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Aliases for TSKS Gene

Aliases for TSKS Gene

  • Testis Specific Serine Kinase Substrate 2 3
  • Testis-Specific Kinase Substrate 3 4
  • STK22 Substrate 1 3 4
  • STK22S1 3 4
  • TSKS1 3 4
  • Testis Specific Serine/Threonine Kinase Substrate 3
  • Protein Phosphatase 1, Regulatory Subunit 161 3
  • Testis-Specific Serine Kinase Substrate 5
  • Regulatory Subunit 161 2
  • Protein Phosphatase 1 2
  • PPP1R161 3
  • TSSKS 3

External Ids for TSKS Gene

Previous GeneCards Identifiers for TSKS Gene

  • GC19M050901
  • GC19M050611
  • GC19M054919
  • GC19M054934
  • GC19M050243
  • GC19M046619

Summaries for TSKS Gene

Entrez Gene Summary for TSKS Gene

  • This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSKS Gene

TSKS (Testis Specific Serine Kinase Substrate) is a Protein Coding gene. Diseases associated with TSKS include Mixed Germ Cell Cancer. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for TSKS Gene

  • May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSKS Gene

Genomics for TSKS Gene

Regulatory Elements for TSKS Gene

Enhancers for TSKS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSKS on UCSC Golden Path with GeneCards custom track

Genomic Location for TSKS Gene

49,739,753 bp from pter
49,763,330 bp from pter
23,578 bases
Minus strand

Genomic View for TSKS Gene

Genes around TSKS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSKS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSKS Gene

Proteins for TSKS Gene

  • Protein details for TSKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific serine kinase substrate
    Protein Accession:
    Secondary Accessions:
    • Q8WXJ0

    Protein attributes for TSKS Gene

    592 amino acids
    Molecular mass:
    65050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSKS Gene


neXtProt entry for TSKS Gene

Proteomics data for TSKS Gene at MOPED

Post-translational modifications for TSKS Gene

  • Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSKS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TSKS
  • Santa Cruz Biotechnology (SCBT) Antibodies for TSKS

No data available for DME Specific Peptides for TSKS Gene

Domains & Families for TSKS Gene

Gene Families for TSKS Gene

Protein Domains for TSKS Gene


Suggested Antigen Peptide Sequences for TSKS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSKS: view

No data available for UniProtKB/Swiss-Prot for TSKS Gene

Function for TSKS Gene

Molecular function for TSKS Gene

UniProtKB/Swiss-Prot Function:
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
genes like me logo Genes that share phenotypes with TSKS: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSKS Gene

Localization for TSKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSKS Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis.

Subcellular locations from

Jensen Localization Image for TSKS Gene COMPARTMENTS Subcellular localization image for TSKS gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TSKS Gene

Pathways & Interactions for TSKS Gene

SuperPathways for TSKS Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSKS Gene


No data available for Pathways by source and SIGNOR curated interactions for TSKS Gene

Drugs & Compounds for TSKS Gene

No Compound Related Data Available

Transcripts for TSKS Gene

mRNA/cDNA for TSKS Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSKS Gene

Testis-specific serine kinase substrate:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSKS Gene

No ASD Table

Relevant External Links for TSKS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSKS Gene

mRNA expression in normal human tissues for TSKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSKS Gene

This gene is overexpressed in Testis (x44.0).

Protein differential expression in normal tissues from HIPED for TSKS Gene

This gene is overexpressed in Testis (36.5), Ovary (16.6), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSKS Gene

SOURCE GeneReport for Unigene cluster for TSKS Gene Hs.515858

mRNA Expression by UniProt/SwissProt for TSKS Gene

Tissue specificity: Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.
genes like me logo Genes that share expression patterns with TSKS: view

Primer Products

No data available for Protein tissue co-expression partners for TSKS Gene

Orthologs for TSKS Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSKS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSKS 35
  • 87.81 (n)
  • 87.19 (a)
  • 76 (a)
(Canis familiaris)
Mammalia TSKS 35
  • 83.86 (n)
  • 81.01 (a)
  • 86 (a)
(Mus musculus)
Mammalia Tsks 35
  • 84.49 (n)
  • 85.07 (a)
Tsks 16
Tsks 36
  • 83 (a)
(Pan troglodytes)
Mammalia TSKS 35
  • 99.14 (n)
  • 98.1 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Tsks 35
  • 84.37 (n)
  • 85.42 (a)
(Monodelphis domestica)
Mammalia TSKS 36
  • 73 (a)
(Anolis carolinensis)
Reptilia TSKS 36
  • 43 (a)
Species with no ortholog for TSKS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSKS Gene

Gene Tree for TSKS (if available)
Gene Tree for TSKS (if available)

Paralogs for TSKS Gene

No data available for Paralogs for TSKS Gene

Variants for TSKS Gene

Sequence variations from dbSNP and Humsavar for TSKS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036272 A colorectal cancer sample
VAR_051459 -
rs2304202 - 49,745,244(+) GCAAG(C/T)CCCGC reference, missense
rs7259712 -- 49,745,181(+) TCCCA(C/T)GCACT intron-variant
rs67006152 -- 49,761,696(+) CGGGG(A/G)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSKS Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912269 CNV Loss 21882294
nsv470150 CNV Gain 18288195
dgv53n68 CNV Loss 17160897
esv269069 CNV Insertion 20981092

Variation tolerance for TSKS Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSKS Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSKS Gene

Disorders for TSKS Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSKS Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search TSKS in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSKS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSKS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSKS Gene

Publications for TSKS Gene

  1. Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. (PMID: 11444856) Scorilas A. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. TSKS concentrates in spermatid centrioles during flagellogenesis. (PMID: 18495105) Xu B. … Herr J.C. (Dev. Biol. 2008) 2 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3

Products for TSKS Gene

Sources for TSKS Gene