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Aliases for TSNAX Gene

Aliases for TSNAX Gene

  • Translin Associated Factor X 2 3 5
  • TRAX 3 4
  • Translin-Associated Protein X 3
  • Translin-Associated Factor X 4
  • Translin-Like Protein 3

External Ids for TSNAX Gene

Previous GeneCards Identifiers for TSNAX Gene

  • GC01P230110
  • GC01P227404
  • GC01P228137
  • GC01P228699
  • GC01P227971
  • GC01P229730
  • GC01P231664
  • GC01P202148

Summaries for TSNAX Gene

Entrez Gene Summary for TSNAX Gene

  • This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSNAX Gene

TSNAX (Translin Associated Factor X) is a Protein Coding gene. Diseases associated with TSNAX include Schizophrenia. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is TSNAX-DISC1.

UniProtKB/Swiss-Prot for TSNAX Gene

  • Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.

Gene Wiki entry for TSNAX Gene

Additional gene information for TSNAX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSNAX Gene

Genomics for TSNAX Gene

GeneHancer (GH) Regulatory Elements for TSNAX Gene

Promoters and enhancers for TSNAX Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I231527 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 557 +0.4 396 3.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TSNAX ENSG00000233461 TSNAX-DISC1 C1orf131 COG2 DISC1 GNPAT EXOC8 SPRTN GC01P231515
GH01I231599 Enhancer 0.8 ENCODE 10.8 +72.3 72346 2.6 PKNOX1 ZNF529 MZF1 FEZF1 ZNF335 ZNF213 RCOR1 ZNF680 ZNF362 OVOL3 DISC1 ENSG00000233461 TSNAX EGLN1 LINC00582 GC01P231591 GC01P231590 TSNAX-DISC1 GC01P231515
GH01I231724 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.6 +196.5 196547 0.8 PKNOX1 ATF1 RB1 SIN3A BMI1 ZBTB40 RAD21 ELK1 ZNF143 ATF7 DISC1 TSNAX GC01P231693 ENSG00000274121 TSNAX-DISC1
GH01I231494 Enhancer 0.5 FANTOM5 3.1 -34.0 -34001 0.2 MITF FOXA2 ZNF512 USF2 TSNAX DISC1 GC01M231493 SNRPD2P2
GH01I231585 Enhancer 0.4 FANTOM5 2.7 +56.5 56506 0.3 ZNF416 ATF2 LINC00582 EGLN1 DISC1 TSNAX GC01P231590 GC01P231591 TSNAX-DISC1 GC01P231515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSNAX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSNAX gene promoter:

Genomic Locations for TSNAX Gene

Genomic Locations for TSNAX Gene
chr1:231,528,653-231,566,524
(GRCh38/hg38)
Size:
37,872 bases
Orientation:
Plus strand
chr1:231,664,399-231,702,270
(GRCh37/hg19)

Genomic View for TSNAX Gene

Genes around TSNAX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSNAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSNAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSNAX Gene

Proteins for TSNAX Gene

  • Protein details for TSNAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99598-TSNAX_HUMAN
    Recommended name:
    Translin-associated protein X
    Protein Accession:
    Q99598
    Secondary Accessions:
    • B1APC6

    Protein attributes for TSNAX Gene

    Size:
    290 amino acids
    Molecular mass:
    33112 Da
    Quaternary structure:
    • Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.

    Three dimensional structures from OCA and Proteopedia for TSNAX Gene

neXtProt entry for TSNAX Gene

Post-translational modifications for TSNAX Gene

  • Sumoylated with SUMO1.
  • Ubiquitination at posLast=150150, isoforms=173, posLast=241241, isoforms=261, and posLast=269269

Other Protein References for TSNAX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSNAX Gene

Domains & Families for TSNAX Gene

Gene Families for TSNAX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSNAX Gene

Graphical View of Domain Structure for InterPro Entry

Q99598

UniProtKB/Swiss-Prot:

TSNAX_HUMAN :
  • Belongs to the translin family.
Family:
  • Belongs to the translin family.
genes like me logo Genes that share domains with TSNAX: view

Function for TSNAX Gene

Molecular function for TSNAX Gene

UniProtKB/Swiss-Prot Function:
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for TSNAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9013868
GO:0003723 RNA binding IDA,HDA 22681889
GO:0005515 protein binding IPI 16189514
GO:0008565 protein transporter activity TAS 9013868
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TSNAX: view

