V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

TSG101 Gene

protein-coding GIFtS: 66

GC11M018458

tumor susceptibility gene 101
(Previous name: tumor susceptibility gene 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TSG10)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TSG10 ^²
VPS23 ^¹, ²

Descriptions
ESCRT-I complex subunit TSG101 ^³
tumor susceptibility gene 10 ^¹
tumor susceptibility gene 101 ^²
tumor susceptibility protein ^²

External Ids
HGNC: 15971¹
Entrez Gene: 7251²
UniProtKB: Q99816³
Ensembl: ENSG00000074319⁷

Search outside databases for aliases for TSG101 gene

Previous GC identifers: GC11M019623 GC11M019444 GC11M018541 GC11M018466

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TSG101:

The protein encoded by this gene belongs to a group of apparently inactive homologs of

ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with

stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in

cell growth and differentiation and act as a negative growth regulator. In vitro steady-state

expression of this tumor susceptibility gene appears to be important for maintenance of genomic

stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high

frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis

and/or progression. [provided by RefSeq]

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816

Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to

ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos

into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I

complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in

cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of

many viruses through an interaction with viral proteins that contain a late-budding motif

P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses

Gene Wiki entry for TSG101

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TSG101 gene

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15

TSG101 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M018458: (about GC identifiers)

Start:	18,458,434 bp from pter
End:	18,505,065 bp from pter
Size:	46,632 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816 (See protein sequence)

Recommended Name: Tumor susceptibility gene 101 protein

Size: 390 amino acids; 43944 Da

Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I)

which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and a FAM125/MVB12 protein

(FAM125A or -B) in a 1:1:1:1 stoechiometry. Interacts with VPS37A, VPS37B and VPS37C. Interacts

with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Interacts with HGS; the

interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3.

Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36.

Self-associates. Interacts with FAM125A/MVB12A; the association appears to be mediated by the

TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with

CEP55; the interaction is required for cytokinesis but not for viral budding. Interacts with HIV-1

p6. Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus

VP40. Interacts with EIAV p9; the interaction has been shown in vitro

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome

membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active

and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus.

Colocalized with CEP55 in the midbody during cytokinesis

PDB structures from and Proteopedia :

1KPP (3D)

1KPQ (3D)

1M4P (3D)

1M4Q (3D)

1S1Q (3D)

2F0R (3D)

Secondary accessions: Q9BUM5

Alternative splicing: 2 isoforms: Q99816-1 Q99816-2 (Additional isoforms seem to exist. Several shorter isoforms are detected in primary breast cancers and other tumors)

Post-translational modifications:

Monoubiquitinated at multiple sites by LRSAM1. Ubiquitination inactivates it, possibly by

regulating its shuttling between an active membrane-bound protein and an inactive soluble form¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006283.1

ENSEMBL proteins:

ENSP00000349721 ENSP00000251968

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TSG101)
	Human Recombinant Proteins from Abnova (TSG101)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0005771	multivesicular body	TAS	15611048
GO:0005886	plasma membrane	IDA	18029348

About this table

Antibodies for TSG101:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for TSG101
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TSG101), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TSG101)
	Novus Biologicals Antibodies for TSG101

Assays for TSG101:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99816

ProtoNet protein and cluster: Q99816

2 Blocks protein families:

IPB000608 Ubiquitin-conjugating enzymes

IPB008883 Tumour susceptibility gene 101

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816

Domain: The UEV domain is required for the interaction of the complex with ubiquitin. It also

mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag

protein

Domain: The coiled coil domain may interact with stathmin

Domain: The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently

Similarity: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily

Similarity: Contains 1 SB (steadiness box) domain

Similarity: Contains 1 UEV (ubiquitin E2 variant) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TSG101)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TSG101)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006292

Applied Biosystems Silencer® siRNAs for TSG101

Sigma-Aldrich siRNA and siRNA Panels for TSG101

Sigma-Aldrich shRNA Panels and shRNA for TSG101

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TSG101
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006292
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006292
untagged cDNA clone in CMV expression vector: NM_006292

