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Aliases for TSHZ3 Gene

Aliases for TSHZ3 Gene

  • Teashirt Zinc Finger Homeobox 3 2 3 5
  • Zinc Finger Protein 537 2 3 4
  • Teashirt Family Zinc Finger 3 2 3
  • ZNF537 3 4
  • TSH3 3 4
  • Teashirt Homolog 3 3
  • Teashirt 3 2
  • KIAA1474 4

External Ids for TSHZ3 Gene

Previous HGNC Symbols for TSHZ3 Gene

  • ZNF537

Previous GeneCards Identifiers for TSHZ3 Gene

  • GC19M036458
  • GC19M031765
  • GC19M028269

Summaries for TSHZ3 Gene

Entrez Gene Summary for TSHZ3 Gene

  • This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]

GeneCards Summary for TSHZ3 Gene

TSHZ3 (Teashirt Zinc Finger Homeobox 3) is a Protein Coding gene. Diseases associated with TSHZ3 include Hydronephrosis and Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TSHZ1.

UniProtKB/Swiss-Prot for TSHZ3 Gene

  • Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.

Gene Wiki entry for TSHZ3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSHZ3 Gene

Genomics for TSHZ3 Gene

Regulatory Elements for TSHZ3 Gene

Enhancers for TSHZ3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F031347 0.7 ENCODE 6.3 -0.8 -782 5.5 PKNOX1 ZNF2 GLIS2 KLF7 ZMIZ1 ZNF202 ZNF263 SP3 REST ZNF623 LOC105372360 THEG5 ENSG00000267012 LINC01533 ENSG00000267489 TSHZ3 ENSG00000278875
GH19F031328 1.3 Ensembl ENCODE 5.9 +17.4 17395 6.7 ZFP64 ZNF493 ZNF133 FEZF1 ZNF2 ZNF121 GLIS2 ZNF302 KLF7 ZNF548 TSHZ3 GC19M031336 GC19M031249
GH19F031408 0.9 Ensembl ENCODE 5.1 -59.3 -59316 1.6 JUND ATF3 HLF FOS TRIM28 RFX5 TSHZ3 ENSG00000267636 GC19M031384
GH19F031377 0.9 Ensembl ENCODE 4.7 -28.8 -28758 1.9 ZNF792 INSM2 SIN3A FEZF1 RAD21 GATA3 POLR2A ZNF600 FOS FOSL2 TSHZ3 GC19M031374 GC19P031388
GH19F031416 0.6 ENCODE 4.7 -69.6 -69602 4.4 MAX DPF2 GATA3 JUND BCL11A POLR2A POU5F1 CTBP2 KDM1A FOS TSHZ3 ENSG00000267636 GC19M031384
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TSHZ3 on UCSC Golden Path with GeneCards custom track

Promoters for TSHZ3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000345474 -453 4001 PKNOX1 ZNF2 GLIS2 KLF7 ZMIZ1 ZNF202 ZNF263 SP3 REST ZNF623

Genomic Location for TSHZ3 Gene

Chromosome:
19
Start:
31,274,945 bp from pter
End:
31,349,547 bp from pter
Size:
74,603 bases
Orientation:
Minus strand

Genomic View for TSHZ3 Gene

Genes around TSHZ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSHZ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSHZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSHZ3 Gene

Proteins for TSHZ3 Gene

  • Protein details for TSHZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HK5-TSH3_HUMAN
    Recommended name:
    Teashirt homolog 3
    Protein Accession:
    Q63HK5
    Secondary Accessions:
    • Q9H0G6
    • Q9P254

    Protein attributes for TSHZ3 Gene

    Size:
    1081 amino acids
    Molecular mass:
    118566 Da
    Quaternary structure:
    • Interacts (via homeobox domain) with APBB1 (via PID domain 1). Interacts (via N-terminus) with HDAC1 and HDAC2; the interaction is direct. Found in a trimeric complex with APBB1 and HDAC1; the interaction between HDAC1 and APBB1 is mediated by TSHZ3.
    SequenceCaution:
    • Sequence=CAB66739.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TSHZ3 Gene

neXtProt entry for TSHZ3 Gene

Post-translational modifications for TSHZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSHZ3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSHZ3 Gene

Domains & Families for TSHZ3 Gene

Protein Domains for TSHZ3 Gene

Suggested Antigen Peptide Sequences for TSHZ3 Gene

Graphical View of Domain Structure for InterPro Entry

Q63HK5

UniProtKB/Swiss-Prot:

TSH3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the teashirt C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the teashirt C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with TSHZ3: view

Function for TSHZ3 Gene

Molecular function for TSHZ3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.

