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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSN Gene

protein-coding   GIFtS: 54
GCID: GC02P122419

Translin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
translin1 2     REHF-12
Recombination Hotspot Associated Factor1 2     TBRBP2
Component 3 Of Promoter Of RISC2 3     TRSLN2
C3PO2 3     Recombination Hotspot-Binding Protein2
BCLF-12     Testis Brain-RNA Binding Protein2
RCHF12     EC 3.1.-.-3

External Ids:    HGNC: 123791   Entrez Gene: 72472   Ensembl: ENSG000002114607   OMIM: 6005755   UniProtKB: Q156313   

Export aliases for TSN gene to outside databases

Previous GC identifers: GC02P119718 GC02P120433 GC02P122608 GC02P122229 GC02P114835


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSN Gene:
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint
junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for
its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination
hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding
activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by
this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that
promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, May 2012)

GeneCards Summary for TSN Gene: 
TSN (translin) is a protein-coding gene. Diseases associated with TSN include myxoid liposarcoma, and liposarcoma. GO annotations related to this gene include sequence-specific DNA binding and endonuclease activity.

UniProtKB/Swiss-Prot: TSN_HUMAN, Q15631
Function: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in
chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to
recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots
Function: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of
RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand

Gene Wiki entry for TSN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSN gene promoter:
         AhR   Olf-1   GATA-1   Arnt   Evi-1   PPAR-alpha   FOXC1   NRF-2   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSN promoter sequence
   Search SABiosciences Chromatin IP Primers for TSN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q21.1

TSN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P122419:  view genomic region     (about GC identifiers)

Start:
122,494,679 bp from pter      End:
122,525,429 bp from pter
Size:
30,751 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSN_HUMAN, Q15631 (See protein sequence)
Recommended Name: Translin  
Size: 228 amino acids; 26183 Da
Subunit: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring
Subcellular location: Cytoplasm. Nucleus
3 PDB 3D structures from and Proteopedia for TSN:
1J1J (3D)        3PJA (3D)        3QB5 (3D)    
Secondary accessions: B7Z3X8 Q5U0K7
Alternative splicing: 2 isoforms:  Q15631-1   Q15631-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSN: NX_Q15631

Explore proteomics data for TSN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15631

  • TSN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001248330.1  NP_004613.1  

    ENSEMBL proteins: 
     ENSP00000399735   ENSP00000374332   ENSP00000387263   ENSP00000437728  

    Human Recombinant Protein Products for TSN: 
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    OriGene Protein Over-expression Lysate for TSN
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    OriGene Custom Protein Services for TSN
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    Novus Biologicals TSN Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TSN
    Cloud-Clone Corp. Proteins for TSN 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    TSN for ontologies           About GeneDecksing



    TSN Antibody Products: 
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    Novus Biologicals TSN Antibodies
    Abcam antibodies for TSN
    Cloud-Clone Corp. Antibodies for TSN 
    ThermoFisher Antibodies for TSN
    LSBio Antibodies in human, mouse, rat for TSN 

    Assay Products for TSN: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSN 
    Cloud-Clone Corp. CLIAs for TSN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016069 Translin_C
     IPR002848 Translin
     IPR016068 Translin_N

    Graphical View of Domain Structure for InterPro Entry Q15631

    ProtoNet protein and cluster: Q15631

    1 Blocks protein domain: IPB002848 Translin

    UniProtKB/Swiss-Prot: TSN_HUMAN, Q15631
    Similarity: Belongs to the translin family


    TSN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSN_HUMAN, Q15631
    Function: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in
    chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to
    recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots
    Function: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of
    RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand

         Genatlas biochemistry entry for TSN:
    translin,recombinational hot spot protein,expressed in brain and testis,dimerizing DNA binding protein at the
    breakpoint junctions in chromosomal translocations,involved in DNA damage repair and in mRNA transport

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS7663511
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IEA--
    GO:0004519endonuclease activity IEA--
    GO:0005515protein binding IPI--
         
    TSN for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tsn):
     adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  growth/size 
     hematopoietic system  immune system  reproductive system 

