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TSFM Gene

protein-coding   GIFtS: 58
GCID: GC12P058176

Ts Translation Elongation Factor, Mitochondrial

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ts Translation Elongation Factor, Mitochondrial1 2     Mitochondrial Elongation Factor Ts2
EFTS2     EF-Ts3
EFTSMT2     EF-TsMt3
Elongation Factor Ts, Mitochondrial2     COXPD35

External Ids:    HGNC: 123671   Entrez Gene: 101022   Ensembl: ENSG000001232977   OMIM: 6047235   UniProtKB: P438973   

Export aliases for TSFM gene to outside databases

Previous GC identifers: GC12P057778 GC12P058319 GC12P057893 GC12P056462 GC12P058167 GC12P055213


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSFM Gene:
This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes
the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of
mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation
deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Mar 2010)

GeneCards Summary for TSFM Gene:
TSFM (Ts translation elongation factor, mitochondrial) is a protein-coding gene. Diseases associated with TSFM include combined oxidative phosphorylation deficiency 3, and atypical lipomatous tumor. GO annotations related to this gene include translation elongation factor activity.

UniProtKB/Swiss-Prot: EFTS_HUMAN, P43897
Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the
aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)

Gene Wiki entry for TSFM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSFM gene promoter:
         CREB   deltaCREB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSFM promoter sequence
   Search Chromatin IP Primers for TSFM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSFM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14.1

TSFM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSFM gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P058176:  view genomic region     (about GC identifiers)

Start:
58,176,372 bp from pter      End:
58,201,854 bp from pter
Size:
25,483 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EFTS_HUMAN, P43897 (See protein sequence)
Recommended Name: Elongation factor Ts, mitochondrial precursor  
Size: 325 amino acids; 35391 Da
1 PDB 3D structure from and Proteopedia for TSFM:
2CP9 (3D)    
Secondary accessions: B4E391 F5H2T7 Q561V7 Q8TBC2 Q9UQK0
Alternative splicing: 4 isoforms:  P43897-1   P43897-2   P43897-3   P43897-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSFM: NX_P43897

Explore proteomics data for TSFM at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys192
  • Modification sites at PhosphoSitePlus

  • See TSFM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001166166.1  NP_001166167.1  NP_001166168.1  NP_005717.3  

    ENSEMBL proteins: 
     ENSP00000388330   ENSP00000313877   ENSP00000406339   ENSP00000448575   ENSP00000450041  
     ENSP00000390679   ENSP00000389162   ENSP00000439342   ENSP00000440987   ENSP00000242983  

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    Novus Biologicals TSFM Proteins
    Novus Biologicals TSFM Lysates
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    Cloud-Clone Corp. Proteins for TSFM

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    Cloud-Clone Corp. CLIAs for TSFM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001816 Transl_elong_EFTs/EF1B
     IPR018101 Transl_elong_Ts_CS
     IPR009060 UBA-like
     IPR000449 UBA/Ts_N
     IPR014039 Transl_elong_EFTs/EF1B_dimer

    Graphical View of Domain Structure for InterPro Entry P43897

    ProtoNet protein and cluster: P43897

    1 Blocks protein domain: IPB014039 Translation elongation factor EFTs/EF1B

    UniProtKB/Swiss-Prot: EFTS_HUMAN, P43897
    Similarity: Belongs to the EF-Ts family


    TSFM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFTS_HUMAN, P43897
    Function: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the
    aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003746translation elongation factor activity IEA--
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    TSFM for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tsfm):
     mortality/aging  pigmentation  vision/eye 

    TSFM for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSFM
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSFM

    miRNA
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    miRTarBase miRNAs that target TSFM:
    hsa-mir-331-3p (MIRT043452), hsa-mir-26b-5p (MIRT029759), hsa-mir-877-3p (MIRT036967), hsa-mir-25-3p (MIRT050350)

    Block miRNA regulation of human, mouse, rat TSFM using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TSFM:
    hsa-miR-3671 hsa-miR-607 hsa-miR-593 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidTSFM 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSFM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSFM

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSFM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EFTS_HUMAN, P43897: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    chloroplast1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion IDA--

