Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TSNAX Gene

protein-coding   GIFtS: 55
GCID: GC01P231664

Translin-Associated Factor X

  See TSNAX-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Translin-Associated Factor X1 2 3
TRAX2 3 5
Translin-Associated Protein X2
Translin-Like Protein2

External Ids:    HGNC: 123801   Entrez Gene: 72572   Ensembl: ENSG000001169187   OMIM: 6029645   UniProtKB: Q995983   

Export aliases for TSNAX gene to outside databases

Previous GC identifers: GC01P230110 GC01P227404 GC01P228137 GC01P228699 GC01P227971 GC01P229730 GC01P202148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TSNAX Gene:
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus
sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear
targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TSNAX Gene:
TSNAX (translin-associated factor X) is a protein-coding gene. Diseases associated with TSNAX include schizophrenia. GO annotations related to this gene include protein transporter activity and sequence-specific DNA binding. An important paralog of this gene is TSNAX-DISC1.

UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598
Function: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing
complex (RISC). Possible role in spermatogenesis

Gene Wiki entry for TSNAX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the TSNAX gene promoter:
         COUP-TF1   RREB-1   FOXO3   COUP   HNF-4alpha2   FOXO3b   HNF-4alpha1   POU2F2C   COUP-TF   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSNAX promoter sequence
   Search Chromatin IP Primers for TSNAX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSNAX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.1   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

TSNAX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSNAX gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P231664:  view genomic region     (about GC identifiers)

Start:
231,664,399 bp from pter      End:
231,702,270 bp from pter
Size:
37,872 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598 (See protein sequence)
Recommended Name: Translin-associated protein X  
Size: 290 amino acids; 33112 Da
Subunit: Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and
AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a
mutually exclusive manner
2 PDB 3D structures from and Proteopedia for TSNAX:
3PJA (3D)        3QB5 (3D)    
Secondary accessions: B1APC6

Explore the universe of human proteins at neXtProt for TSNAX: NX_Q99598

Explore proteomics data for TSNAX at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO11
  • Ubiquitination2 at Lys150, Lys173, Lys241, Lys261, Lys269
  • Modification sites at PhosphoSitePlus

  • See TSNAX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005990.1  
    ENSEMBL proteins: 
     ENSP00000355599   ENSP00000397537  

    TSNAX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TSNAX
    OriGene Protein Over-expression Lysate for TSNAX
    OriGene MassSpec for TSNAX
    OriGene Custom Protein Services for TSNAX
    GenScript Custom Purified and Recombinant Proteins Services for TSNAX
    Novus Biologicals TSNAX Proteins
    Novus Biologicals TSNAX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TSNAX
    Cloud-Clone Corp. Proteins for TSNAX

     
    Search eBioscience for Proteins for TSNAX 

    TSNAX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSNAX
    Novus Biologicals TSNAX Antibodies
    Abcam antibodies for TSNAX
    Cloud-Clone Corp. Antibodies for TSNAX
    Search ThermoFisher Antibodies for TSNAX
    LSBio Antibodies in human, mouse, rat for TSNAX

    TSNAX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSNAX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSNAX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSNAX
    Cloud-Clone Corp. CLIAs for TSNAX
    Search eBioscience for ELISAs for TSNAX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR016069 Translin_C
     IPR002848 Translin
     IPR016068 Translin_N

    Graphical View of Domain Structure for InterPro Entry Q99598

    ProtoNet protein and cluster: Q99598

    1 Blocks protein domain: IPB002848 Translin

    UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598
    Similarity: Belongs to the translin family


    Find genes that share domains with TSNAX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSNAX_HUMAN, Q99598
    Function: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing
    complex (RISC). Possible role in spermatogenesis

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9013868
    GO:0005515protein binding ----
    GO:0008565protein transporter activity TAS9013868
    GO:0031687A2A adenosine receptor binding IEA--
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with TSNAX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TSNAX:
     High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSNAX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSNAX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSNAX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSNAX

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSNAX:
    hsa-mir-21-5p (MIRT030855)

    Block miRNA regulation of human, mouse, rat TSNAX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSNAX (see all 21):
    hsa-miR-137 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-550a* hsa-miR-373* hsa-miR-9 hsa-miR-1323 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidTSNAX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSNAX
    Predesigned siRNA for gene silencing in human, mouse, rat TSNAX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSNAX

    Clone
    Products:
         
