Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSHR Gene

protein-coding   GIFtS: 66
GCID: GC14P081421

Thyroid Stimulating Hormone Receptor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thyroid Stimulating Hormone Receptor1 2     Thyrotropin Receptor2
LGR32 3     Thyrotropin Receptor-I, HTSHR-I2
CHNG12 5     TSH-R3
hTSHR-I2     Thyroid-Stimulating Hormone Receptor3
Seven Transmembrane Helix Receptor2     

External Ids:    HGNC: 123731   Entrez Gene: 72532   Ensembl: ENSG000001654097   OMIM: 6033725   UniProtKB: P164733   

Export aliases for TSHR gene to outside databases

Previous GC identifers: GC14P078927 GC14P075238 GC14P079411 GC14P080491 GC14P061589


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSHR Gene:
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The
encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate
cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for TSHR Gene: 
TSHR (thyroid stimulating hormone receptor) is a protein-coding gene. Diseases associated with TSHR include hyperthyroidism, and multinodular goiter, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include protein binding and thyroid-stimulating hormone receptor activity. An important paralog of this gene is LHCGR.

UniProtKB/Swiss-Prot: TSHR_HUMAN, P16473
Function: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of
this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for
thyrostimulin (GPA2+GPB5)

Gene Wiki entry for TSHR (Thyrotropin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSHR gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSHR promoter sequence
   Search SABiosciences Chromatin IP Primers for TSHR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSHR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31   Ensembl cytogenetic band:  14q31.1   HGNC cytogenetic band: 14q24-q31

TSHR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHR gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P081421:  view genomic region     (about GC identifiers)

Start:
81,421,333 bp from pter      End:
81,612,646 bp from pter
Size:
191,314 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSHR_HUMAN, P16473 (See protein sequence)
Recommended Name: Thyrotropin receptor precursor  
Size: 764 amino acids; 86830 Da
Subunit: Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAA70232.1; Type=Frameshift; Positions=130, 135, 612;
3 PDB 3D structures from and Proteopedia for TSHR:
1XUM (3D)        2XWT (3D)        3G04 (3D)    
Secondary accessions: A0PJU7 G3V2A9 Q16503 Q8TB90 Q96GT6 Q9P1V4 Q9ULA3 Q9UPH3
Alternative splicing: 3 isoforms:  P16473-1   P16473-2   P16473-3   (No experimental confirmation available. Ref.9 (AAI27629) sequence is in conflict in position: 269:R->S)

Explore the universe of human proteins at neXtProt for TSHR: NX_P16473

Explore proteomics data for TSHR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16473

  • TSHR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSHR Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000360.2  NP_001018046.1  NP_001136098.1  

    ENSEMBL proteins: 
     ENSP00000441235   ENSP00000340113   ENSP00000451092   ENSP00000451202   ENSP00000450549  
     ENSP00000298171  
    Reactome Protein details: P16473
    Human Recombinant Protein Products for TSHR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TSHR
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TSHR
    GenScript Custom Purified and Recombinant Proteins Services for TSHR
    Novus Biologicals TSHR Protein
    Novus Biologicals TSHR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSHR 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8552586
    GO:0016021integral to membrane ----

    TSHR for ontologies           About GeneDecksing



    TSHR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TSHR (TSH R)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSHR
    GenScript Custom Superior Antibodies Services for TSHR
    Novus Biologicals TSHR Antibodies
    Abcam antibodies for TSHR
    Cloud-Clone Corp. Antibodies for TSHR 
    ThermoFisher Antibody for TSHR
    LSBio Antibodies in human, mouse, rat for TSHR 

    Assay Products for TSHR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSHR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSHR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSHR 
    Cloud-Clone Corp. CLIAs for TSHR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GTSHR: GPCR / Class A : Gonadotropin and TSH receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TSH receptor 
    Glycoprotein hormone receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002131 Gphrmn_rcpt
     IPR026906 LRR_5
     IPR002274 TSH_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P16473

