Aliases for TSLP Gene
External Ids for TSLP Gene
- HGNC: 30743
- Entrez Gene: 85480
- Ensembl: ENSG00000145777
- OMIM: 607003
- UniProtKB: Q969D9
Previous GeneCards Identifiers for TSLP Gene
- GC05P110030
- GC05P110853
- GC05P110436
- GC05P110481
- GC05P110433
- GC05P110435
- GC05P110405
- GC05P105586
Summaries for TSLP Gene
-
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for TSLP Gene
TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Cryoglobulinemia, Familial Mixed and Cryoglobulinemia. Among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway (KEGG). GO annotations related to this gene include cytokine activity.
UniProtKB/Swiss-Prot for TSLP Gene
-
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
-
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSLP Gene
Genomics for TSLP Gene
Regulatory Elements for TSLP Gene
Enhancers for TSLP Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G111091 | 1.2 | ENCODE | 44.8 | +22.8 | 22793 | 2.6 | MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 | WDR36 TSLP RPS3AP21 BCLAF1P1 STARD4-AS1 ENSG00000253613 GC05P111128 |
| GH05G111075 | 1 | ENCODE | 45.5 | +3.2 | 3226 | 0.2 | ATF1 ARNT SIN3A FEZF1 ZNF2 YY1 GLIS2 KLF7 ZNF263 SP3 | TSLP WDR36 |
| GH05G111069 | 0.6 | ENCODE | 53 | +0.1 | 120 | 1.0 | CTCF JUND SUZ12 RBBP5 ZNF384 EZH2 | TSLP WDR36 |
| GH05G111223 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 10.4 | +161.6 | 161592 | 16.7 | HDGF PKNOX1 WRNIP1 SIN3A ZNF121 GLIS2 CBX5 ZNF207 FOS KLF7 | CAMK4 ENSG00000249318 TSLP WDR36 GC05M111236 |
| GH05G111136 | 0.7 | Ensembl ENCODE | 22.4 | +66.0 | 66045 | 0.2 | JUND FOS | TSLP WDR36 GC05P111128 GC05M111139 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TSLP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TSLP gene promoter:
Regulatory Element Products
Genomic Location for TSLP Gene
- Chromosome:
- 5
- Start:
- 111,070,062 bp from pter
- End:
- 111,078,024 bp from pter
- Size:
- 7,963 bases
- Orientation:
- Plus strand
Genomic View for TSLP Gene
Genes around TSLP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q22.1 by Ensembl
- 5q22.1 by Entrez Gene
- 5q22.1 by HGNC
TSLP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TSLP Gene
Proteins for TSLP Gene
-
Protein details for TSLP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969D9-TSLP_HUMAN
- Recommended name:
- Thymic stromal lymphopoietin
- Protein Accession:
- Q969D9
- G3XAM8
- Q8IW99
- Q96AU7
Protein attributes for TSLP Gene
- Size:
- 159 amino acids
- Molecular mass:
- 18141 Da
- Quaternary structure:
-
- Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
- SequenceCaution:
-
- Sequence=AAH16720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for TSLP Gene
Other Protein References for TSLP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TSLP (TSLP)
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-
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-
Abcam antibodies for TSLP
-
Cloud-Clone Corp. Antibodies for TSLP
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-
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Protein Products
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-
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Cloud-Clone Corp. Proteins for TSLP
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-
ProSci Proteins for TSLP
-
Abcam proteins for TSLP
Assay Products
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for TSLP (TSLP)
- antibodies-online Kits for TSLP: See all 80
-
Abcam assays for TSLP
No data available for DME Specific Peptides for TSLP Gene
Domains & Families for TSLP Gene
Suggested Antigen Peptide Sequences for TSLP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for TSLP Gene
Function for TSLP Gene
Molecular function for TSLP Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
- UniProtKB/Swiss-Prot Function:
- Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
- UniProtKB/Swiss-Prot Induction:
- Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
Phenotypes for TSLP Gene
- MGI mutant phenotypes for TSLP:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for TSLP:
Animal Models for TSLP Gene
Animal Model Products
-
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- Cyagen custom Knockout/knockin (KOKI) mouse models for TSLP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TSLP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TSLP gene
- Search ViGene Biosciences for TSLP
CRISPR Products
-
OriGene CRISPR knockouts for TSLP
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSLP
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miRNA for TSLP Gene
- miRTarBase miRNAs that target TSLP
-
- hsa-mir-335-5p (MIRT017769)
- hsa-mir-299-5p (MIRT527977)
- hsa-mir-5699-5p (MIRT527978)
- hsa-mir-4518 (MIRT527979)
- hsa-mir-1266-5p (MIRT527980)
- hsa-mir-6793-3p (MIRT527981)
- hsa-mir-6754-5p (MIRT527982)
- hsa-mir-4441 (MIRT527983)
- hsa-mir-4270 (MIRT527984)
- hsa-mir-211-3p (MIRT527985)
- hsa-mir-6769a-3p (MIRT527986)
- hsa-mir-3943 (MIRT527987)
- hsa-mir-4323 (MIRT527988)
- hsa-mir-6732-3p (MIRT527989)
- hsa-mir-652-5p (MIRT527990)
miRNA Products
- Search ViGene Biosciences for TSLP
Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TSLP
-
ViGene Biosciences adenoviral particle packaged cDNA for TSLP gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSLP Gene
