Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSEN15 Gene

protein-coding   GIFtS: 54
GCID: GC01P184020

TSEN15 TRNA Splicing Endonuclease Subunit

(Previous names: chromosome 1 open reading frame 19, tRNA splicing endonuclease...)
(Previous symbol: C1orf19)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TSEN15 TRNA Splicing Endonuclease Subunit1 2     hsSen152
C1orf191 2 3     sen152
SEN15 Homolog2 3     TRNA Splicing Endonuclease 15 Homolog2
TRNA-Intron Endonuclease Sen152 3     TRNA-Splicing Endonuclease Subunit Sen152
Chromosome 1 Open Reading Frame 191     HsSEN153
TRNA Splicing Endonuclease 15 Homolog (S. Cerevisiae)1     SEN153

External Ids:    HGNC: 167911   Entrez Gene: 1164612   Ensembl: ENSG000001988607   OMIM: 6087565   UniProtKB: Q8WW013   
ORGUL members:         
NONCODE14:n406458      

Export aliases for TSEN15 gene to outside databases

Previous GC identifers: GC01P182288 GC01P155256


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSEN15 Gene:
tRNA splicing is a fundamental process required for cell growth and division. SEN15 is a subunit of the tRNA
splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al.,
2004 (PubMed 15109492)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TSEN15 Gene: 
TSEN15 (TSEN15 tRNA splicing endonuclease subunit) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TSEN15 include bartter disease, and intrahepatic cholangiocarcinoma.

UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01
Function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for
identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to
release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and
5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the
same site in the gene, placing the splice sites an invariant distance from the constant structural features of
the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with
pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation,
suggesting that the endonuclease subunits function in multiple RNA-processing events

Gene Wiki entry for TSEN15 (C1orf19) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSEN15 gene promoter:
         AP-2rep   HFH-3   Nkx2-5   POU6F1 (c2)   E4BP4   FOXI1   FOXC1   HFH-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSEN15 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSEN15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

TSEN15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSEN15 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P184020:  view genomic region     (about GC identifiers)

Start:
184,020,811 bp from pter      End:
184,043,346 bp from pter
Size:
22,536 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01 (See protein sequence)
Recommended Name: tRNA-splicing endonuclease subunit Sen15  
Size: 171 amino acids; 18641 Da
Subunit: Homodimer. tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34/LENG5 and SEN54.
tRNA splicing endonuclease complex also contains proteins of the Pre-mRNA 3' end processing machinery such as
CLP1, CPSF1, CPSF4 and CSTF2
Subcellular location: Nucleus (Probable). Nucleus, nucleolus (Probable). Note=May be transiently localized in the
nucleolus (Probable)
Caution: Although only weakly related to the S.cerevisiae SEN15 protein, it probably displays the same function
within the tRNA splicing endonuclease complex
Sequence caution: Sequence=AAG60614.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TSEN15:
2GW6 (3D)    
Secondary accessions: B4DKP0 Q9BZQ5
Alternative splicing: 2 isoforms:  Q8WW01-1   Q8WW01-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSEN15: NX_Q8WW01

Explore proteomics data for TSEN15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WW01

  • TSEN15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSEN15 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001120866.1  NP_443197.1  

    ENSEMBL proteins: 
     ENSP00000355299   ENSP00000435144   ENSP00000436996   ENSP00000402002   ENSP00000432397  

    Human Recombinant Protein Products for TSEN15: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TSEN15
    OriGene Protein Over-expression Lysate for TSEN15
    OriGene MassSpec for TSEN15 
    OriGene Custom Protein Services for TSEN15
    GenScript Custom Purified and Recombinant Proteins Services for TSEN15
    Novus Biologicals TSEN15 Proteins
    Novus Biologicals TSEN15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TSEN15
    Cloud-Clone Corp. Proteins for TSEN15 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--

    TSEN15 for ontologies           About GeneDecksing



    TSEN15 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSEN15
    GenScript Custom Superior Antibodies Services for TSEN15
    Novus Biologicals TSEN15 Antibodies
    Abcam antibodies for TSEN15
    Cloud-Clone Corp. Antibodies for TSEN15 
    Search ThermoFisher Antibodies for TSEN15
    LSBio Antibodies in human, mouse, rat for TSEN15 

    Assay Products for TSEN15: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSEN15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSEN15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSEN15 
    Cloud-Clone Corp. CLIAs for TSEN15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TSEN: tRNA splicing endonuclease subunits

    1 InterPro protein domain:
     IPR024369 tRNA-intron_endonuclease_Sen15

    Graphical View of Domain Structure for InterPro Entry Q8WW01

    ProtoNet protein and cluster: Q8WW01

    UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01
    Similarity: Belongs to the SEN15 family


    TSEN15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEN15_HUMAN, Q8WW01
    Function: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for
    identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to
    release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and
    5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the
    same site in the gene, placing the splice sites an invariant distance from the constant structural features of
    the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with
    pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation,
    suggesting that the endonuclease subunits function in multiple RNA-processing events

