Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPAN1 Gene

protein-coding   GIFtS: 52
GCID: GC01P046640

tetraspanin 1
 Explore 10 diseases affiliated with
TSPAN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TSPAN1    

Aliases
for TSPAN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tetraspanin 11 2     Tetraspan 12
NET12 5     Tetraspanin-11
NET-11     Tspan-13
TSPAN-11     Tetraspan NET-13
TM4C2     Tetraspanin TM4-C3
TM4SF2     

External Ids:    HGNC: 206571   Entrez Gene: 101032   Ensembl: ENSG000001174727   OMIM: 6131705   UniProtKB: O606353   

Export aliases for TSPAN1 gene to outside databases

Previous GC identifers: GC01P046360 GC01P044755


Summaries
for TSPAN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TSPAN1:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.
The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,
growth and motility. (provided by RefSeq, Jul 2008)




Genomic Views
for TSPAN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPAN1 gene promoter:
         Bach1   AML1a   Hand1   HNF-4alpha2   HNF-4alpha1   Roaz   E47   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSPAN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPAN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33

TSPAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046640:  view genomic region     (about GC identifiers)

Start:
 46,640,745 bp from pter      End:
 46,651,634 bp from pter
Size:
 10,890 bases      Orientation:
 plus strand

Proteins
for TSPAN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSN1_HUMAN, O60635 (See protein sequence)
Recommended Name: Tetraspanin-1  
Size: 241 amino acids; 26301 Da
Subcellular location: Lysosome membrane; Multi-pass membrane protein
Secondary accessions: D3DQ14 O60745 Q5VST0

Explore the universe of human proteins at neXtProt for TSPAN1: NX_O60635

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60635

    • TSPAN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005718.2  
    ENSEMBL proteins: 
     ENSP00000361072  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TSPAN1
    OriGene Custom Protein Services for TSPAN1 
    GenScript Custom Purified and Recombinant Proteins Services for TSPAN1
    Novus Biologicals TSPAN1 Proteins
    Novus Biologicals TSPAN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TSPAN1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral to membrane IEA--


    TSPAN1 for ontologies           About GeneDecksing



    TSPAN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): TSPAN1
    OriGene Custom Antibody Services for TSPAN1 
    GenScript Custom Superior Antibodies Services for TSPAN1
    Novus Biologicals TSPAN1 Antibodies
    Abcam antibodies for TSPAN1 
    Uscn Antibodies for TSPAN1
    ThermoFisher Antibody for TSPAN1

    Assay Products for TSPAN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSPAN1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TSPAN1

    Protein Domains /
    Families
    for TSPAN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TSPAN1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018499 Tetraspanin/Peripherin
     IPR018503 Tetraspanin_CS
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2

    Graphical View of Domain Structure for InterPro Entry O60635

    ProtoNet protein and cluster: O60635

    1 Blocks protein family: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN1_HUMAN, O60635
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Function
    for TSPAN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone: TSPAN1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN1:
    hsa-miR-361-3p hsa-miR-450b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TSPAN1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN1 (see all 7)
    OriGene shRNA RFP: TSPAN1
    OriGene siRNA: TSPAN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TSPAN1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TSPAN1 (NM_005727)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TSPAN1
    Search LifeMap BioReagents cell lines for TSPAN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN1

    1 GenomeRNAi human phenotype for TSPAN1:
     Decreased Wnt reporter activit 


    Pathways & Interactions
    for TSPAN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPAN1

    1 Interacting protein for TSPAN1 (O606353) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDKP217413I2D: score=1 
    About this table

    Drugs & Compounds
    for TSPAN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSPAN1
    Search CenterWatch for drugs/clinical trials and news about TSPAN1 / TSN1 

    Transcripts
    for TSPAN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSPAN1 gene: 
    NM_005727.3  

    Unigene Cluster for TSPAN1:

    Tetraspanin 1
    Hs.38972  [show with all ESTs]
    Unigene Representative Sequence: NM_005727
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498443 ENST00000372003(uc001cpd.3) ENST00000482928 ENST00000469330
    ENST00000475163 ENST00000486237 ENST00000464786 ENST00000482143 ENST00000472170
    ENST00000470318

