Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSG101 Gene

protein-coding   GIFtS: 66
GCID: GC11M018501

Tumor Susceptibility 101

(Previous names: tumor susceptibility gene 10, tumor susceptibility gene...)
(Previous symbol: TSG10)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Susceptibility 1011 2     ESCRT-I Complex Subunit TSG1012 3
TSG101 2     VPS232
Tumor Susceptibility Gene 101 2     Tumor Susceptibility Gene 101 Protein2
Tumor Susceptibility Gene 1011 2     Tumor Susceptibility Protein2

External Ids:    HGNC: 159711   Entrez Gene: 72512   Ensembl: ENSG000000743197   OMIM: 6013875   UniProtKB: Q998163   

Export aliases for TSG101 gene to outside databases

Previous GC identifers: GC11M019623 GC11M019444 GC11M018541 GC11M018466 GC11M018458 GC11M018187


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSG101 Gene:
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating
enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein
implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative
growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for
maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur
in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or
progression. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSG101 Gene: 
TSG101 (tumor susceptibility 101) is a protein-coding gene. Diseases associated with TSG101 include hepatitis e, and japanese encephalitis, and among its related super-pathways are HIV Life Cycle and Assembly Of The HIV Virion. GO annotations related to this gene include ubiquitin binding and transcription corepressor activity.

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
(MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis;
the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth
regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a
late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses

Gene Wiki entry for TSG101 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSG101 gene promoter:
         GR   GR-beta   FOXD1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSG101 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSG101

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSG101


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15

TSG101 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSG101 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M018501:  view genomic region     (about GC identifiers)

Start:
18,489,883 bp from pter      End:
18,548,779 bp from pter
Size:
58,897 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816 (See protein sequence)
Recommended Name: Tumor susceptibility gene 101 protein  
Size: 390 amino acids; 43944 Da
Subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of
TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with
VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Component of
an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A
and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with HGS; the interaction mediates the association with the
ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with
VPS28, SNF8 and VPS36. Self-associates. Interacts with MVB12A; the association appears to be mediated by the
TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the
interaction is required for cytokinesis but not for viral budding. Interacts with PDCD6. Interacts with HIV-1 p6.
Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus VP40. Interacts with
EIAV p9; the interaction has been shown in vitro. Interacts with MGRN1
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane;
Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive.
Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during
cytokinesis
6/14 PDB 3D structures from and Proteopedia for TSG101 (see all 14):
1KPP (3D)        1KPQ (3D)        1M4P (3D)        1M4Q (3D)        1S1Q (3D)        2F0R (3D)    
Secondary accessions: Q9BUM5
Alternative splicing: 2 isoforms:  Q99816-1   Q99816-2   (Detected in normal as well as cancer tissues)

Explore the universe of human proteins at neXtProt for TSG101: NX_Q99816

Explore proteomics data for TSG101 at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating
    its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1
    requires the presence of UBE2D1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99816

  • TSG101 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSG101 Protein Expression
    REFSEQ proteins: NP_006283.1  
    ENSEMBL proteins: 
     ENSP00000438471   ENSP00000464386   ENSP00000463213   ENSP00000251968   ENSP00000349721  
    Reactome Protein details: Q99816
    Human Recombinant Protein Products for TSG101: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TSG101
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TSG101
    GenScript Custom Purified and Recombinant Proteins Services for TSG101
    Novus Biologicals TSG101 Proteins
    Novus Biologicals TSG101 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TSG101
    Cloud-Clone Corp. Proteins for TSG101 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000813ESCRT I complex IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005769early endosome IDA17229889
    GO:0005770late endosome IMP15126635

    TSG101 for ontologies           About GeneDecksing



    TSG101 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TSG101
    OriGene Custom Antibody Services for TSG101
    GenScript Custom Superior Antibodies Services for TSG101
    Novus Biologicals TSG101 Antibodies
    Abcam antibodies for TSG101
    Cloud-Clone Corp. Antibodies for TSG101 
    ThermoFisher Antibody for TSG101
    LSBio Antibodies in human, mouse, rat for TSG101 

    Assay Products for TSG101: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSG101
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSG101
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSG101 
    Cloud-Clone Corp. CLIAs for TSG101


