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TSC22D3 Gene

protein-coding   GIFtS: 55
GCID: GC0XM106956

TSC22 Domain Family, Member 3

(Previous names: delta sleep inducing peptide, immunoreactor)
(Previous symbol: DSIPI)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TSC22 Domain Family, Member 31 2     TSC-22-Like Protein2 3
DSIPI1 2 3 5     TSC-22-Related Protein2 3
GILZ2 3 5     Glucocorticoid-Induced Leucine Zipper1
Delta Sleep Inducing Peptide, Immunoreactor1 2     DIP2
Delta Sleep-Inducing Peptide Immunoreactor2 3     DSIP-Immunoreactive Leucine Zipper Protein2
Glucocorticoid-Induced Leucine Zipper Protein2 3     TSC-22 Related Protein2
TSC-22R2 3     TSC22 Domain Family Protein 32
DSIP-Immunoreactive Peptide2 3     Protein DIP3
hDIP2 3     

External Ids:    HGNC: 30511   Entrez Gene: 18312   Ensembl: ENSG000001575147   OMIM: 3005065   UniProtKB: Q995763   

Export aliases for TSC22D3 gene to outside databases

Previous GC identifers: GC0XM106763 GC0XM096580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSC22D3 Gene:
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs,
both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this
gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the
anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding
different isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSC22D3 Gene:
TSC22D3 (TSC22 domain family, member 3) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and MRF binding. An important paralog of this gene is TSC22D1.

UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576
Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional
activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in
the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits
anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By
similarity)

Gene Wiki entry for TSC22D3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSC22D3 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TSC22D3 promoter sequence
   Search Chromatin IP Primers for TSC22D3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSC22D3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

TSC22D3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSC22D3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM106956:  view genomic region     (about GC identifiers)

Start:
106,956,451 bp from pter      End:
107,020,572 bp from pter
Size:
64,122 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576 (See protein sequence)
Recommended Name: TSC22 domain family protein 3  
Size: 134 amino acids; 14810 Da
Subunit: Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity).
Interacts with NFKB1
Sequence caution: Sequence=AAH18148.3; Type=Erroneous initiation; Sequence=CAA90644.1; Type=Erroneous initiation;
Sequence=CAB53669.1; Type=Frameshift; Positions=4;
Secondary accessions: Q5H9S3 Q5JRI9 Q6FIH6 Q8NAI1 Q8WVB9 Q9UBN5 Q9UG13
Alternative splicing: 3 isoforms:  Q99576-1   Q99576-3   Q99576-4   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSC22D3: NX_Q99576

Explore proteomics data for TSC22D3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSC22D3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001015881.1  NP_004080.2  NP_932174.1  

    ENSEMBL proteins: 
     ENSP00000361466   ENSP00000361474   ENSP00000314655   ENSP00000361458   ENSP00000361459  
     ENSP00000361457   ENSP00000427427   ENSP00000421016   ENSP00000425414   ENSP00000422060  
     ENSP00000427199   ENSP00000425155   ENSP00000422636   ENSP00000424653   ENSP00000427075  
     ENSP00000425158   ENSP00000422228  
    Reactome Protein details: Q99576

    TSC22D3 Human Recombinant Protein Products:

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    Novus Biologicals TSC22D3 Proteins
    Novus Biologicals TSC22D3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TSC22D3
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TSC22D3 

     
    antibodies-online proteins for TSC22D3 (14 products) 

     
    antibodies-online peptides for TSC22D3

    TSC22D3 Antibody Products:

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    ThermoFisher Antibodies for TSC22D3
    antibodies-online antibodies for TSC22D3 (63 products) 

    TSC22D3 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TSC22D3 
    antibodies-online kits for TSC22D3 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000580 TSC-22_Dip_Bun

