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TSHZ3 Gene

protein-coding   GIFtS: 51
GCID: GC19M031765

Teashirt Zinc Finger Homeobox 3

(Previous names: zinc finger protein 537, teashirt family zinc finger 3)
(Previous symbol: ZNF537)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Teashirt Zinc Finger Homeobox 31 2     Teashirt 31 2
Zinc Finger Protein 5371 2 3     TSH32 3
ZNF5371 2 3     KIAA14743 5
Teashirt Family Zinc Finger 31 2     Teashirt Homolog 32

External Ids:    HGNC: 307001   Entrez Gene: 576162   Ensembl: ENSG000001212977   OMIM: 6141195   UniProtKB: Q63HK53   

Export aliases for TSHZ3 gene to outside databases

Previous GC identifers: GC19M036458 GC19M028269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSHZ3 Gene:
TSHZ3 (teashirt zinc finger homeobox 3) is a protein-coding gene. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TSHZ1.

UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5
Function: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET
and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated
transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with
chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons
involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA)
motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity
compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells
during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth
muscle cells in the proximal ureter

Gene Wiki entry for TSHZ3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSHZ3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSHZ3 promoter sequence
   Search Chromatin IP Primers for TSHZ3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSHZ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q13.11

TSHZ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHZ3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M031765:  view genomic region     (about GC identifiers)

Start:
31,765,851 bp from pter      End:
31,840,453 bp from pter
Size:
74,603 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5 (See protein sequence)
Recommended Name: Teashirt homolog 3  
Size: 1081 amino acids; 118566 Da
Subunit: Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and
HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1
and APBB1 is mediated by TSHZ3
Developmental stage: Expressed in peri-urothelial cells of the proximal ureter and renal pelvis at 9 weeks of
gestation
Sequence caution: Sequence=CAB66739.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TSHZ3:
2DMI (3D)    
Secondary accessions: Q9H0G6 Q9P254

Explore the universe of human proteins at neXtProt for TSHZ3: NX_Q63HK5

Explore proteomics data for TSHZ3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSHZ3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065907.2  
    ENSEMBL proteins: 
     ENSP00000240587   ENSP00000475888   ENSP00000475613  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class
    TSHZ: Teashirt zinc fingers
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR027008 Teashirt_fam
     IPR015880 Znf_C2H2-like
     IPR026810 Tshz3
     IPR001356 Homeobox_dom
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q63HK5

    ProtoNet protein and cluster: Q63HK5

    UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5
    Similarity: Belongs to the teashirt C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with TSHZ3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSH3_HUMAN, Q63HK5
    Function: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET
    and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated
    transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with
    chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons
    involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA)
    motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity
    compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells
    during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth
    muscle cells in the proximal ureter

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IDA19343227
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI19343227
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with TSHZ3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tshz3):
     behavior/neurological  integument  mortality/aging  renal/urinary system  respiratory system 

    Find genes that share phenotypes with TSHZ3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TSHZ3

    miRNA
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    miRTarBase miRNAs that target TSHZ3:
    hsa-mir-155-5p (MIRT004604), hsa-mir-25-3p (MIRT050311), hsa-mir-21-5p (MIRT030966), hsa-mir-30b-5p (MIRT046112)

    Block miRNA regulation of human, mouse, rat TSHZ3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSHZ3 (see all 105):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-485-3p hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidTSHZ3 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat TSHZ3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSH3_HUMAN, Q63HK5: Nucleus. Cell projection, growth cone (By similarity). Note=Colocalizes with APBB1 in axonal
    growth cone (By similarity). Colocalizes with APBB1 in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IEA--
    GO:0030426growth cone IEA--

    Find genes that share ontologies with TSHZ3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSHZ3
    Interactions:

        Search GeneGlobe Interaction Network for TSHZ3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TSHZ3 (Q63HK53 ENSP000002405874) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002133, ENSP000002994024I2D: score=1 STRING: ENSP00000299402
    SPENENSP000003649124STRING: ENSP00000364912
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    JUPENSP000003111134STRING: ENSP00000311113
    MEIS1ENSP000002723694STRING: ENSP00000272369
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0001657ureteric bud development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0002087regulation of respiratory gaseous exchange by neurological system process ISS--
    GO:0006351transcription, DNA-templated IEA--

    Find genes that share ontologies with TSHZ3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSHZ3 (TSH3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSHZ3 gene: 
    NM_020856.2  

    Unigene Cluster for TSHZ3:

    Teashirt zinc finger homeobox 3
    Hs.278436  [show with all ESTs]
    Unigene Representative Sequence: NM_020856
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240587(uc002nsy.4) ENST00000560707 ENST00000558569
    miRNA
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    Block miRNA regulation of human, mouse, rat TSHZ3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSHZ3 (see all 105):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-485-3p hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidTSHZ3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TSHZ3
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    GenScript: all cDNA clones in your preferred vector: TSHZ3 (NM_020856)
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      QuantiTect SYBR Green Assays in human, mouse, rat TSHZ3
      QuantiFast Probe-based Assays in human, mouse, rat TSHZ3

