TSKS Gene
protein-coding GIFtS: 47
GCID: GC19M050243
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testis-specific serine kinase substrate
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Aliases
for TSKS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis-Specific Serine Kinase Substrate1 2 | | TSKS12 3 | | TSSKS1 2 | | STK22 Substrate 12 3 | | Testis-Specific Kinase Substrate2 3 | | Testis Specific Serine/Threonine Kinase Substrate2 | | STK22S12 3 | | |
Export aliases for TSKS gene to outside databasesPrevious GC identifers: GC19M050901 GC19M050611 GC19M054919 GC19M054934 GC19M046619 |
Summaries
for TSKS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSKS:
This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encodedprotein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are bothinvolved in tumorigenesis pathways and progression. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TSKS_HUMAN, Q9UJT2Function: May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatiddevelopment
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Genomic Views
for TSKS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSKS gene promoter:
HOXA9 HOXA9B Egr-1 Olf-1 Arnt HNF-4alpha1 c-Ets-1 Meis-1b Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSKS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSKS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3TSKS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M050243: view genomic region
(about GC identifiers)
Start:
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50,243,011 bp from pter |
End:
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50,266,543 bp from pter |
Size:
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23,533 bases |
Orientation:
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minus strand |
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Proteins
for TSKS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSKS_HUMAN, Q9UJT2 (See
protein sequence)Recommended Name: Testis-specific serine kinase substrate Size: 592 amino acids; 65050 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Concentrates in spermatid centrioles duringflagellogenesis
Secondary accessions: Q8WXJ0Alternative splicing: 2 isoforms: Q9UJT2-1 Q9UJT2-2 Explore the universe of human proteins at neXtProt for TSKS: NX_Q9UJT2
Post-translational modifications:
Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UJT2
TSKS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068379.1
ENSEMBL proteins: ENSP00000246801 ENSP00000351691
Human Recombinant Protein Products for TSKS:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TSKS for ontologies About GeneDecksing
TSKS Antibody Products:
Assay Products for TSKS: |
Protein
Domains /
Families
for TSKS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9UJT2 |
Function
for TSKS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TSKS_HUMAN, Q9UJT2Function: May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatiddevelopment Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TSKS for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TSKS:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSKS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSKS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSKS (NM_021733) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSKS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKS |
|
Pathways & Interactions
for TSKS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSKS
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for TSKS (Q9UJT21, 2, 3 ENSP000002468014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010923 | negative regulation of phosphatase activity |
IDA | 19389623 |
TSKS for ontologies About GeneDecksing
|
Drugs & Compounds
for TSKS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSKS
Search CenterWatch for drugs/clinical trials and news about TSKS
|
Transcripts
for TSKS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSKS gene: NM_021733.1 Unigene Cluster for TSKS: Testis-specific serine kinase substrate Hs.515858 [show with all ESTs]Unigene Representative Sequence: BC0588622 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000246801(uc002ppm.3) ENST00000358830
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSKS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSKS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSKS (NM_021733) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSKS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKS |
Additional cDNA sequence: AF411384.1 BC058862.1 BC114367.1 3 DOTS entries: DT.75149505 DT.95265402 DT.40111013 13 AceView cDNA sequences: BI829980 NM_021733 BC058862 AF411384 AI587014 BI831872 BI827215 BX280785 BI827157 BI520268 BX398223 AL041339 BI832270
GeneLoc Exon Structure
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Expression
for TSKS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSKS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAAAAAAA
About this image
See TSKS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSKS
SOURCE GeneReport for Unigene cluster: Hs.515858
UniProtKB/Swiss-Prot: TSKS_HUMAN, Q9UJT2Tissue specificity: Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary andthymus
SABiosciences Custom PCR Arrays for TSKS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSKS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSKS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSKS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSKS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKS |
Orthologs
for TSKS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TSKS gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for TSKS (if available)
TreeFam Gene Tree for TSKS (if available) |
Paralogs
for TSKS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TSKS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSKS (50243011 - 50266543 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TSKS
2 CNVs: 5114 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSKS |
|
Disorders
/ Diseases
for TSKS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSKS for disorders About GeneDecksing
OMIM gene information: 608253
OMIM disorders: --
4  diseases for TSKS: About MalaCardstesticular cancer male infertility infertility prostatitis
Export disorders for TSKS gene to outside databases
|
Publications
for TSKS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSKS gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TSKS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. (PubMed id 11444856)1, 2, 3, 9 Scorilas A....Diamandis E.P. (2001)
- TSKS concentrates in spermatid centrioles during flagellogenesis. (PubMed id 18495105)1, 2, 3 Xu B....Herr J.C. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 2 Hao Z....Visconti P.E. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)1 Hendrickx A.... Bollen M. (2009)
- Targeted deletion of Tssk1 and 2 causes male infertil ity due to haploinsufficiency. (PubMed id 18533145)1 Xu B....Herr J.C. (2008)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
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External Searches for TSKS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TSKS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSKS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSKS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSKS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSKS gene:
Search GeneIP for patents involving TSKS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSKS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSKS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSKS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSKS | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSKS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSKS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSKS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for TSKS |
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 | | | TSKS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSKS |
|  |  |  |  | | | | ThermoFisher Antibodies for TSKS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSKS |
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