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Aliases for TSHZ2 Gene

Aliases for TSHZ2 Gene

  • Teashirt Zinc Finger Homeobox 2 2 3 5
  • Zinc Finger Protein 218 2 3 4
  • Ovarian Cancer-Related Protein 10-2 3 4
  • Teashirt Family Zinc Finger 2 2 3
  • C20orf17 3 4
  • OVC10-2 3 4
  • ZNF218 3 4
  • TSH2 3 4
  • Serologically Defined Colon Cancer Antigen 33 Like 3
  • Chromosome 20 Open Reading Frame 17 2
  • Cell Growth-Inhibiting Protein 7 3
  • ZABC2 3

External Ids for TSHZ2 Gene

Previous HGNC Symbols for TSHZ2 Gene

  • C20orf17
  • ZNF218

Previous GeneCards Identifiers for TSHZ2 Gene

  • GC20P051024
  • GC20P051588
  • GC20P048335

Summaries for TSHZ2 Gene

GeneCards Summary for TSHZ2 Gene

TSHZ2 (Teashirt Zinc Finger Homeobox 2) is a Protein Coding gene. An important paralog of this gene is TSHZ1.

UniProtKB/Swiss-Prot for TSHZ2 Gene

  • Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSHZ2 Gene

Genomics for TSHZ2 Gene

Regulatory Elements for TSHZ2 Gene

Promoters for TSHZ2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSHZ2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSHZ2 Gene

52,972,309 bp from pter
53,495,330 bp from pter
523,022 bases
Plus strand

Genomic View for TSHZ2 Gene

Genes around TSHZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSHZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSHZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSHZ2 Gene

Proteins for TSHZ2 Gene

  • Protein details for TSHZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Teashirt homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7Z7W1
    • J3KNQ0
    • Q4VXM4
    • Q6N003
    • Q8N260

    Protein attributes for TSHZ2 Gene

    1034 amino acids
    Molecular mass:
    115005 Da
    Quaternary structure:
    • Interacts (via homeobox domain) with APBB1 (via PID domain 1).
    • Sequence=AAF76850.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due translation of a 3-UTR region.; Evidence={ECO:0000305};

    Alternative splice isoforms for TSHZ2 Gene


neXtProt entry for TSHZ2 Gene

Proteomics data for TSHZ2 Gene at MOPED

Post-translational modifications for TSHZ2 Gene

Other Protein References for TSHZ2 Gene

Antibody Products

No data available for DME Specific Peptides for TSHZ2 Gene

Domains & Families for TSHZ2 Gene

Protein Domains for TSHZ2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the teashirt C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the teashirt C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with TSHZ2: view

Function for TSHZ2 Gene

Molecular function for TSHZ2 Gene

UniProtKB/Swiss-Prot Function:
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).
genes like me logo Genes that share phenotypes with TSHZ2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSHZ2 Gene

Localization for TSHZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSHZ2 Gene

Subcellular locations from

Jensen Localization Image for TSHZ2 Gene COMPARTMENTS Subcellular localization image for TSHZ2 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TSHZ2 Gene

Pathways & Interactions for TSHZ2 Gene

SuperPathways for TSHZ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSHZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with TSHZ2: view

No data available for Pathways by source and SIGNOR curated interactions for TSHZ2 Gene

Drugs & Compounds for TSHZ2 Gene

No Compound Related Data Available

Transcripts for TSHZ2 Gene

Unigene Clusters for TSHZ2 Gene

Teashirt zinc finger homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSHZ2 Gene

No ASD Table

Relevant External Links for TSHZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSHZ2 Gene

mRNA expression in normal human tissues for TSHZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSHZ2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for TSHZ2 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSHZ2 Gene

SOURCE GeneReport for Unigene cluster for TSHZ2 Gene Hs.473117

mRNA Expression by UniProt/SwissProt for TSHZ2 Gene

Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
genes like me logo Genes that share expression patterns with TSHZ2: view

