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Aliases for TSNAX-DISC1 Gene

Subcategory (RNA class) for TSNAX-DISC1 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for TSNAX-DISC1 Gene

  • TSNAX-DISC1 Readthrough (NMD Candidate) 2 3 5

External Ids for TSNAX-DISC1 Gene

Previous GeneCards Identifiers for TSNAX-DISC1 Gene

  • GC00U928277
  • GC01U902499
  • GC01P202147
  • GC01P231665

Summaries for TSNAX-DISC1 Gene

Entrez Gene Summary for TSNAX-DISC1 Gene

  • This gene represents naturally occurring read-through transcription between the neighboring TSNAX (translin-associated factor X) and DISC1 (disrupted in schizophrenia 1) genes on chromosome 1. Alternative splicing results in multiple transcript variants, all of which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. These alterations in gene processing may be associated with risk for psychiatric illness, most notably, schizophrenia. [provided by RefSeq, Nov 2010]

GeneCards Summary for TSNAX-DISC1 Gene

TSNAX-DISC1 (TSNAX-DISC1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with TSNAX-DISC1 include Schizophrenia. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is TSNAX.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSNAX-DISC1 Gene

Genomics for TSNAX-DISC1 Gene

Regulatory Elements for TSNAX-DISC1 Gene

Enhancers for TSNAX-DISC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSNAX-DISC1 on UCSC Golden Path with GeneCards custom track

Promoters for TSNAX-DISC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSNAX-DISC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSNAX-DISC1 Gene

Chromosome:
1
Start:
231,528,653 bp from pter
End:
232,041,272 bp from pter
Size:
512,620 bases
Orientation:
Plus strand

Genomic View for TSNAX-DISC1 Gene

Genes around TSNAX-DISC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSNAX-DISC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSNAX-DISC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSNAX-DISC1 Gene

Proteins for TSNAX-DISC1 Gene

  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C4P0D4
    Recommended name:
    Disrupted in schizophrenia 1 isoform 47
    Protein Accession:
    C4P0D4

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    138 amino acids
    Molecular mass:
    16111 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C4P0D6
    Recommended name:
    Disrupted in schizophrenia 1 isoform 49
    Protein Accession:
    C4P0D6

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    186 amino acids
    Molecular mass:
    21427 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C4P0D8
    Recommended name:
    Disrupted in schizophrenia 1 isoform 51
    Protein Accession:
    C4P0D8

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    188 amino acids
    Molecular mass:
    21477 Da
    Quaternary structure:
    No Data Available
  • Protein details for TSNAX-DISC1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q9NRI2
    Recommended name:
    Disrupted in schizophrenia 1 isoform 52
    Protein Accession:
    Q9NRI2

    Protein attributes for TSNAX-DISC1 Gene

    Size:
    40 amino acids
    Molecular mass:
    4575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSNAX-DISC1 Gene

Proteomics data for TSNAX-DISC1 Gene at MOPED

Post-translational modifications for TSNAX-DISC1 Gene

No Post-translational modifications

Other Protein References for TSNAX-DISC1 Gene

No data available for DME Specific Peptides for TSNAX-DISC1 Gene

Domains & Families for TSNAX-DISC1 Gene

Protein Domains for TSNAX-DISC1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSNAX-DISC1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TSNAX-DISC1 Gene

Function for TSNAX-DISC1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSNAX-DISC1 Gene

Localization for TSNAX-DISC1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TSNAX-DISC1 Gene

Pathways & Interactions for TSNAX-DISC1 Gene

SuperPathways for TSNAX-DISC1 Gene

No Data Available

Interacting Proteins for TSNAX-DISC1 Gene

Gene Ontology (GO) - Biological Process for TSNAX-DISC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TSNAX-DISC1 Gene

Drugs & Compounds for TSNAX-DISC1 Gene

No Compound Related Data Available

Transcripts for TSNAX-DISC1 Gene

mRNA/cDNA for TSNAX-DISC1 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX-DISC1 Gene

No ASD Table

Relevant External Links for TSNAX-DISC1 Gene

GeneLoc Exon Structure for
TSNAX-DISC1
ECgene alternative splicing isoforms for
TSNAX-DISC1

