Aliases for TSHR Gene
External Ids for TSHR Gene
Previous GeneCards Identifiers for TSHR Gene
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for TSHR Gene
TSHR (Thyroid Stimulating Hormone Receptor) is a Protein Coding gene. Diseases associated with TSHR include Hypothyroidism, Congenital, Nongoitrous, 1 and Hyperthyroidism, Nonautoimmune. Among its related pathways are Signaling by GPCR and Arf6 trafficking events. GO annotations related to this gene include G-protein coupled receptor activity and thyroid-stimulating hormone receptor activity. An important paralog of this gene is LHCGR.
UniProtKB/Swiss-Prot for TSHR Gene
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).