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Aliases for TSGA10 Gene

Aliases for TSGA10 Gene

  • Testis Specific 10 2 3 5
  • Testis Development Protein NYD-SP7 3 4
  • Cancer/Testis Antigen 79 2 3
  • CEP4L 3 4
  • Testis-Specific Gene 10 Protein 3
  • CT79 3

External Ids for TSGA10 Gene

Previous GeneCards Identifiers for TSGA10 Gene

  • GC02M097495
  • GC02M098066
  • GC02M099218
  • GC02M099235
  • GC02M099613
  • GC02M093379

Summaries for TSGA10 Gene

GeneCards Summary for TSGA10 Gene

TSGA10 (Testis Specific 10) is a Protein Coding gene. Diseases associated with TSGA10 include Gemistocytic Astrocytoma. An important paralog of this gene is CEP135.

UniProtKB/Swiss-Prot for TSGA10 Gene

  • May play a role in the sperm tail fibrous sheath, a major sperm tail structure.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSGA10 Gene

Genomics for TSGA10 Gene

Regulatory Elements for TSGA10 Gene

Enhancers for TSGA10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TSGA10 on UCSC Golden Path with GeneCards custom track

Promoters for TSGA10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TSGA10 Gene

Chromosome:
2
Start:
98,997,261 bp from pter
End:
99,154,964 bp from pter
Size:
157,704 bases
Orientation:
Minus strand

Genomic View for TSGA10 Gene

Genes around TSGA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSGA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSGA10 Gene

Proteins for TSGA10 Gene

  • Protein details for TSGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZW7-TSG10_HUMAN
    Recommended name:
    Testis-specific gene 10 protein
    Protein Accession:
    Q9BZW7
    Secondary Accessions:
    • B7Z925
    • D3DVH7
    • Q8NEP0
    • Q9BWX0

    Protein attributes for TSGA10 Gene

    Size:
    698 amino acids
    Molecular mass:
    81421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSGA10 Gene

Post-translational modifications for TSGA10 Gene

  • Appears to be processed in a 27 kDa and a 55 kDa peptide containing respectively the N-terminal and the C-terminal part of the precursor.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSGA10 Gene

No data available for DME Specific Peptides for TSGA10 Gene

Domains & Families for TSGA10 Gene

Protein Domains for TSGA10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSGA10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZW7

UniProtKB/Swiss-Prot:

TSG10_HUMAN :
  • Belongs to the CEP135/TSGA10 family.
Family:
  • Belongs to the CEP135/TSGA10 family.
genes like me logo Genes that share domains with TSGA10: view

No data available for Gene Families for TSGA10 Gene

Function for TSGA10 Gene

Molecular function for TSGA10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the sperm tail fibrous sheath, a major sperm tail structure.

Gene Ontology (GO) - Molecular Function for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TSGA10: view

Phenotypes for TSGA10 Gene

GenomeRNAi human phenotypes for TSGA10:
genes like me logo Genes that share phenotypes with TSGA10: view

Animal Model Products

CRISPR Products

miRNA for TSGA10 Gene

miRTarBase miRNAs that target TSGA10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSGA10 Gene

Localization for TSGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSGA10 Gene

Cytoplasm. Nucleus. Nucleus membrane. Note=The 27 kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail while the 55 kDa peptide localizes to the midpiece. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSGA10 Gene COMPARTMENTS Subcellular localization image for TSGA10 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0031514 motile cilium IEA --
GO:0031965 nuclear membrane IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with TSGA10: view

Pathways & Interactions for TSGA10 Gene

SuperPathways for TSGA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 11179690
GO:0030031 cell projection assembly IEA --
genes like me logo Genes that share ontologies with TSGA10: view

No data available for Pathways by source and SIGNOR curated interactions for TSGA10 Gene

Drugs & Compounds for TSGA10 Gene

No Compound Related Data Available

Transcripts for TSGA10 Gene

Unigene Clusters for TSGA10 Gene

Testis specific, 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSGA10 Gene

No ASD Table

Relevant External Links for TSGA10 Gene

GeneLoc Exon Structure for
TSGA10
ECgene alternative splicing isoforms for
TSGA10

Expression for TSGA10 Gene

mRNA expression in normal human tissues for TSGA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSGA10 Gene

This gene is overexpressed in Testis (x13.5).

