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Aliases for TSNAXIP1 Gene

Aliases for TSNAXIP1 Gene

  • Translin Associated Factor X Interacting Protein 1 2 3 5
  • Trax-Interacting Protein 1 3 4
  • TXI1 3 4
  • Translin-Associated Factor X Interacting Protein 1 2
  • Translin-Associated Factor X-Interacting Protein 1 3

External Ids for TSNAXIP1 Gene

Previous GeneCards Identifiers for TSNAXIP1 Gene

  • GC16P058535
  • GC16P068218
  • GC16P067577
  • GC16P067617
  • GC16P066398
  • GC16P067840
  • GC16P053713

Summaries for TSNAXIP1 Gene

GeneCards Summary for TSNAXIP1 Gene

TSNAXIP1 (Translin Associated Factor X Interacting Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TSNAXIP1 Gene

  • Possible role in spermatogenesis.

Additional gene information for TSNAXIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSNAXIP1 Gene

Genomics for TSNAXIP1 Gene

Regulatory Elements for TSNAXIP1 Gene

Enhancers for TSNAXIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H067854 1.7 FANTOM5 Ensembl ENCODE 11.2 +50.5 50520 4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TCF12 ZNF121 ZNF143 RANBP10 ACD NFATC3 NRN1L TSNAXIP1 DUS2 PSKH1 E2F4 SLC12A4 PARD6A
GH16H068263 1.4 ENCODE dbSUPER 12 +458.3 458337 3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 PRMT7 ZFP90 CTCF SNTB2 ZDHHC1 SLC12A4 SLC7A6 LOC100131303 RNU4-36P ENSG00000265113
GH16H067555 1.5 Ensembl ENCODE dbSUPER 9.7 -250.3 -250348 1 ZNF493 ZFP64 ZNF121 FOS KLF7 ZNF202 ZC3H11A REST ZNF623 ZNF518A ZDHHC1 EDC4 CENPT ENSG00000260465 CTCF ENKD1 NAE1 E2F4 ENSG00000263276 ACD
GH16H067860 1.3 FANTOM5 Ensembl ENCODE 11 +55.6 55649 4 PKNOX1 KLF1 FOSL1 ZNF664 ZNF121 GATA3 SCRT2 FOSL2 FOS ZNF600 NRN1L THAP11 PSKH1 RANBP10 TSNAXIP1 RIPOR1 PRMT7 ACD PARD6A CARMIL2
GH16H067772 1.1 Ensembl ENCODE 11.5 -32.9 -32926 1 FOXA2 RAD21 YY1 TCF12 ZNF766 SCRT2 REST ZEB2 NR2F2 SMARCA4 DUS2 GFOD2 TSNAXIP1 RANBP10 THAP11 CENPT ACD PARD6A EDC4 CARMIL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSNAXIP1 on UCSC Golden Path with GeneCards custom track

Promoters for TSNAXIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087180 -56 1601 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143

Genomic Location for TSNAXIP1 Gene

Chromosome:
16
Start:
67,806,656 bp from pter
End:
67,832,148 bp from pter
Size:
25,493 bases
Orientation:
Plus strand

Genomic View for TSNAXIP1 Gene

Genes around TSNAXIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSNAXIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSNAXIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSNAXIP1 Gene

Proteins for TSNAXIP1 Gene

  • Protein details for TSNAXIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAA8-TXIP1_HUMAN
    Recommended name:
    Translin-associated factor X-interacting protein 1
    Protein Accession:
    Q2TAA8
    Secondary Accessions:
    • Q9P105

    Protein attributes for TSNAXIP1 Gene

    Size:
    658 amino acids
    Molecular mass:
    76773 Da
    Quaternary structure:
    • Interacts with TSNAX.

