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TSEN15 Gene

protein-coding   GIFtS: 53
GCID: GC01P184020

TSEN15 TRNA Splicing Endonuclease Subunit

(Previous names: chromosome 1 open reading frame 19, tRNA splicing endonuclease...)
(Previous symbol: C1orf19)
  See TSEN15-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TSEN15 TRNA Splicing Endonuclease Subunit1 2     hsSen152
C1orf191 2 3     sen152
SEN15 Homolog2 3     TRNA Splicing Endonuclease 15 Homolog2
TRNA-Intron Endonuclease Sen152 3     TRNA-Splicing Endonuclease Subunit Sen152
Chromosome 1 Open Reading Frame 191     HsSEN153
TRNA Splicing Endonuclease 15 Homolog (S. Cerevisiae)1     SEN153

External Ids:    HGNC: 167911   Entrez Gene: 1164612   Ensembl: ENSG000001988607   OMIM: 6087565   UniProtKB: Q8WW013   

Export aliases for TSEN15 gene to outside databases

Previous GC identifers: GC01P182288 GC01P155256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSEN15 Gene:
tRNA splicing is a fundamental process required for cell growth and division. SEN15 is a subunit of the tRNA
splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al.,
2004 (PubMed 15109492)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TSEN15 Gene:
TSEN15 (TSEN15 tRNA splicing endonuclease subunit) is a protein-coding gene. Diseases associated with TSEN15 include bartter disease. GO annotations related to this gene include tRNA-intron endonuclease activity.

UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01
Function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for
identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to
release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and
5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the
same site in the gene, placing the splice sites an invariant distance from the constant structural features of
the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with
pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation,
suggesting that the endonuclease subunits function in multiple RNA-processing events

Gene Wiki entry for TSEN15 (C1orf19) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSEN15 gene promoter:
         AP-2rep   HFH-3   Nkx2-5   POU6F1 (c2)   E4BP4   FOXI1   FOXC1   HFH-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSEN15 promoter sequence
   Search Chromatin IP Primers for TSEN15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSEN15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

TSEN15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSEN15 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P184020:  view genomic region     (about GC identifiers)

Start:
184,020,811 bp from pter      End:
184,043,346 bp from pter
Size:
22,536 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01 (See protein sequence)
Recommended Name: tRNA-splicing endonuclease subunit Sen15  
Size: 171 amino acids; 18641 Da
Subunit: Homodimer. tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34/LENG5 and SEN54.
tRNA splicing endonuclease complex also contains proteins of the Pre-mRNA 3' end processing machinery such as
CLP1, CPSF1, CPSF4 and CSTF2
Caution: Although only weakly related to the S.cerevisiae SEN15 protein, it probably displays the same function
within the tRNA splicing endonuclease complex
Sequence caution: Sequence=AAG60614.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TSEN15:
2GW6 (3D)    
Secondary accessions: B4DKP0 Q9BZQ5
Alternative splicing: 2 isoforms:  Q8WW01-1   Q8WW01-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSEN15: NX_Q8WW01

Explore proteomics data for TSEN15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSEN15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120866.1  NP_443197.1  

    ENSEMBL proteins: 
     ENSP00000355299   ENSP00000435144   ENSP00000436996   ENSP00000402002   ENSP00000432397  

    TSEN15 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSEN: tRNA splicing endonuclease subunits

    2 InterPro protein domains:
     IPR018593 tRNA-endonuc_su_Sen15
     IPR006677 tRNA_intron_Endonuc_cat-like

    Graphical View of Domain Structure for InterPro Entry Q8WW01

    ProtoNet protein and cluster: Q8WW01

    UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01
    Similarity: Belongs to the SEN15 family


    Find genes that share domains with TSEN15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEN15_HUMAN, Q8WW01
    Function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for
    identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to
    release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and
    5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the
    same site in the gene, placing the splice sites an invariant distance from the constant structural features of
    the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with
    pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation,
    suggesting that the endonuclease subunits function in multiple RNA-processing events

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000213tRNA-intron endonuclease activity IEA--
         
    Find genes that share ontologies with TSEN15           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSEN15
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    miRNA
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    miRTarBase miRNAs that target TSEN15:
    hsa-mir-186-5p (MIRT044997), hsa-let-7b-5p (MIRT052033)

    Block miRNA regulation of human, mouse, rat TSEN15 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TSEN15:
    hsa-miR-548g hsa-miR-4251 hsa-miR-616* hsa-miR-340 hsa-miR-2113 hsa-miR-371-5p hsa-miR-373* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTSEN15 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEN15_HUMAN, Q8WW01: Nucleus (Probable). Nucleus, nucleolus (Probable). Note=May be transiently localized in the
    nucleolus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--

    Find genes that share ontologies with TSEN15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSEN15
    Interactions:

        Search GeneGlobe Interaction Network for TSEN15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TSEN15 (Q8WW012, 3 ENSP000003552994) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO4P619682, 3MINT-60892 I2D: score=3 
    TSEN34Q9BSV63, ENSP000003055244I2D: score=2 STRING: ENSP00000305524
    EXOSC4Q9NPD33, ENSP000003154764I2D: score=2 STRING: ENSP00000315476
    CLP1Q929893, ENSP000003047044I2D: score=1 STRING: ENSP00000304704
    TSEN2Q8NCE03, ENSP000002849954I2D: score=1 STRING: ENSP00000284995
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation IEA--
    GO:0006397mRNA processing IEA--

    Find genes that share ontologies with TSEN15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSEN15 (SEN15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSEN15 gene (2 alternative transcripts): 
    NM_001127394.2  NM_052965.2  

    Unigene Cluster for TSEN15:

