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Aliases for TSNAX-DISC1 Gene

Subcategory (RNA class) for TSNAX-DISC1 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for TSNAX-DISC1 Gene

  • TSNAX-DISC1 Readthrough (NMD Candidate) 2 3

External Ids for TSNAX-DISC1 Gene

Previous GeneCards Identifiers for TSNAX-DISC1 Gene

  • GC00U928277
  • GC01U902499
  • GC01P202147
  • GC01P231665

Summaries for TSNAX-DISC1 Gene

Entrez Gene Summary for TSNAX-DISC1 Gene

  • This gene represents naturally occurring read-through transcription between the neighboring TSNAX (translin-associated factor X) and DISC1 (disrupted in schizophrenia 1) genes on chromosome 1. Alternative splicing results in multiple transcript variants, all of which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. These alterations in gene processing may be associated with risk for psychiatric illness, most notably, schizophrenia. [provided by RefSeq, Nov 2010]

GeneCards Summary for TSNAX-DISC1 Gene

TSNAX-DISC1 (TSNAX-DISC1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with TSNAX-DISC1 include schizophrenia. An important paralog of this gene is TSNAX.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSNAX-DISC1 Gene

Genomics for TSNAX-DISC1 Gene

Genomic Location for TSNAX-DISC1 Gene

Start:
231,528,653 bp from pter
End:
232,041,272 bp from pter
Size:
512,620 bases
Orientation:
Plus strand

Genomic View for TSNAX-DISC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSNAX-DISC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSNAX-DISC1 Gene

No data available for Regulatory Elements for TSNAX-DISC1 Gene

Proteins for TSNAX-DISC1 Gene

  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C4P0D4
    Recommended name:
    Disrupted in schizophrenia 1 isoform 47
    Protein Accession:
    C4P0D4
    Secondary Accessions:

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    138 amino acids
    Molecular mass:
    16111 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C4P0D6
    Recommended name:
    Disrupted in schizophrenia 1 isoform 49
    Protein Accession:
    C4P0D6
    Secondary Accessions:

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    186 amino acids
    Molecular mass:
    21427 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C4P0D8
    Recommended name:
    Disrupted in schizophrenia 1 isoform 51
    Protein Accession:
    C4P0D8
    Secondary Accessions:

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    188 amino acids
    Molecular mass:
    21477 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q9NRI2
    Recommended name:
    Disrupted in schizophrenia 1 isoform 52
    Protein Accession:
    Q9NRI2
    Secondary Accessions:

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    40 amino acids
    Molecular mass:
    4575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSNAX-DISC1 Gene

Proteomics data for TSNAX-DISC1 Gene at MOPED

Post-translational modifications for TSNAX-DISC1 Gene

No Post-translational modifications

Other Protein References for TSNAX-DISC1 Gene

No data available for DME Specific Peptides for TSNAX-DISC1 Gene

Domains for TSNAX-DISC1 Gene

Protein Domains for TSNAX-DISC1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSNAX-DISC1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TSNAX-DISC1 Gene

Function for TSNAX-DISC1 Gene

Gene Ontology (GO) - Molecular Function for TSNAX-DISC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with TSNAX-DISC1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSNAX-DISC1 Gene

Localization for TSNAX-DISC1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TSNAX-DISC1 Gene

Pathways for TSNAX-DISC1 Gene

SuperPathways for TSNAX-DISC1 Gene

No Data Available

Interacting Proteins for TSNAX-DISC1 Gene

Gene Ontology (GO) - Biological Process for TSNAX-DISC1 Gene

None

No data available for Pathways by source for TSNAX-DISC1 Gene

Transcripts for TSNAX-DISC1 Gene

mRNA/cDNA for TSNAX-DISC1 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TSNAX-DISC1
    • Block miRNA regulation of TSNAX-DISC1 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for TSNAX-DISC1

    Primer Products

    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX-DISC1 Gene

    No ASD Table

    Relevant External Links for TSNAX-DISC1 Gene

    GeneLoc Exon Structure for
    TSNAX-DISC1
    ECgene alternative splicing isoforms for
    TSNAX-DISC1

    Expression for TSNAX-DISC1 Gene

    mRNA expression in normal human tissues for TSNAX-DISC1 Gene

    mRNA differential expression in normal tissues according to GTEx for TSNAX-DISC1 Gene

    This gene is overexpressed in Testis (6.4).

    Integrated Proteomics: protein expression from for TSNAX-DISC1 Gene

    genes like me logo Genes that share expressions with TSNAX-DISC1: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TSNAX-DISC1 Gene

    Orthologs for TSNAX-DISC1 Gene

    This gene was present in the common ancestor of animals.

