TSEN2 Gene
protein-coding GIFtS: 53
GCID: GC03P012525
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tRNA splicing endonuclease 2 homolog (S. cerevisiae)(Previous names: tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae)...)
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Aliases
for TSEN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 4
| Aliases |
|---|
| TRNA Splicing Endonuclease 2 Homolog (S. Cerevisiae)1 2 | | MGC27761 | | SEN21 2 3 5 | | TRNA Splicing Endonuclease 2 Homolog (SEN2, S. Cerevisiae)1 | | SEN2L1 2 | | HsSen23 | | TRNA-Intron Endonuclease Sen22 3 | | TRNA-Splicing Endonuclease Subunit Sen22 | | EC 3.1.27.93 8 | | HsSen23 | | PCH2B2 5 | | |
| External Ids: | HGNC: 284221 | Entrez Gene: 807462 | Ensembl: ENSG000001547437 | OMIM: 6087535 | UniProtKB: Q8NCE03 |
|---|
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Export aliases for TSEN2 gene to outside databasesPrevious GC identifer: GC03P012504
Summaries
for TSEN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSEN2:
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step inRNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellarhypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding differentisoforms have been found for this gene.(provided by RefSeq, Feb 2009)
UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsiblefor identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites torelease the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OHtermini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same sitein the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is alsoinvolved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link betweenpre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multipleRNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containingisoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity
Gene Wiki entry for TSEN2
fRNAdb sequence ontology for TSEN2:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
View fRNAdb secondary structures for TSEN2 |
Genomic Views
for TSEN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSEN2 gene promoter:
Max STAT2 STAT1beta LyF-1 Evi-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSEN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25.2 Ensembl cytogenetic band: 3p25.2 HGNC cytogenetic band: 3p25.2TSEN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P012525: view genomic region
(about GC identifiers)
Start:
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12,525,931 bp from pter |
End:
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12,581,122 bp from pter |
Size:
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55,192 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
12548552 12564842 12581132 chr3
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Proteins
for TSEN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0 (See
protein sequence)Recommended Name: tRNA-splicing endonuclease subunit Sen2 Size: 465 amino acids; 53247 Da
Subunit: tRNA splicing endonuclease is a heterotetramer composed of isoform 1 of SEN2, SEN15, SEN34/LENG5 and SEN54.tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1,CPSF1, CPSF4 and CSTF2. Isoform 2 belongs to a different complex that contains SEN54 but low level of SEN15 andSEN34/LENG5
Subcellular location: Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus
Secondary accessions: B7Z6K1 C9IZI7 G5E9Q3 Q8WTW7 Q9BPU7Alternative splicing: 5 isoforms: Q8NCE0-1 Q8NCE0-2 Q8NCE0-3 Q8NCE0-4 Q8NCE0-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TSEN2: NX_Q8NCE0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCE0
4 DME Specific Peptides for TSEN2 (Q8NCE0)
TSEN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001138864.1 NP_001138865.1 NP_001138866.1 NP_001138867.1 NP_079541.1
ENSEMBL proteins: ENSP00000406238 ENSP00000392029 ENSP00000385976 ENSP00000284995 ENSP00000416510 ENSP00000408744 ENSP00000408528 ENSP00000323188 ENSP00000373307 ENSP00000440958 ENSP00000407974
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TSEN2 for ontologies About GeneDecksing
TSEN2 Antibody Products:
Assay Products for TSEN2: |
Protein
Domains /
Families
for TSEN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSEN2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NCE0ProtoNet protein and cluster: Q8NCE0 UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0Similarity: Belongs to the tRNA-intron endonuclease family |
Function
for TSEN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0Function: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsiblefor identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites torelease the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OHtermini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same sitein the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is alsoinvolved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link betweenpre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multipleRNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containingisoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activityCatalytic activity: Endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxy and 2',3'-cyclic phosphate termini, andspecifically removing the intronEnzyme Number (IUBMB): EC 3.1.27.91 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN2 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): TSEN2 (NM_001145395) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSEN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000213 | tRNA-intron endonuclease activity |
IEA | -- | | GO:0003676 | nucleic acid binding |
IEA | -- |
TSEN2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TSEN2:
|
Pathways & Interactions
for TSEN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSEN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for TSEN2 (Q8NCE03 ENSP000002849954) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation |
IDA | 17495927 | | GO:0006397 | mRNA processing |
IEA | -- |
TSEN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSEN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSEN2
Search CenterWatch for drugs/clinical trials and news about TSEN2 / SEN2
