Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSEN2 Gene

protein-coding   GIFtS: 55
GCID: GC03P012525

TSEN2 TRNA Splicing Endonuclease Subunit

(Previous names: tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 9

Aliases
TSEN2 TRNA Splicing Endonuclease Subunit1 2     TRNA Splicing Endonuclease 2 Homolog (SEN2, S. Cerevisiae)1
SEN22 3 5     SEN2L2
TRNA-Intron Endonuclease Sen22 3     hsSen22
EC 3.1.27.93 8     TRNA-Splicing Endonuclease Subunit Sen22
PCH2B2 5     HsSen23
TRNA Splicing Endonuclease 2 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 284221   Entrez Gene: 807462   Ensembl: ENSG000001547437   OMIM: 6087535   UniProtKB: Q8NCE03   
ORGUL members:    fRNAdb10:FR175840      
H-InvDB12:HIT000067034    
NCBI13:AF086155    
NONCODE14:n339250 n332900 n366175 n366174      
RNAdb15:HIV2632    

Export aliases for TSEN2 gene to outside databases

Previous GC identifer: GC03P012504


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSEN2 Gene:
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first
step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with
pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants
encoding different isoforms have been found for this gene.(provided by RefSeq, Feb 2009)

GeneCards Summary for TSEN2 Gene: 
TSEN2 (TSEN2 tRNA splicing endonuclease subunit) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TSEN2 include pontocerebellar hypoplasia type 2b, and tsen2-related pontocerebellar hypoplasia. GO annotations related to this gene include tRNA-intron endonuclease activity and nucleic acid binding.

UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0
Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex
responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and
3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing
2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is
invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant
structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The
tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end
processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that
the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a
yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it
retains endonucleolytic activity

Gene Wiki entry for TSEN2 Gene

fRNAdb sequence ontology for TSEN2:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for TSEN2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSEN2 gene promoter:
         Max   STAT2   STAT1beta   LyF-1   Evi-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSEN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSEN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.2   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

TSEN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSEN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012525:  view genomic region     (about GC identifiers)

Start:
12,525,931 bp from pter      End:
12,581,122 bp from pter
Size:
55,192 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TSEN2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0 (See protein sequence)
Recommended Name: tRNA-splicing endonuclease subunit Sen2  
Size: 465 amino acids; 53247 Da
Subunit: tRNA splicing endonuclease is a heterotetramer composed of isoform 1 of SEN2, SEN15, SEN34/LENG5 and
SEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such
as CLP1, CPSF1, CPSF4 and CSTF2. Isoform 2 belongs to a different complex that contains SEN54 but low level of
SEN15 and SEN34/LENG5
Subcellular location: Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus
Secondary accessions: B7Z6K1 C9IZI7 G5E9Q3 Q8WTW7 Q9BPU7
Alternative splicing: 5 isoforms:  Q8NCE0-1   Q8NCE0-2   Q8NCE0-3   Q8NCE0-4   Q8NCE0-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSEN2: NX_Q8NCE0

Explore proteomics data for TSEN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCE0

  • 4 DME Specific Peptides for TSEN2 (Q8NCE0)
     LCYLIKPS  RWVSSRERS  KGYFGKGILSRSRP  TTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASY 

    TSEN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSEN2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001138864.1  NP_001138865.1  NP_001138866.1  NP_001138867.1  NP_079541.1  

    ENSEMBL proteins: 
     ENSP00000406238   ENSP00000392029   ENSP00000385976   ENSP00000284995   ENSP00000416510  
     ENSP00000408744   ENSP00000408528   ENSP00000323188   ENSP00000373307   ENSP00000407974  

    Human Recombinant Protein Products for TSEN2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TSEN2
    OriGene Protein Over-expression Lysate for TSEN2
    OriGene MassSpec for TSEN2 
    OriGene Custom Protein Services for TSEN2
    GenScript Custom Purified and Recombinant Proteins Services for TSEN2
    Novus Biologicals TSEN2 Proteins
    Novus Biologicals TSEN2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSEN2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000214tRNA-intron endonuclease complex IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    TSEN2 for ontologies           About GeneDecksing



