TSC22D3 Gene
protein-coding GIFtS: 53
GCID: GC0XM106956
|
|
TSC22 domain family, member 3(Previous names: delta sleep inducing peptide, immunoreactor )
(Previous symbol: DSIPI)
| |
Aliases
for TSC22D3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TSC22 Domain Family, Member 31 2 | | Glucocorticoid-Induced Leucine Zipper Protein2 3 | | DSIPI1 2 3 5 | | DSIP-Immunoreactive Peptide2 3 | | GILZ1 2 3 5 | | TSC-22-Like Protein2 3 | | TSC-22R1 2 3 | | TSC-22-Related Protein2 3 | | HDIP1 | | DSIP-Immunoreactive Leucine Zipper Protein2 | | DIP1 2 | | TSC-22 Related Protein2 | | Delta Sleep Inducing Peptide, Immunoreactor1 2 | | TSC22 Domain Family Protein 32 | | Delta Sleep-Inducing Peptide Immunoreactor2 3 | | Protein DIP3 |
Export aliases for TSC22D3 gene to outside databasesPrevious GC identifers: GC0XM106763 GC0XM096580 |
Summaries
for TSC22D3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSC22D3:
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, bothof which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene isstimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory andimmunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have beenidentified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptionalactivity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in theanti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-inducedNFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity)
Gene Wiki entry for TSC22D3
|
Genomic Views
for TSC22D3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSC22D3 gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSC22D3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSC22D3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.3 Ensembl cytogenetic band: Xq22.3 HGNC cytogenetic band: Xq22.3TSC22D3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM106956: view genomic region
(about GC identifiers)
Start:
|
106,956,451 bp from pter |
End:
|
107,020,572 bp from pter |
Size:
|
64,122 bases |
Orientation:
|
minus strand |
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Proteins
for TSC22D3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576 (See
protein sequence)Recommended Name: TSC22 domain family protein 3 Size: 134 amino acids; 14810 Da
Subunit: Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity).Interacts with NFKB1
Sequence caution: Sequence=AAH18148.3; Type=Erroneous initiation; Sequence=CAA90644.1; Type=Erroneous initiation;Sequence=CAB53669.1; Type=Frameshift; Positions=4;
Secondary accessions: Q5H9S3 Q5JRI9 Q6FIH6 Q8NAI1 Q8WVB9 Q9UBN5 Q9UG13Alternative splicing: 3 isoforms: Q99576-1 Q99576-3 Q99576-4 (Incomplete sequence. No experimental confirmation available)Explore the universe of human proteins at neXtProt for TSC22D3: NX_Q99576
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99576
TSC22D3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001015881.1 NP_004080.2 NP_932174.1
ENSEMBL proteins: ENSP00000361466 ENSP00000361474 ENSP00000314655 ENSP00000361458 ENSP00000361459 ENSP00000361457 ENSP00000427427 ENSP00000421016 ENSP00000425414 ENSP00000422060 ENSP00000427199 ENSP00000425155 ENSP00000422636 ENSP00000424653 ENSP00000427075 ENSP00000425158 ENSP00000422228 Reactome Protein details: Q99576
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TSC22D3 for ontologies About GeneDecksing
TSC22D3 Antibody Products:
Assay Products for TSC22D3: |
Protein
Domains /
Families
for TSC22D3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSC22D3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q99576ProtoNet protein and cluster: Q99576 1 Blocks protein family: IPB000580 TSC-22 / Dip / Bun family
UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576Domain: The leucine-zipper is involved in homodimerization (By similarity)Similarity: Belongs to the TSC-22/Dip/Bun family |
Function
for TSC22D3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptionalactivity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in theanti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-inducedNFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity)Induction: By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment inmonocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TSC22D3 (NM_004089) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSC22D3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043426 | MRF binding |
IEA | -- |
TSC22D3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tsc22d3tm1.1Ric for TSC22D3
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tsc22d3):
TSC22D3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TSC22D3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | SLC-mediated transmembrane transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for TSC22D3
