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TSG101 Gene

protein-coding   GIFtS: 68
GCID: GC11M018501

Tumor Susceptibility 101

(Previous names: tumor susceptibility gene 10, tumor susceptibility gene...)
(Previous symbol: TSG10)
  See TSG101-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Susceptibility 1011 2     ESCRT-I Complex Subunit TSG1012 3
TSG101 2     VPS232
Tumor Susceptibility Gene 101 2     Tumor Susceptibility Gene 101 Protein2
Tumor Susceptibility Gene 1011 2     Tumor Susceptibility Protein2

External Ids:    HGNC: 159711   Entrez Gene: 72512   Ensembl: ENSG000000743197   OMIM: 6013875   UniProtKB: Q998163   

Export aliases for TSG101 gene to outside databases

Previous GC identifers: GC11M019623 GC11M019444 GC11M018541 GC11M018466 GC11M018458 GC11M018187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSG101 Gene:
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating
enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein
implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative
growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for
maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur
in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or
progression. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSG101 Gene:
TSG101 (tumor susceptibility 101) is a protein-coding gene. Diseases associated with TSG101 include breast cancer, somatic, and ovarian cancer. GO annotations related to this gene include ubiquitin binding and transcription corepressor activity.

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
(MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis;
the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth
regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a
late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses

Gene Wiki entry for TSG101 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSG101 gene promoter:
         GR   GR-beta   FOXD1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSG101 promoter sequence
   Search Chromatin IP Primers for TSG101

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSG101


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15

TSG101 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSG101 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018501:  view genomic region     (about GC identifiers)

Start:
18,489,883 bp from pter      End:
18,548,779 bp from pter
Size:
58,897 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816 (See protein sequence)
Recommended Name: Tumor susceptibility gene 101 protein  
Size: 390 amino acids; 43944 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of
TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with
VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Component of
an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A
and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with HGS; the interaction mediates the association with the
ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with
VPS28, SNF8 and VPS36. Self-associates. Interacts with MVB12A; the association appears to be mediated by the
TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the
interaction is required for cytokinesis but not for viral budding. Interacts with PDCD6. Interacts with HIV-1 p6.
Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus VP40. Interacts with
EIAV p9; the interaction has been shown in vitro. Interacts with MGRN1
Selected PDB 3D structures from and Proteopedia for TSG101 (see all 14):
1KPP (3D)        1KPQ (3D)        1M4P (3D)        1M4Q (3D)        1S1Q (3D)        2F0R (3D)    
Secondary accessions: Q9BUM5
Alternative splicing: 2 isoforms:  Q99816-1   Q99816-2   (Detected in normal as well as cancer tissues)

Explore the universe of human proteins at neXtProt for TSG101: NX_Q99816

Explore proteomics data for TSG101 at MOPED

Post-translational modifications: 

  • Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating
    its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1
    requires the presence of UBE2D11
  • Ubiquitination2 at Lys237, Lys361
  • Modification sites at PhosphoSitePlus

  • See TSG101 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006283.1  
    ENSEMBL proteins: 
     ENSP00000438471   ENSP00000464386   ENSP00000463213   ENSP00000251968   ENSP00000349721  
    Reactome Protein details: Q99816

    TSG101 Human Recombinant Protein Products:

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    Novus Biologicals TSG101 Proteins
    Novus Biologicals TSG101 Lysates
    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for TSG101
    Cloud-Clone Corp. Proteins for TSG101

     
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    antibodies-online proteins for TSG101 (18 products) 

     
    antibodies-online peptides for TSG101

    TSG101 Antibody Products:

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    TSG101 Assay Products:

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    Cloud-Clone Corp. ELISAs for TSG101
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    antibodies-online kits for TSG101 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008883 UEV_N
     IPR017916 Steadiness_box
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q99816

    ProtoNet protein and cluster: Q99816

    2 Blocks protein domains:
    IPB000608 Ubiquitin-conjugating enzymes
    IPB008883 Tumour susceptibility gene 101


    UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816
    Domain: The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the
    interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein
    Domain: The coiled coil domain may interact with stathmin
    Domain: The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily
    Similarity: Contains 1 SB (steadiness box) domain
    Similarity: Contains 1 UEV (ubiquitin E2 variant) domain


    Find genes that share domains with TSG101           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TS101_HUMAN, Q99816
    Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
    cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
    (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis;
    the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth
    regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a
    late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses

         Genatlas biochemistry entry for TSG101:
    murine tumor susceptibility gene 101 (Tsg101) homolog,43kDa,transcriptional suppressor for ESRR and other nuclear
    hormone receptors,mutated in primary breast carcinoma,aberrantly spliced in small cell lung carcinoma and in
    cervical,endometrial,hormone refractory prostate cancer,involved in cell cycle regulation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10888872
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI15033475
    GO:0031625ubiquitin protein ligase binding IPI17229889
    GO:0043130ubiquitin binding TAS15611048
         
    Find genes that share ontologies with TSG101           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TSG101:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tsg101):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size/body  integument 
     mortality/aging  normal  tumorigenesis 

    Find genes that share phenotypes with TSG101           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TSG101: Tsg101tm1.1Kuw Tsg101tm1Mak

       genOway: Develop your customized and physiologically relevant rodent model for TSG101

    miRNA
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    miRTarBase miRNAs that target TSG101:
    hsa-mir-33a-5p (MIRT028189), hsa-mir-130b-3p (MIRT020275), hsa-mir-331-3p (MIRT043363), hsa-mir-20a-5p (MIRT031083), hsa-mir-93-5p (MIRT028151)

    Block miRNA regulation of human, mouse, rat TSG101 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSG101 (see all 18):
    hsa-miR-106a hsa-miR-1285 hsa-miR-519a hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidTSG101 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TSG101

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TSG101 (NM_006292)
    Sino Biological Human cDNA Clone for TSG101
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSG101
    Addgene plasmids for TSG101 

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    eBioscience FlowRNA Probe Sets ( VA1-12072) for TSG101 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TS101_HUMAN, Q99816: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane;
    Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive.
    Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during
    cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    plasma membrane4
    cytosol3
    lysosome2
    vacuole2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000813ESCRT I complex IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005769early endosome IDA17229889
    GO:0005770late endosome IMP15126635

    Find genes that share ontologies with TSG101           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSG101 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    Membrane binding and targetting of GAG proteins0.00
    Late Phase of HIV Life Cycle0.91
    Assembly Of The HIV Virion0.00
    HIV Infection0.62
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58
    4Clathrin dependent protein traffic
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    5Clathrin derived vesicle budding
    Membrane Trafficking0.32


    Find genes that share SuperPaths with TSG101           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TSG101
        Breast Cancer Regulation by Stathmin1

    2 GeneGo (Thomson Reuters) Pathways for TSG101
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF

    2 BioSystems Pathways for TSG101
        Internalization of ErbB1
    Glucocorticoid receptor regulatory network


    3 Reactome Pathways for TSG101
        Budding and maturation of HIV virion
    Membrane binding and targetting of GAG proteins
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for TSG101):
        Endocytosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TSG101: 
              HIV Host Response in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TSG101

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TSG101 (Q998161, 2, 3 ENSP000002519684) via UniProtKB, MINT, STRING, and/or I2D (see all 973)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP55Q53EZ41, 2, 3, ENSP000003605404EBI-346882,EBI-747776 MINT-6173601 MINT-6173584 MINT-6169549 MINT-6173720 MINT-6175155 MINT-6173676 MINT-6173387 MINT-6173737 MINT-6173542 I2D: score=5 STRING: ENSP00000360540
    IQGAP1P469401, 2, 3, ENSP000002681824EBI-346882,EBI-297509 MINT-6169583 MINT-6173635 MINT-6173707 MINT-7945693 MINT-7947479 MINT-6173355 MINT-6173372 I2D: score=2 STRING: ENSP00000268182
    CD2APQ9Y5K61, 2, 3, ENSP000003522644EBI-346882,EBI-298152 MINT-6173687 MINT-6173772 I2D: score=1 STRING: ENSP00000352264
    HGSO149642, 3, ENSP000003312014MINT-50310 MINT-50311 MINT-50312 MINT-50313 MINT-68474 I2D: score=8 STRING: ENSP00000331201
    ENSG00000206206Q9UER71, 3EBI-346882,EBI-77321 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0006464cellular protein modification process IEA--
    GO:0007050cell cycle arrest IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0015031protein transport IEA--

    Find genes that share ontologies with TSG101           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSG101 (TS101)