    TSEN2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSEN2
    GenScript Custom Superior Antibodies Services for TSEN2
    Novus Biologicals TSEN2 Antibodies
    Abcam antibodies for TSEN2
    Cloud-Clone Corp. Antibodies for TSEN2 
    Search ThermoFisher Antibodies for TSEN2
    LSBio Antibodies in human, mouse, rat for TSEN2 

    Assay Products for TSEN2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSEN2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSEN2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSEN2 
    Cloud-Clone Corp. CLIAs for TSEN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TSEN: tRNA splicing endonuclease subunits

    4 InterPro protein domains:
     IPR006678 tRNA_intron_Endonuc_N
     IPR006677 tRNA_intron_Endonuc_cat-like
     IPR011856 tRNA_endonuc-like_dom
     IPR016589 tRNA_splic_SEN2

    Graphical View of Domain Structure for InterPro Entry Q8NCE0

    ProtoNet protein and cluster: Q8NCE0

    UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0
    Similarity: Belongs to the tRNA-intron endonuclease family


    TSEN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEN2_HUMAN, Q8NCE0
    Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex
    responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and
    3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing
    2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is
    invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant
    structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The
    tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end
    processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that
    the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a
    yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it
    retains endonucleolytic activity
    Catalytic activity: Endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxy and 2',3'-cyclic phosphate termini,
    and specifically removing the intron

         Enzyme Number (IUBMB): EC 3.1.27.91 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000213tRNA-intron endonuclease activity IEA--
    GO:0003676nucleic acid binding IEA--
         
    TSEN2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSEN2:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSEN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSEN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSEN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSEN2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSEN2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TSEN2:
    hsa-miR-1255a hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidTSEN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSEN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSEN2
    Sirion Biotech Customized adenovirus for overexpression of TSEN2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TSEN2 (see all 25)
    OriGene ORF clones in mouse, rat for TSEN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): TSEN2 (NM_001145395)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSEN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN2
    Sirion Biotech Customized lentivirus for stable overexpression of TSEN2 
                         Customized lentivirus expression plasmids for stable overexpression of TSEN2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSEN2
    Search LifeMap BioReagents cell lines for TSEN2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSEN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TSEN2 (Q8NCE03 ENSP000002849954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP10Q6VN203, ENSP000003165894I2D: score=1 STRING: ENSP00000316589
    TSEN15Q8WW013, ENSP000003552994I2D: score=1 STRING: ENSP00000355299
    TSEN34Q9BSV63, ENSP000003055244I2D: score=1 STRING: ENSP00000305524
    CLP1Q929893, ENSP000003047044I2D: score=1 STRING: ENSP00000304704
    TSEN54Q7Z6J93, ENSP000003274874I2D: score=1 STRING: ENSP00000327487
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation IDA17495927
    GO:0006397mRNA processing IEA--

    TSEN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSEN2 (SEN2)

    Search CenterWatch for drugs/clinical trials and news about TSEN2 / SEN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for TSEN2 gene (5 alternative transcripts): 
    NM_001145392.1  NM_001145393.1  NM_001145394.1  NM_001145395.1  NM_025265.3  

    Unigene Cluster for TSEN2:

    TRNA splicing endonuclease 2 homolog (S. cerevisiae)
    Hs.335550  [show with all ESTs]
    Unigene Representative Sequence: AK027821
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446004 ENST00000454502(uc003bwz.3) ENST00000402228(uc003bxb.3)
    ENST00000284995(uc003bxc.3) ENST00000473755(uc011auq.1 uc011aur.1)
    ENST00000415684 ENST00000490981 ENST00000455118 ENST00000412698 ENST00000475595
    ENST00000314571(uc003bxa.3) ENST00000383797 ENST00000444864
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSEN2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TSEN2:
    hsa-miR-1255a hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidTSEN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSEN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN2
    Clone
    Products:
         
    OriGene clones in human, mouse for TSEN2 (see all 25)
    OriGene ORF clones in mouse, rat for TSEN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): TSEN2 (NM_001145395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSEN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN2
    Sirion Biotech Customized lentivirus for stable overexpression of TSEN2 
                         Customized lentivirus expression plasmids for stable overexpression of TSEN2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TSEN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSEN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN2

    Additional mRNA sequence: 

