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Aliases for TSNARE1 Gene

Aliases for TSNARE1 Gene

  • T-SNARE Domain Containing 1 2 3 5

External Ids for TSNARE1 Gene

Previous GeneCards Identifiers for TSNARE1 Gene

  • GC08M143292
  • GC08M138547

Summaries for TSNARE1 Gene

GeneCards Summary for TSNARE1 Gene

TSNARE1 (T-SNARE Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include SNARE binding and SNAP receptor activity. An important paralog of this gene is STX12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSNARE1 Gene

Genomics for TSNARE1 Gene

Regulatory Elements for TSNARE1 Gene

Promoters for TSNARE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSNARE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSNARE1 Gene

Chromosome:
8
Start:
142,212,080 bp from pter
End:
142,403,291 bp from pter
Size:
191,212 bases
Orientation:
Minus strand

Genomic View for TSNARE1 Gene

Genes around TSNARE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSNARE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSNARE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSNARE1 Gene

Proteins for TSNARE1 Gene

  • Protein details for TSNARE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NA8-TSNA1_HUMAN
    Recommended name:
    t-SNARE domain-containing protein 1
    Protein Accession:
    Q96NA8
    Secondary Accessions:
    • B7ZLB0
    • Q14D03

    Protein attributes for TSNARE1 Gene

    Size:
    513 amino acids
    Molecular mass:
    55949 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSNARE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSNARE1 Gene

Proteomics data for TSNARE1 Gene at MOPED

Post-translational modifications for TSNARE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSNARE1 Gene

No data available for DME Specific Peptides for TSNARE1 Gene

Domains & Families for TSNARE1 Gene

Protein Domains for TSNARE1 Gene

Suggested Antigen Peptide Sequences for TSNARE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NA8

UniProtKB/Swiss-Prot:

TSNA1_HUMAN :
  • Contains 1 t-SNARE coiled-coil homology domain.
Domain:
  • Contains 1 t-SNARE coiled-coil homology domain.
genes like me logo Genes that share domains with TSNARE1: view

No data available for Gene Families for TSNARE1 Gene

Function for TSNARE1 Gene

Gene Ontology (GO) - Molecular Function for TSNARE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
genes like me logo Genes that share ontologies with TSNARE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSNARE1 Gene

Localization for TSNARE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSNARE1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSNARE1 Gene COMPARTMENTS Subcellular localization image for TSNARE1 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSNARE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with TSNARE1: view

Pathways & Interactions for TSNARE1 Gene

SuperPathways for TSNARE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSNARE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TSNARE1: view

No data available for Pathways by source and SIGNOR curated interactions for TSNARE1 Gene

Drugs & Compounds for TSNARE1 Gene

No Compound Related Data Available

Transcripts for TSNARE1 Gene

Unigene Clusters for TSNARE1 Gene

T-SNARE domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSNARE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - - - - -
SP3:
SP4:

Relevant External Links for TSNARE1 Gene

GeneLoc Exon Structure for
TSNARE1
ECgene alternative splicing isoforms for
TSNARE1

Expression for TSNARE1 Gene

mRNA expression in normal human tissues for TSNARE1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSNARE1 Gene



SOURCE GeneReport for Unigene cluster for TSNARE1 Gene Hs.370931

genes like me logo Genes that share expression patterns with TSNARE1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSNARE1 Gene

Orthologs for TSNARE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSNARE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSNARE1 35
  • 84.65 (n)
  • 80.4 (a)
TSNARE1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSNARE1 35
  • 83.65 (n)
  • 78.9 (a)
TSNARE1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSNARE1 35
  • 99.45 (n)
  • 99.17 (a)
TSNARE1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSNARE1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSNARE1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSNARE1 35
  • 70.04 (n)
  • 69.29 (a)
TSNARE1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSNARE1 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tsnare1 35
  • 66.16 (n)
  • 60.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882035 35
  • 61.82 (n)
  • 56.06 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011727 35
  • 23.26 (n)
  • 6.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx13 35
  • 46.87 (n)
  • 31.62 (a)
Syx13 36
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP12 36
  • 19 (a)
OneToMany
Species with no ortholog for TSNARE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSNARE1 Gene

ENSEMBL:
Gene Tree for TSNARE1 (if available)
TreeFam:
Gene Tree for TSNARE1 (if available)

