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TSLP Gene

protein-coding GIFtS: 57
GCID: GC05P110405

Thymic Stromal Lymphopoietin

See TSLP-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Thymic Stromal Lymphopoietin¹ ²

External Ids:	HGNC: 30743¹	Entrez Gene: 85480²	Ensembl: ENSG00000145777⁷	OMIM: 607003⁵	UniProtKB: Q969D9³

Export aliases for TSLP gene to outside databases

Previous GC identifers: GC05P110030 GC05P110853 GC05P110436 GC05P110481 GC05P110433 GC05P110435 GC05P105586

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSLP Gene:

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of

the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces

the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic

cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various

inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The

protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative

splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for TSLP Gene:

TSLP (thymic stromal lymphopoietin) is a protein-coding gene. Diseases associated with TSLP include eczema herpeticum, and chronic obstructive pulmonary disease. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9

Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular,

enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast

cells

Gene Wiki entry for TSLP (Thymic stromal lymphopoietin) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000005.9 NC_018916.2 NT_034772.7

Regulatory elements:

Regulatory transcription factor binding sites in the TSLP gene promoter:
MEF-2A STAT1 aMEF-2 STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSLP promoter sequence

Search Chromatin IP Primers for TSLP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSLP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.1 Ensembl cytogenetic band: 5q22.1 HGNC cytogenetic band: 5q22.1

TSLP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSLP gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P110405: view genomic region (about GC identifiers)

Start:	110,405,760 bp from pter	End:	110,413,722 bp from pter
Size:	7,963 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TSLP

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9 (See protein sequence)

Recommended Name: Thymic stromal lymphopoietin precursor

Size: 159 amino acids; 18141 Da

Subunit: Interacts with a receptor composed of CRLF2 and IL7R

Secondary accessions: Q8IW99

Explore the universe of human proteins at neXtProt for TSLP: NX_Q969D9

Explore proteomics data for TSLP at MOPED

Post-translational modifications:

Glycosylation² at Asn64, Asn119

Modification sites at PhosphoSitePlus

See TSLP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_149024.1 NP_612561.2

ENSEMBL proteins:

ENSP00000399099 ENSP00000339804 ENSP00000427827

TSLP Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for TSLP Sino Biological Cell Lysate for TSLP
	ProSpec Recombinant Protein for TSLP
	Cloud-Clone Corp. Proteins for TSLP
	eBioscience Proteins for TSLP: (see all 2) Human TSLP Recombinant Protein 5 ug
	GeneTex Proteins for TSLP: TSLP (Active) recombinant protein (GTX65453)
	antibodies-online proteins for TSLP (34 products)
	antibodies-online peptides for TSLP

TSLP Antibody Products:
EMD Millipore Mono- and Polyclonal Antibodies for the study of TSLP
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OriGene Antibodies for TSLP
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Novus Biologicals TSLP Antibodies
Abcam antibodies for TSLP
Cloud-Clone Corp. Antibodies for TSLP
ThermoFisher Antibodies for TSLP
antibodies-online antibodies for TSLP (126 products)
TSLP Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for TSLP
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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TSLP
Cloud-Clone Corp. CLIAs for TSLP
eBioscience ELISAs for TSLP:
Human TSLP ELISA Ready-SET-Go! Set 2 x 96 tests
antibodies-online kits for TSLP (37 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q969D9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TSLP_HUMAN, Q969D9

Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular,

enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast

cells

Induction: Released by primary epithelial cells in response to certain microbial products, physical injury, or

inflammatory cytokines

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--

Find genes that share ontologies with TSLP About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for TSLP:

Decreased viability with pacli

8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tslp):

digestive/alimentary	growth/size/body	hematopoietic system	homeostasis/metabolism	immune system
integument	mortality/aging	respiratory system

Find genes that share phenotypes with TSLP About GenesLikeMe

Animal Models:
MGI mouse knock-outs for TSLP: Tslp^{tm1(KOMP)Vlcg} Tslp^tm1.2Pcn

genOway: Develop your customized and physiologically relevant rodent model for TSLP

miRNA Products:		miRTarBase miRNAs that target TSLP: hsa-mir-335-5p (MIRT017769)

		Block miRNA regulation of human, mouse, rat TSLP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TSLP (see all 15):
		hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-3653 hsa-miR-3125 hsa-miR-3916 hsa-miR-4275

		SwitchGear 3'UTR luciferase reporter plasmid: TSLP 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TSLP
		Predesigned siRNA for gene silencing in human, mouse, rat TSLP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TSLP

Clone Products:		OriGene clones in human, mouse for TSLP (see all 14) OriGene ORF clones in mouse, rat for TSLP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TSLP (NM_033035)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSLP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSLP

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSLP

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-10267 VF1-12481) for TSLP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

TSLP_HUMAN, Q969D9: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
nucleus	2
endoplasmic reticulum	1
plasma membrane	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--

Find genes that share ontologies with TSLP About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for TSLP About

