Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TSKS Gene

protein-coding   GIFtS: 49
GCID: GC19M050243

Testis-Specific Serine Kinase Substrate

  See TSKS-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Testis-Specific Serine Kinase Substrate1 2     STK22 Substrate 12 3
Testis-Specific Kinase Substrate2 3     TSSKS2
STK22S12 3     Testis Specific Serine/Threonine Kinase Substrate2
TSKS12 3     

External Ids:    HGNC: 307191   Entrez Gene: 603852   Ensembl: ENSG000001264677   OMIM: 6082535   UniProtKB: Q9UJT23   

Export aliases for TSKS gene to outside databases

Previous GC identifers: GC19M050901 GC19M050611 GC19M054919 GC19M054934 GC19M046619


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TSKS Gene:
This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded
protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region
19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes,
which are both involved in tumorigenesis pathways and progression. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSKS Gene:
TSKS (testis-specific serine kinase substrate) is a protein-coding gene. Diseases associated with TSKS include testicular cancer. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: TSKS_HUMAN, Q9UJT2
Function: May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid
development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSKS gene promoter:
         HOXA9   HOXA9B   Egr-1   Olf-1   Arnt   HNF-4alpha1   c-Ets-1   Meis-1b   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSKS promoter sequence
   Search Chromatin IP Primers for TSKS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSKS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

TSKS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSKS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050243:  view genomic region     (about GC identifiers)

Start:
50,243,010 bp from pter      End:
50,266,587 bp from pter
Size:
23,578 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TSKS_HUMAN, Q9UJT2 (See protein sequence)
Recommended Name: Testis-specific serine kinase substrate  
Size: 592 amino acids; 65050 Da
Secondary accessions: Q8WXJ0
Alternative splicing: 2 isoforms:  Q9UJT2-1   Q9UJT2-2   

Explore the universe of human proteins at neXtProt for TSKS: NX_Q9UJT2

Explore proteomics data for TSKS at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSKS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068379.1  
    ENSEMBL proteins: 
     ENSP00000246801   ENSP00000351691  

    TSKS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TSKS
    GenScript Custom Purified and Recombinant Proteins Services for TSKS
    Novus Biologicals TSKS Proteins
    Novus Biologicals TSKS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSKS

     
    Search eBioscience for Proteins for TSKS 

     
    antibodies-online proteins for TSKS (6 products) 

     
    antibodies-online peptides for TSKS

    TSKS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSKS
    Novus Biologicals TSKS Antibodies
    Abcam antibodies for TSKS
    Cloud-Clone Corp. Antibodies for TSKS
    ThermoFisher Antibodies for TSKS
    antibodies-online antibodies for TSKS (30 products) 

    TSKS Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSKS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSKS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSKS
    Cloud-Clone Corp. CLIAs for TSKS
    Search eBioscience for ELISAs for TSKS 
    antibodies-online kits for TSKS (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR028214 TSKS

    Graphical View of Domain Structure for InterPro Entry Q9UJT2

    ProtoNet protein and cluster: Q9UJT2


    Find genes that share domains with TSKS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSKS_HUMAN, Q9UJT2
    Function: May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid
    development

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15044604
    GO:0019901protein kinase binding IPI18533145
         
    Find genes that share ontologies with TSKS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TSKS:
     Large cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TSKS

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TSKS using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TSKS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSKS
    Predesigned siRNA for gene silencing in human, mouse, rat TSKS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSKS

    Clone
    Products:
         
    OriGene clones in human, mouse for TSKS (see all 7)
    OriGene ORF clones in mouse, rat for TSKS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSKS (NM_021733)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKS

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSKS
    Browse ESI BIO Cell Lines and PureStem Progenitors for TSKS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TSKS_HUMAN, Q9UJT2: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
    Note=Concentrates in spermatid centrioles during flagellogenesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole IDA18495105

    Find genes that share ontologies with TSKS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSKS
    Interactions:

        Search GeneGlobe Interaction Network for TSKS

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TSKS (Q9UJT21, 2, 3 ENSP000002468014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110839 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111607 I2D: score=3 STRING: ENSP00000357656
    TSSK2Q96PF21, 3, ENSP000003825444EBI-852101,EBI-852089 I2D: score=3 STRING: ENSP00000382544
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010923negative regulation of phosphatase activity IDA19389623

    Find genes that share ontologies with TSKS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSKS



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TSKS gene: 
    NM_021733.1  

    Unigene Cluster for TSKS:

    Testis-specific serine kinase substrate
    Hs.515858  [show with all ESTs]
    Unigene Representative Sequence: BC058862
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599325 ENST00000246801(uc002ppm.3) ENST00000358830
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSKS using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TSKS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSKS
    Predesigned siRNA for gene silencing in human, mouse, rat TSKS
    Clone
    Products:
         
    OriGene clones in human, mouse for TSKS (see all 7)
    OriGene ORF clones in mouse, rat for TSKS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSKS (NM_021733)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSKS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKS
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TSKS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSKS
      QuantiTect SYBR Green Assays in human, mouse, rat TSKS
      QuantiFast Probe-based Assays in human, mouse, rat TSKS

    Additional mRNA sequence: 

    AF411384.1 BC058862.1 BC114367.1 

    3 DOTS entries:

    DT.75149505  DT.95265402  DT.40111013 

    13 AceView cDNA sequences:

    BC058862 BI829980 NM_021733 BI520268 BI831872 BI827157 BI827215 BX280785 
    BX398223 AL041339 AI587014 AF411384 BI832270 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TSKS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAAAAAAA
    TSKS Expression
    About this image


