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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSKU Gene

protein-coding   GIFtS: 50
GCID: GC11P076494

Tsukushi, Small Leucine Rich Proteoglycan

(Previous names: leucine rich repeat containing 54, tsukushin, tsukushi small...)
(Previous symbol: LRRC54)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tsukushi, Small Leucine Rich Proteoglycan1 2     Leucine-Rich Repeat-Containing Protein 542 3
LRRC541 2 3     E2-Induced Gene 4 Protein2 3
E2IG42 3 5     Tsukushi Small Leucine Rich Proteoglycan Homolog (Xenopus Laevis)1
TSK2 3 5     Tsukushi Homolog2
Leucine Rich Repeat Containing 541 2     Tsukushi Small Leucine Rich Proteoglycan Homolog2
tsukushin1 2     Tsukushi3

External Ids:    HGNC: 288501   Entrez Gene: 259872   Ensembl: ENSG000001827047   OMIM: 6080155   UniProtKB: Q8WUA83   

Export aliases for TSKU gene to outside databases

Previous GC identifers: GC11P076171 GC11P072791


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSKU Gene: 
TSKU (tsukushi, small leucine rich proteoglycan) is a protein-coding gene. Diseases associated with TSKU include systemic scleroderma, and fibromyalgia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSKU gene promoter:
         COUP-TF1   AP-1   COUP   Nkx5-1   Evi-1   Egr-4   GATA-1   GATA-2   AREB6   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSKU promoter sequence
   Search SABiosciences Chromatin IP Primers for TSKU

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSKU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5

TSKU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSKU gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P076494:  view genomic region     (about GC identifiers)

Start:
76,493,295 bp from pter      End:
76,509,198 bp from pter
Size:
15,904 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8 (See protein sequence)
Recommended Name: Tsukushin precursor  
Size: 353 amino acids; 37807 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B3KQT7 Q6UXK1 Q9UG10 Q9UJX9

Explore the universe of human proteins at neXtProt for TSKU: NX_Q8WUA8

Explore proteomics data for TSKU at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WUA8

  • TSKU Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSKU Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001245139.1  NP_056331.2  

    ENSEMBL proteins: 
     ENSP00000435133   ENSP00000332668   ENSP00000434873   ENSP00000434847  

    Human Recombinant Protein Products for TSKU: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TSKU (Tsukushi/TSK)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TSKU
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TSKU
    GenScript Custom Purified and Recombinant Proteins Services for TSKU
    Novus Biologicals TSKU Proteins
    Novus Biologicals TSKU Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    TSKU for ontologies           About GeneDecksing



    TSKU Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TSKU (Tsukushi/TSK)
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    GenScript Custom Superior Antibodies Services for TSKU
    Novus Biologicals TSKU Antibodies
    Abcam antibodies for TSKU
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for TSKU
    LSBio Antibodies in human, mouse, rat for TSKU 

    Assay Products for TSKU: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSKU
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q8WUA8

    ProtoNet protein and cluster: Q8WUA8

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    TSKU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSK_HUMAN, Q8WUA8
    Induction: By 17-beta-estradiol

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TSKU for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSKU:
     Decreased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tsku):
     nervous system 

    TSKU for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSKU 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSKU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSKU 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSKU 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSKU:
    hsa-mir-124 (MIRT004908)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSKU
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TSKU (see all 20):
    hsa-miR-1271 hsa-miR-29b-1* hsa-miR-105 hsa-miR-124 hsa-miR-4274 hsa-miR-7-1* hsa-miR-3662 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTSKU 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSKU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSKU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSKU
    Sirion Biotech Customized adenovirus for overexpression of TSKU

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TSKU (see all 11)
    OriGene ORF clones in mouse, rat for TSKU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSKU (NM_015516)
    Sino Biological Human cDNA Clone for TSKU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSKU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKU
    Sirion Biotech Customized lentivirus for stable overexpression of TSKU 
                         Customized lentivirus expression plasmids for stable overexpression of TSKU 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSKU
    Search LifeMap BioReagents cell lines for TSKU
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKU


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSKU

    1 Interacting protein for TSKU (Q8WUA82, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61667 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010468regulation of gene expression IEA--
    GO:0021540corpus callosum morphogenesis IEA--
    GO:0021670lateral ventricle development IEA--
    GO:0021960anterior commissure morphogenesis IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway IEA--

    TSKU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSKU (TSK)

    Search CenterWatch for drugs/clinical trials and news about TSKU / TSK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSKU gene (2 alternative transcripts): 
    NM_001258210.1  NM_015516.3  

    Unigene Cluster for TSKU:

    Tsukushi, small leucine rich proteoglycan
    Hs.8361  [show with all ESTs]
    Unigene Representative Sequence: AK126536
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533752 ENST00000333090(uc001oxt.3) ENST00000525167 ENST00000527881

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSKU
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TSKU (see all 20):
    hsa-miR-1271 hsa-miR-29b-1* hsa-miR-105 hsa-miR-124 hsa-miR-4274 hsa-miR-7-1* hsa-miR-3662 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTSKU 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSKU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSKU
    Clone
    Products:
         
