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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSLP Gene

protein-coding   GIFtS: 57
GCID: GC05P110405

Thymic Stromal Lymphopoietin
Microbiology & Infectious Diseases Congress
  31 related diseases
at
MalaCards
 

Aliases
for TSLP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Thymic Stromal Lymphopoietin1 2

External Ids:    HGNC: 307431   Entrez Gene: 854802   Ensembl: ENSG000001457777   OMIM: 6070035   UniProtKB: Q969D93   
ORGUL members:         
NONCODE14:n409258 n411753      

Export aliases for TSLP gene to outside databases

Previous GC identifers: GC05P110030 GC05P110853 GC05P110436 GC05P110481 GC05P110433 GC05P110435 GC05P105586


Summaries
for TSLP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TSLP Gene:
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the
thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the
release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The
protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory
diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore
considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene
results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for TSLP Gene: 
TSLP (thymic stromal lymphopoietin) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TSLP include chronic obstructive pulmonary disease, and cryoglobulinemia, and among its related super-pathways are STAT3 Pathway. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9
Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances
the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells

Gene Wiki entry for TSLP (Thymic stromal lymphopoietin) Gene


Genomic Views
for TSLP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSLP gene promoter:
         MEF-2A   STAT1   aMEF-2   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSLP promoter sequence
   Search SABiosciences Chromatin IP Primers for TSLP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSLP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.1   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.1

TSLP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSLP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P110405:  view genomic region     (about GC identifiers)

Start:
 110,405,760 bp from pter      End:
 110,413,722 bp from pter
Size:
 7,963 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TSLP

Proteins
for TSLP gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9 (See protein sequence)
Recommended Name: Thymic stromal lymphopoietin precursor  
Size: 159 amino acids; 18141 Da
Subunit: Interacts with a receptor composed of CRLF2 and IL7R
Subcellular location: Secreted
Secondary accessions: Q8IW99

Explore the universe of human proteins at neXtProt for TSLP: NX_Q969D9

Explore proteomics data for TSLP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969D9

    • TSLP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSLP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_149024.1  NP_612561.2  

    ENSEMBL proteins: 
     ENSP00000399099   ENSP00000339804   ENSP00000427827  

    Human Recombinant Protein Products for TSLP: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TSLP
    OriGene Custom MassSpec 
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    GenScript Purified and Recombinant Proteins for TSLP
    Novus Biologicals TSLP Proteins
    Novus Biologicals TSLP Lysates
    Sino Biological Recombinant Protein for TSLP
    Sino Biological Cell Lysate for TSLP 
    ProSpec Recombinant Protein for TSLP
    Cloud-Clone Corp. Proteins for TSLP 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    TSLP for ontologies           About GeneDecksing



    TSLP Antibody Products: 
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    Abcam antibodies for TSLP
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    ThermoFisher Antibodies for TSLP
    LSBio Antibodies in human, mouse, rat for TSLP 

    Assay Products for TSLP: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSLP 
    Cloud-Clone Corp. CLIAs for TSLP

    Protein Domains /
    Families
    for TSLP gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q969D9


    Function
    for TSLP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSLP_HUMAN, Q969D9
    Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances
    the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells
    Induction: Released by primary epithelial cells in response to certain microbial products, physical injury, or
    inflammatory cytokines

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    TSLP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSLP:
     Decreased viability with pacli 

         9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tslp):
     cellular  digestive/alimentary  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  respiratory system 

    TSLP for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for TSLP: Tslptm1(KOMP)Vlcg Tslptm1.2Pcn
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSLP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSLP

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSLP
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TSLP (see all 15):
    hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-3653 hsa-miR-3125 hsa-miR-3916 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: TSLP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSLP
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TSLP

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TSLP
                         Customized adenovirus for potent knockdown of TSLP

    Clone
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    OriGene clones in human, mouse for TSLP (see all 15)
    OriGene ORF clones in mouse, rat for TSLP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSLP (NM_033035)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSLP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSLP

    Cell Line
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                         Customized inducible knockdown cell line services for TSLP
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                         Customized inducible overexpressing cell line services for TSLP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSLP


    Pathways & Interactions
    for TSLP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TSLP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    		Cytokine-cytokine receptor interaction0.43
    2TSLP Signaling Pathway
    		TSLP Signaling Pathway
    3Jak-STAT signaling pathway
    		Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TSLP
        TSLP Signaling Pathway



