TSHZ3 Gene
protein-coding GIFtS : 49 GCID: GC19 M031765
teashirt zinc finger homeobox 3 zinc finger protein 537, teashirt family zinc finger 3... ZNF537 )
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Aliasesfor TSHZ3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Teashirt Zinc Finger Homeobox 3 1 2 Teashirt Family Zinc Finger 31 2 Zinc Finger Protein 5371 2 3 KIAA14741 3 TSH31 2 3 Teashirt 32 ZNF5371 2 3 Teashirt Homolog 32
Export aliases for TSHZ3 gene to outside databases Previous GC identifers: GC19M036458 GC19M028269
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Summariesfor TSHZ3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5 Function : Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET andHDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter Gene Wiki entry for TSHZ3
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Genomic Viewsfor TSHZ3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TSHZ3 gene promoter:E2F-3a E2F-4 E2F-5 E2F E2F-1 E2F-2 Other transcription factors Search SABiosciences Chromatin IP Primers for TSHZ3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q12 Ensembl cytogenetic band: 19q12 HGNC cytogenetic band: 19q13.11 TSHZ3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M031765: view genomic region
(about GC identifiers )
Start: 31,765,851 bp from pter End:
31,840,453 bp from pter
Size: 74,603 bases Orientation:
minus strand
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Proteinsfor TSHZ3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5 See
protein sequence )Recommended Name: Size : 1081 amino acids; 118566 DaSubunit : Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 andHDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3
Subcellular location : Nucleus. Cell projection, growth cone (By similarity). Note=Colocalizes with APBB1 in axonalgrowth cone (By similarity). Colocalizes with APBB1 in the nucleus
Developmental stage : Expressed in peri-urothelial cells of the proximal ureter and renal pelvis at 9 weeks of gestationSequence caution : Sequence=CAB66739.1; Type=Erroneous initiation; Note=Translation N-terminally extended;1 PDB 3D structure from :2DMI (3D) Secondary accessions : Q9H0G6 Q9P254Explore the universe of human proteins at neXtProt for TSHZ3: NX_Q63HK5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q63HK5 TSHZ3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_065907.2 ENSEMBL proteins: ENSP00000240587 Human Recombinant Protein Products for TSHZ3: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing TSHZ3 Antibody Products: Assay Products for TSHZ3:
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Protein
Domains /for TSHZ3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q63HK5 ProtoNet protein and cluster: Q63HK5
UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5 Similarity : Belongs to the teashirt C2H2-type zinc-finger protein familySimilarity : Contains 5 C2H2-type zinc fingersSimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor TSHZ3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TSH3_HUMAN, Q63HK5 Function : Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET andHDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tshz3) :About GeneDecksing Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSHZ3 (NM_020856 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSHZ3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSHZ3
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ3
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Pathways & Interactionsfor TSHZ3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSHZ3 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TSHZ3 (Q63HK5 3 ENSP00000240587 4 via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001656 metanephros development
IEA -- GO:0001657 ureteric bud development
IEA -- GO:0001701 in utero embryonic development
IEA -- GO:0002087 regulation of respiratory gaseous exchange by neurological system process
ISS -- GO:0006351 transcription, DNA-dependent
IEA --
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Drugs & Compoundsfor TSHZ3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TSHZ3 TSHZ3 / TSH3
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Transcriptsfor TSHZ3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TSHZ3 gene: NM_020856.2 Unigene Cluster for TSHZ3:
Teashirt zinc finger homeobox 3 Hs.278436 [show with all ESTs ] Unigene Representative Sequence: NM_020856 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000240587 (uc002nsy.4 ) ENST00000560707 ENST00000558569 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSHZ3 (NM_020856 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSHZ3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSHZ3
Additional cDNA sequence: AB040907.1 AK291466.1 AK293267.1 AL136805.1 BC127095.1 BC127096.1 BX648745.1
3 DOTS entries : DT.310254 DT.75114252
DT.121463523 24/101 AceView cDNA sequences (see all 101 ):
AL136805 D80947 AI582568 N70608 BX648745 BQ100745 BP378244 AI151043 AI540495 BG826712 BM722326 AL535086 CK823073 CR626691 W04928 AW183880 AI151039 CA447401 D80963 CA392895 AB040907 NM_020856 C14727 BQ884089 GeneLoc Exon Structure
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Expression for TSHZ3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TSHZ3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image TSHZ3 expression in embryonic tissues and stem cells About this table
See TSHZ3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSHZ3 SOURCE GeneReport for Unigene cluster: Hs.278436 UniProtKB/Swiss-Prot: TSH3_HUMAN, Q63HK5 Tissue specificity : Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer diseaseSABiosciences Custom PCR Arrays for TSHZ3 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ3
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Orthologsfor TSHZ3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for TSHZ3 gene from 5/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for TSHZ3 (if available)TreeFam Gene Tree for TSHZ3 (if available)
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Paralogsfor TSHZ3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TSHZ3 gene TSHZ1 2 TSHZ2 2 2 SIMAP similar genes for TSHZ3 using alignment to 2 protein entries: TSH3_HUMAN (see all proteins ):TSHZ1 TSHZ2 About GeneDecksing
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Genomic Variantsfor TSHZ3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for TSHZ3 (31765851 - 31840453 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TSHZ3 1 Indel 73349
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor TSHZ3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 614119
OMIM disorders : --3 : About MalaCards hydronephrosis alzheimer's disease neuronitis 1 disease from the University of Copenhagen DISEASES database for TSHZ3 :Hydronephrosis Human Genome Epidemiology (HuGE) Navigator: TSHZ3 (2 documents) Export disorders for TSHZ3 gene to outside databases
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Publicationsfor TSHZ3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TSHZ3 gene, integrated from 9 sources (see all 20 ):(articles sorted by number of sources associating them with TSHZ3) Utopia : connect your pdf to the dynamic
Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi -ureteric junction obstruction. (PubMed id 19745106) 1 , 2 (2010) FE65 binds Teashirt, inhibiting expression of the pri mate-specific caspase-4. (PubMed id 19343227) 1 , 2 (2009) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 (2001) Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331) 1 , 2 (2000) Teashirt-3, a novel regulator of muscle differentiati on, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression. (PubMed id 21543328) 1 (2011) Genetic loci associated with plasma phospholipid n-3 f atty acids: a meta-analysis of genome-wide association studies from the CHARGE C onsortium. (PubMed id 21829377) 1 (2011) Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and p rostate cancers. (PubMed id 21423795) 1 (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 (2011) Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624) 1 (2010) A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545) 1 (2009)
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External Searches for TSHZ3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TSHZ3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TSHZ3 gene
(According to HUGE )
About This Section
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Specialized Databases showing TSHZ3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for TSHZ3 Pharmacogenomics, SNPs, Pathways Protein Spotlight http://web.expasy.org/spotlight/back_issues/sptlt122.shtml
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About This Section Patent Information for TSHZ3 gene: TSHZ3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TSHZ3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TSHZ3 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TSHZ3 OriGene 3'-UTR Clone for TSHZ3 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TSHZ3 OriGene Custom Protein Services for TSHZ3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSHZ3 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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TSHZ3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ3
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSHZ3
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
