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TSLP Gene(Protein Coding)

Thymic Stromal Lymphopoietin

GCID:
GC05P111070
GIFtS:
48
Genes Participants
UDN Logo

Aliases for TSLP Gene

Aliases for TSLP Gene

  • Thymic Stromal Lymphopoietin 2 3 5

External Ids for TSLP Gene

Previous GeneCards Identifiers for TSLP Gene

  • GC05P110030
  • GC05P110853
  • GC05P110436
  • GC05P110481
  • GC05P110433
  • GC05P110435
  • GC05P110405
  • GC05P105586

Summaries for TSLP Gene

Entrez Gene Summary for TSLP Gene

  • This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for TSLP Gene

TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Cryoglobulinemia, Familial Mixed and Cryoglobulinemia. Among its related pathways are Development and heterogeneity of the ILC family and Jak-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for TSLP Gene

  • Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

  • Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.

Gene Wiki entry for TSLP Gene

Additional gene information for TSLP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSLP Gene

Genomics for TSLP Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TSLP Gene

Promoters and enhancers for TSLP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05I111072 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 595.6 +3.3 3339 1.2 ATF1 ARNT FEZF1 ZNF2 YY1 POLR2B GLIS2 KLF7 ATF7 ZNF263 TSLP WDR36
GH05I111071 Promoter 0.6 EPDnew 550.8 +1.6 1632 0.1 EZH2 TSLP WDR36
GH05I111069 Enhancer 0.5 ENCODE 603 +0.1 120 1 CTCF JUND SUZ12 POLR2A EZH2 TSLP WDR36
GH05I111091 Promoter/Enhancer 1.6 Ensembl ENCODE 44.8 +22.8 22792 2.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 WDR36 ENSG00000253613 RPS3AP21 TSLP SLC25A46 TMEM232 BCLAF1P1 STARD4-AS1 GC05P111128
GH05I111223 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +161.6 161592 16.7 HDGF PKNOX1 IRF4 ZNF121 GLIS2 ZNF207 ATF7 KLF7 FOS RUNX3 CAMK4 WDR36 RPS3AP21 ENSG00000249318 TSLP GC05M111236
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSLP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSLP gene promoter:

Genomic Locations for TSLP Gene

Genomic Locations for TSLP Gene
chr5:111,070,062-111,078,024
(GRCh38/hg38)
Size:
7,963 bases
Orientation:
Plus strand
chr5:110,405,760-110,413,722
(GRCh37/hg19)

Genomic View for TSLP Gene

Genes around TSLP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSLP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSLP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TSLP Gene

Proteins for TSLP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TSLP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969D9-TSLP_HUMAN
    Recommended name:
    Thymic stromal lymphopoietin
    Protein Accession:
    Q969D9
    Secondary Accessions:
    • G3XAM8
    • Q8IW99
    • Q96AU7

    Protein attributes for TSLP Gene

    Size:
    159 amino acids
    Molecular mass:
    18141 Da
    Quaternary structure:
    • Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.
    SequenceCaution:
    • Sequence=AAH16720.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22894.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TSLP Gene

    Alternative splice isoforms for TSLP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSLP Gene

Post-translational modifications for TSLP Gene

  • Glycosylation at isoforms=64 and posLast=119119

Other Protein References for TSLP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSLP Gene

Domains & Families for TSLP Gene

Gene Families for TSLP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TSLP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSLP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSLP: view

No data available for UniProtKB/Swiss-Prot for TSLP Gene

Function for TSLP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TSLP Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
UniProtKB/Swiss-Prot Function:
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
UniProtKB/Swiss-Prot Induction:
Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.

Phenotypes From GWAS Catalog for TSLP Gene

Gene Ontology (GO) - Molecular Function for TSLP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IMP 17242164
GO:0005139 interleukin-7 receptor binding IMP 11480573
genes like me logo Genes that share ontologies with TSLP: view
genes like me logo Genes that share phenotypes with TSLP: view

Animal Models for TSLP Gene

MGI Knock Outs for TSLP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSLP Gene

Localization for TSLP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSLP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSLP gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TSLP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with TSLP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSLP Gene

Pathways & Interactions for TSLP Gene

genes like me logo Genes that share pathways with TSLP: view

Pathways by source for TSLP Gene

1 BioSystems pathway for TSLP Gene
1 R&D Systems pathway for TSLP Gene

SIGNOR curated interactions for TSLP Gene

Activates:

