Aliases for TSLP Gene
External Ids for TSLP Gene
- HGNC: 30743
- Entrez Gene: 85480
- Ensembl: ENSG00000145777
- OMIM: 607003
- UniProtKB: Q969D9
Previous GeneCards Identifiers for TSLP Gene
- GC05P110030
- GC05P110853
- GC05P110436
- GC05P110481
- GC05P110433
- GC05P110435
- GC05P110405
- GC05P105586
Summaries for TSLP Gene
-
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for TSLP Gene
TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Cryoglobulinemia, Familial Mixed and Cryoglobulinemia. Among its related pathways are Development and heterogeneity of the ILC family and Jak-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity.
UniProtKB/Swiss-Prot for TSLP Gene
-
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
-
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
Additional gene information for TSLP Gene
- Monarch Initiative
- Search for TSLP at DataMed
- Search for TSLP at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSLP Gene
Genomics for TSLP Gene
GeneHancer (GH) Regulatory Elements for TSLP Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH05I111072 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 595.6 | +3.3 | 3339 | 1.2 | ATF1 ARNT FEZF1 ZNF2 YY1 POLR2B GLIS2 KLF7 ATF7 ZNF263 | TSLP WDR36 | |
GH05I111071 | Promoter | 0.6 | EPDnew | 550.8 | +1.6 | 1632 | 0.1 | EZH2 | TSLP WDR36 | |
GH05I111069 | Enhancer | 0.5 | ENCODE | 603 | +0.1 | 120 | 1 | CTCF JUND SUZ12 POLR2A EZH2 | TSLP WDR36 | |
GH05I111091 | Promoter/Enhancer | 1.6 | Ensembl ENCODE | 44.8 | +22.8 | 22792 | 2.6 | CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 | WDR36 ENSG00000253613 RPS3AP21 TSLP SLC25A46 TMEM232 BCLAF1P1 STARD4-AS1 GC05P111128 | |
GH05I111223 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 10.4 | +161.6 | 161592 | 16.7 | HDGF PKNOX1 IRF4 ZNF121 GLIS2 ZNF207 ATF7 KLF7 FOS RUNX3 | CAMK4 WDR36 RPS3AP21 ENSG00000249318 TSLP GC05M111236 |
Regulatory Element Products
Genomic Locations for TSLP Gene
- chr5:111,070,062-111,078,024
- (GRCh38/hg38)
- Size:
- 7,963 bases
- Orientation:
- Plus strand
- chr5:110,405,760-110,413,722
- (GRCh37/hg19)
Genomic View for TSLP Gene
- Cytogenetic band:
-
- 5q22.1 by Ensembl
- 5q22.1 by Entrez Gene
- 5q22.1 by HGNC


RefSeq DNA sequence for TSLP Gene
Proteins for TSLP Gene
-
Protein details for TSLP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969D9-TSLP_HUMAN
- Recommended name:
- Thymic stromal lymphopoietin
- Protein Accession:
- Q969D9
- G3XAM8
- Q8IW99
- Q96AU7
Protein attributes for TSLP Gene
- Size:
- 159 amino acids
- Molecular mass:
- 18141 Da
- Quaternary structure:
-
- Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
- SequenceCaution:
-
- Sequence=AAH16720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for TSLP Gene
- Glycosylation at isoforms=64 and posLast=119119
Other Protein References for TSLP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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-
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Protein Products
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-
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-
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-
ProSci Proteins for TSLP
-
Abcam proteins for TSLP
No data available for DME Specific Peptides for TSLP Gene
Domains & Families for TSLP Gene
Gene Families for TSLP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for TSLP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TSLP Gene
Function for TSLP Gene
Molecular function for TSLP Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
- UniProtKB/Swiss-Prot Function:
- Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
- UniProtKB/Swiss-Prot Induction:
- Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.
