Aliases for TSHR Gene
External Ids for TSHR Gene
Previous GeneCards Identifiers for TSHR Gene
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for TSHR Gene
TSHR (Thyroid Stimulating Hormone Receptor) is a Protein Coding gene. Diseases associated with TSHR include familial hyperthyroidism due to mutations in tsh receptor and hypothyroidism due to tsh receptor mutations. Among its related pathways are Signaling by GPCR and Arf6 trafficking events. GO annotations related to this gene include G-protein coupled receptor activity and thyroid-stimulating hormone receptor activity. An important paralog of this gene is LGR6.
UniProtKB/Swiss-Prot for TSHR Gene
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).