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Aliases for TSN Gene

Aliases for TSN Gene

  • Translin 2 3
  • Recombination Hotspot Associated Factor 2 3
  • Component 3 Of Promoter Of RISC 3 4
  • C3PO 3 4
  • Recombination Hotspot-Binding Protein 3
  • Testis Brain-RNA Binding Protein 3
  • EC 3.1.-.- 4
  • BCLF-1 3
  • REHF-1 3
  • RCHF1 3
  • TBRBP 3
  • TRSLN 3

External Ids for TSN Gene

Previous GeneCards Identifiers for TSN Gene

  • GC02P119718
  • GC02P120433
  • GC02P122419
  • GC02P122608
  • GC02P122229
  • GC02P114835

Summaries for TSN Gene

Entrez Gene Summary for TSN Gene

  • This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for TSN Gene

TSN (Translin) is a Protein Coding gene. Diseases associated with TSN include liposarcoma. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include sequence-specific DNA binding and protein complex binding.

UniProtKB/Swiss-Prot for TSN Gene

  • DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots

  • Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand

Gene Wiki entry for TSN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSN Gene

Genomics for TSN Gene

Regulatory Elements for TSN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSN Gene

Chromosome:
2
Start:
121,737,103 bp from pter
End:
121,767,853 bp from pter
Size:
30,751 bases
Orientation:
Plus strand

Genomic View for TSN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSN Gene

Proteins for TSN Gene

  • Protein details for TSN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15631-TSN_HUMAN
    Recommended name:
    Translin
    Protein Accession:
    Q15631
    Secondary Accessions:
    • B7Z3X8
    • Q5U0K7

    Protein attributes for TSN Gene

    Size:
    228 amino acids
    Molecular mass:
    26183 Da
    Quaternary structure:
    • Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

    Three dimensional structures from OCA and Proteopedia for TSN Gene

    Alternative splice isoforms for TSN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSN Gene

Proteomics data for TSN Gene at MOPED

Post-translational modifications for TSN Gene

  • Ubiquitination at Lys 56, Lys 187, and Lys 219
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TSN Gene

Domains & Families for TSN Gene

Protein Domains for TSN Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15631

UniProtKB/Swiss-Prot:

TSN_HUMAN :
  • Belongs to the translin family.
Family:
  • Belongs to the translin family.
genes like me logo Genes that share domains with TSN: view

No data available for Gene Families for TSN Gene

Function for TSN Gene

Molecular function for TSN Gene

GENATLAS Biochemistry:
translin,recombinational hot spot protein,expressed in brain and testis,dimerizing DNA binding protein at the breakpoint junctions in chromosomal translocations,involved in DNA damage repair and in mRNA transport
UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots
UniProtKB/Swiss-Prot Function:
Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand

Enzyme Numbers (IUBMB) for TSN Gene

Gene Ontology (GO) - Molecular Function for TSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 7663511
GO:0003697 single-stranded DNA binding IBA --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IEA --
GO:0004521 endoribonuclease activity IBA --
genes like me logo Genes that share ontologies with TSN: view
genes like me logo Genes that share phenotypes with TSN: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSN

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TSN Gene

Localization for TSN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSN Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSN Gene COMPARTMENTS Subcellular localization image for TSN gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TSN: view

Pathways & Interactions for TSN Gene

genes like me logo Genes that share pathways with TSN: view

Pathways by source for TSN Gene

Gene Ontology (GO) - Biological Process for TSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination TAS 7663511
GO:0010467 gene expression TAS --
GO:0031047 gene silencing by RNA TAS --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IBA --
genes like me logo Genes that share ontologies with TSN: view

No data available for SIGNOR curated interactions for TSN Gene

Drugs & Compounds for TSN Gene

(1) Drugs for TSN Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
leucine Nutra 93

(1) Additional Compounds for TSN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oligonucleotide
genes like me logo Genes that share compounds with TSN: view

