Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSEN34 Gene

protein-coding   GIFtS: 52
GCID: GC19P054849

tRNA splicing endonuclease 34 homolog (S. cerevisiae)

(Previous names: leukocyte receptor cluster (LRC) member 5, tRNA splicing...)
(Previous symbol: LENG5)
 Explore 6 diseases affiliated with
TSEN34 via our new
 Human Malady Compendium 
Biological research products
for TSEN34
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TRNA Splicing Endonuclease 34 Homolog (S. Cerevisiae)1 2     PCH2C2 5
LENG51 2 3 5     TRNA Splicing Endonuclease 34 Homolog (SEN34, S. Cerevisiae)1
SEN341 2 3 5     HsSen343
SEN34L1 2     TRNA-Splicing Endonuclease Subunit Sen342
Leukocyte Receptor Cluster (LRC) Member 51 2     EC 3.1.27.93
Leukocyte Receptor Cluster Member 52 3     HsSen343
TRNA-Intron Endonuclease Sen342 3     

External Ids:    HGNC: 155061   Entrez Gene: 790422   Ensembl: ENSG000001708927   OMIM: 6087545   UniProtKB: Q9BSV63   

Export aliases for TSEN34 gene to outside databases

Previous GC identifers: GC19P059387 GC19P054794 GC19P054801 GC19P051009 GC19P054812 GC19P054819 GC19P054826 GC19P054834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSEN34:
This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from
precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation
in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced
variants, encoding the same protein, have been identified.(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: SEN34_HUMAN, Q9BSV6
Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible
for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to
release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH
termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site
in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It
probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA
processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing
and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events

Gene Wiki entry for TSEN34


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSEN34 gene promoter:
         Egr-3   Pax-5   NRSF form 1   XBP-1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSEN34 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSEN34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

TSEN34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSEN34 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054849:  view genomic region     (about GC identifiers)

Start:
54,693,789 bp from pter      End:
54,698,394 bp from pter
Size:
4,606 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SEN34_HUMAN, Q9BSV6 (See protein sequence)
Recommended Name: tRNA-splicing endonuclease subunit Sen34  
Size: 310 amino acids; 33652 Da
Subunit: tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34/LENG5 and SEN54. tRNA splicing
endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and
CSTF2
Subcellular location: Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus
Miscellaneous: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4
Sequence caution: Sequence=BAB15284.1; Type=Erroneous termination; Positions=311; Note=Translated as stop;
Secondary accessions: A6NNB1 B0V3J1 Q9BVT1 Q9H6H5

Explore the universe of human proteins at neXtProt for TSEN34: NX_Q9BSV6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BSV6

  • TSEN34 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001070914.1  NP_076980.2  

    ENSEMBL proteins: 
     ENSP00000400743   ENSP00000408689   ENSP00000305524   ENSP00000379667   ENSP00000379671  
     ENSP00000397402  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TSEN34
    OriGene Custom Protein Services for TSEN34 
    GenScript Custom Purified and Recombinant Proteins Services for TSEN34
    Novus Biologicals TSEN34 Proteins
    Novus Biologicals TSEN34 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TSEN34

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000214tRNA-intron endonuclease complex IEA--
    GO:0005730nucleolus IEA--


    TSEN34 for ontologies           About GeneDecksing



    TSEN34 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSEN34 
    GenScript Custom Superior Antibodies Services for TSEN34
    Novus Biologicals TSEN34 Antibodies
    Search for Antibodies for TSEN34 at Abcam  
    Uscn Antibodies for TSEN34
    ThermoFisher Antibodies for TSEN34

    Assay Products for TSEN34: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSEN34
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TSEN34


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TSEN34 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006677 tRNA_intron_Endonuc_cat-like
     IPR006676 tRNA_splic
     IPR011856 tRNA_endonuc-like_dom
     IPR016690 tRNA_splic_SEN34

    Graphical View of Domain Structure for InterPro Entry Q9BSV6

    ProtoNet protein and cluster: Q9BSV6

    UniProtKB/Swiss-Prot: SEN34_HUMAN, Q9BSV6
    Similarity: Belongs to the tRNA-intron endonuclease family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SEN34_HUMAN, Q9BSV6
    Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible
    for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to
    release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH
    termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site
    in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It
    probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA
    processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing
    and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events
    Catalytic activity: Endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxy and 2',3'-cyclic phosphate termini, and
    specifically removing the intron

    Enzyme Number (IUBMB): EC 3.1.27.91

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): TSEN34
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSEN34
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate TSEN34 (see all 19):
    hsa-miR-142-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-302e hsa-miR-570 hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTSEN34 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSEN34 (see all 7)
    OriGene shRNA RFP: TSEN34
    OriGene siRNA: TSEN34
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN34