Localization for TSLP Gene
Subcellular locations from UniProtKB/Swiss-Prot for TSLP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
Pathways & Interactions for TSLP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling | ||
| 2 | Jak-STAT signaling pathway (KEGG) | ||
| 3 | Innate Lymphoid Cell Differentiation Pathways | ||
| 4 | Development and heterogeneity of the ILC family | ||
Pathways by source for TSLP Gene
1 BioSystems pathway for TSLP Gene
2 KEGG pathways for TSLP Gene
1 R&D Systems pathway for TSLP Gene
Transcripts for TSLP Gene
mRNA/cDNA for TSLP Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TSLP Gene
CRISPR Products
-
OriGene CRISPR knockouts for TSLP
-
Santa Cruz Biotechnology (SCBT) CRISPR for TSLP
- GenScript: Design CRISPR guide RNA sequences for TSLP
miRNA Products
- Search ViGene Biosciences for TSLP
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TSLP
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-
ViGene Biosciences ready-to-package AAV shRNAs for TSLP gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TSLP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TSLP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for TSLP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Kidney (Urinary System)
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for TSLP Gene
This gene is overexpressed in Liver (x4.4) and Heart - Left Ventricle (x4.0).
NURSA nuclear receptor signaling pathways regulating expression of TSLP Gene:
TSLPSOURCE GeneReport for Unigene cluster for TSLP Gene:
Hs.389874mRNA Expression by UniProt/SwissProt for TSLP Gene:
Q969D9-TSLP_HUMAN
Tissue specificity:
Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.
Evidence on tissue expression from TISSUES for TSLP Gene
- Lung(4.5)
- Nervous system(4.2)
- Lymph node(2.6)
- Spleen(2.6)
- Blood(2.5)
- Skin(2.5)
Primer Products
-
OriGene qPCR primer pairs for TSLP
-
OriGene qPCR primer pairs and template standards for TSLP
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSLP Gene
Orthologs for TSLP Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TSLP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC617637 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tslp 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tslp 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TSLP 35 |
|
OneToOne |
- Species where no ortholog for TSLP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TSLP Gene
No data available for Paralogs for TSLP Gene
Variants for TSLP Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002184 | -- | 111,073,714(+) | TGGTG(C/T)AGAAG | intron-variant | |
| rs1000156319 | -- | 111,068,776(+) | AGTAC(A/G)GAAGA | upstream-variant-2KB | |
| rs1000829748 | -- | 111,078,461(+) | AGAAA(A/G)TCTAG | downstream-variant-500B | |
| rs1001005242 | -- | 111,075,043(+) | ATGAA(A/G)GAGAC | intron-variant | |
| rs1001110038 | -- | 111,070,079(+) | GGGGG(A/T)AGAGT | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5779n100 | CNV | gain | 25217958 |
| dgv5780n100 | CNV | gain | 25217958 |
| esv3606259 | CNV | loss | 21293372 |
| nsv1025735 | CNV | gain | 25217958 |
| nsv830447 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TSLP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSLP Gene
Disorders for TSLP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cryoglobulinemia, familial mixed |
|
|
| cryoglobulinemia |
|
|
| eczema herpeticum |
|
|
| allergic asthma |
|
|
| membranoproliferative glomerulonephritis |
|
Search TSLP in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TSLP
No data available for UniProtKB/Swiss-Prot and Genatlas for TSLP Gene
Publications for TSLP Gene
- Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PMID: 11418668) Reche P.A. … Bazan J.F. (J. Immunol. 2001) 2 3 4 22 64
- Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PMID: 11480573) Quentmeier H. … Lyman S.D. (Leukemia 2001) 2 3 4 22 64
- Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PMID: 20208534) Rothenberg M.E. … Hakonarson H. (Nat. Genet. 2010) 3 22 46 64
- A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. (PMID: 19539984) He J.Q. … Daley D. (J. Allergy Clin. Immunol. 2009) 3 22 46 64
- Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo. (PMID: 19555430) Cheong K.A. … Lee A.Y. (Exp. Dermatol. 2009) 3 22 46 64
Products for TSLP Gene
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- Find your target
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- Humanized Mice
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- antibodies-online Antibodies for TSLP: See all 139
- antibodies-online Kits for TSLP: See all 80
- antibodies-online Proteins for TSLP: See all 61
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- GeneTex TSLP antibody for TSLP
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- Custom Antibody ServicesProSci Antibodies for TSLP
- ProSci Proteins for TSLP
- Horizon Cell Lines for TSLP
- Cyagen custom Knockout/knockin (KOKI) mouse models for TSLP
- VectorBuilder custom plasmid, inducible vectors for TSLP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TSLP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TSLP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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