    7 Novoseek inferred chemical compound relationships for TSG101 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ptap 95.2 16 12915533 (3), 12663786 (2), 12379843 (2), 15163754 (1) (see all 11)
    adriamycin 4.44 2 15044860 (1), 15197357 (1)
    vincristine 1.12 3 15044860 (2), 15197357 (1)
    tyrosine 1.05 7 12802020 (1), 18716056 (1), 12900394 (1), 19808888 (1) (see all 7)
    leucine 0 2 12663786 (1)
    estrogen 0 2 9588212 (1), 10440698 (1)
    testosterone 0 6 14761944 (5), 10440698 (1)



    Find genes that share compounds with TSG101           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSG101 gene: 
    NM_006292.3  

    Unigene Cluster for TSG101:

    Tumor susceptibility gene 101
    Hs.523512  [show with all ESTs]
    Unigene Representative Sequence: BM542397
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536719 ENST00000580814 ENST00000584526 ENST00000251968(uc001mor.3 uc001mos.2 uc009yhs.2)
    ENST00000540555 ENST00000545247 ENST00000543054 ENST00000543087 ENST00000544804
    ENST00000438874 ENST00000542488 ENST00000535077 ENST00000357193
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    hsa-miR-106a hsa-miR-1285 hsa-miR-519a hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17 hsa-miR-20a
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    Additional mRNA sequence: 

    AK130787.1 AY207473.1 AY207474.1 BC002487.1 U82130.1 

    14 DOTS entries:

    DT.453312  DT.100878565  DT.95255424  DT.40111610  DT.100878556  DT.91759345  DT.95255430  DT.75123290 
    DT.100704034  DT.100061070  DT.120699775  DT.40123689  DT.65288214  DT.91759346 

    Selected AceView cDNA sequences (see all 365):

    AL555960 AW304361 BM839668 BG945035 CD672200 CR619803 BM670557 CR617651 
    BQ230430 BI834762 N34624 BG424979 CR604898 BM771131 BP382018 BU180842 
    CR623726 BF054864 BP358610 BM700444 AA480013 AL553112 BG941031 BX402450 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSG101 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGTCTTCT
    TSG101 Expression
    About this image


    TSG101 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    TSG101 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSG101 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523512

    UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816
    Tissue specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TSG101: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TSG101 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsg1011 , 5 tumor susceptibility gene 1011, 5 89.57(n)1
    94.87(a)1
      7 (30.62 cM)5
    220881  NM_021884.31  NP_068684.11 
     468889495 
    chicken
    (Gallus gallus)
    Aves TSG1011 tumor susceptibility gene 101 78.83(n)
    88.95(a)
      423082  NM_001277415.1  NP_001264344.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSG1016
    tumor susceptibility 101
    91(a)
    1 ↔ 1
    1(67814852-67847723)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143952 Xenopus laevis transcribed sequence with moderate similarity more 79.44(n)    CA972577.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsg101a1 tumor susceptibility gene 101a 73.14(n)
    83.99(a)
      415179  NM_001002089.1  NP_001002089.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TSG1011 , 3 tumor suppressor protein 1011 48(a)3
    54.39(n)1
    53.68(a)1
      73D13
    398811  NM_079396.41  NP_524120.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tsg-1011 tsg-101 50.27(n)
    42.97(a)
      182474  NM_067963.2  NP_500364.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STP22(YCL008C)4 Component of the ESCRT-I complex, which is involved more   --   3(106853-105696) 850349  NP_009919.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ELC1 ELC 44.31(n)
    34.12(a)
      820419  NM_112075.2  NP_566423.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08333001 Os02g0833300 42.26(n)
    32.92(a)
      4331267  NM_001055169.1  NP_001048634.1 


    ENSEMBL Gene Tree for TSG101 (if available)
    TreeFam Gene Tree for TSG101 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSG101 gene
    1 SIMAP similar gene for TSG101 using alignment to 7 protein entries:     TS101_HUMAN (see all proteins):
    UEVLD

    Find genes that share paralogs with TSG101           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSG101 (see all 980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011684381,2
    C--18425957(-) GCAGGG/TCCAAA 1 -- ds50010--------
    rs22917511,2
    C,F,H--18426067(+) CACAGA/GTAAGT 1 -- ds500132Minor allele frequency- G:0.18EA NA NS MN CSA 4616
    rs1473983751,2
    --18426134(+) CCATG-/TTAA  
            
