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TSHB Gene

protein-coding   GIFtS: 63
GCID: GC01P115572

Thyroid Stimulating Hormone, Beta

  See TSHB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Stimulating Hormone, Beta1 2     TSH-beta3
Thyrotropin Beta Chain2 3     Thyroid-Stimulating Hormone Subunit Beta3
TSH-B2 3     Thyrotropin Alfa3
TSH-BETA2     CHNG45
Thyrotropin Subunit Beta2     

External Ids:    HGNC: 123721   Entrez Gene: 72522   Ensembl: ENSG000001342007   OMIM: 1885405   UniProtKB: P012223   

Export aliases for TSHB gene to outside databases

Previous GC identifers: GC01P115989 GC01P114458 GC01P114672 GC01P114874 GC01P114871 GC01P115284 GC01P113430


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSHB Gene:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating
hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are
associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are
unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid
structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone.
Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's
thyroiditis. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, May
2013)

GeneCards Summary for TSHB Gene:
TSHB (thyroid stimulating hormone, beta) is a protein-coding gene. Diseases associated with TSHB include congenital hypothyroidism, nongoitrous 4, and hypothryoidism, congenital, nongoitrous 4. GO annotations related to this gene include hormone activity. An important paralog of this gene is FSHB.

UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222
Function: Indispensable for the control of thyroid structure and metabolism

Gene Wiki entry for TSHB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSHB gene promoter:
         AP-1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   E4BP4   POU3F2   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSHB promoter sequence
   Search Chromatin IP Primers for TSHB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13

TSHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSHB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P115572:  view genomic region     (about GC identifiers)

Start:
115,572,415 bp from pter      End:
115,576,941 bp from pter
Size:
4,527 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222 (See protein sequence)
Recommended Name: Thyrotropin subunit beta precursor  
Size: 138 amino acids; 15639 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Secondary accessions: B1AKP0 Q16163
Alternative splicing: 2 isoforms:  P01222-1   P01222-2   (Major isoform in peripheral blood leukocytes and thyroid, may form heterodimers with isoform 1)

Explore the universe of human proteins at neXtProt for TSHB: NX_P01222

Explore proteomics data for TSHB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn43

  • See TSHB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000540.2  NP_001264920.1  

    ENSEMBL proteins: 
     ENSP00000358530   ENSP00000256592  
    Reactome Protein details: P01222

    TSHB Human Recombinant Protein Products:

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    Novus Biologicals TSHB Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TSHB
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for TSHB (18 products) 

     
    antibodies-online peptides for TSHB

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    antibodies-online antibodies for TSHB (177 products) 

    TSHB Assay Products:

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    antibodies-online kits for TSHB (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01222

    ProtoNet protein and cluster: P01222

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    Find genes that share domains with TSHB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSHB_HUMAN, P01222
    Function: Indispensable for the control of thyroid structure and metabolism

         Genatlas biochemistry entry for TSHB:
    thyroid stimulating hormone,beta polypeptide,thyroid hormones,secretion and metabolic pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
         
    Find genes that share ontologies with TSHB           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TSHB:
     Increased circadian period len  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TSHB

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSHB:
    hsa-mir-26b-5p (MIRT030150)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSHB_HUMAN, P01222: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with TSHB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSHB About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Thyroxine biosynthesis0.00
    Amine-derived hormones0.00
    5Allograft rejection
    Autoimmune thyroid disease0.61


    Find genes that share SuperPaths with TSHB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TSHB
        TSH signaling pathway


    4 Reactome Pathways for TSHB
        Thyroxine biosynthesis
    Hormone ligand-binding receptors
    Glycoprotein hormones
    G alpha (s) signalling events


    3 Kegg Pathways  (Kegg details for TSHB):
        Neuroactive ligand-receptor interaction
    Thyroid hormone synthesis
    Autoimmune thyroid disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSHB
    Interactions:

        GeneGlobe Interaction Network for TSHB

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TSHB (P012223 ENSP000002565924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSHRP164733, ENSP000002981714I2D: score=1 STRING: ENSP00000298171
    CGAP012153, ENSP000003585954I2D: score=1 STRING: ENSP00000358595
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS2792087
    GO:0007267cell-cell signaling TAS2792087
    GO:0009653anatomical structure morphogenesis TAS2792087
    GO:0016486peptide hormone processing TAS--
    GO:0033189response to vitamin A IEA--