    OriGene clones in human, mouse for TSNAX (see all 6)
    OriGene ORF clones in mouse, rat for TSNAX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSNAX (NM_005999)
    Sino Biological Human cDNA Clone for TSNAX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSNAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSNAX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSNAX
    Browse ESI BIO Cell Lines and PureStem Progenitors for TSNAX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSNAX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TSNAX_HUMAN, Q99598: Cytoplasm, perinuclear region. Golgi apparatus (By similarity). Nucleus. Note=Accumulate in
    the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence
    of TSN
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with TSNAX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSNAX
    Interactions:

        GeneGlobe Interaction Network for TSNAX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for TSNAX (Q995982, 3 ENSP000003555994) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSNQ156312, 3, ENSP000003743324MINT-60097 I2D: score=8 STRING: ENSP00000374332
    SUN1O949013, ENSP000003840154I2D: score=5 STRING: ENSP00000384015
    AKAP9Q999963, ENSP000003485734I2D: score=4 STRING: ENSP00000348573
    C1DQ139013, ENSP000003481074I2D: score=4 STRING: ENSP00000348107
    GADD45GO952573, ENSP000002525064I2D: score=4 STRING: ENSP00000252506
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0015031protein transport TAS9013868
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with TSNAX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSNAX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TSNAX gene: 
    NM_005999.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366639(uc001huw.3) ENST00000413309 ENST00000602825 ENST00000476913
    ENST00000475168
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSNAX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSNAX (see all 21):
    hsa-miR-137 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-550a* hsa-miR-373* hsa-miR-9 hsa-miR-1323 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidTSNAX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSNAX
    Predesigned siRNA for gene silencing in human, mouse, rat TSNAX
    Clone
    Products:
         
    OriGene clones in human, mouse for TSNAX (see all 6)
    OriGene ORF clones in mouse, rat for TSNAX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSNAX (NM_005999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSNAX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSNAX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSNAX
    OriGene qSTAR qPCR primer pairs in human, mouse for TSNAX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSNAX
      QuantiTect SYBR Green Assays in human, mouse, rat TSNAX
      QuantiFast Probe-based Assays in human, mouse, rat TSNAX

    Selected AceView cDNA sequences (see all 148):

    CB164660 AA862725 BC011797 BM558645 NM_005999 BX279887 BM014709 BU146562 
    BI915250 AA706513 AU280156 AU117679 AV727466 AA599718 BP375144 AU121112 
    BX537610 BQ422881 BM783006 BP344627 BU616465 BQ217524 BP350255 X95073 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
    SP1:                                -                                       
    SP2:                                                                        
    SP3:                    -     -     -                                       
    SP4:                                -                                       


    ECgene alternative splicing isoforms for TSNAX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TSNAX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSNAX Expression
    About this image


    TSNAX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TSNAX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSNAX Protein Expression
        Custom PCR Arrays for TSNAX
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TSNAX
    OriGene qSTAR qPCR primer pairs in human, mouse for TSNAX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSNAX
    QuantiTect SYBR Green Assays in human, mouse, rat TSNAX
    QuantiFast Probe-based Assays in human, mouse, rat TSNAX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSNAX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TSNAX gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsnax1 , 5 translin-associated factor X1, 5 85.63(n)1
    90.69(a)1
      8 (73.10 cM)5
    534241  NM_016909.21  NP_058605.11 
     1250129975 
    chicken
    (Gallus gallus)
    Aves TSNAX1 translin-associated factor X 74.95(n)
    76.36(a)
      421526  NM_001006403.1  NP_001006403.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    81(a)
    1 → many
    1(221683131-221702940)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643112 hypothetical protein MGC64311 76.26(n)    BC041547.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsnax1 translin-associated factor X 62.75(n)
    65.12(a)
      556657  NM_001030104.1  NP_001025275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50633
    Trax1
    Translin associated factor X1 35(a)3
    45.04(n)1
    39.31(a)1
      88F13
    418711  NM_169650.31  NP_732021.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G037801 AT2G03780 51.25(n)
    38.77(a)
      814905  NM_126425.3  NP_178473.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g02659001 Os01g0265900 54.93(n)
    44.8(a)
      4324369  NM_001049208.2  NP_001042673.2 


    ENSEMBL Gene Tree for TSNAX (if available)
    TreeFam Gene Tree for TSNAX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TSNAX gene
    TSNAX-DISC12  
    3 SIMAP similar genes for TSNAX using alignment to 2 protein entries:     TSNAX_HUMAN (see all proteins):
    DKFZp686G1650    TRAX    DISC1