    TSN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSN
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate TSN (see all 34):
    hsa-miR-582-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-449a hsa-miR-124 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidTSN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSN

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TSN

    Clone
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    OriGene clones in human, mouse for TSN (see all 7)
    OriGene ORF clones in mouse, rat for TSN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TSN (NM_003024)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSN
    Sirion Biotech Customized lentivirus for stable overexpression of TSN 
                         Customized lentivirus expression plasmids for stable overexpression of TSN 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/19 Interacting proteins for TSN (Q156311, 2, 3 ENSP000003743324) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSNAXQ995982, 3, ENSP000003555994MINT-60097 I2D: score=8 STRING: ENSP00000355599
    SAP18O004223, ENSP000003719734I2D: score=2 STRING: ENSP00000371973
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PPP1R15AO758073, ENSP000002004534I2D: score=3 STRING: ENSP00000200453
    GIT2Q141611, ENSP000003474644EBI-1044160,EBI-1046878 STRING: ENSP00000347464
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006310DNA recombination TAS7663511

    TSN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TSN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSN

    2 Novoseek inferred chemical compound relationships for TSN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 30.7 2 9244443 (1), 10025964 (1)
    oligonucleotide 29 4 11705401 (3), 12358744 (1)

    Search CenterWatch for drugs/clinical trials and news about TSN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSN gene (2 alternative transcripts): 
    NM_001261401.1  NM_004622.2  

    Unigene Cluster for TSN:

    Translin
    Hs.75066  [show with all ESTs]
    Unigene Representative Sequence: NM_004622
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455432 ENST00000389682(uc002tnl.3 uc002tnm.3 uc010yze.2 uc010flt.3)
    ENST00000467324 ENST00000483698 ENST00000490717 ENST00000478165 ENST00000498545
    ENST00000490104 ENST00000495112 ENST00000481818 ENST00000409193 ENST00000536142

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSN
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate TSN (see all 34):
    hsa-miR-582-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-449a hsa-miR-124 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidTSN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSN
    Clone
    Products:
         
    OriGene clones in human, mouse for TSN (see all 7)
    OriGene ORF clones in mouse, rat for TSN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TSN (NM_003024)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSN
    Sirion Biotech Customized lentivirus for stable overexpression of TSN 
                         Customized lentivirus expression plasmids for stable overexpression of TSN 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSN
    OriGene qSTAR qPCR primer pairs in human, mouse for TSN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSN

    Additional mRNA sequence: 

    AK091915.1 AK222868.1 AK296469.1 AK298812.1 AK307344.1 AK311410.1 AK315763.1 AL122099.1 
    BC002359.1 BT019490.1 BT019491.1 NR_048556.1 NR_048557.1 NR_048558.1 NR_048559.1 X78627.1 
    X95076.1 Z36850.1 

    19 DOTS entries:

    DT.422429  DT.99984499  DT.100798800  DT.95199452  DT.100798790  DT.120977200  DT.99988753  DT.100042133 
    DT.100042132  DT.100798796  DT.428139  DT.92446486  DT.92446493  DT.95199449  DT.120977128  DT.120977185 
    DT.120977189  DT.95199423  DT.100798795 

    24/341 AceView cDNA sequences (see all 341):

    AI039552 AA885303 BU192535 CA396218 CA444579 BQ439924 AA731750 AA401440 
    BX096228 BU165737 BQ015681 AA503746 X78627 BU195038 BM461651 BM834911 
    BQ011481 AL533554 AA502390 AI670723 AK091915 CB159932 AA460927 BQ270816 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATAACTA
    TSN Expression
    About this image


