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Aliases for TSG101 Gene

Aliases for TSG101 Gene

  • Tumor Susceptibility 101 2 3
  • ESCRT-I Complex Subunit TSG101 3 4
  • Tumor Susceptibility Gene 101 2 3
  • Tumor Susceptibility Gene 10 2 3
  • Tumor Susceptibility Gene 101 Protein 3
  • Tumor Susceptibility Protein 3
  • VPS23 3
  • TSG10 3

External Ids for TSG101 Gene

Previous HGNC Symbols for TSG101 Gene

  • TSG10

Previous GeneCards Identifiers for TSG101 Gene

  • GC11M019623
  • GC11M019444
  • GC11M018541
  • GC11M018466
  • GC11M018458
  • GC11M018501
  • GC11M018187

Summaries for TSG101 Gene

Entrez Gene Summary for TSG101 Gene

  • The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSG101 Gene

TSG101 (Tumor Susceptibility 101) is a Protein Coding gene. Diseases associated with TSG101 include breast cancer and hiv-1. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include transcription corepressor activity and ubiquitin binding.

UniProtKB/Swiss-Prot for TSG101 Gene

  • Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.

Gene Wiki entry for TSG101 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSG101 Gene

Genomics for TSG101 Gene

Regulatory Elements for TSG101 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSG101 Gene

Start:
18,468,336 bp from pter
End:
18,527,232 bp from pter
Size:
58,897 bases
Orientation:
Minus strand

Genomic View for TSG101 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSG101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSG101 Gene

Proteins for TSG101 Gene

  • Protein details for TSG101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99816-TS101_HUMAN
    Recommended name:
    Tumor susceptibility gene 101 protein
    Protein Accession:
    Q99816
    Secondary Accessions:
    • Q9BUM5

    Protein attributes for TSG101 Gene

    Size:
    390 amino acids
    Molecular mass:
    43944 Da
    Quaternary structure:
    • Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with VPS37A, VPS37B and VPS37C. Interacts with ubiquitin, stathmin, GMCL, DMAP1 and AATF (By similarity). Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with HGS; the interaction mediates the association with the ESCRT-0 complex. Interacts with GGA1 and GGA3. Interacts (via UEV domain) with PDCD6IP/AIP1. Interacts with VPS28, SNF8 and VPS36. Self-associates. Interacts with MVB12A; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D. Interacts with LRSAM1. Interacts with CEP55; the interaction is required for cytokinesis but not for viral budding. Interacts with PDCD6. Interacts with HIV-1 p6. Interacts with human spumavirus Gag. Interacts with HTLV-1 Gag. Interacts with Ebola virus VP40. Interacts with EIAV p9; the interaction has been shown in vitro. Interacts with MGRN1.

    Three dimensional structures from OCA and Proteopedia for TSG101 Gene

    Alternative splice isoforms for TSG101 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSG101 Gene

Proteomics data for TSG101 Gene at MOPED

Post-translational modifications for TSG101 Gene

  • Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1.
  • Ubiquitination at Lys237 and Lys361
  • Modification sites at PhosphoSitePlus

Other Protein References for TSG101 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TSG101 Gene

Domains for TSG101 Gene

Graphical View of Domain Structure for InterPro Entry

Q99816

UniProtKB/Swiss-Prot:

TS101_HUMAN :
  • Q99816
Domain:
  • The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein
  • The coiled coil domain may interact with stathmin
  • The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently
  • Contains 1 SB (steadiness box) domain.
  • Contains 1 UEV (ubiquitin E2 variant) domain.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
genes like me logo Genes that share domains with TSG101: view

No data available for Gene Families for TSG101 Gene

Function for TSG101 Gene

Molecular function for TSG101 Gene

GENATLAS Biochemistry:
murine tumor susceptibility gene 101 (Tsg101) homolog,43kDa,transcriptional suppressor for ESRR and other nuclear hormone receptors,mutated in primary breast carcinoma,aberrantly spliced in small cell lung carcinoma and in cervical,endometrial,hormone refractory prostate cancer,involved in cell cycle regulation
UniProtKB/Swiss-Prot Function:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.

Gene Ontology (GO) - Molecular Function for TSG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10888872
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 14505570
GO:0031625 ubiquitin protein ligase binding IPI 17229889
GO:0042803 protein homodimerization activity IPI 14519844
genes like me logo Genes that share ontologies with TSG101: view
genes like me logo Genes that share phenotypes with TSG101: view

Animal Models for TSG101 Gene

MGI Knock Outs for TSG101:

Animal Model Products

miRNA for TSG101 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSG101

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TSG101 Gene

Localization for TSG101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSG101 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSG101 Gene COMPARTMENTS Subcellular localization image for TSG101 gene
Compartment Confidence
endosome 5
nucleus 5
plasma membrane 4
cytosol 3
lysosome 2
vacuole 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IDA 18005716
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm ISS --
GO:0005768 endosome IDA 17940959
GO:0005769 early endosome IDA 11916981
genes like me logo Genes that share ontologies with TSG101: view

Pathways for TSG101 Gene

genes like me logo Genes that share pathways with TSG101: view

Pathways by source for TSG101 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Cycle in human,mouse,rat
    • HIV Host Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for TSG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0006464 cellular protein modification process IEA --
GO:0007050 cell cycle arrest IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TSG101: view