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TSPAN1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPAN1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPAN1:
    hsa-miR-361-3p hsa-miR-450b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TSPAN1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN1 (see all 7)
    OriGene shRNA RFP: TSPAN1
    OriGene siRNA: TSPAN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TSPAN1 (NM_005727)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPAN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN1

    Additional cDNA sequence: 

    AF054838.1 AF065388.1 AF133425.1 AK313774.1 BC000695.2 BC007290.1 BC013404.2 

    18 DOTS entries:

    DT.95224341  DT.99988721  DT.453603  DT.99984995  DT.418611  DT.92033472  DT.100817377  DT.121350413 
    DT.75140879  DT.97859497  DT.121350404  DT.40209407  DT.92445712  DT.95262112  DT.100817378  DT.101956585 
    DT.121350501  DT.121350529 

    24/390 AceView cDNA sequences (see all 390):

    AA337915 AW970056 AW510543 AW316997 BM855837 AA877926 AI680497 AI459564 
    BC013404 AI674349 CB130238 BE249898 BI224427 BI763537 BM672756 BM856468 
    AI075023 BP342136 AI570835 AF065388 BM833257 BG547187 AW009945 AI670721 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN1 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
    SP1:                          -     -     -                             -                                                         
    SP2:                          -     -     -     -     -                 -                                                         
    SP3:                          -     -     -                             -     -     -                                             
    SP4:                                      -                             -                                                         
    SP5:                                                                    -                                                         


    ECgene alternative splicing isoforms for TSPAN1

    Expression
    for TSPAN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSPAN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAACTGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TSPAN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TSPAN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSPAN1

    SOURCE GeneReport for Unigene cluster: Hs.38972
        SABiosciences Custom PCR Arrays for TSPAN1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPAN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN1

    Orthologs
    for TSPAN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TSPAN11 tetraspanin 1 66.52(n)
    61.97(a)    		   424607  XM_422444.2  XP_422444.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TSPAN16
    		 --
    		 46(a)
    		 1 ↔ 1
    		 GL344207.1(53600-67323)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.247932 Xenopus laevis transcribed sequence with weak similarity more 72.8(n)    BU912851.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC054611.12   -- 77.17(n)   393380  BC054611.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea tsp-116
    		 TetraSPanin family member (tsp-11)
    		 17(a)
    		 1 → many
    		 X(9163107-9165950)


    ENSEMBL Gene Tree for TSPAN1 (if available)
    TreeFam Gene Tree for TSPAN1 (if available) 

    Paralogs
    for TSPAN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSPAN1 gene
    CD1512  CD372  TSPAN62  TSPAN92  TSPAN32  CD632  CD532  CD822  
    TSPAN182  TSPAN72  TSPAN42  TSPAN112  ENSG000002503492  TSPAN82  
    12 SIMAP similar genes for TSPAN1 using alignment to 1 protein entry:     TSN1_HUMAN:
    TSPAN18    TSPAN6    TSPAN8    CD82    TSPAN4    TSPAN16
    TM4SF2    TSPAN3    CD53    TSPAN11    TSPAN9    TSPAN7

    TSPAN1 for paralogs           About GeneDecksing



    Genomic Variants
    for TSPAN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/237 NCBI SNPs in TSPAN1 are shown (see all 237)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1148929161,2
    		--46638787(+) TGTGAG/AAAGGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1396288581,2
    		--46638934(+) GCAAAC/TGGAGC 1 -- us2k10--------
    rs1861178461,2
    		--46638971(+) CTCACA/GATTTA 1 -- us2k10--------
    rs558849401,2
    		C,F,--46639016(+) TCACTG/AAGCTA 1 -- us2k14Minor allele frequency- A:0.15NA WA 242
    rs1429058111,2
    		--46639115(+) TGACTA/GACACA 1 -- us2k10--------
    rs1461365811,2
    		--46639427(+) GAGATA/GATGTC 1 -- us2k10--------
    rs1892582011,2
    		--46639562(+) CACTCA/TTATAG 1 -- us2k10--------
    rs1159942031,2
    		F,--46639595(+) AGGGCC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1487939661,2
    		--46639710(+) GTGTCC/TGGGTG 1 -- us2k10--------
    rs1424753601,2
    		--46639753(+) CATGCA/GTATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSPAN1 (46640745 - 46651634 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TSPAN1: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN1
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN1

