TSPAN10 Gene
protein-coding GIFtS : 45
GCID: GC17 P079609
tetraspanin 10
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Aliasesfor TSPAN10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tetraspanin 10 1 2 Tspan-103 OCSP1 2 3 Oculospanin3 Oculospanin3 Tspan-103 Tetraspanin-101
Export aliases for TSPAN10 gene to outside databases Previous GC identifers: GC17P077220 GC17P075055
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Summariesfor TSPAN10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TSPAN10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TSPAN10 gene promoter: STAT5A Other transcription factors Search SABiosciences Chromatin IP Primers for TSPAN10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3 TSPAN10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P079609: view genomic region
(about GC identifiers )
Start:
79,604,197 bp from pter
End:
79,615,779 bp from pter
Size:
11,583 bases
Orientation:
plus strand
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Proteinsfor TSPAN10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TSN10_HUMAN, Q9H1Z9 (See
protein sequence )Recommended Name: Tetraspanin-10 Size : 355 amino acids; 36498 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : Q8N548Explore the universe of human proteins at neXtProt for TSPAN10: NX_Q9H1Z9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H1Z9 TSPAN10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_114151.3 ENSEMBL proteins: ENSP00000458850 ENSP00000331620 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
TSPAN10 for ontologies About GeneDecksing TSPAN10 Antibody Products: Assay Products for TSPAN10:
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Protein
Domains / Familiesfor TSPAN10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TSPAN10 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H1Z9 ProtoNet protein and cluster: Q9H1Z9
1 Blocks protein family : IPB000301 Transmembrane four family signature UniProtKB/Swiss-Prot: TSN10_HUMAN, Q9H1Z9 Similarity : Belongs to the tetraspanin (TM4SF) family
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Functionfor TSPAN10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN10 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPAN10 (NM_031945 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN10
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Pathways & Interactionsfor TSPAN10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN10 5/50 Interacting proteins for TSPAN10 (Q9H1Z9 2 ) via UniProtKB, MINT, STRING, and/or I2D (see all 50 )About this table
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Drugs & Compoundsfor TSPAN10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TSPAN10 Search CenterWatch for drugs/clinical trials and news about TSPAN10 / TSN10
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Transcriptsfor TSPAN10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TSPAN10 gene: NM_031945.3 Unigene Cluster for TSPAN10:
Tetraspanin 10 Hs.740811 [show with all ESTs ] Unigene Representative Sequence: BC021923 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000571914 (uc002kav.1 ) ENST00000574882 (uc021ufc.1 ) ENST00000571707 (uc002kaw.2 )ENST00000540189 (uc010did.2 ) ENST00000572675 ENST00000328585 (uc010die.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN10 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPAN10 (NM_031945 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPAN10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN10
Additional cDNA sequence: AB593081.1 AB593082.1 AF325213.1 AK096926.1 BC021923.1 BC032802.1
3 DOTS entries : DT.100026153 DT.99970114
DT.97801659 24/36 AceView cDNA sequences (see all 36 ):
BC021923 CA392181 CA396135 BG281014 BG760374 BC032802 BE389030 AI817362 NM_031945 BM666000 BU171498 AK096926 BF724753 BG768002 BM710905 BM707616 BU736759 BE207568 BM724020 CD673102 BF724752 BI488460 BU838118 BF475546 GeneLoc Exon Structure
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Expression for TSPAN10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TSPAN10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image TSPAN10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TSPAN10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSPAN10 SOURCE GeneReport for Unigene cluster: Hs.740811 UniProtKB/Swiss-Prot: TSN10_HUMAN, Q9H1Z9 Tissue specificity : Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens(protein level) SABiosciences Custom PCR Arrays for TSPAN10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPAN10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TSPAN10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPAN10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPAN10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN10
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Orthologsfor TSPAN10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TSPAN10 gene from 3/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for TSPAN10 (if available)TreeFam Gene Tree for TSPAN10 (if available)
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Paralogsfor TSPAN10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TSPAN10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TSPAN10 (79604197 - 79615779 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for TSPAN10 3 CNVs : 30036 73071 30034 3 Indels : 40210 45610 25956
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPAN10
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Disorders
/ Diseasesfor TSPAN10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TSPAN10 for disorders About GeneDecksing 3 diseases for TSPAN10 : About MalaCards cerebrovascular accident choroiditis retinitis 1 disease from the University of Copenhagen DISEASES database for TSPAN10 :Cerebrovascular accident Export disorders for TSPAN10 gene to outside databases
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Publicationsfor TSPAN10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TSPAN10 gene integrated from 9 sources : (articles sorted by number of sources associating them with TSPAN10) Utopia : connect your pdf to the dynamic world of online information
Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107410) 1 , 2 , 3 Wistow G.... Peterson K. (2002) Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133) 1 Oshikawa M.... Kato S. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TSPAN10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TSPAN10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TSPAN10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TSPAN10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TSPAN10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TSPAN10 gene: Search GeneIP for patents involving TSPAN10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TSPAN10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TSPAN10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TSPAN10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPAN10 OriGene Protein Over-expression Lysate for TSPAN10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TSPAN10 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPAN10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TSPAN10 OriGene Custom Protein Services for TSPAN10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPAN10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TSPAN10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPAN10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPAN10
Search Tocris compounds for TSPAN10
TSPAN10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN10
ThermoFisher Antibodies for TSPAN10
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPAN10
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Genomic Views for TSPAN10
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