Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSKS Gene

Aliases for TSKS Gene

  • Testis Specific Serine Kinase Substrate 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 161 2 3
  • Testis-Specific Kinase Substrate 3 4
  • STK22 Substrate 1 3 4
  • STK22S1 3 4
  • TSKS1 3 4
  • Testis Specific Serine/Threonine Kinase Substrate 3
  • Testis-Specific Serine Kinase Substrate 3
  • PPP1R161 3
  • TSSKS 3

External Ids for TSKS Gene

Previous GeneCards Identifiers for TSKS Gene

  • GC19M050901
  • GC19M050611
  • GC19M054919
  • GC19M054934
  • GC19M050243
  • GC19M046619

Summaries for TSKS Gene

Entrez Gene Summary for TSKS Gene

  • This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSKS Gene

TSKS (Testis Specific Serine Kinase Substrate) is a Protein Coding gene. Diseases associated with TSKS include Mixed Germ Cell Cancer. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for TSKS Gene

  • May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSKS Gene

Genomics for TSKS Gene

Regulatory Elements for TSKS Gene

Enhancers for TSKS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F049761 1.2 Ensembl ENCODE 28.1 +1.1 1079 2.1 HDAC1 ATF1 PKNOX1 CREB3L1 RAD21 ZNF366 CREM NFYC USF2 REST TSKS ADM5 CPT1C PRMT1 PNKP PTOV1 LOC105372434
GH19F048988 1.8 FANTOM5 Ensembl ENCODE 12 +771.3 771277 7.2 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GRWD1 TEAD2 NUP62 AKT1S1 KDELR1 ENSG00000268157 SNORD35A LOC101059948 PLEKHA4 PRR12
GH19F048958 1.7 FANTOM5 ENCODE 12 +799.3 799301 10.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ENSG00000269321 NUP62 PRR12 TEAD2 PPP1R15A RUVBL2 KDELR1 PIH1D1 GRWD1 ENSG00000268157
GH19F049816 1.7 FANTOM5 Ensembl ENCODE 11.7 -55.4 -55416 5.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 PNKP TEAD2 PRR12 PLEKHA4 ENSG00000268157 ENSG00000197813 RRAS PTOV1-AS2 PTOV1 AP2A1
GH19F048977 1.5 FANTOM5 Ensembl ENCODE 11.4 +784.2 784184 2.9 PKNOX1 ATF1 SIN3A GLIS2 ZNF143 FOS SP3 JUNB TSHZ1 ZNF623 KDELR1 NUP62 SNORD35A ALDH16A1 GRWD1 SNORD35B NUCB1-AS1 TSKS NUCB1 PTOV1-AS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSKS on UCSC Golden Path with GeneCards custom track

Genomic Location for TSKS Gene

Chromosome:
19
Start:
49,739,753 bp from pter
End:
49,763,330 bp from pter
Size:
23,578 bases
Orientation:
Minus strand

Genomic View for TSKS Gene

Genes around TSKS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSKS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSKS Gene

Proteins for TSKS Gene

  • Protein details for TSKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT2-TSKS_HUMAN
    Recommended name:
    Testis-specific serine kinase substrate
    Protein Accession:
    Q9UJT2
    Secondary Accessions:
    • Q8WXJ0

    Protein attributes for TSKS Gene

    Size:
    592 amino acids
    Molecular mass:
    65050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSKS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSKS Gene

Post-translational modifications for TSKS Gene

  • Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSKS Gene

No data available for DME Specific Peptides for TSKS Gene

Domains & Families for TSKS Gene

Gene Families for TSKS Gene

Protein Domains for TSKS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSKS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSKS: view

No data available for UniProtKB/Swiss-Prot for TSKS Gene

Function for TSKS Gene

Molecular function for TSKS Gene

UniProtKB/Swiss-Prot Function:
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

Gene Ontology (GO) - Molecular Function for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15044604
GO:0019901 protein kinase binding IPI 18533145
genes like me logo Genes that share ontologies with TSKS: view
genes like me logo Genes that share phenotypes with TSKS: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSKS Gene

