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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TSG101 Gene

protein-coding GIFtS: 66
GCID: GC11M018501

tumor susceptibility gene 101

(Previous name: tumor susceptibility gene 10 )
(Previous symbol: TSG10)

Explore 46 diseases affiliated with
TSG101 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Susceptibility Gene 101¹ ²		Tumor Susceptibility Gene 10¹
TSG10¹ ²		Tumor Susceptibility Gene 101 Protein²
VPS23¹ ²		Tumor Susceptibility Protein²
ESCRT-I Complex Subunit TSG101² ³

External Ids:	HGNC: 15971¹	Entrez Gene: 7251²	Ensembl: ENSG00000074319⁷	OMIM: 601387⁵	UniProtKB: Q99816³

Export aliases for TSG101 gene to outside databases

Previous GC identifers: GC11M019623 GC11M019444 GC11M018541 GC11M018466 GC11M018458 GC11M018187

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSG101:

The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes.

The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in

tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator.

In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic

stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast

cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816

Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo

proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates

the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires

CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the

budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This

interaction is essential for viral particle budding of numerous retroviruses

Gene Wiki entry for TSG101

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TSG101 gene promoter:
GR GR-beta FOXD1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSG101 promoter sequence

Search SABiosciences Chromatin IP Primers for TSG101

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSG101

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15

TSG101 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSG101 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M018501: view genomic region (about GC identifiers)

Start:	18,489,883 bp from pter	End:	18,548,779 bp from pter
Size:	58,897 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816 (See protein sequence)

Recommended Name: Tumor susceptibility gene 101 protein

Size: 390 amino acids; 43944 Da

Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of

TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with VPS37A,

VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Interacts with HGS; the

interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV

domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with MVB12A; the

association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with

LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding. Interacts with

PDCD6. Interacts with HIV-1 p6. Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola

virus VP40. Interacts with EIAV p9; the interaction has been shown in vitro. Interacts with MGRN1

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral

membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the

stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis

6/13 PDB 3D structures from and Proteopedia for TSG101 (see all 13):

1KPP (3D)

1KPQ (3D)

1M4P (3D)

1M4Q (3D)

1S1Q (3D)

2F0R (3D)

Secondary accessions: Q9BUM5

Alternative splicing: 2 isoforms: Q99816-1 Q99816-2 (Detected in normal as well as cancer tissues)

Explore the universe of human proteins at neXtProt for TSG101: NX_Q99816

Post-translational modifications:

Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its

shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the

presence of UBE2D1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99816

TSG101 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006283.1

ENSEMBL proteins:

ENSP00000438471 ENSP00000464386 ENSP00000463213 ENSP00000251968 ENSP00000349721

Reactome Protein details: Q99816
Human Recombinant Protein Products:

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	Uscn Proteins for TSG101

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	ISS	--
GO:0005769	early endosome	IDA	17229889
GO:0005770	late endosome	IMP	15126635

TSG101 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TSG101

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TSG101 for domains About GeneDecksing

3 InterPro domains/families:

IPR016135 UBQ-conjugating_enzyme/RWD

IPR008883 UEV_N

IPR017916 Steadiness_box

Graphical View of Domain Structure for InterPro Entry Q99816

ProtoNet protein and cluster: Q99816

2 Blocks protein families:

IPB000608 Ubiquitin-conjugating enzymes

IPB008883 Tumour susceptibility gene 101

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816

Domain: The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction

with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein

Domain: The coiled coil domain may interact with stathmin

Domain: The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently

Similarity: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily

Similarity: Contains 1 SB (steadiness box) domain

Similarity: Contains 1 UEV (ubiquitin E2 variant) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816

Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo

proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates

the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires

CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the

budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This

interaction is essential for viral particle budding of numerous retroviruses

Genatlas biochemistry entry for TSG101:

murine tumor susceptibility gene 101 (Tsg101) homolog,43kDa,transcriptional suppressor for ESRR and other nuclear

hormone receptors,mutated in primary breast carcinoma,aberrantly spliced in small cell lung carcinoma and in

cervical,endometrial,hormone refractory prostate cancer,involved in cell cycle regulation