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSEN34

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN34 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN34 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TSEN34 (NM_001077446)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSEN34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN34 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSEN34
    Search LifeMap BioReagents cell lines for TSEN34

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN34

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000213tRNA-intron endonuclease activity IEA--
    GO:0003676nucleic acid binding IEA--
    GO:0004519endonuclease activity ----
    GO:0005515protein binding ----


    TSEN34 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TSEN34:
     Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSEN34

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for TSEN34 (Q9BSV63 ENSP000003055244) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSEN15Q8WW013, ENSP000003552994I2D: score=2 STRING: ENSP00000355299
    CLP1Q929893, ENSP000003047044I2D: score=1 STRING: ENSP00000304704
    TSEN2Q8NCE03, ENSP000002849954I2D: score=1 STRING: ENSP00000284995
    TSEN54Q7Z6J93, ENSP000003274874I2D: score=1 STRING: ENSP00000327487
    ACDQ96AP03I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000379tRNA-type intron splice site recognition and cleavage IEA--
    GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation ----
    GO:0006397mRNA processing IEA--


    TSEN34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSEN34
    Search CenterWatch for drugs/clinical trials and news about TSEN34 / SEN34 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSEN34 gene (2 alternative transcripts): 
    NM_001077446.2  NM_024075.3  

    Unigene Cluster for TSEN34:

    TRNA splicing endonuclease 34 homolog (S. cerevisiae)
    Hs.15580  [show with all ESTs]
    Unigene Representative Sequence: NM_024075
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455798 ENST00000456872 ENST00000302937(uc002qdu.3) ENST00000496583
    ENST00000396383(uc002qdv.3) ENST00000396388(uc002qdw.3) ENST00000429671(uc010yeo.2)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): TSEN34
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSEN34
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate TSEN34 (see all 19):
    hsa-miR-142-3p hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-302e hsa-miR-570 hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTSEN34 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSEN34 (see all 7)
    OriGene shRNA RFP: TSEN34
    OriGene siRNA: TSEN34
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN34
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN34 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN34 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TSEN34 (NM_001077446)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSEN34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN34 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSEN34
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSEN34
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN34
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN34

    Additional cDNA sequence: 

    AF211970.1 AK025929.1 AK225385.1 AK226013.1 AK300054.1 BC000944.2 BC004530.2 BC020805.1 

    14 DOTS entries:

    DT.80101582  DT.99980016  DT.95148719  DT.92440493  DT.100820210  DT.100820199  DT.100820209  DT.95148718 
    DT.99946438  DT.100738996  DT.102830132  DT.40268261  DT.95148710  DT.99991261 

    24/303 AceView cDNA sequences (see all 303):

    BC020805 BQ931834 AW473865 BG762576 BU508148 BG742801 BE777993 AI280860 
    CR607949 BG684154 AI587468 AA988242 BU623928 AA431799 CR600218 BM724260 
    BE787702 AA082793 CA488459 AI240925 BP368094 AA877114 AW304168 CR598135 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TSEN34 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                          -     -                                                                     
    SP2:                                -                                                                     
    SP3:        -     -     -     -     -                                                                     
    SP4:                    -     -     -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TSEN34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSEN34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGGGTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TSEN34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSEN34

    SOURCE GeneReport for Unigene cluster: Hs.15580
        SABiosciences Custom PCR Arrays for TSEN34
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSEN34
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSEN34
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN34
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN34
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSEN34 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsen341 , 5 tRNA splicing endonuclease 34 homolog (S. cerevisiae)1, 5 84.3(n)1
    89.35(a)1
      7 (2.13 cM)5
    660781  NM_001164204.11  NP_001157676.11 
     36933755 
    chicken
    (Gallus gallus)
    Aves LOC1008593681 tRNA-splicing endonuclease subunit Sen34-like 50.52(n)
    37.67(a)
      100859368  XM_003643569.1  XP_003643617.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSEN346
    --
    45(a)
    1 ↔ 1
    GL343279.1(1644295-1650312)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-203b8.31 si:ch211-203b8.3 53.48(n)
    45.52(a)
      565995  XM_689260.5  XP_694352.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG332606
    --
    22(a)
    1 ↔ 1
    3L(14753620-14754944)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEN34(YAR008W)4
    SEN341
    Subunit of the tRNA splicing endonuclease, which is more4
    Sen34p1
    40.34(n)1
    30.74(a)1
      1(158966-159793)4
    8512671, 4  NP_009405.11, 4 


