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Aliases for TSKU Gene

Aliases for TSKU Gene

  • Tsukushi, Small Leucine Rich Proteoglycan 2 3
  • E2IG4 3 4 6
  • TSK 3 4 6
  • Leucine-Rich Repeat-Containing Protein 54 3 4
  • Leucine Rich Repeat Containing 54 2 3
  • E2-Induced Gene 4 Protein 3 4
  • Tsukushin 2 3
  • LRRC54 3 4
  • Tsukushi Small Leucine Rich Proteoglycan Homolog (Xenopus Laevis) 2
  • Tsukushi Small Leucine Rich Proteoglycan Homolog 3
  • Tsukushi Homolog 3
  • Tsukushi 4

External Ids for TSKU Gene

Previous HGNC Symbols for TSKU Gene

  • LRRC54

Previous GeneCards Identifiers for TSKU Gene

  • GC11P076171
  • GC11P076494
  • GC11P072791

Summaries for TSKU Gene

GeneCards Summary for TSKU Gene

TSKU (Tsukushi, Small Leucine Rich Proteoglycan) is a Protein Coding gene. Among its related pathways are TGF-beta Signaling Pathway (sino).

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSKU Gene

Genomics for TSKU Gene

Regulatory Elements for TSKU Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSKU Gene

Start:
76,782,251 bp from pter
End:
76,798,154 bp from pter
Size:
15,904 bases
Orientation:
Plus strand

Genomic View for TSKU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSKU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSKU Gene

Proteins for TSKU Gene

  • Protein details for TSKU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA8-TSK_HUMAN
    Recommended name:
    Tsukushin
    Protein Accession:
    Q8WUA8
    Secondary Accessions:
    • B3KQT7
    • Q6UXK1
    • Q9UG10
    • Q9UJX9

    Protein attributes for TSKU Gene

    Size:
    353 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSKU Gene

Proteomics data for TSKU Gene at MOPED

Post-translational modifications for TSKU Gene

  • Glycosylation at Asn74, Asn137, Thr152, Thr153, and Ser248
  • Modification sites at PhosphoSitePlus

Other Protein References for TSKU Gene

No data available for DME Specific Peptides for TSKU Gene

Domains for TSKU Gene

Suggested Antigen Peptide Sequences for TSKU Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUA8

UniProtKB/Swiss-Prot:

TSK_HUMAN :
  • Q8WUA8
Domain:
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TSKU: view

No data available for Gene Families for TSKU Gene

Function for TSKU Gene

Molecular function for TSKU Gene

UniProtKB/Swiss-Prot Induction: By 17-beta-estradiol

Gene Ontology (GO) - Molecular Function for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TSKU: view

Phenotypes for TSKU Gene

MGI mutant phenotypes for TSKU:
inferred from 1 alleles
GenomeRNAi human phenotypes for TSKU:
genes like me logo Genes that share phenotypes with TSKU: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSKU Gene

Localization for TSKU Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSKU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSKU Gene COMPARTMENTS Subcellular localization image for TSKU gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with TSKU: view

Pathways for TSKU Gene

SuperPathways for TSKU Gene

genes like me logo Genes that share pathways with TSKU: view

Pathways by source for TSKU Gene

1 Sino Biological pathway for TSKU Gene

Interacting Proteins for TSKU Gene

Gene Ontology (GO) - Biological Process for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
GO:0021540 corpus callosum morphogenesis IEA --
GO:0021670 lateral ventricle development IEA --
GO:0021960 anterior commissure morphogenesis IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TSKU: view

Transcripts for TSKU Gene

Unigene Clusters for TSKU Gene

Tsukushi, small leucine rich proteoglycan:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSKU

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSKU Gene

No ASD Table

Relevant External Links for TSKU Gene

GeneLoc Exon Structure for
TSKU
ECgene alternative splicing isoforms for
TSKU

Expression for TSKU Gene

mRNA expression in normal human tissues for TSKU Gene

mRNA differential expression in normal tissues according to GTEx for TSKU Gene

This gene is overexpressed in Liver (5.8) and Cervix - Ectocervix (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSKU Gene

SOURCE GeneReport for Unigene cluster for TSKU Gene Hs.8361

genes like me logo Genes that share expressions with TSKU: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TSKU Gene

Orthologs for TSKU Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSKU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSKU 35
  • 98.02 (n)
  • 96.32 (a)
TSKU 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSKU 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSKU 35
  • 86.43 (n)
  • 87.21 (a)
TSKU 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsku 35
  • 82.43 (n)
  • 85.39 (a)
Tsku 16
Tsku 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSKU 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSKU 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsku 35
  • 81.42 (n)
  • 85.34 (a)
chicken
(Gallus gallus)
Aves TSKU 35
  • 60.12 (n)
  • 57.01 (a)
TSKU 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSKU 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tsku 35
  • 58.95 (n)
  • 50.45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2453 35
zebrafish
(Danio rerio)
Actinopterygii tsku 35
  • 54.05 (n)
  • 50.46 (a)
tsku 36
  • 46 (a)
OneToOne
wufd51d02 35
Species with no ortholog for TSKU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSKU Gene

ENSEMBL:
Gene Tree for TSKU (if available)
TreeFam:
Gene Tree for TSKU (if available)

Paralogs for TSKU Gene

No data available for Paralogs for TSKU Gene

Variants for TSKU Gene

Sequence variations from dbSNP and Humsavar for TSKU Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7912 -- 76,797,799(+) CAGGG(C/T)AGCAT utr-variant-3-prime
rs1149612 -- 76,785,692(+) GGGGA(C/T)TTGAG intron-variant
rs1149613 -- 76,786,388(-) CATTT(C/G)ATTCA intron-variant
rs1149614 -- 76,786,519(-) TAAAA(C/T)CCATC intron-variant
rs1149615 -- 76,787,089(-) CTAAC(A/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSKU Gene

Variant ID Type Subtype PubMed ID
nsv897931 CNV Loss 21882294

Relevant External Links for TSKU Gene

HapMap Linkage Disequilibrium report
TSKU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSKU Gene

Disorders for TSKU Gene

(1) University of Copenhagen DISEASES for TSKU Gene

genes like me logo Genes that share disorders with TSKU: view

No data available for UniProtKB/Swiss-Prot for TSKU Gene

Publications for TSKU Gene

  1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier A.H. … Aldaz C.M. (Cancer Res. 2000) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. (PMID: 19710929) Rakhshandehroo M. … Kersten S. (PLoS ONE 2009) 2 3
  4. Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer. (PMID: 22880013) Henke A. … Thomson A.A. (PLoS ONE 2012) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TSKU Gene

Sources for TSKU Gene

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