Aliases for TSLP Gene
External Ids for TSLP Gene
- HGNC: 30743
- Entrez Gene: 85480
- Ensembl: ENSG00000145777
- OMIM: 607003
- UniProtKB: Q969D9
Previous GeneCards Identifiers for TSLP Gene
- GC05P110030
- GC05P110853
- GC05P110436
- GC05P110481
- GC05P110433
- GC05P110435
- GC05P110405
- GC05P105586
Summaries for TSLP Gene
-
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for TSLP Gene
TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Cryoglobulinemic Vasculitis and Eczema Herpeticum. Among its related pathways are Jak-STAT signaling pathway and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity.
UniProtKB/Swiss-Prot for TSLP Gene
-
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
-
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSLP Gene
Genomics for TSLP Gene
Regulatory Elements for TSLP Gene
Enhancers for TSLP Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TSLP on UCSC Golden Path with GeneCards custom track
Promoters for TSLP Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TSLP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TSLP gene promoter:
Regulatory Element Products
Genomic Location for TSLP Gene
- Chromosome:
- 5
- Start:
- 111,070,062 bp from pter
- End:
- 111,078,024 bp from pter
- Size:
- 7,963 bases
- Orientation:
- Plus strand
Genomic View for TSLP Gene
Genes around TSLP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q22.1 by Ensembl
- 5q22.1 by Entrez Gene
- 5q22.1 by HGNC
TSLP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TSLP Gene
Proteins for TSLP Gene
-
Protein details for TSLP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969D9-TSLP_HUMAN
- Recommended name:
- Thymic stromal lymphopoietin
- Protein Accession:
- Q969D9
- G3XAM8
- Q8IW99
- Q96AU7
Protein attributes for TSLP Gene
- Size:
- 159 amino acids
- Molecular mass:
- 18141 Da
- Quaternary structure:
-
- Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
- SequenceCaution:
-
- Sequence=AAH16720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for TSLP Gene
Other Protein References for TSLP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for TSLP
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- Abcam antibodies for TSLP
-
Cloud-Clone Corp. Antibodies for TSLP
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- antibodies-online Antibodies for TSLP: See all 139
- GeneTex TSLP antibody for TSLP
-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for TSLP
Protein Products
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-
Cloud-Clone Corp. Proteins for TSLP
- eBioscience Human TSLP Recombinant Protein 5 ug for TSLP
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- antibodies-online Proteins for TSLP: See all 61
- Search antibodies-online for peptides
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Assay Products
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- antibodies-online Kits for TSLP: See all 80
- Abcam assays for TSLP
No data available for DME Specific Peptides for TSLP Gene
Domains & Families for TSLP Gene
Suggested Antigen Peptide Sequences for TSLP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for TSLP Gene
Function for TSLP Gene
Molecular function for TSLP Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
- UniProtKB/Swiss-Prot Function:
- Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
- UniProtKB/Swiss-Prot Induction:
- Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.
Phenotypes for TSLP Gene
- MGI mutant phenotypes for TSLP:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for TSLP:
Animal Models for TSLP Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for TSLP
-
ViGene Biosciences lentiviral particle packaged cDNA for TSLP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TSLP gene
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CRISPR Products
-
OriGene CRISPR knockouts for TSLP
-
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miRNA for TSLP Gene
- miRTarBase miRNAs that target TSLP
-
- hsa-mir-335-5p (MIRT017769)
- hsa-mir-299-5p (MIRT527977)
- hsa-mir-5699-5p (MIRT527978)
- hsa-mir-4518 (MIRT527979)
- hsa-mir-1266-5p (MIRT527980)
- hsa-mir-6793-3p (MIRT527981)
- hsa-mir-6754-5p (MIRT527982)
- hsa-mir-4441 (MIRT527983)
- hsa-mir-4270 (MIRT527984)
- hsa-mir-211-3p (MIRT527985)
- hsa-mir-6769a-3p (MIRT527986)
- hsa-mir-3943 (MIRT527987)
- hsa-mir-4323 (MIRT527988)
- hsa-mir-6732-3p (MIRT527989)
- hsa-mir-652-5p (MIRT527990)
miRNA Products
- Search ViGene Biosciences for TSLP
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for TSLP
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-
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Clone Products
- OriGene clones in human for TSLP
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Cell Line Products
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ViGene Biosciences adenoviral particle packaged cDNA for TSLP gene
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Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10267 VF1-12481 ) for TSLP
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSLP Gene
Localization for TSLP Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSLP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 2 |
| cytosol | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| plasma membrane | 1 |
No data available for Gene Ontology (GO) - Cellular Components for TSLP Gene
Pathways & Interactions for TSLP Gene
More details on SuperPathways for TSLP| Superpath | Contained pathways | |
|---|---|---|
| 1 | PEDF Induced Signaling | |
| 2 | Jak-STAT signaling pathway | |
| 3 | Innate Lymphoid Cell Differentiation Pathways | |
| 4 | TSLP Signaling Pathway |
Pathways by source for TSLP Gene
1 BioSystems pathway for TSLP Gene
2 KEGG pathways for TSLP Gene
1 R&D Systems pathway for TSLP Gene
Transcripts for TSLP Gene
mRNA/cDNA for TSLP Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TSLP Gene
CRISPR Products
-
OriGene CRISPR knockouts for TSLP
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSLP
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miRNA Products
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Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for TSLP
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-
ViGene Biosciences ready-to-package AAV shRNAs for TSLP gene
Clone Products
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Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10267 VF1-12481 ) for TSLP
Expression for TSLP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Kidney (Urinary System)
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for TSLP Gene
This gene is overexpressed in Liver (x4.4) and Heart - Left Ventricle (x4.0).