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000213tRNA-intron endonuclease activity IEA--
         
    TSEN15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSEN15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSEN15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSEN15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSEN15 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSEN15
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TSEN15:
    hsa-miR-548g hsa-miR-4251 hsa-miR-616* hsa-miR-340 hsa-miR-2113 hsa-miR-371-5p hsa-miR-373* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTSEN15 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSEN15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSEN15
    Sirion Biotech Customized adenovirus for overexpression of TSEN15

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TSEN15 (see all 11)
    OriGene ORF clones in mouse, rat for TSEN15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TSEN15 (NM_052965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSEN15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN15
    Sirion Biotech Customized lentivirus for stable overexpression of TSEN15 
                         Customized lentivirus expression plasmids for stable overexpression of TSEN15 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSEN15
    Search LifeMap BioReagents cell lines for TSEN15
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSEN15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for TSEN15 (Q8WW012, 3 ENSP000003552994) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO4P619682, 3MINT-60892 I2D: score=3 
    TSEN34Q9BSV63, ENSP000003055244I2D: score=2 STRING: ENSP00000305524
    EXOSC4Q9NPD33, ENSP000003154764I2D: score=2 STRING: ENSP00000315476
    CLP1Q929893, ENSP000003047044I2D: score=1 STRING: ENSP00000304704
    TSEN2Q8NCE03, ENSP000002849954I2D: score=1 STRING: ENSP00000284995
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation IEA--
    GO:0006397mRNA processing IEA--
    GO:0008033tRNA processing ----

    TSEN15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSEN15 (SEN15)

    Search CenterWatch for drugs/clinical trials and news about TSEN15 / SEN15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSEN15 gene (2 alternative transcripts): 
    NM_001127394.2  NM_052965.2  

    Unigene Cluster for TSEN15:

    TRNA splicing endonuclease 15 homolog (S. cerevisiae)
    Hs.548197  [show with all ESTs]
    Unigene Representative Sequence: NR_023349
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361641(uc009wyg.3 uc001gqt.4 uc001gqu.4) ENST00000485209
    ENST00000533373 ENST00000367518 ENST00000423085 ENST00000462677 ENST00000457455

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSEN15
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TSEN15:
    hsa-miR-548g hsa-miR-4251 hsa-miR-616* hsa-miR-340 hsa-miR-2113 hsa-miR-371-5p hsa-miR-373* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTSEN15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TSEN15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN15
    Clone
    Products:
         
    OriGene clones in human, mouse for TSEN15 (see all 11)
    OriGene ORF clones in mouse, rat for TSEN15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TSEN15 (NM_052965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSEN15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN15
    Sirion Biotech Customized lentivirus for stable overexpression of TSEN15 
                         Customized lentivirus expression plasmids for stable overexpression of TSEN15 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TSEN15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSEN15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN15

    Additional mRNA sequence: 

    AF288394.1 AK098196.1 AK296655.1 AK307241.1 BC022030.1 NR_023349.1 

    11 DOTS entries:

    DT.208943  DT.443301  DT.97858804  DT.95082653  DT.100789785  DT.100035818  DT.100789786  DT.40128007 
    DT.100035815  DT.443299  DT.101964593 

    24/186 AceView cDNA sequences (see all 186):

    AA701990 AA194112 BI821111 AI356051 AI740520 AA992577 AI188760 BU677196 
    AI280009 BF476359 AF288394 AI198454 AI418101 BE669473 AL522412 AW087228 
    AA905567 AI720184 BF433153 BQ431703 BF109586 BE670994 BQ717822 CB158796 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TSEN15 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                                        -     -                       -     -                                       
    SP2:                                                  -     -     -                       -     -                                       
    SP3:                                                  -     -     -           -     -     -     -                                       
    SP4:                                                  -     -     -                             -                                       
    SP5:                                                  -           -                                                                     


    ECgene alternative splicing isoforms for TSEN15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSEN15 expression in normal human tissues (normalized intensities)      TSEN15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAATAA
    TSEN15 Expression
    About this image


    TSEN15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer

    See TSEN15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSEN15

    SOURCE GeneReport for Unigene cluster: Hs.548197

    UniProtKB/Swiss-Prot: SEN15_HUMAN, Q8WW01
    Tissue specificity: Widely expressed. Highly expressed in testis and uterus

        SABiosciences Custom PCR Arrays for TSEN15
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TSEN15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSEN15
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN15
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TSEN15 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsen151 , 5 tRNA splicing endonuclease 15 homolog (S. cerevisiae)1, 5 88.49(n)1
    92.86(a)1
      1 (64.75 cM)5
    666371  NM_025677.31  NP_079953.21 
     1523707355 
    chicken
    (Gallus gallus)
    Aves TSEN151 tRNA splicing endonuclease 15 homolog (S. cerevisiae) 62.85(n)
    56.69(a)
      424448  XM_003641664.1  XP_003641712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsen151 tRNA splicing endonuclease 15 homolog (S. cerevisiae) 51.39(n)
    48.33(a)
      100005064  NM_001100090.1  NP_001093560.1 