Localization for TSKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSKS Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSKS gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IBA --
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA,IDA 18495105
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TSKS: view

Pathways & Interactions for TSKS Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with TSKS: view

No data available for Pathways by source and SIGNOR curated interactions for TSKS Gene

Transcripts for TSKS Gene

mRNA/cDNA for TSKS Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSKS Gene

Testis-specific serine kinase substrate:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSKS Gene

No ASD Table

Relevant External Links for TSKS Gene

GeneLoc Exon Structure for
TSKS
ECgene alternative splicing isoforms for
TSKS

Expression for TSKS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSKS Gene

This gene is overexpressed in Testis (x44.0).

Protein differential expression in normal tissues from HIPED for TSKS Gene

This gene is overexpressed in Testis (36.5), Ovary (16.6), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSKS Gene



NURSA nuclear receptor signaling pathways regulating expression of TSKS Gene:

TSKS

SOURCE GeneReport for Unigene cluster for TSKS Gene:

Hs.515858

mRNA Expression by UniProt/SwissProt for TSKS Gene:

Q9UJT2-TSKS_HUMAN
Tissue specificity: Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.
genes like me logo Genes that share expression patterns with TSKS: view

Primer Products

No data available for Protein tissue co-expression partners for TSKS Gene

Orthologs for TSKS Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSKS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSKS 34 35
  • 99.14 (n)
cow
(Bos Taurus)
Mammalia TSKS 34 35
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Tsks 34 16 35
  • 84.49 (n)
rat
(Rattus norvegicus)
Mammalia Tsks 34
  • 84.37 (n)
dog
(Canis familiaris)
Mammalia TSKS 34 35
  • 83.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TSKS 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSKS 35
  • 43 (a)
OneToOne
Species where no ortholog for TSKS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSKS Gene

ENSEMBL:
Gene Tree for TSKS (if available)
TreeFam:
Gene Tree for TSKS (if available)

Paralogs for TSKS Gene

No data available for Paralogs for TSKS Gene

Variants for TSKS Gene

Sequence variations from dbSNP and Humsavar for TSKS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs149529240 A colorectal cancer sample 49,763,193(+) GTCCC(C/T)GGCCT reference, missense
rs10403659 -- 49,759,742(+) aggtg(G/T)aaaga intron-variant
rs10405296 -- 49,759,887(+) ggtgg(C/T)tcatg intron-variant
rs10405801 -- 49,745,729(+) ACCAC(G/T)CCTCT intron-variant
rs10409377 -- 49,743,237(+) ccaca(A/C)ccagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSKS Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
esv3382785 CNV insertion 20981092
esv3644627 CNV loss 21293372
nsv1109206 CNV deletion 24896259
nsv1116341 CNV deletion 24896259
nsv1160655 CNV deletion 26073780
nsv470150 CNV gain 18288195
nsv478624 CNV novel sequence insertion 20440878
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for TSKS Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSKS Gene

Human Gene Mutation Database (HGMD)
TSKS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSKS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSKS Gene

Disorders for TSKS Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSKS Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search TSKS in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSKS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSKS
genes like me logo Genes that share disorders with TSKS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSKS Gene

Publications for TSKS Gene

  1. Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. (PMID: 11444856) Scorilas A. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
  2. TSKS concentrates in spermatid centrioles during flagellogenesis. (PMID: 18495105) Xu B. … Herr J.C. (Dev. Biol. 2008) 2 3 4 64
  3. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PMID: 15044604) Hao Z. … Visconti P.E. (Mol. Hum. Reprod. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Recombinant production of enzymatically active male contraceptive drug target hTSSK2 - Localization of the TSKS domain phosphorylated by TSSK2. (PMID: 26777341) Shetty J. … Herr J.C. (Protein Expr. Purif. 2016) 3 64

Products for TSKS Gene

Sources for TSKS Gene

Content
Loading form....