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TSHZ2 Gene

protein-coding   GIFtS: 50
GCID: GC20P051588

Teashirt Zinc Finger Homeobox 2

(Previous names: chromosome 20 open reading frame 17, zinc finger protein...)
(Previous symbols: C20orf17, ZNF218)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Teashirt Zinc Finger Homeobox 21 2     TSH22 3
Zinc Finger Protein 2181 2 3     Chromosome 20 Open Reading Frame 171
C20orf171 2 3     ZABC22
ZNF2181 2 3     Cell Growth-Inhibiting Protein 72
Teashirt Family Zinc Finger 21 2     Serologically Defined Colon Cancer Antigen 33 Like2
Ovarian Cancer-Related Protein 10-22 3     Teashirt Homolog 22
OVC10-22 3     

External Ids:    HGNC: 130101   Entrez Gene: 1285532   Ensembl: ENSG000001824637   OMIM: 6141185   UniProtKB: Q9NRE23   

Export aliases for TSHZ2 gene to outside databases

Previous GC identifers: GC20P051024 GC20P048335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSHZ2 Gene:
TSHZ2 (teashirt zinc finger homeobox 2) is a protein-coding gene. Diseases associated with TSHZ2 include ovarian cancer, and alzheimer's disease. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TSHZ3.

UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2
Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional
repressor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSHZ2 gene promoter:
         RP58   CUTL1   Evi-1   POU2F1   POU2F1a   FOXO1a   IRF-7A   aMEF-2   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSHZ2 promoter sequence
   Search Chromatin IP Primers for TSHZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSHZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.2

TSHZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHZ2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P051588:  view genomic region     (about GC identifiers)

Start:
51,588,946 bp from pter      End:
52,111,869 bp from pter
Size:
522,924 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2 (See protein sequence)
Recommended Name: Teashirt homolog 2  
Size: 1034 amino acids; 115005 Da
Subunit: Interacts (via homeobox domain) with APBB1 (via PID domain 1) (By similarity)
Sequence caution: Sequence=AAF76850.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown
due translation of a 3'-UTR region;
Secondary accessions: B7Z7W1 J3KNQ0 Q4VXM4 Q6N003 Q8N260
Alternative splicing: 2 isoforms:  Q9NRE2-1   Q9NRE2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSHZ2: NX_Q9NRE2

Explore proteomics data for TSHZ2 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSHZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180350.1  NP_775756.3  

    ENSEMBL proteins: 
     ENSP00000360552   ENSP00000475114   ENSP00000474159   ENSP00000333114  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class
    TSHZ: Teashirt zinc fingers
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR027008 Teashirt_fam
     IPR015880 Znf_C2H2-like
     IPR001356 Homeobox_dom
     IPR027010 Tshz2
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NRE2

    ProtoNet protein and cluster: Q9NRE2

    UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2
    Similarity: Belongs to the teashirt C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    TSHZ2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSH2_HUMAN, Q9NRE2
    Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional
    repressor (Potential)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    TSHZ2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSHZ2:
     Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tshz2):
     embryogenesis  mortality/aging 

    TSHZ2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSHZ2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TSHZ2 (see all 261):
    hsa-miR-124* hsa-miR-579 hsa-miR-605 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidTSHZ2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TSHZ2

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    GenScript: all cDNA clones in your preferred vector (see all 2): TSHZ2 (NM_173485)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSH2_HUMAN, Q9NRE2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TSHZ2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSHZ2
    Interactions:

        Search GeneGlobe Interaction Network for TSHZ2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TSHZ2 (Q9NRE23 ENSP000003331144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002133, ENSP000002994024I2D: score=1 STRING: ENSP00000299402
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development IEA--
    GO:0010468regulation of gene expression ----

    TSHZ2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSHZ2 (TSH2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSHZ2 gene (2 alternative transcripts): 
    NM_001193421.1  NM_173485.5  

    Unigene Cluster for TSHZ2:

    Teashirt zinc finger homeobox 2
    Hs.473117  [show with all ESTs]
    Unigene Representative Sequence: NM_173485
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371497(uc002xwo.3 uc021wex.1) ENST00000603338 ENST00000605656
    ENST00000329613

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TSHZ2 (see all 261):
    hsa-miR-124* hsa-miR-579 hsa-miR-605 hsa-miR-3162-5p hsa-miR-1273d hsa-miR-520b hsa-miR-3690 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidTSHZ2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TSHZ2 (NM_173485)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHZ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHZ2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSHZ2
      QuantiTect SYBR Green Assays in human, mouse, rat TSHZ2
      QuantiFast Probe-based Assays in human, mouse, rat TSHZ2

    Additional mRNA sequence: 

    AF230201.1 AK091206.1 AK302570.1 AY926481.1 BX640770.1 BX648148.1 

    11 DOTS entries:

    DT.310441  DT.97826977  DT.95283019  DT.91703994  DT.91885144  DT.40232696  DT.70103887  DT.40111230 
    DT.422804  DT.426156  DT.95131589 