    ProtoNet protein and cluster: P16473

    3 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB002131 Glycoprotein hormone receptor signature
    IPB002274 Thyrotropin receptor precursor signature


    UniProtKB/Swiss-Prot: TSHR_HUMAN, P16473
    Similarity: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily
    Similarity: Contains 7 LRR (leucine-rich) repeats


    TSHR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSHR_HUMAN, P16473
    Function: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of
    this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for
    thyrostimulin (GPA2+GPB5)

         Genatlas biochemistry entry for TSHR:
    thyroid stimulating hormone,receptor,G protein coupled receptor superfamily,thyroid hormone synthesis and
    metabolism pathway

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004996thyroid-stimulating hormone receptor activity IEA--
    GO:0005515protein binding IPI15775968
    GO:0016500protein-hormone receptor activity ----
         
    TSHR for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tshr):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     reproductive system 

    TSHR for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSHR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSHR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSHR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSHR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSHR
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TSHR:
    hsa-miR-3673 hsa-miR-3611 hsa-miR-196a* hsa-miR-3065-5p hsa-miR-143 hsa-miR-645 hsa-miR-205* hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidTSHR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSHR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSHR
    Sirion Biotech Customized adenovirus for overexpression of TSHR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TSHR (see all 16)
    OriGene ORF clones in mouse, rat for TSHR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TSHR (NM_000369)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHR
    Sirion Biotech Customized lentivirus for stable overexpression of TSHR 
                         Customized lentivirus expression plasmids for stable overexpression of TSHR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSHR
    Search LifeMap BioReagents cell lines for TSHR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TSHR About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.37
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Allograft rejection
    Autoimmune thyroid disease0.62
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Peptide GPCRs0.46
    5Insulin secretion
    Thyroid hormone synthesis0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for TSHR
        Arf6 signaling events
    Arf6 trafficking events
    Peptide GPCRs

    5/7        Reactome Pathways for TSHR (see all 7)
        GPCR downstream signaling
    Hormone ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    3         Kegg Pathways  (Kegg details for TSHR):
        Neuroactive ligand-receptor interaction
    Thyroid hormone synthesis
    Autoimmune thyroid disease


    TSHR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSHR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/92 Interacting proteins for TSHR (P164733 ENSP000002981714) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNBO753693, ENSP000002959564I2D: score=2 STRING: ENSP00000295956
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    HSPA5P110213, ENSP000003241734I2D: score=2 STRING: ENSP00000324173
    PIK3R1P279863, ENSP000002743354I2D: score=2 STRING: ENSP00000274335
    CALRP277973, ENSP000003208664I2D: score=1 STRING: ENSP00000320866
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8552586
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8552586
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway ----
    GO:0007267cell-cell signaling TAS7920658
    GO:0008284positive regulation of cell proliferation TAS7920658

    TSHR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TSHR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSHR

    1 HMDB Compound for TSHR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 DrugBank Compound for TSHR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Thyrotropin AlfaFollicle-stimulating hormone beta subunit (see all 4)9002-71-5targetagonist11752352 15571461 9039330

    2 IUPHAR Ligands for TSHR (TSH receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [125I]TSH
    AgonistFull agonist--
    TSH
    AgonistFull agonist--

    10/74 Novoseek inferred chemical compound relationships for TSHR gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methimazole 73.9 5 18964302 (1), 16571093 (1)
    mc 1-2 73.6 10 10411114 (2), 10487700 (2), 9528975 (2), 10958310 (1) (see all 5)
    thyroxine 72.5 15 10633214 (1), 17084554 (1), 10840997 (1), 7744989 (1) (see all 15)
    sodium iodide 70.3 19 10090312 (1), 12966202 (1), 17199440 (1), 12485453 (1) (see all 14)
    carbimazole 69.9 3 19141763 (1), 17042691 (1), 10646656 (1)
    iodine 68.9 29 16990652 (6), 19550078 (2), 15911145 (2), 11041453 (1) (see all 17)
    iodide 66.9 31 8981006 (2), 15691889 (2), 9398703 (1), 9413803 (1) (see all 20)
    propylthiouracil 59.9 4 8051490 (1), 12790806 (1), 15163329 (1)
    triiodothyronine 58.5 13 17287406 (1), 10840997 (1), 12790806 (1), 12899792 (1) (see all 9)
    adenylate 46.5 23 8147896 (2), 8137933 (2), 7702564 (2), 16335676 (2) (see all 17)