    TRNA splicing endonuclease 15 homolog (S. cerevisiae)
    Hs.548197  [show with all ESTs]
    Unigene Representative Sequence: NR_023349
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361641(uc009wyg.3 uc001gqt.4 uc001gqu.4) ENST00000485209
    ENST00000533373 ENST00000367518 ENST00000423085 ENST00000462677 ENST00000457455

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TSEN15:
    hsa-miR-548g hsa-miR-4251 hsa-miR-616* hsa-miR-340 hsa-miR-2113 hsa-miR-371-5p hsa-miR-373* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTSEN15 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TSEN15 (NM_052965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSEN15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN15
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TSEN15
      QuantiFast Probe-based Assays in human, mouse, rat TSEN15

    Additional mRNA sequence: 

    AF288394.1 AK098196.1 AK296655.1 AK307241.1 BC022030.1 NR_023349.1 

    11 DOTS entries:

    DT.208943  DT.443301  DT.97858804  DT.95082653  DT.100789785  DT.100035818  DT.100789786  DT.40128007 
    DT.100035815  DT.443299  DT.101964593 

    Selected AceView cDNA sequences (see all 186):

    BQ431703 CN479379 BX336323 AW137283 BE669473 BU622552 BQ051617 BF433006 
    AI141865 BQ000295 BQ889887 AI740520 BU753543 AI247944 CA429134 AI524582 
    BF433153 AW249949 BU166129 AA905567 BQ717822 AI198454 AV718329 AI280009 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TSEN15 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                                        -     -                       -     -                                       
    SP2:                                                  -     -     -                       -     -                                       
    SP3:                                                  -     -     -           -     -     -     -                                       
    SP4:                                                  -     -     -                             -                                       
    SP5:                                                  -           -                                                                     


    ECgene alternative splicing isoforms for TSEN15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSEN15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAATAA
    TSEN15 Expression
    About this image


    TSEN15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    TSEN15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSEN15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.548197

    UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01
    Tissue specificity: Widely expressed. Highly expressed in testis and uterus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TSEN15 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsen151 , 5 tRNA splicing endonuclease 15 homolog (S. cerevisiae)1, 5 87.9(n)1
    91.07(a)1
      1 (64.75 cM)5
    666371  NM_025677.31  NP_079953.21 
     1523707355 
    chicken
    (Gallus gallus)
    Aves TSEN151 tRNA splicing endonuclease 15 homolog (S. cerevisiae) 66.14(n)
    60.32(a)
      424448  XM_422291.4  XP_422291.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tsen151 TSEN15 tRNA splicing endonuclease subunit 59.47(n)
    53.6(a)
      100124883  NM_001102835.1  NP_001096305.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tsen151 tRNA splicing endonuclease 15 homolog (S. cerevisiae) 51.39(n)
    48.33(a)
      100005064  NM_001100090.1  NP_001093560.1 


    ENSEMBL Gene Tree for TSEN15 (if available)
    TreeFam Gene Tree for TSEN15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSEN15 gene
    1 SIMAP similar gene for TSEN15 using alignment to 4 protein entries:     SEN15_HUMAN (see all proteins):
    C1orf19

    Find genes that share paralogs with TSEN15           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for TSEN15
    PGOHUM00000237247 PGOHUM00000244717 PGOHUM00000232622


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSEN15 (see all 507)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs666658561,2
    C--155272840(+) AAAAA-/AT/T  
            
    TATAT
    3 -- int11NA 2
    rs1481345101,2
    --184018931(+) ACTAGC/TAAATG 3 -- us2k1 int10--------
    rs1419312011,2
    --184018957(+) TTGGGA/GAAATT 3 -- us2k1 int10--------
    rs66710631,2
    C--184018968(+) ctggcC/Taccac 3 -- us2k1 int10--------
    rs716943721,2
    C--184018974(+) ACCAC-/TCTT  
            
    TCTTC
    3 -- us2k1 int11Minor allele frequency- TCTT:0.50CSA 2
    rs1999008541,2
    C--184018977(-) GAAGAA/GAGAGT 3 -- us2k1 int10--------
    rs1885157061,2
    --184019033(+) TGCATA/GTTGGA 3 -- us2k1 int10--------
    rs792309241,2
    C,F--184019034(+) GCATGC/TTGGAT 3 -- us2k1 int11Minor allele frequency- T:0.50WA 2
    rs1929410011,2
    --184019154(+) TTTTTA/CTTTTG 3 -- us2k1 int10--------
    rs127598371,2
    C--184019184(+) aattcA/Gcccag 3 -- us2k1 int15Minor allele frequency- G:0.09NA WA EA 362

    HapMap Linkage Disequilibrium report for TSEN15 (184020811 - 184043346 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSEN15: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSEN15
    DNA2.0 Custom Variant and Variant Library Synthesis for TSEN15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608756    OMIM disorders: --

    1 disease for TSEN15:    
    About MalaCards
    bartter disease

    1 disease from the University of Copenhagen DISEASES database for TSEN15:
    Bartter disease

    Find genes that share disorders with TSEN15           About GenesLikeMe

    Genetic Association Database (GAD): TSEN15
    Human Genome Epidemiology (HuGE) Navigator: TSEN15 (1 document)

    Export disorders for TSEN15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSEN15 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TSEN15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold. (PubMed id 17166513)1, 2, 3, 9 Song J. and Markley J.L. (J. Mol. Biol. 2007)
    2. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3 Sood R....Carpten J.D. (Genomics 2001)
    3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. (PubMed id 15109492)1, 2 Paushkin S.V.... Trotta C.R. (Cell 2004)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116461 HGNC: 16791 AceView: C1orf19 Ensembl:ENSG00000198860 euGenes: HUgn116461
    ECgene: TSEN15 H-InvDB: TSEN15

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TSEN15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TSEN15 gene:
    Search GeneIP for patents involving TSEN15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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