Protein differential expression in normal tissues from HIPED for TSGA10 Gene

This gene is overexpressed in Nasal epithelium (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSGA10 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSGA10 Gene:

TSGA10

SOURCE GeneReport for Unigene cluster for TSGA10 Gene:

Hs.120267

mRNA Expression by UniProt/SwissProt for TSGA10 Gene:

Q9BZW7-TSG10_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with TSGA10: view

Primer Products

No data available for Protein tissue co-expression partners for TSGA10 Gene

Orthologs for TSGA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSGA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSGA10 34
  • 93.28 (n)
  • 96.76 (a)
TSGA10 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSGA10 34
  • 94.61 (n)
  • 96.76 (a)
TSGA10 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsga10 34
  • 89 (n)
  • 95.55 (a)
Tsga10 16
Tsga10 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSGA10 34
  • 99.62 (n)
  • 99.57 (a)
TSGA10 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsga10 34
  • 88.59 (n)
  • 94.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TSGA10 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSGA10 34
  • 65.17 (n)
  • 55.64 (a)
TSGA10 35
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSGA10 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tsga10 34
  • 60.32 (n)
  • 51.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398577 34
zebrafish
(Danio rerio)
Actinopterygii tsga10 34
  • 51.64 (n)
  • 44.48 (a)
tsga10 35
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cep135 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for TSGA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSGA10 Gene

ENSEMBL:
Gene Tree for TSGA10 (if available)
TreeFam:
Gene Tree for TSGA10 (if available)

Paralogs for TSGA10 Gene

Paralogs for TSGA10 Gene

(1) SIMAP similar genes for TSGA10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSGA10: view

Variants for TSGA10 Gene

Sequence variations from dbSNP and Humsavar for TSGA10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1054042 -- 98,997,933(-) CTATT(A/C)TGTTC utr-variant-3-prime
rs1133977 -- 99,125,521(-) aacgg(A/C)tgtta intron-variant
rs1133978 -- 99,125,501(-) ggcaa(A/G)gactt intron-variant
rs4324365 -- 99,007,382(+) AGATA(G/T)ATTTA intron-variant
rs4340581 -- 99,108,562(+) TTTAA(C/T)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSGA10 Gene

Variant ID Type Subtype PubMed ID
esv2538757 CNV insertion 19546169
esv2720430 CNV deletion 23290073
esv2898 CNV loss 18987735
esv3306754 CNV mobile element insertion 20981092
esv3432571 CNV insertion 20981092
esv3559835 CNV deletion 23714750
esv3591732 CNV gain 21293372
esv8179 CNV loss 19470904
esv993745 OTHER inversion 20482838
nsv1071607 CNV deletion 25765185
nsv1138821 CNV deletion 24896259
nsv214239 CNV deletion 16902084
nsv2844 CNV deletion 18451855
nsv834310 CNV gain+loss 17160897
nsv954728 CNV deletion 24416366

Variation tolerance for TSGA10 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSGA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSGA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSGA10 Gene

Disorders for TSGA10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSGA10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gemistocytic astrocytoma
  • gemistocytic astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSGA10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSGA10
genes like me logo Genes that share disorders with TSGA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSGA10 Gene

Publications for TSGA10 Gene

  1. Identification and characterisation of a novel gene, TSGA10, expressed in testis. (PMID: 11179690) Modarressi M.H. … Wolfe J. (Gene 2001) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Over-expression of the testis-specific gene TSGA10 in cancers and its immunogenicity. (PMID: 15107545) Tanaka R. … Nakayama E. (Microbiol. Immunol. 2004) 3 22 65
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  5. Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma. (PMID: 24294352) Yuan X. … Gu J. (Int J Clin Exp Pathol 2013) 3 65

Products for TSGA10 Gene

Sources for TSGA10 Gene

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