See pathways by source

Powered
by

SuperPath

Contained pathways About

PEDF Induced Signaling

Cytokine-cytokine receptor interaction

0.43

TSLP Signaling Pathway

TSLP Signaling Pathway

Jak-STAT signaling pathway

Jak-STAT signaling pathway

Find genes that share SuperPaths with TSLP About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for TSLP

TSLP Signaling Pathway

2 Kegg Pathways (Kegg details for TSLP):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway

Pathway & Disease-focused RT² Profiler PCR Array including TSLP:

Allergy & Asthma in human mouse rat

Interactions:

GeneGlobe Interaction Network for TSLP

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

Selected Interacting proteins for TSLP (Q969D9³ ENSP00000339804⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRLF2	Q9HC73³, ENSP00000370979⁴	I2D: score=1 STRING: ENSP00000370979
IL7R	P16871³, ENSP00000306157⁴	I2D: score=1 STRING: ENSP00000306157
STAT3	P40763³, ENSP00000264657⁴	I2D: score=1 STRING: ENSP00000264657
STAT5A	P42229³, ENSP00000341208⁴	I2D: score=1 STRING: ENSP00000341208
IKBKG	Q9Y6K9³, ENSP00000358622⁴	I2D: score=1 STRING: ENSP00000358622

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TSLP

4 Novoseek inferred chemical compound relationships for TSLP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tarc	68	11	15944327 (4), 18684970 (2), 17548604 (1), 19538461 (1) (see all 5)
allergens	54.1	6	19561109 (2), 19557146 (1), 18300366 (1), 20144186 (1)
phosphatidylinositol	1.05	2	17513456 (1), 18975342 (1)
tyrosine	0	5	20144186 (3), 10570284 (2)

Find genes that share compounds with TSLP About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for TSLP gene (2 alternative transcripts):

NM_033035.4 NM_138551.4

Unigene Cluster for TSLP:

Thymic stromal lymphopoietin

Hs.389874 [show with all ESTs]

Unigene Representative Sequence: NR_045089

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000420978(uc003kpa.2) ENST00000344895 ENST00000379706(uc003kpb.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat TSLP using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TSLP (see all 15):
		hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-3653 hsa-miR-3125 hsa-miR-3916 hsa-miR-4275

		SwitchGear 3'UTR luciferase reporter plasmid: TSLP 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TSLP
		Predesigned siRNA for gene silencing in human, mouse, rat TSLP

Clone Products:		OriGene clones in human, mouse for TSLP (see all 14) OriGene ORF clones in mouse, rat for TSLP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TSLP (NM_033035)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSLP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSLP

Primer Products:		OriGene qPCR primer pairs and template standards for TSLP OriGene qSTAR qPCR primer pairs in human, mouse for TSLP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TSLP
		QuantiTect SYBR Green Assays in human, mouse, rat TSLP
		QuantiFast Probe-based Assays in human, mouse, rat TSLP

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-10267 VF1-12481) for TSLP

Additional mRNA sequence:

AF338732.1 AL833421.1 AY037115.1 BC016720.1 BC022894.1 BC040592.1 NR_045089.1

3 DOTS entries:

DT.100021728 DT.100021730 DT.40126313

Selected AceView cDNA sequences (see all 42):

CA443222 NM_138551 AA970358 AA926689 BM969303 NM_033035 BE737833 BG532037

BE738160 BG189131 AL833421 AF338732 BG496490 BE738439 AW118681 AY037115

BX092127 BC040592 CD104390 BC016720 BC022894 BU571002 BF244565 BF219288

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSLP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TSLP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Kidney (Urinary System) fully expand to see all 2 entries
S-shaped Body

Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Muscle Progenitor Cells Mandibular Arch Muscles

Heart (Cardiovascular System)
Mature Cardiac Fibroblasts Myocardium

Fibroblasts
Mature Cardiac Fibroblasts Myocardium

Umbilical Cord (Extraembryonic Tissues)
Wharton's jelly-derived stem cells

TSLP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TSLP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.389874

UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9

Tissue specificity: Expressed in a number of tissues including heart, liver and prostate

Pathway & Disease-focused RT² Profiler PCR Array including TSLP:

Allergy & Asthma in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TSLP OriGene qSTAR qPCR primer pairs in human, mouse for TSLP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TSLP
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		QuantiFast Probe-based Assays in human, mouse, rat TSLP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSLP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TSLP gene from Selected species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tslp^{1 , 5}	thymic stromal lymphopoietin^{1, 5}	61.36(n)¹ 44.7(a)¹		18 (18.12 cM)⁵ 53603¹ NM_021367.2¹ NP_067342.1¹ 32815383⁵