    See TSN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSN

    SOURCE GeneReport for Unigene cluster: Hs.75066
        SABiosciences Custom PCR Arrays for TSN
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TSN gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsn1 , 5 translin1, 5 90.2(n)1
    98.68(a)1
      1 (52.14 cM)5
    220991  NM_011650.31  NP_035780.11 
     1182985175 
    chicken
    (Gallus gallus)
    Aves TSN1 translin 77.78(n)
    86.4(a)
      395955  NM_205073.1  NP_990404.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSN6
    translin
    84(a)
    1 ↔ 1
    1(83934408-83974065)
    African clawed frog
    (Xenopus laevis)
    Amphibia tsn-prov2 translin 77.07(n)    BC044957.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsn1 translin 71.45(n)
    79.82(a)
      334107  NM_001025452.1  NP_001020623.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117613
    trsn1
    DNA binding3
    translin1
    52(a)3
    53.27(n)1
    53.27(a)1
      47A113
    361101  NM_136747.31  NP_610591.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G370201 translin-like protein 50.64(n)
    41.35(a)
      818276  NM_129258.4  NP_565857.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g04432001 hypothetical protein 46.12(n)
    38.83(a)
      4348736  NM_001071238.1  NP_001064703.1 


    ENSEMBL Gene Tree for TSN (if available)
    TreeFam Gene Tree for TSN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSN gene

    TSN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TSN
    PGOHUM00000260372


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/326 SNPs in TSN are shown (see all 326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs67491551,2
    C,F,H--122511135(+) agaagG/Cgaaca 6 -- us2k17Minor allele frequency- C:0.09NS EA WA NA 776
    rs1500193881,2
    --122511248(+) AGGGTC/GTCACT 6 -- us2k10--------
    rs1910175781,2
    C--122511303(+) CAGCCA/GTGGCA 6 -- us2k10--------
    rs1145739541,2
    C,F--122511461(+) TCAAGT/CGATCC 6 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1812654371,2
    --122511618(+) AGGGTA/CTAATT 6 -- us2k10--------
    rs749506411,2
    C--122511653(+) AAAAGC/GCTTAT 6 -- us2k10--------
    rs1865251461,2
    --122511705(+) CTAAAC/TGGTTA 6 -- us2k10--------
    rs75620211,2
    C,F,A,H--122511856(+) aaCAAT/CAACGA 6 -- us2k17Minor allele frequency- C:0.09NS EA WA NA 774
    rs1400464851,2
    --122511908(+) GCTTGA/TGTGCC 6 -- us2k10--------
    rs134249581,2
    C,H--122511919(+) TAACTC/TTAGGT 6 -- us2k15Minor allele frequency- T:0.00NS EA NA 420

    HapMap Linkage Disequilibrium report for TSN (122494679 - 122525429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834351CNV Loss17160897
    nsv459163CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600575    OMIM disorders: --

    20 diseases for TSN:    About MalaCards
    myxoid liposarcoma    liposarcoma    extraskeletal myxoid chondrosarcoma    myxoid chondrosarcoma
    sotos syndrome    alveolar rhabdomyosarcoma    botulism    dysgerminoma
    chondrosarcoma    synovial sarcoma    lung adenocarcinoma    rhabdomyosarcoma
    hepatitis c    sarcoma    obesity    adenocarcinoma
    hepatocellular carcinoma    hepatitis    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TSN:
    Botulism

    TSN for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TSN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoid neoplasm 54.7 2 9244443 (1), 11126370 (1)
    liposarcoma 38.6 5 11126370 (3), 9989822 (2)

    Genetic Association Database (GAD): TSN

    Export disorders for TSN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSN gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with TSN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein. (PubMed id 9244443)1, 2, 3, 9 Aoki K.... Kasai M. (1997)
    2. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. (PubMed id 7663511)1, 2, 9 Aoki K.... Kasai M. (1995)
    3. The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome. (PubMed id 9111049)1, 2, 9 Kasai M.... Suzuki K. (1997)
    4. Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11). (PubMed id 7947454)1, 3, 9 Kasai M....Strominger J.L. (1994)
    5. Structure of C3PO and mechanism of human RISC activat ion. (PubMed id 21552258)1, 2 Ye X....Zhang H. (2011)
    6. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (2010)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). (PubMed id 11801738)1, 2 Erdemir T.... Yavuzer U. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7247 HGNC: 12379 AceView: TSN Ensembl:ENSG00000211460 euGenes: HUgn7247
    ECgene: TSN H-InvDB: TSN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSN gene:
    Search GeneIP for patents involving TSN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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