    Search CenterWatch for drugs/clinical trials and news about TSHR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSHR gene (3 alternative transcripts): 
    NM_000369.2  NM_001018036.2  NM_001142626.2  

    Unigene Cluster for TSHR:

    Thyroid stimulating hormone receptor
    Hs.160411  [show with all ESTs]
    Unigene Representative Sequence: NM_000369
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557096 ENST00000541158 ENST00000342443(uc001xvb.1 uc001xvc.3 uc010tvs.2)
    ENST00000553763 ENST00000555326 ENST00000554263 ENST00000554435 ENST00000556031
    ENST00000298171(uc001xvd.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSHR
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TSHR:
    hsa-miR-3673 hsa-miR-3611 hsa-miR-196a* hsa-miR-3065-5p hsa-miR-143 hsa-miR-645 hsa-miR-205* hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidTSHR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSHR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHR
    Clone
    Products:
         
    OriGene clones in human, mouse for TSHR (see all 16)
    OriGene ORF clones in mouse, rat for TSHR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TSHR (NM_000369)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHR
    Sirion Biotech Customized lentivirus for stable overexpression of TSHR 
                         Customized lentivirus expression plasmids for stable overexpression of TSHR 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TSHR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSHR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHR

    Additional mRNA sequence: 

    AB209207.1 AF035261.1 AK095769.1 AK303378.1 AY429111.1 BC009237.2 BC024205.2 BC063613.1 
    BC108653.1 BC120972.2 BC120973.2 BC127628.1 BC127629.1 BC141970.1 M31774.1 M32215.1 
    M73747.1 S45272.1 S49816.1 S82807.1 

    9 DOTS entries:

    DT.453667  DT.87046423  DT.91762220  DT.95161141  DT.120771538  DT.75184241  DT.99936172  DT.95368852 
    DT.99995997 

    24/46 AceView cDNA sequences (see all 46):

    AY429111 BE045816 BF036966 BC063613 AI142049 AI870633 BC024205 AF035261 
    NM_000369 BC009237 T29862 BF510960 AK095769 BX484832 M31774 BG207816 
    BE740743 AA384557 BE206608 BF034029 BF034165 M32215 BE272336 BE207611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSHR expression in normal human tissues (normalized intensities)      TSHR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSHR Expression
    About this image


    TSHR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Body Subcutaneous White Adipose
             epididymal fat pads   
     
     Thyroid (Endocrine System)
             Thyroid Progenitors ( Efficient derivation of purified lung and thyroid progenitor...
     
     Thymus (Hematopoietic System)
             Double Negative 3 Thymocytes Thymus
     
     Breast (Uncategorized)
             mammary gland   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See TSHR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSHR

    SOURCE GeneReport for Unigene cluster: Hs.160411

    UniProtKB/Swiss-Prot: TSHR_HUMAN, P16473
    Tissue specificity: Expressed in the thyroid

        SABiosciences Expression via Pathway-Focused PCR Arrays including TSHR: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TSHR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSHR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TSHR gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tshr1 , 5 thyroid stimulating hormone receptor1, 5 86.17(n)1
    86.78(a)1
      12 (44.51 cM)5
    220951  NM_011648.51  NP_035778.31 
     914009935 
    chicken
    (Gallus gallus)
    Aves TSHR1 thyroid stimulating hormone receptor 71.62(n)
    73.87(a)
      428900  NM_001193588.1  NP_001180517.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSHR6
    Uncharacterized protein
    71(a)
    1 ↔ 1
    1(17924371-17953600)
    zebrafish
    (Danio rerio)
    Actinopterygii tshr1 thyroid stimulating hormone receptor 63.15(n)
    61.46(a)
      560609  NM_001145763.1  NP_001139235.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fsh3 G-protein coupled receptor protein
    signaling pathway more
    37(a)
    (best of 2)
      3 90C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea C50H2.13 steroid hormone receptor 30(a)   V(9892549-9897216)   --


