Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSNAX-DISC1 Gene

Subcategory (RNA class) for TSNAX-DISC1 Gene


Quality Score for this RNA gene is


Aliases for TSNAX-DISC1 Gene

  • TSNAX-DISC1 Readthrough (NMD Candidate) 2 3 5

External Ids for TSNAX-DISC1 Gene

Previous GeneCards Identifiers for TSNAX-DISC1 Gene

  • GC00U928277
  • GC01U902499
  • GC01P202147
  • GC01P231665

Summaries for TSNAX-DISC1 Gene

Entrez Gene Summary for TSNAX-DISC1 Gene

  • This gene represents naturally occurring read-through transcription between the neighboring TSNAX (translin-associated factor X) and DISC1 (disrupted in schizophrenia 1) genes on chromosome 1. Alternative splicing results in multiple transcript variants, all of which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. These alterations in gene processing may be associated with risk for psychiatric illness, most notably, schizophrenia. [provided by RefSeq, Nov 2010]

GeneCards Summary for TSNAX-DISC1 Gene

TSNAX-DISC1 (TSNAX-DISC1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with TSNAX-DISC1 include Schizophrenia 1 and Schizophrenia. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is TSNAX.

Additional gene information for TSNAX-DISC1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSNAX-DISC1 Gene

Genomics for TSNAX-DISC1 Gene

GeneHancer (GH) Regulatory Elements for TSNAX-DISC1 Gene

Promoters and enhancers for TSNAX-DISC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I231527 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.4 396 3.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TSNAX ENSG00000233461 TSNAX-DISC1 C1orf131 COG2 DISC1 GNPAT EXOC8 SPRTN GC01P231515
GH01I231625 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.2 +98.9 98924 3.3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 IRF4 ZNF548 FOS SP3 SP5 DISC1 C1orf131 SPRTN ARV1 COG2 RNU5A-5P TSNAX-DISC1
GH01I231603 Enhancer 1.1 Ensembl ENCODE 0.2 +75.5 75505 1.2 PKNOX1 ARID4B SIN3A ZNF2 ZNF213 ARID2 ZNF143 KLF13 REST TSHZ1 C1orf131 DISC1 EGLN1 COG2 GNPAT SPRTN LINC00582 GC01P231590 GC01P231591 TSNAX-DISC1
GH01I231583 Enhancer 0.9 Ensembl ENCODE 0.2 +55.7 55676 0.8 CTCF ZNF654 RFX1 ARNT ZSCAN4 REST RAD21 IRF9 FOSL1 ZNF335 LINC00582 EGLN1 GC01P231590 GC01P231591 TSNAX TSNAX-DISC1 GC01P231515
GH01I231611 Enhancer 0.9 Ensembl ENCODE 0.2 +84.5 84486 2.5 PKNOX1 CBFB MAX JUNB ELF1 ZNF2 ATF2 POLR2A IKZF1 ATF7 LINC00582 DISC1 GC01P231616 TSNAX-DISC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSNAX-DISC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TSNAX-DISC1 Gene

Genomic Locations for TSNAX-DISC1 Gene
512,620 bases
Plus strand

Genomic View for TSNAX-DISC1 Gene

Genes around TSNAX-DISC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSNAX-DISC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSNAX-DISC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSNAX-DISC1 Gene

Proteins for TSNAX-DISC1 Gene

  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Disrupted in schizophrenia 1 isoform 47
    Protein Accession:

    Protein attributes for TSNAX-DISC1 Gene

    138 amino acids
    Molecular mass:
    16111 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Disrupted in schizophrenia 1 isoform 49
    Protein Accession:

    Protein attributes for TSNAX-DISC1 Gene

    186 amino acids
    Molecular mass:
    21427 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Disrupted in schizophrenia 1 isoform 51
    Protein Accession:

    Protein attributes for TSNAX-DISC1 Gene

    188 amino acids
    Molecular mass:
    21477 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Disrupted in schizophrenia 1 isoform 52
    Protein Accession:

    Protein attributes for TSNAX-DISC1 Gene

    40 amino acids
    Molecular mass:
    4575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSNAX-DISC1 Gene

Post-translational modifications for TSNAX-DISC1 Gene

No Post-translational modifications

Other Protein References for TSNAX-DISC1 Gene

No data available for DME Specific Peptides for TSNAX-DISC1 Gene

Domains & Families for TSNAX-DISC1 Gene

Protein Domains for TSNAX-DISC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSNAX-DISC1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TSNAX-DISC1 Gene

Function for TSNAX-DISC1 Gene

Phenotypes From GWAS Catalog for TSNAX-DISC1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSNAX-DISC1 Gene

Localization for TSNAX-DISC1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TSNAX-DISC1 Gene

Pathways & Interactions for TSNAX-DISC1 Gene

SuperPathways for TSNAX-DISC1 Gene

No Data Available

Interacting Proteins for TSNAX-DISC1 Gene

Gene Ontology (GO) - Biological Process for TSNAX-DISC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSNAX-DISC1 Gene