Paralogs for TSNARE1 Gene

Paralogs for TSNARE1 Gene

(2) SIMAP similar genes for TSNARE1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for TSNARE1 Gene

genes like me logo Genes that share paralogs with TSNARE1: view

Variants for TSNARE1 Gene

Sequence variations from dbSNP and Humsavar for TSNARE1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs33970858 - 142,345,817(+) CACAG(A/C/G/T)GGTTC intron-variant, nc-transcript-variant, reference, missense
rs10100935 - 142,344,359(+) GGTAG(C/T)GCTGG intron-variant, nc-transcript-variant, reference, missense
rs10435683 - 142,331,775(+) GAAGA(C/T)GTTGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs7814359 - 142,354,673(+) CCCGA(A/G)AGGGC nc-transcript-variant, reference, missense
rs4307453 -- 142,233,800(+) AGCCC(A/C)ACCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSNARE1 Gene

Variant ID Type Subtype PubMed ID
dgv7908n71 CNV Loss 21882294
nsv891604 CNV Loss 21882294
dgv7909n71 CNV Loss 21882294
nsv891611 CNV Loss 21882294
nsv509289 CNV Insertion 20534489
nsv891612 CNV Loss 21882294
esv2737848 CNV Deletion 23290073
esv2737849 CNV Deletion 23290073
esv2737850 CNV Deletion 23290073
esv2737852 CNV Deletion 23290073
esv2737853 CNV Deletion 23290073
esv2667296 CNV Deletion 23128226
esv2737854 CNV Deletion 23290073
esv2737855 CNV Deletion 23290073
esv2360167 CNV Deletion 18987734
esv4332 CNV Deletion 18987735
esv2165770 CNV Deletion 18987734
dgv1283e201 CNV Deletion 23290073
esv2737857 CNV Deletion 23290073
esv2737858 CNV Deletion 23290073
nsv465984 CNV Loss 19166990
esv29885 CNV Gain 19812545
esv273375 CNV Insertion 20981092
esv267466 CNV Insertion 20981092
esv2737859 CNV Deletion 23290073
esv2737860 CNV Deletion 23290073
esv1000488 CNV Deletion 20482838
esv1113323 CNV Deletion 17803354
esv2737861 CNV Deletion 23290073
esv2661137 CNV Deletion 23128226
nsv510175 CNV Loss 20534489
nsv891613 CNV Loss 21882294
esv2737863 CNV Deletion 23290073
esv1259156 CNV Insertion 17803354
nsv824754 CNV Gain 20364138
nsv465985 CNV Loss 19166990
esv2677095 CNV Deletion 23128226
esv2737864 CNV Deletion 23290073
nsv891614 CNV Loss 21882294
esv2737865 CNV Deletion 23290073
esv1035238 CNV Insertion 17803354
esv2675619 CNV Deletion 23128226
esv2737866 CNV Deletion 23290073
esv1527734 CNV Insertion 17803354
esv2737867 CNV Deletion 23290073
esv2737868 CNV Deletion 23290073
esv2737869 CNV Deletion 23290073
nsv465986 CNV Loss 19166990
dgv1313e199 CNV Deletion 23128226
esv23184 CNV Loss 19812545
esv2737870 CNV Deletion 23290073
esv33359 CNV Gain 17666407
nsv465987 CNV Loss 19166990
esv2737871 CNV Deletion 23290073
esv1364719 CNV Insertion 17803354
nsv396730 CNV Loss 16902084
esv2737872 CNV Deletion 23290073
esv2737874 CNV Deletion 23290073
dgv1284e201 CNV Deletion 23290073
esv2737876 CNV Deletion 23290073
nsv891615 CNV Gain 21882294
dgv2262e1 CNV Complex 17122850
esv24772 CNV Loss 19812545
esv2737878 CNV Deletion 23290073
nsv8393 CNV Gain 18304495

Variation tolerance for TSNARE1 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.41; 97.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSNARE1 Gene

HapMap Linkage Disequilibrium report
TSNARE1
Human Gene Mutation Database (HGMD)
TSNARE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSNARE1 Gene

Disorders for TSNARE1 Gene

Relevant External Links for TSNARE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSNARE1

No disorders were found for TSNARE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSNARE1 Gene

Publications for TSNARE1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3
  5. GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus. (PMID: 24166486) Sleiman P. … Hakonarson H. (Sci Rep 2013) 3

Products for TSNARE1 Gene

Sources for TSNARE1 Gene

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