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Aliases for TSG101 Gene

Aliases for TSG101 Gene

  • Tumor Susceptibility 101 2 3 5
  • ESCRT-I Complex Subunit TSG101 3 4
  • Tumor Susceptibility Gene 101 2 3
  • Tumor Susceptibility Gene 10 2 3
  • Tumor Susceptibility Protein 3
  • VPS23 3
  • TSG10 3

External Ids for TSG101 Gene

Previous HGNC Symbols for TSG101 Gene

  • TSG10

Previous GeneCards Identifiers for TSG101 Gene

  • GC11M019623
  • GC11M019444
  • GC11M018541
  • GC11M018466
  • GC11M018458
  • GC11M018501
  • GC11M018187

Summaries for TSG101 Gene

Entrez Gene Summary for TSG101 Gene

  • The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSG101 Gene

TSG101 (Tumor Susceptibility 101) is a Protein Coding gene. Diseases associated with TSG101 include Breast Cancer and Hiv-1. Among its related pathways are Infectious disease and HIV Life Cycle. GO annotations related to this gene include protein homodimerization activity and transcription corepressor activity.

UniProtKB/Swiss-Prot for TSG101 Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Gene Wiki entry for TSG101 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSG101 Gene

Genomics for TSG101 Gene

Regulatory Elements for TSG101 Gene

Enhancers for TSG101 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSG101 on UCSC Golden Path with GeneCards custom track

Promoters for TSG101 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSG101 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSG101 Gene

Chromosome:
11
Start:
18,468,336 bp from pter
End:
18,527,232 bp from pter
Size:
58,897 bases
Orientation:
Minus strand

Genomic View for TSG101 Gene

Genes around TSG101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSG101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSG101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSG101 Gene

Proteins for TSG101 Gene

  • Protein details for TSG101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99816-TS101_HUMAN
    Recommended name:
    Tumor susceptibility gene 101 protein
    Protein Accession:
    Q99816
    Secondary Accessions:
    • Q9BUM5

    Protein attributes for TSG101 Gene

    Size:
    390 amino acids
    Molecular mass:
    43944 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding. Interacts with PDCD6. Interacts with HIV-1 p6. Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus VP40. Interacts with EIAV p9; the interaction has been shown in vitro. Interacts with MGRN1.

    Three dimensional structures from OCA and Proteopedia for TSG101 Gene

    Alternative splice isoforms for TSG101 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSG101 Gene

Proteomics data for TSG101 Gene at MOPED

Post-translational modifications for TSG101 Gene

  • Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.
  • Ubiquitination at Lys 237 and Lys 361
  • Modification sites at PhosphoSitePlus

Other Protein References for TSG101 Gene

Antibody Products

No data available for DME Specific Peptides for TSG101 Gene

Domains & Families for TSG101 Gene

Gene Families for TSG101 Gene

Graphical View of Domain Structure for InterPro Entry

Q99816

UniProtKB/Swiss-Prot:

TS101_HUMAN :
  • The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein.
  • Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
Domain:
  • The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein.
  • The coiled coil domain may interact with stathmin.
  • The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently.
  • Contains 1 SB (steadiness box) domain.
  • Contains 1 UEV (ubiquitin E2 variant) domain.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
genes like me logo Genes that share domains with TSG101: view

Function for TSG101 Gene

Molecular function for TSG101 Gene

GENATLAS Biochemistry:
murine tumor susceptibility gene 101 (Tsg101) homolog,43kDa,transcriptional suppressor for ESRR and other nuclear hormone receptors,mutated in primary breast carcinoma,aberrantly spliced in small cell lung carcinoma and in cervical,endometrial,hormone refractory prostate cancer,involved in cell cycle regulation
UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
genes like me logo Genes that share phenotypes with TSG101: view

Human Phenotype Ontology for TSG101 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TSG101 Gene

MGI Knock Outs for TSG101:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TSG101 Gene

Localization for TSG101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSG101 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSG101 Gene COMPARTMENTS Subcellular localization image for TSG101 gene
Compartment Confidence
endosome 5
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
lysosome 2
vacuole 2
cytoskeleton 1
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TSG101 Gene

Pathways & Interactions for TSG101 Gene

genes like me logo Genes that share pathways with TSG101: view

Gene Ontology (GO) - Biological Process for TSG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0006914 autophagy TAS 20588296
GO:0016032 viral process TAS --
GO:0016197 endosomal transport TAS --
GO:0019058 viral life cycle TAS --
genes like me logo Genes that share ontologies with TSG101: view

No data available for SIGNOR curated interactions for TSG101 Gene

Drugs & Compounds for TSG101 Gene

(5) Drugs for TSG101 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TSG101 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSG101: view

Transcripts for TSG101 Gene

Unigene Clusters for TSG101 Gene

Tumor susceptibility gene 101:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSG101 Gene

