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Aliases for TSPAN1 Gene

Aliases for TSPAN1 Gene

  • Tetraspanin 1 2 3
  • NET1 3 6
  • Tetraspanin TM4-C 4
  • Tetraspan NET-1 4
  • Tetraspanin-1 3
  • Tetraspan 1 3
  • Tspan-1 4
  • TM4SF 3
  • TM4C 3

External Ids for TSPAN1 Gene

Previous GeneCards Identifiers for TSPAN1 Gene

  • GC01P046360
  • GC01P046640
  • GC01P044755

Summaries for TSPAN1 Gene

Entrez Gene Summary for TSPAN1 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN1 Gene

TSPAN1 (Tetraspanin 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. An important paralog of this gene is TSPAN9.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN1 Gene

Genomics for TSPAN1 Gene

Regulatory Elements for TSPAN1 Gene

Genomic Location for TSPAN1 Gene

46,175,073 bp from pter
46,185,962 bp from pter
10,890 bases
Plus strand

Genomic View for TSPAN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN1 Gene

Proteins for TSPAN1 Gene

  • Protein details for TSPAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DQ14
    • O60745
    • Q5VST0

    Protein attributes for TSPAN1 Gene

    241 amino acids
    Molecular mass:
    26301 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN1 Gene

Proteomics data for TSPAN1 Gene at MOPED

Post-translational modifications for TSPAN1 Gene

  • Glycosylation at Asn141, Asn154, Asn178, and Asn184
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TSPAN1 Gene

Domains for TSPAN1 Gene

Gene Families for TSPAN1 Gene

Suggested Antigen Peptide Sequences for TSPAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN1: view

Function for TSPAN1 Gene

Gene Ontology (GO) - Molecular Function for TSPAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21836059
GO:0015403 thiamine uptake transmembrane transporter activity IDA 21836059
genes like me logo Genes that share ontologies with TSPAN1: view

Phenotypes for TSPAN1 Gene

GenomeRNAi human phenotypes for TSPAN1:
genes like me logo Genes that share phenotypes with TSPAN1: view

Animal Model Products

miRNA for TSPAN1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN1 Gene

Localization for TSPAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN1 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TSPAN1 Gene COMPARTMENTS Subcellular localization image for TSPAN1 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12115476
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005886 plasma membrane IDA 21836059
GO:0016020 membrane IDA 12115476
genes like me logo Genes that share ontologies with TSPAN1: view

Pathways for TSPAN1 Gene

genes like me logo Genes that share pathways with TSPAN1: view

Interacting Proteins for TSPAN1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: O60635-TSN1_HUMAN ENSP00000361072 for TSPAN1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TSPAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IDA 22378020
GO:0016477 cell migration IMP 22378020
GO:0045807 positive regulation of endocytosis IMP 22378020
GO:0050821 protein stabilization IDA 21836059
GO:0071934 thiamine transmembrane transport IDA 21836059
genes like me logo Genes that share ontologies with TSPAN1: view

Transcripts for TSPAN1 Gene

Unigene Clusters for TSPAN1 Gene

Tetraspanin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPAN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - -
SP10: -

Relevant External Links for TSPAN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN1 Gene

mRNA expression in normal human tissues for TSPAN1 Gene

mRNA differential expression in normal tissues according to GTEx for TSPAN1 Gene

This gene is overexpressed in Colon - Transverse (17.4) and Kidney - Cortex (10.6).

Protein differential expression in normal tissues for TSPAN1 Gene

This gene is overexpressed in Urine (35.9) and Cervix (22.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN1 Gene

SOURCE GeneReport for Unigene cluster for TSPAN1 Gene Hs.38972

genes like me logo Genes that share expressions with TSPAN1: view

Expression partners for TSPAN1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN1 Gene

Orthologs for TSPAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPAN1 35
  • 86.31 (n)
  • 81.33 (a)
  • 81 (a)
(Canis familiaris)
Mammalia TSPAN1 35
  • 84.92 (n)
  • 80.91 (a)
  • 81 (a)
(Mus musculus)
Mammalia Tspan1 35
  • 80.56 (n)
  • 74.17 (a)
Tspan1 16
Tspan1 36
  • 73 (a)
(Pan troglodytes)
Mammalia TSPAN1 35
  • 99.72 (n)
  • 99.59 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan1 35
  • 79.53 (n)
  • 74.27 (a)
(Monodelphis domestica)
Mammalia TSPAN1 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN1 36
  • 47 (a)
(Gallus gallus)
Aves TSPAN1 35
  • 66.38 (n)
  • 61.7 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia TSPAN1 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan1 35
  • 62.34 (n)
  • 62.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24793 35
(Danio rerio)
Actinopterygii -- 35
zgc:64085 35
  • 58.63 (n)
  • 51.34 (a)
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea tsp-11 36
  • 19 (a)
tsp-13 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
CSA.10827 36
  • 35 (a)
CSA.5127 36
  • 33 (a)
CSA.8143 36
  • 33 (a)
Species with no ortholog for TSPAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN1 Gene

Gene Tree for TSPAN1 (if available)
Gene Tree for TSPAN1 (if available)

Paralogs for TSPAN1 Gene

Paralogs for TSPAN1 Gene

(12) SIMAP similar genes for TSPAN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN1: view

Variants for TSPAN1 Gene

Sequence variations from dbSNP and Humsavar for TSPAN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1047216 -- 46,185,086(+) GCACC(A/G)AGCAA reference, missense
rs1802309 -- 46,185,806(+) TAAAC(C/T)CTTGA utr-variant-3-prime
rs2234261 -- 46,180,291(+) GTGGA(A/G)GGCAC intron-variant
rs2234262 -- 46,180,313(+) GGGAA(A/G)CCACT intron-variant
rs2234265 -- 46,181,053(+) CAGGT(A/G)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN1 Gene

Variant ID Type Subtype PubMed ID
nsv527878 CNV Gain 19592680
nsv822520 CNV Loss 20364138

Relevant External Links for TSPAN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN1 Gene

Disorders for TSPAN1 Gene

Relevant External Links for TSPAN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TSPAN1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TSPAN1 Gene

Publications for TSPAN1 Gene

  1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 2 3 4
  2. Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. (PMID: 19139842) Lin X. … Mooser V. (Diabetologia 2009) 3 48
  3. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V. … Rubinstein E. (Biochim. Biophys. Acta 2000) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum. (PMID: 19508227) Scholz C.-J. … Deissler H. (Protein Pept. Lett. 2009) 3 4

Products for TSPAN1 Gene

Sources for TSPAN1 Gene

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