    ENSEMBL Gene Tree for TSHR (if available)
    TreeFam Gene Tree for TSHR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSHR gene
    LHCGR2  LGR52  FSHR2  RXFP12  LGR62  RXFP22  LGR42  
    2 SIMAP similar genes for TSHR using alignment to 5 protein entries:     TSHR_HUMAN (see all proteins):
    LHCGR    FSHR

    TSHR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TSHR_HUMAN, P16473
    Polymorphism: The Asp727Glu polymorphism is associated with Graves disease in a Russian population. The Glu727
    allele and the heterozygous Asp727Glu genotype are related to higher risk of the disease. The Asp727Glu
    polymorphism significantly ameliorates G(s)alpha protein activation in the presence of the gain-of-function
    mutation Ala593Asn although it is functionally inert in the context of the wild-type TSHR


    10/4179 SNPs in TSHR are shown (see all 4179)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0115264
    Hypothyroidism, congenital, non-goitrous, 1 (CHNG1)4--see VAR_0115262 D N mis40--------
    VAR_0035674
    Papillary cancer4--see VAR_0035672 F I mis40--------
    VAR_0115314
    Hyperthyroidism, non-autoimmune (HTNA)4--see VAR_0115312 I F mis40--------
    VAR_0115354
    Hyperthyroidism, non-autoimmune (HTNA)4--see VAR_0115352 V A mis40--------
    VAR_0115544
    Hyperthyroidism, non-autoimmune (HTNA)4--see VAR_0115542 N Y mis40--------
    VAR_0035684
    Papillary cancer4--see VAR_0035682 D E mis40--------
    VAR_0035664
    Familial gestational hyperthyroidism (HTFG)4--see VAR_0035662 K R mis40--------
    VAR_0172974
    Hypothyroidism, congenital, non-goitrous, 1 (CHNG1)4--see VAR_0172972 C R mis40--------
    VAR_0115384
    Hypothyroidism, congenital, non-goitrous, 1 (CHNG1)4--see VAR_0115382 A T mis40--------
    VAR_0035774
    Papillary cancer4--see VAR_0035772 K M mis40--------

    HapMap Linkage Disequilibrium report for TSHR (81421333 - 81612646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for TSHR (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748928CNV Deletion23290073
    esv2661838CNV Deletion23128226
    esv2748927CNV Deletion23290073
    esv2265006CNV Deletion18987734
    esv2036394CNV Deletion18987734
    esv2585992CNV Deletion19546169
    esv4614CNV Deletion18987735
    esv2748926CNV Deletion23290073
    esv2495579CNV Deletion19546169
    nsv1374CNV Insertion18451855