    Find genes that share ontologies with TSHB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSHB

    UniProtKB/Swiss-Prot: TSHB_HUMAN, P01222
    Pharmaceutical: Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect
    recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer

    9 Novoseek inferred chemical compound relationships for TSHB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroxine 53.6 2 11306166 (1)
    ribonucleic acid 32.3 1 7543115 (1)
    acth 25.2 8 8949563 (2), 8299588 (1), 1569173 (1), 12714791 (1)
    chloramphenicol 21 2 11415853 (1), 1901656 (1)
    retinoid 18.8 1 7775449 (1)
    triiodothyronine 15.8 1 2329261 (1)
    thymidine 6.28 2 11415853 (1), 1310694 (1)
    estrogen 0 2 16133148 (1)
    retinoic acid 0 1 7775449 (1)



    Find genes that share compounds with TSHB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSHB gene (2 alternative transcripts): 
    NM_000549.4  NM_001277991.1  

    Unigene Cluster for TSHB:

    Thyroid stimulating hormone, beta
    Hs.406687  [show with all ESTs]
    Unigene Representative Sequence: AV752295
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369517 ENST00000256592(uc001efs.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TSHB
      QuantiFast Probe-based Assays in human, mouse, rat TSHB

    Additional mRNA sequence: 

    BC069298.1 S51112.1 

    3 DOTS entries:

    DT.108204  DT.97823333  DT.97824407 

    5 AceView cDNA sequences:

    BC069298 BG202613 NM_000549 AV745295 AV750117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCATCAA
    TSHB Expression
    About this image


    TSHB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
    TSHB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSHB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406687
        Custom PCR Arrays for TSHB
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TSHB gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tshb1 , 5 thyroid stimulating hormone, beta subunit1, 5 83.57(n)1
    84.78(a)1
      3 (45.25 cM)5
    220941  NM_001165939.11  NP_001159411.11 
     1027773985 
    chicken
    (Gallus gallus)
    Aves TSHB1 thyroid stimulating hormone, beta 70.51(n)
    70.77(a)
      395937  NM_205063.1  NP_990394.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSHB6
    thyroid stimulating hormone, beta
    62(a)
    1 ↔ 1
    4(130645499-130661220)
    African clawed frog
    (Xenopus laevis)
    Amphibia L07618.12   -- 72.62(n)    L07618.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tshb1 thyroid stimulating hormone, beta subunit 56.18(n)
    48.39(a)
      353223  NM_181494.2  NP_852471.1 


    ENSEMBL Gene Tree for TSHB (if available)
    TreeFam Gene Tree for TSHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSHB gene
    FSHB2  CGB22  LHB2  CGB82  ENSG000002673352  CGB52  CGB2  CGB72  
    CGB12  
    8 SIMAP similar genes for TSHB using alignment to 1 protein entry:     TSHB_HUMAN:
    FSHB    CGB    CGB1    CGB2    CGB5    CGB8
    CGB7    LHB

    Find genes that share paralogs with TSHB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSHB (see all 164)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219186701,2
    Cpathogenic1115645623(+) TGTCCC/TAGGAT 4 Q * stg11Minor allele frequency- T:0.00NA 4550
    rs1488899611,2
    C--113431919(+) CTCTT-/AATC  
            
    AATCA
    1 -- int10--------
    rs2004077161,2
    C--113431919(+) ACTCTC/TAATCA 1 -- int10--------
    rs3726582991,2
    C--115571925(+) CCTCA-/AGGAGTC 1 -- us2k10--------
    rs598026271,2
    C--115573626(+) AATCA-/AAT   
      C
    /ATCA
    GATCT
    1 -- int10--------
    rs57772081,2
    C--115575626(+) TTTTTT/-GCCTG 2 -- int1 us2k1 trp31Minor allele frequency- -:0.00NA 2
    rs75308101,2
    C,F,A,H--115639448(+) TGCATG/AGTATT 1 -- us2k111Minor allele frequency- A:0.40NS EA NA WA 668
    rs1857714231,2
    --115639502(+) CCATTA/GCATAT 1 -- us2k10--------
    rs75540131,2
    C,F,A--115639527(+) ACATAC/TATATA 1 -- us2k17Minor allele frequency- T:0.40NA WA CSA EA 365
    rs1421660241,2
    --115639558(+) AAATCC/TGCTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSHB (115572415 - 115576941 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TSHB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv463295CNV Loss19166990
    nsv528883CNV Loss19592680
    esv26121CNV Loss19812545