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR008883 UEV_N
     IPR017916 Steadiness_box

    Graphical View of Domain Structure for InterPro Entry Q99816

    ProtoNet protein and cluster: Q99816

    2 Blocks protein domains:
    IPB000608 Ubiquitin-conjugating enzymes
    IPB008883 Tumour susceptibility gene 101


    UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816
    Domain: The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the
    interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein
    Domain: The coiled coil domain may interact with stathmin
    Domain: The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily
    Similarity: Contains 1 SB (steadiness box) domain
    Similarity: Contains 1 UEV (ubiquitin E2 variant) domain


    TSG101 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TS101_HUMAN, Q99816
    Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated
    cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
    (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis;
    the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth
    regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a
    late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses

         Genatlas biochemistry entry for TSG101:
    murine tumor susceptibility gene 101 (Tsg101) homolog,43kDa,transcriptional suppressor for ESRR and other nuclear
    hormone receptors,mutated in primary breast carcinoma,aberrantly spliced in small cell lung carcinoma and in
    cervical,endometrial,hormone refractory prostate cancer,involved in cell cycle regulation

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10888872
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI15033475
    GO:0031625ubiquitin protein ligase binding IPI17229889
    GO:0043130ubiquitin binding TAS15611048
         
    TSG101 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TSG101:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tsg101):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size  integument 
     mortality/aging  normal  tumorigenesis 

    TSG101 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TSG101: Tsg101tm1.1Kuw Tsg101tm1Mak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSG101 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSG101

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSG101 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSG101 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSG101
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TSG101 (see all 18):
    hsa-miR-106a hsa-miR-1285 hsa-miR-519a hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidTSG101 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSG101
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSG101

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSG101
    Sirion Biotech Customized adenovirus for overexpression of TSG101

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TSG101 (see all 7)
    OriGene ORF clones in mouse, rat for TSG101
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSG101 (NM_006292)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSG101
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSG101
    Sirion Biotech Customized lentivirus for stable overexpression of TSG101 
                         Customized lentivirus expression plasmids for stable overexpression of TSG101 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSG101
    Search LifeMap BioReagents cell lines for TSG101
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSG101


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TSG101 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    2Membrane binding and targetting of GAG proteins
    Membrane binding and targetting of GAG proteins0.85
    Synthesis And Processing Of GAG, GAGPOL Polyproteins0.85
    Assembly Of The HIV Virion0.85
    3Endosomal Sorting Complex Required For Transport (ESCRT)
    Endosomal Sorting Complex Required For Transport (ESCRT)0.71
    Budding and maturation of HIV virion0.71
    4Normal wtCFTR traffic / Sorting endosome formation
    Delta508-CFTR traffic / Sorting endosome formation in CF0.77
    5GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TSG101
        Breast Cancer Regulation by Stathmin1

    2 GeneGo (Thomson Reuters) Pathways for TSG101
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF

    2 BioSystems Pathways for TSG101
        Glucocorticoid receptor regulatory network
    Internalization of ErbB1

    5/10        Reactome Pathways for TSG101 (see all 10)
        Late Phase of HIV Life Cycle
    Membrane Trafficking
    Budding and maturation of HIV virion
    Synthesis And Processing Of GAG, GAGPOL Polyproteins
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1         Kegg Pathway  (Kegg details for TSG101):
        Endocytosis


    TSG101 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSG101

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/923 Interacting proteins for TSG101 (Q998161, 2, 3 ENSP000002519684) via UniProtKB, MINT, STRING, and/or I2D (see all 923)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP55Q53EZ41, 2, 3, ENSP000003605404EBI-346882,EBI-747776 MINT-6173601 MINT-6169549 MINT-6173584 MINT-6173720 MINT-6175155 MINT-6173676 MINT-6173387 MINT-6173737 MINT-6173542 I2D: score=5 STRING: ENSP00000360540
    HGSO149642, 3, ENSP000003312014MINT-50310 MINT-50311 MINT-50312 MINT-50313 MINT-68474 I2D: score=8 STRING: ENSP00000331201
    ENSG00000206206Q9UER71, 3EBI-346882,EBI-77321 I2D: score=2 
    ENSG00000206279Q9UER71, 3EBI-346882,EBI-77321 I2D: score=2 
    ENSG00000227046Q9UER71, 3EBI-346882,EBI-77321 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0006464cellular protein modification process IEA--
    GO:0007050cell cycle arrest IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0015031protein transport IEA--

