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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSHZ2 Gene

protein-coding   GIFtS: 48
GCID: GC20P051588

teashirt zinc finger homeobox 2

(Previous names: chromosome 20 open reading frame 17, zinc finger protein...)
(Previous symbols: C20orf17, ZNF218)
 Explore 5 diseases affiliated with
TSHZ2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TSHZ2    

Aliases
for TSHZ2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Teashirt Zinc Finger Homeobox 21 2     Teashirt Family Zinc Finger 21 2
Zinc Finger Protein 2181 2 3     Ovarian Cancer-Related Protein 10-22 3
C20orf171 2 3     Chromosome 20 Open Reading Frame 171
OVC10-21 2 3     Cell Growth-Inhibiting Protein 72
TSH21 2 3     Serologically Defined Colon Cancer Antigen 33 Like2
ZNF2181 2 3     Teashirt Homolog 22
ZABC21 2     

External Ids:    HGNC: 130101   Entrez Gene: 1285532   Ensembl: ENSG000001824637   OMIM: 6141185   UniProtKB: Q9NRE23   

Export aliases for TSHZ2 gene to outside databases

Previous GC identifers: GC20P051024 GC20P048335


Summaries
for TSHZ2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2
Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional
repressor (Potential)




Genomic Views
for TSHZ2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSHZ2 gene promoter:
         RP58   CUTL1   Evi-1   POU2F1   POU2F1a   FOXO1a   IRF-7A   aMEF-2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSHZ2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSHZ2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSHZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.2

TSHZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHZ2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P051588:  view genomic region     (about GC identifiers)

Start:
 51,588,946 bp from pter      End:
 52,111,869 bp from pter
Size:
 522,924 bases      Orientation:
 plus strand

Proteins
for TSHZ2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2 (See protein sequence)
Recommended Name: Teashirt homolog 2  
Size: 1034 amino acids; 115005 Da
Subunit: Interacts (via homeobox domain) with APBB1 (via PID domain 1) (By similarity)
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAF76850.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due
translation of a 3'-UTR region;
Secondary accessions: B7Z7W1 J3KNQ0 Q4VXM4 Q6N003 Q8N260
Alternative splicing: 2 isoforms:  Q9NRE2-1   Q9NRE2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSHZ2: NX_Q9NRE2

Post-translational modifications:

  • Sumoylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRE2

    • TSHZ2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180350.1  NP_775756.3  

    ENSEMBL proteins: 
     ENSP00000360552   ENSP00000333114  

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    Uscn Proteins for TSHZ2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TSHZ2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TSHZ2

    Protein Domains /
    Families
    for TSHZ2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TSHZ2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR015880 Znf_C2H2-like
     IPR027008 Teashirt_fam
     IPR001356 Homeodomain
     IPR027010 Tshz2
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9NRE2

    ProtoNet protein and cluster: Q9NRE2

    UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2
    Similarity: Belongs to the teashirt C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for TSHZ2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2
    Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional
    repressor (Potential)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSHZ2
    8/261 QIAGEN miScript miRNA Assays for microRNAs that regulate TSHZ2 (see all 261):
    hsa-miR-124* hsa-miR-579 hsa-miR-605 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TSHZ2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    TSHZ2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TSHZ2:
     Decreased viability with pacli 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tshz2):
     embryogenesis  mortality/aging 

    TSHZ2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TSHZ2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSHZ2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TSHZ2 (Q9NRE23 ENSP000003331144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002133, ENSP000002994024I2D: score=1 STRING: ENSP00000299402
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--


    TSHZ2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TSHZ2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSHZ2
    Search CenterWatch for drugs/clinical trials and news about TSHZ2 / TSH2 

    Transcripts
    for TSHZ2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSHZ2 gene (2 alternative transcripts): 
    NM_001193421.1  NM_173485.5  

    Unigene Cluster for TSHZ2:

    Teashirt zinc finger homeobox 2
    Hs.473117  [show with all ESTs]
    Unigene Representative Sequence: NM_173485
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371497(uc002xwo.3 uc021wex.1) ENST00000329613 ENST00000559286


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    8/261 QIAGEN miScript miRNA Assays for microRNAs that regulate TSHZ2 (see all 261):
    hsa-miR-124* hsa-miR-579 hsa-miR-605 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TSHZ2 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHZ2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHZ2
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    Additional cDNA sequence: 

    AF230201.1 AK091206.1 AK302570.1 AY926481.1 BX640770.1 BX648148.1 

    11 DOTS entries:

    DT.310441  DT.97826977  DT.95283019  DT.91703994  DT.91885144  DT.40232696  DT.70103887  DT.40111230 
    DT.422804  DT.426156  DT.95131589 