    Graphical View of Domain Structure for InterPro Entry Q99576

    ProtoNet protein and cluster: Q99576

    1 Blocks protein domain: IPB000580 TSC-22 / Dip / Bun family

    UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576
    Domain: The leucine-zipper is involved in homodimerization (By similarity)
    Similarity: Belongs to the TSC-22/Dip/Bun family


    Find genes that share domains with TSC22D3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T22D3_HUMAN, Q99576
    Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional
    activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in
    the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits
    anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By
    similarity)
    Induction: By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in
    monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043426MRF binding IEA--
         
    Find genes that share ontologies with TSC22D3           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tsc22d3):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  no phenotypic analysis 
     reproductive system 

    Find genes that share phenotypes with TSC22D3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tsc22d3tm1.1Ric for TSC22D3

       genOway: Develop your customized and physiologically relevant rodent model for TSC22D3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TSC22D3:
    hsa-mir-335-5p (MIRT018941), hsa-mir-182-5p (MIRT005359), hsa-mir-19b-3p (MIRT050637), hsa-mir-484 (MIRT042293), hsa-mir-744-5p (MIRT037722), hsa-mir-18a-5p (MIRT004547), hsa-mir-1229-3p (MIRT036322), hsa-mir-124-3p (MIRT004548), hsa-mir-877-3p (MIRT037102)

    Block miRNA regulation of human, mouse, rat TSC22D3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSC22D3 (see all 68):
    hsa-miR-124* hsa-miR-4254 hsa-miR-15a hsa-miR-192* hsa-miR-3690 hsa-miR-186* hsa-miR-324-3p hsa-miR-4255
    SwitchGear 3'UTR luciferase reporter plasmidTSC22D3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TSC22D3
    Predesigned siRNA for gene silencing in human, mouse, rat TSC22D3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): TSC22D3 (NM_004089)
    Sino Biological Human cDNA Clone for TSC22D3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSC22D3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TSC22D3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TSC22D3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSC22D3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with TSC22D3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TSC22D3
        Stimuli-sensing channels


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TSC22D3: 
              Apoptosis 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TSC22D3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TSC22D3 (Q995763 ENSP000003614584) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HPCAL4Q9UM193, ENSP000003619354I2D: score=4 STRING: ENSP00000361935
    PLEKHF2Q9H8W43, ENSP000003223734I2D: score=4 STRING: ENSP00000322373
    JUNP054123, ENSP000003602664I2D: score=3 STRING: ENSP00000360266
    NFKB1P198383, ENSP000002265744I2D: score=3 STRING: ENSP00000226574
    NFKB2Q006533, ENSP000001894444I2D: score=3 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-templated TAS8982256
    GO:0006970response to osmotic stress IEA--
    GO:0007589body fluid secretion IEA--
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with TSC22D3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSC22D3 (T22D3)

    Selected Novoseek inferred chemical compound relationships for TSC22D3 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dsip 97.9 30 1285360 (1), 8581045 (1), 16637289 (1), 8175965 (1) (see all 28)
    leucine 49.7 12 19875485 (2), 20018851 (2), 15755904 (1), 19275887 (1) (see all 9)
    dexamethasone 39.4 9 16243713 (3), 16293609 (2), 19875485 (1), 19880449 (1)
    acth 17 2 1285360 (1), 7698722 (1)
    arginine 11.2 2 1285360 (1), 1709331 (1)
    gaba 9.2 2 12881986 (1), 7895296 (1)
    sodium 0 5 16720863 (3), 19275887 (1), 16216878 (1)
    lipid 0 2 9448709 (2)
    steroid 0 1 8237103 (1)
    calcium 0 1 8688518 (1)



    Find genes that share compounds with TSC22D3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSC22D3 gene (3 alternative transcripts): 
    NM_001015881.1  NM_004089.3  NM_198057.2  

    Unigene Cluster for TSC22D3:

    TSC22 domain family, member 3
    Hs.522074  [show with all ESTs]
    Unigene Representative Sequence: NM_198057
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372390(uc004enf.3) ENST00000372397(uc004eng.3) ENST00000315660(uc004eni.3 uc004enj.3)
    ENST00000372383(uc004enh.3) ENST00000372384 ENST00000372382 ENST00000506081
    ENST00000514426 ENST00000486554 ENST00000503515 ENST00000514897 ENST00000480691
    ENST00000510887 ENST00000502650 ENST00000506724 ENST00000505965 ENST00000502961

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    Selected qRT-PCR Assays for microRNAs that regulate TSC22D3 (see all 68):
    hsa-miR-124* hsa-miR-4254 hsa-miR-15a hsa-miR-192* hsa-miR-3690 hsa-miR-186* hsa-miR-324-3p hsa-miR-4255
    SwitchGear 3'UTR luciferase reporter plasmidTSC22D3 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TSC22D3
      QuantiFast Probe-based Assays in human, mouse, rat TSC22D3

    Additional mRNA sequence: 

    AB025432.1 AF153603.1 AF183393.1 AF228339.1 AK092645.1 AK092669.1 AK127938.1 AK300535.1 
    AK311834.1 AL110191.1 AY007119.1 BC018148.1 BC072446.1 BX647854.1 CR533450.1 CR933650.1 
    Z50781.1 

    Selected DOTS entries (see all 28):

    DT.449448  DT.100768326  DT.100845476  DT.121287702  DT.87079224  DT.75191253  DT.121287741  DT.100845470 
    DT.100845466  DT.121287753  DT.309972  DT.95262380  DT.97847872  DT.95262390  DT.95262394  DT.97847870 
    DT.100845472  DT.121287760  DT.92450428  DT.100690726  DT.100707359  DT.100845463  DT.100845465  DT.100845471 

    Selected AceView cDNA sequences (see all 655):

    AA833692 AI480119 BU687370 CD722936 BM686936 CR622973 AA293176 BQ576207 
    BF171453 NM_004089 BU733300 W92333 BM465086 AA775091 BQ787316 BM995469 
    AI089512 BU659785 BM510971 BU786060 BQ083822 AA427718 AA318908 AI368808 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D3 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:                    -     -     -     -     -           -     -     -     -     -                 -                                             
    SP2:                                      -                 -     -     -     -     -                 -                                             
    SP3:                                      -     -           -     -     -     -     -                 -                                             
    SP4:                    -     -     -     -                 -     -     -     -     -                                                               
    SP5:                          -     -     -     -           -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for TSC22D3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSC22D3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAGGGCC
    TSC22D3 Expression
    About this image


    TSC22D3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TSC22D3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSC22D3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522074

    UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576
    Tissue specificity: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and
    kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source
    of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell
    lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes.
    Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH)
    reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages
    involved in the phagocytosis of apoptotic malignant cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TSC22D3: 
              Apoptosis 384HT in human mouse rat
              Adipogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSC22D3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsc22d31 , 5 TSC22 domain family, member 31, 5 86.87(n)1
    89.39(a)1
      X (61.35 cM)5
    146051  NM_001077364.11  NP_001070832.11 
     1405395285 
    chicken
    (Gallus gallus)
    Aves TSC22D36
    Gallus gallus TSC22 domain family, member 3 (TSC22...
    59(a)
    1 ↔ 1
    4(1770827-1772689)
    lizard
    (Anolis carolinensis)
    Reptilia TSC22D36
    TSC22 domain family, member 3
    53(a)
    1 ↔ 1
    GL343686.1(171744-176318)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043841.12   -- 79.19(n)    BC043841.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658312 hypothetical protein MGC65831 81.97(n)   393541  BC056586.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bun6
    bunched
    5(a)
    1 → many
    2L(12455540-12546630)
    worm
    (Caenorhabditis elegans)
    Secernentea C30G4.76
    T18D3.76
    Protein C30G4.7 (C30G4.7) mRNA, complete cds
    Protein T18D3.7, isoform a (T18D3.7) mRNA, complet...
    30(a)
    15(a)
    many ↔ many
    many ↔ many
    X(17056927-17058536) WBGene00016272
    X(12434154-12443915) WBGene00011824