    AK027821.1 AK074794.1 AK225875.1 AK291183.1 AK295508.1 AK300449.1 BC004178.2 BC004211.2 
    BC019582.1 BC021975.2 

    13 DOTS entries:

    DT.75152559  DT.108993  DT.97780236  DT.91758864  DT.97843187  DT.40113675  DT.75184254  DT.120856517 
    DT.120856562  DT.95176751  DT.205119  DT.95094835  DT.97821396 

    24/148 AceView cDNA sequences (see all 148):

    CR612570 BQ892775 BU168893 BM796374 BX282415 BC021975 BX354978 BQ685510 
    BU185728 BQ877205 BU174665 BI253416 BQ688193 BU157366 BQ687535 BQ689456 
    BU149564 BQ877656 BU196626 BQ894877 BC004178 BQ686435 CD359061 BM970995 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TSEN2 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17
    SP1:              -     -                                               -                             -                                 
    SP2:                    -                                               -                             -                                 
    SP3:                                                              -     -                             -                                 
    SP4:        -     -     -                                                                                                               
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TSEN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSEN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSEN2 Expression
    About this image


    See TSEN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSEN2

    SOURCE GeneReport for Unigene cluster: Hs.335550

    UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0
    Tissue specificity: Isoform 1 and isoform 2 are widely expressed at very low level

        SABiosciences Custom PCR Arrays for TSEN2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TSEN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSEN2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSEN2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsen21 , 5 tRNA splicing endonuclease 2 homolog (S. cerevisiae)1, 5 74.83(n)1
    71.08(a)1
      6 (53.58 cM)5
    3818021  NM_199033.11  NP_950198.11 
     1155446645 
    chicken
    (Gallus gallus)
    Aves TSEN21 tRNA splicing endonuclease 2 homolog (S. cerevisiae) 63.82(n)
    55.26(a)
      415965  NM_001030594.1  NP_001025765.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSEN26
    Uncharacterized protein
    53(a)
    1 ↔ 1
    2(158915468-158923997)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.348942 Xenopus laevis transcribed sequence with weak similarity more 75.84(n)    BJ643700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsen21 tRNA splicing endonuclease 2 homolog (S. cerevisiae) 52.48(n)
    46.51(a)
      767713  NM_001076651.1  NP_001070119.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG318126
    --
    29(a)
    1 ↔ 1
    2L(16729778-16731199)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEN2(YLR105C)4 Subunit of the tRNA splicing endonuclease, which is more   --   12(348180-347047) 850795  NP_013206.1 


    ENSEMBL Gene Tree for TSEN2 (if available)
    TreeFam Gene Tree for TSEN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSEN2 gene
    18/78 SIMAP similar genes for TSEN2 using alignment to 4 protein entries:     SEN2_HUMAN (see all proteins) (see all similar genes):
    MEFV    UBIAD1    ERBB2    ZNF564    C4orf22    C10orf137
    HKR1    NEK4    ZNF410    FAM3A    ZNF212    ZNF880
    FAM175A    FAM210A    TNFRSF17    ZNF585B    ZNF737    APOD

    TSEN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TSEN2
    PGOHUM00000246144