    Human Gene Mutation Database (HGMD): TSHR

    Locus Specific Mutation Databases (LSDB): TSHR
    5/15 SABiosciences Cancer Mutation PCR Assays for TSHR (see all 15):
    Cosmic IdAA Change
    26419p.D633Y
    26451p.I568T
    26420p.D633H
    26418p.T632I
    26415p.D619G
    3 SABiosciences Cancer Mutation PCR Arrays containing TSHR:
    Thyroid Cancer
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    SeqTarget long-range PCR primers for resequencing TSHR
    DNA2.0 Custom Variant and Variant Library Synthesis for TSHR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603372   
    OMIM disorders: 275200  609152  603373  
    UniProtKB/Swiss-Prot: TSHR_HUMAN, P16473
  • Note=Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies.
    Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been
    identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient
    areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and
    hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic
    multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different
    clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple
    hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by
    TSH-independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are
    also a cause of thyroid neoplasms (papillary and follicular cancers)
  • Note=Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of
    Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation
  • Hypothyroidism, congenital, non-goitrous, 1 (CHNG1) [MIM:275200]: A non-autoimmune condition
    characterized by resistance to thyroid-stimulating hormone (TSH) leading to increased levels of plasma TSH and
    low levels of thyroid hormone. It presents variable severity depending on the completeness of the defect. Most
    patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop
    hypothyroidism and present a hypoplastic thyroid gland. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Familial gestational hyperthyroidism (HTFG) [MIM:603373]: A condition characterized by abnormally high
    levels of serum thyroid hormones occurring during early pregnancy. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Hyperthyroidism, non-autoimmune (HTNA) [MIM:609152]: A condition characterized by abnormally high levels
    of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of
    Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the
    thyroid gland are absent. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/76 diseases for TSHR (see all 76):    About MalaCards
    hyperthyroidism    multinodular goiter    thyrotoxicosis    myxedema
    neonatal thyrotoxicosis    familial hyperthyroidism due to mutations in tsh receptor    hyperthyroidism, familial gestational    congenital hypothyroidism, nongoitrous 1
    hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia    toxic diffuse goiter    struma ovarii    neonatal hypothyroidism
    nontoxic goiter    transient congenital hypothyroidism    endemic goiter    thyroiditis
    goiter    mitral valve prolapse    thymic hyperplasia    graves' disease

    10 diseases from the University of Copenhagen DISEASES database for TSHR:
    Hyperthyroidism     Hypersensitivity reaction type II disease     Hypothyroidism     Goiter
    Thyroiditis     Thyrotoxicosis     Thyroid cancer     Adenoma
    Exophthalmos     Thyroid adenoma

    TSHR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/91 Novoseek inferred disease relationships for TSHR gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    graves disease 96.4 483 10365678 (6), 16235153 (4), 8636291 (4), 9920067 (4) (see all 99)
    hyperthyroidism 91.9 239 15284197 (4), 12240901 (4), 17129985 (3), 9589634 (3) (see all 99)
    autoimmune thyroid disease 89.9 58 10659563 (2), 9546816 (2), 7921224 (2), 19328414 (2) (see all 44)
    toxic adenoma 89.4 34 8626855 (4), 9525885 (1), 8549796 (1), 14514342 (1) (see all 25)
    thyroid-associated ophthalmopathy 86.1 20 14724083 (2), 16643732 (2), 9001189 (1), 12568121 (1) (see all 13)
    myxedema 86 23 1981364 (1), 9398703 (1), 10852437 (1), 12242030 (1) (see all 17)
    hashimotos thyroiditis 84.3 24 19850692 (2), 18942492 (2), 9183516 (2), 2226281 (1) (see all 19)
    tsh resistance 83.4 8 16135555 (2), 11379397 (1), 16060907 (1), 17237844 (1) (see all 6)
    thyroid diseases 82.5 54 12457447 (2), 18777457 (2), 10584424 (1), 16042141 (1) (see all 43)
    neonatal hyperthyroidism 82.1 6 10855389 (1), 19803950 (1), 12707626 (1), 8964822 (1) (see all 6)

    Genatlas disease: TSHR
    hypothyroidism,congenital,with high TSH,TSH unresponsiveness (TSHR defect in few cases),including thyroid
    hypoplasia

    Genetic Association Database (GAD): TSHR
    Human Genome Epidemiology (HuGE) Navigator: TSHR (53 documents)