Gene Ontology (GO) - Molecular Function for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 19343227
GO:0005515 protein binding IPI 19343227
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TSHZ3: view
genes like me logo Genes that share phenotypes with TSHZ3: view

Animal Models for TSHZ3 Gene

MGI Knock Outs for TSHZ3:

Animal Model Products

miRNA for TSHZ3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSHZ3 Gene

Localization for TSHZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSHZ3 Gene

Nucleus. Cell projection, growth cone. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSHZ3 Gene COMPARTMENTS Subcellular localization image for TSHZ3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19343227
GO:0005654 nucleoplasm IDA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TSHZ3: view

Pathways & Interactions for TSHZ3 Gene

SuperPathways for TSHZ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSHZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with TSHZ3: view

No data available for Pathways by source and SIGNOR curated interactions for TSHZ3 Gene

Transcripts for TSHZ3 Gene

mRNA/cDNA for TSHZ3 Gene

Unigene Clusters for TSHZ3 Gene

Teashirt zinc finger homeobox 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSHZ3 Gene

No ASD Table

Relevant External Links for TSHZ3 Gene

GeneLoc Exon Structure for
TSHZ3
ECgene alternative splicing isoforms for
TSHZ3

Expression for TSHZ3 Gene

mRNA expression in normal human tissues for TSHZ3 Gene

mRNA differential expression in normal tissues according to GTEx for TSHZ3 Gene

This gene is overexpressed in Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for TSHZ3 Gene

This gene is overexpressed in Liver, secretome (46.5) and Cardia (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSHZ3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSHZ3 Gene:

TSHZ3

SOURCE GeneReport for Unigene cluster for TSHZ3 Gene:

Hs.278436

mRNA Expression by UniProt/SwissProt for TSHZ3 Gene:

Q63HK5-TSH3_HUMAN
Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
genes like me logo Genes that share expression patterns with TSHZ3: view

Primer Products

No data available for Protein tissue co-expression partners for TSHZ3 Gene

Orthologs for TSHZ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSHZ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSHZ3 34 35
  • 99.33 (n)
oppossum
(Monodelphis domestica)
Mammalia TSHZ3 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSHZ3 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSHZ3 34 35
  • 90.44 (n)
dog
(Canis familiaris)
Mammalia TSHZ3 34 35
  • 89.64 (n)
rat
(Rattus norvegicus)
Mammalia Tshz3 34
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia Tshz3 34 16 35
  • 88.5 (n)
chicken
(Gallus gallus)
Aves TSHZ3 34 35
  • 79.3 (n)
lizard
(Anolis carolinensis)
Reptilia TSHZ3 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tshz3 34
  • 75.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9022 34
zebrafish
(Danio rerio)
Actinopterygii TSHZ3 (1 of 2) 35
  • 72 (a)
OneToMany
tshz3b 34
  • 71.05 (n)
TSHZ3 (2 of 2) 35
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5824 35
  • 17 (a)
OneToMany
Species where no ortholog for TSHZ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSHZ3 Gene

ENSEMBL:
Gene Tree for TSHZ3 (if available)
TreeFam:
Gene Tree for TSHZ3 (if available)

Paralogs for TSHZ3 Gene

Paralogs for TSHZ3 Gene

(2) SIMAP similar genes for TSHZ3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSHZ3: view

Variants for TSHZ3 Gene

Sequence variations from dbSNP and Humsavar for TSHZ3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs193921027 Uncertain significance 31,278,612(-) GAGCT(C/T)GCATG intron-variant, reference, missense
rs1003244 -- 31,255,500(-) CTCTT(A/G)GTGGT intron-variant
rs1013523 -- 31,255,130(+) GAAAA(C/T)GAAGG intron-variant
rs10164349 -- 31,151,134(+) TTTGA(C/T)GAAGA nc-transcript-variant
rs1027452 -- 31,230,018(-) taaat(G/T)aacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSHZ3 Gene

Variant ID Type Subtype PubMed ID
esv25402 CNV loss 19812545
esv2718454 CNV deletion 23290073
nsv472228 CNV novel sequence insertion 20440878
nsv510764 CNV deletion 20534489
nsv828522 CNV gain 20364138

Variation tolerance for TSHZ3 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSHZ3 Gene

Human Gene Mutation Database (HGMD)
TSHZ3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSHZ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSHZ3 Gene

Disorders for TSHZ3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSHZ3 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TSHZ3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSHZ3

Genetic Association Database (GAD)
TSHZ3
Human Genome Epidemiology (HuGE) Navigator
TSHZ3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSHZ3
genes like me logo Genes that share disorders with TSHZ3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSHZ3 Gene

Publications for TSHZ3 Gene

  1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. (PMID: 19745106) Jenkins D. … Woolf A.S. (Nephrol. Dial. Transplant. 2010) 3 4 46 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. (PMID: 19343227) Kajiwara Y. … Buxbaum J.D. (PLoS ONE 2009) 3 4 64
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for TSHZ3 Gene

Sources for TSHZ3 Gene

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