Transcripts for TSN Gene

Unigene Clusters for TSN Gene

Translin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSN Gene

No ASD Table

Relevant External Links for TSN Gene

GeneLoc Exon Structure for
TSN
ECgene alternative splicing isoforms for
TSN

Expression for TSN Gene

mRNA expression in normal human tissues for TSN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSN Gene



SOURCE GeneReport for Unigene cluster for TSN Gene Hs.75066

genes like me logo Genes that share expression patterns with TSN: view

Protein tissue co-expression partners for TSN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSN Gene

Orthologs for TSN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSN 35
  • 91.67 (n)
  • 99.56 (a)
TSN 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSN 35
  • 94.88 (n)
  • 99.12 (a)
TSN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsn 35
  • 90.2 (n)
  • 98.68 (a)
Tsn 16
Tsn 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSN 35
  • 99.85 (n)
  • 100 (a)
TSN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsn 35
  • 90.64 (n)
  • 99.12 (a)
oppossum
(Monodelphis domestica)
Mammalia TSN 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSN 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSN 35
  • 77.78 (n)
  • 86.4 (a)
TSN 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSN 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mllt4 35
  • 71.85 (n)
  • 77.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia tsn-prov 35
zebrafish
(Danio rerio)
Actinopterygii tsn 35
  • 71.28 (n)
  • 79.46 (a)
tsn 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10580 35
fruit fly
(Drosophila melanogaster)
Insecta CG11761 37
  • 52 (a)
trsn 35
  • 53.27 (n)
  • 53.27 (a)
trsn 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005538 35
  • 54.41 (n)
  • 53.36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37020 35
  • 52.18 (n)
  • 43.46 (a)
rice
(Oryza sativa)
Liliopsida Os10g0443200 35
  • 47.08 (n)
  • 40.21 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06664 35
  • 46.7 (n)
  • 37.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tsn1 35
  • 49.83 (n)
  • 41.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for TSN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSN Gene

ENSEMBL:
Gene Tree for TSN (if available)
TreeFam:
Gene Tree for TSN (if available)

Paralogs for TSN Gene

Pseudogenes.org Pseudogenes for TSN Gene

genes like me logo Genes that share paralogs with TSN: view

No data available for Paralogs for TSN Gene

Variants for TSN Gene

Sequence variations from dbSNP and Humsavar for TSN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs287795 -- 121,760,910(+) ctgtc(A/G)ttcag intron-variant
rs287796 -- 121,763,174(+) gtccc(A/G)ctctg intron-variant
rs6710934 -- 121,763,621(+) TTAAC(A/C)GATGA intron-variant
rs6713200 -- 121,760,033(+) ggcca(C/T)ggact intron-variant
rs6716001 -- 121,765,903(+) GGAAT(C/T)ATAGC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TSN Gene

Variant ID Type Subtype PubMed ID
nsv459163 CNV Gain 19166990
nsv834351 CNV Loss 17160897

Variation tolerance for TSN Gene

Residual Variation Intolerance Score: 30.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSN Gene

HapMap Linkage Disequilibrium report
TSN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSN Gene

Disorders for TSN Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSN Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
liposarcoma
- elite association
Search TSN in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSN

Genetic Association Database (GAD)
TSN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSN
genes like me logo Genes that share disorders with TSN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSN Gene

Publications for TSN Gene

  1. Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein. (PMID: 9244443) Aoki K. … Kasai M. (Genomics 1997) 2 23 67
  2. Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11). (PMID: 7947454) Kasai M. … Strominger J.L. (Int. Immunol. 1994) 2 23 67
  3. Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study. (PMID: 20081200) Eliahoo E. … Manor H. (Nucleic Acids Res. 2010) 23 67
  4. The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. (PMID: 19642973) Gimelli S. … Gimelli G. (Mol. Cancer 2009) 23 67
  5. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. (PMID: 19661431) Liu Y. … Liu Q. (Science 2009) 23 67

Products for TSN Gene

Sources for TSN Gene

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