Aliases for TSHZ3 Gene
External Ids for TSHZ3 Gene
Previous HGNC Symbols for TSHZ3 Gene
Previous GeneCards Identifiers for TSHZ3 Gene
GeneCards Summary for TSHZ3 Gene
TSHZ3 (Teashirt Zinc Finger Homeobox 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is TSHZ1.
UniProtKB/Swiss-Prot for TSHZ3 Gene
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.