    Additional mRNA sequence: 

    AB040907.1 AK291466.1 AK293267.1 AL136805.1 BC127095.1 BC127096.1 BX648745.1 

    3 DOTS entries:

    DT.310254  DT.75114252  DT.121463523 

    Selected AceView cDNA sequences (see all 101):

    BQ100745 AI453463 BQ884089 BX648745 C14727 BP364279 AW183880 NM_020856 
    AB040907 N70608 AI582568 D80947 AL136805 CA447401 D80963 CA392895 
    W04928 CK823073 AI151039 AI540495 AI151043 AL535086 BG826712 CR626691 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSHZ3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSHZ3 Expression
    About this image


    TSHZ3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Natural Killer Cells Peripheral Blood
             Umbilical cord blood-derived mesenchymal stem cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    TSHZ3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSHZ3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278436

    UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5
    Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TSHZ3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tshz31 , 5 teashirt zinc finger family member 31, 5 88.5(n)1
    95.1(a)1
      7 (22.79 cM)5
    2439311  NM_172298.21  NP_758502.11 
     366981185 
    chicken
    (Gallus gallus)
    Aves TSHZ31 teashirt zinc finger homeobox 3 79.3(n)
    92.12(a)
      415762  XM_414125.3  XP_414125.3 
    lizard
    (Anolis carolinensis)
    Reptilia TSHZ36
    teashirt zinc finger homeobox 3
    90(a)
    1 ↔ 1
    GL343299.1(152218-301191)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.90222 Xenopus laevis transcribed sequence with moderate similarity more 79.53(n)    BG579545.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tshz3b1 teashirt zinc finger homeobox 3b 71.05(n)
    75.9(a)
      565811  NM_001195407.1  NP_001182336.1 


    ENSEMBL Gene Tree for TSHZ3 (if available)
    TreeFam Gene Tree for TSHZ3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSHZ3 gene
    TSHZ12  TSHZ22  
    2 SIMAP similar genes for TSHZ3 using alignment to 4 protein entries:     TSH3_HUMAN (see all proteins):
    TSHZ1    TSHZ2

    Find genes that share paralogs with TSHZ3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSHZ3 (see all 1561)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917753781,2
    --28345928(+) CACCCA/GCACGG 1 -- us2k10--------
    rs1458297621,2
    --28345937(+) GGTAAA/GATCAA 1 -- us2k10--------
    rs621026241,2
    F--28345950(+) GTCTCG/CGCTCG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs621026251,2
    F--28346137(+) TCGGGG/CTGGCG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1179025281,2
    C,F--28346229(+) CGCGGC/TCGTGG 1 -- us2k12Minor allele frequency- T:0.26NA EA 240
    rs1160003631,2
    F--28346348(+) CGCCGC/TACGGG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs81046091,2
    C,F--28346350(+) CCGCAC/TGGGGT 1 -- us2k12Minor allele frequency- T:0.19WA 120
    rs1397966971,2
    --31765388(+) TTTCCC/TGCTGT 1 -- int10--------
    rs581379321,2
    C,F--31765464(+) GACAGT/CGCAGG 1 -- int12Minor allele frequency- C:0.17CSA WA 119
    rs2014053141,2
    --31765481(+) ACCCC-/GGGGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TSHZ3 (31765851 - 31840453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TSHZ3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718454CNV Deletion23290073
    esv25402CNV Loss19812545
    nsv510764CNV Loss20534489
    nsv911571CNV Loss21882294
    nsv828522CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614119    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TSHZ3:
    Hydronephrosis

    Find genes that share disorders with TSHZ3           About GenesLikeMe

    Genetic Association Database (GAD): TSHZ3
    Human Genome Epidemiology (HuGE) Navigator: TSHZ3 (2 documents)

    Export disorders for TSHZ3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSHZ3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TSHZ3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. (PubMed id 19745106)1, 2, 4 Jenkins D.... Woolf A.S. (Nephrol. Dial. Transplant. 2010)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    4. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y.... Buxbaum J.D. (PLoS ONE 2009)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. TSHZ3 and SOX9 regulate the timing of smooth muscle cell differentiation in the ureter by reducing myocardin activity. (PubMed id 23671695)1 Martin E....Fasano L. (PLoS ONE 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression. (PubMed id 21543328)1 Faralli H....Fasano L. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57616 HGNC: 30700 AceView: ZNF537 Ensembl:ENSG00000121297 euGenes: HUgn57616
    ECgene: TSHZ3 H-InvDB: TSHZ3

    (According to HUGE)
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    HUGE: KIAA1474

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSHZ3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/122

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSHZ3 gene:
    Search GeneIP for patents involving TSHZ3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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