    Disorders / Diseases
    for TSPAN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TSPAN1 for disorders           About GeneDecksing

    OMIM gene information: 613170    OMIM disorders: --

    10 diseases for TSPAN1:    About MalaCards
    cervical intraepithelial neoplasia    squamous cell carcinoma    cervicitis    cervical carcinoma
    hepatocellular carcinoma    ovarian carcinoma    colon cancer    carcinoma
    breast cancer    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: TSPAN1 (1 document)

    Export disorders for TSPAN1 gene to outside databases

    Publications
    for TSPAN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSPAN1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with TSPAN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PubMed id 9714763)1, 2, 3 Todd S.C.... Levy S. (1998)
    2. Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum. (PubMed id 19508227)1, 2 Scholz C.-J.... Deissler H. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Sequence and expression of seven new tetraspans. (PubMed id 10719184)1, 3 Serru V.... Rubinstein E. (2000)
    5. The effect of NET-1 on the proliferation, migration an d endocytosis of the SMMC-7721 HCC cell line. (PubMed id 22378020)1 Wang G.L....Zhu Y.Y. (2012)
    6. Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach. (PubMed id 20680643)1 Desouki M.M....Geradts J. (2011)
    7. Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. (PubMed id 21836059)1 Nabokina S.M....Said H.M. (2011)
    8. Genomics of hepatitis B virus-related hepatocellular c arcinoma and adjacent noncancerous tissues with cDNA microarray. (PubMed id 22088470)1 Huang Y.K....Wang Z.M. (2011)
    9. Suppression of TSPAN1 by RNA interference inhibits pr oliferation and invasion of colon cancer cells in vitro. (PubMed id 21302622)1 Chen L....Zhu J. (2010)
    10. Clinicopathological significance of expression of Tsp an-1, Jab1 and p27 in human hepatocellular carcinoma. (PubMed id 20890423)1 Chen L....Zhu J. (2010)

    External Searches for TSPAN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TSPAN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10103 HGNC: 20657 AceView: TSPAN-1 Ensembl:ENSG00000117472 euGenes: HUgn10103
    ECgene: TSPAN1 H-InvDB: TSPAN1

    Other Databases showing TSPAN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TSPAN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSPAN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPAN1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TSPAN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TSPAN1 gene:
    Search GeneIP for patents involving TSPAN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TSPAN1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TSPAN1   OriGene shRNA RFP for TSPAN1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPAN1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPAN1  
     OriGene Protein Over-expression Lysate for TSPAN1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TSPAN1   OriGene 3'-UTR Clone for TSPAN1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPAN1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSPAN1   OriGene Custom Protein Services for TSPAN1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPAN1
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPAN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPAN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPAN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPAN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPAN1
     GenScript Custom Purified and Recombinant Proteins Services for TSPAN1 GenScript cDNA clones with any tag delivered in your preferred vector for TSPAN1
     GenScript Custom Assay Services for TSPAN1 GenScript Custom Superior Antibodies Services for TSPAN1
     GenScript Custom overexpressing Cell Line Services for TSPAN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSPAN1 promoter
     Search Chromatin IP Primers for TSPAN1
     RT2 qPCR Primer Assay in human, mouse, rat TSPAN1
     Search GNC Networks for TSPAN1
     SABiosciences Custom PCR Arrays for TSPAN1
     Search Tocris compounds for TSPAN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSPAN1 antibodies
     TSPAN1 proteins
     TSPAN1 lysates
     Antibodies for TSPAN1
     See all of Abcam's Antibodies, Kits and Proteins for TSPAN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TSPAN1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TSPAN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN1
     SwitchGear 3'UTR luciferase reporter plasmids for TSPAN1
     SwitchGear Promoter luciferase reporter plasmids for TSPAN1
     ThermoFisher Antibody for TSPAN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPAN1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TSPAN1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4