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Aliases for TSLP Gene

Aliases for TSLP Gene

  • Thymic Stromal Lymphopoietin 2 3 5

External Ids for TSLP Gene

Previous GeneCards Identifiers for TSLP Gene

  • GC05P110030
  • GC05P110853
  • GC05P110436
  • GC05P110481
  • GC05P110433
  • GC05P110435
  • GC05P110405
  • GC05P105586

Summaries for TSLP Gene

Entrez Gene Summary for TSLP Gene

  • This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for TSLP Gene

TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Cryoglobulinemia, Familial Mixed and Cryoglobulinemia. Among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway (KEGG). GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for TSLP Gene

  • Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

  • Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.

Gene Wiki entry for TSLP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSLP Gene

Genomics for TSLP Gene

Regulatory Elements for TSLP Gene

Enhancers for TSLP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G111091 1.2 ENCODE 44.8 +22.8 22793 2.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 WDR36 TSLP RPS3AP21 BCLAF1P1 STARD4-AS1 ENSG00000253613 GC05P111128
GH05G111075 1 ENCODE 45.5 +3.2 3226 0.2 ATF1 ARNT SIN3A FEZF1 ZNF2 YY1 GLIS2 KLF7 ZNF263 SP3 TSLP WDR36
GH05G111069 0.6 ENCODE 53 +0.1 120 1.0 CTCF JUND SUZ12 RBBP5 ZNF384 EZH2 TSLP WDR36
GH05G111223 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +161.6 161592 16.7 HDGF PKNOX1 WRNIP1 SIN3A ZNF121 GLIS2 CBX5 ZNF207 FOS KLF7 CAMK4 ENSG00000249318 TSLP WDR36 GC05M111236
GH05G111136 0.7 Ensembl ENCODE 22.4 +66.0 66045 0.2 JUND FOS TSLP WDR36 GC05P111128 GC05M111139
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSLP on UCSC Golden Path with GeneCards custom track

Genomic Location for TSLP Gene

Chromosome:
5
Start:
111,070,062 bp from pter
End:
111,078,024 bp from pter
Size:
7,963 bases
Orientation:
Plus strand

Genomic View for TSLP Gene

Genes around TSLP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSLP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSLP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSLP Gene

Proteins for TSLP Gene

  • Protein details for TSLP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969D9-TSLP_HUMAN
    Recommended name:
    Thymic stromal lymphopoietin
    Protein Accession:
    Q969D9
    Secondary Accessions:
    • G3XAM8
    • Q8IW99
    • Q96AU7

    Protein attributes for TSLP Gene

    Size:
    159 amino acids
    Molecular mass:
    18141 Da
    Quaternary structure:
    • Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
    SequenceCaution:
    • Sequence=AAH16720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TSLP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSLP Gene

Post-translational modifications for TSLP Gene

  • Glycosylation at posLast=6464 and Asn119
  • Modification sites at PhosphoSitePlus

Other Protein References for TSLP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TSLP (TSLP)
  • Abcam antibodies for TSLP

Protein Products

  • Abcam proteins for TSLP

Assay Products

  • Abcam assays for TSLP

No data available for DME Specific Peptides for TSLP Gene

Domains & Families for TSLP Gene

Protein Domains for TSLP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSLP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSLP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TSLP Gene

Function for TSLP Gene

Molecular function for TSLP Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
UniProtKB/Swiss-Prot Function:
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
UniProtKB/Swiss-Prot Induction:
Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.

Gene Ontology (GO) - Molecular Function for TSLP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with TSLP: view
genes like me logo Genes that share phenotypes with TSLP: view

Animal Models for TSLP Gene

MGI Knock Outs for TSLP:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSLP

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSLP Gene

Localization for TSLP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSLP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSLP gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TSLP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with TSLP: view

Pathways & Interactions for TSLP Gene

genes like me logo Genes that share pathways with TSLP: view

Pathways by source for TSLP Gene

1 R&D Systems pathway for TSLP Gene

SIGNOR curated interactions for TSLP Gene

Activates:

Gene Ontology (GO) - Biological Process for TSLP Gene

None

Drugs & Compounds for TSLP Gene

(4) Drugs for TSLP Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 6394
Antibodies, Monoclonal Pharma 4039
Immunoglobulins Pharma 6394

