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Aliases for TSHZ2 Gene

Aliases for TSHZ2 Gene

  • Teashirt Zinc Finger Homeobox 2 2 3
  • Zinc Finger Protein 218 2 3 4
  • Ovarian Cancer-Related Protein 10-2 3 4
  • Teashirt Family Zinc Finger 2 2 3
  • C20orf17 3 4
  • OVC10-2 3 4
  • ZNF218 3 4
  • TSH2 3 4
  • Serologically Defined Colon Cancer Antigen 33 Like 3
  • Chromosome 20 Open Reading Frame 17 2
  • Cell Growth-Inhibiting Protein 7 3
  • Teashirt Homolog 2 3
  • ZABC2 3

External Ids for TSHZ2 Gene

Previous Symbols for TSHZ2 Gene

  • C20orf17
  • ZNF218

Summaries for TSHZ2 Gene

GeneCards Summary for TSHZ2 Gene

TSHZ2 (Teashirt Zinc Finger Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is TSHZ1.

UniProtKB/Swiss-Prot for TSHZ2 Gene

  • Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSHZ2 Gene

Genomics for TSHZ2 Gene

Genomic Location for TSHZ2 Gene

52,972,407 bp from pter
53,495,330 bp from pter
522,924 bases
Plus strand

Genomic View for TSHZ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSHZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSHZ2 Gene

Regulatory Elements for TSHZ2 Gene

Proteins for TSHZ2 Gene

  • Protein details for TSHZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Teashirt homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7Z7W1
    • J3KNQ0
    • Q4VXM4
    • Q6N003
    • Q8N260

    Protein attributes for TSHZ2 Gene

    1034 amino acids
    Molecular mass:
    115005 Da
    Quaternary structure:
    • Interacts (via homeobox domain) with APBB1 (via PID domain 1).
    • Sequence=AAF76850.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due translation of a 3-UTR region.; Evidence={ECO:0000305};

    Alternative splice isoforms for TSHZ2 Gene


neXtProt entry for TSHZ2 Gene

Proteomics data for TSHZ2 Gene at MOPED

Post-translational modifications for TSHZ2 Gene

Other Protein References for TSHZ2 Gene

No data available for DME Specific Peptides for TSHZ2 Gene

Domains for TSHZ2 Gene

Gene Families for TSHZ2 Gene

  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class
  • TSHZ :Teashirt zinc fingers

Protein Domains for TSHZ2 Gene


  • Contains 1 homeobox DNA-binding domain.:
    • Q9NRE2
  • Belongs to the teashirt C2H2-type zinc-finger protein family.:
    • Q9NRE2
  • Contains 5 C2H2-type zinc fingers.:
    • Q9NRE2
genes like me logo Genes that share domains with TSHZ2: view

Function for TSHZ2 Gene

Molecular function for TSHZ2 Gene

UniProtKB/Swiss-Prot Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).

Gene Ontology (GO) - Molecular Function for TSHZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 24407287
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TSHZ2: view

Phenotypes for TSHZ2 Gene

MGI mutant phenotypes for TSHZ2:
inferred from 1 alleles
GenomeRNAi human phenotypes for TSHZ2:
genes like me logo Genes that share phenotypes with TSHZ2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSHZ2 Gene

Localization for TSHZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSHZ2 Gene

Subcellular locations from

Jensen Localization Image for TSHZ2 Gene COMPARTMENTS Subcellular localization image for TSHZ2 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TSHZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TSHZ2: view

Pathways for TSHZ2 Gene

SuperPathways for TSHZ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSHZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0010468 regulation of gene expression --
genes like me logo Genes that share ontologies with TSHZ2: view

No data available for Pathways by source for TSHZ2 Gene

Transcripts for TSHZ2 Gene

Unigene Clusters for TSHZ2 Gene

Teashirt zinc finger homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSHZ2 Gene

No ASD Table

Relevant External Links for TSHZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSHZ2 Gene

mRNA expression in normal human tissues for TSHZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSHZ2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSHZ2 Gene

