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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSHB Gene

protein-coding   GIFtS: 62
GCID: GC01P115572

Thyroid Stimulating Hormone, Beta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thyroid Stimulating Hormone, Beta1 2     TSH-beta3
Thyrotropin Beta Chain2 3     Thyroid-Stimulating Hormone Subunit Beta3
TSH-B2 3     Thyrotropin Alfa3
TSH-BETA2     CHNG45
Thyrotropin Subunit Beta2     

External Ids:    HGNC: 123721   Entrez Gene: 72522   Ensembl: ENSG000001342007   OMIM: 1885405   UniProtKB: P012223   

Export aliases for TSHB gene to outside databases

Previous GC identifers: GC01P115989 GC01P114458 GC01P114672 GC01P114874 GC01P114871 GC01P115284 GC01P113430


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSHB Gene:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating
hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are
associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are
unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid
structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone.
Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's
thyroiditis. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, May
2013)

GeneCards Summary for TSHB Gene: 
TSHB (thyroid stimulating hormone, beta) is a protein-coding gene. Diseases associated with TSHB include familial hypothyroidism, and tsh producing pituitary tumor, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include hormone activity. An important paralog of this gene is FSHB.

UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222
Function: Indispensable for the control of thyroid structure and metabolism

Gene Wiki entry for TSHB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSHB gene promoter:
         AP-1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   E4BP4   POU3F2   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSHB promoter sequence
   Search SABiosciences Chromatin IP Primers for TSHB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13

TSHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P115572:  view genomic region     (about GC identifiers)

Start:
115,572,415 bp from pter      End:
115,576,941 bp from pter
Size:
4,527 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222 (See protein sequence)
Recommended Name: Thyrotropin subunit beta precursor  
Size: 138 amino acids; 15639 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Subcellular location: Secreted
Secondary accessions: B1AKP0 Q16163

Explore the universe of human proteins at neXtProt for TSHB: NX_P01222

Explore proteomics data for TSHB at MOPED 

TSHB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TSHB Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_000540.2  NP_001264920.1  

ENSEMBL proteins: 
 ENSP00000358530   ENSP00000256592  
Reactome Protein details: P01222
Human Recombinant Protein Products for TSHB: 
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R&D Systems Recombinant & Natural Proteins for TSHB (TSH alpha/beta)
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OriGene Protein Over-expression Lysate for TSHB
OriGene Custom MassSpec 
OriGene Custom Protein Services for TSHB
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Novus Biologicals TSHB Protein
Novus Biologicals TSHB Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for TSHB
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--

TSHB for ontologies           About GeneDecksing



TSHB Antibody Products: 
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LSBio Antibodies in human, mouse, rat for TSHB 

Assay Products for TSHB: 
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GenScript Custom Assay Services for TSHB
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR018245 Gonadotropin_bsu_CS
 IPR006208 Cys_knot
 IPR001545 Gonadotropin_bsu

Graphical View of Domain Structure for InterPro Entry P01222

ProtoNet protein and cluster: P01222

3 Blocks protein domains:
IPB001545 Gonadotropin
IPB002400 Growth factor cystine knot superfamily signature
IPB006208 Cystine knot domain


UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222
Similarity: Belongs to the glycoprotein hormones subunit beta family


TSHB for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TSHB_HUMAN, P01222
Function: Indispensable for the control of thyroid structure and metabolism

     Genatlas biochemistry entry for TSHB:
thyroid stimulating hormone,beta polypeptide,thyroid hormones,secretion and metabolic pathway

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
     
TSHB for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for TSHB:
 Increased circadian period len  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TSHB 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSHB

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSHB 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSHB 

miRNA
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Inhib. RNA
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of TSHB

Clone
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GenScript: all cDNA clones in your preferred vector: TSHB (NM_000549)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHB
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Cell Line
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TSHB About   (see all 9)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Neuroactive ligand-receptor interaction0.37
GPCR ligand binding0.71
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Glycoprotein hormones
Glycoprotein hormones0.71
Hormone ligand-binding receptors0.33
Peptide hormone biosynthesis0.71
4Allograft rejection
Autoimmune thyroid disease0.62
5Insulin Processing
Peptide hormone metabolism0.39

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for TSHB
    TSH signaling pathway

5/11        Reactome Pathways for TSHB (see all 11)
    GPCR downstream signaling
Peptide hormone biosynthesis
Signaling by GPCR
GPCR ligand binding
Class A/1 (Rhodopsin-like receptors)


3         Kegg Pathways  (Kegg details for TSHB):
    Neuroactive ligand-receptor interaction
Thyroid hormone synthesis
Autoimmune thyroid disease