    TSG101 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TSG101 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSG101 (TS101)

    7 Novoseek inferred chemical compound relationships for TSG101 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ptap 95.2 16 12915533 (3), 12663786 (2), 12379843 (2), 15163754 (1) (see all 11)
    adriamycin 4.44 2 15044860 (1), 15197357 (1)
    vincristine 1.12 3 15044860 (2), 15197357 (1)
    tyrosine 1.05 7 12802020 (1), 18716056 (1), 12900394 (1), 19808888 (1) (see all 7)
    leucine 0 2 12663786 (1)
    estrogen 0 2 9588212 (1), 10440698 (1)
    testosterone 0 6 14761944 (5), 10440698 (1)

    Search CenterWatch for drugs/clinical trials and news about TSG101 / TS101

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSG101 gene: 
    NM_006292.3  

    Unigene Cluster for TSG101:

    Tumor susceptibility gene 101
    Hs.523512  [show with all ESTs]
    Unigene Representative Sequence: BM542397
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536719 ENST00000580814 ENST00000584526 ENST00000251968(uc001mor.3 uc001mos.2 uc009yhs.2)
    ENST00000540555 ENST00000545247 ENST00000543054 ENST00000543087 ENST00000544804
    ENST00000438874 ENST00000542488 ENST00000535077 ENST00000357193
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSG101
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TSG101 (see all 18):
    hsa-miR-106a hsa-miR-1285 hsa-miR-519a hsa-miR-93 hsa-miR-7-1* hsa-miR-526b* hsa-miR-17 hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidTSG101 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSG101
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSG101
    Clone
    Products:
         
    OriGene clones in human, mouse for TSG101 (see all 7)
    OriGene ORF clones in mouse, rat for TSG101
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSG101 (NM_006292)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSG101
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSG101
    Sirion Biotech Customized lentivirus for stable overexpression of TSG101 
                         Customized lentivirus expression plasmids for stable overexpression of TSG101 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSG101
    OriGene qSTAR qPCR primer pairs in human, mouse for TSG101
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSG101
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSG101
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSG101

    Additional mRNA sequence: 

    AK130787.1 AY207473.1 AY207474.1 BC002487.1 U82130.1 

    14 DOTS entries:

    DT.453312  DT.100878565  DT.95255424  DT.40111610  DT.100878556  DT.91759345  DT.95255430  DT.75123290 
    DT.100704034  DT.100061070  DT.120699775  DT.40123689  DT.65288214  DT.91759346 

    24/365 AceView cDNA sequences (see all 365):

    BU619378 BP378195 CF242965 CA843510 AI280091 AW189724 CB123589 BP335705 
    BQ230430 BM771131 BX402450 BP382018 BM838498 BX402728 AW189684 BG939944 
    BM465820 CR598203 AA668848 CR623726 BU180842 BE465282 BI906734 BM782179 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSG101 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGTCTTCT
    TSG101 Expression
    About this image


    See TSG101 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSG101

    SOURCE GeneReport for Unigene cluster: Hs.523512

    UniProtKB/Swiss-Prot: TS101_HUMAN, Q99816
    Tissue specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including TSG101: 
              HIV Host Response in human mouse rat
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TSG101
    OriGene qSTAR qPCR primer pairs in human, mouse for TSG101
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSG101
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSG101
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSG101
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSG101