TSC22D3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSC22D3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/26 Interacting proteins for TSC22D3 (Q995763 ENSP000003614584) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
TAS | 8982256 | | GO:0006970 | response to osmotic stress |
IEA | -- | | GO:0007589 | body fluid secretion |
IEA | -- | | GO:0043066 | negative regulation of apoptotic process |
IEA | -- |
TSC22D3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSC22D3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TSC22D3 for compounds About GeneDecksing
 Browse Tocris compounds for TSC22D3
10/11 Novoseek chemical compound relationships for TSC22D3 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dsip |
97.9 |
30 |
1285360 (1), 8581045 (1), 16637289 (1), 8175965 (1) (see all 28) |
| leucine |
49.7 |
12 |
19875485 (2), 20018851 (2), 15755904 (1), 19275887 (1) (see all 9) |
| dexamethasone |
39.4 |
9 |
16243713 (3), 16293609 (2), 19875485 (1), 19880449 (1) |
| acth |
17 |
2 |
1285360 (1), 7698722 (1) |
| arginine |
11.2 |
2 |
1285360 (1), 1709331 (1) |
| gaba |
9.2 |
2 |
12881986 (1), 7895296 (1) |
| sodium |
0 |
5 |
16720863 (3), 19275887 (1), 16216878 (1) |
| lipid |
0 |
2 |
9448709 (2) |
| steroid |
0 |
1 |
8237103 (1) |
| calcium |
0 |
1 |
8688518 (1) |
Search CenterWatch for drugs/clinical trials and news about TSC22D3 / T22D3
|
Transcripts
for TSC22D3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSC22D3 gene (3 alternative transcripts): NM_001015881.1 NM_004089.3 NM_198057.2 Unigene Cluster for TSC22D3: TSC22 domain family, member 3 Hs.741199 [show with all ESTs]Unigene Representative Sequence: NM_19805717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372390(uc004enf.3) ENST00000372397(uc004eng.3) ENST00000315660(uc004eni.3 uc004enj.3)
ENST00000372383(uc004enh.3) ENST00000372384 ENST00000372382 ENST00000506081
ENST00000514426 ENST00000486554 ENST00000503515 ENST00000514897 ENST00000480691
ENST00000510887 ENST00000502650 ENST00000506724 ENST00000505965 ENST00000502961
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TSC22D3 (NM_004089) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSC22D3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D3 |
Additional cDNA sequence: AB025432.1 AF153603.1 AF183393.1 AF228339.1 AK092645.1 AK092669.1 AK127938.1 AK300535.1 AK311834.1 AL110191.1 AY007119.1 BC018148.1 BC072446.1 BX647854.1 CR533450.1 CR933650.1 Z50781.1 24/28 DOTS entries (see all 28): DT.449448 DT.100768326 DT.100845476 DT.121287702 DT.87079224 DT.75191253 DT.121287741 DT.100845470 DT.100845466 DT.121287753 DT.309972 DT.95262380 DT.97847872 DT.95262390 DT.95262394 DT.97847870 DT.100845472 DT.121287760 DT.92450428 DT.100690726 DT.100707359 DT.100845465 DT.100845471 DT.100845473 24/655 AceView cDNA sequences (see all 655): AI272268 AA599534 BU786911 BU786060 BP342852 AW468339 BU782833 N47563 NM_004089 AI269618 AW022838 AW207662 AI424709 AW262884 BP374371 AI057172 AI262962 BM759952 BU856626 N50052 AI624320 F09314 CD105416 AI598049
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D3 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSC22D3
|
Expression
for TSC22D3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSC22D3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAAGGGCC
About this image
See TSC22D3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSC22D3
SOURCE GeneReport for Unigene cluster: Hs.741199
UniProtKB/Swiss-Prot: T22D3_HUMAN, Q99576Tissue specificity: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney.Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source ofconstitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages,including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated inactivated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as intuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosisof apoptotic malignant cells
SABiosciences Expression via Pathway-Focused PCR Arrays including TSC22D3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSC22D3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSC22D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSC22D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSC22D3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D3 |
Orthologs
for TSC22D3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSC22D3 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TSC22D36 |
-- |
67(a) |
1 ↔ 1 |
Un(23123075-23123323) |
lizard
(Anolis carolinensis) |
Reptilia |
TSC22D36 |
-- |
52(a) |
1 ↔ 1 |
GL343686.1(171752-176318) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC043841.12 |
-- |
79.19(n) |
|