    OriGene clones in human, mouse for TSKU (see all 11)
    OriGene ORF clones in mouse, rat for TSKU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSKU (NM_015516)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSKU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKU
    Sirion Biotech Customized lentivirus for stable overexpression of TSKU 
                         Customized lentivirus expression plasmids for stable overexpression of TSKU 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSKU
    OriGene qSTAR qPCR primer pairs in human, mouse for TSKU
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSKU
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSKU
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSKU

    Additional mRNA sequence: 

    AF191019.1 AK075476.1 AK091475.1 AK126536.1 AK313405.1 AL110276.1 AY358317.1 BC020975.1 
    BT007440.1 

    10 DOTS entries:

    DT.417669  DT.100777424  DT.100754481  DT.120701703  DT.91768837  DT.100777423  DT.91768832  DT.120701695 
    DT.120701697  DT.40215150 

    24/258 AceView cDNA sequences (see all 258):

    CA306394 AA335297 Z41115 AW190667 AA335299 BU855121 BF725906 AA305745 
    AI074399 AA651701 BX365318 BU859186 NM_015516 BE336901 BQ919451 AW183447 
    BE786245 BG056788 BX324380 BE208375 AI613032 AW612425 BU539454 CB051400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSKU expression in normal human tissues (normalized intensities)      TSKU embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATCAGGG
    TSKU Expression
    About this image


    TSKU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Adipose (Muscoskeletal System)
             adipose tissue   

    See TSKU Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSKU

    SOURCE GeneReport for Unigene cluster: Hs.8361
        SABiosciences Custom PCR Arrays for TSKU
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TSKU
    OriGene qSTAR qPCR primer pairs in human, mouse for TSKU
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSKU
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSKU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TSKU gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsku1 , 5 tsukushi1, 5 82.57(n)1
    85.63(a)1
      7 (53.66 cM)5
    2441521  NM_001024619.31  NP_001019790.11 
     983506685 
    chicken
    (Gallus gallus)
    Aves TSKU1 tsukushi small leucine rich proteoglycan homolog (Xenopus more 60.12(n)
    57.01(a)
      419088  NM_001005346.1  NP_001005346.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSKU6
    Uncharacterized protein
    54(a)
    1 ↔ 1
    AAWZ02036615(20249-21304)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd51d022 wufd51d02 79.24(n)   325958  BC047843.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50966
    CG77026
    --
    18(a)
    16(a)
    many → 1
    many → 1
    2L(10382263-10384723)
    3R(14495114-14500401)


    ENSEMBL Gene Tree for TSKU (if available)
    TreeFam Gene Tree for TSKU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/435 SNPs in TSKU are shown (see all 435)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807416591,2
    --76491507(+) GTCCCC/TGACAT 1 -- us2k10--------
    rs1863066811,2
    --76491623(+) CCAGAC/GAGAGG 1 -- us2k10--------
    rs1891519791,2
    --76491642(+) GGGGCA/GAAGAC 1 -- us2k10--------
    rs1818737801,2
    --76491725(+) TTGGGA/TTGTGT 1 -- us2k10--------
    rs1860343671,2
    --76491828(+) TTGCCA/GTTGAA 1 -- us2k10--------
    rs1917643091,2
    --76491975(+) GAGGGG/TAGGTG 1 -- us2k10--------
    rs1442681851,2
    --76491987(+) GTAAAA/GTTCAT 1 -- us2k10--------
    rs1465869491,2
    --76492178(+) CACACA/CGTGCA 1 -- us2k10--------
    rs71074091,2
    C,F,A--76492195(+) GTTAGC/TTTCCC 1 -- us2k110Minor allele frequency- T:0.26NA WA CSA EA 372
    rs1144665691,2
    --76492216(+) GGCAGC/TTGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSKU (76493295 - 76509198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TSKU:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897931CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSKU
    DNA2.0 Custom Variant and Variant Library Synthesis for TSKU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608015    OMIM disorders: --

    4 diseases for TSKU:    About MalaCards
    systemic scleroderma    fibromyalgia    scleroderma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TSKU:
    Fibromyalgia

    TSKU for disorders           About GeneDecksing


    Export disorders for TSKU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSKU gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TSKU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PubMed id 11085516)1, 2, 3 Charpentier A.H.... Aldaz C.M. (2000)
    2. Stromal expression of decorin, Semaphorin6D, SPARC, Sp routy1 and Tsukushi in developing prostate and decreased levels of decorin in pr ostate cancer. (PubMed id 22880013)1, 3 Henke A....Thomson A.A. (2012)
    3. Comparative analysis of gene regulation by the transc ription factor PPARalpha between mouse and human. (PubMed id 19710929)1, 3 Rakhshandehroo M....Kersten S. (2009)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Tsukushi controls the hair cycle by regulating TGF-b1 signaling. (PubMed id 22995554)1 Niimori D....Ohta K. (2012)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25987 HGNC: 28850 AceView: TSK Ensembl:ENSG00000182704 euGenes: HUgn25987
    ECgene: TSKU H-InvDB: TSKU

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSKU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSKU gene:
    Search GeneIP for patents involving TSKU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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