    ENSEMBL Gene Tree for TSEN34 (if available)
    TreeFam Gene Tree for TSEN34 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 NCBI SNPs in TSEN34 are shown (see all 167    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139941501,2
    Cpathogenic53520602(+) AGGCGC/TGGCTC 4 R W mis10--------
    rs2010606091,2
    Cother53519790(+) AAGTTC/TGGAGG 4 F syn11Minor allele frequency- T:0.00EU 1323
    rs72547111,2
    C,--51008342(+) acccgA/Gactcc 1 -- us2k10--------
    rs1119582771,2
    C,--51008367(+) TGGAGG/AAGACA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs752767791,2
    C,F,--51009185(+) GGGCAG/AGGAAG 2 -- us2k11Minor allele frequency- A:0.16WA 118
    rs65098491,2
    C,F,A,--51009263(+) CCGAGC/ATNNNN 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs784351431,2
    C,--51009343(+) AGACGA/GGCTCC 2 -- us2k10--------
    rs749557451,2
    F,--51009905(+) GGGGCG/TGGACC 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs556954901,2
    --51009996(+) GGCGCA/GGTGCG 2 -- us2k1 ut510--------
    rs1152901271,2
    C,F,--51010032(+) GAATTA/GCTGTT 2 -- us2k1 ut511Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for TSEN34 (54693789 - 54698394 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TSEN34
         4 CNVs: 4088 30920 35675 3199
    Human Gene Mutation Database (HGMD): TSEN34

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSEN34
    DNA2.0 Custom Variant and Variant Library Synthesis for TSEN34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TSEN34 for disorders           About GeneDecksing

    OMIM gene information: 608754   
    OMIM disorders: 612390  
    UniProtKB/Swiss-Prot: SEN34_HUMAN, Q9BSV6
  • Defects in TSEN34 are the cause of pontocerebellar hypoplasia type 2C (PCH2C) [MIM:612390]. Pontocerebellar
  • hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem.
    PCH type 2 is characterized by progressive microcephaly from birth combined with extrapyramidal dyskinesia and chorea,
    epilepsy, and normal spinal cord findings

    6 diseases for TSEN34:    About MalaCards
    pontocerebellar hypoplasia type 2    pontocerebellar hypoplasia    pontocerebellar hypoplasia type 2c    pontocerebellar hypoplasia type 2 and type 4
    chorea    microcephaly

    1 disease from the University of Copenhagen DISEASES database for TSEN34:
    Microcephaly
    GeneTests: TSEN34
    Pontocerebellar Hypoplasia Type 2 and Type 4


    Export disorders for TSEN34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSEN34 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with TSEN34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. (PubMed id 15109492)1, 2, 3 Paushkin S.V....Trotta C.R. (2004)
    2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)1, 2, 3 Wende H.... Ziegler A. (2000)
    3. tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. (PubMed id 18711368)1, 2 Budde B.S.... Baas F. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79042 HGNC: 15506 AceView: LENG5 Ensembl:ENSG00000170892 euGenes: HUgn79042
    ECgene: TSEN34 H-InvDB: TSEN34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSEN34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSEN34 gene:
    Search GeneIP for patents involving TSEN34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TSEN34  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSEN34   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSEN34  
     OriGene Protein Over-expression Lysate for TSEN34   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TSEN34   OriGene 3'-UTR Clone for TSEN34  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN34   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN34  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSEN34   OriGene Custom Protein Services for TSEN34  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSEN34
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSEN34
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN34
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN34
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN34
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN34
     GenScript Custom Purified and Recombinant Proteins Services for TSEN34 GenScript cDNA clones with any tag delivered in your preferred vector for TSEN34
     GenScript Custom Assay Services for TSEN34 GenScript Custom Superior Antibodies Services for TSEN34
     GenScript Custom overexpressing Cell Line Services for TSEN34 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSEN34 promoter
     Search Chromatin IP Primers for TSEN34
     RT2 qPCR Primer Assay in human, mouse, rat TSEN34
     Search GNC Networks for TSEN34
     SABiosciences Custom PCR Arrays for TSEN34
     Search Tocris compounds for TSEN34
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSEN34 antibodies
     TSEN34 proteins
     TSEN34 lysates
     Search for Antibodies for TSEN34 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TSEN34
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TSEN34 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TSEN34
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN34
     SwitchGear 3'UTR luciferase reporter plasmids for TSEN34
     SwitchGear Promoter luciferase reporter plasmids for TSEN34
     ThermoFisher Antibodies for TSEN34
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN34
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSEN34 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4