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		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TSG101 (see all 18):
		hsa-miR-106a hsa-miR-1285 hsa-miR-519a hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17 hsa-miR-20a

		SwitchGear 3'UTR luciferase reporter plasmid: TSG101 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSG101

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	10888872
GO:0003714	transcription corepressor activity	IEA	--
GO:0005515	protein binding	IPI	19060904
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	--	--
GO:0031625	ubiquitin protein ligase binding	IPI	17229889

TSG101 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for TSG101:

G0/1 arrest

Increased G1 DNA content

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for TSG101: Tsg101^tm1.1Kuw Tsg101^tm1Mak
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tsg101):

cellular	embryogenesis	endocrine/exocrine gland	growth/size	integument
mortality/aging	normal	tumorigenesis

TSG101 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal Transduction

	Assembly of HIV virion	0.36			Synthesis And Processing Of GAG, GAGPOL Polyproteins	0.36
	Membrane binding and targetting of GAG proteins	0.36			Endosomal Sorting Complex Required For Transport (ESCRT)	0.14

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

HIV Infection

HIV Infection

1.00

Disease

Disease

1.00

Membrane Trafficking

Membrane Trafficking

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TSG101

Breast Cancer Regulation by Stathmin1

2 GeneGo (Thomson Reuters) Pathways for TSG101

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / Sorting endosome formation in CF

2 BioSystems Pathways for TSG101

	Glucocorticoid receptor regulatory network
	Internalization of ErbB1

5/9 Reactome Pathways for TSG101 (see all 9)

	Late Phase of HIV Life Cycle
	Membrane Trafficking
	Synthesis And Processing Of GAG, GAGPOL Polyproteins
	Endosomal Sorting Complex Required For Transport (ESCRT)
	Disease

1 Kegg Pathway (Kegg details for TSG101):

Endocytosis

TSG101 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TSG101

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/882 Interacting proteins for TSG101 (Q99816^{1, 2, 3} ENSP00000251968⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 882)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEP55	Q53EZ4²^,³, ENSP00000360540⁴	MINT-6173601 MINT-6169549 MINT-6173584 MINT-6173720 MINT-6175155 MINT-6173676 MINT-6173387 MINT-6173737 MINT-6173542 I2D: score=5 STRING: ENSP00000360540
HGS	O14964²^,³, ENSP00000331201⁴	MINT-50310 MINT-50311 MINT-50312 MINT-50313 MINT-68474 I2D: score=8 STRING: ENSP00000331201
PDCD6IP	Q8WUM4²^,³, ENSP00000307387⁴	MINT-6173720 MINT-7945693 I2D: score=5 STRING: ENSP00000307387
DMAP1	Q9NPF5²^,³, ENSP00000312697⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000312697
VPS37B	Q9H9H4²^,³, ENSP00000267202⁴	MINT-6173737 MINT-6173772 I2D: score=3 STRING: ENSP00000267202

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0006464	cellular protein modification process	IEA	--
GO:0006513	protein monoubiquitination	--	--
GO:0007050	cell cycle arrest	IEA	--
GO:0008285	negative regulation of cell proliferation	IEA	--

TSG101 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TSG101 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSG101
7 Novoseek chemical compound relationships for TSG101 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ptap	95.2	16	12915533 (3), 12663786 (2), 12379843 (2), 15163754 (1) (see all 11)
adriamycin	4.44	2	15044860 (1), 15197357 (1)
vincristine	1.12	3	15044860 (2), 15197357 (1)
tyrosine	1.05	7	12802020 (1), 18716056 (1), 12900394 (1), 19808888 (1) (see all 7)
leucine	0	2	12663786 (1)
estrogen	0	2	9588212 (1), 10440698 (1)
testosterone	0	6	14761944 (5), 10440698 (1)

Search CenterWatch for drugs/clinical trials and news about TSG101 / TS101

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSG101 gene:

NM_006292.3

Unigene Cluster for TSG101:

Tumor susceptibility gene 101

Hs.523512 [show with all ESTs]

Unigene Representative Sequence: BM542397

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000536719 ENST00000580814 ENST00000584526 ENST00000251968(uc001mor.3 uc001mos.2 uc009yhs.2)

