TSNAX Gene
protein-coding GIFtS: 52
GCID: GC01P231664
|
|
translin-associated factor X
| |
Aliases
for TSNAX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translin-Associated Factor X1 2 3 | | TRAX1 2 3 5 | | Translin-Associated Protein X2 | | Translin-Like Protein2 |
Export aliases for TSNAX gene to outside databasesPrevious GC identifers: GC01P230110 GC01P227404 GC01P228137 GC01P228699 GC01P227971 GC01P229730 GC01P202148 |
Summaries
for TSNAX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSNAX:
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensussequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nucleartargeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598Function: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencingcomplex (RISC). Possible role in spermatogenesis
Gene Wiki entry for TSNAX
|
Genomic Views
for TSNAX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSNAX gene promoter:
COUP-TF1 RREB-1 FOXO3 COUP HNF-4alpha2 FOXO3b HNF-4alpha1 POU2F2C COUP-TF FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSNAX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSNAX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.1 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q42.2TSNAX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P231664: view genomic region
(about GC identifiers)
Start:
|
231,664,287 bp from pter |
End:
|
231,702,270 bp from pter |
Size:
|
37,984 bases |
Orientation:
|
plus strand |
|
Proteins
for TSNAX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598 (See
protein sequence)Recommended Name: Translin-associated protein X Size: 290 amino acids; 33112 Da
Subunit: Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9.Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutuallyexclusive manner
Subcellular location: Cytoplasm, perinuclear region. Golgi apparatus (By similarity). Nucleus. Note=Accumulate in theGolgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN
2 PDB 3D structures from  and Proteopedia  for TSNAX:3PJA (3D)
3QB5 (3D)
Secondary accessions: B1APC6Explore the universe of human proteins at neXtProt for TSNAX: NX_Q99598
Post-translational modifications:
Sumoylated with SUMO11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99598
TSNAX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005990.1
ENSEMBL proteins: ENSP00000355599 ENSP00000397537
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TSNAX for ontologies About GeneDecksing
TSNAX Antibody Products:
Assay Products for TSNAX: |
Protein
Domains /
Families
for TSNAX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSNAX for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99598ProtoNet protein and cluster: Q99598 1 Blocks protein family: IPB002848 Translin
UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598Similarity: Belongs to the translin family |
Function
for TSNAX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSNAX_HUMAN, Q99598Function: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencingcomplex (RISC). Possible role in spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSNAX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSNAX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSNAX (NM_005999) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSNAX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSNAX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSNAX |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TSNAX for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TSNAX:
|
Pathways & Interactions
for TSNAX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSNAX
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/26 Interacting proteins for TSNAX (Q995982, 3 ENSP000003555994) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TSNAX for ontologies About GeneDecksing
|
Drugs & Compounds
for TSNAX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSNAX
Search CenterWatch for drugs/clinical trials and news about TSNAX
|
Transcripts
for TSNAX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSNAX gene: NM_005999.2 4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366639(uc001huw.3) ENST00000413309 ENST00000476913 ENST00000475168
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSNAX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSNAX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSNAX (NM_005999) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSNAX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSNAX |
24/148 AceView cDNA sequences (see all 148): BX279887 NM_005999 AU133231 AA599718 BM991131 BQ937639 CD300408 BP350255 AW023524 BQ217524 BU616465 X95073 BP383183 BU146562 BC011797 BM558645 BI915250 AA862725 AU280156 AV727466 CB164660 AA706513 AU117679 BM014709
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSNAX
|
Expression
for TSNAX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSNAX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSNAX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSNAX
SABiosciences Custom PCR Arrays for TSNAX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSNAX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSNAX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSNAX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSNAX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSNAX |
Orthologs
for TSNAX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSNAX gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for TSNAX (if available)
TreeFam Gene Tree for TSNAX (if available) |
Paralogs
for TSNAX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSNAX gene
3 SIMAP similar genes for TSNAX using alignment to 2 protein entries: TSNAX_HUMAN (see all proteins):DKFZp686G1650 TRAX DISC1
TSNAX for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSNAX
PGOHUM00000247742
|
Genomic Variants
for TSNAX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSNAX (231664287 - 231702270 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TSNAX
3 CNVs: 84900 48275 3334
1 Indel: 84901 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSNAX |
|
Disorders
/ Diseases
for TSNAX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSNAX for disorders About GeneDecksing
OMIM gene information: 602964
OMIM disorders: --
4  diseases for TSNAX: About MalaCardsmajor depressive disorder bipolar disorder schizophrenia carcinoma
2 diseases from the University of Copenhagen DISEASES database for TSNAX:Schizophrenia Major depressive disorder 1 Novoseek disease relationship for TSNAX gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
37.9 |
9 |
16275808 (3), 10945471 (1), 16103888 (1) |
Genetic Association Database (GAD): TSNAX
Human Genome Epidemiology (HuGE) Navigator: TSNAX (8 documents)
Export disorders for TSNAX gene to outside databases
|
Publications
for TSNAX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSNAX gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with TSNAX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of a cDNA encoding a translin-like protein, TRAX. (PubMed id 9013868)1, 2, 3 Aoki K.... Kasai M. (1997)
- Co-expressed recombinant human Translin-Trax complex binds DNA. (PubMed id 15919079)1, 2, 9 Gupta G.D....Rao B.J. (2005)
- Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. (PubMed id 16275808)1, 4, 9 Cannon T.D....Peltonen L. (2005)
- Structure of C3PO and mechanism of human RISC activat ion. (PubMed id 21552258)1, 2 Ye X....Zhang H. (2011)
- Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (2005)
- Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. (PubMed id 15838535)1, 4 Thomson P.A....Porteous D.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. (PubMed id 12036294)1, 2 Bray J.D.... Hecht N.B. (2002)
- DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). (PubMed id 11801738)1, 2 Erdemir T.... Yavuzer U. (2002)
- Chromosomal location and genomic structure of the human translin- associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. (PubMed id 10945471)1, 9 Millar J.K.... Porteous D.J. (2000)
|
External Searches for TSNAX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSNAX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSNAX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSNAX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TSNAX gene:
Search GeneIP for patents involving TSNAX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSNAX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSNAX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSNAX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSNAX | | | OriGene Protein Over-expression Lysate for TSNAX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSNAX | | OriGene 3'-UTR Clone for TSNAX | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSNAX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSNAX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSNAX | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSNAX | | OriGene Custom Protein Services for TSNAX | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSNAX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSNAX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSNAX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSNAX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSNAX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSNAX |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TSNAX |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TSNAX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSNAX |
|  |  |  | | | | Search ThermoFisher Antibodies for TSNAX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSNAX |
|
|
|
|
