Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TSHZ1 Gene

protein-coding   GIFtS: 50
GCID: GC18P072922

Teashirt Zinc Finger Homeobox 1

(Previous names: serologically defined colon cancer antigen 33, teashirt...)
(Previous symbol: SDCCAG33)
  See TSHZ1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Teashirt Zinc Finger Homeobox 11 2     CAA2 5
Serologically Defined Colon Cancer Antigen 331 2 3     Teashirt Family Zinc Finger 11
SDCCAG331 2 3     Teashirt Zinc Finger 11
TSH12 3 5     NY-CO-332
Antigen NY-CO-332 3     Teashirt Homolog 12

External Ids:    HGNC: 106691   Entrez Gene: 101942   Ensembl: ENSG000001799817   OMIM: 6144275   UniProtKB: Q6ZSZ63   

Export aliases for TSHZ1 gene to outside databases

Previous GC identifers: GC18P071051 GC18P069607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TSHZ1 Gene:
This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression
libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be
involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with
congenital aural atresia syndrome. (provided by RefSeq, Jan 2012)

GeneCards Summary for TSHZ1 Gene:
TSHZ1 (teashirt zinc finger homeobox 1) is a protein-coding gene. Diseases associated with TSHZ1 include congenital aural atresia, and colon cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TSHZ3.

UniProtKB/Swiss-Prot: TSH1_HUMAN, Q6ZSZ6
Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional
repressor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSHZ1 gene promoter:
         GR   Sox5   GATA-3   GR-beta   FOXD3   LCR-F1   GATA-2   GATA-1   GR-alpha   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TSHZ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSHZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

TSHZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHZ1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P072922:  view genomic region     (about GC identifiers)

Start:
72,922,710 bp from pter      End:
73,001,905 bp from pter
Size:
79,196 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TSH1_HUMAN, Q6ZSZ6 (See protein sequence)
Recommended Name: Teashirt homolog 1  
Size: 1077 amino acids; 117916 Da
Subunit: Interacts (via homeobox domain) with APBB1 (via PID domain 1) (By similarity)
Sequence caution: Sequence=AAC18047.1; Type=Frameshift; Positions=304, 1048; Sequence=BAE06124.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60534 Q4LE29 Q53EU4
Alternative splicing: 2 isoforms:  Q6ZSZ6-1   Q6ZSZ6-2   

Explore the universe of human proteins at neXtProt for TSHZ1: NX_Q6ZSZ6

Explore proteomics data for TSHZ1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSHZ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005777.3  
    ENSEMBL proteins: 
     ENSP00000323584   ENSP00000464391   ENSP00000453834   ENSP00000452718  

    TSHZ1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TSHZ1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TSHZ1
    GenScript Custom Purified and Recombinant Proteins Services for TSHZ1
    Novus Biologicals TSHZ1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSHZ1

     
    Search eBioscience for Proteins for TSHZ1 

     
    antibodies-online proteins for TSHZ1 (2 products) 

     
    antibodies-online peptides for TSHZ1

    TSHZ1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TSHZ1
    OriGene Custom Antibody Services for TSHZ1
    Novus Biologicals TSHZ1 Antibodies
    Abcam antibodies for TSHZ1
    Cloud-Clone Corp. Antibodies for TSHZ1
    ThermoFisher Antibodies for TSHZ1
    antibodies-online antibodies for TSHZ1 (29 products) 

    TSHZ1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSHZ1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSHZ1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSHZ1
    Cloud-Clone Corp. CLIAs for TSHZ1
    Search eBioscience for ELISAs for TSHZ1 
    antibodies-online kits for TSHZ1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class
    TSHZ: Teashirt zinc fingers
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR027008 Teashirt_fam
     IPR015880 Znf_C2H2-like
     IPR026808 Tshz1
     IPR001356 Homeobox_dom
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZSZ6

    ProtoNet protein and cluster: Q6ZSZ6

    UniProtKB/Swiss-Prot: TSH1_HUMAN, Q6ZSZ6
    Similarity: Belongs to the teashirt C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with TSHZ1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSH1_HUMAN, Q6ZSZ6
    Function: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional
    repressor (Potential)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TSHZ1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TSHZ1:
     Decreased Hepatitis C virus re 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tshz1):
     behavior/neurological  craniofacial  digestive/alimentary  hearing/vestibular/ear  mortality/aging 
     respiratory system  skeleton 

    Find genes that share phenotypes with TSHZ1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tshz1tm1Core for TSHZ1

       genOway: Develop your customized and physiologically relevant rodent model for TSHZ1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TSHZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSHZ1 (see all 48):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-301a hsa-miR-764 hsa-miR-570 hsa-miR-124 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidTSHZ1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSHZ1
    Predesigned siRNA for gene silencing in human, mouse, rat TSHZ1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSHZ1

    Clone
    Products:
         