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006292

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816

Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to

ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos

into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I

complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in

cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of

many viruses through an interaction with viral proteins that contain a late-budding motif

P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses

Genatlas biochemistry entry for TSG101:

murine tumor susceptibility gene 101 (Tsg101) homolog,43kDa,transcriptional suppressor for ESRR and

other nuclear hormone receptors,mutated in primary breast carcinoma,aberrantly spliced in small

cell lung carcinoma and in cervical,endometrial,hormone refractory prostate cancer,involved in

cell cycle regulation

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tsg101):

cellular	embryogenesis	endocrine/exocrine gland	growth/size	lethality-prenatal/perinatal
normal	reproductive system	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	10888872
GO:0003714	transcription corepressor activity	TAS	10888872
GO:0005515	protein binding	IPI	12029088 15033475 17350572
GO:0019787	small conjugating protein ligase activity	IEA	--
GO:0043130	ubiquitin binding	TAS	15611048

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for TSG101 (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis
Mechanisms of Viral Exit from Host Cells
Glucocorticoid Receptor Signaling

GeneDecks TSG101 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TSG101

5/54 Interacting proteins for TSG101 (ENSP00000251968³ Q99816^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 54 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEP55	Q53EZ4²	STRING (score=.981) MINT-6173601 MINT-6169549 MINT-6173584 MINT-6173720 MINT-6175155 MINT-6173676 MINT-6173387 MINT-6173737 MINT-6173542
DMAP1	Q9NPF5¹	STRING (score=.968) EBI-346882, EBI-399105
HGS	O14964²	STRING (score=.994) MINT-50310 MINT-50311 MINT-50312 MINT-50313 MINT-68474
VPS28	Q9UK41²	STRING (score=.999) MINT-6173737 MINT-6173772
VPS37B	Q9H9H4²	STRING (score=.998) MINT-6173737 MINT-6173772

About this table

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0007050	cell cycle arrest	IEA	--
GO:0008285	negative regulation of cell proliferation	IEA	--
GO:0015031	protein transport	IEA	--
GO:0030216	keratinocyte differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TSG101
3 Novoseek chemical compound relationships for TSG101 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ptap	95.05	15	12915533 (3), 12663786 (2), 12379843 (2), 15163754 (1) (see all 10)
leucine	0.00	2	12663786 (1)
tyrosine	0.00	6	12802020 (1), 18716056 (1), 12900394 (1), 14724156 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TSG101)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TSG101)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006292

Sigma-Aldrich siRNA and siRNA Panels for TSG101

Sigma-Aldrich shRNA Panels and shRNA for TSG101

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006292

REFSEQ mRNAs for TSG101 gene:

NM_006292.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006292

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006292
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006292
                                 untagged cDNA clone in CMV expression vector: NM_006292

Additional cDNA sequence:

AK130787.1 AY207473.1 AY207474.1 BC002487.1 CR590335.1 CR590804.1 CR594582.1 CR596481.1

CR598203.1 CR604898.1 CR606222.1 CR617651.1 CR619803.1 CR621064.1 CR623726.1 U82130.1

14 DOTS entries:

DT.453312 DT.100878565 DT.95255424 DT.40111610 DT.100878556 DT.91759345 DT.95255430 DT.75123290

DT.100704034 DT.100061070 DT.120699775 DT.40123689 DT.65288214 DT.91759346

24/365 AceView cDNA sequences (see all 365 ):

BI906734 CB123589 BP335705 BE465282 AL522502 BM771437 BG424979 CA843510

BG943357 AY207474 CA488886 AL553112 CR621064 BM838498 BM847812 CD172428

AW189684 AA480013 CB111114 AW304361 CR617651 CB528488 AW189724 CD672200

highest scoring ESTs for TSG101:

U82130 AI929637 AK130787 AL525128 AL548035 AL555960 AL574901 AL597660 AU099471 AU138453

Unigene Cluster for TSG101:

Tumor susceptibility gene 101

Hs.523512 [show with all ESTs]

Unigene Representative Sequence: BM542397

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000357193 ENST00000251968

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TSG101 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TSG101

