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TSC22D4 Gene

protein-coding   GIFtS: 51
GCID: GC07M100060

TSC22 Domain Family, Member 4

  Search for TSC22D4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TSC22 Domain Family, Member 41 2     TSC22-Related-Inducible Leucine Zipper Protein 22 3
THG12 3 5     THG-12
Tsc-22-Like Protein THG-12 3     TSC22 Domain Family 42
TILZ22 3     TSC22 Domain Family Protein 42

External Ids:    HGNC: 216961   Entrez Gene: 816282   Ensembl: ENSG000001669257   OMIM: 6119145   UniProtKB: Q9Y3Q83   

Export aliases for TSC22D4 gene to outside databases

Previous GC identifers: GC07M099709 GC07M099902 GC07M094697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSC22D4 Gene:
TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM
300506) (Kester et al., 1999 (PubMed 10488076); Fiorenza et al., 2001 (PubMed 11707329)).(supplied by OMIM, Mar
2008)

GeneCards Summary for TSC22D4 Gene:
TSC22D4 (TSC22 domain family, member 4) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TSC22D3.

UniProtKB/Swiss-Prot: T22D4_HUMAN, Q9Y3Q8
Function: Transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSC22D4 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sp1   E2F-2   YY1   E47   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TSC22D4 promoter sequence
   Search Chromatin IP Primers for TSC22D4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSC22D4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21-p15   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7p21-p15

TSC22D4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSC22D4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100060:  view genomic region     (about GC identifiers)

Start:
100,060,982 bp from pter      End:
100,076,902 bp from pter
Size:
15,921 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,424,226-99,436,987     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T22D4_HUMAN, Q9Y3Q8 (See protein sequence)
Recommended Name: TSC22 domain family protein 4  
Size: 395 amino acids; 41026 Da
Subunit: Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1
Secondary accessions: A4D2C3 D6W5V9

Explore the universe of human proteins at neXtProt for TSC22D4: NX_Q9Y3Q8

Explore proteomics data for TSC22D4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSC22D4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112197.1  
    ENSEMBL proteins: 
     ENSP00000300181   ENSP00000388168   ENSP00000377560   ENSP00000395795  

    TSC22D4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TSC22D4
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    Novus Biologicals TSC22D4 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSC22D4

     
    Search eBioscience for Proteins for TSC22D4 

    TSC22D4 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TSC22D4

    TSC22D4 Assay Products:

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    Cloud-Clone Corp. ELISAs for TSC22D4
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    Search eBioscience for ELISAs for TSC22D4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000580 TSC-22_Dip_Bun

    Graphical View of Domain Structure for InterPro Entry Q9Y3Q8

    ProtoNet protein and cluster: Q9Y3Q8

    1 Blocks protein domain: IPB000580 TSC-22 / Dip / Bun family

    UniProtKB/Swiss-Prot: T22D4_HUMAN, Q9Y3Q8
    Similarity: Belongs to the TSC-22/Dip/Bun family


    Find genes that share domains with TSC22D4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T22D4_HUMAN, Q9Y3Q8
    Function: Transcriptional repressor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with TSC22D4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSC22D4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSC22D4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSC22D4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSC22D4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSC22D4:
    hsa-mir-455-3p (MIRT037825), hsa-mir-22-3p (MIRT030651), hsa-mir-7-5p (MIRT025708), hsa-mir-124-3p (MIRT004100)

    Block miRNA regulation of human, mouse, rat TSC22D4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSC22D4 (see all 19):
    hsa-miR-320a hsa-miR-331-3p hsa-miR-1260b hsa-miR-944 hsa-miR-346 hsa-miR-1297 hsa-miR-124 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidTSC22D4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSC22D4
    Predesigned siRNA for gene silencing in human, mouse, rat TSC22D4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TSC22D4

    Clone
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    OriGene clones in human, mouse for TSC22D4 (see all 7)
    OriGene ORF clones in mouse, rat for TSC22D4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSC22D4 (NM_030935)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSC22D4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TSC22D4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T22D4_HUMAN, Q9Y3Q8: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with TSC22D4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSC22D4
    Interactions:

        Search GeneGlobe Interaction Network for TSC22D4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TSC22D4 (Q9Y3Q81, 2, 3 ENSP000003001814) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZMYND10O758001, 2, 3, ENSP000002317494EBI-739485,EBI-747061 MINT-66981 I2D: score=6 STRING: ENSP00000231749
    NRBP1Q9UHY12, 3, ENSP000002335574MINT-67585 I2D: score=6 STRING: ENSP00000233557
    CCNKO759092, 3, ENSP000003745294MINT-66119 I2D: score=5 STRING: ENSP00000374529
    CDC23Q9UJX22, 3, ENSP000003783504MINT-67439 I2D: score=5 STRING: ENSP00000378350
    FXR2P511162, 3, ENSP000002501134MINT-67443 I2D: score=5 STRING: ENSP00000250113
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006970response to osmotic stress IEA--
    GO:0045892negative regulation of transcription, DNA-templated NAS10488076

    Find genes that share ontologies with TSC22D4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSC22D4 (T22D4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSC22D4 gene: 
    NM_030935.3  

    Unigene Cluster for TSC22D4:

    TSC22 domain family, member 4
    Hs.469798  [show with all ESTs]
    Unigene Representative Sequence: NM_030935
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496728 ENST00000300181(uc003uva.3 uc011kjv.2 uc010lgx.3)
    ENST00000423266 ENST00000393991 ENST00000456330 ENST00000493217(uc003uvc.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSC22D4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSC22D4 (see all 19):
    hsa-miR-320a hsa-miR-331-3p hsa-miR-1260b hsa-miR-944 hsa-miR-346 hsa-miR-1297 hsa-miR-124 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidTSC22D4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSC22D4
    Predesigned siRNA for gene silencing in human, mouse, rat TSC22D4
    Clone
    Products:
         
    OriGene clones in human, mouse for TSC22D4 (see all 7)
    OriGene ORF clones in mouse, rat for TSC22D4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSC22D4 (NM_030935)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSC22D4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSC22D4
    OriGene qSTAR qPCR primer pairs in human, mouse for TSC22D4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSC22D4
      QuantiTect SYBR Green Assays in human, mouse, rat TSC22D4
      QuantiFast Probe-based Assays in human, mouse, rat TSC22D4

    Additional mRNA sequence: 

    AJ133115.1 AK296580.1 AK297702.1 AK310800.1 AK314824.1 BC001486.2 BC001966.1 BC002972.1 
    BC010406.2 BC011974.1 BC031622.1 

    16 DOTS entries:

    DT.115225  DT.91753677  DT.91753702  DT.100651302  DT.121124226  DT.100651300  DT.102827085  DT.91967431 
    DT.121124229  DT.91793234  DT.101974815  DT.121124189  DT.121124193  DT.91708964  DT.95306620  DT.95327062 

    Selected AceView cDNA sequences (see all 355):

    BQ221916 AW028300 AW474276 CR600230 CR595620 AW148991 AI360926 CA424090 
    AI923855 T34080 AI869604 BF222817 AW194400 AA300675 BU957185 BM920408 
    BF110010 AW198227 BE882265 NM_001004323 BF110003 AI869974 BM695102 AI933069 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                -     -     -     -                 -     -                           
    SP2:                                -     -     -     -                 -     -                           
    SP3:                                                                    -     -                           
    SP4:                                                                          -                           
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TSC22D4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSC22D4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCGGTCC
    TSC22D4 Expression
    About this image