ENST00000540555 ENST00000545247 ENST00000543054 ENST00000543087 ENST00000544804

ENST00000438874 ENST00000542488 ENST00000535077 ENST00000537847 ENST00000357193

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		SwitchGear 3'UTR luciferase reporter plasmid: TSG101 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSG101

Additional cDNA sequence:

AK130787.1 AY207473.1 AY207474.1 BC002487.1 U82130.1

14 DOTS entries:

DT.453312 DT.100878565 DT.95255424 DT.40111610 DT.100878556 DT.91759345 DT.95255430 DT.75123290

DT.100704034 DT.100061070 DT.120699775 DT.40123689 DT.65288214 DT.91759346

24/365 AceView cDNA sequences (see all 365):

BG943357 CR617651 BP358610 BF002850 BP378195 BG424979 CB140667 CB528488

CR619803 BM771131 BG944929 BU507489 CR621064 BI255829 CR594582 AL522502

BM751990 AL555960 AI470855 BX402728 AY207473 CB529623 BG941031 BE465282

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSG101 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACGTCTTCT

About this image

TSG101 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TSG101 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSG101

SOURCE GeneReport for Unigene cluster: Hs.523512

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816

Tissue specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas

SABiosciences Expression via Pathway-Focused PCR Arrays including TSG101:

HIV Host Response in human mouse rat

Cell Cycle in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSG101

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSG101

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSG101 gene from 10/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tsg101^{1 , 5}	tumor susceptibility gene 101^{1, 5}	89.57(n)¹ 94.87(a)¹		7 (30.62 cM)⁵ 22088¹ NM_021884.3¹ NP_068684.1¹ 46888949⁵
chicken (Gallus gallus)	Aves	UEVLD¹	UEV and lactate/malate dehyrogenase domains	80.93(n) 90.98(a)		423082 XM_003641342.1 XP_003641390.1
lizard (Anolis carolinensis)	Reptilia	TSG101⁶	--	90(a)	1 ↔ 1	1(67814852-67847482)
African clawed frog (Xenopus laevis)	Amphibia	Xl.14395²	Xenopus laevis transcribed sequence with moderate similarity more	79.44(n)		CA972577.1
zebrafish (Danio rerio)	Actinopterygii	tsg101¹	tumor susceptibility gene 101	74.72(n) 85.71(a)		415179 NM_001002089.1 NP_001002089.1
fruit fly (Drosophila melanogaster)	Insecta	TSG101^{1 , 3}	tumor suppressor protein 101¹	48(a)³ 54.91(n)¹ 54.74(a)¹		73D1³ 39881¹ NM_079396.3¹ NP_524120.1¹
worm (Caenorhabditis elegans)	Secernentea	tsg-101¹	Protein TSG-101	51.59(n) 44.41(a)		182474 NM_067963.2 NP_500364.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	STP22(YCL008C)⁴ STP22¹	Component of the ESCRT-I complex, which is involved more⁴ Stp22p¹	40.84(n)¹ 28.83(a)¹		3(106853-105696)⁴ 850349^{1, 4} NP_009919.3^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	ELC¹	protein ELC	45.18(n) 35.24(a)		820419 NM_112075.2 NP_566423.1
rice (Oryza sativa)	Liliopsida	Os02g0833300¹	hypothetical protein	41.62(n) 32.21(a)		4331267 NM_001055169.1 NP_001048634.1

ENSEMBL Gene Tree for TSG101 (if available)
TreeFam Gene Tree for TSG101 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201168438^1,2	C	--	18187243(-)	`GCAGGG/TCCAAA`	1	--	ds500¹		0	--	--	--	--
rs15387^1,2	C	--	18187736(-)	`TCCTTT/ATATCA`	1	--	ut3¹ trp³		6		MN	584
rs11542667^1,2	H	--	18187800(-)	`GTGACC/TTCTAC`	2	L F	mis¹ ese³		4		NS EA	402
rs1804795^1,2	C	--	18187845(-)	`AGCTGA/GGGGCA`	2	R G	mis¹		5		MN	404
rs114250357^1,2	C,F,	--	18188150(+)	`TGTACA/GGAAAA`	1	--	int¹		1		WA	118
rs77666705^1,2	C,	--	18188531(+)	`AGGTGG/ACACAA`	1	--	int¹		2		WA	120
rs35188373^1,2	F	--	18188540(-)	`GATCAC/TTGATT`	1	--	int¹		5		MN	400
rs114436060^1,2	C,F,	--	18188753(+)	`TAGTGT/CTTTTT`	1	--	int¹		1		WA	118
rs114966126^1,2	C,F,	--	18189374(+)	`TCAGCG/AACAAA`	1	--	int¹		1		WA	118
rs74331446^1,2	F,	--	18189923(+)	`TGAAGG/ATTGCA`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for TSG101 (18489883 - 18548779 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TSG101
1 CNV: 58503