¹ / ² / ³

3 probe-sets matching TSG101 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
147_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U82130	1.00	1.00	1.00	1
201758_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006292	0.60	1.00	0.82	1
201758_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TSG101 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACGTCTTCT

SOURCE GeneReport for Unigene cluster: Hs.523512
Expression variation in blood from EXPOLDB for TSG101
UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TSG101 gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TSG101¹	--	tumor susceptibility gene 101	94.44(n) 97.69(a)	485406 XM_860360.1 XP_865453.1
chimpanzee (Pan troglodytes)	TSG101¹	--	tumor susceptibility gene 101	99.91(n) 100(a)	451065 XM_001173373.1 XP_001173373.1
cow (Bos taurus)	TSG101¹	--	tumor susceptibility gene 101	94.1(n) 97.69(a)	507659 XM_001251346.1 XP_001251347.1
rat (Rattus norvegicus)	Tsg101¹	--	tumor susceptibility gene 101	89.15(n) 93.85(a)	292925 NM_181628.2 NP_853659.2
mouse (Mus musculus)	Tsg101^{1, 5}	7⁵	tumor susceptibility gene 101^{1, 5}	89.57(n)¹ 94.87(a)¹	22088¹ NM_021884.3¹ NP_068684.1¹ AF060868⁵ AI255943⁵ (see all 21)

About this table Species with no ortholog for TSG101

ENSEMBL Gene Tree for TSG101

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/265 NCBI SNPs in TSG101 are shown (see all 265 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 99)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2291752^1,2	A,C,F,H,O	18458304(+)	`TAATTC/TACTTT`	1	--	ng5¹		13	EA NA EU WA MN CSAM	2422
	rs1857909^1,2	C,F,H,O	18505457(+)	`CGCAAG/ATTTCT`	1	--	ng3¹		18	NS EU EA WA NA MN CSAM	1288
	rs3802966^1,2	C,F,H	18505539(-)	`AAGGTC/GTTTAA`	1	--	ng3¹		14	EA MN CSAM EU WA	2532
	rs3802965^1,2	C,F,H	18505895(-)	`AATACC/GTTGAA`	1	--	ng3¹		12	EA MN CSAM EU WA	2264
	rs2291754^1,2	C,F,H	18458594(+)	`ACTTAT/CTCTGG`	1	--	ut3¹		13	EA NA MN CSAM EU WA	2452
	rs2291753^1,2	C,F,H	18458410(+)	`TTCCTA/CAAGTC`	1	--	ng5¹		14	EA MN CSAM EU WA	2710
--	rs11024699^1,2	A,C,F	18506142(+)	`ttgagT/Acactc`	1	--	ng3¹ tfbs³		5	MN CSAM EA	388
	rs2291751^1,2	C,F,H	18458230(+)	`CACAGA/GTAAGT`	1	--	ng5¹		17	EA NA EU WA MN CSAM	2804
	rs2292179^1,2	C,F,H	18505122(+)	`GGTGGA/GCRCCG`	1	--	ng3¹		11	EA EU MN CSAM WA	2406
	rs1857908^1,2	C,H	18505150(+)	`CCTGGC/TGGGGT`	1	--	ng3¹ tfbs³		9	EU EA WA MN CSAM	782

About this table

HapMap Linkage Disequilibrium images for TSG101 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601387

10/21 Novoseek disease relationships for TSG101 gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	56.37	17	12388682 (2), 16809281 (2), 17182674 (2), 12915533 (1) (see all 14)
tumors	40.68	90	11838966 (5), 10618725 (4), 9588212 (4), 14991575 (3) (see all 44)
breast cancer	40.25	43	10930114 (4), 9019400 (4), 9849457 (3), 9652749 (3) (see all 24)
leukemia t-cell	38.69	1	14581525 (1)
cervical carcinoma	29.55	4	10505033 (2), 10027311 (1)
charcot-marie-tooth disease	27.54	2	15776429 (1), 16118794 (1)
leukemia	24.41	8	10664246 (3), 14526201 (1), 9722303 (1), 12743307 (1) (see all 5)
ovarian cancer	23.47	18	17606716 (5), 9773405 (4), 17110434 (3), 9530348 (1) (see all 5)
somatic mutations	23.30	2	9253709 (1), 9366528 (1)
cancer	18.83	23	17369844 (3), 9652749 (2), 10618725 (1), 10202180 (1) (see all 14)