    Selected AceView cDNA sequences (see all 84):

    BQ710521 AK091206 AW511820 BE467466 BE219085 BP873579 AA406466 AA954959 
    AX746848 CK826257 AI129629 BM672622 AI694059 BM978368 AV728738 BE154504 
    AA361046 AI468573 BE326344 BE154479 BX640770 BX648148 CA405462 AI420506 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSHZ2 expression in normal human tissues (normalized intensities)      TSHZ2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATTGTTT
    TSHZ2 Expression
    About this image


    TSHZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Progress Zone Cells Limb Bud
             Autopod
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Bone (Muscoskeletal System)
             Progress Zone Cells Limb Bud
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    TSHZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSHZ2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473117

    UniProtKB/Swiss-Prot: TSH2_HUMAN, Q9NRE2
    Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TSHZ2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tshz21 , 5 teashirt zinc finger family member 21, 5 85.89(n)1
    90.47(a)1
      2 (89.47 cM)5
    2289111  NM_080455.21  NP_536703.21 
     1696330135 
    chicken
    (Gallus gallus)
    Aves TSHZ21 teashirt zinc finger homeobox 2 78.59(n)
    84.5(a)
      419341  XM_004947254.1  XP_004947311.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSHZ26
    teashirt zinc finger homeobox 2
    80(a)
    1 ↔ 1
    GL343226.1(464488-467553)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tshz21 teashirt zinc finger homeobox 2 70.03(n)
    72.57(a)
      100497744  XM_002935395.2  XP_002935441.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tshz21 teashirt zinc finger homeobox 2 63.95(n)
    63.11(a)
      100332862  XM_005174126.1  XP_005174183.1 


    ENSEMBL Gene Tree for TSHZ2 (if available)
    TreeFam Gene Tree for TSHZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSHZ2 gene
    TSHZ32  TSHZ12  
    6 SIMAP similar genes for TSHZ2 using alignment to 3 protein entries:     TSH2_HUMAN (see all proteins):
    ADAMTS8    ADAMTS1    ADAMTS15    DKFZp686E01144    TSHZ1    TSHZ3

    TSHZ2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSHZ2 (see all 11730)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360961831,2
    C--48654196(+) AAAAAG/-ATCAA 2 -- int11Minor allele frequency- -:0.50NA 2
    rs114705951,2
    C--48715027(+) TTTTT-/G/T/  
      TT
    /TTT
    GCTCT
    2 -- int12NA 4
    rs1439318961,2
    --51586995(+) GCAGGC/TGTATA 1 -- us2k10--------
    rs354584141,2
    C--51587063(+) ATTGTA/GTAAAG 1 -- us2k14Minor allele frequency- G:0.15NA WA EA 360
    rs1378953361,2
    C--51587077(+) TGTGG-/TATA  
            
    TATAT
    1 -- us2k10--------
    rs571394291,2
    C--51587111(+) TATATA/GTATGT 1 -- us2k14Minor allele frequency- G:0.14WA NA EA 360
    rs1471838881,2
    --51587113(+) TATATA/GTGTGT 1 -- us2k10--------
    rs759040721,2
    F--51587245(+) TAACTC/TAGGAT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1823933391,2
    --51587246(+) AACTCA/GGGATC 1 -- us2k10--------
    rs1405317521,2
    --51587265(+) AATACC/TACACG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSHZ2 (51588946 - 51838946 bp, first 250kb of TSHZ2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TSHZ2 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677315CNV Deletion23128226
    esv2669822CNV Deletion23128226
    esv2656881CNV Deletion23128226
    esv2722530CNV Deletion23290073
    dgv794e199CNV Deletion23128226
    esv2557335CNV Deletion19546169
    esv2722532CNV Deletion23290073
    esv2722531CNV Deletion23290073
    esv2722529CNV Deletion23290073
    esv269587CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSHZ2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614118    OMIM disorders: --

    4 diseases for TSHZ2:    About MalaCards
    ovarian cancer    alzheimer's disease    prostate cancer    prostatitis


    TSHZ2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TSHZ2
    Human Genome Epidemiology (HuGE) Navigator: TSHZ2 (5 documents)

    Export disorders for TSHZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSHZ2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TSHZ2)
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    1. Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction. (PubMed id 19745106)1, 2, 4 Jenkins D.... Woolf A.S. (Nephrol. Dial. Transplant. 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y.... Buxbaum J.D. (PLoS ONE 2009)
    5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    6. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PubMed id 9671742)1, 3 Collins C.... Gray J.W. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    10. Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers. (PubMed id 21423795)1 Yamamoto M....Yamamoto F. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 128553 HGNC: 13010 AceView: C20orf17 Ensembl:ENSG00000182463 euGenes: HUgn128553
    ECgene: TSHZ2 H-InvDB: TSHZ2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSHZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSHZ2 gene:
    Search GeneIP for patents involving TSHZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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