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TSLP Gene

protein-coding   GIFtS: 57
GCID: GC05P110405

Thymic Stromal Lymphopoietin

  See TSLP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thymic Stromal Lymphopoietin1 2

External Ids:    HGNC: 307431   Entrez Gene: 854802   Ensembl: ENSG000001457777   OMIM: 6070035   UniProtKB: Q969D93   

Export aliases for TSLP gene to outside databases

Previous GC identifers: GC05P110030 GC05P110853 GC05P110436 GC05P110481 GC05P110433 GC05P110435 GC05P105586


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSLP Gene:
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of
the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces
the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic
cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various
inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The
protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative
splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for TSLP Gene:
TSLP (thymic stromal lymphopoietin) is a protein-coding gene. Diseases associated with TSLP include eosinophilic esophagitis, and eczema herpeticum. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9
Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular,
enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast
cells

Gene Wiki entry for TSLP (Thymic stromal lymphopoietin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSLP gene promoter:
         MEF-2A   STAT1   aMEF-2   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSLP promoter sequence
   Search Chromatin IP Primers for TSLP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSLP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.1   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.1

TSLP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSLP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P110405:  view genomic region     (about GC identifiers)

Start:
110,405,760 bp from pter      End:
110,413,722 bp from pter
Size:
7,963 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TSLP

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9 (See protein sequence)
Recommended Name: Thymic stromal lymphopoietin precursor  
Size: 159 amino acids; 18141 Da
Subunit: Interacts with a receptor composed of CRLF2 and IL7R
Secondary accessions: Q8IW99

Explore the universe of human proteins at neXtProt for TSLP: NX_Q969D9

Explore proteomics data for TSLP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn64, Asn119
  • Modification sites at PhosphoSitePlus

  • See TSLP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_149024.1  NP_612561.2  

    ENSEMBL proteins: 
     ENSP00000399099   ENSP00000339804   ENSP00000427827  

    TSLP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TSLP
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    Novus Biologicals TSLP Lysates
    Sino Biological Recombinant Protein for TSLP
    Sino Biological Cell Lysate for TSLP
    ProSpec Recombinant Protein for TSLP
    Cloud-Clone Corp. Proteins for TSLP

     
    eBioscience Proteins for TSLP: (see all 2
                        Human TSLP Recombinant Protein 5 ug

    TSLP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TSLP
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    TSLP Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSLP
    Cloud-Clone Corp. CLIAs for TSLP
    eBioscience ELISAs for TSLP:  
                        Human TSLP ELISA Ready-SET-Go! Set 2 x 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q969D9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSLP_HUMAN, Q969D9
    Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular,
    enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast
    cells
    Induction: Released by primary epithelial cells in response to certain microbial products, physical injury, or
    inflammatory cytokines

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    Find genes that share ontologies with TSLP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TSLP:
     Decreased viability with pacli 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tslp):
     digestive/alimentary  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  respiratory system 

    Find genes that share phenotypes with TSLP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TSLP: Tslptm1(KOMP)Vlcg Tslptm1.2Pcn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSLP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSLP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSLP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSLP

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSLP:
    hsa-mir-335-5p (MIRT017769)

    Block miRNA regulation of human, mouse, rat TSLP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSLP (see all 15):
    hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-3653 hsa-miR-3125 hsa-miR-3916 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidTSLP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSLP
    Predesigned siRNA for gene silencing in human, mouse, rat TSLP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TSLP

    Clone
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    OriGene clones in human, mouse for TSLP (see all 14)
    OriGene ORF clones in mouse, rat for TSLP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSLP (NM_033035)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSLP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSLP

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10267 VF1-12481) for TSLP 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSLP_HUMAN, Q969D9: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with TSLP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSLP About    
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    2TSLP Signaling Pathway
    TSLP Signaling Pathway
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway


    Find genes that share SuperPaths with TSLP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TSLP
        TSLP Signaling Pathway