    OriGene clones in human, mouse for TSHZ1 (see all 8)
    OriGene ORF clones in mouse, rat for TSHZ1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSHZ1 (NM_005786)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHZ1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSHZ1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TSHZ1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TSH1_HUMAN, Q6ZSZ6: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with TSHZ1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including TSHZ1: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TSHZ1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TSHZ1 (Q6ZSZ63 ENSP000003235844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002133, ENSP000002994024I2D: score=1 STRING: ENSP00000299402
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0010468regulation of gene expression ----
    GO:0042474middle ear morphogenesis IEA--

    Find genes that share ontologies with TSHZ1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSHZ1 (TSH1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TSHZ1 gene: 
    NM_005786.5  

    Unigene Cluster for TSHZ1:

    Teashirt zinc finger homeobox 1
    Hs.284217  [show with all ESTs]
    Unigene Representative Sequence: AB210042
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322038(uc002lly.3) ENST00000580243 ENST00000560918 ENST00000560661
    ENST00000584217(uc021uln.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSHZ1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSHZ1 (see all 48):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-379* hsa-miR-301a hsa-miR-764 hsa-miR-570 hsa-miR-124 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidTSHZ1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSHZ1
    Predesigned siRNA for gene silencing in human, mouse, rat TSHZ1
    Clone
    Products:
         
    OriGene clones in human, mouse for TSHZ1 (see all 8)
    OriGene ORF clones in mouse, rat for TSHZ1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSHZ1 (NM_005786)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHZ1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TSHZ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSHZ1
      QuantiTect SYBR Green Assays in human, mouse, rat TSHZ1
      QuantiFast Probe-based Assays in human, mouse, rat TSHZ1

    Additional mRNA sequence: 

    AB210042.1 AF039698.1 AK127042.1 AK223545.1 AL833321.1 BC010679.2 BC024152.2 

    9 DOTS entries:

    DT.114292  DT.97794820  DT.102827466  DT.95273705  DT.40198231  DT.100009543  DT.91663127  DT.95273704 
    DT.92002331 

    Selected AceView cDNA sequences (see all 121):

    CF242878 CA489263 BQ272550 AA426522 AI090811 AA127183 N73862 AL833321 
    AA127184 N48543 BU501843 AW614927 CA448119 AA975279 BU689131 AI363032 
    BC010679 CD518667 N43873 BF477380 NM_005786 D61613 BM668248 AW293262 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TSHZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTCTTGA
    TSHZ1 Expression
    About this image


    TSHZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     NULL (Uncategorized)
             Neural rosettes
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    TSHZ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSHZ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284217

    UniProtKB/Swiss-Prot: TSH1_HUMAN, Q6ZSZ6
    Tissue specificity: Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease

        Pathway & Disease-focused RT2 Profiler PCR Array including TSHZ1: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TSHZ1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSHZ1
    QuantiTect SYBR Green Assays in human, mouse, rat TSHZ1
    QuantiFast Probe-based Assays in human, mouse, rat TSHZ1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TSHZ1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tshz11 , 5 teashirt zinc finger family member 11, 5 85.77(n)1
    92.73(a)1
      18 (57.53 cM)5
    1107961  NM_001081300.11  NP_001074769.11 
     840116285 
    chicken
    (Gallus gallus)
    Aves TSHZ11 teashirt zinc finger homeobox 1 77.99(n)
    88.06(a)
      428513  XM_426067.3  XP_426067.3 
    lizard
    (Anolis carolinensis)
    Reptilia TSHZ16
    teashirt zinc finger homeobox 1
    81(a)
    1 ↔ 1
    4(49803101-49895215)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.144302 Transcribed sequence 80.55(n)    BX698934.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sdccag332 serologically defined colon cancer antigen 33 78.03(n)   369196  AF242292.1 


    ENSEMBL Gene Tree for TSHZ1 (if available)
    TreeFam Gene Tree for TSHZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TSHZ1 gene
    TSHZ32  TSHZ22  
    2 SIMAP similar genes for TSHZ1 using alignment to 4 protein entries:     TSH1_HUMAN (see all proteins):
    TSHZ2    TSHZ3

    Find genes that share paralogs with TSHZ1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TSHZ1 (see all 1881)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3743942321,2
    C--69607657(+) GTTTG-/AG/G  
            
    GGGGG
    2 -- ut510--------
    rs1502175321,2
    C--69634602(+) ctttc-/TTTCATTT/TTTTA
    TTT
    /TTTTATTTATTT
    attta
    2 -- int1 cds10--------
    rs118748501,2
    H--69639175(+) AGGCAC/GTTACT 1 -- int10--------
    rs2017591061,2
    C--72774728(+) TCAGGG/TTGACG 1 -- us2k10--------
    rs2008888301,2
    C--72774772(+) ACCAGA/CTTCTG 1 -- us2k10--------
    rs1998526671,2
    C--72774971(+) TAGGG-/GGGCGG 1 -- us2k10--------
    rs1819177651,2
    --72775175(+) GGTGTC/TCCGGC 1 -- us2k10--------
    rs14402981,2
    C,F--72775518(+) TCCTTG/CCAAGG 1 -- us2k14Minor allele frequency- C:0.05MN NA WA 308
    rs1857224381,2
    --72775589(+) GGGCGA/GGGAGC 1 -- us2k10--------
    rs1421212721,2
    --72775599(+) CCCTG-/CCCGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSHZ1 (72922710 - 73001905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TSHZ1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458299CNV Loss19166990
    nsv132104CNV Loss16902084
    nsv132006CNV Loss16902084
    nsv833695CNV Gain17160897
    nsv909924CNV Gain21882294

