Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TSKU Gene

protein-coding GIFtS: 50
GCID: GC11P076494

tsukushi, small leucine rich proteoglycan

(Previous names: leucine rich repeat containing 54, tsukushin, tsukushi...)
(Previous symbol: LRRC54)

Explore 3 diseases affiliated with
TSKU via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tsukushi, Small Leucine Rich Proteoglycan¹ ²		Leucine-Rich Repeat-Containing Protein 54² ³
E2IG4¹ ² ³ ⁵		E2-Induced Gene 4 Protein² ³
TSK¹ ² ³ ⁵		Tsukushi Small Leucine Rich Proteoglycan Homolog (Xenopus Laevis)¹
LRRC54¹ ² ³		Tsukushi Homolog²
Leucine Rich Repeat Containing 54¹ ²		Tsukushi Small Leucine Rich Proteoglycan Homolog²
Tsukushin¹		Tsukushi³

External Ids:	HGNC: 28850¹	Entrez Gene: 25987²	Ensembl: ENSG00000182704⁷	OMIM: 608015⁵	UniProtKB: Q8WUA8³

Export aliases for TSKU gene to outside databases

Previous GC identifers: GC11P076171 GC11P072791

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TSKU gene promoter:
COUP-TF1 AP-1 COUP Nkx5-1 Evi-1 Egr-4 GATA-1 GATA-2 AREB6 COUP-TF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSKU promoter sequence

Search SABiosciences Chromatin IP Primers for TSKU

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSKU

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.5

TSKU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSKU gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P076494: view genomic region (about GC identifiers)

Start:	76,493,295 bp from pter	End:	76,509,198 bp from pter
Size:	15,904 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8 (See protein sequence)

Recommended Name: Tsukushin precursor

Size: 353 amino acids; 37807 Da

Subcellular location: Secreted (Potential)

Secondary accessions: B3KQT7 Q6UXK1 Q9UG10 Q9UJX9

Explore the universe of human proteins at neXtProt for TSKU: NX_Q8WUA8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WUA8

TSKU Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001245139.1 NP_056331.2

ENSEMBL proteins:

ENSP00000435133 ENSP00000332668 ENSP00000434873 ENSP00000434847

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TSKU (Tsukushi/TSK)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TSKU OriGene Custom Protein Services for TSKU
	GenScript Custom Purified and Recombinant Proteins Services for TSKU
	Novus Biologicals TSKU Proteins Novus Biologicals TSKU Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TSKU

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

TSKU for ontologies About GeneDecksing

TSKU Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TSKU (Tsukushi/TSK)
	Browse OriGene Antibodies OriGene Custom Antibody Services for TSKU
	GenScript Custom Superior Antibodies Services for TSKU
	Novus Biologicals TSKU Antibodies
	Search for Antibodies for TSKU at Abcam
	Uscn Antibodies for TSKU
	ThermoFisher Antibodies for TSKU

Assay Products for TSKU:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TSKU
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TSKU

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TSKU for domains About GeneDecksing

3 InterPro domains/families:

IPR000372 LRR-contain_N

IPR001611 Leu-rich_rpt

IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry Q8WUA8

ProtoNet protein and cluster: Q8WUA8

1 Blocks protein family: IPB000372 Cysteine-rich flanking region

UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8

Similarity: Contains 10 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRNT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8

Induction: By 17-beta-estradiol

miRNA Products:		miRTarBase miRNAs that target TSKU: hsa-mir-124 (MIRT004908)

		OriGene 3'-UTR Clone: TSKU Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSKU
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TSKU (see all 20):
		hsa-miR-1271 hsa-miR-29b-1* hsa-miR-105 hsa-miR-124 hsa-miR-4274 hsa-miR-7-1* hsa-miR-3662 hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: TSKU 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSKU (see all 7) OriGene shRNA RFP: TSKU OriGene siRNA: TSKU
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSKU

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TSKU

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSKU (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSKU (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TSKU (NM_015516)
		Sino Biological Human cDNA Clone for TSKU
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSKU
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKU

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TSKU
		Search LifeMap BioReagents cell lines for TSKU

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKU

1 GenomeRNAi human phenotype for TSKU:

Decreased homologous recombina

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Tsku):

nervous system

TSKU for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TSKU

1 Interacting protein for TSKU (Q8WUA8^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKIL	P12757²^,³	MINT-61667 I2D: score=3

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0021540	corpus callosum morphogenesis	IEA	--
GO:0021670	lateral ventricle development	IEA	--
GO:0021960	anterior commissure morphogenesis	IEA	--

TSKU for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSKU
Search CenterWatch for drugs/clinical trials and news about TSKU / TSK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSKU gene (2 alternative transcripts):

