Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSHZ3 Gene

protein-coding   GIFtS: 49
GCID: GC19M031765

teashirt zinc finger homeobox 3

(Previous names: zinc finger protein 537, teashirt family zinc finger 3...)
(Previous symbol: ZNF537)
 Explore 3 diseases affiliated with
TSHZ3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TSHZ3    

Aliases
for TSHZ3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Teashirt Zinc Finger Homeobox 31 2     Teashirt Family Zinc Finger 31 2
Zinc Finger Protein 5371 2 3     KIAA14741 3
TSH31 2 3     Teashirt 32
ZNF5371 2 3     Teashirt Homolog 32

External Ids:    HGNC: 307001   Entrez Gene: 576162   Ensembl: ENSG000001212977   OMIM: 6141195   UniProtKB: Q63HK53   

Export aliases for TSHZ3 gene to outside databases

Previous GC identifers: GC19M036458 GC19M028269


Summaries
for TSHZ3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5
Function: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and
HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription
repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region
surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory
rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway
function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in
the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the
up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter

Gene Wiki entry for TSHZ3


Genomic Views
for TSHZ3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSHZ3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSHZ3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSHZ3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSHZ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q13.11

TSHZ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHZ3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M031765:  view genomic region     (about GC identifiers)

Start:
 31,765,851 bp from pter      End:
 31,840,453 bp from pter
Size:
 74,603 bases      Orientation:
 minus strand

Proteins
for TSHZ3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5 (See protein sequence)
Recommended Name: Teashirt homolog 3  
Size: 1081 amino acids; 118566 Da
Subunit: Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and
HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and
APBB1 is mediated by TSHZ3
Subcellular location: Nucleus. Cell projection, growth cone (By similarity). Note=Colocalizes with APBB1 in axonal
growth cone (By similarity). Colocalizes with APBB1 in the nucleus
Developmental stage: Expressed in peri-urothelial cells of the proximal ureter and renal pelvis at 9 weeks of gestation
Sequence caution: Sequence=CAB66739.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TSHZ3:
2DMI (3D)    
Secondary accessions: Q9H0G6 Q9P254

Explore the universe of human proteins at neXtProt for TSHZ3: NX_Q63HK5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q63HK5

    • TSHZ3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065907.2  
    ENSEMBL proteins: 
     ENSP00000240587  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TSHZ3 
    GenScript Custom Purified and Recombinant Proteins Services for TSHZ3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TSHZ3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19343227
    GO:0005739mitochondrion IEA--
    GO:0030426growth cone IEA--


    TSHZ3 for ontologies           About GeneDecksing



    TSHZ3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSHZ3 
    GenScript Custom Superior Antibodies Services for TSHZ3
    Novus Biologicals TSHZ3 Antibody
    Search for Antibodies for TSHZ3 at Abcam  
    Uscn Antibodies for TSHZ3
    Search ThermoFisher Antibodies for TSHZ3

    Assay Products for TSHZ3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSHZ3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TSHZ3

    Protein Domains /
    Families
    for TSHZ3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TSHZ3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR026810 Tshz3
     IPR027008 Teashirt_fam
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q63HK5

    ProtoNet protein and cluster: Q63HK5

    UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5
    Similarity: Belongs to the teashirt C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for TSHZ3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5
    Function: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and
    HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription
    repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region
    surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory
    rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway
    function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in
    the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the
    up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter

    miRNA
    Products:            		miRTarBase miRNAs that target TSHZ3:
    hsa-mir-155 (MIRT004604)

    OriGene 3'-UTR Clone: TSHZ3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSHZ3
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate TSHZ3 (see all 105):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-485-3p hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmid: TSHZ3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSHZ3 (see all 7)
    OriGene shRNA RFP: TSHZ3
    OriGene siRNA: TSHZ3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHZ3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TSHZ3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSHZ3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSHZ3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TSHZ3 (NM_020856)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHZ3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHZ3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TSHZ3
    Search LifeMap BioReagents cell lines for TSHZ3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ3

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA19343227
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI19343227
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    TSHZ3 for ontologies           About GeneDecksing


