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Aliases for TSC22D4 Gene

Aliases for TSC22D4 Gene

  • TSC22 Domain Family Member 4 2 3 5
  • TSC22-Related-Inducible Leucine Zipper Protein 2 3 4
  • Tsc-22-Like Protein THG-1 3 4
  • TILZ2 3 4
  • THG1 3 4
  • TSC22 Domain Family, Member 4 2
  • TSC22 Domain Family Protein 4 3
  • THG-1 3

External Ids for TSC22D4 Gene

Previous GeneCards Identifiers for TSC22D4 Gene

  • GC07M099709
  • GC07M099902
  • GC07M100060
  • GC07M094697

Summaries for TSC22D4 Gene

Entrez Gene Summary for TSC22D4 Gene

  • TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TSC22D4 Gene

TSC22D4 (TSC22 Domain Family Member 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TSC22D2.

UniProtKB/Swiss-Prot for TSC22D4 Gene

  • Transcriptional repressor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D4 Gene

Genomics for TSC22D4 Gene

Regulatory Elements for TSC22D4 Gene

Enhancers for TSC22D4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100538 2 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -65.3 -65335 12.6 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SAP25 PILRA IRS3P FBXO24 LRCH4 NYAP1 TSC22D4 C7orf61 ZSCAN25 PCOLCE
GH07G100438 1.7 FANTOM5 Ensembl ENCODE 12.5 +36.5 36457 8.0 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 PILRA C7orf61 TSC22D4 NYAP1 IRS3P SAP25 FBXO24 LRCH4 GPC2 PVRIG
GH07G100450 1.3 Ensembl ENCODE 12.7 +28.6 28551 1.5 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZSCAN25 ZNF655 GIGYF1 STAG3L5P ENSG00000242798 MEPCE AP4M1 PPP1R35 TSC22D4 NYAP1
GH07G100560 1.3 ENCODE dbSUPER 12.1 -80.8 -80824 0.1 HDGF PKNOX1 ARNT ARID4B DMAP1 YBX1 ZNF143 FOS PAF1 SP5 NYAP1 TSC22D4 C7orf61 IRS3P AGFG2
GH07G100559 1.3 ENCODE dbSUPER 12.1 -80.7 -80664 0.2 HDGF FOXA2 PKNOX1 ARNT SIN3A ARID4B DMAP1 ZNF2 ZNF143 FOS NYAP1 TSC22D4 C7orf61 IRS3P AGFG2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSC22D4 on UCSC Golden Path with GeneCards custom track

Promoters for TSC22D4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215799 779 2201 HDGF PKNOX1 FOXA2 ARNT AGO1 ZFP64 WRNIP1 SIN3A ARID4B FEZF1

Genomic Location for TSC22D4 Gene

Chromosome:
7
Start:
100,463,359 bp from pter
End:
100,479,279 bp from pter
Size:
15,921 bases
Orientation:
Minus strand

Genomic View for TSC22D4 Gene

Genes around TSC22D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSC22D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSC22D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D4 Gene

Proteins for TSC22D4 Gene

  • Protein details for TSC22D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3Q8-T22D4_HUMAN
    Recommended name:
    TSC22 domain family protein 4
    Protein Accession:
    Q9Y3Q8
    Secondary Accessions:
    • A4D2C3
    • A8MWR6
    • D6W5V9

    Protein attributes for TSC22D4 Gene

    Size:
    395 amino acids
    Molecular mass:
    41026 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1.

    Alternative splice isoforms for TSC22D4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSC22D4 Gene

Post-translational modifications for TSC22D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSC22D4 Gene

No data available for DME Specific Peptides for TSC22D4 Gene

Domains & Families for TSC22D4 Gene

Protein Domains for TSC22D4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TSC22D4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3Q8

UniProtKB/Swiss-Prot:

T22D4_HUMAN :
  • Belongs to the TSC-22/Dip/Bun family.
Family:
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D4: view

No data available for Gene Families for TSC22D4 Gene

Function for TSC22D4 Gene

Molecular function for TSC22D4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TSC22D4: view
genes like me logo Genes that share phenotypes with TSC22D4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSC22D4 Gene

Localization for TSC22D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSC22D4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSC22D4 gene
Compartment Confidence
nucleus 4
cytosol 4

Gene Ontology (GO) - Cellular Components for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSC22D4: view

Pathways & Interactions for TSC22D4 Gene

SuperPathways for TSC22D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated NAS 10488076
GO:0070236 negative regulation of activation-induced cell death of T cells IBA --
genes like me logo Genes that share ontologies with TSC22D4: view

No data available for Pathways by source and SIGNOR curated interactions for TSC22D4 Gene

Transcripts for TSC22D4 Gene

Unigene Clusters for TSC22D4 Gene

TSC22 domain family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: -
SP8: -

Relevant External Links for TSC22D4 Gene

GeneLoc Exon Structure for
TSC22D4
ECgene alternative splicing isoforms for
TSC22D4

Expression for TSC22D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSC22D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSC22D4 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for TSC22D4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3) and NK cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSC22D4 Gene



Protein tissue co-expression partners for TSC22D4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSC22D4 Gene:

TSC22D4

SOURCE GeneReport for Unigene cluster for TSC22D4 Gene:

Hs.469798

Evidence on tissue expression from TISSUES for TSC22D4 Gene

  • Skin(4.4)
  • Blood(4.2)
  • Lung(4.2)
  • Liver(4.1)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with TSC22D4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSC22D4 Gene

Orthologs for TSC22D4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSC22D4 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia TSC22D4 34 35
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Tsc22d4 34
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Tsc22d4 34 16 35
  • 84.93 (n)
cow
(Bos Taurus)
Mammalia TSC22D4 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSC22D4 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 8 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii TSC22D4 35
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bun 35
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30G4.7 35
  • 34 (a)
ManyToMany
T18D3.7 35
  • 26 (a)
ManyToMany
Species where no ortholog for TSC22D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSC22D4 Gene

ENSEMBL:
Gene Tree for TSC22D4 (if available)
TreeFam:
Gene Tree for TSC22D4 (if available)

Paralogs for TSC22D4 Gene

Paralogs for TSC22D4 Gene

(3) SIMAP similar genes for TSC22D4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSC22D4: view

Variants for TSC22D4 Gene

Sequence variations from dbSNP and Humsavar for TSC22D4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036284 A breast cancer sample
rs1000076772 -- 100,468,996(+) TGAGG(A/C)GAGTG intron-variant
rs1000131233 -- 100,474,997(+) GGTCT(C/G)AAGAT intron-variant
rs1000423470 -- 100,474,864(+) TGGCA(A/C)AATCA intron-variant
rs1000500983 -- 100,477,085(+) AACAG(C/G)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSC22D4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv518432 CNV loss 19592680
nsv527050 CNV loss 19592680
nsv527107 CNV loss 19592680
nsv831071 CNV loss 17160897
nsv951385 CNV deletion 24416366

Variation tolerance for TSC22D4 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSC22D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSC22D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSC22D4 Gene

Disorders for TSC22D4 Gene

Relevant External Links for TSC22D4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSC22D4

No disorders were found for TSC22D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSC22D4 Gene

Publications for TSC22D4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. (PMID: 10488076) Kester H.A. … van der Burg B. (J. Biol. Chem. 1999) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for TSC22D4 Gene

Sources for TSC22D4 Gene

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