    TSFM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSFM
    Interactions:

        GeneGlobe Interaction Network for TSFM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for TSFM (P438972, 3 ENSP000003883304) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3297510 I2D: score=1 STRING: ENSP00000309503
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    NLKQ9UBE83, ENSP000003846254I2D: score=1 STRING: ENSP00000384625
    DYNC1H1Q142043, ENSP000003489654I2D: score=1 STRING: ENSP00000348965
    LMAN1P492573I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006414translational elongation TAS7615523
    GO:0032784regulation of DNA-templated transcription, elongation TAS7615523

    TSFM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSFM (EFTS)

    1 HMDB Compound for TSFM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 Novoseek inferred chemical compound relationships for TSFM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 79.3 15 1772451 (2), 1804111 (2), 14715237 (1), 15581367 (1) (see all 7)
    aminoacyl-trna 77.6 2 1508161 (1), 11771276 (1)
    gtp 71.1 20 1804111 (3), 14715237 (2), 1508161 (2), 1896033 (1) (see all 9)
    phenylalanine 25.3 1 8765000 (1)
    magnesium 13.2 1 17397188 (1)



    TSFM for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSFM gene (4 alternative transcripts): 
    NM_001172695.1  NM_001172696.1  NM_001172697.1  NM_005726.5  

    Unigene Cluster for TSFM:

    Ts translation elongation factor, mitochondrial
    Hs.632704  [show with all ESTs]
    Unigene Representative Sequence: NM_001172696
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454289(uc001sqh.3 uc001sqi.3 uc010sse.2) ENST00000323833
    ENST00000417094 ENST00000550559 ENST00000548851 ENST00000434359 ENST00000457189
    ENST00000497617 ENST00000543727(uc021qzq.1) ENST00000540550(uc010ssf.2)
    ENST00000350762
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TSFM:
    hsa-miR-3671 hsa-miR-607 hsa-miR-593 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidTSFM 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TSFM
    Predesigned siRNA for gene silencing in human, mouse, rat TSFM
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): TSFM (NM_005726)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSFM
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSFM
      QuantiTect SYBR Green Assays in human, mouse, rat TSFM
      QuantiFast Probe-based Assays in human, mouse, rat TSFM

    Additional mRNA sequence: 

    AF110399.1 AK295323.1 AK304621.1 AK308981.1 AK313453.1 BC022862.1 BC093068.1 L37936.1 

    16 DOTS entries:

    DT.112342  DT.100787388  DT.102841113  DT.100787386  DT.91714740  DT.100787387  DT.121200918  DT.100787389 
    DT.100787390  DT.121200921  DT.443182  DT.121200899  DT.121200947  DT.437665  DT.92352317  DT.95128382 

    Selected AceView cDNA sequences (see all 276):

    CR622683 BM048745 AW468471 BF195986 BE791411 AI985184 CF127362 AI633093 
    AF110399 BM836337 BM723458 AL556814 AI478614 AU122778 BE741613 BE254769 
    AL050100 CR592271 CA447783 BM699533 CD109202 CK823940 BC016395 BU618940 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TSFM    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                          -     -           -                                             
    SP2:                          -     -           -                 -                           
    SP3:                                                              -                           
    SP4:                                -           -                 -                           
    SP5:                                            -                 -                           


    ECgene alternative splicing isoforms for TSFM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSFM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAAAATTA
    TSFM Expression
    About this image

    TSFM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSFM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632704

    UniProtKB/Swiss-Prot: EFTS_HUMAN, P43897
    Tissue specificity: Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and
    kidney

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    QuantiFast Probe-based Assays in human, mouse, rat TSFM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSFM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSFM gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsfm1 , 5 Ts translation elongation factor, mitochondrial1, 5 84.72(n)1
    86.54(a)1
      10 (74.50 cM)5
    663991  NM_025537.31  NP_079813.11 
     1270115725 
    lizard
    (Anolis carolinensis)
    Reptilia TSFM6
    Ts translation elongation factor, mitochondrial
    61(a)
    1 ↔ 1
    2(66961606-66976869)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.164622 Xenopus laevis transcribed sequence with weak similarity more 74.14(n)    BQ730744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsfm1 Ts translation elongation factor, mitochondrial 56.9(n)
    52.07(a)
      567785  NM_001080035.1  NP_001073504.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64121 , 3 translational elongation translation
    elongation more3
    CG64121
    37(a)3
    49.94(n)1
    42.59(a)1
      36C103
    350601  NM_136003.41  NP_609847.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tsfm-11 tsfm-1 45.43(n)
    38.22(a)
      179683  NM_073678.5  NP_506079.1 