|
Transcripts
for TSEN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
| 1 fRNAdb Secondary structure:
REFSEQ mRNAs for TSEN2 gene (5 alternative transcripts): NM_001145392.1 NM_001145393.1 NM_001145394.1 NM_001145395.1 NM_025265.3 Unigene Cluster for TSEN2: TRNA splicing endonuclease 2 homolog (S. cerevisiae) Hs.335550 [show with all ESTs]Unigene Representative Sequence: AK02782114 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446004 ENST00000454502(uc003bwz.3) ENST00000402228(uc003bxb.3)
ENST00000284995(uc003bxc.3) ENST00000473755(uc011auq.1 uc011aur.1)
ENST00000415684 ENST00000490981 ENST00000455118 ENST00000412698 ENST00000475595
ENST00000314571(uc003bxa.3) ENST00000383797 ENST00000537959 ENST00000444864
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN2 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): TSEN2 (NM_001145395) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSEN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN2 |
Additional cDNA sequence: AK027821.1 AK074794.1 AK225875.1 AK291183.1 AK295508.1 AK300449.1 BC004178.2 BC004211.2 BC019582.1 BC021975.2 13 DOTS entries: DT.75152559 DT.108993 DT.97780236 DT.91758864 DT.97843187 DT.40113675 DT.75184254 DT.120856517 DT.120856562 DT.95176751 DT.205119 DT.95094835 DT.97821396 24/148 AceView cDNA sequences (see all 148): BI253416 BU196626 BM970995 BX282415 BQ686435 BM796374 BQ689490 AI702609 BQ688193 BQ689961 BQ894877 BQ892775 BQ688855 AL537929 BC004178 BQ877205 BX332182 CR611882 BC021975 BC004211 BI489700 BU185854 BX104919 BX354978
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TSEN2 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSEN2
|
Expression
for TSEN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSEN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSEN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSEN2
SOURCE GeneReport for Unigene cluster: Hs.335550
UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0Tissue specificity: Isoform 1 and isoform 2 are widely expressed at very low level
SABiosciences Custom PCR Arrays for TSEN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSEN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSEN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN2 |
Orthologs
for TSEN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSEN2 gene from 8/22 species (see all 22) About this table
ENSEMBL Gene Tree for TSEN2 (if available)
TreeFam Gene Tree for TSEN2 (if available) |
Paralogs
for TSEN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSEN2 gene
18/66 SIMAP similar genes for TSEN2 using alignment to 5 protein entries: SEN2_HUMAN (see all proteins)
(see all similar genes):MEFV ERBB2 ZNF564 C4orf22 C10orf137 HKR1
NEK4 ZNF410 FAM3A ZNF212 ZNF880 FAM175A
FAM210A TNFRSF17 ZNF585B APOD LYRM4 NSRP1
TSEN2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSEN2
PGOHUM00000246144
|
Genomic Variants
for TSEN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSEN2 (12525931 - 12581122 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TSEN2
1 CNV: 8414
1 Inversion: 37239
Human Gene Mutation Database (HGMD): TSEN2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSEN2 |
|
Disorders
/ Diseases
for TSEN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSEN2 for disorders About GeneDecksing
OMIM gene information: 608753 117360 600644 252350 601869 606658 607135 608448 608982 609299
OMIM disorders: 612389
UniProtKB/Swiss-Prot: SEN2_HUMAN, Q8NCE0
Defects in TSEN2 are the cause of pontocerebellar hypoplasia type 2B (PCH2B) [MIM:612389]. Pontocerebellarhypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem.PCH type 2 is characterized by progressive microcephaly from birth combined with extrapyramidal dyskinesia and chorea,epilepsy, and normal spinal cord findings
6  diseases for TSEN2: About MalaCardspontocerebellar hypoplasia type 2 pontocerebellar hypoplasia pontocerebellar hypoplasia type 2b pontocerebellar hypoplasia type 2 and type 4
chorea microcephaly
1 disease from the University of Copenhagen DISEASES database for TSEN2:Microcephaly GeneTests: TSEN2
Pontocerebellar Hypoplasia Type 2 and Type 4
Export disorders for TSEN2 gene to outside databases
|
Publications
for TSEN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSEN2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with TSEN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. (PubMed id 15109492)1, 2, 3 Paushkin S.V....Trotta C.R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. (PubMed id 18711368)2 Budde B.S.... Baas F. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs. (PubMed id 17495927)1 Weitzer S. and Martinez J. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for TSEN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSEN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSEN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSEN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSEN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSEN2 gene:
Search GeneIP for patents involving TSEN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSEN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSEN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSEN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSEN2 | | | OriGene Protein Over-expression Lysate for TSEN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSEN2 | | OriGene 3'-UTR Clone for TSEN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSEN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSEN2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSEN2 | | OriGene Custom Protein Services for TSEN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSEN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSEN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN2 |
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| | | | Search Tocris compounds for TSEN2 |
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 | | | TSEN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSEN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN2 |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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