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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSNAX Gene

protein-coding   GIFtS: 53
GCID: GC01P231664

Translin-Associated Factor X

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translin-Associated Factor X1 2 3
TRAX2 3 5
Translin-Associated Protein X2
Translin-Like Protein2

External Ids:    HGNC: 123801   Entrez Gene: 72572   Ensembl: ENSG000001169187   OMIM: 6029645   UniProtKB: Q995983   

Export aliases for TSNAX gene to outside databases

Previous GC identifers: GC01P230110 GC01P227404 GC01P228137 GC01P228699 GC01P227971 GC01P229730 GC01P202148


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSNAX Gene:
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus
sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear
targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TSNAX Gene: 
TSNAX (translin-associated factor X) is a protein-coding gene. Diseases associated with TSNAX include major depressive disorder, and schizophrenia. GO annotations related to this gene include protein transporter activity and sequence-specific DNA binding. An important paralog of this gene is ENSG00000270106.

UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598
Function: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing
complex (RISC). Possible role in spermatogenesis

Gene Wiki entry for TSNAX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSNAX gene promoter:
         COUP-TF1   RREB-1   FOXO3   COUP   HNF-4alpha2   FOXO3b   HNF-4alpha1   POU2F2C   COUP-TF   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSNAX promoter sequence
   Search SABiosciences Chromatin IP Primers for TSNAX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSNAX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.1   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

TSNAX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSNAX gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P231664:  view genomic region     (about GC identifiers)

Start:
231,664,399 bp from pter      End:
231,702,270 bp from pter
Size:
37,872 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598 (See protein sequence)
Recommended Name: Translin-associated protein X  
Size: 290 amino acids; 33112 Da
Subunit: Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and
AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a
mutually exclusive manner
Subcellular location: Cytoplasm, perinuclear region. Golgi apparatus (By similarity). Nucleus. Note=Accumulate in
the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence
of TSN
2 PDB 3D structures from and Proteopedia for TSNAX:
3PJA (3D)        3QB5 (3D)    
Secondary accessions: B1APC6

Explore the universe of human proteins at neXtProt for TSNAX: NX_Q99598

Explore proteomics data for TSNAX at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated with SUMO1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99598

  • TSNAX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSNAX Protein Expression
    REFSEQ proteins: NP_005990.1  
    ENSEMBL proteins: 
     ENSP00000355599   ENSP00000397537  

    Human Recombinant Protein Products for TSNAX: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TSNAX
    Cloud-Clone Corp. Proteins for TSNAX 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    TSNAX for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016069 Translin_C
     IPR002848 Translin
     IPR016068 Translin_N

    Graphical View of Domain Structure for InterPro Entry Q99598

    ProtoNet protein and cluster: Q99598

    1 Blocks protein domain: IPB002848 Translin

    UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598
    Similarity: Belongs to the translin family


    TSNAX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSNAX_HUMAN, Q99598
    Function: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing
    complex (RISC). Possible role in spermatogenesis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9013868
    GO:0008565protein transporter activity TAS9013868
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    TSNAX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSNAX:
     High actin ratio cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTSNAX 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSNAX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/26 Interacting proteins for TSNAX (Q995982, 3 ENSP000003555994) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSNQ156312, 3, ENSP000003743324MINT-60097 I2D: score=8 STRING: ENSP00000374332
    SUN1O949013, ENSP000003840154I2D: score=5 STRING: ENSP00000384015
    AKAP9Q999963, ENSP000003485734I2D: score=4 STRING: ENSP00000348573
    C1DQ139013, ENSP000003481074I2D: score=4 STRING: ENSP00000348107
    GADD45GO952573, ENSP000002525064I2D: score=4 STRING: ENSP00000252506
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0015031protein transport TAS9013868
    GO:0030154cell differentiation IEA--

    TSNAX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSNAX

    Search CenterWatch for drugs/clinical trials and news about TSNAX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSNAX gene: 
    NM_005999.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366639(uc001huw.3) ENST00000413309 ENST00000602825 ENST00000476913
    ENST00000475168
    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate TSNAX (see all 21):
    hsa-miR-137 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-550a* hsa-miR-373* hsa-miR-9 hsa-miR-1323 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidTSNAX 3' UTR sequence
    Inhib. RNA
    Products:
         
