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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSGA10 Gene

protein-coding   GIFtS: 46
GCID: GC02M099613

testis specific, 10
 Explore 11 diseases affiliated with
TSGA10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TSGA10    

Aliases
for TSGA10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Testis Specific, 101 2
CEP4L1 2 3
CT791 2
Testis Development Protein NYD-SP72 3
Cancer/Testis Antigen 792
Testis-Specific Gene 10 Protein2

External Ids:    HGNC: 149271   Entrez Gene: 807052   Ensembl: ENSG000001359517   OMIM: 6071665   UniProtKB: Q9BZW73   

Export aliases for TSGA10 gene to outside databases

Previous GC identifers: GC02M097495 GC02M098066 GC02M099218 GC02M099235 GC02M099072 GC02M093379


Summaries
for TSGA10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TSG10_HUMAN, Q9BZW7
Function: May play a role in the sperm tail fibrous sheath, a major sperm tail structure (By similarity)




Genomic Views
for TSGA10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSGA10 gene promoter:
         Pax-5   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Egr-4   MEF-2A   S8   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSGA10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSGA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSGA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

TSGA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSGA10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M099613:  view genomic region     (about GC identifiers)

Start:
 99,613,724 bp from pter      End:
 99,771,427 bp from pter
Size:
 157,704 bases      Orientation:
 minus strand

Proteins
for TSGA10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSG10_HUMAN, Q9BZW7 (See protein sequence)
Recommended Name: Testis-specific gene 10 protein  
Size: 698 amino acids; 81421 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Nucleus membrane (By similarity). Note=The 27
kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm
tail while the 55 kDa peptide localizes to the midpiece (By similarity)
Secondary accessions: D3DVH7 Q8NEP0 Q9BWX0

Explore the universe of human proteins at neXtProt for TSGA10: NX_Q9BZW7

Post-translational modifications:

  • Appears to be processed in a 27 kDa and a 55 kDa peptide containing respectively the N-terminal and the C-terminal part
    • of the precursor (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BZW7

    • TSGA10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_079520.1  NP_878915.2  

    ENSEMBL proteins: 
     ENSP00000377123   ENSP00000386956   ENSP00000347161   ENSP00000386508   ENSP00000377122  
     ENSP00000444419   ENSP00000445623  

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    Uscn Proteins for TSGA10

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--
    GO:0031965nuclear membrane IEA--
    GO:0043005neuron projection IEA--


    TSGA10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TSGA10

    Protein Domains /
    Families
    for TSGA10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9BZW7

    UniProtKB/Swiss-Prot: TSG10_HUMAN, Q9BZW7
    Similarity: Belongs to the CEP135/TSGA10 family


    Function
    for TSGA10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TSG10_HUMAN, Q9BZW7
    Function: May play a role in the sperm tail fibrous sheath, a major sperm tail structure (By similarity)

    miRNA
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    hsa-miR-181c hsa-miR-4328 hsa-miR-218-1* hsa-miR-4263 hsa-miR-1271 hsa-miR-3074-3p hsa-miR-3680 hsa-miR-3613-3p
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity ----


    TSGA10 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TSGA10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSGA10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/14 Interacting proteins for TSGA10 (Q9BZW72, 3 ENSP000003471614) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM29Q141342, 3, ENSP000003431294MINT-66562 I2D: score=5 STRING: ENSP00000343129
    HIF1AQ166652, 3, ENSP000003380184MINT-2635077 I2D: score=2 STRING: ENSP00000338018
    TUBA3CQ137483I2D: score=1 
    TUBA3DQ137483I2D: score=1 
    VIMP086703I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis TAS11179690
    GO:0030031cell projection assembly IEA--


    TSGA10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TSGA10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSGA10
    Search CenterWatch for drugs/clinical trials and news about TSGA10 / TSG10 

    Transcripts
    for TSGA10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TSGA10 gene (2 alternative transcripts): 
    NM_025244.2  NM_182911.3  

    Unigene Cluster for TSGA10:

    Testis specific, 10
    Hs.120267  [show with all ESTs]
    Unigene Representative Sequence: NM_025244
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000393483(uc002szg.4 uc002szh.4 uc002szi.4) ENST00000410001
    ENST00000355053 ENST00000489546 ENST00000409564(uc010yvn.1) ENST00000393482
    ENST00000478090 ENST00000488960 ENST00000489926 ENST00000497915 ENST00000471174
    ENST00000476849 ENST00000494483 ENST00000462782 ENST00000464459(uc002szj.1)
    ENST00000498097 ENST00000483914 ENST00000465216

    miRNA
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    hsa-miR-181c hsa-miR-4328 hsa-miR-218-1* hsa-miR-4263 hsa-miR-1271 hsa-miR-3074-3p hsa-miR-3680 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TSGA10 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF254756.1 AK304328.1 AK308951.1 AK313354.1 AY014284.1 BC028366.1 BX647157.1 

    17 DOTS entries:

    DT.207915  DT.86821151  DT.95197259  DT.120952339  DT.92035015  DT.95363750  DT.95285028  DT.92044355 
    DT.120952587  DT.40116705  DT.65287304  DT.91650420  DT.95242791  DT.120952502  DT.40125674  DT.92002341 
    DT.99927492 

    24/70 AceView cDNA sequences (see all 70):

    AW057728 NM_025244 AI024201 N33757 BX091273 AI240099 AF254756 BC028366 
    AI078488 AW591313 BF115639 BI831139 AY014284 AA393655 BQ417232 AK094208 
    BE044403 AI221135 BM968079 AI990237 BE888415 AA868661 CB989268 BX647157 