Expression for TSNAX-DISC1 Gene

mRNA expression in normal human tissues for TSNAX-DISC1 Gene

mRNA differential expression in normal tissues according to GTEx for TSNAX-DISC1 Gene

This gene is overexpressed in Testis (x6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from for TSNAX-DISC1 Gene



genes like me logo Genes that share expression patterns with TSNAX-DISC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSNAX-DISC1 Gene

Orthologs for TSNAX-DISC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSNAX-DISC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSNAX 36
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves TSNAX 36
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tsnax 36
  • 37 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Trax 36
  • 20 (a)
OneToMany
Species with no ortholog for TSNAX-DISC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSNAX-DISC1 Gene

ENSEMBL:
Gene Tree for TSNAX-DISC1 (if available)
TreeFam:
Gene Tree for TSNAX-DISC1 (if available)

Paralogs for TSNAX-DISC1 Gene

Paralogs for TSNAX-DISC1 Gene

genes like me logo Genes that share paralogs with TSNAX-DISC1: view

Variants for TSNAX-DISC1 Gene

Sequence variations from dbSNP and Humsavar for TSNAX-DISC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1025526 -- 231,614,895(-) CTGAA(A/G)TGTAT intron-variant
rs1025527 -- 231,614,099(-) GCAGC(C/T)GCCTA intron-variant
rs1030710 -- 231,620,523(-) aagag(A/G)tgtag intron-variant
rs1030711 -- 231,619,715(-) CACTC(A/T)CCATT intron-variant
rs1612154 -- 231,589,122(+) TGGGA(A/G)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSNAX-DISC1 Gene

Variant ID Type Subtype PubMed ID
nsv873293 CNV Gain 21882294
dgv544n71 CNV Loss 21882294
dgv187e1 CNV Complex 17122850
nsv516935 CNV Gain 19592680
esv2724872 CNV Deletion 23290073
nsv873296 CNV Gain 21882294
nsv8902 CNV Gain 18304495
nsv873297 CNV Loss 21882294
nsv468338 CNV Gain 19166990
nsv4821 CNV Insertion 18451855
dgv188e1 CNV Complex 17122850
esv2656516 CNV Deletion 23128226
nsv4832 CNV Insertion 18451855
dgv545n71 CNV Loss 21882294
nsv873300 CNV Loss 21882294
esv2724883 CNV Deletion 23290073
esv1761772 CNV Insertion 17803354
esv2724894 CNV Deletion 23290073
esv2724905 CNV Deletion 23290073
esv2672018 CNV Deletion 23128226
esv2724917 CNV Deletion 23290073
nsv509646 CNV Insertion 20534489
nsv4843 CNV Insertion 18451855
esv272656 CNV Insertion 20981092
esv271157 CNV Insertion 20981092
esv994187 CNV Insertion 20482838
esv2657352 CNV Deletion 23128226
esv2668388 CNV Deletion 23128226
nsv4855 CNV Insertion 18451855
esv2661657 CNV Deletion 23128226
nsv468382 CNV Loss 19166990
nsv873301 CNV Loss 21882294
nsv827230 CNV Gain 20364138
nsv528452 CNV Loss 19592680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for TSNAX-DISC1 Gene

Disorders for TSNAX-DISC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSNAX-DISC1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSNAX-DISC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSNAX-DISC1
genes like me logo Genes that share disorders with TSNAX-DISC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSNAX-DISC1 Gene

Publications for TSNAX-DISC1 Gene

  1. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. (PMID: 21483430) Carless M.A. … Blangero J. (Mol. Psychiatry 2011) 3 67
  2. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PMID: 21659360) Wade R. … Houlston R.S. (Haematologica 2011) 3
  3. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. (PMID: 19255581) Schosser A. … McGuffin P. (Mol. Psychiatry 2010) 3
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  5. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. (PMID: 19118814) Beecham G.W. … Pericak-Vance M.A. (Am. J. Hum. Genet. 2009) 3

Products for TSNAX-DISC1 Gene

Sources for TSNAX-DISC1 Gene

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