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    24/148 AceView cDNA sequences (see all 148):

    BQ434656 AU121112 BQ937639 BP383183 BP350255 BX537610 BQ422881 NM_005999 
    BX279887 CB164660 AA706513 AU280156 AV727466 AA862725 BI915250 AU117679 
    BM014709 BU146562 BC011797 BM558645 BQ217524 AW023524 X95073 AU133231 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
    SP1:                                -                                       
    SP2:                                                                        
    SP3:                    -     -     -                                       
    SP4:                                -                                       


    ECgene alternative splicing isoforms for TSNAX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSNAX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSNAX Expression
    About this image


    See TSNAX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSNAX
        SABiosciences Custom PCR Arrays for TSNAX
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TSNAX gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsnax1 , 5 translin-associated factor X1, 5 85.63(n)1
    90.69(a)1
      8 (73.10 cM)5
    534241  NM_016909.21  NP_058605.11 
     1250129975 
    chicken
    (Gallus gallus)
    Aves TSNAX1 translin-associated factor X 74.95(n)
    76.36(a)
      421526  NM_001006403.1  NP_001006403.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSNAX6
    Uncharacterized protein
    80(a)
    1 → many
    1(221683131-221702940)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643112 hypothetical protein MGC64311 76.26(n)    BC041547.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsnax1 translin-associated factor X 62.63(n)
    65.48(a)
      556657  NM_001030104.1  NP_001025275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50633
    Trax1
    Translin associated factor X1 35(a)3
    45.17(n)1
    39.31(a)1
      88F13
    418711  NM_169650.21  NP_732021.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G037801 translin-like protein 50.81(n)
    38.22(a)
      814905  NM_126425.3  NP_178473.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g02659001 hypothetical protein 53.17(n)
    42.06(a)
      4324369  NM_001049208.2  NP_001042673.2 


    ENSEMBL Gene Tree for TSNAX (if available)
    TreeFam Gene Tree for TSNAX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSNAX gene
    ENSG000002701062  
    3 SIMAP similar genes for TSNAX using alignment to 2 protein entries:     TSNAX_HUMAN (see all proteins):
    DKFZp686G1650    TRAX    DISC1

    TSNAX for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TSNAX
    PGOHUM00000247742


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TSNAX:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv544n71CNV Loss21882294
    nsv873293CNV Gain21882294
    nsv516935CNV Gain19592680
    dgv187e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602964    OMIM disorders: --

    3 diseases for TSNAX:    About MalaCards
    major depressive disorder    schizophrenia    bipolar disorder

    2 diseases from the University of Copenhagen DISEASES database for TSNAX:
    Schizophrenia     Major depressive disorder

    TSNAX for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TSNAX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 37.9 9 16275808 (3), 10945471 (1), 16103888 (1)

    Genetic Association Database (GAD): TSNAX
    Human Genome Epidemiology (HuGE) Navigator: TSNAX (8 documents)

    Export disorders for TSNAX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSNAX gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with TSNAX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a cDNA encoding a translin-like protein, TRAX. (PubMed id 9013868)1, 2, 3 Aoki K.... Kasai M. (1997)
    2. Translin-associated factor X gene (TSNAX) may be asso ciated with female major depressive disorder in the Japanese population. (PubMed id 19760522)1, 4, 9 Okuda A....Iwata N. (2010)
    3. Co-expressed recombinant human Translin-Trax complex binds DNA. (PubMed id 15919079)1, 2, 9 Gupta G.D....Rao B.J. (2005)
    4. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. (PubMed id 16275808)1, 4, 9 Cannon T.D....Peltonen L. (2005)
    5. Structure of C3PO and mechanism of human RISC activat ion. (PubMed id 21552258)1, 2 Ye X....Zhang H. (2011)
    6. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (2010)
    7. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    8. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. (PubMed id 19255581)1, 4 Schosser A....McGuffin P. (2009)
    9. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7257 HGNC: 12380 AceView: TSNAX Ensembl:ENSG00000116918 euGenes: HUgn7257
    ECgene: TSNAX H-InvDB: TSNAX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSNAX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSNAX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSNAX gene:
    Search GeneIP for patents involving TSNAX

    GeneCards and IP:
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