    Human Gene Mutation Database (HGMD): TSHB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSHB
    DNA2.0 Custom Variant and Variant Library Synthesis for TSHB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188540   
    OMIM disorders: 275100  
    10 diseases for TSHB:    
    About MalaCards
    congenital hypothyroidism, nongoitrous 4    hypothryoidism, congenital, nongoitrous 4    familial hypothyroidism    suprasellar meningioma
    thyroiditis    hyperthyroidism    panhypopituitarism    hypothyroidism
    pituitary tumors    meningioma

    6 diseases from the University of Copenhagen DISEASES database for TSHB:
    Hypothyroidism     Pituitary adenoma     Adenoma     Suprasellar meningioma
    Hyperthyroidism     Goiter

    Find genes that share disorders with TSHB           About GenesLikeMe

    10 Novoseek inferred disease relationships for TSHB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tsh deficiency 95 5 1811097 (1), 8254929 (1), 2401711 (1), 8196185 (1) (see all 5)
    panhypopituitarism 82.5 1 18653712 (1)
    congenital hypothyroidism 72.8 3 15292359 (1), 8848697 (1), 9806481 (1)
    hypothyroidism 65.2 11 11297590 (2), 16804796 (2), 15297803 (2), 9039330 (1) (see all 7)
    pituitary adenoma 65.2 3 7543115 (2), 9039330 (1)
    pituitary tumors 64.7 1 7859921 (1)
    adenoma 45.7 20 8949563 (5), 9820613 (4), 9666878 (1), 12714791 (1) (see all 5)
    rare disease 13.1 1 16804796 (1)
    hyperthyroidism 12.8 1 9039330 (1)
    tumors 1.85 12 11081157 (3), 8077322 (2), 9003007 (1), 1310694 (1) (see all 5)

    Genatlas disease: TSHB
    hypothyroidism,pituitary,familial

    Genetic Association Database (GAD): TSHB
    Human Genome Epidemiology (HuGE) Navigator: TSHB (6 documents)

    Export disorders for TSHB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSHB gene, integrated from 10 sources (see all 145):
    (articles sorted by number of sources associating them with TSHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure of the human thyrotropin beta-subunit gene. (PubMed id 3243440)1, 2, 3 Tatsumi K.... Matsubara K. (Gene 1988)
    2. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. (PubMed id 2457586)1, 2, 3 Wondisford F.E.... Weintraub B.D. (J. Biol. Chem. 1988)
    3. A novel thyroid stimulating hormone beta-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid. (PubMed id 19364510)1, 2, 9 Schaefer J.S. and Klein J.R. (Gen. Comp. Endocrinol. 2009)
    4. Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe. (PubMed id 15297803)1, 4, 9 Karges B....Karges W. (Horm. Res. 2004)
    5. Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity. (PubMed id 19837933)1, 4, 9 Atzmon G....Gabriely I. (J. Clin. Endocrinol. Metab. 2009)
    6. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect. (PubMed id 12364478)1, 4 Brumm H....GrA1ters A. (J. Clin. Endocrinol. Metab. 2002)
    9. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. (PubMed id 11140838)1, 4 Comings D.E....MacMurray J.P. (Clin. Genet. 2000)
    10. Structure and regulation of human thyroid-stimulating hormone (TSH) gene. (PubMed id 8196184)1, 2 Miyoshi I.... Hayashizaki Y. (Nippon Rinsho 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7252 HGNC: 12372 AceView: TSHB Ensembl:ENSG00000134200 euGenes: HUgn7252
    ECgene: TSHB Kegg: 7252 H-InvDB: TSHB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSHB Pharmacogenomics, SNPs, Pathways
    Thyrogenhttp://www.thyrogen.com/home/thy_home.asp
    Wikipedia http://en.wikipedia.org/wiki/Thyroid-stimulating_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSHB gene:
    Search GeneIP for patents involving TSHB

    GeneCards and IP:
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