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1297 SNPs in TSEN2 are shown (see all 1297)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139941491,2,4
    CPontocerebellar hypoplasia 2B (PCH2B)4 pathogenic112493271(+) GGTCTA/GTGCTC 10 Y C mis10--------
    rs2005825471,2
    C--12459207(-) AAAAAA/GGAAAA 5 -- us2k10--------
    rs1510270761,2
    C--12459229(+) TTATG-/TTTTTT 5 -- us2k10--------
    rs1927021701,2
    --12459494(+) CGGATA/TTTACA 5 -- us2k10--------
    rs1149701411,2
    --12459512(+) TTCAGC/TTGTCT 5 -- us2k10--------
    rs1849730071,2
    --12459521(+) CTCTCC/TCCTGC 5 -- us2k10--------
    rs1147838601,2
    C,F--12459758(+) TGGCTC/TAAGCC 5 -- us2k11Minor allele frequency- T:0.04WA 118
    rs7059621,2
    C,F,A,H--12459760(+) GCTCAC/AGCCTG 5 -- us2k111Minor allele frequency- A:0.45NA WA CSA EA 258
    rs7059631,2
    C,F,A,H--12459790(-) CCGCCG/TCGGCC 5 -- us2k110Minor allele frequency- T:0.37NA WA CSA 19
    rs1897505581,2
    --12459842(+) ACGTGA/GTGAAA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSEN2 (12525931 - 12581122 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TSEN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv850e199CNV Deletion23128226
    dgv810e201CNV Deletion23290073
    nsv3703CNV Insertion18451855
    nsv876541CNV Gain21882294
    esv2751977CNV Gain17911159
    nsv7351OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): TSEN2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSEN2
    DNA2.0 Custom Variant and Variant Library Synthesis for TSEN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608753OMIM information: 117360 600644 252350 601869 606658 607135 608448 608982 609299    
    OMIM disorders: 612389  
    UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0
  • Pontocerebellar hypoplasia 2B (PCH2B) [MIM:612389]: A disorder characterized by an abnormally small
    cerebellum and brainstem, and progressive microcephaly from birth combined with extrapyramidal dyskinesia. Severe
    chorea occurs and epilepsy is frequent. There are no signs of spinal cord anterior horn cells degeneration.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for TSEN2:    About MalaCards
    pontocerebellar hypoplasia type 2b    tsen2-related pontocerebellar hypoplasia    pontocerebellar hypoplasia    pontocerebellar hypoplasia type 2
    pontocerebellar hypoplasia type 2 and type 4    chorea    microcephaly

    1 disease from the University of Copenhagen DISEASES database for TSEN2:
    Microcephaly

    TSEN2 for disorders           About GeneDecksing

    GeneTests: TSEN2
    GeneReviews: TSEN2
    Genetic Association Database (GAD): TSEN2

    Export disorders for TSEN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSEN2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with TSEN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. (PubMed id 15109492)1, 2, 3 Paushkin S.V....Trotta C.R. (2004)
    2. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    7. tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. (PubMed id 18711368)2 Budde B.S.... Baas F. (2008)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs. (PubMed id 17495927)1 Weitzer S. and Martinez J. (2007)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80746 HGNC: 28422 AceView: SEN2L Ensembl:ENSG00000154743 euGenes: HUgn80746
    ECgene: TSEN2 H-InvDB: TSEN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSEN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSEN2 gene:
    Search GeneIP for patents involving TSEN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSEN2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TSEN2  
     OriGene MassSpec something-or-other for TSEN2   OriGene clones in human, mouse for TSEN2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSEN2   OriGene Purified Protein for TSEN2  
     OriGene ORF clones in mouse, rat for TSEN2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSEN2   OriGene Custom Protein Services for TSEN2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSEN2
     QIAGEN SeqTarget long-range PCR primers for resequencing TSEN2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN2
     GenScript Custom Purified and Recombinant Proteins Services for TSEN2 GenScript cDNA clones with any tag delivered in your preferred vector for TSEN2
     GenScript Custom Assay Services for TSEN2 GenScript Custom Superior Antibodies Services for TSEN2
     GenScript Custom overexpressing Cell Line Services for TSEN2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSEN2 promoter
     Search Chromatin IP Primers for TSEN2
     RT2 qPCR Primer Assay in human, mouse, rat TSEN2
     Search GNC Networks for TSEN2
     SABiosciences Custom PCR Arrays for TSEN2
     Search Tocris compounds for TSEN2 (SEN2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSEN2 antibodies
     TSEN2 proteins
     TSEN2 lysates
     Antibodies for TSEN2
     See all of Abcam's Antibodies, Kits and Proteins for TSEN2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TSEN2
     Antibodies for TSEN2
     ELISAs for TSEN2
     CLIAs for TSEN2
     Search LifeMap BioReagents cell lines for TSEN2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN2
     SwitchGear 3'UTR luciferase reporter plasmids for TSEN2
     SwitchGear Promoter luciferase reporter plasmids for TSEN2
     Search ThermoFisher Antibodies for TSEN2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TSEN2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSEN2
    Customized:
     lentivirus for stable overexpression of TSEN2
     lentivirus expression plasmids for stable overexpression of TSEN2
     adenovirus for overexpression of TSEN2
     LSBio Antibodies in human, mouse, rat for TSEN2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSEN2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4