SOURCE GeneReport for Unigene cluster for TSLP Gene Hs.389874
mRNA Expression by UniProt/SwissProt for TSLP Gene
Q969D9-TSLP_HUMAN
Tissue specificity:
Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.
Primer Products
-
OriGene qPCR primer pairs for TSLP
-
OriGene qPCR primer pairs and template standards for TSLP
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TSLP Gene
Orthologs for TSLP Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LOC617637 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Tslp 35 |
|
||
| Tslp 16 |
|
||||
| Tslp 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TSLP 35 |
|
||
| TSLP 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Tslp 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TSLP 36 |
|
OneToOne |
- Species with no ortholog for TSLP:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TSLP Gene
No data available for Paralogs for TSLP Gene
Variants for TSLP Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs6864123 | -- | 111,077,435(+) | TGTCC(A/G)GAGAA | nc-transcript-variant, utr-variant-3-prime | |
| rs3806932 | -- | 111,069,977(+) | CCTAT(A/G)TAATA | upstream-variant-2KB | |
| rs3806933 | -- | 111,071,044(+) | CCTAG(C/T)CACCA | nc-transcript-variant, upstream-variant-2KB | |
| rs1898671 | -- | 111,072,304(+) | TTATG(C/T)GTCAA | intron-variant, upstream-variant-2KB | |
| rs10455025 | -- | 111,069,301(+) | TGGCA(A/C)GACAT | upstream-variant-2KB |
Residual Variation Intolerance Score:
22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TSLP Gene
- Human Gene Mutation Database (HGMD)
- TSLP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSLP Gene
Disorders for TSLP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cryoglobulinemic vasculitis |
|
|
| eczema herpeticum |
|
|
| cryoglobulinemia |
|
|
| allergic asthma |
|
|
| membranoproliferative glomerulonephritis |
|
Search TSLP in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TSLP
No data available for UniProtKB/Swiss-Prot and Genatlas for TSLP Gene
Publications for TSLP Gene
- Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PMID: 11480573) Quentmeier H. … Lyman S.D. (Leukemia 2001) 2 3 4 23 67
- Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PMID: 11418668) Reche P.A. … Bazan J.F. (J. Immunol. 2001) 2 3 23
- Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis. (PMID: 19741251) Matsuda A. … Murakami A. (Invest. Ophthalmol. Vis. Sci. 2010) 3 23
- Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses. (PMID: 19841072) Kido M. … Watanabe N. (Infect. Immun. 2010) 3 23
- Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. (PMID: 19968632) Xu G. … Li H.B. (Allergy 2010) 3 23
Products for TSLP Gene
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- antibodies-online Antibodies for TSLP: See all 139
- antibodies-online Kits for TSLP: See all 80
- antibodies-online Proteins for TSLP: See all 61
- Search antibodies-online for peptides
- GeneTex TSLP antibody for TSLP
- GeneTex TSLP Recombinant Protein (GTX48249-PRO) for TSLP
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- ViGene Biosciences adenoviral particle packaged cDNA for TSLP gene
- ViGene Biosciences lentiviral particle packaged cDNA for TSLP gene
- ViGene Biosciences lentiviral particle packaged cDNA for TSLP gene
- ViGene Biosciences ready-to-package AAV shRNAs for TSLP gene
- ViGene Biosciences ready-to-package AAV shRNAs for TSLP gene
- ViGene Biosciences ready-to-package AAV shRNAs for TSLP gene
- Search ViGene Biosciences for TSLP
- Search ViGene Biosciences for TSLP
- Santa Cruz Biotechnology (SCBT) Antibodies for TSLP
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- Custom Antibody ServicesProSci Antibodies for TSLP
Sources for TSLP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon