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Aliases for TSHB Gene

Aliases for TSHB Gene

  • Thyroid Stimulating Hormone, Beta 2 3
  • Thyrotropin Beta Chain 3 4
  • TSH-BETA 3 4
  • TSH-B 3 4
  • Thyroid-Stimulating Hormone Subunit Beta 4
  • Thyrotropin Subunit Beta 3
  • Thyrotropin Alfa 4
  • CHNG4 6

External Ids for TSHB Gene

Previous GeneCards Identifiers for TSHB Gene

  • GC01P115989
  • GC01P114458
  • GC01P114672
  • GC01P114874
  • GC01P114871
  • GC01P115284
  • GC01P115572
  • GC01P113430

Summaries for TSHB Gene

Entrez Gene Summary for TSHB Gene

  • The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for TSHB Gene

TSHB (Thyroid Stimulating Hormone, Beta) is a Protein Coding gene. Diseases associated with TSHB include hypothryoidism, congenital, nongoitrous 4 and isolated thyroid-stimulating hormone deficiency. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB7.

UniProtKB/Swiss-Prot for TSHB Gene

  • Indispensable for the control of thyroid structure and metabolism

Gene Wiki entry for TSHB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSHB Gene

Genomics for TSHB Gene

Genomic Location for TSHB Gene

115,029,824 bp from pter
115,034,309 bp from pter
4,486 bases
Plus strand

Genomic View for TSHB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSHB Gene

Proteins for TSHB Gene

  • Protein details for TSHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyrotropin subunit beta
    Protein Accession:
    Secondary Accessions:
    • B1AKP0
    • Q16163

    Protein attributes for TSHB Gene

    138 amino acids
    Molecular mass:
    15639 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin

    Alternative splice isoforms for TSHB Gene


neXtProt entry for TSHB Gene

Proteomics data for TSHB Gene at MOPED

Post-translational modifications for TSHB Gene

Other Protein References for TSHB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TSHB Gene

Domains for TSHB Gene

Gene Families for TSHB Gene


Suggested Antigen Peptide Sequences for TSHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P01222
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with TSHB: view

Function for TSHB Gene

Molecular function for TSHB Gene

GENATLAS Biochemistry:
thyroid stimulating hormone,beta polypeptide,thyroid hormones,secretion and metabolic pathway
UniProtKB/Swiss-Prot Function:
Indispensable for the control of thyroid structure and metabolism

Gene Ontology (GO) - Molecular Function for TSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with TSHB: view

Phenotypes for TSHB Gene

genes like me logo Genes that share phenotypes with TSHB: view

Animal Model Products

miRNA for TSHB Gene

miRTarBase miRNAs that target TSHB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSHB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSHB Gene

Localization for TSHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSHB Gene


Subcellular locations from

Jensen Localization Image for TSHB Gene COMPARTMENTS Subcellular localization image for TSHB gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with TSHB: view

Pathways for TSHB Gene

genes like me logo Genes that share pathways with TSHB: view

Pathways by source for TSHB Gene

Interacting Proteins for TSHB Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000256592 P01222-TSHB_HUMAN for TSHB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 2792087
GO:0007267 cell-cell signaling TAS 2792087
GO:0009653 anatomical structure morphogenesis TAS 2792087
GO:0016486 peptide hormone processing TAS --
GO:0033189 response to vitamin A IEA --
genes like me logo Genes that share ontologies with TSHB: view

Compounds for TSHB Gene


Pharmaceutical: Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer

(9) Novoseek inferred chemical compound relationships for TSHB Gene

Compound -log(P) Hits PubMed IDs
thyroxine 53.6 1
ribonucleic acid 32.3 1
acth 25.2 5
chloramphenicol 21 2
retinoid 18.8 1
genes like me logo Genes that share compounds with TSHB: view

Transcripts for TSHB Gene

mRNA/cDNA for TSHB Gene

(3) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSHB Gene

Thyroid stimulating hormone, beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSHB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSHB Gene

No ASD Table

Relevant External Links for TSHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSHB Gene

mRNA expression in normal human tissues for TSHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSHB Gene

This gene is overexpressed in Pituitary (52.6).

SOURCE GeneReport for Unigene cluster for TSHB Gene Hs.406687

genes like me logo Genes that share expressions with TSHB: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TSHB Gene

Orthologs for TSHB Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSHB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSHB 35
  • 89.37 (n)
  • 88.41 (a)
  • 88 (a)
(Canis familiaris)
Mammalia TSHB 35
  • 91.79 (n)
  • 90.58 (a)
  • 79 (a)
(Mus musculus)
Mammalia Tshb 35
  • 83.57 (n)
  • 84.78 (a)
Tshb 16
Tshb 36
  • 85 (a)
(Pan troglodytes)
Mammalia TSHB 35
  • 99.02 (n)
  • 97.06 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Tshb 35
  • 82.48 (n)
  • 85.4 (a)
(Monodelphis domestica)
Mammalia TSHB 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia TSHB 36
  • 76 (a)
(Gallus gallus)
Aves TSHB 35
  • 70.51 (n)
  • 70.77 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia TSHB 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496349 35
  • 64.96 (n)
  • 60.58 (a)
(Danio rerio)
Actinopterygii tshb 35
  • 56.18 (n)
  • 48.39 (a)
tshb 36
  • 38 (a)
Species with no ortholog for TSHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSHB Gene

Gene Tree for TSHB (if available)
Gene Tree for TSHB (if available)

Paralogs for TSHB Gene

Paralogs for TSHB Gene

Selected SIMAP similar genes for TSHB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSHB: view

Variants for TSHB Gene

Sequence variations from dbSNP and Humsavar for TSHB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs140711 -- 115,029,307(-) AATGA(-/CT)CTCTG upstream-variant-2KB
rs1321107 -- 115,032,682(-) TTTAG(G/T)TCTAC intron-variant, upstream-variant-2KB
rs1321108 -- 115,029,744(-) TGATT(C/T)ACTGC upstream-variant-2KB
rs1321109 -- 115,029,295(-) GAACA(C/T)GGCCA upstream-variant-2KB
rs1852992 -- 115,032,762(-) ATATA(G/T)CATAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSHB Gene

Variant ID Type Subtype PubMed ID
nsv528883 CNV Loss 19592680
esv26121 CNV Loss 19812545
nsv463295 CNV Loss 19166990

Relevant External Links for TSHB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSHB Gene

Disorders for TSHB Gene

(1) OMIM Diseases for TSHB Gene (188540)

(10) Novoseek inferred disease relationships for TSHB Gene

Disease -log(P) Hits PubMed IDs
tsh deficiency 95 5
panhypopituitarism 82.5 1
congenital hypothyroidism 72.8 3
hypothyroidism 65.2 10
pituitary adenoma 65.2 3

Genatlas disease for TSHB Gene


Relevant External Links for TSHB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TSHB: view

No data available for UniProtKB/Swiss-Prot for TSHB Gene

Publications for TSHB Gene

  1. Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe. (PMID: 15297803) Karges B. … Karges W. (Horm. Res. 2004) 3 23 48
  2. A novel thyroid stimulating hormone beta-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid. (PMID: 19364510) Schaefer J.S. … Klein J.R. (Gen. Comp. Endocrinol. 2009) 3 4 23
  3. Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. (PMID: 19837933) Atzmon G. … Gabriely I. (J. Clin. Endocrinol. Metab. 2009) 3 23 48
  4. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. (PMID: 2457586) Wondisford F.E. … Weintraub B.D. (J. Biol. Chem. 1988) 2 3 4
  5. The structure of the human thyrotropin beta-subunit gene. (PMID: 3243440) Tatsumi K. … Matsubara K. (Gene 1988) 2 3 4

Products for TSHB Gene

Sources for TSHB Gene

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