Compounds for TSG101 Gene

(7) Novoseek inferred chemical compound relationships for TSG101 Gene

Compound -log(P) Hits PubMed IDs
ptap 95.2 15
adriamycin 4.44 2
vincristine 1.12 3
tyrosine 1.05 7
leucine 0 1
genes like me logo Genes that share compounds with TSG101: view

Transcripts for TSG101 Gene

Unigene Clusters for TSG101 Gene

Tumor susceptibility gene 101:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSG101

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSG101 Gene

No ASD Table

Relevant External Links for TSG101 Gene

GeneLoc Exon Structure for
TSG101
ECgene alternative splicing isoforms for
TSG101

Expression for TSG101 Gene

mRNA expression in normal human tissues for TSG101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TSG101 Gene

This gene is overexpressed in Urine (9.5) and Bone (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSG101 Gene

SOURCE GeneReport for Unigene cluster for TSG101 Gene Hs.523512

mRNA Expression by UniProt/SwissProt for TSG101 Gene

Q99816-TS101_HUMAN
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas
genes like me logo Genes that share expressions with TSG101: view

Expression partners for TSG101 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TSG101 Gene

Orthologs for TSG101 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSG101 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSG101 35
  • 94.1 (n)
  • 97.69 (a)
TSG101 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSG101 35
  • 94.62 (n)
  • 97.95 (a)
TSG101 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsg101 35
  • 89.57 (n)
  • 94.87 (a)
Tsg101 16
Tsg101 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSG101 35
  • 99.91 (n)
  • 100 (a)
TSG101 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsg101 35
  • 89.15 (n)
  • 93.85 (a)
oppossum
(Monodelphis domestica)
Mammalia TSG101 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSG101 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSG101 35
  • 78.83 (n)
  • 88.95 (a)
TSG101 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSG101 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76193 35
tsg101 35
  • 72.7 (n)
  • 82.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14395 35
zebrafish
(Danio rerio)
Actinopterygii tsg101a 35
  • 73.14 (n)
  • 83.99 (a)
TSG101 (1 of 5) 36
  • 75 (a)
OneToMany
TSG101 (3 of 5) 36
  • 40 (a)
OneToMany
TSG101 (4 of 5) 36
  • 95 (a)
OneToMany
TSG101 (5 of 5) 36
  • 39 (a)
OneToMany
tsg101a 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TSG101 37
  • 48 (a)
TSG101 35
  • 54.39 (n)
  • 53.68 (a)
TSG101 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005934 35
  • 56.93 (n)
  • 54.27 (a)
worm
(Caenorhabditis elegans)
Secernentea tsg-101 35
  • 50.27 (n)
  • 42.97 (a)
tsg-101 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STP22 36
  • 23 (a)
OneToOne
STP22 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ELC 35
  • 44.31 (n)
  • 34.12 (a)
rice
(Oryza sativa)
Liliopsida Os02g0833300 35
  • 42.26 (n)
  • 32.92 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2157 35
Species with no ortholog for TSG101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSG101 Gene

ENSEMBL:
Gene Tree for TSG101 (if available)
TreeFam:
Gene Tree for TSG101 (if available)

Paralogs for TSG101 Gene

Selected SIMAP similar genes for TSG101 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TSG101: view

No data available for Paralogs for TSG101 Gene

Variants for TSG101 Gene

Sequence variations from dbSNP and Humsavar for TSG101 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8018 -- 18,481,759(-) GTTAT(C/T)ATTCC reference, synonymous-codon
rs15387 -- 18,480,490(-) TCCTT(A/T)TATCA utr-variant-3-prime
rs171496 -- 18,521,609(-) gttga(A/G)aggat intron-variant
rs181714 -- 18,517,200(-) cattt(C/T)taaaa intron-variant
rs193329 -- 18,521,586(-) tttga(A/G)aacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSG101 Gene

Variant ID Type Subtype PubMed ID
nsv467719 CNV Gain 19166990
nsv820064 CNV Loss 19587683

Relevant External Links for TSG101 Gene

HapMap Linkage Disequilibrium report
TSG101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSG101 Gene

Disorders for TSG101 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TSG101 Gene in MalaCards »

(2) Diseases for TSG101 Gene including...

(1) OMIM Diseases for TSG101 Gene (601387)

(21) Novoseek inferred disease relationships for TSG101 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 55.7 18
tumors 41.2 79
breast cancer 38.1 39
leukemia t-cell 37.3 1
cervical carcinoma 27.7 3

Relevant External Links for TSG101

Genetic Association Database (GAD)
TSG101
Human Genome Epidemiology (HuGE) Navigator
TSG101
Tumor Gene Database (TGDB):
TSG101
genes like me logo Genes that share disorders with TSG101: view

No data available for UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for TSG101 Gene

Publications for TSG101 Gene

  1. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. (PMID: 9019400) Li L. … Cohen S.N. (Cell 1997) 2 3 4 23
  2. Aberrant splicing but not mutations of TSG101 in human breast cancer. (PMID: 9242438) Lee M.P. … Feinberg A.P. (Cancer Res. 1997) 3 4 23
  3. Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours. (PMID: 9366528) Gayther S.A. … Caldas C. (Oncogene 1997) 3 4 23
  4. Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants. (PMID: 9840940) Wagner K.-U. … Hennighausen L. (Oncogene 1998) 3 4 23
  5. Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. (PMID: 11916981) Bishop N. … Woodman P. (J. Cell Biol. 2002) 3 4 23

Products for TSG101 Gene

Sources for TSG101 Gene

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