    ENSEMBL Gene Tree for TSC22D3 (if available)
    TreeFam Gene Tree for TSC22D3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSC22D3 gene
    TSC22D12  TSC22D42  TSC22D22  
    3 SIMAP similar genes for TSC22D3 using alignment to 13 protein entries:     T22D3_HUMAN (see all proteins):
    TSC22D4    TSC22D1    TSC22D2

    Find genes that share paralogs with TSC22D3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TSC22D3
    PGOHUM00000258441


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSC22D3 (see all 785)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379040271,2
    C--106955965(+) GAGCCC/TAGTGA 3 -- ds50010--------
    rs1135709731,2
    C,F--106956016(+) GTTCCA/GCTCTT 3 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1922926561,2
    --106956070(+) TCCTCA/GGGGTA 3 -- ds50010--------
    rs1504970891,2
    C--106956141(+) CACTCC/TGAAGC 3 -- ds50010--------
    rs43515341,2
    C,F,A,H--106956244(+) aactcG/Actgag 3 -- ds50019Minor allele frequency- A:0.03NS EA NA 1078
    rs43515351,2
    C--106956461(+) TTTTAC/GAAAAA 3 -- ut310--------
    rs1843080291,2
    --106956502(+) CATTTA/GGAAAA 3 -- ut310--------
    rs1893256521,2
    --106956563(+) GAAAGC/TGTTCA 3 -- ut310--------
    rs558224411,2
    C--106956638(+) CCATCC/TCCTTG 3 -- ut310--------
    rs70522951,2
    C,F,H--106956766(+) TCTCTC/TAACCC 3 -- ut315Minor allele frequency- T:0.01NS NA 508

    HapMap Linkage Disequilibrium report for TSC22D3 (106956451 - 107020572 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSC22D3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSC22D3
    DNA2.0 Custom Variant and Variant Library Synthesis for TSC22D3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300506    OMIM disorders: --


    Find genes that share disorders with TSC22D3           About GenesLikeMe

    1 Novoseek inferred disease relationship for TSC22D3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    emotional stress 35.7 1 7610003 (1)

    Genetic Association Database (GAD): TSC22D3
    Human Genome Epidemiology (HuGE) Navigator: TSC22D3 (1 document)

    Export disorders for TSC22D3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSC22D3 gene, integrated from 10 sources (see all 133):
    (articles sorted by number of sources associating them with TSC22D3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hDIP -- a potential transcriptional regulator related to murine TSC- 22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues. (PubMed id 8982256)1, 2, 3, 9 Vogel P.... Forssmann W.-G. (Biochim. Biophys. Acta 1996)
    2. GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. (PubMed id 15031210)1, 2, 9 Asselin-Labat M.-L.... Pallardy M. (Blood 2004)
    3. Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene. (PubMed id 11313722)1, 2, 9 Cannarile L.... Riccardi C. (Cell Death Differ. 2001)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10. (PubMed id 12393603)1, 2 Berrebi D.... Emilie D. (Blood 2003)
    7. Human TSC-22 gene: no association with type 2 diabetes. (PubMed id 11688842)1, 4 Sugawara F....Seino Y. (Intern. Med. 2001)
    8. Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B. (PubMed id 11468175)1, 2 Ayroldi E.... Riccardi C. (Blood 2001)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. Glucocorticoid-induced leucine zipper (GILZ) promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner. (PubMed id 20018851)1, 9 LatrAc de LatAc P....Biola-Vidamment A. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1831 HGNC: 3051 AceView: DSIPI Ensembl:ENSG00000157514 euGenes: HUgn1831
    ECgene: TSC22D3 H-InvDB: TSC22D3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSC22D3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSC22D3 gene:
    Search GeneIP for patents involving TSC22D3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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