No ASD Table

Relevant External Links for TSG101 Gene

GeneLoc Exon Structure for
TSG101
ECgene alternative splicing isoforms for
TSG101

Expression for TSG101 Gene

mRNA expression in normal human tissues for TSG101 Gene

Protein differential expression in normal tissues from HIPED for TSG101 Gene

This gene is overexpressed in Urine (9.5) and Bone (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSG101 Gene



SOURCE GeneReport for Unigene cluster for TSG101 Gene Hs.523512

mRNA Expression by UniProt/SwissProt for TSG101 Gene

Q99816-TS101_HUMAN
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
genes like me logo Genes that share expression patterns with TSG101: view

Protein tissue co-expression partners for TSG101 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TSG101 Gene

Orthologs for TSG101 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSG101 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSG101 35
  • 94.1 (n)
  • 97.69 (a)
TSG101 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSG101 35
  • 94.62 (n)
  • 97.95 (a)
TSG101 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsg101 35
  • 89.57 (n)
  • 94.87 (a)
Tsg101 16
Tsg101 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSG101 35
  • 99.91 (n)
  • 100 (a)
TSG101 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsg101 35
  • 89.15 (n)
  • 93.85 (a)
oppossum
(Monodelphis domestica)
Mammalia TSG101 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSG101 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSG101 35
  • 78.83 (n)
  • 88.95 (a)
TSG101 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSG101 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76193 35
tsg101 35
  • 72.7 (n)
  • 82.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14395 35
zebrafish
(Danio rerio)
Actinopterygii tsg101a 35
  • 73.14 (n)
  • 83.99 (a)
TSG101 (1 of 5) 36
  • 75 (a)
OneToMany
TSG101 (3 of 5) 36
  • 40 (a)
OneToMany
TSG101 (4 of 5) 36
  • 95 (a)
OneToMany
TSG101 (5 of 5) 36
  • 39 (a)
OneToMany
tsg101a 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TSG101 37
  • 48 (a)
TSG101 35
  • 54.39 (n)
  • 53.68 (a)
TSG101 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005934 35
  • 56.93 (n)
  • 54.27 (a)
worm
(Caenorhabditis elegans)
Secernentea tsg-101 35
  • 50.27 (n)
  • 42.97 (a)
tsg-101 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STP22 36
  • 23 (a)
OneToOne
STP22 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ELC 35
  • 44.31 (n)
  • 34.12 (a)
rice
(Oryza sativa)
Liliopsida Os02g0833300 35
  • 42.26 (n)
  • 32.92 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2157 35
Species with no ortholog for TSG101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSG101 Gene

ENSEMBL:
Gene Tree for TSG101 (if available)
TreeFam:
Gene Tree for TSG101 (if available)

Paralogs for TSG101 Gene

(1) SIMAP similar genes for TSG101 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TSG101: view

No data available for Paralogs for TSG101 Gene

Variants for TSG101 Gene

Sequence variations from dbSNP and Humsavar for TSG101 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34385327 - 18,506,904(-) GGCAT(A/G)CCAGG reference, missense
rs868069 -- 18,495,474(+) TTTTT(A/G)CCAGG intron-variant
rs1395319 -- 18,526,636(+) CGGGG(G/T)TCTGA intron-variant
rs1395320 -- 18,526,648(+) GAGGT(C/G)GCTAA intron-variant
rs1804795 -- 18,480,599(-) AGCTG(A/G)GGGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TSG101 Gene

Variant ID Type Subtype PubMed ID
nsv467719 CNV Gain 19166990
nsv820064 CNV Loss 19587683

Variation tolerance for TSG101 Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSG101 Gene

Disorders for TSG101 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TSG101 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
hiv-1
  • aids, slow progression to
charcot-marie-tooth disease
  • dejerine-sottas disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSG101

Genetic Association Database (GAD)
TSG101
Human Genome Epidemiology (HuGE) Navigator
TSG101
Tumor Gene Database (TGDB):
TSG101
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSG101
genes like me logo Genes that share disorders with TSG101: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSG101 Gene

Publications for TSG101 Gene

  1. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. (PMID: 9019400) Li L. … Cohen S.N. (Cell 1997) 2 3 4 23 67
  2. Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists. (PMID: 19914066) Liu F. … Burke T.R. (Bioorg. Med. Chem. Lett. 2010) 3 23
  3. TSG101: a novel anti-HIV-1 drug target. (PMID: 20088757) Chen H. … De Clercq E. (Curr. Med. Chem. 2010) 3 23
  4. TEX14 interacts with CEP55 to block cell abscission. (PMID: 20176808) Iwamori T. … Matzuk M.M. (Mol. Cell. Biol. 2010) 3 23
  5. Analysis of expression and structure of the TSG101 gene in cervical cancer cells. (PMID: 20372822) Broniarczyk J. … Gozdzicka-JA^zefiak A. (Int. J. Mol. Med. 2010) 3 23

Products for TSG101 Gene

Sources for TSG101 Gene

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