65 (a)
(Pan troglodytes)
Mammalia TSPAN10 35
  • 99.15 (n)
  • 98.87 (a)
TSPAN10 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tspan10 35
  • 73.18 (n)
  • 66.23 (a)
(Monodelphis domestica)
Mammalia TSPAN10 36
  • 52 (a)
(Gallus gallus)
Aves TSPAN10 35
  • 64.41 (n)
  • 52.54 (a)
TSPAN10 36
  • 44 (a)
(Anolis carolinensis)
Reptilia TSPAN10 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731851 35
  • 53.62 (n)
  • 44.35 (a)
(Danio rerio)
Actinopterygii LOC799194 35
  • 51.42 (n)
  • 39.59 (a)
CR855387.1 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea tsp-14 36
  • 18 (a)
Species with no ortholog for TSPAN10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN10 Gene

Gene Tree for TSPAN10 (if available)
Gene Tree for TSPAN10 (if available)

Paralogs for TSPAN10 Gene

(7) SIMAP similar genes for TSPAN10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSPAN10: view

Variants for TSPAN10 Gene

Sequence variations from dbSNP and Humsavar for TSPAN10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6420484 -- 81,645,371(+) TGGCT(A/G)CCTGG reference, missense, nc-transcript-variant
rs6565616 -- 81,645,135(+) GGCAC(C/T)CCCAA reference, synonymous-codon, nc-transcript-variant
rs6565617 -- 81,645,307(+) TGCCC(A/G/T)CAGAC missense, reference, nc-transcript-variant
rs7210026 -- 81,645,356(+) CGCAG(C/T)GAGCC missense, reference, nc-transcript-variant
rs7210043 -- 81,645,387(+) CTCTG(C/T)GAGAA synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN10 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
nsv909110 CNV Loss 21882294
nsv909111 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
esv1981187 CNV Deletion 18987734
esv2716455 CNV Deletion 23290073
esv2674289 CNV Deletion 23128226
esv1711846 CNV Deletion 17803354
esv2716456 CNV Deletion 23290073

Relevant External Links for TSPAN10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN10 Gene

Disorders for TSPAN10 Gene

(1) University of Copenhagen DISEASES for TSPAN10 Gene

genes like me logo Genes that share disorders with TSPAN10: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for TSPAN10 Gene

Publications for TSPAN10 Gene

  1. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TSPAN10 Gene

Sources for TSPAN10 Gene

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