    Human Gene Mutation Database (HGMD): TSHZ1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSHZ1
    DNA2.0 Custom Variant and Variant Library Synthesis for TSHZ1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614427   
    OMIM disorders: 607842  
    UniProtKB/Swiss-Prot: TSH1_HUMAN, Q6ZSZ6
  • Aural atresia, congenital (CAA) [MIM:607842]: A rare anomaly of the ear that involves some degree of
    failure of the development of the external auditory canal. The malformation can also involve the tympanic
    membrane, ossicles and middle ear space. The inner ear development is most often normal. Different CAA forms are
    known. CAA type I is characterized by bony or fibrous atresia of the lateral part of the external auditory canal
    and an almost normal medial part and middle ear. CAA type II is the most frequent type and is characterized by
    partial or total aplasia of the external auditory canal. CAA type IIA involves an external auditory canal with
    either complete bony atresia of the medial part or partial aplasia that ends blindly in a fistula leading to a
    rudimentary tympanic membrane. CAA type IIB is characterized by bony stenosis of the total length of the external
    auditory canal. CAA type III involves bony atresia of the external auditory canal and a very small or absent
    middle-ear cavity. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 2 diseases for TSHZ1:    
    About MalaCards
    congenital aural atresia    colon cancer


    Find genes that share disorders with TSHZ1           About GenesLikeMe

    Genetic Association Database (GAD): TSHZ1
    Human Genome Epidemiology (HuGE) Navigator: TSHZ1 (1 document)

    Export disorders for TSHZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TSHZ1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TSHZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disruption of teashirt zinc finger homeobox 1 is associated with congenital aural atresia in humans. (PubMed id 22152683)1, 2 Feenstra I.... Cremers C.W. (Am. J. Hum. Genet. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. (PubMed id 19343227)1, 2 Kajiwara Y.... Buxbaum J.D. (PLoS ONE 2009)
    4. Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. (PubMed id 17586487)1, 3 CorAc N....Fasano L. (Dev. Biol. 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2 Scanlan M.J.... Old L.J. (Int. J. Cancer 1998)
    7. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    8. Genome-wide copy number profiling using a 100K SNP array reveals novel disease-related genes BORIS and TSHZ1 in juvenile angiofibroma. (PubMed id 21874228)1 Schick B....Wendler O. (Int. J. Oncol. 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10194 HGNC: 10669 AceView: SDCCAG33 Ensembl:ENSG00000179981 euGenes: HUgn10194
    ECgene: TSHZ1 H-InvDB: TSHZ1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TSHZ1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TSHZ1 gene:
    Search GeneIP for patents involving TSHZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TSHZ1   OriGene RNAi products in human, mouse, rat for TSHZ1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TSHZ1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TSHZ1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSHZ1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TSHZ1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSHZ1   OriGene Custom Protein Services for TSHZ1  

     
     
     Block miRNA regulation of human, mouse, rat TSHZ1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TSHZ1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSHZ1 Predesigned siRNA for gene silencing in human, mouse, rat TSHZ1
     QuantiFast Probe-based Assays in human, mouse, rat TSHZ1 QuantiTect SYBR Green Assays in human, mouse, rat TSHZ1
     PCR Arrays including human, mouse, rat TSHZ1 Search Chromatin IP Primers for TSHZ1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSHZ1  Search GeneGlobe Interaction Network for TSHZ1
     Regulatory tfbs in TSHZ1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TSHZ1 GenScript cDNA clones with any tag delivered in your preferred vector for TSHZ1
     GenScript Custom Assay Services for TSHZ1 GenScript Custom overexpressing Cell Line Services for TSHZ1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TSHZ1 (TSH1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TSHZ1 antibodies
     TSHZ1 proteins
     Antibodies for TSHZ1
     See all of Abcam's Antibodies, Kits and Proteins for TSHZ1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TSHZ1
     Antibodies for TSHZ1
     ELISAs for TSHZ1
     CLIAs for TSHZ1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TSHZ1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHZ1
     SwitchGear 3'UTR luciferase reporter plasmids for TSHZ1
     Browse SwitchGear Promoter luciferase reporter plasmids for TSHZ1
     ThermoFisher Antibodies for TSHZ1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHZ1
     Browse compounds at ApexBio
     Search Addgene for plasmids for TSHZ1
      Search eBioscience for proteins for TSHZ1
      Search eBioscience for elisas for TSHZ1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TSHZ1
     antibodies-online antibodies for TSHZ1 (29 products)
     antibodies-online kits for TSHZ1 (4 products)
     antibodies-online peptides for TSHZ1
     antibodies-online proteins for TSHZ1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSHZ1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4