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Aliases for TSKU Gene

Aliases for TSKU Gene

  • Tsukushi, Small Leucine Rich Proteoglycan 2 3 5
  • Leucine-Rich Repeat-Containing Protein 54 3 4
  • Leucine Rich Repeat Containing 54 2 3
  • E2-Induced Gene 4 Protein 3 4
  • Tsukushin 2 3
  • LRRC54 3 4
  • E2IG4 3 4
  • TSK 3 4
  • Tsukushi Small Leucine Rich Proteoglycan Homolog (Xenopus Laevis) 2
  • Tsukushi Small Leucine Rich Proteoglycan Homolog 3
  • Tsukushi Homolog 3
  • Tsukushi 4

External Ids for TSKU Gene

Previous HGNC Symbols for TSKU Gene

  • LRRC54

Previous GeneCards Identifiers for TSKU Gene

  • GC11P076171
  • GC11P076494
  • GC11P072791

Summaries for TSKU Gene

GeneCards Summary for TSKU Gene

TSKU (Tsukushi, Small Leucine Rich Proteoglycan) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation.

Additional gene information for TSKU Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSKU Gene

Genomics for TSKU Gene

Regulatory Elements for TSKU Gene

Enhancers for TSKU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H076786 1.5 Ensembl ENCODE dbSUPER 15 +6.4 6399 4.1 PKNOX1 ATF1 ARID4B SIN3A ZBTB7B TCF12 ZNF121 CBX5 GATA2 ATF7 LOC101928837 ENSG00000254632 ENSG00000261578 TSKU EMSY GC11P076787
GH11H076698 1.6 Ensembl ENCODE dbSUPER 11.4 -80.5 -80505 6.9 HDGF PKNOX1 ARNT ZNF766 FOS ZC3H11A REST SMARCB1 ZNF592 MEF2D LOC107984360 ENSG00000254810 LOC101928837 TSKU ENSG00000254632 ACER3 EMSY GC11P076710 ENSG00000254975
GH11H076806 1.4 Ensembl ENCODE dbSUPER 12.2 +25.3 25302 1.1 YBX3 HDGF ATF1 RB1 SIN3A YBX1 NFXL1 RAD21 YY1 ZNF366 ACER3 LOC101928837 TSKU ENSG00000255363 EMSY B3GNT6 ENSG00000261578
GH11H076379 1.1 ENCODE 14.7 -401.1 -401086 3.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 TSKU ENSG00000261578 ENSG00000255363 LOC101928837 ENSG00000255135 THAP12 LOC100506127
GH11H076780 1.4 ENCODE dbSUPER 8.2 +1.0 978 5 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 EMSY LOC101928837 UVRAG TSKU ENSG00000254632 GC11P076787
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSKU on UCSC Golden Path with GeneCards custom track

Promoters for TSKU Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042354 1449 2601 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5

Genomic Locations for TSKU Gene

Genomic Locations for TSKU Gene
chr11:76,782,251-76,798,154
(GRCh38/hg38)
Size:
15,904 bases
Orientation:
Plus strand
chr11:76,493,295-76,509,198
(GRCh37/hg19)

Genomic View for TSKU Gene

Genes around TSKU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSKU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSKU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSKU Gene

Proteins for TSKU Gene

  • Protein details for TSKU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA8-TSK_HUMAN
    Recommended name:
    Tsukushin
    Protein Accession:
    Q8WUA8
    Secondary Accessions:
    • B3KQT7
    • Q6UXK1
    • Q9UG10
    • Q9UJX9

    Protein attributes for TSKU Gene

    Size:
    353 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSKU Gene

Post-translational modifications for TSKU Gene

  • Glycosylation at posLast=7474, Asn137, Thr152, Thr153, and Ser248
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSKU Gene

Domains & Families for TSKU Gene

Gene Families for TSKU Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TSKU Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSKU: view

No data available for UniProtKB/Swiss-Prot for TSKU Gene

Function for TSKU Gene

Molecular function for TSKU Gene

UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol.

