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TSPAN1 Gene

protein-coding   GIFtS: 55
GCID: GC01P046640

Tetraspanin 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetraspanin 11 2     tetraspanin-12
NET12 5     Tspan-13
TM4C2     Tetraspan NET-13
TM4SF2     Tetraspanin TM4-C3
Tetraspan 12     

External Ids:    HGNC: 206571   Entrez Gene: 101032   Ensembl: ENSG000001174727   OMIM: 6131705   UniProtKB: O606353   

Export aliases for TSPAN1 gene to outside databases

Previous GC identifers: GC01P046360 GC01P044755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPAN1 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSPAN1 Gene:
TSPAN1 (tetraspanin 1) is a protein-coding gene. Diseases associated with TSPAN1 include cervical intraepithelial neoplasia, and cervicitis. An important paralog of this gene is TSPAN2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN1 gene promoter:
         Bach1   AML1a   Hand1   HNF-4alpha2   HNF-4alpha1   Roaz   E47   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN1 promoter sequence
   Search Chromatin IP Primers for TSPAN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33

TSPAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046640:  view genomic region     (about GC identifiers)

Start:
46,640,745 bp from pter      End:
46,651,634 bp from pter
Size:
10,890 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSN1_HUMAN, O60635 (See protein sequence)
Recommended Name: Tetraspanin-1  
Size: 241 amino acids; 26301 Da
Secondary accessions: D3DQ14 O60745 Q5VST0

Explore the universe of human proteins at neXtProt for TSPAN1: NX_O60635

Explore proteomics data for TSPAN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn141, Asn154, Asn178, Asn184

  • See TSPAN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005718.2  
    ENSEMBL proteins: 
     ENSP00000361072  

    TSPAN1 Human Recombinant Protein Products:

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    TSPAN1 Assay Products:

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    Cloud-Clone Corp. ELISAs for TSPAN1
    Cloud-Clone Corp. CLIAs for TSPAN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry O60635

    ProtoNet protein and cluster: O60635

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN1_HUMAN, O60635
    Similarity: Belongs to the tetraspanin (TM4SF) family


    TSPAN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TSPAN1:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPAN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSPAN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPAN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPAN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSPAN1:
    hsa-mir-340-5p (MIRT019642), hsa-mir-320a (MIRT044778), hsa-mir-24-3p (MIRT030610), hsa-mir-26b-5p (MIRT029990)

    Block miRNA regulation of human, mouse, rat TSPAN1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TSPAN1:
    hsa-miR-361-3p hsa-miR-450b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSPAN1
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSPAN1

    Clone
    Products:
         
    OriGene clones in human, mouse for TSPAN1 (see all 6)
    OriGene ORF clones in mouse, rat for TSPAN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN1 (NM_005727)
    Sino Biological Human cDNA Clone for TSPAN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TSPAN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TSPAN1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN1_HUMAN, O60635: Lysosome membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    plasma membrane3
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    TSPAN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TSPAN1 (see all 21)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN1
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN1

    1 Interacting protein for TSPAN1 (O606353) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDKP217413I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN1 (TSN1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSPAN1 gene: 
    NM_005727.3  

    Unigene Cluster for TSPAN1:

    Tetraspanin 1
    Hs.38972  [show with all ESTs]
    Unigene Representative Sequence: NM_005727
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498443 ENST00000372003(uc001cpd.3) ENST00000482928 ENST00000469330
    ENST00000475163 ENST00000482143 ENST00000464786 ENST00000472170 ENST00000470318

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSPAN1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TSPAN1:
    hsa-miR-361-3p hsa-miR-450b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSPAN1
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN1
    Clone
    Products:
         
    OriGene clones in human, mouse for TSPAN1 (see all 6)
    OriGene ORF clones in mouse, rat for TSPAN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPAN1 (NM_005727)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSPAN1
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPAN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN1
      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN1
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN1

    Additional mRNA sequence: 

    AF054838.1 AF065388.1 AF133425.1 AK313774.1 BC000695.2 BC007290.1 BC013404.2 

    18 DOTS entries:

    DT.95224341  DT.99988721  DT.453603  DT.99984995  DT.418611  DT.92033472  DT.100817377  DT.121350413 
    DT.75140879  DT.97859497  DT.121350404  DT.40209407  DT.92445712  DT.95262112  DT.100817378  DT.101956585 
    DT.121350501  DT.121350529 

    Selected AceView cDNA sequences (see all 390):

    AA877926 BQ083751 CB161656 AA916457 AW024859 CA442289 BM819946 BM799199 
    BC007290 BP342136 BU683592 BM983333 AA574382 AI673548 BM856468 AA601071 
    AI459564 NM_005727 BI763537 CD244333 BE249898 AU100579 AW970066 AI090945 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
    SP1:                          -     -     -                             -                                                         
    SP2:                          -     -     -     -     -                 -                                                         
    SP3:                          -     -     -                             -     -     -                                             
    SP4:                                      -                             -                                                         
    SP5:                                                                    -                                                         