    GeneLoc Exon Structure


    Expression
    for TSGA10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSGA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TSGA10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TSGA10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSGA10

    SOURCE GeneReport for Unigene cluster: Hs.120267

    UniProtKB/Swiss-Prot: TSG10_HUMAN, Q9BZW7
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:     
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    Orthologs
    for TSGA10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TSGA10 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TSGA101 testis specific, 10 64.93(n)
    55.57(a)    		   418696  XM_416892.3  XP_416892.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TSGA106
    		 --
    		 45(a)
    		 1 ↔ 1
    		 GL343940.1(6174-40055)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3985772 similar to testis specific, 10 74.17(n)    BC048022.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tsga101 testis specific, 10 51.62(n)
    44.54(a)    		   768146  NM_001077289.2  NP_001070757.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cep1356
    		 --
    		 11(a)
    		 1 → many
    		 3L(15109837-15121129)


    ENSEMBL Gene Tree for TSGA10 (if available)
    TreeFam Gene Tree for TSGA10 (if available) 

    Paralogs
    for TSGA10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSGA10 gene
    CEP1352  
    1 SIMAP similar gene for TSGA10 using alignment to 4 protein entries:     TSG10_HUMAN (see all proteins):
    CEP135

    TSGA10 for paralogs           About GeneDecksing



    Genomic Variants
    for TSGA10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2333 NCBI SNPs in TSGA10 are shown (see all 2333)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1809755871,2
    		--99613250(+) CTTCCC/TTCATG 2 -- ds50010--------
    rs1387375341,2
    		--99613265(+) CTTCTC/TACATA 2 -- ds50010--------
    rs1835671341,2
    		--99613315(+) GTAACA/GTTCAG 2 -- ds50010--------
    rs1905798881,2
    		--99613329(+) TTTATC/TAGCTC 2 -- ds50010--------
    rs22788951,2
    		C,F,H,--99613484(+) TATAAG/AAGGGC 2 -- ds500113Minor allele frequency- A:0.46NS EA NA WA CSA 783
    rs1494273591,2
    		--99613521(+) AACCAA/GTCTGT 2 -- ds50010--------
    rs1438005451,2
    		--99613562(+) CAAAGA/GTTTTA 2 -- ds50010--------
    rs1823697171,2
    		--99613574(+) AAAAGA/CAAACC 2 -- ds50010--------
    rs1867957411,2
    		--99613580(+) AAACCA/TCAGTG 2 -- ds50010--------
    rs1916419751,2
    		--99613648(+) AAATCA/GGAGCA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TSGA10 (99613724 - 99771427 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for TSGA10
         10 CNVs: 4301 89833 97920 89832 89834 78665 89835 89831 78667 78666
         4 Indels: 42822 61800 40345 12088

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    Disorders / Diseases
    for TSGA10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TSGA10 for disorders           About GeneDecksing

    OMIM gene information: 607166    OMIM disorders: --

    11 diseases for TSGA10:    About MalaCards
    autoimmune polyendocrine syndrome type 1    autoimmune polyendocrine syndrome    gemistocytic astrocytoma    parapsoriasis
    systemic lupus erythematosus    lupus erythematosus    acute lymphoblastic leukemia    lymphoblastic leukemia
    leukemia    astrocytoma    hypoxia

    3 diseases from the University of Copenhagen DISEASES database for TSGA10:
    Gemistocytic astrocytoma     Parapsoriasis     Autoimmune polyendocrine syndrome type 1

    Export disorders for TSGA10 gene to outside databases

    Publications
    for TSGA10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSGA10 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TSGA10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterisation of a novel gene, TSGA10, expressed in testis. (PubMed id 11179690)1, 2, 3 Modarressi M.H.... Wolfe J. (2001)
    2. Over-expression of the testis-specific gene TSGA10 in cancers and its immunogenicity. (PubMed id 15107545)1, 9 Tanaka R....Nakayama E. (2004)
    3. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
    4. TSGA10 - A target for autoantibodies in autoimmune po lyendocrine syndrome type 1 and systemic lupus erythematosus. (PubMed id 21198756)1 Smith C.J....Bensing S. (2011)
    5. Filament-associated TSGA10 protein is expressed in pr ofessional antigen presenting cells and interacts with vimentin. (PubMed id 20797700)1 Roghanian A....Behnam B. (2010)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Testis-expressed protein TSGA10 an auto-antigen in autoimmune polyendocrine syndrome type I. (PubMed id 18000009)1 Reimand K....Uibo R. (2008)
    8. TSGA10 prevents nuclear localization of the hypoxia-i nducible factor (HIF)-1alpha. (PubMed id 16777103)1 HAogele S....Katschinski D.M. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Expression of the testis-specific gene, TSGA10, in Iranian patients with acute lymphoblastic leukemia (ALL). (PubMed id 16406020)1 Mobasheri M.B....Shokri F. (2006)

    External Searches for TSGA10 gene

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    Genome Databases showing TSGA10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80705 HGNC: 14927 AceView: TSGA10 Ensembl:ENSG00000135951 euGenes: HUgn80705
    ECgene: TSGA10 H-InvDB: TSGA10

    Other Databases showing TSGA10 gene

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    Specialized Databases showing TSGA10 gene

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    PharmGKB entry for TSGA10 Pharmacogenomics, SNPs, Pathways

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