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TSG101 for disorders           About GeneDecksing

OMIM gene information: 601387    OMIM disorders: --

20/46 diseases for TSG101 (see all 46):    About MalaCards

charcot-marie-tooth disease breast cancer human t-cell leukemia virus type 1 wiskott-aldrich syndrome

soft tissue sarcoma japanese encephalitis tooth disease leukemia/lymphoma

leukemia/lymphoma, t-cell hepatitis e papillary thyroid carcinoma breast-ovarian cancer

herpes simplex burkitt's lymphoma endometrial carcinoma ovarian cancer

encephalitis carcinoma familial breast cancer cervicitis

10/21 Novoseek disease relationships for TSG101 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	55.7	18	12388682 (2), 16809281 (2), 17182674 (2), 12915533 (1) (see all 15)
tumors	41.2	100	11838966 (5), 10618725 (4), 9588212 (4), 14991575 (3) (see all 49)
breast cancer	38.1	43	10930114 (4), 9019400 (4), 9849457 (3), 9652749 (3) (see all 24)
leukemia t-cell	37.3	1	14581525 (1)
cervical carcinoma	27.7	4	10505033 (2), 10027311 (1)
charcot-marie-tooth disease	25.3	2	15776429 (1), 16118794 (1)
leukemia	22.6	8	10664246 (3), 14526201 (1), 9722303 (1), 12743307 (1) (see all 5)
somatic mutations	21.4	2	9253709 (1), 9366528 (1)
ovarian cancer	21.1	18	17606716 (5), 9773405 (4), 17110434 (3), 9530348 (1) (see all 5)
cancer	18.9	27	17369844 (3), 9652749 (2), 10618725 (1), 10202180 (1) (see all 16)

Human Genome Epidemiology (HuGE) Navigator: TSG101 (5 documents)
Tumor Gene Database (TGDB): TSG101

Export disorders for TSG101 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TSG101 gene, integrated from 9 sources (see all 263):
(articles sorted by number of sources associating them with TSG101)

Utopia: connect your pdf to the dynamic
world of online information

The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. (PubMed id 9019400)^{1, 2, 3, 9} Li L.... Cohen S.N. (1997)
Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours. (PubMed id 9366528)^{1, 2, 9} Gayther S.A.... Caldas C. (1997)
Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants. (PubMed id 9840940)^{1, 2, 9} Wagner K.-U....Hennighausen L. (1998)
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. (PubMed id 12900394)^{1, 2, 9} Pornillos O.... Sundquist W.I. (2003)
Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101. (PubMed id 19520058)^{1, 2, 9} Okumura M.... Maki M. (2009)
PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. (PubMed id 14581525)^{1, 2, 9} Bouamr F.... Goff S.P. (2003)
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. (PubMed id 12802020)^{1, 2, 9} Lu Q....Cohen S.N. (2003)
Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)^{1, 2, 9} Eastman S.W.... Bieniasz P.D. (2005)
Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. (PubMed id 12379843)^{1, 2, 9} Pornillos O.... Sundquist W.I. (2002)
Structure and functional interactions of the Tsg101 UEV domain. (PubMed id 12006492)^{1, 2, 9} Pornillos O.W....Sundquist W.I. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7251	HGNC: 15971	AceView: TSG101	Ensembl:ENSG00000074319	euGenes: HUgn7251
ECgene: TSG101	Kegg: 7251	H-InvDB: TSG101

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TSG101	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TSG101	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TSG101 gene
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Patent Information for TSG101 gene:
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tumor susceptibility gene 101

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