Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSNAX Gene

Aliases for TSNAX Gene

  • Translin-Associated Factor X 2 3 4
  • TRAX 3 4 6
  • Translin-Associated Protein X 3
  • Translin-Like Protein 3

External Ids for TSNAX Gene

Previous GeneCards Identifiers for TSNAX Gene

  • GC01P230110
  • GC01P227404
  • GC01P228137
  • GC01P228699
  • GC01P227971
  • GC01P229730
  • GC01P231664
  • GC01P202148

Summaries for TSNAX Gene

Entrez Gene Summary for TSNAX Gene

  • This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSNAX Gene

TSNAX (Translin-Associated Factor X) is a Protein Coding gene. Diseases associated with TSNAX include schizophrenia. GO annotations related to this gene include sequence-specific DNA binding and protein transporter activity. An important paralog of this gene is TSNAX-DISC1.

UniProtKB/Swiss-Prot for TSNAX Gene

  • Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.

Gene Wiki entry for TSNAX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSNAX Gene

Genomics for TSNAX Gene

Regulatory Elements for TSNAX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSNAX Gene

231,528,653 bp from pter
231,566,524 bp from pter
37,872 bases
Plus strand

Genomic View for TSNAX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSNAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSNAX Gene

Proteins for TSNAX Gene

  • Protein details for TSNAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Translin-associated protein X
    Protein Accession:
    Secondary Accessions:
    • B1APC6

    Protein attributes for TSNAX Gene

    290 amino acids
    Molecular mass:
    33112 Da
    Quaternary structure:
    • Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.

    Three dimensional structures from OCA and Proteopedia for TSNAX Gene

neXtProt entry for TSNAX Gene

Proteomics data for TSNAX Gene at MOPED

Post-translational modifications for TSNAX Gene

Other Protein References for TSNAX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSNAX Gene

Domains for TSNAX Gene

Protein Domains for TSNAX Gene


Suggested Antigen Peptide Sequences for TSNAX Gene

Graphical View of Domain Structure for InterPro Entry



  • Q99598
  • Belongs to the translin family.
genes like me logo Genes that share domains with TSNAX: view

No data available for Gene Families for TSNAX Gene

Function for TSNAX Gene

Molecular function for TSNAX Gene

UniProtKB/Swiss-Prot Function:
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for TSNAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9013868
GO:0003697 single-stranded DNA binding IBA --
GO:0004521 endoribonuclease activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008565 protein transporter activity TAS 9013868
genes like me logo Genes that share ontologies with TSNAX: view

Phenotypes for TSNAX Gene

GenomeRNAi human phenotypes for TSNAX:
genes like me logo Genes that share phenotypes with TSNAX: view

Animal Model Products

CRISPR Products

miRNA for TSNAX Gene

miRTarBase miRNAs that target TSNAX

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSNAX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSNAX Gene

Localization for TSNAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSNAX Gene

Cytoplasm, perinuclear region. Golgi apparatus. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TSNAX Gene COMPARTMENTS Subcellular localization image for TSNAX gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TSNAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSNAX: view

Pathways for TSNAX Gene

SuperPathways for TSNAX Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSNAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0010467 gene expression TAS --
GO:0015031 protein transport TAS 9013868
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSNAX: view

No data available for Pathways by source for TSNAX Gene

Transcripts for TSNAX Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSNAX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSNAX Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: -
SP3: - - -
SP4: -

Relevant External Links for TSNAX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSNAX Gene

mRNA expression in normal human tissues for TSNAX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TSNAX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0), Lymph node (8.0), and Heart (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSNAX Gene

genes like me logo Genes that share expressions with TSNAX: view

Expression partners for TSNAX Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSNAX Gene

Orthologs for TSNAX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSNAX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSNAX 35
  • 92.99 (n)
  • 97.24 (a)
  • 97 (a)
(Canis familiaris)
Mammalia TSNAX 35
  • 94.37 (n)
  • 97.24 (a)
  • 72 (a)
(Mus musculus)
Mammalia Tsnax 35
  • 85.63 (n)
  • 90.69 (a)
Tsnax 16
Tsnax 36
  • 91 (a)
(Pan troglodytes)
Mammalia TSNAX 35
  • 99.77 (n)
  • 99.66 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tsnax 35
  • 82.76 (n)
  • 90.34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
(Gallus gallus)
Aves TSNAX 35
  • 74.95 (n)
  • 76.36 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15324 35
tsnax 35
  • 67.94 (n)
  • 65.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64311 35
(Danio rerio)
Actinopterygii tsnax 35
  • 62.75 (n)
  • 65.12 (a)
tsnax 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8661 35
fruit fly
(Drosophila melanogaster)
Insecta CG5063 37
  • 35 (a)
Trax 35
  • 45.04 (n)
  • 39.31 (a)
Trax 36
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004585 35
  • 48.99 (n)
  • 37.72 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G03780 35
  • 51.25 (n)
  • 38.77 (a)
(Oryza sativa)
Liliopsida Os01g0265900 35
  • 54.93 (n)
  • 44.8 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06059 35
  • 44.53 (n)
  • 33.2 (a)
Species with no ortholog for TSNAX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSNAX Gene

Gene Tree for TSNAX (if available)
Gene Tree for TSNAX (if available)

Paralogs for TSNAX Gene

Paralogs for TSNAX Gene

Selected SIMAP similar genes for TSNAX Gene using alignment to 2 proteins: Pseudogenes for TSNAX Gene

genes like me logo Genes that share paralogs with TSNAX: view

Variants for TSNAX Gene

Structural Variations from Database of Genomic Variants (DGV) for TSNAX Gene

Variant ID Type Subtype PubMed ID
nsv873293 CNV Gain 21882294
dgv544n71 CNV Loss 21882294
dgv187e1 CNV Complex 17122850
nsv516935 CNV Gain 19592680

Relevant External Links for TSNAX Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TSNAX Gene

Disorders for TSNAX Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TSNAX Gene in MalaCards »

(1) Diseases for TSNAX Gene including...

(2) University of Copenhagen DISEASES for TSNAX Gene

(1) Novoseek inferred disease relationships for TSNAX Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 37.9 5

Relevant External Links for TSNAX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TSNAX: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for TSNAX Gene

Publications for TSNAX Gene

  1. Co-expressed recombinant human Translin-Trax complex binds DNA. (PMID: 15919079) Gupta G.D. … Rao B.J. (FEBS Lett. 2005) 3 4 23
  2. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. (PMID: 16275808) Cannon T.D. … Peltonen L. (Arch. Gen. Psychiatry 2005) 3 23 48
  3. Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population. (PMID: 19760522) Okuda A. … Iwata N. (Neuromolecular Med. 2010) 3 23 48
  4. Isolation and characterization of a cDNA encoding a translin-like protein, TRAX. (PMID: 9013868) Aoki K. … Kasai M. (FEBS Lett. 1997) 2 3 4
  5. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E. … Estivill X. (J Psychiatr Res 2010) 3 48

Products for TSNAX Gene

Sources for TSNAX Gene

Back to Top