    24/84 AceView cDNA sequences (see all 84):

    AA954959 BP873579 AK091206 AW511820 BQ710521 BE219085 AI129629 BE467466 
    AX746848 AA406466 CK826257 BM672622 AI468573 BQ708541 BQ548689 AI302759 
    BM968738 CA405462 BX103895 BE154480 AI703266 AI279021 BE326344 AL732164 

    GeneLoc Exon Structure


    Expression
    for TSHZ2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSHZ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAATTGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TSHZ2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

    See TSHZ2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSHZ2

    SOURCE GeneReport for Unigene cluster: Hs.473117

    UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2
    Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease

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    In Situ
    Assay Products:     
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    Orthologs
    for TSHZ2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TSHZ2 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TSHZ21 teashirt zinc finger homeobox 2 78.42(n)
    84.4(a)    		   419341  XM_417506.3  XP_417506.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TSHZ26
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343226.1(464488-467553)
    zebrafish
    (Danio rerio)    		 Actinopterygii tshz21 teashirt zinc finger homeobox 2 62.83(n)
    60.95(a)    		   100332862  XM_002666523.2  XP_002666569.2 


    ENSEMBL Gene Tree for TSHZ2 (if available)
    TreeFam Gene Tree for TSHZ2 (if available) 

    Paralogs
    for TSHZ2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSHZ2 gene
    TSHZ32  TSHZ12  
    6 SIMAP similar genes for TSHZ2 using alignment to 2 protein entries:     TSH2_HUMAN (see all proteins):
    ADAMTS8    ADAMTS1    ADAMTS15    DKFZp686E01144    TSHZ1    TSHZ3

    TSHZ2 for paralogs           About GeneDecksing



    Genomic Variants
    for TSHZ2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9960 NCBI SNPs in TSHZ2 are shown (see all 9960)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1439318961,2
    		--51586995(+) GCAGGC/TGTATA 1 -- us2k10--------
    rs354584141,2
    		C,--51587063(+) ATTGTA/GTAAAG 1 -- us2k14Minor allele frequency- G:0.15NA WA EA 360
    rs1378953361,2
    		C,--51587077(+) TGTGG-/TATA  
                TATAT     		1 -- us2k10--------
    rs571394291,2
    		C,--51587111(+) TATATA/GTATGT 1 -- us2k14Minor allele frequency- G:0.14WA NA EA 360
    rs1471838881,2
    		--51587113(+) TATATA/GTGTGT 1 -- us2k10--------
    rs759040721,2
    		F,--51587245(+) TAACTC/TAGGAT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1823933391,2
    		--51587246(+) AACTCA/GGGATC 1 -- us2k10--------
    rs1405317521,2
    		--51587265(+) AATACC/TACACG 1 -- us2k10--------
    rs732841311,2
    		C,--51587289(+) GTGGGA/GGCTAA 1 -- us2k12Minor allele frequency- G:0.08WA 120
    rs783589351,2
    		F,--51587295(+) GCTAAT/CGCATG 1 -- us2k11Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for TSHZ2 (51588946 - 51838946 bp, first 250kb of TSHZ2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TSHZ2
         2 CNVs: 102989 102988
         1 Indel: 40459

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    DNA2.0 Custom Variant and Variant Library Synthesis for TSHZ2

    Disorders / Diseases
    for TSHZ2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TSHZ2 for disorders           About GeneDecksing

    OMIM gene information: 614118    OMIM disorders: --

    5 diseases for TSHZ2:    About MalaCards
    ovarian cancer    colon cancer    alzheimer's disease    breast carcinoma
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: TSHZ2 (5 documents)

    Export disorders for TSHZ2 gene to outside databases

    Publications
    for TSHZ2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSHZ2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TSHZ2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi -ureteric junction obstruction. (PubMed id 19745106)1, 2 Jenkins D....Woolf A.S. (2010)
    2. FE65 binds Teashirt, inhibiting expression of the pri mate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y....Buxbaum J.D. (2009)
    3. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PubMed id 9671742)1, 3 Collins C.... Gray J.W. (1998)
    7. Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and p rostate cancers. (PubMed id 21423795)1 Yamamoto M....Yamamoto F. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    External Searches for TSHZ2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TSHZ2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 128553 HGNC: 13010 AceView: C20orf17 Ensembl:ENSG00000182463 euGenes: HUgn128553
    ECgene: TSHZ2 H-InvDB: TSHZ2

    Other Databases showing TSHZ2 gene

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    Specialized Databases showing TSHZ2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for TSHZ2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    		Patent Information for TSHZ2 gene:
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