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Aliases for TSC22D4 Gene

Aliases for TSC22D4 Gene

  • TSC22 Domain Family Member 4 2 3 5
  • TSC22-Related-Inducible Leucine Zipper Protein 2 3 4
  • TSC22 Domain Family, Member 4 2 3
  • Tsc-22-Like Protein THG-1 3 4
  • TILZ2 3 4
  • THG1 3 4
  • THG-1 3

External Ids for TSC22D4 Gene

Previous GeneCards Identifiers for TSC22D4 Gene

  • GC07M099709
  • GC07M099902
  • GC07M100060
  • GC07M094697

Summaries for TSC22D4 Gene

Entrez Gene Summary for TSC22D4 Gene

  • TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TSC22D4 Gene

TSC22D4 (TSC22 Domain Family Member 4) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TSC22D2.

UniProtKB/Swiss-Prot for TSC22D4 Gene

  • Transcriptional repressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D4 Gene

Genomics for TSC22D4 Gene

Regulatory Elements for TSC22D4 Gene

Promoters for TSC22D4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSC22D4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSC22D4 Gene

Chromosome:
7
Start:
100,463,359 bp from pter
End:
100,479,279 bp from pter
Size:
15,921 bases
Orientation:
Minus strand

Genomic View for TSC22D4 Gene

Genes around TSC22D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSC22D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSC22D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D4 Gene

Proteins for TSC22D4 Gene

  • Protein details for TSC22D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3Q8-T22D4_HUMAN
    Recommended name:
    TSC22 domain family protein 4
    Protein Accession:
    Q9Y3Q8
    Secondary Accessions:
    • A4D2C3
    • A8MWR6
    • D6W5V9

    Protein attributes for TSC22D4 Gene

    Size:
    395 amino acids
    Molecular mass:
    41026 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1.

    Alternative splice isoforms for TSC22D4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSC22D4 Gene

Proteomics data for TSC22D4 Gene at MOPED

Post-translational modifications for TSC22D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSC22D4 Gene

Antibody Products

No data available for DME Specific Peptides for TSC22D4 Gene

Domains & Families for TSC22D4 Gene

Protein Domains for TSC22D4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TSC22D4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3Q8

UniProtKB/Swiss-Prot:

T22D4_HUMAN :
  • Belongs to the TSC-22/Dip/Bun family.
Family:
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D4: view

No data available for Gene Families for TSC22D4 Gene

Function for TSC22D4 Gene

Molecular function for TSC22D4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TSC22D4: view
genes like me logo Genes that share phenotypes with TSC22D4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSC22D4 Gene

Localization for TSC22D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSC22D4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSC22D4 Gene COMPARTMENTS Subcellular localization image for TSC22D4 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TSC22D4 Gene

Pathways & Interactions for TSC22D4 Gene

SuperPathways for TSC22D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSC22D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated NAS 10488076
genes like me logo Genes that share ontologies with TSC22D4: view

No data available for Pathways by source and SIGNOR curated interactions for TSC22D4 Gene

Drugs & Compounds for TSC22D4 Gene

No Compound Related Data Available

Transcripts for TSC22D4 Gene

Unigene Clusters for TSC22D4 Gene

TSC22 domain family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: -
SP8: -

Relevant External Links for TSC22D4 Gene

GeneLoc Exon Structure for
TSC22D4
ECgene alternative splicing isoforms for
TSC22D4

Expression for TSC22D4 Gene

mRNA expression in normal human tissues for TSC22D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSC22D4 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for TSC22D4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3) and NK cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSC22D4 Gene



SOURCE GeneReport for Unigene cluster for TSC22D4 Gene Hs.469798

genes like me logo Genes that share expression patterns with TSC22D4: view

Protein tissue co-expression partners for TSC22D4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TSC22D4 Gene

Orthologs for TSC22D4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSC22D4 35
  • 99.49 (n)
  • 99.24 (a)
TSC22D4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSC22D4 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSC22D4 36
  • 59 (a)
OneToOne
TSC22D4 35
  • 88.1 (n)
  • 87.59 (a)
mouse
(Mus musculus)
Mammalia Tsc22d4 16
Tsc22d4 36
  • 56 (a)
OneToOne
Tsc22d4 35
  • 84.93 (n)
  • 86.3 (a)
oppossum
(Monodelphis domestica)
Mammalia TSC22D4 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsc22d4 35
  • 85.27 (n)
  • 87.08 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 8 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii TSC22D4 36
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bun 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30G4.7 36
  • 34 (a)
ManyToMany
T18D3.7 36
  • 26 (a)
ManyToMany
Species with no ortholog for TSC22D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSC22D4 Gene

ENSEMBL:
Gene Tree for TSC22D4 (if available)
TreeFam:
Gene Tree for TSC22D4 (if available)

Paralogs for TSC22D4 Gene

Paralogs for TSC22D4 Gene

(3) SIMAP similar genes for TSC22D4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSC22D4: view

Variants for TSC22D4 Gene

Sequence variations from dbSNP and Humsavar for TSC22D4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036284 A breast cancer sample
rs11512 -- 100,466,570(+) AACCT(G/T)AATCC nc-transcript-variant, utr-variant-3-prime
rs1137783 -- 100,473,906(+) ggcac(A/C/G/T)gtggc intron-variant
rs2897360 -- 100,473,768(-) AAAAA(A/T)ATATA intron-variant
rs4321923 -- 100,480,786(+) GGGAC(C/G)ACAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSC22D4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831071 CNV Loss 17160897
nsv527107 CNV Loss 19592680
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
nsv518432 CNV Loss 19592680
nsv527050 CNV Loss 19592680
nsv888781 CNV Loss 21882294
nsv888783 CNV Loss 21882294
nsv888784 CNV Loss 21882294

Variation tolerance for TSC22D4 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSC22D4 Gene

HapMap Linkage Disequilibrium report
TSC22D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSC22D4 Gene

Disorders for TSC22D4 Gene

Relevant External Links for TSC22D4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSC22D4

No disorders were found for TSC22D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSC22D4 Gene

Publications for TSC22D4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. (PMID: 23382044) Hast B.E. … Major M.B. (Cancer Res. 2013) 3

Products for TSC22D4 Gene

Sources for TSC22D4 Gene

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