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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSNAXIP1 Gene

protein-coding   GIFtS: 38
GCID: GC16P067840

Translin-Associated Factor X Interacting Protein 1

  Search for TSNAXIP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translin-Associated Factor X Interacting Protein 11 2
Trax-Interacting Protein 12 3
TXI12 3
Translin-Associated Factor X-Interacting Protein 12

External Ids:    HGNC: 185861   Entrez Gene: 558152   Ensembl: ENSG000001029047   OMIM: 6077205   UniProtKB: Q2TAA83   

Export aliases for TSNAXIP1 gene to outside databases

Previous GC identifers: GC16P058535 GC16P068218 GC16P067577 GC16P067617 GC16P066398 GC16P053713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSNAXIP1 Gene: 
TSNAXIP1 (translin-associated factor X interacting protein 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: TXIP1_HUMAN, Q2TAA8
Function: Possible role in spermatogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSNAXIP1 gene promoter:
         Nkx3-1   AML1a   Tal-1   MIF-1   E47   Nkx3-1 v2   Egr-2   NRF-2   ATF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSNAXIP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSNAXIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSNAXIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.2

TSNAXIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSNAXIP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067840:  view genomic region     (about GC identifiers)

Start:
67,840,668 bp from pter      End:
67,866,051 bp from pter
Size:
25,384 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TXIP1_HUMAN, Q2TAA8 (See protein sequence)
Recommended Name: Translin-associated factor X-interacting protein 1  
Size: 658 amino acids; 76773 Da
Subunit: Interacts with TSNAX (By similarity)
Subcellular location: Cytoplasm, perinuclear region (By similarity)
Secondary accessions: Q9P105
Alternative splicing: 2 isoforms:  Q2TAA8-1   Q2TAA8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSNAXIP1: NX_Q2TAA8

Explore proteomics data for TSNAXIP1 at MOPED 

TSNAXIP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TSNAXIP1 Protein Expression

REFSEQ proteins: NP_060900.2  
ENSEMBL proteins: 
 ENSP00000411472   ENSP00000458938   ENSP00000455640   ENSP00000455011   ENSP00000457241  
 ENSP00000463792   ENSP00000454989   ENSP00000373485   ENSP00000464694   ENSP00000397147  
 ENSP00000464527  

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Novus Biologicals TSNAXIP1 Lysate
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Cloud-Clone Corp. Proteins for TSNAXIP1 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0048471perinuclear region of cytoplasm IEA--

TSNAXIP1 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TSNAXIP1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q2TAA8


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TXIP1_HUMAN, Q2TAA8
Function: Possible role in spermatogenesis (By similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
TSNAXIP1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TSNAXIP1 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSNAXIP1 
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miRNA
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Gene Editing
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSNAXIP1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TSNAXIP1 (Q2TAA83 ENSP000003734854) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TSNAXQ995983, ENSP000003555994I2D: score=4 STRING: ENSP00000355599
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007275multicellular organismal development IEA--
GO:0007283spermatogenesis IEA--
GO:0030154cell differentiation IEA--

TSNAXIP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSNAXIP1 (TXIP1)

Search CenterWatch for drugs/clinical trials and news about TSNAXIP1 / TXIP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSNAXIP1 gene: 
NM_018430.2  

Unigene Cluster for TSNAXIP1:

Translin-associated factor X interacting protein 1
Hs.632212  [show with all ESTs]
Unigene Representative Sequence: BC111018
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000415766 ENST00000466164 ENST00000568990(uc010cep.2 uc010vkb.2 uc002eug.4 uc002euh.4 uc002eui.4 uc002euk.3)
ENST00000487120(uc010vjz.1) ENST00000565339 ENST00000563363 ENST00000561639(uc010vka.2)
ENST00000567852 ENST00000565148 ENST00000388833(uc002euj.3) ENST00000562633
ENST00000561654 ENST00000569504(uc002euf.4) ENST00000431934 ENST00000562321
ENST00000565558
miRNA
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Inhib. RNA
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OriGene RNAi products in human, mouse, rat for TSNAXIP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSNAXIP1
Clone
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OriGene ORF clones in mouse, rat for TSNAXIP1
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSNAXIP1

Additional mRNA sequence: 

AK027245.1 AK301920.1 AK302300.1 AK303841.1 BC111018.1 BC131578.1 

9 DOTS entries:

DT.95162345  DT.97800511  DT.426358  DT.75160452  DT.95162346  DT.92070628  DT.101982969  DT.120718362 
DT.120718475 

24/37 AceView cDNA sequences (see all 37):

