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Aliases for TSPAN1 Gene

Aliases for TSPAN1 Gene

  • Tetraspanin 1 2 3 5
  • Tetraspanin TM4-C 4
  • Tetraspan NET-1 4
  • Tetraspan 1 3
  • Tspan-1 4
  • TM4SF 3
  • NET1 3
  • TM4C 3

External Ids for TSPAN1 Gene

Previous GeneCards Identifiers for TSPAN1 Gene

  • GC01P046360
  • GC01P046640
  • GC01P044755

Summaries for TSPAN1 Gene

Entrez Gene Summary for TSPAN1 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN1 Gene

TSPAN1 (Tetraspanin 1) is a Protein Coding gene. GO annotations related to this gene include thiamine uptake transmembrane transporter activity. An important paralog of this gene is TSPAN9.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN1 Gene

Genomics for TSPAN1 Gene

Regulatory Elements for TSPAN1 Gene

Enhancers for TSPAN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN1 Gene

Chromosome:
1
Start:
46,175,073 bp from pter
End:
46,196,489 bp from pter
Size:
21,417 bases
Orientation:
Plus strand

Genomic View for TSPAN1 Gene

Genes around TSPAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN1 Gene

Proteins for TSPAN1 Gene

  • Protein details for TSPAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60635-TSN1_HUMAN
    Recommended name:
    Tetraspanin-1
    Protein Accession:
    O60635
    Secondary Accessions:
    • D3DQ14
    • O60745
    • Q5VST0

    Protein attributes for TSPAN1 Gene

    Size:
    241 amino acids
    Molecular mass:
    26301 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN1 Gene

Proteomics data for TSPAN1 Gene at MOPED

Post-translational modifications for TSPAN1 Gene

  • Glycosylation at Asn 141, Asn 154, Asn 178, and Asn 184
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TSPAN1 Gene

Domains & Families for TSPAN1 Gene

Gene Families for TSPAN1 Gene

Suggested Antigen Peptide Sequences for TSPAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60635

UniProtKB/Swiss-Prot:

TSN1_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN1: view

Function for TSPAN1 Gene

genes like me logo Genes that share phenotypes with TSPAN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN1 Gene

Localization for TSPAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN1 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN1 Gene COMPARTMENTS Subcellular localization image for TSPAN1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 3
vacuole 3

Gene Ontology (GO) - Cellular Components for TSPAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12115476
GO:0005765 lysosomal membrane IEA --
GO:0005886 plasma membrane IDA 21836059
GO:0016020 membrane IDA 12115476
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TSPAN1: view

Pathways & Interactions for TSPAN1 Gene

SuperPathways for TSPAN1 Gene

No Data Available

Interacting Proteins for TSPAN1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361072%0d%0a9606.ENSP00000352852%0d%0a9606.ENSP00000312988%0d%0a
Selected Interacting proteins: ENSP00000361072 O60635-TSN1_HUMAN for TSPAN1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TSPAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IMP 22378020
genes like me logo Genes that share ontologies with TSPAN1: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN1 Gene

Drugs & Compounds for TSPAN1 Gene

No Compound Related Data Available

Transcripts for TSPAN1 Gene

Unigene Clusters for TSPAN1 Gene

Tetraspanin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - -
SP10: -
SP11:

Relevant External Links for TSPAN1 Gene

GeneLoc Exon Structure for
TSPAN1
ECgene alternative splicing isoforms for
TSPAN1

Expression for TSPAN1 Gene

mRNA expression in normal human tissues for TSPAN1 Gene

mRNA differential expression in normal tissues according to GTEx for TSPAN1 Gene

This gene is overexpressed in Colon - Transverse (x17.4) and Kidney - Cortex (x10.6).

Protein differential expression in normal tissues from HIPED for TSPAN1 Gene

This gene is overexpressed in Urine (35.9) and Cervix (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN1 Gene



SOURCE GeneReport for Unigene cluster for TSPAN1 Gene Hs.38972

genes like me logo Genes that share expression patterns with TSPAN1: view

Protein tissue co-expression partners for TSPAN1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TSPAN1 Gene

Orthologs for TSPAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSPAN1 35
  • 86.31 (n)
  • 81.33 (a)
TSPAN1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN1 35
  • 84.92 (n)
  • 80.91 (a)
TSPAN1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan1 35
  • 80.56 (n)
  • 74.17 (a)
Tspan1 16
Tspan1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSPAN1 35
  • 99.72 (n)
  • 99.59 (a)
TSPAN1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan1 35
  • 79.53 (n)
  • 74.27 (a)
oppossum
(Monodelphis domestica)
Mammalia TSPAN1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN1 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN1 35
  • 66.38 (n)
  • 61.7 (a)
TSPAN1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan1 35
  • 62.34 (n)
  • 62.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24793 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
zgc:64085 35
  • 58.63 (n)
  • 51.34 (a)
TSPAN1 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-11 36
  • 19 (a)
ManyToMany
tsp-13 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
CSA.10827 36
  • 35 (a)
ManyToMany
CSA.5127 36
  • 33 (a)
ManyToMany
CSA.8143 36
  • 33 (a)
ManyToMany
Species with no ortholog for TSPAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN1 Gene

ENSEMBL:
Gene Tree for TSPAN1 (if available)
TreeFam:
Gene Tree for TSPAN1 (if available)

Paralogs for TSPAN1 Gene

Paralogs for TSPAN1 Gene

(12) SIMAP similar genes for TSPAN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPAN1: view

Variants for TSPAN1 Gene

Sequence variations from dbSNP and Humsavar for TSPAN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2234268 - 46,184,392(+) CCCTC(A/G)TGACG reference, missense
rs2234267 - 46,184,246(+) GGCAT(C/T)CTTTC reference, missense
rs1047216 -- 46,185,086(+) GCACC(A/G)AGCAA reference, missense
rs1802309 -- 46,185,806(+) TAAAC(C/T)CTTGA intron-variant, utr-variant-3-prime
rs1802371 -- 46,185,624(+) CAGGA(C/T)CTAAC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TSPAN1 Gene

Variant ID Type Subtype PubMed ID
nsv527878 CNV Gain 19592680
nsv822520 CNV Loss 20364138

Variation tolerance for TSPAN1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN1 Gene

Disorders for TSPAN1 Gene

Relevant External Links for TSPAN1

Genetic Association Database (GAD)
TSPAN1
Human Genome Epidemiology (HuGE) Navigator
TSPAN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN1

No disorders were found for TSPAN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN1 Gene

Publications for TSPAN1 Gene

  1. Sequences and expression of six new members of the tetraspanin/TM4SF family. (PMID: 9714763) Todd S.C. … Levy S. (Biochim. Biophys. Acta 1998) 2 3 4 67
  2. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V. … Rubinstein E. (Biochim. Biophys. Acta 2000) 2 3
  3. TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573. (PMID: 26054975) Lu Z. … Xue X. (FEBS Lett. 2015) 3
  4. MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma. (PMID: 25301729) Zhang J. … Huang Z. (Oncotarget 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for TSPAN1 Gene

Sources for TSPAN1 Gene

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