External Ids for TSLP Gene
Previous GeneCards Identifiers for TSLP Gene
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for TSLP Gene
TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Cryoglobulinemia, Familial Mixed and Cryoglobulinemia. Among its related pathways are Development and heterogeneity of the ILC family and Jak-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity.
UniProtKB/Swiss-Prot for TSLP Gene
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.