    2 Kegg Pathways  (Kegg details for TSLP):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including TSLP: 
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TSLP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for TSLP (Q969D93 ENSP000003398044) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRLF2Q9HC733, ENSP000003709794I2D: score=1 STRING: ENSP00000370979
    IL7RP168713, ENSP000003061574I2D: score=1 STRING: ENSP00000306157
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    STAT5AP422293, ENSP000003412084I2D: score=1 STRING: ENSP00000341208
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSLP

    4 Novoseek inferred chemical compound relationships for TSLP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 68 11 15944327 (4), 18684970 (2), 17548604 (1), 19538461 (1) (see all 5)
    allergens 54.1 6 19561109 (2), 19557146 (1), 18300366 (1), 20144186 (1)
    phosphatidylinositol 1.05 2 17513456 (1), 18975342 (1)
    tyrosine 0 5 20144186 (3), 10570284 (2)



    Find genes that share compounds with TSLP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSLP gene (2 alternative transcripts): 
    NM_033035.4  NM_138551.4  

    Unigene Cluster for TSLP:

    Thymic stromal lymphopoietin
    Hs.389874  [show with all ESTs]
    Unigene Representative Sequence: NR_045089
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420978(uc003kpa.2) ENST00000344895 ENST00000379706(uc003kpb.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSLP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSLP (see all 15):
    hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-3653 hsa-miR-3125 hsa-miR-3916 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidTSLP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSLP
    Predesigned siRNA for gene silencing in human, mouse, rat TSLP
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSLP (NM_033035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSLP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSLP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSLP
    OriGene qSTAR qPCR primer pairs in human, mouse for TSLP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSLP
      QuantiTect SYBR Green Assays in human, mouse, rat TSLP
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10267 VF1-12481) for TSLP 

    Additional mRNA sequence: 

    AF338732.1 AL833421.1 AY037115.1 BC016720.1 BC022894.1 BC040592.1 NR_045089.1 

    3 DOTS entries:

    DT.100021728  DT.100021730  DT.40126313 

    Selected AceView cDNA sequences (see all 42):

    CA443222 NM_138551 AA970358 AA926689 BM969303 NM_033035 BE737833 BG532037 
    BE738160 BG189131 AL833421 AF338732 BG496490 BE738439 AW118681 AY037115 
    BX092127 BC040592 CD104390 BC016720 BC022894 BU571002 BF244565 BF219288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSLP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSLP Expression
    About this image


    TSLP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
    TSLP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSLP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.389874

    UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9
    Tissue specificity: Expressed in a number of tissues including heart, liver and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including TSLP: 
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSLP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TSLP gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tslp1 , 5 thymic stromal lymphopoietin1, 5 61.36(n)1
    44.7(a)1
      18 (18.12 cM)5
    536031  NM_021367.21  NP_067342.11 
     328153835 


    ENSEMBL Gene Tree for TSLP (if available)
    TreeFam Gene Tree for TSLP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSLP (see all 252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426089301,2
    --110404082(+) TATTGC/TCTAAG 1 -- us2k10--------
    rs1460238231,2
    --110404130(+) CTTCTA/GTTTCC 1 -- us2k10--------
    rs175513701,2
    C,F,H--110404185(+) ACTACG/ATATGC 1 -- us2k120Minor allele frequency- A:0.12NA NS EA WA 2480
    rs114667281,2
    C,F--110404246(+) CAGGAA/CGCTTT 1 -- us2k1 tfbs34Minor allele frequency- C:0.03NA EU 96
    rs1163398981,2
    C,F--110404269(+) GAATTT/ATCACA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1418646681,2
    --110404425(+) GTTAAA/TATGCT 1 -- us2k10--------
    rs1126094631,2
    F--110404485(+) CAGCCC/TTATTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1898637421,2
    --110404502(+) TGATGA/TTGACC 1 -- us2k10--------
    rs1491499641,2
    --110404611(+) CTTTT-/GAG   
       ATCAA
    TTGTT
    1 -- us2k10--------
    rs1832172101,2
    --110404617(+) AGATCA/GATTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSLP (110405760 - 110413722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TSLP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830447CNV Loss17160897