Phenotypes From GWAS Catalog for TSLP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IMP | 17242164 |
GO:0005139 | interleukin-7 receptor binding | IMP | 11480573 |
Phenotypes for TSLP Gene
- MGI mutant phenotypes for TSLP:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for TSLP:
Animal Models for TSLP Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for TSLP gene
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for TSLP Gene
- miRTarBase miRNAs that target TSLP
-
- hsa-mir-335-5p (MIRT017769)
- hsa-mir-299-5p (MIRT527977)
- hsa-mir-5699-5p (MIRT527978)
- hsa-mir-4518 (MIRT527979)
- hsa-mir-1266-5p (MIRT527980)
- hsa-mir-6793-3p (MIRT527981)
- hsa-mir-6754-5p (MIRT527982)
- hsa-mir-4441 (MIRT527983)
- hsa-mir-4270 (MIRT527984)
- hsa-mir-211-3p (MIRT527985)
- hsa-mir-6769a-3p (MIRT527986)
- hsa-mir-3943 (MIRT527987)
- hsa-mir-4323 (MIRT527988)
- hsa-mir-6732-3p (MIRT527989)
- hsa-mir-652-5p (MIRT527990)
miRNA Products
- Search ViGene Biosciences for TSLP
Inhibitory RNA Products
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-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TSLP gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
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-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSLP Gene
Localization for TSLP Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSLP Gene
- Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSLP Gene
Pathways & Interactions for TSLP Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling | ||
2 | Jak-STAT signaling pathway (KEGG) | ||
3 | Innate Lymphoid Cell Differentiation Pathways | ||
4 | Development and heterogeneity of the ILC family |
Pathways by source for TSLP Gene
1 BioSystems pathway for TSLP Gene
2 KEGG pathways for TSLP Gene
1 R&D Systems pathway for TSLP Gene
Interacting Proteins for TSLP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001961 | positive regulation of cytokine-mediated signaling pathway | IDA | 11418668 |
GO:0008284 | positive regulation of cell proliferation | IMP | 11480573 |
GO:0010469 | regulation of receptor activity | IEA | -- |
GO:0032722 | positive regulation of chemokine production | IDA | 11418668 |
GO:0032733 | positive regulation of interleukin-10 production | IMP | 17242164 |
Transcripts for TSLP Gene
mRNA/cDNA for TSLP Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TSLP Gene
CRISPR Products
-
OriGene CRISPR knockouts for TSLP
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
- Search ViGene Biosciences for TSLP
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TSLP
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TSLP gene related products
- orf clones - Search results for available TSLP gene related products
- Applied Biological Materials Clones for TSLP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TSLP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Kidney (Urinary System)
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for TSLP Gene
NURSA nuclear receptor signaling pathways regulating expression of TSLP Gene:
TSLPSOURCE GeneReport for Unigene cluster for TSLP Gene:
Hs.389874mRNA Expression by UniProt/SwissProt for TSLP Gene:
Q969D9-TSLP_HUMANEvidence on tissue expression from TISSUES for TSLP Gene
- Lung(4.5)
- Nervous system(4.2)
- Blood(2.6)
- Lymph node(2.6)
- Skin(2.6)
- Spleen(2.6)
Primer Products
-
OriGene qPCR primer pairs and template standards for TSLP
-
OriGene qPCR primer pairs for TSLP
- genomics-online: primer clones - Search results for available TSLP gene related products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSLP Gene
Orthologs for TSLP Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TSLP 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | LOC617637 33 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tslp 33 |
|
||
mouse (Mus musculus) |
Mammalia | Tslp 33 16 34 |
|
||
dog (Canis familiaris) |
Mammalia | TSLP 34 |
|
OneToOne |
- Species where no ortholog for TSLP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TSLP Gene
No data available for Paralogs for TSLP Gene
Variants for TSLP Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000002184 | -- | 111,073,714(+) | C/T | intron_variant | |
rs1000156319 | -- | 111,068,776(+) | A/G | upstream_transcript_variant | |
rs1000829748 | -- | 111,078,461(+) | G/A | downstream_transcript_variant | |
rs1001005242 | -- | 111,075,043(+) | G/A | intron_variant | |
rs1001110038 | -- | 111,070,079(+) | A/T | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5779n100 | CNV | gain | 25217958 |
dgv5780n100 | CNV | gain | 25217958 |
esv3606259 | CNV | loss | 21293372 |
nsv1025735 | CNV | gain | 25217958 |
nsv830447 | CNV | loss | 17160897 |
Additional Variant Information for TSLP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSLP Gene
Disorders for TSLP Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
cryoglobulinemia, familial mixed |
|
|
cryoglobulinemia |
|
|
allergic asthma |
|
|
membranoproliferative glomerulonephritis |
|
|
eczema herpeticum |
|
|
Additional Disease Information for TSLP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TSLP Gene
Publications for TSLP Gene
- Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PMID: 11418668) Reche PA … Bazan JF (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 22 58
- Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PMID: 11480573) Quentmeier H … Lyman SD (Leukemia 2001) 2 3 4 22 58
- Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PMID: 20208534) Rothenberg ME … Hakonarson H (Nature genetics 2010) 3 22 44 58
- A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. (PMID: 19539984) He JQ … Daley D (The Journal of allergy and clinical immunology 2009) 3 22 44 58
- Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo. (PMID: 19555430) Cheong KA … Lee AY (Experimental dermatology 2009) 3 22 44 58
Products for TSLP Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 193 available TSLP Antibodies ranked by validation data
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Sources for TSLP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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