    ENSEMBL Gene Tree for TSFM (if available)
    TreeFam Gene Tree for TSFM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSFM (see all 450)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0689734
    Combined oxidative phosphorylation deficiency 3 (COXPD3)4--see VAR_0689732 R W mis40--------
    rs1219094851,2
    Cpathogenic158024765(+) TTGTGC/TGGTTT 6 R W mis1 ut31 int10--------
    rs664729411,2
    C--55212208(+) TGTAT-/GTTCTT 4 -- us2k10--------
    rs2005182181,2
    C--55220809(+) TCTTTC/TTTTTT 4 -- int10--------
    rs111723341,2
    --58009274(+) CTGTGA/GGAttt 4 -- us2k10--------
    rs1115430721,2
    C--58009396(+) ATCTTC/-CTGCC 4 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1509040871,2
    --58009436(+) CATGCA/GCCACC 4 -- us2k10--------
    rs111723351,2
    C,F,A,H--58009645(+) GAACCC/TAACTT 4 -- us2k123Minor allele frequency- T:0.32NS EA NA WA 2488
    rs1914010811,2
    --58009675(+) GAAGAA/CGCCTC 4 -- us2k10--------
    rs2017358761,2
    C--58009795(+) CTGTAG/TTTCTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSFM (58176372 - 58201854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TSFM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899121CNV Loss21882294
    nsv510601CNV Loss20534489
    nsv470296CNV Loss18288195
    nsv470297CNV Gain18288195

    Human Gene Mutation Database (HGMD): TSFM
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604723   
    OMIM disorders: 610505  
    UniProtKB/Swiss-Prot: EFTS_HUMAN, P43897
  • Combined oxidative phosphorylation deficiency 3 (COXPD3) [MIM:610505]: A mitochondrial disease resulting
    in severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe
    defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative
    phosphorylation complexes. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 15 diseases for TSFM:    
    About MalaCards
    combined oxidative phosphorylation deficiency 3    atypical lipomatous tumor    scrub typhus    typhus
    q fever    mitochondrial encephalomyopathy    encephalomyopathy    mitochondrial disorders
    metabolic acidosis    hypertrophic cardiomyopathy    pneumonia    tuberculosis
    malaria    multiple myeloma    myeloma


    TSFM for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSFM
    Human Genome Epidemiology (HuGE) Navigator: TSFM (1 document)

    Export disorders for TSFM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSFM gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with TSFM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver. (PubMed id 7615523)1, 2, 3, 9 Xin H.... Spremulli L.L. (J. Biol. Chem. 1995)
    2. Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs. (PubMed id 17033963)1, 2, 9 Smeitink J.A.M....Shoubridge E.A. (Am. J. Hum. Genet. 2006)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1. (PubMed id 16632485)1, 9 Antonicka H....Shoubridge E.A. (Hum. Mol. Genet. 2006)
    6. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (Nucleic Acids Res. 2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Mutation in the mitochondrial translation elongation factor EFTs results in severe infantile liver failure. (PubMed id 21741925)1 Vedrenne V....RAPtig A. (J. Hepatol. 2012)
    9. Genomic analysis of mitochondrial diseases in a consanguineous population reveals novel candidate disease genes. (PubMed id 22499341)2 Shamseldin H.E.... Alkuraya F.S. (J. Med. Genet. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10102 HGNC: 12367 AceView: TSFMandDKFZP586D0919 Ensembl:ENSG00000123297 euGenes: HUgn10102
    ECgene: TSFM H-InvDB: TSFM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSFM Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TSFM[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSFM gene:
    Search GeneIP for patents involving TSFM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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