About this table

Human Genome Epidemiology Navigator: TSG101 (1 document)
Tumor Gene Database: TSG101
Breast Cancer Gene Database: TSG101

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/176 PubMed articles for TSG101 gene (see all 176 ):

The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. (PubMed id 9019400)^{1, 2, 3, 4} Li L.... Cohen S.N. (1997)
Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours. (PubMed id 9366528)^{1, 3, 4} Gayther S.A.... Caldas C. (1997)
Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants. (PubMed id 9840940)^{1, 3, 4} Wagner K.-U....Hennighausen L. (1998)
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. (PubMed id 12900394)^{1, 3, 4} Pornillos O....Sundquist W.I. (2003)
PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 corrected. (PubMed id 14581525)^{1, 3, 4} Bouamr F.... Goff S.P. (2003)
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. (PubMed id 12802020)^{1, 3, 4} Lu Q....Cohen S.N. (2003)
Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)^{1, 3, 4} Eastman S.W.... Bieniasz P.D. (2005)
Structure and functional interactions of the Tsg101 UEV domain. (PubMed id 12006492)^{1, 3, 4} Pornillos O.W....Sundquist W.I. (2002)
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)^{1, 3, 4} Morita E....Sundquist W.I. (2007)
The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. (PubMed id 15218037)^{1, 3, 4} Stuchell M.D....Sundquist W.I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7251	HGNC: 15971	AceView: TSG101	Ensembl:ENSG00000074319	euGenes: HUgn7251
ECgene: TSG101	H-InvDB: TSG101

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TSG101	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TSG101
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TSG101:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TSG101-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TSG101		Antibodies for TSG101
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TSG101		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TSG101)
	Antibodies (TSG101)
	Chimera RNAi (TSG101)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TSG101)
	Antibodies (TSG101)

Search OriGene for TSG101

Search Tocris compounds for TSG101

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TSG101

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TSG101 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

TSG101 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for TSG101

Summaries
for TSG101

Genomic Location
for TSG101

Proteins
for TSG101

Protein Domains/
Families
for TSG101

Gene Function
for TSG101

Pathways & Interactions
for TSG101

Drugs & Compounds
for TSG101

Transcripts
for TSG101

Expression
for TSG101

Orthologs
for TSG101

Paralogs
for TSG101

SNPs/Variants
for TSG101

Disorders & Mutations
for TSG101

Medical News
for TSG101

Publications
for TSG101

Search for TSG101

Genome Databases showing TSG101

Other Databases showing TSG101

Specialized Databases showing TSG101

Licensable Technologies
for TSG101

Services
for TSG101

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TSG101 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor TSG101

Summariesfor TSG101

Genomic Locationfor TSG101

Proteinsfor TSG101

Protein Domains/Familiesfor TSG101

Gene Functionfor TSG101

Pathways & Interactionsfor TSG101

Drugs & Compoundsfor TSG101

Transcriptsfor TSG101

Expression for TSG101

Orthologsfor TSG101

Paralogsfor TSG101

SNPs/Variantsfor TSG101

Disorders & Mutationsfor TSG101

Medical Newsfor TSG101

Publicationsfor TSG101

Search for TSG101

Genome Databases showing TSG101

Other Databases showing TSG101

Specialized Databases showing TSG101

Licensable Technologiesfor TSG101

Servicesfor TSG101

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TSG101

Summaries
for TSG101

Genomic Location
for TSG101

Proteins
for TSG101

Protein Domains/
Families
for TSG101

Gene Function
for TSG101

Pathways & Interactions
for TSG101

Drugs & Compounds
for TSG101

Transcripts
for TSG101

Expression
for TSG101

Orthologs
for TSG101

Paralogs
for TSG101

SNPs/Variants
for TSG101

Disorders & Mutations
for TSG101

Medical News
for TSG101

Publications
for TSG101

Licensable Technologies
for TSG101

Services
for TSG101