TSHB for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSHB

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TSHB (P012223 ENSP000002565924) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TSHRP164733, ENSP000002981714I2D: score=1 STRING: ENSP00000298171
CGAP012153, ENSP000003585954I2D: score=1 STRING: ENSP00000358595
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway TAS2792087
GO:0007267cell-cell signaling TAS2792087
GO:0009653anatomical structure morphogenesis TAS2792087
GO:0016486peptide hormone processing TAS--
GO:0033189response to vitamin A IEA--

TSHB for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TSHB for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSHB

UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222
Pharmaceutical: Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect
recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer

9 Novoseek inferred chemical compound relationships for TSHB gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thyroxine 53.6 2 11306166 (1)
ribonucleic acid 32.3 1 7543115 (1)
acth 25.2 8 8949563 (2), 8299588 (1), 1569173 (1), 12714791 (1)
chloramphenicol 21 2 11415853 (1), 1901656 (1)
retinoid 18.8 1 7775449 (1)
triiodothyronine 15.8 1 2329261 (1)
thymidine 6.28 2 11415853 (1), 1310694 (1)
estrogen 0 2 16133148 (1)
retinoic acid 0 1 7775449 (1)

Search CenterWatch for drugs/clinical trials and news about TSHB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSHB gene (2 alternative transcripts): 
NM_000549.4  NM_001277991.1  

Unigene Cluster for TSHB:

Thyroid stimulating hormone, beta
Hs.406687  [show with all ESTs]
Unigene Representative Sequence: AV752295
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000369517 ENST00000256592(uc001efs.1)
miRNA
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Inhib. RNA
Products:
     
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSHB
Clone
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OriGene clones in human, mouse for TSHB (see all 8)
OriGene ORF clones in mouse, rat for TSHB
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GenScript: all cDNA clones in your preferred vector: TSHB (NM_000549)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSHB
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSHB
Sirion Biotech Customized lentivirus for stable overexpression of TSHB 
                     Customized lentivirus expression plasmids for stable overexpression of TSHB 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for TSHB
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSHB
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSHB
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHB

Additional mRNA sequence: 

BC069298.1 S51112.1 

3 DOTS entries:

DT.108204  DT.97823333  DT.97824407 

5 AceView cDNA sequences:

BG202613 NM_000549 BC069298 AV745295 AV750117 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSHB expression in normal human tissues (normalized intensities)      TSHB embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGCCATCAA
TSHB Expression
About this image


TSHB expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Kidney (Urinary System)
         Podocytes Podocyte Layer

 -- (Endocrine System)
         pituitary gland   

See TSHB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSHB

SOURCE GeneReport for Unigene cluster: Hs.406687
    SABiosciences Custom PCR Arrays for TSHB
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSHB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSHB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TSHB gene from 6/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tshb1 , 5 thyroid stimulating hormone, beta subunit1, 5 83.57(n)1
84.78(a)1
  3 (45.25 cM)5
220941  NM_009432.21  NP_033458.21 
 1027773985 
chicken
(Gallus gallus)
Aves TSHB1 thyroid stimulating hormone, beta 70.51(n)
70.77(a)
  395937  NM_205063.1  NP_990394.1 
lizard
(Anolis carolinensis)
Reptilia TSHB6
Uncharacterized protein
61(a)
1 ↔ 1
4(130645499-130661220)
African clawed frog
(Xenopus laevis)
Amphibia L07618.12   -- 72.62(n)    L07618.1 
zebrafish
(Danio rerio)
Actinopterygii tshb1 thyroid stimulating hormone, beta subunit 56.18(n)
48.39(a)
  353223  NM_181494.2  NP_852471.1 
fruit fly
(Drosophila melanogaster)
Insecta Gpb56
Glycoprotein hormone beta 5
12(a)
1 → many
2LHet(167215-167979)


ENSEMBL Gene Tree for TSHB (if available)
TreeFam Gene Tree for TSHB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TSHB gene
FSHB2  CGB22  LHB2  CGB82  ENSG000002673352  CGB52  CGB2  CGB72  
CGB12  
8 SIMAP similar genes for TSHB using alignment to 1 protein entry:     TSHB_HUMAN:
FSHB    CGB    CGB2    CGB5    CGB8    CGB1
CGB7    LHB

TSHB for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/164 SNPs in TSHB are shown (see all 164)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219186701,2
Cpathogenic1115645623(+) TGTCCC/TAGGAT 4 Q * stg11Minor allele frequency- T:0.00NA 4550
rs1488899611,2
C--113431919(+) CTCTT-/AATC  
        