Protein tissue co-expression partners for TSHZ2 Gene

Primer Products

In Situ Assay Products

Orthologs for TSHZ2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSHZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSHZ2 35
  • 87.4 (n)
  • 92.84 (a)
TSHZ2 36
  • 92 (a)
(Canis familiaris)
Mammalia TSHZ2 35
  • 87.06 (n)
  • 90.61 (a)
TSHZ2 36
  • 89 (a)
(Mus musculus)
Mammalia Tshz2 35
  • 85.89 (n)
  • 90.47 (a)
Tshz2 16
Tshz2 36
  • 90 (a)
(Pan troglodytes)
Mammalia TSHZ2 35
  • 99.26 (n)
  • 99.52 (a)
TSHZ2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tshz2 35
  • 85.44 (n)
  • 89.69 (a)
(Monodelphis domestica)
Mammalia TSHZ2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TSHZ2 36
  • 86 (a)
(Gallus gallus)
Aves TSHZ2 35
  • 78.59 (n)
  • 84.5 (a)
TSHZ2 36
  • 83 (a)
(Anolis carolinensis)
Reptilia TSHZ2 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tshz2 35
  • 70.03 (n)
  • 72.57 (a)
(Danio rerio)
Actinopterygii tshz2 35
  • 63.95 (n)
  • 63.11 (a)
TSHZ2 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7523 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5824 36
  • 15 (a)
Species with no ortholog for TSHZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSHZ2 Gene

Gene Tree for TSHZ2 (if available)
Gene Tree for TSHZ2 (if available)

Paralogs for TSHZ2 Gene

Paralogs for TSHZ2 Gene

(6) SIMAP similar genes for TSHZ2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSHZ2: view

Variants for TSHZ2 Gene

Sequence variations from dbSNP and Humsavar for TSHZ2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs739869 - 53,253,797(+) GTCAG(C/G)CTTCC nc-transcript-variant, reference, missense
rs6097319 - 53,255,499(+) GGTGC(A/G)CCCTC nc-transcript-variant, reference, missense
rs2257 -- 53,195,915(-) TCTCC(C/G)TTTCT intron-variant
rs81489 -- 53,387,382(-) CCACA(C/T)AGAAT intron-variant
rs121646 -- 53,359,098(+) AAGTA(C/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSHZ2 Gene

Variant ID Type Subtype PubMed ID
nsv459006 CNV Loss 19166990
nsv834005 CNV Gain 17160897
nsv526701 CNV Loss 19592680
nsv912934 CNV Gain 21882294
nsv523160 CNV Loss 19592680
esv269587 CNV Insertion 20981092
esv2656881 CNV Deletion 23128226
esv2722529 CNV Deletion 23290073
esv2722530 CNV Deletion 23290073
nsv828743 CNV Gain 20364138
esv2677315 CNV Deletion 23128226
nsv519558 CNV Loss 19592680
nsv459007 CNV Gain 19166990
esv2616689 CNV Insertion 19546169
esv1006643 CNV Insertion 20482838
esv1298126 CNV Insertion 17803354
esv2557335 CNV Deletion 19546169
dgv794e199 CNV Deletion 23128226
esv2722531 CNV Deletion 23290073
esv2669822 CNV Deletion 23128226
esv2722532 CNV Deletion 23290073

Variation tolerance for TSHZ2 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSHZ2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSHZ2 Gene

Disorders for TSHZ2 Gene

Relevant External Links for TSHZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSHZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSHZ2 Gene

Publications for TSHZ2 Gene

  1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. (PMID: 19745106) Jenkins D. … Woolf A.S. (Nephrol. Dial. Transplant. 2010) 3 4 48 67
  2. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PMID: 9671742) Collins C. … Gray J.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. Promyelocytic Leukemia protein (PML) interacts with ASC to limit Inflammasome Activation. (PMID: 24407287) Dowling J.K. … O'Neill L.A. (J. Biol. Chem. 2014) 3
  4. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. (PMID: 24322204) Winham S.J. … Biernacka J.M. (Mol. Psychiatry 2013) 3
  5. Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers. (PMID: 21423795) Yamamoto M. … Yamamoto F. (PLoS ONE 2011) 3

Products for TSHZ2 Gene

Sources for TSHZ2 Gene

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