    ENSEMBL Gene Tree for TSEN15 (if available)
    TreeFam Gene Tree for TSEN15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSEN15 gene
    1 SIMAP similar gene for TSEN15 using alignment to 4 protein entries:     SEN15_HUMAN (see all proteins):
    C1orf19

    TSEN15 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for TSEN15
    PGOHUM00000237247 PGOHUM00000244717 PGOHUM00000232622


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/507 SNPs in TSEN15 are shown (see all 507)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs666658561,2
    C--155272840(+) AAAAA-/AT/T  
            
    TATAT
    3 -- int11NA 2
    rs1481345101,2
    --184018931(+) ACTAGC/TAAATG 3 -- us2k1 int10--------
    rs1419312011,2
    --184018957(+) TTGGGA/GAAATT 3 -- us2k1 int10--------
    rs66710631,2
    C--184018968(+) ctggcC/Taccac 3 -- us2k1 int10--------
    rs716943721,2
    C--184018974(+) ACCAC-/TCTT  
            
    TCTTC
    3 -- us2k1 int11Minor allele frequency- TCTT:0.50CSA 2
    rs1999008541,2
    C--184018977(-) GAAGAA/GAGAGT 3 -- us2k1 int10--------
    rs1885157061,2
    --184019033(+) TGCATA/GTTGGA 3 -- us2k1 int10--------
    rs792309241,2
    C,F--184019034(+) GCATGC/TTGGAT 3 -- us2k1 int11Minor allele frequency- T:0.50WA 2
    rs1929410011,2
    --184019154(+) TTTTTA/CTTTTG 3 -- us2k1 int10--------
    rs127598371,2
    C--184019184(+) aattcA/Gcccag 3 -- us2k1 int15Minor allele frequency- G:0.09NA WA EA 362

    HapMap Linkage Disequilibrium report for TSEN15 (184020811 - 184043346 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSEN15: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSEN15
    DNA2.0 Custom Variant and Variant Library Synthesis for TSEN15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608756    OMIM disorders: --

    6 diseases for TSEN15:    About MalaCards
    bartter disease    intrahepatic cholangiocarcinoma    cholangiocarcinoma    prostate cancer
    prostatitis    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for TSEN15:
    Bartter disease

    TSEN15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSEN15
    Human Genome Epidemiology (HuGE) Navigator: TSEN15 (1 document)

    Export disorders for TSEN15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSEN15 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TSEN15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold. (PubMed id 17166513)1, 2, 3, 9 Song J. and Markley J.L. (2007)
    2. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3 Sood R....Carpten J.D. (2001)
    3. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. (PubMed id 15109492)1, 2 Paushkin S.V....Trotta C.R. (2004)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116461 HGNC: 16791 AceView: C1orf19 Ensembl:ENSG00000198860 euGenes: HUgn116461
    ECgene: TSEN15 H-InvDB: TSEN15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSEN15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSEN15 gene:
    Search GeneIP for patents involving TSEN15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSEN15  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TSEN15  
     OriGene MassSpec something-or-other for TSEN15   OriGene clones in human, mouse for TSEN15  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSEN15   OriGene Purified Protein for TSEN15  
     OriGene ORF clones in mouse, rat for TSEN15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSEN15   OriGene Custom Protein Services for TSEN15  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSEN15
     QIAGEN SeqTarget long-range PCR primers for resequencing TSEN15
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSEN15
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSEN15
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSEN15
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSEN15
     GenScript Custom Purified and Recombinant Proteins Services for TSEN15 GenScript cDNA clones with any tag delivered in your preferred vector for TSEN15
     GenScript Custom Assay Services for TSEN15 GenScript Custom Superior Antibodies Services for TSEN15
     GenScript Custom overexpressing Cell Line Services for TSEN15 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TSEN15 promoter
     Search Chromatin IP Primers for TSEN15
     RT2 qPCR Primer Assay in human, mouse, rat TSEN15
     Search GNC Networks for TSEN15
     SABiosciences Custom PCR Arrays for TSEN15
     Search Tocris compounds for TSEN15 (SEN15)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TSEN15 antibodies
     TSEN15 proteins
     TSEN15 lysates
     Antibodies for TSEN15
     See all of Abcam's Antibodies, Kits and Proteins for TSEN15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TSEN15




     Proteins for TSEN15
     Antibodies for TSEN15
     ELISAs for TSEN15
     CLIAs for TSEN15
     Search LifeMap BioReagents cell lines for TSEN15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSEN15
     SwitchGear 3'UTR luciferase reporter plasmids for TSEN15
     SwitchGear Promoter luciferase reporter plasmids for TSEN15
     Search ThermoFisher Antibodies for TSEN15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSEN15
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TSEN15
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSEN15
    Customized:
     lentivirus for stable overexpression of TSEN15
     lentivirus expression plasmids for stable overexpression of TSEN15
     adenovirus for overexpression of TSEN15
     LSBio Antibodies in human, mouse, rat for TSEN15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSEN15 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4