    Find genes that share paralogs with TSNAX           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TSNAX
    PGOHUM00000247742


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TSNAX:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv544n71CNV Loss21882294
    nsv873293CNV Gain21882294
    nsv516935CNV Gain19592680
    dgv187e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSNAX
    DNA2.0 Custom Variant and Variant Library Synthesis for TSNAX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602964    OMIM disorders: --

    1 disease for TSNAX:    
    About MalaCards
    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for TSNAX:
    Schizophrenia     Major depressive disorder

    Find genes that share disorders with TSNAX           About GenesLikeMe

    1 Novoseek inferred disease relationship for TSNAX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 37.9 9 16275808 (3), 10945471 (1), 16103888 (1)

    Genetic Association Database (GAD): TSNAX
    Human Genome Epidemiology (HuGE) Navigator: TSNAX (8 documents)

    Export disorders for TSNAX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TSNAX gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with TSNAX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a cDNA encoding a translin-like protein, TRAX. (PubMed id 9013868)1, 2, 3 Aoki K.... Kasai M. (FEBS Lett. 1997)
    2. Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. (PubMed id 19760522)1, 4, 9 Okuda A....Iwata N. (Neuromolecular Med. 2010)
    3. Co-expressed recombinant human Translin-Trax complex binds DNA. (PubMed id 15919079)1, 2, 9 Gupta G.D.... Rao B.J. (FEBS Lett. 2005)
    4. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. (PubMed id 16275808)1, 4, 9 Cannon T.D....Peltonen L. (Arch. Gen. Psychiatry 2005)
    5. Structure of C3PO and mechanism of human RISC activation. (PubMed id 21552258)1, 2 Ye X....Zhang H. (Nat. Struct. Mol. Biol. 2011)
    6. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (Biol. Psychiatry 2010)
    7. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. (PubMed id 19255581)1, 4 Schosser A....McGuffin P. (Mol. Psychiatry 2010)
    8. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    9. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7257 HGNC: 12380 AceView: TSNAX Ensembl:ENSG00000116918 euGenes: HUgn7257
    ECgene: TSNAX H-InvDB: TSNAX

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TSNAX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSNAX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TSNAX gene:
    Search GeneIP for patents involving TSNAX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSNAX  
     OriGene qPCR primer pairs and template standards for TSNAX   OriGene Protein Over-expression Lysate for TSNAX  
     OriGene MassSpec something-or-other for TSNAX   OriGene clones in human, mouse for TSNAX  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSNAX   OriGene Purified Protein for TSNAX  
     OriGene ORF clones in mouse, rat for TSNAX   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSNAX   OriGene Custom Protein Services for TSNAX  

     
     
     Block miRNA regulation of human, mouse, rat TSNAX using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TSNAX
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSNAX Predesigned siRNA for gene silencing in human, mouse, rat TSNAX
     QuantiFast Probe-based Assays in human, mouse, rat TSNAX QuantiTect SYBR Green Assays in human, mouse, rat TSNAX
     Custom PCR Arrays for TSNAX Search Chromatin IP Primers for TSNAX
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSNAX  GeneGlobe Interaction Network for TSNAX
     Regulatory tfbs in TSNAX promoter
     GenScript Custom Purified and Recombinant Proteins Services for TSNAX GenScript cDNA clones with any tag delivered in your preferred vector for TSNAX
     GenScript Custom Assay Services for TSNAX GenScript Custom overexpressing Cell Line Services for TSNAX
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TSNAX
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TSNAX
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TSNAX antibodies
     TSNAX proteins
     TSNAX lysates
     Antibodies for TSNAX
     See all of Abcam's Antibodies, Kits and Proteins for TSNAX
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TSNAX
     Proteins for TSNAX
     Antibodies for TSNAX
     ELISAs for TSNAX
     CLIAs for TSNAX



     Browse ESI BIO Cell Lines and PureStem Progenitors for TSNAX
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSNAX
     SwitchGear 3'UTR luciferase reporter plasmids for TSNAX
     SwitchGear Promoter luciferase reporter plasmids for TSNAX
     Search ThermoFisher Antibodies for TSNAX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSNAX
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSNAX
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSNAX
     LSBio Antibodies in human, mouse, rat for TSNAX
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TSNAX
      Search eBioscience for proteins for TSNAX
      Search eBioscience for elisas for TSNAX
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSNAX gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4