    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tshz3):
     behavior/neurological  integument  mortality/aging  renal/urinary system  respiratory system 

    TSHZ3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TSHZ3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSHZ3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TSHZ3 (Q63HK53 ENSP000002405874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002133, ENSP000002994024I2D: score=1 STRING: ENSP00000299402
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0001657ureteric bud development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0002087regulation of respiratory gaseous exchange by neurological system process ISS--
    GO:0006351transcription, DNA-dependent IEA--


    TSHZ3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TSHZ3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSHZ3
    Search CenterWatch for drugs/clinical trials and news about TSHZ3 / TSH3 

    Transcripts
    for TSHZ3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSHZ3 gene: 
    NM_020856.2  

    Unigene Cluster for TSHZ3:

    Teashirt zinc finger homeobox 3
    Hs.278436  [show with all ESTs]
    Unigene Representative Sequence: NM_020856
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240587(uc002nsy.4) ENST00000560707 ENST00000558569

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TSHZ3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSHZ3
    8/105 QIAGEN miScript miRNA Assays for microRNAs that regulate TSHZ3 (see all 105):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-485-3p hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmid: TSHZ3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSHZ3 (see all 7)
    OriGene shRNA RFP: TSHZ3
    OriGene siRNA: TSHZ3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHZ3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSHZ3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSHZ3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TSHZ3 (NM_020856)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHZ3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHZ3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSHZ3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSHZ3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHZ3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHZ3

    Additional cDNA sequence: 

    AB040907.1 AK291466.1 AK293267.1 AL136805.1 BC127095.1 BC127096.1 BX648745.1 

    3 DOTS entries:

    DT.310254  DT.75114252  DT.121463523 

    24/101 AceView cDNA sequences (see all 101):

    AL136805 D80947 AI582568 N70608 BX648745 BQ100745 BP378244 AI151043 
    AI540495 BG826712 BM722326 AL535086 CK823073 CR626691 W04928 AW183880 
    AI151039 CA447401 D80963 CA392895 AB040907 NM_020856 C14727 BQ884089 

    GeneLoc Exon Structure


    Expression
    for TSHZ3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSHZ3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TSHZ3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    KidneyInterstitial StromaKidney
    KidneyMetanephrosKidney
    Lower Urinary TractUreterLower Urinary Tract
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TSHZ3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSHZ3

    SOURCE GeneReport for Unigene cluster: Hs.278436

    UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5
    Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease

        SABiosciences Custom PCR Arrays for TSHZ3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSHZ3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSHZ3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHZ3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHZ3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ3

    Orthologs
    for TSHZ3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TSHZ3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tshz31 , 5 teashirt zinc finger family member 31, 5 88.5(n)1
    95.1(a)1    		   7 (22.79 cM)5
    2439311  NM_172298.21  NP_758502.11 
     366981185 
    chicken
    (Gallus gallus)    		 Aves TSHZ31 teashirt zinc finger homeobox 3 79.3(n)
    92.12(a)    		   415762  XM_414125.2  XP_414125.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TSHZ36
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343299.1(294577-297780)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.90222 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_005777.2 (H.sapiens) serologically defined colon cancer antigen 33 [Homo sapiens] less 79.53(n)    BG579545.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tshz3b1 teashirt zinc finger homeobox 3b 71.02(n)
    75.9(a)    		   565811  NM_001195407.1  NP_001182336.1 


    ENSEMBL Gene Tree for TSHZ3 (if available)
    TreeFam Gene Tree for TSHZ3 (if available) 

    Paralogs
    for TSHZ3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSHZ3 gene
    TSHZ12  TSHZ22  
    2 SIMAP similar genes for TSHZ3 using alignment to 2 protein entries:     TSH3_HUMAN (see all proteins):
    TSHZ1    TSHZ2