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TSG101 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsg1011 , 5 tumor susceptibility gene 1011, 5 89.57(n)1
    94.87(a)1
      7 (30.62 cM)5
    220881  NM_021884.31  NP_068684.11 
     468889495 
    chicken
    (Gallus gallus)
    Aves UEVLD1 UEV and lactate/malate dehyrogenase domains 80.93(n)
    90.98(a)
      423082  XM_003641342.1  XP_003641390.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSG1016
    Uncharacterized protein
    91(a)
    1 ↔ 1
    1(67814852-67847723)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143952 Xenopus laevis transcribed sequence with moderate similarity more 79.44(n)    CA972577.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsg1011 tumor susceptibility gene 101 74.72(n)
    85.71(a)
      415179  NM_001002089.1  NP_001002089.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TSG1011 , 3 tumor suppressor protein 1011 48(a)3
    54.91(n)1
    54.74(a)1
      73D13
    398811  NM_079396.31  NP_524120.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tsg-1011 Protein TSG-101 51.59(n)
    44.41(a)
      182474  NM_067963.2  NP_500364.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STP22(YCL008C)4
    STP221
    Component of the ESCRT-I complex, which is involved more4
    Stp22p1
    40.84(n)1
    28.83(a)1
      3(106853-105696)4
    8503491, 4  NP_009919.31, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ELC1 protein ELC 45.18(n)
    35.24(a)
      820419  NM_112075.2  NP_566423.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08333001 hypothetical protein 41.62(n)
    32.21(a)
      4331267  NM_001055169.1  NP_001048634.1 


    ENSEMBL Gene Tree for TSG101 (if available)
    TreeFam Gene Tree for TSG101 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSG101 gene
    1 SIMAP similar gene for TSG101 using alignment to 7 protein entries:     TS101_HUMAN (see all proteins):
    UEVLD

    TSG101 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/980 SNPs in TSG101 are shown (see all 980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011684381,2
    C--18425957(-) GCAGGG/TCCAAA 1 -- ds50010--------
    rs22917511,2
    C,F,H--18426067(+) CACAGA/GTAAGT 1 -- ds500132Minor allele frequency- G:0.18EA NA NS MN CSA 4616
    rs1473983751,2
    --18426134(+) CCATG-/TTAA  
            
    TTAAT
    1 -- ds50010--------
    rs22917521,2
    C,F,O,A,H--18426141(+) TAATTC/TACTTT 1 -- ds500126Minor allele frequency- T:0.26EA NA NS MN 4004
    rs1923871911,2
    --18426235(+) TTTCAC/TGGATC 1 -- ds50010--------
    rs22917531,2
    C,F,H--18426247(+) TTCCTA/CAAGTC 1 -- ds500122Minor allele frequency- C:0.12EA MN NS NA 3984
    rs1433960511,2
    --18426261(+) TAAAGA/GAGAGA 1 -- ds50010--------
    rs1837850981,2
    --18426351(+) AAAGCC/TAGTCT 1 -- ut310--------
    rs22917541,2
    C,F,H--18426431(+) ACTTAT/CTCTGG 1 -- ut3114Minor allele frequency- C:0.03EA NA MN NS 2572
    rs153871,2
    C--18426450(-) TCCTTT/ATATCA 1 -- ut31 trp36Minor allele frequency- A:0.00MN 584

    HapMap Linkage Disequilibrium report for TSG101 (18489883 - 18548779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSG101:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820064CNV Loss19587683
    nsv467719CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSG101
    DNA2.0 Custom Variant and Variant Library Synthesis for TSG101

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601387    OMIM disorders: --

    20/34 diseases for TSG101 (see all 34):    About MalaCards
    hepatitis e    japanese encephalitis    vesiculitis    breast cancer
    tooth disease    charcot-marie-tooth disease    familial breast cancer    human t-cell leukemia virus type 1
    cervicitis    soft tissue sarcoma    cervical cancer    wiskott-aldrich syndrome
    hiv type 1    encephalitis    endometrial carcinoma    papillary thyroid carcinoma
    burkitt's lymphoma    ovarian cancer    t-cell leukemia    herpes simplex


    TSG101 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/21 Novoseek inferred disease relationships for TSG101 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 55.7 18 12388682 (2), 16809281 (2), 17182674 (2), 12915533 (1) (see all 15)
    tumors 41.2 100 11838966 (5), 10618725 (4), 9588212 (4), 14991575 (3) (see all 49)
    breast cancer 38.1 43 10930114 (4), 9019400 (4), 9849457 (3), 9652749 (3) (see all 24)
    leukemia t-cell 37.3 1 14581525 (1)
    cervical carcinoma 27.7 4 10505033 (2), 10027311 (1)
    charcot-marie-tooth disease 25.3 2 15776429 (1), 16118794 (1)
    leukemia 22.6 8 10664246 (3), 14526201 (1), 9722303 (1), 12743307 (1) (see all 5)
    somatic mutations 21.4 2 9253709 (1), 9366528 (1)
    ovarian cancer 21.1 18 17606716 (5), 9773405 (4), 17110434 (3), 9530348 (1) (see all 5)
    cancer 18.9 27 17369844 (3), 9652749 (2), 10618725 (1), 10202180 (1) (see all 16)