Gene Ontology (GO) - Molecular Function for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with TSKU: view
genes like me logo Genes that share phenotypes with TSKU: view

Animal Models for TSKU Gene

MGI Knock Outs for TSKU:

miRNA for TSKU Gene

miRTarBase miRNAs that target TSKU

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSKU Gene

Localization for TSKU Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSKU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSKU gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with TSKU: view

Pathways & Interactions for TSKU Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with TSKU: view

Pathways by source for TSKU Gene

1 BioSystems pathway for TSKU Gene

Interacting Proteins for TSKU Gene

Gene Ontology (GO) - Biological Process for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0010468 regulation of gene expression IEA --
GO:0021540 corpus callosum morphogenesis IEA --
GO:0021670 lateral ventricle development IEA --
GO:0021960 anterior commissure morphogenesis IEA --
genes like me logo Genes that share ontologies with TSKU: view

No data available for SIGNOR curated interactions for TSKU Gene

Drugs & Compounds for TSKU Gene

No Compound Related Data Available

Transcripts for TSKU Gene

Unigene Clusters for TSKU Gene

Tsukushi, small leucine rich proteoglycan:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSKU Gene

No ASD Table

Relevant External Links for TSKU Gene

GeneLoc Exon Structure for
TSKU
ECgene alternative splicing isoforms for
TSKU

Expression for TSKU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSKU Gene

mRNA differential expression in normal tissues according to GTEx for TSKU Gene

This gene is overexpressed in Liver (x5.8) and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for TSKU Gene

This gene is overexpressed in Plasma (54.7) and Placenta (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSKU Gene



Protein tissue co-expression partners for TSKU Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSKU Gene:

TSKU

SOURCE GeneReport for Unigene cluster for TSKU Gene:

Hs.8361

Evidence on tissue expression from TISSUES for TSKU Gene

  • Intestine(4.6)
  • Skin(3.6)
  • Nervous system(3.1)
  • Heart(2.5)
  • Lung(2)
genes like me logo Genes that share expression patterns with TSKU: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSKU Gene

Orthologs for TSKU Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSKU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSKU 33 34
  • 98.02 (n)
dog
(Canis familiaris)
Mammalia TSKU 33 34
  • 86.43 (n)
mouse
(Mus musculus)
Mammalia Tsku 33 16 34
  • 82.43 (n)
rat
(Rattus norvegicus)
Mammalia Tsku 33
  • 81.42 (n)
cow
(Bos Taurus)
Mammalia TSKU 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSKU 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSKU 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSKU 33 34
  • 60.12 (n)
lizard
(Anolis carolinensis)
Reptilia TSKU 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tsku 33
  • 58.95 (n)
zebrafish
(Danio rerio)
Actinopterygii tsku 33 34
  • 54.05 (n)
wufd51d02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2453 33
Species where no ortholog for TSKU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSKU Gene

ENSEMBL:
Gene Tree for TSKU (if available)
TreeFam:
Gene Tree for TSKU (if available)

Paralogs for TSKU Gene

No data available for Paralogs for TSKU Gene

Variants for TSKU Gene

Sequence variations from dbSNP and Humsavar for TSKU Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000116931 -- 76,783,363(+) GGCCG(C/T)CGGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000204734 -- 76,788,733(+) CCTGG(C/T)CTGGG intron-variant
rs1000352507 -- 76,795,280(+) CTAGG(C/T)AGGGA intron-variant
rs1000629388 -- 76,794,623(+) ACTGC(C/G)TGCCC intron-variant
rs1000861856 -- 76,784,495(+) GGCCC(C/T)TGTGC intron-variant, upstream-variant-2KB

Variation tolerance for TSKU Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSKU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSKU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSKU Gene

Disorders for TSKU Gene

Relevant External Links for TSKU

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSKU

No disorders were found for TSKU Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSKU Gene

Publications for TSKU Gene

  1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier AH … Aldaz CM (Cancer research 2000) 2 3 4 60
  2. Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer. (PMID: 22880013) Henke A … Thomson AA (PloS one 2012) 2 3 60
  3. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. (PMID: 19710929) Rakhshandehroo M … Kersten S (PloS one 2009) 2 3 60
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TSKU Gene

Sources for TSKU Gene

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