    TSC22D4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    TSC22D4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSC22D4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469798
        Custom PCR Arrays for TSC22D4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSC22D4
    QuantiTect SYBR Green Assays in human, mouse, rat TSC22D4
    QuantiFast Probe-based Assays in human, mouse, rat TSC22D4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSC22D4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsc22d41 , 5 TSC22 domain family, member 41, 5 84.93(n)1
    86.3(a)1
      5 (76.64 cM)5
    788291  NM_023910.61  NP_076399.41 
     1377457305 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    8(a)
    many ↔ many
    GL343395.1(575209-578359)
    zebrafish
    (Danio rerio)
    Actinopterygii TSC22D46
    TSC22 domain family, member 4
    26(a)
    1 ↔ 1
    20(54848858-54888082) ENSDARG00000068912
    fruit fly
    (Drosophila melanogaster)
    Insecta bun6
    bunched
    9(a)
    1 → many
    2L(12455540-12546630)
    worm
    (Caenorhabditis elegans)
    Secernentea C30G4.76
    T18D3.76
    Protein C30G4.7 (C30G4.7) mRNA, complete cds
    Protein T18D3.7, isoform a (T18D3.7) mRNA, complet...
    34(a)
    26(a)
    many ↔ many
    many ↔ many
    X(17056927-17058536) WBGene00016272
    X(12434154-12443915) WBGene00011824


    ENSEMBL Gene Tree for TSC22D4 (if available)
    TreeFam Gene Tree for TSC22D4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSC22D4 gene
    TSC22D32  TSC22D12  TSC22D22  
    3 SIMAP similar genes for TSC22D4 using alignment to 5 protein entries:     T22D4_HUMAN (see all proteins):
    TSC22D2    TSC22D3    TSC22D1

    Find genes that share paralogs with TSC22D4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSC22D4 (see all 274)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362844
    A breast cancer sample4--see VAR_0362842 V M mis40--------
    rs114532251,2
    C--100063919(+) CCCAG-/TCCCCC 1 -- int10--------
    rs341624631,2
    C--100063920(+) CCAGC-/TCCCCC 1 -- int10--------
    rs799894371,2
    C--100064028(+) TCCTCC/TGTCTC 1 -- int10--------
    rs1854540391,2
    --100064115(+) CACAAG/TCAACG 1 -- int10--------
    rs115591211,2
    C,F,H--100064494(+) GACACG/AGGGAC 1 -- ut31 ese35Minor allele frequency- A:0.01NS 848
    rs1817970621,2
    --100064529(+) GCAGGC/TGGCTG 1 -- ut310--------
    rs1999944631,2
    --100064590(+) GACGGA/GGGGCC 2 P S mis10--------
    rs2018961231,2
    --100064609(+) GCAGGA/GGGCCC 2 P syn10--------
    rs346662771,2
    C,F--100064620(-) TCCCAC/TGGCTT 2 R W mis12Minor allele frequency- T:0.02NA EU 255

    HapMap Linkage Disequilibrium report for TSC22D4 (100060982 - 100076902 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TSC22D4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    dgv7398n71CNV Loss21882294
    nsv527107CNV Loss19592680
    nsv518432CNV Loss19592680
    nsv831071CNV Loss17160897
    nsv888783CNV Loss21882294
    nsv527050CNV Loss19592680
    nsv888784CNV Loss21882294
    nsv888779CNV Loss21882294
    nsv888781CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TSC22D4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611914    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TSC22D4:
    Hypobetalipoproteinemia

    Find genes that share disorders with TSC22D4           About GenesLikeMe


    Export disorders for TSC22D4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSC22D4 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TSC22D4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    3. Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. (PubMed id 10488076)1, 2 Kester H.A....van der Burg B. (J. Biol. Chem. 1999)
    4. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. (PubMed id 23382044)1 Hast B.E....Major M.B. (Cancer Res. 2013)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. (PubMed id 20149264)1 Gluderer S....Stocker H. (J. Biol. 2010)
    9. tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'- 3' DNA polymerases. (PubMed id 21059936)1 Hyde S.J.... Doublie S. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81628 HGNC: 21696 AceView: THG-1andMGC43036 Ensembl:ENSG00000166925 euGenes: HUgn81628
    ECgene: TSC22D4 H-InvDB: TSC22D4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSC22D4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSC22D4 gene:
    Search GeneIP for patents involving TSC22D4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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