    2         Kegg Pathways  (Kegg details for TSLP):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    TSLP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSLP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for TSLP (Q969D93 ENSP000003398044) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRLF2Q9HC733, ENSP000003709794I2D: score=1 STRING: ENSP00000370979
    IL7RP168713, ENSP000003061574I2D: score=1 STRING: ENSP00000306157
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    STAT5AP422293, ENSP000003412084I2D: score=1 STRING: ENSP00000341208
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    About this table

    Drugs & Compounds
    for TSLP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TSLP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSLP

    4 Novoseek inferred chemical compound relationships for TSLP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 68 11 15944327 (4), 18684970 (2), 17548604 (1), 19538461 (1) (see all 5)
    allergens 54.1 6 19561109 (2), 19557146 (1), 18300366 (1), 20144186 (1)
    phosphatidylinositol 1.05 2 17513456 (1), 18975342 (1)
    tyrosine 0 5 20144186 (3), 10570284 (2)

    Search CenterWatch for drugs/clinical trials and news about TSLP

    Transcripts
    for TSLP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSLP gene (2 alternative transcripts): 
    NM_033035.4  NM_138551.4  

    Unigene Cluster for TSLP:

    Thymic stromal lymphopoietin
    Hs.389874  [show with all ESTs]
    Unigene Representative Sequence: NR_045089
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420978(uc003kpa.2) ENST00000344895 ENST00000379706(uc003kpb.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSLP
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TSLP (see all 15):
    hsa-miR-495 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-3653 hsa-miR-3125 hsa-miR-3916 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: TSLP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSLP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSLP
    Sirion Biotech Custom design and validation of potent shRNA sequences against TSLP
    Clone
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    OriGene ORF clones in mouse, rat for TSLP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSLP (NM_033035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSLP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSLP
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for TSLP
    OriGene qSTAR qPCR primer pairs in human, mouse for TSLP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSLP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSLP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSLP

    Additional mRNA sequence: 

    AF338732.1 AL833421.1 AY037115.1 BC016720.1 BC022894.1 BC040592.1 NR_045089.1 

    3 DOTS entries:

    DT.100021728  DT.100021730  DT.40126313 

    24/42 AceView cDNA sequences (see all 42):

    AA970358 NM_033035 BM969303 CA443222 BE737833 NM_138551 AA926689 BU571002 
    AY037115 BE738439 BX092127 BG189131 CD104390 BG532037 BG496490 AL833421 
    BC016720 AF338732 BC040592 BC022894 BE738160 AW118681 BG776184 BI462392 

    GeneLoc Exon Structure


    Expression
    for TSLP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSLP expression in normal human tissues (normalized intensities)      TSLP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSLP Expression
    About this image


    TSLP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Kidney (Urinary System)
             S-shaped Body

    See TSLP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSLP

    SOURCE GeneReport for Unigene cluster: Hs.389874

    UniProtKB/Swiss-Prot: TSLP_HUMAN, Q969D9
    Tissue specificity: Expressed in a number of tissues including heart, liver and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including TSLP: 
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSLP

    Orthologs
    for TSLP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for TSLP gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tslp1 , 5 thymic stromal lymphopoietin1, 5 61.36(n)1
    44.7(a)1    		   18 (18.12 cM)5
    536031  NM_021367.21  NP_067342.11 
     328153835 


    ENSEMBL Gene Tree for TSLP (if available)
    TreeFam Gene Tree for TSLP (if available)

    Paralogs
    for TSLP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TSLP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/252 SNPs in TSLP are shown (see all 252)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1426089301,2
    		--110404082(+) TATTGC/TCTAAG 1 -- us2k10--------
    rs1460238231,2
    		--110404130(+) CTTCTA/GTTTCC 1 -- us2k10--------
    rs175513701,2
    		C,F,H--110404185(+) ACTACG/ATATGC 1 -- us2k120Minor allele frequency- A:0.12NA NS EA WA 2480
    rs114667281,2
    		C,F--110404246(+) CAGGAA/CGCTTT 1 -- us2k1 tfbs34Minor allele frequency- C:0.03NA EU 96
    rs1163398981,2
    		C,F--110404269(+) GAATTT/ATCACA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1418646681,2
    		--110404425(+) GTTAAA/TATGCT 1 -- us2k10--------
    rs1126094631,2
    		F--110404485(+) CAGCCC/TTATTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1898637421,2
    		--110404502(+) TGATGA/TTGACC 1 -- us2k10--------
    rs1491499641,2
    		--110404611(+) CTTTT-/GAG   
       ATCAA    TTGTT     		1 -- us2k10--------
    rs1832172101,2
    		--110404617(+) AGATCA/GATTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSLP (110405760 - 110413722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TSLP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830447CNV Loss17160897