(3) Additional Compounds for TSLP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSLP: view

Transcripts for TSLP Gene

Unigene Clusters for TSLP Gene

Thymic stromal lymphopoietin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSLP Gene

No ASD Table

Relevant External Links for TSLP Gene

GeneLoc Exon Structure for
TSLP
ECgene alternative splicing isoforms for
TSLP

Expression for TSLP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSLP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSLP Gene

This gene is overexpressed in Liver (x4.4) and Heart - Left Ventricle (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of TSLP Gene:

TSLP

SOURCE GeneReport for Unigene cluster for TSLP Gene:

Hs.389874

mRNA Expression by UniProt/SwissProt for TSLP Gene:

Q969D9-TSLP_HUMAN
Tissue specificity: Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.

Evidence on tissue expression from TISSUES for TSLP Gene

  • Lung(4.5)
  • Nervous system(4.2)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Blood(2.5)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with TSLP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSLP Gene

Orthologs for TSLP Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSLP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSLP 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia LOC617637 34
  • 67.14 (n)
rat
(Rattus norvegicus)
Mammalia Tslp 34
  • 65.92 (n)
mouse
(Mus musculus)
Mammalia Tslp 34 16 35
  • 61.36 (n)
dog
(Canis familiaris)
Mammalia TSLP 35
  • 60 (a)
OneToOne
Species where no ortholog for TSLP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSLP Gene

ENSEMBL:
Gene Tree for TSLP (if available)
TreeFam:
Gene Tree for TSLP (if available)

Paralogs for TSLP Gene

No data available for Paralogs for TSLP Gene

Variants for TSLP Gene

Sequence variations from dbSNP and Humsavar for TSLP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000002184 -- 111,073,714(+) TGGTG(C/T)AGAAG intron-variant
rs1000156319 -- 111,068,776(+) AGTAC(A/G)GAAGA upstream-variant-2KB
rs1000829748 -- 111,078,461(+) AGAAA(A/G)TCTAG downstream-variant-500B
rs1001005242 -- 111,075,043(+) ATGAA(A/G)GAGAC intron-variant
rs1001110038 -- 111,070,079(+) GGGGG(A/T)AGAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSLP Gene

Variant ID Type Subtype PubMed ID
dgv5779n100 CNV gain 25217958
dgv5780n100 CNV gain 25217958
esv3606259 CNV loss 21293372
nsv1025735 CNV gain 25217958
nsv830447 CNV loss 17160897

Variation tolerance for TSLP Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSLP Gene

Human Gene Mutation Database (HGMD)
TSLP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSLP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSLP Gene

Disorders for TSLP Gene

MalaCards: The human disease database

(23) MalaCards diseases for TSLP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cryoglobulinemia, familial mixed
  • familial mixed cryoglobulinemia
cryoglobulinemia
  • cryoimmunoglobulinaemia
eczema herpeticum
  • eczema herpeticum [ambiguous]
allergic asthma
  • atopic asthma
membranoproliferative glomerulonephritis
  • chronic glomerulonephritis, lobular
- elite association - COSMIC cancer census association via MalaCards
Search TSLP in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSLP

Genetic Association Database (GAD)
TSLP
Human Genome Epidemiology (HuGE) Navigator
TSLP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSLP
genes like me logo Genes that share disorders with TSLP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSLP Gene

Publications for TSLP Gene

  1. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PMID: 11418668) Reche P.A. … Bazan J.F. (J. Immunol. 2001) 2 3 4 22 64
  2. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PMID: 11480573) Quentmeier H. … Lyman S.D. (Leukemia 2001) 2 3 4 22 64
  3. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PMID: 20208534) Rothenberg M.E. … Hakonarson H. (Nat. Genet. 2010) 3 22 46 64
  4. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. (PMID: 19539984) He J.Q. … Daley D. (J. Allergy Clin. Immunol. 2009) 3 22 46 64
  5. Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo. (PMID: 19555430) Cheong K.A. … Lee A.Y. (Exp. Dermatol. 2009) 3 22 46 64

Products for TSLP Gene

Sources for TSLP Gene

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