ENSEMBL Gene Tree for TSLP (if available)
TreeFam Gene Tree for TSLP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142608930^1,2		--	110404082(+)	`TATTGC/TCTAAG`	1	--	us2k¹		0	--	--	--	--
rs146023823^1,2		--	110404130(+)	`CTTCTA/GTTTCC`	1	--	us2k¹		0	--	--	--	--
rs17551370^1,2	C,F,H	--	110404185(+)	`ACTACG/ATATGC`	1	--	us2k¹		20		NA NS EA WA	2480
rs11466728^1,2	C,F	--	110404246(+)	`CAGGAA/CGCTTT`	1	--	us2k¹ tfbs³		4		NA EU	96
rs116339898^1,2	C,F	--	110404269(+)	`GAATTT/ATCACA`	1	--	us2k¹		1		WA	118
rs141864668^1,2		--	110404425(+)	`GTTAAA/TATGCT`	1	--	us2k¹		0	--	--	--	--
rs112609463^1,2	F	--	110404485(+)	`CAGCCC/TTATTG`	1	--	us2k¹		1		CSA	2
rs189863742^1,2		--	110404502(+)	`TGATGA/TTGACC`	1	--	us2k¹		0	--	--	--	--
rs149149964^1,2		--	110404611(+)	`CTTTT-/GAG ATCAATTGTT`	1	--	us2k¹		0	--	--	--	--
rs183217210^1,2		--	110404617(+)	`AGATCA/GATTGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TSLP (110405760 - 110413722 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for TSLP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv830447	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): TSLP

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TSLP

DNA2.0 Custom Variant and Variant Library Synthesis for TSLP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 607003 OMIM disorders: --

8 diseases for TSLP:
About MalaCards

eczema herpeticum chronic obstructive pulmonary disease cryoglobulinemia eosinophilic esophagitis

asthma membranoproliferative glomerulonephritis atopy esophagitis

9 inferred disease relationships from the University of Copenhagen DISEASES database for TSLP:

Atopic dermatitis Asthma Hypersensitivity reaction type I disease Allergic rhinitis

Membranoproliferative glomerulonephritis Eosinophilic esophagitis Cryoglobulinemia Eczema herpeticum

Netherton syndrome

Find genes that share disorders with TSLP About GenesLikeMe

Selected Novoseek inferred disease relationships for TSLP gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dermatitis atopic	74.5	33	17666213 (2), 16432252 (2), 19609063 (1), 14501434 (1) (see all 21)
asthma allergic	69.7	13	19539984 (1), 20128689 (1), 18724870 (1), 16899198 (1) (see all 7)
inflammation	60.8	71	18926564 (4), 20143171 (3), 16432252 (3), 17666213 (2) (see all 36)
asthma	59.1	50	18684970 (6), 15944327 (2), 19539984 (2), 19671341 (2) (see all 25)
mixed cryoglobulinemia	55.4	7	11733384 (1), 12631122 (1), 17322382 (1), 15086460 (1)
allergy	53.2	7	19741251 (1), 15741223 (1), 18832690 (1), 14999427 (1) (see all 6)
glomerulonephritis membranoproliferative	50.3	7	12631122 (2), 17686814 (1), 15086460 (1)
dermatitis	49.1	1	14501434 (1)
severe combined immunodeficiency, x-linked	48.3	1	15263024 (1)
cryoglobulinemia	43.9	2	17322382 (1)

Genetic Association Database (GAD): TSLP
Human Genome Epidemiology (HuGE) Navigator: TSLP (15 documents)

Export disorders for TSLP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TSLP gene, integrated from 10 sources (see all 234):
(articles sorted by number of sources associating them with TSLP)

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Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PubMed id 11480573)^{1, 2, 3, 9} Quentmeier H.... Lyman S.D. (Leukemia 2001)
Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PubMed id 11418668)^{1, 2, 3, 9} Reche P.A.... Bazan J.F. (J. Immunol. 2001)
Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo. (PubMed id 19555430)^{1, 4, 9} Cheong K.A....Lee A.Y. (Exp. Dermatol. 2009)
A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. (PubMed id 19539984)^{1, 4, 9} He J.Q....Daley D. (J. Allergy Clin. Immunol. 2009)
Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PubMed id 20208534)^{1, 4, 9} Rothenberg M.E....Hakonarson H. (Nat. Genet. 2010)
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (PubMed id 20466416)^{1, 4, 9} Gao P.S....Barnes K.C. (J. Allergy Clin. Immunol. 2010)
Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. (PubMed id 21085187)^{1, 4} Birlea S.A....Spritz R.A. (J. Invest. Dermatol. 2011)
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. (PubMed id 22036096)^{1, 4} Ramasamy A....Jarvis D.L. (J. Allergy Clin. Immunol. 2011)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
TSLP polymorphisms are associated with asthma in a sex-specific fashion. (PubMed id 20560908)^{1, 4} Hunninghake G.M....CeledA^n J.C. (Allergy 2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85480	HGNC: 30743	AceView: TSLP	Ensembl:ENSG00000145777	euGenes: HUgn85480
ECgene: TSLP	Kegg: 85480	H-InvDB: TSLP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TSLP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TSLP gene
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Selected GeneTex proteins for TSLP: TSLP (Active) recombinant protein (GTX65453)

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TSLP Gene

Thymic Stromal Lymphopoietin

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