    Human Gene Mutation Database (HGMD): TSLP
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSLP
    DNA2.0 Custom Variant and Variant Library Synthesis for TSLP

    Disorders / Diseases
    for TSLP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TSLP for disorders           About GeneDecksing

    OMIM gene information: 607003    OMIM disorders: --

    20/31 diseases for TSLP (see all 31):    About MalaCards
    chronic obstructive pulmonary disease    cryoglobulinemia    eczema herpeticum    membranoproliferative glomerulonephritis
    eczema    eosinophilic esophagitis    netherton syndrome    asthma
    atopy    glomerulonephritis    atopic dermatitis    severe combined immunodeficiency
    vitiligo    dermatitis    rabies    keratoconjunctivitis
    allergic rhinitis    rhinitis    meningioma    liver disease

    9 diseases from the University of Copenhagen DISEASES database for TSLP:
    Atopic dermatitis     Asthma     Hypersensitivity reaction type I disease     Allergic rhinitis
    Membranoproliferative glomerulonephritis     Eosinophilic esophagitis     Cryoglobulinemia     Eczema herpeticum
    Netherton syndrome

    10/16 Novoseek inferred disease relationships for TSLP gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis atopic 74.5 33 17666213 (2), 16432252 (2), 19609063 (1), 14501434 (1) (see all 21)
    asthma allergic 69.7 13 19539984 (1), 20128689 (1), 18724870 (1), 16899198 (1) (see all 7)
    inflammation 60.8 71 18926564 (4), 20143171 (3), 16432252 (3), 17666213 (2) (see all 36)
    asthma 59.1 50 18684970 (6), 15944327 (2), 19539984 (2), 19671341 (2) (see all 25)
    mixed cryoglobulinemia 55.4 7 11733384 (1), 12631122 (1), 17322382 (1), 15086460 (1)
    allergy 53.2 7 19741251 (1), 15741223 (1), 18832690 (1), 14999427 (1) (see all 6)
    glomerulonephritis membranoproliferative 50.3 7 12631122 (2), 17686814 (1), 15086460 (1)
    dermatitis 49.1 1 14501434 (1)
    severe combined immunodeficiency, x-linked 48.3 1 15263024 (1)
    cryoglobulinemia 43.9 2 17322382 (1)

    Genetic Association Database (GAD): TSLP
    Human Genome Epidemiology (HuGE) Navigator: TSLP (15 documents)

    Export disorders for TSLP gene to outside databases

    Publications
    for TSLP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSLP gene, integrated from 9 sources (see all 226):
    (articles sorted by number of sources associating them with TSLP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PubMed id 11480573)1, 2, 3, 9 Quentmeier H.... Lyman S.D. (2001)
    2. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PubMed id 11418668)1, 2, 3, 9 Reche P.A.... Bazan J.F. (2001)
    3. Association of thymic stromal lymphopoietin gene -847 C>T polymorphism in generalized vitiligo. (PubMed id 19555430)1, 4, 9 Cheong K.A....Lee A.Y. (2009)
    4. A thymic stromal lymphopoietin gene variant is associ ated with asthma and airway hyperresponsiveness. (PubMed id 19539984)1, 4, 9 He J.Q....Daley D. (2009)
    5. Common variants at 5q22 associate with pediatric eosi nophilic esophagitis. (PubMed id 20208534)1, 4, 9 Rothenberg M.E....Hakonarson H. (2010)
    6. Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (PubMed id 20466416)1, 4, 9 Gao P.S....Barnes K.C. (2010)
    7. A genome-wide meta-analysis of genetic variants associ ated with allergic rhinitis and grass sensitization and their interaction with b irth order. (PubMed id 22036096)1, 4 Ramasamy A....Jarvis D.L. (2011)
    8. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    9. TSLP polymorphisms are associated with asthma in a se x-specific fashion. (PubMed id 20560908)1, 4 Hunninghake G.M....CeledA^n J.C. (2010)
    10. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)

    External Searches for TSLP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing TSLP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85480 HGNC: 30743 AceView: TSLP Ensembl:ENSG00000145777 euGenes: HUgn85480
    ECgene: TSLP Kegg: 85480 H-InvDB: TSLP

    Other Databases showing TSLP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TSLP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSLP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TSLP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TSLP gene:
    Search GeneIP for patents involving TSLP

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