    Orthologs for TSNAX-DISC1 Gene

    Organism Taxonomy Gene Similarity Type Details
    cow
    (Bos Taurus)
    Mammalia TSNAX 36
    • 56 (a)
    OneToMany
    dog
    (Canis familiaris)
    Mammalia -- 36
    • 56 (a)
    ManyToMany
    oppossum
    (Monodelphis domestica)
    Mammalia -- 36
    • 43 (a)
    OneToMany
    platypus
    (Ornithorhynchus anatinus)
    Mammalia -- 36
    • 46 (a)
    OneToMany
    chicken
    (Gallus gallus)
    Aves TSNAX 36
    • 78 (a)
    OneToMany
    lizard
    (Anolis carolinensis)
    Reptilia -- 36
    • 44 (a)
    OneToMany
    zebrafish
    (Danio rerio)
    Actinopterygii tsnax 36
    • 37 (a)
    OneToMany
    fruit fly
    (Drosophila melanogaster)
    Insecta Trax 36
    • 20 (a)
    OneToMany
    Species with no ortholog for TSNAX-DISC1:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • chimpanzee (Pan troglodytes)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • corn (Zea mays)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • mouse (Mus musculus)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • rainbow trout (Oncorhynchus mykiss)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)

    Evolution for TSNAX-DISC1 Gene

    ENSEMBL:
    Gene Tree for TSNAX-DISC1 (if available)
    TreeFam:
    Gene Tree for TSNAX-DISC1 (if available)

    Paralogs for TSNAX-DISC1 Gene

    Paralogs for TSNAX-DISC1 Gene

    genes like me logo Genes that share paralogs with TSNAX-DISC1: view

    Variants for TSNAX-DISC1 Gene

    Sequence variations from dbSNP and Humsavar for TSNAX-DISC1 Gene

    SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
    rs1025526 -- 231,614,895(-) CTGAA(A/G)TGTAT intron-variant
    rs1025527 -- 231,614,099(-) GCAGC(C/T)GCCTA intron-variant
    rs1030710 -- 231,620,523(-) aagag(A/G)tgtag intron-variant
    rs1030711 -- 231,619,715(-) CACTC(A/T)CCATT intron-variant
    rs1612154 -- 231,589,122(+) TGGGA(A/G)CCAAG intron-variant

    Structural Variations from Database of Genomic Variants (DGV) for TSNAX-DISC1 Gene

    Variant ID Type Subtype PubMed ID
    nsv873293 CNV Gain 21882294
    dgv544n71 CNV Loss 21882294
    dgv187e1 CNV Complex 17122850
    nsv516935 CNV Gain 19592680
    esv2724872 CNV Deletion 23290073
    nsv873296 CNV Gain 21882294
    nsv8902 CNV Gain 18304495
    nsv873297 CNV Loss 21882294
    nsv468338 CNV Gain 19166990
    nsv4821 CNV Insertion 18451855
    dgv188e1 CNV Complex 17122850
    esv2656516 CNV Deletion 23128226
    nsv4832 CNV Insertion 18451855
    dgv545n71 CNV Loss 21882294
    nsv873300 CNV Loss 21882294
    esv2724883 CNV Deletion 23290073
    esv1761772 CNV Insertion 17803354
    esv2724894 CNV Deletion 23290073
    esv2724905 CNV Deletion 23290073
    esv2672018 CNV Deletion 23128226
    esv2724917 CNV Deletion 23290073
    nsv509646 CNV Insertion 20534489
    nsv4843 CNV Insertion 18451855
    esv272656 CNV Insertion 20981092
    esv271157 CNV Insertion 20981092
    esv994187 CNV Insertion 20482838
    esv2657352 CNV Deletion 23128226
    esv2668388 CNV Deletion 23128226
    nsv4855 CNV Insertion 18451855
    esv2661657 CNV Deletion 23128226
    nsv468382 CNV Loss 19166990
    nsv873301 CNV Loss 21882294
    nsv827230 CNV Gain 20364138
    nsv528452 CNV Loss 19592680

    Relevant External Links for TSNAX-DISC1 Gene

    HapMap Linkage Disequilibrium report
    TSNAX-DISC1

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSNAX-DISC1 Gene

    Disorders for TSNAX-DISC1 Gene

    MalaCards: The human disease database

    MalaCards: The human disease database. (1) Diseases for TSNAX-DISC1 Gene including...

    Search for TSNAX-DISC1 Gene in MalaCards »
    genes like me logo Genes that share disorders with TSNAX-DISC1: view

    No data available for UniProtKB/Swiss-Prot for TSNAX-DISC1 Gene

    Publications for TSNAX-DISC1 Gene

    1. Chromosomal location and genomic structure of the human translin- associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. (PMID: 10945471) Millar J.K. … Porteous D.J. (Genomics 2000) 3
    2. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. (PMID: 19118814) Beecham G.W. … Pericak-Vance M.A. (Am. J. Hum. Genet. 2009) 3
    3. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. (PMID: 19255581) Schosser A. … McGuffin P. (Mol. Psychiatry 2010) 3
    4. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers J.E. … Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
    5. DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. (PMID: 19805229) Nakata K. … Kleinman J.E. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3

    Products for TSNAX-DISC1 Gene

    • QIAGEN qRT-PCR Assays for microRNAs that regulate TSNAX-DISC1
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat
      • Predesigned siRNA for gene silencing in human,mouse,rat for TSNAX-DISC1
      • Block miRNA regulation of TSNAX-DISC1 using miScript Target Protectors

      Sources for TSNAX-DISC1 Gene

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