NM_001258210.1 NM_015516.3

Unigene Cluster for TSKU:

Tsukushi, small leucine rich proteoglycan

Hs.8361 [show with all ESTs]

Unigene Representative Sequence: AK126536

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000533752 ENST00000333090(uc001oxt.3) ENST00000525167 ENST00000527881

miRNA Products:		OriGene 3'-UTR Clone: TSKU Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSKU
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TSKU (see all 20):
		hsa-miR-1271 hsa-miR-29b-1* hsa-miR-105 hsa-miR-124 hsa-miR-4274 hsa-miR-7-1* hsa-miR-3662 hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: TSKU 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSKU (see all 7) OriGene shRNA RFP: TSKU OriGene siRNA: TSKU
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSKU

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSKU (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSKU (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TSKU (NM_015516)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSKU
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKU

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSKU Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TSKU
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSKU
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSKU

Additional cDNA sequence:

AF191019.1 AK075476.1 AK091475.1 AK126536.1 AK313405.1 AL110276.1 AY358317.1 BC020975.1

BT007440.1

10 DOTS entries:

DT.417669 DT.100777424 DT.100754481 DT.120701703 DT.91768837 DT.100777423 DT.91768832 DT.120701695

DT.120701697 DT.40215150

24/258 AceView cDNA sequences (see all 258):

AW612425 AA558470 BE786245 BU859186 CB051400 BQ919451 BX324380 AI884558

BM679949 BU846213 CB242473 AW183447 NM_015516 AI613032 BE312814 CA306394

AI074139 BM702062 BG056788 BF724678 AA335299 AA651701 BX324381 BM704369

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSKU expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCATCAGGG

About this image

TSKU expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TSKU Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSKU

SOURCE GeneReport for Unigene cluster: Hs.8361

SABiosciences Custom PCR Arrays for TSKU

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSKU Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TSKU
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSKU
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSKU

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKU

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TSKU gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tsku^{1 , 5}	tsukushi^{1, 5}	82.57(n)¹ 85.63(a)¹		7 (53.66 cM)⁵ 244152¹ NM_001024619.3¹ NP_001019790.1¹ 98350668⁵
chicken (Gallus gallus)	Aves	TSKU¹	tsukushi small leucine rich proteoglycan homolog (Xenopus more	60.12(n) 57.01(a)		419088 NM_001005346.1 NP_001005346.1
lizard (Anolis carolinensis)	Reptilia	TSKU⁶	--	54(a)	1 ↔ 1	AAWZ02036615(20249-21304)
zebrafish (Danio rerio)	Actinopterygii	wufd51d02²	wufd51d02	79.24(n)		325958 BC047843.1

ENSEMBL Gene Tree for TSKU (if available)
TreeFam Gene Tree for TSKU (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180741659^1,2		--	76491507(+)	`GTCCCC/TGACAT`	1	--	us2k¹		0	--	--	--	--
rs186306681^1,2		--	76491623(+)	`CCAGAC/GAGAGG`	1	--	us2k¹		0	--	--	--	--
rs189151979^1,2		--	76491642(+)	`GGGGCA/GAAGAC`	1	--	us2k¹		0	--	--	--	--
rs181873780^1,2		--	76491725(+)	`TTGGGA/TTGTGT`	1	--	us2k¹		0	--	--	--	--
rs186034367^1,2		--	76491828(+)	`TTGCCA/GTTGAA`	1	--	us2k¹		0	--	--	--	--
rs191764309^1,2		--	76491975(+)	`GAGGGG/TAGGTG`	1	--	us2k¹		0	--	--	--	--
rs144268185^1,2		--	76491987(+)	`GTAAAA/GTTCAT`	1	--	us2k¹		0	--	--	--	--
rs146586949^1,2		--	76492178(+)	`CACACA/CGTGCA`	1	--	us2k¹		0	--	--	--	--
rs7107409^1,2	C,F,A,	--	76492195(+)	`GTTAGC/TTTCCC`	1	--	us2k¹		10		NA WA CSA EA	372
rs114466569^1,2		--	76492216(+)	`GGCAGC/TTGGGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TSKU (76493295 - 76509198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSKU: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSKU

DNA2.0 Custom Variant and Variant Library Synthesis for TSKU

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TSKU for disorders           About GeneDecksing

OMIM gene information: 608015    OMIM disorders: --

3 diseases for TSKU:    About MalaCards

systemic scleroderma scleroderma fibromyalgia

1 disease from the University of Copenhagen DISEASES database for TSKU:

Fibromyalgia

Export disorders for TSKU gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TSKU gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TSKU)