Phenotypes for TSNAX Gene

GenomeRNAi human phenotypes for TSNAX:
genes like me logo Genes that share phenotypes with TSNAX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSNAX Gene

Localization for TSNAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSNAX Gene

Cytoplasm, perinuclear region. Golgi apparatus. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSNAX gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 3
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSNAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSNAX: view

Pathways & Interactions for TSNAX Gene

genes like me logo Genes that share pathways with TSNAX: view

Pathways by source for TSNAX Gene

Gene Ontology (GO) - Biological Process for TSNAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0015031 protein transport IEA --
GO:0030154 cell differentiation IEA --
GO:0030422 production of siRNA involved in RNA interference TAS --
genes like me logo Genes that share ontologies with TSNAX: view

No data available for SIGNOR curated interactions for TSNAX Gene

Drugs & Compounds for TSNAX Gene

No Compound Related Data Available

Transcripts for TSNAX Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2:
SP3: - - -
SP4: -

Relevant External Links for TSNAX Gene

GeneLoc Exon Structure for
TSNAX
ECgene alternative splicing isoforms for
TSNAX

Expression for TSNAX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSNAX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSNAX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0), Lymph node (8.0), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSNAX Gene



Protein tissue co-expression partners for TSNAX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSNAX Gene:

TSNAX

Evidence on tissue expression from TISSUES for TSNAX Gene

  • Nervous system(4.4)
  • Muscle(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with TSNAX: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSNAX Gene

Orthologs for TSNAX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSNAX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSNAX 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia TSNAX 33 34
  • 94.37 (n)
cow
(Bos Taurus)
Mammalia TSNAX 33 34
  • 92.99 (n)
mouse
(Mus musculus)
Mammalia Tsnax 33 16 34
  • 85.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tsnax 33
  • 82.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves TSNAX 33 34
  • 74.95 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tsnax 33
  • 67.94 (n)
Str.15324 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64311 33
zebrafish
(Danio rerio)
Actinopterygii tsnax 33 34
  • 62.75 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8661 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004585 33
  • 48.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta Trax 33 34
  • 45.04 (n)
CG5063 35
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G03780 33
  • 51.25 (n)
rice
(Oryza sativa)
Liliopsida Os01g0265900 33
  • 54.93 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06059 33
  • 44.53 (n)
Species where no ortholog for TSNAX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSNAX Gene

ENSEMBL:
Gene Tree for TSNAX (if available)
TreeFam:
Gene Tree for TSNAX (if available)

Paralogs for TSNAX Gene

Paralogs for TSNAX Gene

(3) SIMAP similar genes for TSNAX Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TSNAX Gene

genes like me logo Genes that share paralogs with TSNAX: view

Variants for TSNAX Gene

Sequence variations from dbSNP and Humsavar for TSNAX Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000025103 -- 231,531,179(+) G/C intron_variant
rs1000110509 -- 231,552,485(+) A/G intron_variant
rs1000226260 -- 231,553,860(+) A/G intron_variant
rs1000263996 -- 231,534,395(+) A/G intron_variant
rs1000278509 -- 231,553,699(+) /C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSNAX Gene

Variant ID Type Subtype PubMed ID
esv2759004 CNV gain 17122850
esv2763669 CNV gain 21179565
esv3589115 CNV loss 21293372
nsv516935 CNV gain 19592680

Variation tolerance for TSNAX Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSNAX Gene

Human Gene Mutation Database (HGMD)
TSNAX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSNAX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSNAX Gene

Disorders for TSNAX Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSNAX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search TSNAX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TSNAX

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TSNAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSNAX Gene

Publications for TSNAX Gene

  1. Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. (PMID: 19760522) Okuda A … Iwata N (Neuromolecular medicine 2010) 3 22 44 58
  2. Co-expressed recombinant human Translin-Trax complex binds DNA. (PMID: 15919079) Gupta GD … Rao BJ (FEBS letters 2005) 3 4 22 58
  3. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. (PMID: 16275808) Cannon TD … Peltonen L (Archives of general psychiatry 2005) 3 22 44 58
  4. Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX. (PMID: 9013868) Aoki K … Kasai M (FEBS letters 1997) 2 3 4 58
  5. Structure of C3PO and mechanism of human RISC activation. (PMID: 21552258) Ye X … Zhang H (Nature structural & molecular biology 2011) 3 4 58

Products for TSNAX Gene

Sources for TSNAX Gene

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