    TTAAT
    1 -- ds50010--------
    rs22917521,2
    C,F,O,A,H--18426141(+) TAATTC/TACTTT 1 -- ds500126Minor allele frequency- T:0.26EA NA NS MN 4004
    rs1923871911,2
    --18426235(+) TTTCAC/TGGATC 1 -- ds50010--------
    rs22917531,2
    C,F,H--18426247(+) TTCCTA/CAAGTC 1 -- ds500122Minor allele frequency- C:0.12EA MN NS NA 3984
    rs1433960511,2
    --18426261(+) TAAAGA/GAGAGA 1 -- ds50010--------
    rs1837850981,2
    --18426351(+) AAAGCC/TAGTCT 1 -- ut310--------
    rs22917541,2
    C,F,H--18426431(+) ACTTAT/CTCTGG 1 -- ut3114Minor allele frequency- C:0.03EA NA MN NS 2572
    rs153871,2
    C--18426450(-) TCCTTT/ATATCA 1 -- ut31 trp36Minor allele frequency- A:0.00MN 584

    HapMap Linkage Disequilibrium report for TSG101 (18489883 - 18548779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSG101:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820064CNV Loss19587683
    nsv467719CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSG101
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601387   
    OMIM disorders: 114480  
    3 diseases for TSG101:    
    About MalaCards
    breast cancer, somatic    ovarian cancer    breast cancer


    Find genes that share disorders with TSG101           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TSG101 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 55.7 18 12388682 (2), 16809281 (2), 17182674 (2), 12915533 (1) (see all 15)
    tumors 41.2 100 11838966 (5), 10618725 (4), 9588212 (4), 14991575 (3) (see all 49)
    breast cancer 38.1 43 10930114 (4), 9019400 (4), 9849457 (3), 9652749 (3) (see all 24)
    leukemia t-cell 37.3 1 14581525 (1)
    cervical carcinoma 27.7 4 10505033 (2), 10027311 (1)
    charcot-marie-tooth disease 25.3 2 15776429 (1), 16118794 (1)
    leukemia 22.6 8 10664246 (3), 14526201 (1), 9722303 (1), 12743307 (1) (see all 5)
    somatic mutations 21.4 2 9253709 (1), 9366528 (1)
    ovarian cancer 21.1 18 17606716 (5), 9773405 (4), 17110434 (3), 9530348 (1) (see all 5)
    cancer 18.9 27 17369844 (3), 9652749 (2), 10618725 (1), 10202180 (1) (see all 16)

    Genetic Association Database (GAD): TSG101
    Human Genome Epidemiology (HuGE) Navigator: TSG101 (5 documents)
    Tumor Gene Database (TGDB): TSG101

    Export disorders for TSG101 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSG101 gene, integrated from 10 sources (see all 276):
    (articles sorted by number of sources associating them with TSG101)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. (PubMed id 9019400)1, 2, 3, 9 Li L.... Cohen S.N. (Cell 1997)
    2. Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours. (PubMed id 9366528)1, 2, 9 Gayther S.A.... Caldas C. (Oncogene 1997)
    3. Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants. (PubMed id 9840940)1, 2, 9 Wagner K.-U....Hennighausen L. (Oncogene 1998)
    4. HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. (PubMed id 12900394)1, 2, 9 Pornillos O.... Sundquist W.I. (J. Cell Biol. 2003)
    5. Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101. (PubMed id 19520058)1, 2, 9 Okumura M.... Maki M. (Biochem. Biophys. Res. Commun. 2009)
    6. PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. (PubMed id 14581525)1, 2, 9 Bouamr F.... Goff S.P. (J. Virol. 2003)
    7. TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. (PubMed id 12802020)1, 2, 9 Lu Q.... Cohen S.N. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)1, 2, 9 Eastman S.W.... Bieniasz P.D. (J. Biol. Chem. 2005)
    9. Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. (PubMed id 12379843)1, 2, 9 Pornillos O.... Sundquist W.I. (Nat. Struct. Biol. 2002)
    10. Structure and functional interactions of the Tsg101 UEV domain. (PubMed id 12006492)1, 2, 9 Pornillos O.W....Sundquist W.I. (EMBO J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7251 HGNC: 15971 AceView: TSG101 Ensembl:ENSG00000074319 euGenes: HUgn7251
    ECgene: TSG101 Kegg: 7251 H-InvDB: TSG101

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TSG101 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSG101 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSG101 gene:
    Search GeneIP for patents involving TSG101

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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