    Human Gene Mutation Database (HGMD): TSLP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSLP
    DNA2.0 Custom Variant and Variant Library Synthesis for TSLP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607003    OMIM disorders: --

    7 diseases for TSLP:    
    About MalaCards
    eosinophilic esophagitis    eczema herpeticum    cryoglobulinemia    membranoproliferative glomerulonephritis
    esophagitis    atopy    asthma

    9 diseases from the University of Copenhagen DISEASES database for TSLP:
    Atopic dermatitis     Asthma     Hypersensitivity reaction type I disease     Allergic rhinitis
    Membranoproliferative glomerulonephritis     Eosinophilic esophagitis     Cryoglobulinemia     Eczema herpeticum
    Netherton syndrome

    Find genes that share disorders with TSLP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TSLP gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis atopic 74.5 33 17666213 (2), 16432252 (2), 19609063 (1), 14501434 (1) (see all 21)
    asthma allergic 69.7 13 19539984 (1), 20128689 (1), 18724870 (1), 16899198 (1) (see all 7)
    inflammation 60.8 71 18926564 (4), 20143171 (3), 16432252 (3), 17666213 (2) (see all 36)
    asthma 59.1 50 18684970 (6), 15944327 (2), 19539984 (2), 19671341 (2) (see all 25)
    mixed cryoglobulinemia 55.4 7 11733384 (1), 12631122 (1), 17322382 (1), 15086460 (1)
    allergy 53.2 7 19741251 (1), 15741223 (1), 18832690 (1), 14999427 (1) (see all 6)
    glomerulonephritis membranoproliferative 50.3 7 12631122 (2), 17686814 (1), 15086460 (1)
    dermatitis 49.1 1 14501434 (1)
    severe combined immunodeficiency, x-linked 48.3 1 15263024 (1)
    cryoglobulinemia 43.9 2 17322382 (1)

    Genetic Association Database (GAD): TSLP
    Human Genome Epidemiology (HuGE) Navigator: TSLP (15 documents)

    Export disorders for TSLP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSLP gene, integrated from 10 sources (see all 234):
    (articles sorted by number of sources associating them with TSLP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PubMed id 11480573)1, 2, 3, 9 Quentmeier H.... Lyman S.D. (Leukemia 2001)
    2. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PubMed id 11418668)1, 2, 3, 9 Reche P.A.... Bazan J.F. (J. Immunol. 2001)
    3. Association of thymic stromal lymphopoietin gene -847C&gt;T polymorphism in generalized vitiligo. (PubMed id 19555430)1, 4, 9 Cheong K.A....Lee A.Y. (Exp. Dermatol. 2009)
    4. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. (PubMed id 19539984)1, 4, 9 He J.Q....Daley D. (J. Allergy Clin. Immunol. 2009)
    5. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PubMed id 20208534)1, 4, 9 Rothenberg M.E....Hakonarson H. (Nat. Genet. 2010)
    6. Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (PubMed id 20466416)1, 4, 9 Gao P.S....Barnes K.C. (J. Allergy Clin. Immunol. 2010)
    7. Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. (PubMed id 21085187)1, 4 Birlea S.A....Spritz R.A. (J. Invest. Dermatol. 2011)
    8. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. (PubMed id 22036096)1, 4 Ramasamy A....Jarvis D.L. (J. Allergy Clin. Immunol. 2011)
    9. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    10. TSLP polymorphisms are associated with asthma in a sex-specific fashion. (PubMed id 20560908)1, 4 Hunninghake G.M....CeledA^n J.C. (Allergy 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85480 HGNC: 30743 AceView: TSLP Ensembl:ENSG00000145777 euGenes: HUgn85480
    ECgene: TSLP Kegg: 85480 H-InvDB: TSLP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSLP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSLP gene:
    Search GeneIP for patents involving TSLP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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