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Aliases for TSLP Gene

Aliases for TSLP Gene

  • Thymic Stromal Lymphopoietin 2 3

External Ids for TSLP Gene

Summaries for TSLP Gene

Entrez Gene Summary for TSLP Gene

  • This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for TSLP Gene

TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include eczema herpeticum and cryoglobulinemia. Among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for TSLP Gene

  • Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

  • Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.

Gene Wiki entry for TSLP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSLP Gene

Genomics for TSLP Gene

Genomic Location for TSLP Gene

Start:
111,070,062 bp from pter
End:
111,078,024 bp from pter
Size:
7,963 bases
Orientation:
Plus strand

Genomic View for TSLP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSLP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSLP Gene

Regulatory Elements for TSLP Gene

Proteins for TSLP Gene

  • Protein details for TSLP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969D9-TSLP_HUMAN
    Recommended name:
    Thymic stromal lymphopoietin
    Protein Accession:
    Q969D9
    Secondary Accessions:
    • G3XAM8
    • Q8IW99
    • Q96AU7

    Protein attributes for TSLP Gene

    Size:
    159 amino acids
    Molecular mass:
    18141 Da
    Quaternary structure:
    • Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
    SequenceCaution:
    • Sequence=AAH16720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TSLP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSLP Gene

Proteomics data for TSLP Gene at MOPED

Post-translational modifications for TSLP Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn64 and Asn119

Other Protein References for TSLP Gene

No data available for DME Specific Peptides for TSLP Gene

Domains for TSLP Gene

Protein Domains for TSLP Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TSLP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TSLP Gene

Function for TSLP Gene

Molecular function for TSLP Gene

UniProtKB/Swiss-Prot Function: Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
UniProtKB/Swiss-Prot Function: Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
UniProtKB/Swiss-Prot Induction: Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.

Gene Ontology (GO) - Molecular Function for TSLP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with TSLP: view
genes like me logo Genes that share phenotypes with TSLP: view

Animal Models for TSLP Gene

MGI Knock Outs for TSLP:

miRNA for TSLP Gene

miRTarBase miRNAs that target TSLP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TSLP Gene

Localization for TSLP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSLP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSLP Gene COMPARTMENTS Subcellular localization image for TSLP gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TSLP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with TSLP: view

Pathways for TSLP Gene

genes like me logo Genes that share pathways with TSLP: view

Pathways by source for TSLP Gene

1 BioSystems pathway for TSLP Gene

Gene Ontology (GO) - Biological Process for TSLP Gene

None

Compounds for TSLP Gene

(4) Novoseek inferred chemical compound relationships for TSLP Gene

Compound -log(P) Hits PubMed IDs
tarc 68 9
allergens 54.1 5
phosphatidylinositol 1.05 2
tyrosine 0 5
genes like me logo Genes that share compounds with TSLP: view

Transcripts for TSLP Gene

Unigene Clusters for TSLP Gene

Thymic stromal lymphopoietin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSLP Gene

No ASD Table

Relevant External Links for TSLP Gene

GeneLoc Exon Structure for
TSLP
ECgene alternative splicing isoforms for
TSLP

Expression for TSLP Gene

mRNA expression in normal human tissues for TSLP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSLP Gene

This gene is overexpressed in Liver (4.4) and Heart - Left Ventricle (4.0).

SOURCE GeneReport for Unigene cluster for TSLP Gene Hs.389874

mRNA Expression by UniProt/SwissProt for TSLP Gene

Q969D9-TSLP_HUMAN
Tissue specificity: Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.
genes like me logo Genes that share expressions with TSLP: view

Orthologs for TSLP Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSLP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSLP 36
  • 99.79 (n)
  • 99.37 (a)
TSLP 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC617637 36
  • 67.14 (n)
  • 56.34 (a)
dog
(Canis familiaris)
Mammalia TSLP 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tslp 36
  • 61.36 (n)
  • 44.7 (a)
Tslp 16
Tslp 37
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tslp 36
  • 65.92 (n)
  • 50 (a)
Species with no ortholog for TSLP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSLP Gene

ENSEMBL:
Gene Tree for TSLP (if available)
TreeFam:
Gene Tree for TSLP (if available)

Paralogs for TSLP Gene

No data available for Paralogs for TSLP Gene

Variants for TSLP Gene

Sequence variations from dbSNP and Humsavar for TSLP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1898671 -- 111,072,304(+) TTATG(C/T)GTCAA intron-variant, upstream-variant-2KB
rs2289276 -- 111,071,809(+) TGGCC(C/T)CTAAG utr-variant-5-prime, upstream-variant-2KB, intron-variant
rs2289277 -- 111,073,369(+) CAACC(A/C/G)TGACC intron-variant, utr-variant-5-prime
rs2289278 -- 111,073,450(+) TCTCA(C/G)CAACT intron-variant, utr-variant-5-prime
rs3806932 -- 111,069,977(+) CCTAT(A/G)TAATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSLP Gene

Variant ID Type Subtype PubMed ID
nsv830447 CNV Loss 17160897

Relevant External Links for TSLP Gene

HapMap Linkage Disequilibrium report
TSLP
Human Gene Mutation Database (HGMD)
TSLP

Disorders for TSLP Gene

(16) Novoseek inferred disease relationships for TSLP Gene

Disease -log(P) Hits PubMed IDs
dermatitis atopic 74.5 23
asthma allergic 69.7 7
inflammation 60.8 49
asthma 59.1 36
mixed cryoglobulinemia 55.4 4

Relevant External Links for TSLP

Genetic Association Database (GAD)
TSLP
Human Genome Epidemiology (HuGE) Navigator
TSLP
genes like me logo Genes that share disorders with TSLP: view

No data available for UniProtKB/Swiss-Prot for TSLP Gene

Publications for TSLP Gene

  1. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PMID: 11418668) Reche P.A. … Bazan J.F. (J. Immunol. 2001) 2 3 4 23
  2. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PMID: 11480573) Quentmeier H. … Lyman S.D. (Leukemia 2001) 2 3 4 23
  3. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. (PMID: 19539984) He J.Q. … Daley D. (J. Allergy Clin. Immunol. 2009) 3 23 49
  4. Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo. (PMID: 19555430) Cheong K.A. … Lee A.Y. (Exp. Dermatol. 2009) 3 23 49
  5. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PMID: 20208534) Rothenberg M.E. … Hakonarson H. (Nat. Genet. 2010) 3 23 49

Products for TSLP Gene

Sources for TSLP Gene

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