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Aliases for TSKS Gene

Aliases for TSKS Gene

  • Testis-Specific Serine Kinase Substrate 2 3
  • Testis-Specific Kinase Substrate 3 4
  • STK22 Substrate 1 3 4
  • STK22S1 3 4
  • TSKS1 3 4
  • Testis Specific Serine/Threonine Kinase Substrate 3
  • Protein Phosphatase 1, Regulatory Subunit 161 3
  • Regulatory Subunit 161 2
  • Protein Phosphatase 1 2
  • PPP1R161 3
  • TSSKS 3

External Ids for TSKS Gene

Summaries for TSKS Gene

Entrez Gene Summary for TSKS Gene

  • This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSKS Gene

TSKS (Testis-Specific Serine Kinase Substrate) is a Protein Coding gene. Diseases associated with TSKS include testicular cancer. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for TSKS Gene

  • May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSKS Gene

Genomics for TSKS Gene

Genomic Location for TSKS Gene

49,739,753 bp from pter
49,763,330 bp from pter
23,578 bases
Minus strand

Genomic View for TSKS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSKS Gene

Regulatory Elements for TSKS Gene

Proteins for TSKS Gene

  • Protein details for TSKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific serine kinase substrate
    Protein Accession:
    Secondary Accessions:
    • Q8WXJ0

    Protein attributes for TSKS Gene

    592 amino acids
    Molecular mass:
    65050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSKS Gene


neXtProt entry for TSKS Gene

Proteomics data for TSKS Gene at MOPED

Post-translational modifications for TSKS Gene

  • Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSKS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSKS Gene

Domains for TSKS Gene

Protein Domains for TSKS Gene

genes like me logo Genes that share domains with TSKS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TSKS Gene

Function for TSKS Gene

Molecular function for TSKS Gene

UniProtKB/Swiss-Prot Function: May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development

Gene Ontology (GO) - Molecular Function for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15044604
GO:0019901 protein kinase binding IPI 18533145
genes like me logo Genes that share ontologies with TSKS: view

Phenotypes for TSKS Gene

GenomeRNAi human phenotypes for TSKS:
genes like me logo Genes that share phenotypes with TSKS: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSKS Gene

Localization for TSKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSKS Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis.

Subcellular locations from

Jensen Localization Image for TSKS Gene COMPARTMENTS Subcellular localization image for TSKS gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IBA --
GO:0005814 centriole IDA 18495105
genes like me logo Genes that share ontologies with TSKS: view

Pathways for TSKS Gene

SuperPathways for TSKS Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with TSKS: view

No data available for Pathways by source for TSKS Gene

Transcripts for TSKS Gene

mRNA/cDNA for TSKS Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSKS Gene

Testis-specific serine kinase substrate:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSKS Gene

No ASD Table

Relevant External Links for TSKS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSKS Gene

mRNA expression in normal human tissues for TSKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSKS Gene

This gene is overexpressed in Testis (44.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TSKS Gene

SOURCE GeneReport for Unigene cluster for TSKS Gene Hs.515858

mRNA Expression by UniProt/SwissProt for TSKS Gene

Tissue specificity: Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.
genes like me logo Genes that share expressions with TSKS: view

Orthologs for TSKS Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSKS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSKS 36
  • 99.14 (n)
  • 98.1 (a)
  • 98 (a)
(Bos Taurus)
Mammalia TSKS 36
  • 87.81 (n)
  • 87.19 (a)
  • 76 (a)
(Canis familiaris)
Mammalia TSKS 36
  • 83.86 (n)
  • 81.01 (a)
  • 86 (a)
(Mus musculus)
Mammalia Tsks 36
  • 84.49 (n)
  • 85.07 (a)
Tsks 16
Tsks 37
  • 83 (a)
(Monodelphis domestica)
Mammalia TSKS 37
  • 73 (a)
(Rattus norvegicus)
Mammalia Tsks 36
  • 84.37 (n)
  • 85.42 (a)
(Anolis carolinensis)
Reptilia TSKS 37
  • 43 (a)
Species with no ortholog for TSKS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSKS Gene

Gene Tree for TSKS (if available)
Gene Tree for TSKS (if available)

Paralogs for TSKS Gene

No data available for Paralogs for TSKS Gene

Variants for TSKS Gene

Sequence variations from dbSNP and Humsavar for TSKS Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1273633 -- 49,761,294(+) CAGGT(G/T)GGGGG intron-variant
rs1273634 -- 49,761,973(+) CGGTC(C/T)TCCCC intron-variant
rs1273635 -- 49,762,366(+) gtccc(C/T)gctgc intron-variant
rs1273636 -- 49,764,731(+) TTATC(A/C)CCAGG upstream-variant-2KB
rs1273637 -- 49,764,784(+) GGAAC(A/G)CTTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSKS Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912269 CNV Loss 21882294
nsv470150 CNV Gain 18288195
dgv53n68 CNV Loss 17160897
esv269069 CNV Insertion 20981092

Relevant External Links for TSKS Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TSKS Gene

(1) MalaCards Diseases for TSKS Gene

Search for TSKS Gene in MalaCards »
genes like me logo Genes that share disorders with TSKS: view

No data available for UniProtKB/Swiss-Prot for TSKS Gene

Publications for TSKS Gene

  1. Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. (PMID: 11444856) Scorilas A. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. TSKS concentrates in spermatid centrioles during flagellogenesis. (PMID: 18495105) Xu B. … Herr J.C. (Dev. Biol. 2008) 2 3 4
  3. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PMID: 15044604) Hao Z. … Visconti P.E. (Mol. Hum. Reprod. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for TSKS Gene

Sources for TSKS Gene

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