    TSKS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Seminiferous Tubules
    TSKS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSKS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515858

    UniProtKB/Swiss-Prot: TSKS_HUMAN, Q9UJT2
    Tissue specificity: Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta,
    ovary and thymus

        Custom PCR Arrays for TSKS
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TSKS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSKS
    QuantiTect SYBR Green Assays in human, mouse, rat TSKS
    QuantiFast Probe-based Assays in human, mouse, rat TSKS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TSKS gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsks1 , 5 testis-specific serine kinase substrate1, 5 84.49(n)1
    85.07(a)1
      7 (29.07 cM)5
    221161  NM_011651.21  NP_035781.21 
     449432225 
    lizard
    (Anolis carolinensis)
    Reptilia TSKS6
    testis-specific serine kinase substrate
    43(a)
    1 ↔ 1
    6(80233851-80277177)


    ENSEMBL Gene Tree for TSKS (if available)
    TreeFam Gene Tree for TSKS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TSKS (see all 634)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362724
    A colorectal cancer sample4--see VAR_0362722 G R mis40--------
    rs1488492831,2
    --50242578(+) ACCACA/GACATC 1 -- ds50010--------
    rs1837833991,2
    --50242947(+) TGGGCA/TTAGAG 1 -- ds50010--------
    rs1453870531,2
    --50242977(+) CAATTC/TACTAG 1 -- ds50010--------
    rs1417268661,2
    C,F--50243103(+) TTCCCG/ATGGAC 2 /T /M mis11Minor allele frequency- A:0.00NA 4552
    rs617349961,2
    C,F--50243120(+) AGTGGC/GAGGTT 2 L syn13Minor allele frequency- G:0.02NS WA NA 4720
    rs2006856091,2
    C--50243138(+) TGATCG/ATGGAG 2 /H syn11Minor allele frequency- A:0.00EU 1323
    rs2012500461,2
    --50243147(+) AGGGAC/GCACAT 2 C W mis10--------
    rs794858061,2
    C,F--50243171(+) TGGTCC/TAGAGT 2 L syn13Minor allele frequency- T:0.01NA EU 5993
    rs1167814311,2
    C--50243197(+) GTCATG/TAGGCA 1 -- int11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for TSKS (50243010 - 50266587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TSKS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269069CNV Insertion20981092
    nsv912269CNV Loss21882294
    dgv53n68CNV Loss17160897
    nsv470150CNV Gain18288195
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSKS
    DNA2.0 Custom Variant and Variant Library Synthesis for TSKS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608253    OMIM disorders: --

    1 disease for TSKS:    
    About MalaCards
    testicular cancer


    Find genes that share disorders with TSKS           About GenesLikeMe


    Export disorders for TSKS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TSKS gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TSKS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. (PubMed id 11444856)1, 2, 3, 9 Scorilas A....Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001)
    2. TSKS concentrates in spermatid centrioles during flagellogenesis. (PubMed id 18495105)1, 2, 3 Xu B.... Herr J.C. (Dev. Biol. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 2 Hao Z....Visconti P.E. (Mol. Hum. Reprod. 2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (Chem. Biol. 2009)
    8. Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. (PubMed id 18533145)1 Xu B.... Herr J.C. (Dev. Biol. 2008)
    9. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 60385 HGNC: 30719 AceView: TSKS Ensembl:ENSG00000126467 euGenes: HUgn60385
    ECgene: TSKS H-InvDB: TSKS

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TSKS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TSKS gene:
    Search GeneIP for patents involving TSKS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSKS  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TSKS  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSKS   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TSKS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSKS   OriGene Custom Protein Services for TSKS  

     
     
     Block miRNA regulation of human, mouse, rat TSKS using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TSKS
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSKS Predesigned siRNA for gene silencing in human, mouse, rat TSKS
     QuantiFast Probe-based Assays in human, mouse, rat TSKS QuantiTect SYBR Green Assays in human, mouse, rat TSKS
     Custom PCR Arrays for TSKS Search Chromatin IP Primers for TSKS
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSKS  Search GeneGlobe Interaction Network for TSKS
     Regulatory tfbs in TSKS promoter
     GenScript Custom Purified and Recombinant Proteins Services for TSKS GenScript cDNA clones with any tag delivered in your preferred vector for TSKS
     GenScript Custom Assay Services for TSKS GenScript Custom overexpressing Cell Line Services for TSKS
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TSKS
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TSKS antibodies
     TSKS proteins
     TSKS lysates
     Antibodies for TSKS
     See all of Abcam's Antibodies, Kits and Proteins for TSKS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TSKS
     Antibodies for TSKS
     ELISAs for TSKS
     CLIAs for TSKS



     Browse ESI BIO Cell Lines and PureStem Progenitors for TSKS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKS
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TSKS
     SwitchGear Promoter luciferase reporter plasmids for TSKS
     ThermoFisher Antibodies for TSKS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKS
     Browse compounds at ApexBio
     Search Addgene for plasmids for TSKS
      Search eBioscience for proteins for TSKS
      Search eBioscience for elisas for TSKS
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TSKS
     antibodies-online antibodies for TSKS (30 products)
     antibodies-online kits for TSKS (6 products)
     antibodies-online peptides for TSKS
     antibodies-online proteins for TSKS (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSKS gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4