Aliases
for TSIX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 2
| Aliases |
|---|
| TSIX Transcript, XIST Antisense RNA1 2 | | TSIX Transcript, XIST Antisense RNA (Non-Protein Coding)1 | | LINC000131 2 | | X (Inactive)-Specific Transcript, Antisense1 | | NCRNA000131 2 | | XIST-AS2 | | XIST-AS11 2 | | XISTAS2 |
| External Ids: | HGNC: 123771 | Entrez Gene: 93832 | OMIM: 3001815 | | ORGUL members: | |
|---|
| NONCODE:n385783 | |
Export aliases for TSIX gene to outside databasesPrevious GC identifer: GC0XU990273
|---|
Summaries
for TSIX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSIX:
In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by theX-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisensetranscript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. Themouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xistthrough modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivationdoes not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression oraffect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend overmore than 30 kb, but its exact nature has not been determined. (provided by RefSeq, Jul 2008)
|
Genomic Views
for TSIX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSIX gene promoter:
Cart-1 CUTL1 Cdc5
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSIX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSIX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.2 HGNC cytogenetic band: Xq13.2TSIX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP073013: view genomic region
(about GC identifiers)
Start:
|
73,012,040 bp from pter |
End:
|
73,049,066 bp from pter |
Size:
|
37,027 bases |
Orientation:
|
plus strand |
|
Proteins
for TSIX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for TSIX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for TSIX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
Genatlas biochemistry entry for TSIX:gene antisense to XIST,involved in the early steps of X-inactivation
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TSIX | |  | Search LifeMap BioReagents cell lines for TSIX | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSIX |
Pathways & Interactions
for TSIX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSIX
|
Drugs & Compounds
for TSIX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSIX
Search CenterWatch for drugs/clinical trials and news about TSIX 
|
Transcripts
for TSIX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
GeneLoc Exon Structure
|
Expression
for TSIX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for TSIX:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for TSIX
SABiosciences Custom PCR Arrays for TSIX
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSIX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TSIX | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSIX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSIX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSIX |
Orthologs
for TSIX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
|
Paralogs
for TSIX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TSIX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSIX (73012040 - 73049066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSIX: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TSIX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSIX for disorders About GeneDecksing
OMIM gene information: 300181
OMIM disorders: --
3  diseases for TSIX: About MalaCardsx inactivation embryonal carcinoma carcinoma
Export disorders for TSIX gene to outside databases
|
Publications
for TSIX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSIX gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TSIX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tsix, a gene antisense to Xist at the X-inactivation centre. (PubMed id 10192391)1, 3, 9 Lee J.T....Warshawsky D. (1999)
- CTCF, a candidate trans-acting factor for X-inactivation choice. (PubMed id 11743158)1, 9 Chao W.... Lee J.T. (2002)
- Is Tsix repression of Xist specific to mouse? (PubMed id 12610550)1 Migeon B.R. (2003)
- Species differences in TSIX/Tsix reveal the roles of these genes in X-chromosome inactivation. (PubMed id 12023758)1 Migeon B.R....Carpenter H. (2002)
- Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: implications for X inactivation. (PubMed id 11555794)1 Migeon B.R....McIntosh I. (2001)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
- Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)
- Characterization and quantitation of differential Tsix transcripts: implications for Tsix function. (PubMed id 12499393)9 Shibata S. and Lee J.T. (2003)
- A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. (PubMed id 11481444)9 Stavropoulos N....Lee J.T. (2001)
- Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice. (PubMed id 15458646)9 Shibata S. and Lee J.T. (2004)
|
External Searches for TSIX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSIX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSIX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSIX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSIX | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSIX gene:
Search GeneIP for patents involving TSIX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSIX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSIX | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSIX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSIX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSIX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSIX | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSIX |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TSIX |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSIX |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TSIX |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TSIX |
| |  | |
|
|
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