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Aliases for TSC22D4 Gene

Aliases for TSC22D4 Gene

  • TSC22 Domain Family, Member 4 2 3
  • THG1 3 4 6
  • TSC22-Related-Inducible Leucine Zipper Protein 2 3 4
  • Tsc-22-Like Protein THG-1 3 4
  • TILZ2 3 4
  • TSC22 Domain Family Protein 4 3
  • THG-1 3

External Ids for TSC22D4 Gene

Previous GeneCards Identifiers for TSC22D4 Gene

  • GC07M099709
  • GC07M099902
  • GC07M100060
  • GC07M094697

Summaries for TSC22D4 Gene

Entrez Gene Summary for TSC22D4 Gene

  • TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TSC22D4 Gene

TSC22D4 (TSC22 Domain Family, Member 4) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TSC22D2.

UniProtKB/Swiss-Prot for TSC22D4 Gene

  • Transcriptional repressor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D4 Gene

Genomics for TSC22D4 Gene

Regulatory Elements for TSC22D4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSC22D4 Gene

100,463,359 bp from pter
100,479,279 bp from pter
15,921 bases
Minus strand

Genomic View for TSC22D4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSC22D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D4 Gene

Proteins for TSC22D4 Gene

  • Protein details for TSC22D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TSC22 domain family protein 4
    Protein Accession:
    Secondary Accessions:
    • A4D2C3
    • A8MWR6
    • D6W5V9

    Protein attributes for TSC22D4 Gene

    395 amino acids
    Molecular mass:
    41026 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1

    Alternative splice isoforms for TSC22D4 Gene


neXtProt entry for TSC22D4 Gene

Proteomics data for TSC22D4 Gene at MOPED

Post-translational modifications for TSC22D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSC22D4 Gene

Antibody Products

No data available for DME Specific Peptides for TSC22D4 Gene

Domains for TSC22D4 Gene

Protein Domains for TSC22D4 Gene


Suggested Antigen Peptide Sequences for TSC22D4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y3Q8
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D4: view

No data available for Gene Families for TSC22D4 Gene

Function for TSC22D4 Gene

Molecular function for TSC22D4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor

Gene Ontology (GO) - Molecular Function for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TSC22D4: view

Animal Model Products

miRNA for TSC22D4 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSC22D4 Gene

Localization for TSC22D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSC22D4 Gene

Subcellular locations from

Jensen Localization Image for TSC22D4 Gene COMPARTMENTS Subcellular localization image for TSC22D4 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with TSC22D4: view

Pathways for TSC22D4 Gene

SuperPathways for TSC22D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006970 response to osmotic stress --
GO:0045892 negative regulation of transcription, DNA-templated NAS 10488076
genes like me logo Genes that share ontologies with TSC22D4: view

No data available for Pathways by source for TSC22D4 Gene

Transcripts for TSC22D4 Gene

Unigene Clusters for TSC22D4 Gene

TSC22 domain family, member 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSC22D4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP7: -
SP8: -

Relevant External Links for TSC22D4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSC22D4 Gene

mRNA expression in normal human tissues for TSC22D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSC22D4 Gene

This gene is overexpressed in Whole Blood (4.2).

Protein differential expression in normal tissues for TSC22D4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3) and NK cells (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSC22D4 Gene

SOURCE GeneReport for Unigene cluster for TSC22D4 Gene Hs.469798

genes like me logo Genes that share expressions with TSC22D4: view

Expression partners for TSC22D4 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSC22D4 Gene

Orthologs for TSC22D4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TSC22D4 35
  • 88.1 (n)
  • 87.59 (a)
TSC22D4 36
  • 59 (a)
(Mus musculus)
Mammalia Tsc22d4 35
  • 84.93 (n)
  • 86.3 (a)
Tsc22d4 16
Tsc22d4 36
  • 56 (a)
(Pan troglodytes)
Mammalia TSC22D4 35
  • 99.49 (n)
  • 99.24 (a)
TSC22D4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tsc22d4 35
  • 85.27 (n)
  • 87.08 (a)
(Bos Taurus)
Mammalia TSC22D4 36
  • 70 (a)
(Monodelphis domestica)
Mammalia TSC22D4 36
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 8 (a)
(Danio rerio)
Actinopterygii TSC22D4 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta bun 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea C30G4.7 36
  • 34 (a)
T18D3.7 36
  • 26 (a)
Species with no ortholog for TSC22D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSC22D4 Gene

Gene Tree for TSC22D4 (if available)
Gene Tree for TSC22D4 (if available)

Paralogs for TSC22D4 Gene

Paralogs for TSC22D4 Gene

Selected SIMAP similar genes for TSC22D4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSC22D4: view

Variants for TSC22D4 Gene

Sequence variations from dbSNP and Humsavar for TSC22D4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11512 -- 100,466,570(+) AACCT(G/T)AATCC utr-variant-3-prime
rs1132386 -- 100,466,962(-) TCCGT(C/T)TGAGC reference, synonymous-codon
rs1132441 -- 100,466,723(-) AACCC(A/C)CACCC utr-variant-3-prime
rs1137783 -- 100,473,906(-) ggcac(A/G)gtggc intron-variant
rs1962268 -- 100,475,149(-) ccaag(A/T)tcacg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSC22D4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831071 CNV Loss 17160897
nsv527107 CNV Loss 19592680
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
nsv518432 CNV Loss 19592680
nsv527050 CNV Loss 19592680
nsv888781 CNV Loss 21882294
nsv888783 CNV Loss 21882294
nsv888784 CNV Loss 21882294

Relevant External Links for TSC22D4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSC22D4 Gene

Disorders for TSC22D4 Gene

(1) University of Copenhagen DISEASES for TSC22D4 Gene

genes like me logo Genes that share disorders with TSC22D4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for TSC22D4 Gene

Publications for TSC22D4 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. (PMID: 10488076) Kester H.A. … van der Burg B. (J. Biol. Chem. 1999) 3 4
  4. Expression screening for Lhx3 downstream genes identifies Thg-1pit as a novel mouse gene involved in pituitary development. (PMID: 11707329) Fiorenza M.T. … Westphal H. (Gene 2001) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TSC22D4 Gene

Sources for TSC22D4 Gene

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