Utopia: connect your pdf to the dynamic
world of online information

Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PubMed id 11085516)^{1, 2, 3} Charpentier A.H.... Aldaz C.M. (2000)
Stromal expression of decorin, Semaphorin6D, SPARC, Sp routy1 and Tsukushi in developing prostate and decreased levels of decorin in pr ostate cancer. (PubMed id 22880013)^{1, 3} Henke A....Thomson A.A. (2012)
Comparative analysis of gene regulation by the transc ription factor PPARalpha between mouse and human. (PubMed id 19710929)^{1, 3} Rakhshandehroo M....Kersten S. (2009)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)¹ Colland F....Gauthier J.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25987	HGNC: 28850	AceView: TSK	Ensembl:ENSG00000182704	euGenes: HUgn25987
ECgene: TSKU	H-InvDB: TSKU

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TSKU	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TSKU gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TSKU gene:
Search GeneIP for patents involving TSKU

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for TSKU (Tsukushi/TSK)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for TSKU (Tsukushi/TSK)

	Browse OriGene Antibodies		OriGene shRNA RFP for TSKU
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSKU		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSKU
	OriGene Protein Over-expression Lysate for TSKU		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TSKU		OriGene 3'-UTR Clone for TSKU
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSKU		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSKU
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TSKU		OriGene Custom Protein Services for TSKU
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSKU
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSKU
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSKU
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSKU
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSKU
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSKU

	GenScript Custom Purified and Recombinant Proteins Services for TSKU		GenScript cDNA clones with any tag delivered in your preferred vector for TSKU
	GenScript Custom Assay Services for TSKU		GenScript Custom Superior Antibodies Services for TSKU
	GenScript Custom overexpressing Cell Line Services for TSKU		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TSKU promoter
	Search Chromatin IP Primers for TSKU
	RT² qPCR Primer Assay in human, mouse, rat TSKU
	GNC Network for TSKU
	SABiosciences Custom PCR Arrays for TSKU

Search Tocris compounds for TSKU

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for TSKU
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TSKU antibodies
	TSKU proteins
	TSKU lysates

	Search for Antibodies for TSKU at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TSKU
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TSKU Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TSKU

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKU

	SwitchGear 3'UTR luciferase reporter plasmids for TSKU
	SwitchGear Promoter luciferase reporter plasmids for TSKU

ThermoFisher Antibodies for TSKU

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKU

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TSKU gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TSKU Gene

tsukushi, small leucine rich proteoglycan

Aliases
for TSKU gene

Summaries
for TSKU gene

Genomic Views
for TSKU gene

Proteins
for TSKU gene

Protein Domains /
Families
for TSKU gene

Function
for TSKU gene

Pathways & Interactions
for TSKU gene

Drugs & Compounds
for TSKU gene

Transcripts
for TSKU gene

Expression
for TSKU gene

Orthologs
for TSKU gene

Paralogs
for TSKU gene

Genomic Variants
for TSKU gene

Disorders / Diseases
for TSKU gene

Publications
for TSKU gene

External Searches for TSKU gene

Genome Databases showing TSKU gene

Other Databases showing TSKU gene

Specialized Databases showing TSKU gene

Intellectual Property
for TSKU gene

Products
for TSKU gene

View Random Gene

Advanced Search

Export list of displayed genes

TSKU Gene

tsukushi, small leucine rich proteoglycan

Aliasesfor TSKU gene

Summariesfor TSKU gene

Genomic Viewsfor TSKU gene

Proteinsfor TSKU gene

Protein Domains /Familiesfor TSKU gene

Functionfor TSKU gene

Pathways & Interactionsfor TSKU gene

Drugs & Compoundsfor TSKU gene

Transcriptsfor TSKU gene

Expression for TSKU gene

Orthologsfor TSKU gene

Paralogsfor TSKU gene

Genomic Variantsfor TSKU gene

Disorders / Diseasesfor TSKU gene

Publicationsfor TSKU gene

External Searches for TSKU gene

Genome Databases showing TSKU gene

Other Databases showing TSKU gene

Specialized Databases showing TSKU gene

Intellectual Propertyfor TSKU gene

Productsfor TSKU gene

View Random Gene

Aliases
for TSKU gene

Summaries
for TSKU gene

Genomic Views
for TSKU gene

Proteins
for TSKU gene

Protein Domains /
Families
for TSKU gene

Function
for TSKU gene

Pathways & Interactions
for TSKU gene

Drugs & Compounds
for TSKU gene

Transcripts
for TSKU gene

Expression
for TSKU gene

Orthologs
for TSKU gene

Paralogs
for TSKU gene

Genomic Variants
for TSKU gene

Disorders / Diseases
for TSKU gene

Publications
for TSKU gene

Intellectual Property
for TSKU gene

Products
for TSKU gene