    ECgene alternative splicing isoforms for TSPAN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACTGTGA
    TSPAN1 Expression
    About this image


    TSPAN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Renal Collecting Duct System
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
    TSPAN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38972
        Custom PCR Arrays for TSPAN1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TSPAN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan11 , 5 tetraspanin 11, 5 80.56(n)1
    74.17(a)1
      4 (53.10 cM)5
    668051  NM_133681.41  NP_598442.11 
     1161618695 
    chicken
    (Gallus gallus)
    Aves TSPAN11 tetraspanin 1 66.38(n)
    61.7(a)
      424607  NM_001277590.1  NP_001264519.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSPAN16
    tetraspanin 1
    58(a)
    1 ↔ 1
    4(111798514-111819644)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247932 Xenopus laevis transcribed sequence with weak similarity more 72.8(n)    BU912851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054611.12   -- 77.17(n)   393380  BC054611.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp66E6
    Tetraspanin 66E
    23(a)
    1 → many
    3L(8905599-8925165)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-116
    tsp-136
    Protein TSP-13 (tsp-13) mRNA, complete cds
    19(a)
    12(a)
    many ↔ many
    many ↔ many
    X(9163164-9166007) WBGene00006637
    V(19154106-19157705) WBGene00006639


    ENSEMBL Gene Tree for TSPAN1 (if available)
    TreeFam Gene Tree for TSPAN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN1 gene
    TSPAN22  CD92  CD372  TSPAN92  CD532  CD822  TSPAN182  CD812  
    TSPAN42  TSPAN82  
    12 SIMAP similar genes for TSPAN1 using alignment to 1 protein entry:     TSN1_HUMAN:
    TSPAN18    TSPAN6    TSPAN8    CD82    TSPAN4    TSPAN16
    TM4SF2    TSPAN3    CD53    TSPAN11    TSPAN9    TSPAN7

    TSPAN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN1 (see all 300)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148929161,2
    F--46638787(+) TGTGAG/AAAGGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1396288581,2
    C--46638934(+) GCAAAC/TGGAGC 1 -- us2k10--------
    rs1861178461,2
    --46638971(+) CTCACA/GATTTA 1 -- us2k10--------
    rs558849401,2
    C,F--46639016(+) TCACTG/AAGCTA 1 -- us2k14Minor allele frequency- A:0.15NA WA 242
    rs1429058111,2
    --46639115(+) TGACTA/GACACA 1 -- us2k10--------
    rs1461365811,2
    --46639427(+) GAGATA/GATGTC 1 -- us2k10--------
    rs1892582011,2
    --46639562(+) CACTCA/TTATAG 1 -- us2k10--------
    rs1159942031,2
    F--46639595(+) AGGGCC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1487939661,2
    C--46639710(+) GTGTCC/TGGGTG 1 -- us2k10--------
    rs1424753601,2
    --46639753(+) CATGCA/GTATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSPAN1 (46640745 - 46651634 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSPAN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822520CNV Loss20364138
    nsv527878CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TSPAN1
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613170    OMIM disorders: --

    7 diseases for TSPAN1:    
    About MalaCards
    cervical intraepithelial neoplasia    cervicitis    hepatitis b    hepatocellular carcinoma
    hepatitis    squamous cell carcinoma    breast cancer


    TSPAN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSPAN1
    Human Genome Epidemiology (HuGE) Navigator: TSPAN1 (1 document)

    Export disorders for TSPAN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TSPAN1)
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    1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PubMed id 9714763)1, 2, 3 Todd S.C.... Levy S. (Biochim. Biophys. Acta 1998)
    2. Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum. (PubMed id 19508227)1, 2 Scholz C.-J.... Deissler H. (Protein Pept. Lett. 2009)
    3. Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. (PubMed id 19139842)1, 4 Lin X....Mooser V. (Diabetologia 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Sequence and expression of seven new tetraspans. (PubMed id 10719184)1, 3 Serru V.... Rubinstein E. (Biochim. Biophys. Acta 2000)
    6. MiR-200a enhances the migrations of A549 and SK-MES-1 cells by regulating the expression of TSPAN1. (PubMed id 23938385)1 Chen Y....Xi T. (J. Biosci. 2013)
    7. Tetraspanin 1 promotes invasiveness of cervical cancer cells. (PubMed id 23754316)1 HAPlters S....Rubio I. (Int. J. Oncol. 2013)
    8. The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line. (PubMed id 22378020)1 Wang G.L....Zhu Y.Y. (Oncol. Rep. 2012)
    9. Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach. (PubMed id 20680643)1 Desouki M.M....Geradts J. (J. Cancer Res. Clin. Oncol. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10103 HGNC: 20657 AceView: TSPAN-1 Ensembl:ENSG00000117472 euGenes: HUgn10103
    ECgene: TSPAN1 H-InvDB: TSPAN1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPAN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPAN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPAN1 gene:
    Search GeneIP for patents involving TSPAN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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