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Aliases for TSPAN10 Gene

Aliases for TSPAN10 Gene

  • Tetraspanin 10 2 3 5
  • Oculospanin 2 3 4
  • Tspan-10 3 4
  • OCSP 3 4

External Ids for TSPAN10 Gene

Previous GeneCards Identifiers for TSPAN10 Gene

  • GC17P077220
  • GC17P079609
  • GC17P075055

Summaries for TSPAN10 Gene

GeneCards Summary for TSPAN10 Gene

TSPAN10 (Tetraspanin 10) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is ENSG00000250349.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN10 Gene

Genomics for TSPAN10 Gene

Regulatory Elements for TSPAN10 Gene

Enhancers for TSPAN10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN10 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TSPAN10 gene promoter:

Genomic Location for TSPAN10 Gene

Chromosome:
17
Start:
81,637,171 bp from pter
End:
81,648,755 bp from pter
Size:
11,585 bases
Orientation:
Plus strand

Genomic View for TSPAN10 Gene

Genes around TSPAN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN10 Gene

Proteins for TSPAN10 Gene

  • Protein details for TSPAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1Z9-TSN10_HUMAN
    Recommended name:
    Tetraspanin-10
    Protein Accession:
    Q9H1Z9
    Secondary Accessions:
    • Q8N548

    Protein attributes for TSPAN10 Gene

    Size:
    355 amino acids
    Molecular mass:
    36498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN10 Gene

Proteomics data for TSPAN10 Gene at MOPED

Post-translational modifications for TSPAN10 Gene

  • Glycosylation at Asn 228
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN10 Gene

No data available for DME Specific Peptides for TSPAN10 Gene

Domains & Families for TSPAN10 Gene

Gene Families for TSPAN10 Gene

Suggested Antigen Peptide Sequences for TSPAN10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1Z9

UniProtKB/Swiss-Prot:

TSN10_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN10: view

Function for TSPAN10 Gene

Phenotypes for TSPAN10 Gene

GenomeRNAi human phenotypes for TSPAN10:
genes like me logo Genes that share phenotypes with TSPAN10: view

Animal Model Products

miRNA for TSPAN10 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN10 Gene

Localization for TSPAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN10 Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TSPAN10 Gene

Pathways & Interactions for TSPAN10 Gene

SuperPathways for TSPAN10 Gene

No Data Available

Interacting Proteins for TSPAN10 Gene

Selected Interacting proteins: Q9H1Z9-TSN10_HUMAN for TSPAN10 Gene via MINT

Gene Ontology (GO) - Biological Process for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0045747 positive regulation of Notch signaling pathway IBA --
GO:0090002 establishment of protein localization to plasma membrane IBA --
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN10 Gene

Drugs & Compounds for TSPAN10 Gene

No Compound Related Data Available

Transcripts for TSPAN10 Gene

Unigene Clusters for TSPAN10 Gene

Tetraspanin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN10 Gene

No ASD Table

Relevant External Links for TSPAN10 Gene

GeneLoc Exon Structure for
TSPAN10
ECgene alternative splicing isoforms for
TSPAN10

Expression for TSPAN10 Gene

mRNA expression in normal human tissues for TSPAN10 Gene

Protein differential expression in normal tissues from HIPED for TSPAN10 Gene

This gene is overexpressed in Breast (16.2), Spleen (9.5), Retina (9.1), Stomach (9.1), Uterus (6.8), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TSPAN10 Gene



SOURCE GeneReport for Unigene cluster for TSPAN10 Gene Hs.740811

mRNA Expression by UniProt/SwissProt for TSPAN10 Gene

Q9H1Z9-TSN10_HUMAN
Tissue specificity: Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).
genes like me logo Genes that share expression patterns with TSPAN10: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for TSPAN10 Gene

Orthologs for TSPAN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSPAN10 35
  • 81.28 (n)
  • 77.05 (a)
TSPAN10 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN10 35
  • 77.44 (n)
  • 73.68 (a)
TSPAN10 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan10 35
  • 71.52 (n)
  • 64.9 (a)
Tspan10 16
Tspan10 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSPAN10 35
  • 99.15 (n)
  • 98.87 (a)
TSPAN10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan10 35
  • 73.18 (n)
  • 66.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TSPAN10 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN10 35
  • 64.41 (n)
  • 52.54 (a)
TSPAN10 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN10 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731851 35
  • 53.62 (n)
  • 44.35 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799194 35
  • 51.42 (n)
  • 39.59 (a)
CR855387.1 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tsp-14 36
  • 18 (a)
OneToMany
Species with no ortholog for TSPAN10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN10 Gene

ENSEMBL:
Gene Tree for TSPAN10 (if available)
TreeFam:
Gene Tree for TSPAN10 (if available)

Paralogs for TSPAN10 Gene

(7) SIMAP similar genes for TSPAN10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSPAN10: view

Variants for TSPAN10 Gene

Sequence variations from dbSNP and Humsavar for TSPAN10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34896443 - 81,645,515(+) CCTGC(A/G)TGTGG nc-transcript-variant, reference, missense
rs34379910 - 81,645,607(+) CCTCC(C/T)ACCAG nc-transcript-variant, reference, missense
rs6420484 -- 81,645,371(+) TGGCT(A/G/T)CCTGG nc-transcript-variant, reference, missense
rs7210026 -- 81,645,356(+) CGCAG(C/T)GAGCC nc-transcript-variant, reference, missense
rs7210043 -- 81,645,387(+) CTCTG(C/T)GAGAA nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TSPAN10 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
nsv909110 CNV Loss 21882294
nsv909111 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
esv1981187 CNV Deletion 18987734
esv2716455 CNV Deletion 23290073
esv2674289 CNV Deletion 23128226
esv1711846 CNV Deletion 17803354
esv2716456 CNV Deletion 23290073

Relevant External Links for TSPAN10 Gene

HapMap Linkage Disequilibrium report
TSPAN10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TSPAN10 Gene

Disorders for TSPAN10 Gene

Relevant External Links for TSPAN10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN10

No disorders were found for TSPAN10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN10 Gene

Publications for TSPAN10 Gene

  1. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E. … Rubinstein E. (J. Cell Biol. 2012) 3
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TSPAN10 Gene

Sources for TSPAN10 Gene

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