Gene Ontology (GO) - Biological Process for TSLP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001961 positive regulation of cytokine-mediated signaling pathway IDA 11418668
GO:0008284 positive regulation of cell proliferation IMP 11480573
GO:0010469 regulation of receptor activity IEA --
GO:0032722 positive regulation of chemokine production IDA 11418668
GO:0032733 positive regulation of interleukin-10 production IMP 17242164
genes like me logo Genes that share ontologies with TSLP: view

Drugs & Compounds for TSLP Gene

Products:

  1. Drug

(4) Drugs for TSLP Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 7224
Antibodies, Monoclonal Pharma 4660
Immunoglobulins Pharma 7224

(3) Additional Compounds for TSLP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSLP: view

Transcripts for TSLP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TSLP Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSLP Gene

Thymic stromal lymphopoietin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSLP Gene

No ASD Table

Relevant External Links for TSLP Gene

GeneLoc Exon Structure for
TSLP
ECgene alternative splicing isoforms for
TSLP

Expression for TSLP Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSLP Gene

mRNA expression in normal human tissues for TSLP Gene
mRNA expression by GTEx for TSLP GenemRNA expression by BioGPS for TSLP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSLP Gene

This gene is overexpressed in Liver (x4.4) and Heart - Left Ventricle (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of TSLP Gene:

TSLP

SOURCE GeneReport for Unigene cluster for TSLP Gene:

Hs.389874

mRNA Expression by UniProt/SwissProt for TSLP Gene:

Q969D9-TSLP_HUMAN
Tissue specificity: Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.

Evidence on tissue expression from TISSUES for TSLP Gene

  • Lung(4.5)
  • Nervous system(4.2)
  • Blood(2.6)
  • Lymph node(2.6)
  • Skin(2.6)
  • Spleen(2.6)
genes like me logo Genes that share expression patterns with TSLP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSLP Gene

Orthologs for TSLP Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSLP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TSLP 33 34
  • 99.79 (n)
cow
(Bos Taurus)
 Mammalia LOC617637 33
  • 67.14 (n)
rat
(Rattus norvegicus)
 Mammalia Tslp 33
  • 65.92 (n)
mouse
(Mus musculus)
 Mammalia Tslp 33 16 34
  • 61.36 (n)
dog
(Canis familiaris)
 Mammalia TSLP 34
  • 60 (a)
 OneToOne
Species where no ortholog for TSLP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSLP Gene

ENSEMBL:
Gene Tree for TSLP (if available)
TreeFam:
Gene Tree for TSLP (if available)

Paralogs for TSLP Gene

No data available for Paralogs for TSLP Gene

Variants for TSLP Gene

Sequence variations from dbSNP and Humsavar for TSLP Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000002184 -- 111,073,714(+) C/T intron_variant
rs1000156319 -- 111,068,776(+) A/G upstream_transcript_variant
rs1000829748 -- 111,078,461(+) G/A downstream_transcript_variant
rs1001005242 -- 111,075,043(+) G/A intron_variant
rs1001110038 -- 111,070,079(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSLP Gene

Variant ID Type Subtype PubMed ID
dgv5779n100 CNV gain 25217958
dgv5780n100 CNV gain 25217958
esv3606259 CNV loss 21293372
nsv1025735 CNV gain 25217958
nsv830447 CNV loss 17160897

Variation tolerance for TSLP Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSLP Gene

Human Gene Mutation Database (HGMD)
TSLP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSLP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSLP Gene

Disorders for TSLP Gene

MalaCards: The human disease database

(24) MalaCards diseases for TSLP Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cryoglobulinemia, familial mixed
  • meltzer syndrome
cryoglobulinemia
  • cryoimmunoglobulinaemia
allergic asthma
  • atopic asthma
membranoproliferative glomerulonephritis
  • chronic glomerulonephritis, lobular
eczema herpeticum
  • eczema herpeticum [ambiguous]
- elite association - COSMIC cancer census association via MalaCards
Search TSLP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TSLP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TSLP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSLP Gene

Publications for TSLP Gene

  1. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PMID: 11418668) Reche PA … Bazan JF (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 22 58
  2. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. (PMID: 11480573) Quentmeier H … Lyman SD (Leukemia 2001) 2 3 4 22 58
  3. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PMID: 20208534) Rothenberg ME … Hakonarson H (Nature genetics 2010) 3 22 44 58
  4. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. (PMID: 19539984) He JQ … Daley D (The Journal of allergy and clinical immunology 2009) 3 22 44 58
  5. Association of thymic stromal lymphopoietin gene -847C>T polymorphism in generalized vitiligo. (PMID: 19555430) Cheong KA … Lee AY (Experimental dermatology 2009) 3 22 44 58

Products for TSLP Gene

Sources for TSLP Gene

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