    Alternative splice isoforms for TSNAXIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSNAXIP1 Gene

Post-translational modifications for TSNAXIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSNAXIP1 Gene

Domains & Families for TSNAXIP1 Gene

Gene Families for TSNAXIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSNAXIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSNAXIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSNAXIP1: view

No data available for UniProtKB/Swiss-Prot for TSNAXIP1 Gene

Function for TSNAXIP1 Gene

Molecular function for TSNAXIP1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for TSNAXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TSNAXIP1: view

Phenotypes for TSNAXIP1 Gene

genes like me logo Genes that share phenotypes with TSNAXIP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TSNAXIP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSNAXIP1 Gene

Localization for TSNAXIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSNAXIP1 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSNAXIP1 gene
Compartment Confidence
cytosol 2
nucleus 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSNAXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSNAXIP1: view

Pathways & Interactions for TSNAXIP1 Gene

SuperPathways for TSNAXIP1 Gene

No Data Available

Interacting Proteins for TSNAXIP1 Gene

Gene Ontology (GO) - Biological Process for TSNAXIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSNAXIP1: view

No data available for Pathways by source and SIGNOR curated interactions for TSNAXIP1 Gene

Drugs & Compounds for TSNAXIP1 Gene

No Compound Related Data Available

Transcripts for TSNAXIP1 Gene

Unigene Clusters for TSNAXIP1 Gene

Translin-associated factor X interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TSNAXIP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TSNAXIP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1:
SP2: - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - - - - - - -
SP9: - - - -

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TSNAXIP1 Gene

GeneLoc Exon Structure for
TSNAXIP1
ECgene alternative splicing isoforms for
TSNAXIP1

Expression for TSNAXIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSNAXIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSNAXIP1 Gene

This gene is overexpressed in Testis (x8.6) and Pituitary (x5.3).

Protein differential expression in normal tissues from HIPED for TSNAXIP1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (42.0), Cervix (19.5), and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSNAXIP1 Gene



Protein tissue co-expression partners for TSNAXIP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSNAXIP1 Gene:

TSNAXIP1

SOURCE GeneReport for Unigene cluster for TSNAXIP1 Gene:

Hs.632212
genes like me logo Genes that share expression patterns with TSNAXIP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSNAXIP1 Gene

Orthologs for TSNAXIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSNAXIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSNAXIP1 33 34
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia TSNAXIP1 33 34
  • 87.03 (n)
cow
(Bos Taurus)
Mammalia TSNAXIP1 34 33
  • 86.26 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsnaxip1 33
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Tsnaxip1 16 34 33
  • 79.78 (n)
oppossum
(Monodelphis domestica)
Mammalia TSNAXIP1 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves TSNAXIP1 33 34
  • 59.71 (n)
lizard
(Anolis carolinensis)
Reptilia TSNAXIP1 34
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tsnaxip1 33 34
  • 50.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToOne
Species where no ortholog for TSNAXIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSNAXIP1 Gene

ENSEMBL:
Gene Tree for TSNAXIP1 (if available)
TreeFam:
Gene Tree for TSNAXIP1 (if available)

Paralogs for TSNAXIP1 Gene

No data available for Paralogs for TSNAXIP1 Gene

Variants for TSNAXIP1 Gene

Sequence variations from dbSNP and Humsavar for TSNAXIP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs193921053 Uncertain significance 67,827,340(+) GCAAT(A/G)CAGAC reference, missense
rs1000009892 -- 67,814,039(+) ATGGG(A/G)TTCTC intron-variant
rs1000051477 -- 67,805,252(+) CACTG(C/G)CCATC intron-variant, upstream-variant-2KB
rs1000103529 -- 67,804,846(+) TTTAA(G/T)GAGGA intron-variant, upstream-variant-2KB
rs1000185739 -- 67,824,185(+) TTCCA(C/T)GATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSNAXIP1 Gene

Variant ID Type Subtype PubMed ID
dgv502e199 CNV deletion 23128226
nsv1127510 CNV deletion 24896259
nsv1131266 CNV deletion 24896259
nsv1131268 CNV deletion 24896259
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv572907 CNV loss 21841781

Variation tolerance for TSNAXIP1 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSNAXIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSNAXIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSNAXIP1 Gene

Disorders for TSNAXIP1 Gene

Relevant External Links for TSNAXIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSNAXIP1

No disorders were found for TSNAXIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSNAXIP1 Gene

Publications for TSNAXIP1 Gene

  1. Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. (PMID: 12036294) Bray JD … Hecht NB (Genomics 2002) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 60
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 60
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 60

Products for TSNAXIP1 Gene

Sources for TSNAXIP1 Gene

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