    Export disorders for TSHR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSHR gene, integrated from 9 sources (see all 992):
    (articles sorted by number of sources associating them with TSHR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of Graves' disease with intragenic polymorphism of the thyrotropin receptor gene in a cohort of Singapore patients of multi- ethnic origins. (PubMed id 12930595)1, 2, 4, 9 Ho S.-C.... Khoo D.H. (2003)
    2. Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects. (PubMed id 12788902)1, 2, 4 Peeters R.P.... Visser T.J. (2003)
    3. A germline single nucleotide polymorphism at the intracellular domain of the human thyrotropin receptor does not have a major effect on the development of Graves' disease. (PubMed id 12593721)1, 2, 4 Ban Y.... Tomer Y. (2002)
    4. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. (PubMed id 2610690)1, 2, 3 Libert F.... Vassart G. (1989)
    5. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. (PubMed id 2558651)1, 2, 3 Nagayama Y.... Rapoport B. (1989)
    6. Thyrotropin receptor and thyroid transcription factor-1 genes variant in Chinese children with congenital hypothyroidism. (PubMed id 18379122)1, 4, 9 Yuan Z.F....Zhao Z.Y. (2008)
    7. A novel activating mutation in the thyrotropin receptor gene in an autonomously functioning thyroid nodule developed by a Japanese patient. (PubMed id 11022192)1, 2, 9 Kosugi S.... Mori T. (2000)
    8. The polymorphisms of codon 727 and 52 of thyroid-stimulating hormone receptor gene are not associated with mitral valve prolapse syndrome in Taiwan Chinese. (PubMed id 12558129)1, 4, 9 Chou H.T....Tsai F.J. (2002)
    9. Prevalence of TSH receptor and Gsalpha mutations in 4 5 autonomously functioning thyroid nodules in Japan. (PubMed id 19550078)1, 4, 9 Nishihara E....Miyauchi A. (2009)
    10. Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. (PubMed id 19244275)1, 4, 9 Brand O.J....Gough S.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7253 HGNC: 12373 AceView: TSHR Ensembl:ENSG00000165409 euGenes: HUgn7253
    ECgene: TSHR Kegg: 7253 H-InvDB: TSHR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSHR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSHR Genetics and Cytogenetics in Oncology and Haematology
    TSH receptor databasehttp://endokrinologie.uniklinikum-leipzig.de/tsh/
    GRIShttp://gris.ulb.ac.be/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TSHR
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TSHR
    Wikipedia http://en.wikipedia.org/wiki/TSH_receptor
    Sequence-structure-function-analysis of glycoprotein hormone receptorshttp://www.ssfa-gphr.de/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSHR gene:
    Search GeneIP for patents involving TSHR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TSHR (TSH R)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for TSHR (TSH R)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSHR  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TSHR  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TSHR  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSHR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TSHR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSHR   OriGene Custom Protein Services for TSHR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSHR
     QIAGEN SeqTarget long-range PCR primers for resequencing TSHR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSHR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHR
     GenScript Custom Purified and Recombinant Proteins Services for TSHR GenScript cDNA clones with any tag delivered in your preferred vector for TSHR
     GenScript Custom Assay Services for TSHR GenScript Custom Superior Antibodies Services for TSHR
     GenScript Custom overexpressing Cell Line Services for TSHR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSHR promoter
     Search Chromatin IP Primers for TSHR
     RT2 qPCR Primer Assay in human, mouse, rat TSHR
     GNC Network for TSHR
     SABiosciences PCR Arrays including human, mouse, rat TSHR
     Search Tocris compounds for TSHR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSHR antibodies
     TSHR proteins
     TSHR lysates
     Antibodies for TSHR
     See all of Abcam's Antibodies, Kits and Proteins for TSHR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TSHR
     Antibodies for TSHR
     ELISAs for TSHR
     CLIAs for TSHR
     Search LifeMap BioReagents cell lines for TSHR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHR
     SwitchGear 3'UTR luciferase reporter plasmids for TSHR
     SwitchGear Promoter luciferase reporter plasmids for TSHR
     ThermoFisher Antibody for TSHR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TSHR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSHR
    Customized:
     lentivirus for stable overexpression of TSHR
     lentivirus expression plasmids for stable overexpression of TSHR
     adenovirus for overexpression of TSHR
     LSBio Antibodies in human, mouse, rat for TSHR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSHR gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4