SOURCE GeneReport for Unigene cluster for TSHZ2 Gene Hs.473117

mRNA Expression by UniProt/SwissProt for TSHZ2 Gene

Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
genes like me logo Genes that share expressions with TSHZ2: view

Orthologs for TSHZ2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSHZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSHZ2 36
  • 99.26 (n)
  • 99.52 (a)
TSHZ2 37
  • 100 (a)
(Bos Taurus)
Mammalia TSHZ2 36
  • 87.4 (n)
  • 92.84 (a)
TSHZ2 37
  • 92 (a)
(Canis familiaris)
Mammalia TSHZ2 36
  • 87.06 (n)
  • 90.61 (a)
TSHZ2 37
  • 89 (a)
(Mus musculus)
Mammalia Tshz2 36
  • 85.89 (n)
  • 90.47 (a)
Tshz2 16
Tshz2 37
  • 90 (a)
(Monodelphis domestica)
Mammalia TSHZ2 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TSHZ2 37
  • 86 (a)
(Rattus norvegicus)
Mammalia Tshz2 36
  • 85.44 (n)
  • 89.69 (a)
(Gallus gallus)
Aves TSHZ2 36
  • 78.59 (n)
  • 84.5 (a)
TSHZ2 37
  • 83 (a)
(Anolis carolinensis)
Reptilia TSHZ2 37
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tshz2 36
  • 70.03 (n)
  • 72.57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7523 36
(Danio rerio)
Actinopterygii tshz2 36
  • 63.95 (n)
  • 63.11 (a)
TSHZ2 37
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5824 37
  • 15 (a)
Species with no ortholog for TSHZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSHZ2 Gene

Gene Tree for TSHZ2 (if available)
Gene Tree for TSHZ2 (if available)

Paralogs for TSHZ2 Gene

Paralogs for TSHZ2 Gene

Selected SIMAP similar genes for TSHZ2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSHZ2: view

Variants for TSHZ2 Gene

Sequence variations from dbSNP and Humsavar for TSHZ2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1512 -- 53,443,019(+) GAACA(C/T)TGAGT intron-variant
rs2257 -- 53,195,915(-) TCTCC(C/G)TTTCT intron-variant
rs81489 -- 53,387,382(-) CCACA(C/T)AGAAT intron-variant
rs121646 -- 53,359,098(+) AAGTA(C/T)TATTT intron-variant
rs149339 -- 53,395,056(+) AGGTA(A/G)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSHZ2 Gene

Variant ID Type Subtype PubMed ID
nsv459006 CNV Loss 19166990
nsv834005 CNV Gain 17160897
nsv526701 CNV Loss 19592680
nsv912934 CNV Gain 21882294
nsv523160 CNV Loss 19592680
esv269587 CNV Insertion 20981092
esv2656881 CNV Deletion 23128226
esv2722529 CNV Deletion 23290073
esv2722530 CNV Deletion 23290073
nsv828743 CNV Gain 20364138
esv2677315 CNV Deletion 23128226
nsv519558 CNV Loss 19592680
nsv459007 CNV Gain 19166990
esv2616689 CNV Insertion 19546169
esv1006643 CNV Insertion 20482838
esv1298126 CNV Insertion 17803354
esv2557335 CNV Deletion 19546169
dgv794e199 CNV Deletion 23128226
esv2722531 CNV Deletion 23290073
esv2669822 CNV Deletion 23128226
esv2722532 CNV Deletion 23290073

Relevant External Links for TSHZ2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TSHZ2 Gene

Relevant External Links for TSHZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TSHZ2: view

No data available for UniProtKB/Swiss-Prot for TSHZ2 Gene

Publications for TSHZ2 Gene

  1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. (PMID: 19745106) Jenkins D. … Woolf A.S. (Nephrol. Dial. Transplant. 2010) 3 4 49
  2. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PMID: 15561718) Gocke C.B. … Kang J. (J. Biol. Chem. 2005) 3 4
  5. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PMID: 9671742) Collins C. … Gray J.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3

Products for TSHZ2 Gene

Sources for TSHZ2 Gene

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