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Aliases for TSGA10 Gene

Aliases for TSGA10 Gene

  • Testis Specific, 10 2 3
  • Testis Development Protein NYD-SP7 3 4
  • Cancer/Testis Antigen 79 2 3
  • CEP4L 3 4
  • Testis-Specific Gene 10 Protein 3
  • CT79 3

External Ids for TSGA10 Gene

Previous GeneCards Identifiers for TSGA10 Gene

  • GC02M097495
  • GC02M098066
  • GC02M099218
  • GC02M099235
  • GC02M099613
  • GC02M093379

Summaries for TSGA10 Gene

GeneCards Summary for TSGA10 Gene

TSGA10 (Testis Specific, 10) is a Protein Coding gene. Diseases associated with TSGA10 include parapsoriasis and gemistocytic astrocytoma. An important paralog of this gene is CEP135.

UniProtKB/Swiss-Prot for TSGA10 Gene

  • May play a role in the sperm tail fibrous sheath, a major sperm tail structure.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSGA10 Gene

Genomics for TSGA10 Gene

Regulatory Elements for TSGA10 Gene

Genomic Location for TSGA10 Gene

Start:
98,997,261 bp from pter
End:
99,154,964 bp from pter
Size:
157,704 bases
Orientation:
Minus strand

Genomic View for TSGA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSGA10 Gene

Proteins for TSGA10 Gene

  • Protein details for TSGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZW7-TSG10_HUMAN
    Recommended name:
    Testis-specific gene 10 protein
    Protein Accession:
    Q9BZW7
    Secondary Accessions:
    • B7Z925
    • D3DVH7
    • Q8NEP0
    • Q9BWX0

    Protein attributes for TSGA10 Gene

    Size:
    698 amino acids
    Molecular mass:
    81421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSGA10 Gene

Proteomics data for TSGA10 Gene at MOPED

Post-translational modifications for TSGA10 Gene

  • Appears to be processed in a 27 kDa and a 55 kDa peptide containing respectively the N-terminal and the C-terminal part of the precursor.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSGA10 Gene

No data available for DME Specific Peptides for TSGA10 Gene

Domains for TSGA10 Gene

Protein Domains for TSGA10 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TSGA10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZW7

UniProtKB/Swiss-Prot:

TSG10_HUMAN :
  • Q9BZW7
Family:
  • Belongs to the CEP135/TSGA10 family.
genes like me logo Genes that share domains with TSGA10: view

No data available for Gene Families for TSGA10 Gene

Function for TSGA10 Gene

Molecular function for TSGA10 Gene

UniProtKB/Swiss-Prot Function: May play a role in the sperm tail fibrous sheath, a major sperm tail structure.

Gene Ontology (GO) - Molecular Function for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TSGA10: view

miRNA for TSGA10 Gene

miRTarBase miRNAs that target TSGA10

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSGA10 Gene

Localization for TSGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSGA10 Gene

Cytoplasm. Nucleus. Nucleus membrane. Note=The 27 kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail while the 55 kDa peptide localizes to the midpiece. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSGA10 Gene COMPARTMENTS Subcellular localization image for TSGA10 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with TSGA10: view

Pathways for TSGA10 Gene

SuperPathways for TSGA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 11179690
GO:0030031 cell projection assembly IEA --
genes like me logo Genes that share ontologies with TSGA10: view

No data available for Pathways by source for TSGA10 Gene

Transcripts for TSGA10 Gene

Unigene Clusters for TSGA10 Gene

Testis specific, 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSGA10 Gene

No ASD Table

Relevant External Links for TSGA10 Gene

GeneLoc Exon Structure for
TSGA10
ECgene alternative splicing isoforms for
TSGA10

Expression for TSGA10 Gene

mRNA expression in normal human tissues for TSGA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSGA10 Gene

This gene is overexpressed in Testis (13.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TSGA10 Gene

SOURCE GeneReport for Unigene cluster for TSGA10 Gene Hs.120267

mRNA Expression by UniProt/SwissProt for TSGA10 Gene

Q9BZW7-TSG10_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expressions with TSGA10: view

Orthologs for TSGA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSGA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSGA10 35
  • 99.62 (n)
  • 99.57 (a)
TSGA10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSGA10 35
  • 93.28 (n)
  • 96.76 (a)
TSGA10 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSGA10 35
  • 94.61 (n)
  • 96.76 (a)
TSGA10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsga10 35
  • 89 (n)
  • 95.55 (a)
Tsga10 16
Tsga10 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSGA10 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsga10 35
  • 88.59 (n)
  • 94.96 (a)
chicken
(Gallus gallus)
Aves TSGA10 35
  • 65.17 (n)
  • 55.64 (a)
TSGA10 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSGA10 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398577 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tsga10 35
  • 60.32 (n)
  • 51.45 (a)
zebrafish
(Danio rerio)
Actinopterygii tsga10 35
  • 51.64 (n)
  • 44.48 (a)
tsga10 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cep135 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for TSGA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSGA10 Gene

ENSEMBL:
Gene Tree for TSGA10 (if available)
TreeFam:
Gene Tree for TSGA10 (if available)

Paralogs for TSGA10 Gene

Paralogs for TSGA10 Gene

Selected SIMAP similar genes for TSGA10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSGA10: view

Variants for TSGA10 Gene

Sequence variations from dbSNP and Humsavar for TSGA10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs540618 -- 99,048,744(-) tttag(C/T)ttaat intron-variant
rs720228 -- 99,088,084(-) tctag(C/T)tcttt intron-variant
rs720229 -- 99,087,810(-) tttgt(A/G)ggcat intron-variant
rs896884 -- 99,035,500(+) AACTA(C/T)AACAT intron-variant
rs896885 -- 99,035,653(+) GCAGG(A/G)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSGA10 Gene

Variant ID Type Subtype PubMed ID
nsv834310 CNV Gain+Loss 17160897
nsv2844 CNV Loss 18451855
esv993745 OTHER Inversion 20482838
esv271030 CNV Insertion 20981092
esv2538757 CNV Insertion 19546169
esv2898 CNV Deletion 18987735
esv2720430 CNV Deletion 23290073
nsv214239 CNV Loss 16902084
esv8179 CNV Loss 19470904

Relevant External Links for TSGA10 Gene

HapMap Linkage Disequilibrium report
TSGA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSGA10 Gene

Disorders for TSGA10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for TSGA10 Gene including...

Search for TSGA10 Gene in MalaCards »
genes like me logo Genes that share disorders with TSGA10: view

No data available for UniProtKB/Swiss-Prot for TSGA10 Gene

Publications for TSGA10 Gene

  1. Identification and characterisation of a novel gene, TSGA10, expressed in testis. (PMID: 11179690) Modarressi M.H. … Wolfe J. (Gene 2001) 2 3 4
  2. Over-expression of the testis-specific gene TSGA10 in cancers and its immunogenicity. (PMID: 15107545) Tanaka R. … Nakayama E. (Microbiol. Immunol. 2004) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TSGA10 Gene

Sources for TSGA10 Gene

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