Drugs & Compounds for TSNAX-DISC1 Gene

No Compound Related Data Available

Transcripts for TSNAX-DISC1 Gene


(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX-DISC1 Gene

No ASD Table

Relevant External Links for TSNAX-DISC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSNAX-DISC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSNAX-DISC1 Gene

mRNA differential expression in normal tissues according to GTEx for TSNAX-DISC1 Gene

This gene is overexpressed in Testis (x6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for TSNAX-DISC1 Gene

genes like me logo Genes that share expression patterns with TSNAX-DISC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSNAX-DISC1 Gene

Orthologs for TSNAX-DISC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSNAX-DISC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSNAX 34
  • 56 (a)
(Canis familiaris)
Mammalia -- 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
(Gallus gallus)
Aves TSNAX 34
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
(Danio rerio)
Actinopterygii tsnax 34
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trax 34
  • 20 (a)
Species where no ortholog for TSNAX-DISC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSNAX-DISC1 Gene

Gene Tree for TSNAX-DISC1 (if available)
Gene Tree for TSNAX-DISC1 (if available)

Paralogs for TSNAX-DISC1 Gene

Paralogs for TSNAX-DISC1 Gene

genes like me logo Genes that share paralogs with TSNAX-DISC1: view

Variants for TSNAX-DISC1 Gene

Sequence variations from dbSNP and Humsavar for TSNAX-DISC1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs367543082 not-provided, not provided 231,626,921(+) G/A intron_variant
rs367543083 not-provided, not provided 231,694,098(+) A/T non_coding_transcript_variant
rs367543084 not-provided, not provided 231,694,230(+) G/A non_coding_transcript_variant
rs367543085 not-provided, not provided 231,694,526(+) C/T non_coding_transcript_variant
rs367543086 not-provided, not provided 231,694,599(+) G/A non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSNAX-DISC1 Gene

Variant ID Type Subtype PubMed ID
dgv153e212 CNV gain 25503493
dgv293n106 CNV deletion 24896259
dgv582n100 CNV gain 25217958
dgv849n54 CNV gain 21841781
esv1761772 CNV insertion 17803354
esv2656516 CNV deletion 23128226
esv2657352 CNV deletion 23128226
esv2661657 CNV deletion 23128226
esv2668388 CNV deletion 23128226
esv2672018 CNV deletion 23128226
esv2724872 CNV deletion 23290073
esv2724883 CNV deletion 23290073
esv2724894 CNV deletion 23290073
esv2724905 CNV deletion 23290073
esv2724917 CNV deletion 23290073
esv2759004 CNV gain 17122850
esv2762173 CNV loss 21179565
esv2763669 CNV gain 21179565
esv3308383 CNV mobile element insertion 20981092
esv3409551 CNV duplication 20981092
esv3429698 CNV duplication 20981092
esv3434648 CNV insertion 20981092
esv3446715 CNV insertion 20981092
esv3449086 CNV insertion 20981092
esv3575783 CNV gain 25503493
esv3589115 CNV loss 21293372
esv3589116 CNV gain 21293372
esv3589119 CNV loss 21293372
esv3589120 CNV loss 21293372
esv3589121 CNV loss 21293372
esv3589124 CNV loss 21293372
esv994187 CNV insertion 20482838
nsv1003284 CNV loss 25217958
nsv1011509 CNV gain 25217958
nsv1013883 CNV gain 25217958
nsv1113226 CNV deletion 24896259
nsv1113227 CNV deletion 24896259
nsv1115033 CNV deletion 24896259
nsv1119761 CNV deletion 24896259
nsv468338 CNV gain 19166990
nsv468382 CNV loss 19166990
nsv474919 CNV novel sequence insertion 20440878
nsv476204 CNV novel sequence insertion 20440878
nsv477268 CNV novel sequence insertion 20440878
nsv4821 CNV insertion 18451855
nsv4832 CNV insertion 18451855
nsv4843 CNV insertion 18451855
nsv4855 CNV insertion 18451855
nsv509646 CNV insertion 20534489
nsv516935 CNV gain 19592680
nsv528452 CNV loss 19592680
nsv549338 CNV loss 21841781
nsv827230 CNV gain 20364138
nsv8902 CNV gain 18304495
nsv952147 CNV duplication 24416366
nsv999063 CNV gain 25217958

Additional Variant Information for TSNAX-DISC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TSNAX-DISC1 Gene

Disorders for TSNAX-DISC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSNAX-DISC1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia 1
  • sczd1
  • sczd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSNAX-DISC1

genes like me logo Genes that share disorders with TSNAX-DISC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSNAX-DISC1 Gene

Publications for TSNAX-DISC1 Gene

  1. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PMID: 21659360) Wade R … Houlston RS (Haematologica 2011) 3 58
  2. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. (PMID: 21483430) Carless MA … Blangero J (Molecular psychiatry 2011) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  4. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. (PMID: 19255581) Schosser A … McGuffin P (Molecular psychiatry 2010) 3 58
  5. DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. (PMID: 19805229) Nakata K … Kleinman JE (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 58

Products for TSNAX-DISC1 Gene

Sources for TSNAX-DISC1 Gene

Loading form....