    Genetic Association Database (GAD): TSG101
    Human Genome Epidemiology (HuGE) Navigator: TSG101 (5 documents)
    Tumor Gene Database (TGDB): TSG101

    Export disorders for TSG101 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSG101 gene, integrated from 9 sources (see all 273):
    (articles sorted by number of sources associating them with TSG101)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. (PubMed id 9019400)1, 2, 3, 9 Li L.... Cohen S.N. (1997)
    2. Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours. (PubMed id 9366528)1, 2, 9 Gayther S.A.... Caldas C. (1997)
    3. Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants. (PubMed id 9840940)1, 2, 9 Wagner K.-U....Hennighausen L. (1998)
    4. HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. (PubMed id 12900394)1, 2, 9 Pornillos O.... Sundquist W.I. (2003)
    5. Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101. (PubMed id 19520058)1, 2, 9 Okumura M.... Maki M. (2009)
    6. PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. (PubMed id 14581525)1, 2, 9 Bouamr F.... Goff S.P. (2003)
    7. TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. (PubMed id 12802020)1, 2, 9 Lu Q....Cohen S.N. (2003)
    8. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. (PubMed id 15509564)1, 2, 9 Eastman S.W.... Bieniasz P.D. (2005)
    9. Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. (PubMed id 12379843)1, 2, 9 Pornillos O.... Sundquist W.I. (2002)
    10. Structure and functional interactions of the Tsg101 UEV domain. (PubMed id 12006492)1, 2, 9 Pornillos O.W....Sundquist W.I. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7251 HGNC: 15971 AceView: TSG101 Ensembl:ENSG00000074319 euGenes: HUgn7251
    ECgene: TSG101 Kegg: 7251 H-InvDB: TSG101

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSG101 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSG101 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSG101 gene:
    Search GeneIP for patents involving TSG101

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TSG101   OriGene RNAi products in human, mouse, rat for TSG101  
     OriGene qPCR primer pairs and template standards for TSG101   OriGene Protein Over-expression Lysate for TSG101  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TSG101  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSG101   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TSG101   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSG101   OriGene Custom Protein Services for TSG101  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSG101
     QIAGEN SeqTarget long-range PCR primers for resequencing TSG101
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSG101
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSG101
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSG101
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSG101
     GenScript Custom Purified and Recombinant Proteins Services for TSG101 GenScript cDNA clones with any tag delivered in your preferred vector for TSG101
     GenScript Custom Assay Services for TSG101 GenScript Custom Superior Antibodies Services for TSG101
     GenScript Custom overexpressing Cell Line Services for TSG101 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSG101 promoter
     Search Chromatin IP Primers for TSG101
     RT2 qPCR Primer Assay in human, mouse, rat TSG101
     GNC Network for TSG101
     SABiosciences PCR Arrays including human, mouse, rat TSG101
     Search Tocris compounds for TSG101 (TS101)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSG101 antibodies
     TSG101 proteins
     TSG101 lysates
     Antibodies for TSG101
     See all of Abcam's Antibodies, Kits and Proteins for TSG101
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TSG101




     Proteins for TSG101
     Antibodies for TSG101
     ELISAs for TSG101
     CLIAs for TSG101
     Search LifeMap BioReagents cell lines for TSG101
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSG101
     SwitchGear 3'UTR luciferase reporter plasmids for TSG101
     SwitchGear Promoter luciferase reporter plasmids for TSG101
     ThermoFisher Antibody for TSG101
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSG101
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TSG101
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSG101
    Customized:
     lentivirus for stable overexpression of TSG101
     lentivirus expression plasmids for stable overexpression of TSG101
     adenovirus for overexpression of TSG101
     LSBio Antibodies in human, mouse, rat for TSG101
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSG101 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4