BU607826 AU279421 BC035320 BC050693 BC051766 BX281228 CA440141 AI928510 
BP371196 AI808713 BC062628 AL040508 BI833405 BI825840 AL040509 AI201021 
BG679364 BI756600 NM_018430 BI826170 BM545958 AI702580 BU607634 AL048883 

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TSNAXIP1 (see all 9)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1:                                                                                                                                                            
SP2:                                                  -           -                 -                                                                           
SP3:                                                  -           -     -     -     -                                                                           
SP4:                                                  -           -     -     -     -     -     -                                                               
SP5:                                                  -           -                                                                                             

ExUns: 15 ^ 16
SP1:            
SP2:            
SP3:            
SP4:            
SP5:            


ECgene alternative splicing isoforms for TSNAXIP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSNAXIP1 expression in normal human tissues (normalized intensities)      TSNAXIP1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCCAGGCCT
TSNAXIP1 Expression
About this image


TSNAXIP1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Pancreas (Endocrine System)
         Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
 
 Eye (Sensory Organs)
         retinal progenitor cell e12.5   
 
 Testis (Reproductive System)

See TSNAXIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSNAXIP1

SOURCE GeneReport for Unigene cluster: Hs.632212
    SABiosciences Custom PCR Arrays for TSNAXIP1
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSNAXIP1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSNAXIP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TSNAXIP1 gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tsnaxip11 , 5 translin-associated factor X (Tsnax) interacting protein more1, 5 80.6(n)1
77.36(a)1
  8 (53.04 cM)5
722361  NM_024445.41  NP_077765.11 
 1058277445 
chicken
(Gallus gallus)
Aves TSNAXIP11 translin-associated factor X interacting protein 1 59.7(n)
51.15(a)
  769262  XM_001232497.2  XP_001232498.2 
lizard
(Anolis carolinensis)
Reptilia TSNAXIP16
Uncharacterized protein
52(a)
1 ↔ 1
GL343295.1(692209-699057)
zebrafish
(Danio rerio)
Actinopterygii tsnaxip11 translin-associated factor X interacting protein 1 50.37(n)
37.39(a)
  565917  NM_001100100.1  NP_001093570.1 


ENSEMBL Gene Tree for TSNAXIP1 (if available)
TreeFam Gene Tree for TSNAXIP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/426 SNPs in TSNAXIP1 are shown (see all 426)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1821314831,2
--67842556(+) GAATCA/GCTTGA 1 -- int10--------
rs1858452561,2
--67842606(+) TCACGC/GCACTG 1 -- int10--------
rs1466937181,2
--67842699(+) AAAGAC/GAATTG 1 -- int10--------
rs594881591,2
C--67842731(+) TAGTAG/AACTGC 1 -- int11Minor allele frequency- A:0.50WA 2
rs1909928291,2
--67842840(+) ATCCCA/GATACT 1 -- int10--------
rs80476311,2
C,F--67843046(+) ttgtaG/Tcctgg 1 -- int11Minor allele frequency- T:0.18WA 118
rs1391227591,2
C--67843070(+) CCCTG-/TTGTCTA 1 -- int10--------
rs1474605071,2
C--67843095(+) TGGCCA/GGGCGT 1 -- int10--------
rs80475111,2
C,F--67843145(+) aggtgG/Cgcgga 1 -- int13Minor allele frequency- C:0.33NA 6
rs80475121,2
C,F--67843147(+) gtgcgT/Cggatc 1 -- int13Minor allele frequency- C:0.33NA 6

HapMap Linkage Disequilibrium report for TSNAXIP1 (67840668 - 67866051 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TSNAXIP1:    About this table     
Variant IDTypeSubtypePubMed ID
dgv502e199CNV Deletion23128226
nsv524363CNV Loss19592680
nsv522852CNV Gain19592680

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TSNAXIP1 for disorders           About MalaCards
OMIM gene information: 607720    OMIM disorders: --


TSNAXIP1 for disorders           About GeneDecksing


Export disorders for TSNAXIP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TSNAXIP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSNAXIP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. (PubMed id 12036294)1, 3 Bray J.D.... Hecht N.B. (2002)
  2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
  3. Lack of association between translin-associated facto r X gene (TSNAX) and methamphetamine dependence in the Japanese population. (PubMed id 21683752)1 Kishi T....Iwata N. (2011)
  4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 55815 HGNC: 18586 AceView: TSNAXIP1 Ensembl:ENSG00000102904 euGenes: HUgn55815
ECgene: TSNAXIP1 H-InvDB: TSNAXIP1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TSNAXIP1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TSNAXIP1 gene:
Search GeneIP for patents involving TSNAXIP1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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