    TSHZ3 for paralogs           About GeneDecksing



    Genomic Variants
    for TSHZ3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1236 NCBI SNPs in TSHZ3 are shown (see all 1236)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1397966971,2
    		--31765388(+) TTTCCC/TGCTGT 1 -- int10--------
    rs581379321,2
    		C,--31765464(+) GACAGT/CGCAGG 1 -- int12Minor allele frequency- C:0.17CSA WA 119
    rs2014053141,2
    		--31765481(+) ACCCC-/GGGGCA 1 -- int10--------
    rs1497592561,2
    		--31765595(+) AACCTC/TATAGG 1 -- int10--------
    rs1864076881,2
    		--31765632(+) ATTCTC/TGGTGC 1 -- int10--------
    rs1908125081,2
    		--31765671(+) GTGCTC/TCCTGC 1 -- int10--------
    rs1172121431,2
    		F,--31765685(+) CCAAAC/TGCCAA 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1446833081,2
    		--31765750(+) CAGCCA/GCAGCA 1 -- int10--------
    rs1485833541,2
    		--31765874(+) TTTAAC/TGCTGC 1 -- ut310--------
    rs1429999761,2
    		--31766346(+) TTTTTG/TTTGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TSHZ3 (31765851 - 31840453 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TSHZ3
         1 Indel: 73349

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSHZ3
    DNA2.0 Custom Variant and Variant Library Synthesis for TSHZ3

    Disorders / Diseases
    for TSHZ3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TSHZ3 for disorders           About GeneDecksing

    OMIM gene information: 614119    OMIM disorders: --

    3 diseases for TSHZ3:    About MalaCards
    hydronephrosis    alzheimer's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TSHZ3:
    Hydronephrosis
    Human Genome Epidemiology (HuGE) Navigator: TSHZ3 (2 documents)

    Export disorders for TSHZ3 gene to outside databases

    Publications
    for TSHZ3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSHZ3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TSHZ3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi -ureteric junction obstruction. (PubMed id 19745106)1, 2 Jenkins D....Woolf A.S. (2010)
    2. FE65 binds Teashirt, inhibiting expression of the pri mate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y....Buxbaum J.D. (2009)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    5. Teashirt-3, a novel regulator of muscle differentiati on, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression. (PubMed id 21543328)1 Faralli H....Fasano L. (2011)
    6. Genetic loci associated with plasma phospholipid n-3 f atty acids: a meta-analysis of genome-wide association studies from the CHARGE C onsortium. (PubMed id 21829377)1 Lemaitre R.N....Steffen L.M. (2011)
    7. Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and p rostate cancers. (PubMed id 21423795)1 Yamamoto M....Yamamoto F. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1 Need A.C....Goldstein D.B. (2009)

    External Searches for TSHZ3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TSHZ3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57616 HGNC: 30700 AceView: ZNF537 Ensembl:ENSG00000121297 euGenes: HUgn57616
    ECgene: TSHZ3 H-InvDB: TSHZ3

    Other Databases showing TSHZ3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1474

    Specialized Databases showing TSHZ3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSHZ3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt122.shtml

    Intellectual Property
    for TSHZ3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TSHZ3 gene:
    Search GeneIP for patents involving TSHZ3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TSHZ3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TSHZ3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSHZ3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSHZ3  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TSHZ3   OriGene 3'-UTR Clone for TSHZ3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSHZ3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSHZ3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSHZ3   OriGene Custom Protein Services for TSHZ3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSHZ3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSHZ3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSHZ3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHZ3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHZ3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHZ3
     GenScript Custom Purified and Recombinant Proteins Services for TSHZ3 GenScript cDNA clones with any tag delivered in your preferred vector for TSHZ3
     GenScript Custom Assay Services for TSHZ3 GenScript Custom Superior Antibodies Services for TSHZ3
     GenScript Custom overexpressing Cell Line Services for TSHZ3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSHZ3 promoter
     Search Chromatin IP Primers for TSHZ3
     RT2 qPCR Primer Assay in human, mouse, rat TSHZ3
     Search GNC Networks for TSHZ3
     SABiosciences Custom PCR Arrays for TSHZ3
     Search Tocris compounds for TSHZ3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSHZ3 antibodies
     Search for Antibodies for TSHZ3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TSHZ3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TSHZ3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TSHZ3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ3
     SwitchGear 3'UTR luciferase reporter plasmids for TSHZ3
     SwitchGear Promoter luciferase reporter plasmids for TSHZ3
     Search ThermoFisher Antibodies for TSHZ3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHZ3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TSHZ3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4