BC043841.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc658312 |
hypothetical protein MGC65831 |
81.97(n) |
|
393541 BC056586.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
bun6 |
bunched |
4(a) |
1 → many |
2L(12455540-12546630) |
worm
(Caenorhabditis elegans) |
Secernentea |
C30G4.76 |
-- |
31(a) |
1 → many |
X(17056853-17058462) |
ENSEMBL Gene Tree for TSC22D3 (if available)
TreeFam Gene Tree for TSC22D3 (if available) |
Paralogs
for TSC22D3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSC22D3 gene
- TSC22D12 TSC22D42 TSC22D22
3 SIMAP similar genes for TSC22D3 using alignment to 13 protein entries: T22D3_HUMAN (see all proteins):TSC22D4 TSC22D1 TSC22D2
TSC22D3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSC22D3
PGOHUM00000258441
|
Genomic Variants
for TSC22D3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSC22D3 (106956451 - 107020572 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSC22D3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSC22D3 |
|
Disorders
/ Diseases
for TSC22D3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSC22D3 for disorders About GeneDecksing
OMIM gene information: 300506
OMIM disorders: --
20/24  diseases for TSC22D3 (see all 24): About MalaCardsmajor depressive disorder brain edema vascular dementia herpes simplex
epithelial ovarian cancer burkitt's lymphoma cushing's syndrome fibromyalgia
diabetes mellitus multiple myeloma rheumatoid arthritis ovarian cancer
dementia crohn's disease myeloma osteoporosis
alzheimer's disease arthritis blindness ischemia
1 Novoseek disease relationship for TSC22D3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| emotional stress |
35.7 |
1 |
7610003 (1) |
Genetic Association Database (GAD): TSC22D3
Human Genome Epidemiology (HuGE) Navigator: TSC22D3 (1 document)
Export disorders for TSC22D3 gene to outside databases
|
Publications
for TSC22D3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSC22D3 gene, integrated from 9 sources (see all 125):
(articles sorted by number of sources associating them with TSC22D3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hDIP -- a potential transcriptional regulator related to murine TSC- 22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues. (PubMed id 8982256)1, 2, 3, 9 Vogel P.... Forssmann W.-G. (1996)
- GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. (PubMed id 15031210)1, 2, 9 Asselin-Labat M.-L.... Pallardy M. (2004)
- Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene. (PubMed id 11313722)1, 2, 9 Cannarile L.... Riccardi C. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10. (PubMed id 12393603)1, 2 Berrebi D.... Emilie D. (2003)
- Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B. (PubMed id 11468175)1, 2 Ayroldi E.... Riccardi C. (2001)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Human TSC-22 gene: no association with type 2 diabetes. (PubMed id 11688842)1, 4 Sugawara F....Seino Y. (2001)
- Glucocorticoid-induced leucine zipper (GILZ) promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner. (PubMed id 20018851)1, 9 LatrAc de LatAc P....Biola-Vidamment A. (2010)
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External Searches for TSC22D3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TSC22D3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TSC22D3 gene
(According to HUGE)
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Specialized Databases showing TSC22D3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for TSC22D3 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for TSC22D3 gene:
Search GeneIP for patents involving TSC22D3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TSC22D3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TSC22D3 | | OriGene shRNA RFP for TSC22D3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSC22D3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSC22D3 | | | OriGene Protein Over-expression Lysate for TSC22D3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSC22D3 | | OriGene 3'-UTR Clone for TSC22D3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSC22D3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSC22D3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSC22D3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSC22D3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSC22D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSC22D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSC22D3 |
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 | | | TSC22D3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D3 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSC22D3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D3 |
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