AATCA
1 -- int10--------
rs2004077161,2
C--113431919(+) ACTCTC/TAATCA 1 -- int10--------
rs3726582991,2
C--115571925(+) CCTCA-/AGGAGTC 1 -- us2k10--------
rs598026271,2
C--115573626(+) AATCA-/AAT   
  C
/ATCA
GATCT
1 -- int10--------
rs57772081,2
C--115575626(+) TTTTTT/-GCCTG 2 -- int1 us2k1 trp31Minor allele frequency- -:0.00NA 2
rs75308101,2
C,F,A,H--115639448(+) TGCATG/AGTATT 1 -- us2k111Minor allele frequency- A:0.40NS EA NA WA 668
rs1857714231,2
--115639502(+) CCATTA/GCATAT 1 -- us2k10--------
rs75540131,2
C,F,A--115639527(+) ACATAC/TATATA 1 -- us2k17Minor allele frequency- T:0.40NA WA CSA EA 365
rs1421660241,2
--115639558(+) AAATCC/TGCTAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TSHB (115572415 - 115576941 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TSHB:    About this table     
Variant IDTypeSubtypePubMed ID
nsv463295CNV Loss19166990
nsv528883CNV Loss19592680
esv26121CNV Loss19812545


Human Gene Mutation Database (HGMD): TSHB
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TSHB
DNA2.0 Custom Variant and Variant Library Synthesis for TSHB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 188540   
OMIM disorders: 275100  
20 diseases for TSHB:    About MalaCards
familial hypothyroidism    tsh producing pituitary tumor    congenital hypothyroidism, nongoitrous 4    hypothryoidism, congenital, nongoitrous 4
suprasellar meningioma    hypothyroidism    panhypopituitarism    hyperthyroidism
thyroiditis    pituitary tumors    combined pituitary hormone deficiency    congenital hypothyroidism
pituitary adenoma    autoimmune thyroiditis    meningioma    goiter
thyroid cancer    graves' disease    adenoma    hepatitis

6 diseases from the University of Copenhagen DISEASES database for TSHB:
Hypothyroidism     Pituitary adenoma     Adenoma     Suprasellar meningioma
Hyperthyroidism     Goiter

TSHB for disorders           About GeneDecksing

10 Novoseek inferred disease relationships for TSHB gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tsh deficiency 95 5 1811097 (1), 8254929 (1), 2401711 (1), 8196185 (1) (see all 5)
panhypopituitarism 82.5 1 18653712 (1)
congenital hypothyroidism 72.8 3 15292359 (1), 8848697 (1), 9806481 (1)
hypothyroidism 65.2 11 11297590 (2), 16804796 (2), 15297803 (2), 9039330 (1) (see all 7)
pituitary adenoma 65.2 3 7543115 (2), 9039330 (1)
pituitary tumors 64.7 1 7859921 (1)
adenoma 45.7 20 8949563 (5), 9820613 (4), 9666878 (1), 12714791 (1) (see all 5)
rare disease 13.1 1 16804796 (1)
hyperthyroidism 12.8 1 9039330 (1)
tumors 1.85 12 11081157 (3), 8077322 (2), 9003007 (1), 1310694 (1) (see all 5)

Genatlas disease: TSHB
hypothyroidism,pituitary,familial

Genetic Association Database (GAD): TSHB
Human Genome Epidemiology (HuGE) Navigator: TSHB (6 documents)

Export disorders for TSHB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TSHB gene, integrated from 9 sources (see all 145):
(articles sorted by number of sources associating them with TSHB)
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  1. The structure of the human thyrotropin beta-subunit gene. (PubMed id 3243440)1, 2, 3 Tatsumi K.... Matsubara K. (1988)
  2. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. (PubMed id 2457586)1, 2, 3 Wondisford F.E.... Weintraub B.D. (1988)
  3. Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe. (PubMed id 15297803)1, 4, 9 Karges B....Karges W. (2004)
  4. Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. (PubMed id 19837933)1, 4, 9 Atzmon G....Gabriely I. (2009)
  5. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect. (PubMed id 12364478)1, 4 Brumm H....Gruters A. (2002)
  8. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. (PubMed id 11140838)1, 4 Comings D.E....MacMurray J.P. (2000)
  9. Structure and regulation of human thyroid-stimulating hormone (TSH) gene. (PubMed id 8196184)1, 2 Miyoshi I.... Hayashizaki Y. (1994)
  10. The human thyrotropin beta-subunit gene differs in 5' structure from murine TSH-beta genes. (PubMed id 3234176)1, 2 Guidon P.T. Jr.... Kourides I.A. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7252 HGNC: 12372 AceView: TSHB Ensembl:ENSG00000134200 euGenes: HUgn7252
ECgene: TSHB Kegg: 7252 H-InvDB: TSHB

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TSHB Pharmacogenomics, SNPs, Pathways
Thyrogenhttp://www.thyrogen.com/home/thy_home.asp
Wikipedia http://en.wikipedia.org/wiki/Thyroid-stimulating_hormone

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TSHB gene:
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