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Aliases for TSC22D3 Gene

Aliases for TSC22D3 Gene

  • TSC22 Domain Family, Member 3 2 3
  • DSIPI 3 4 6
  • GILZ 3 4 6
  • Glucocorticoid-Induced Leucine Zipper Protein 3 4
  • Delta Sleep Inducing Peptide, Immunoreactor 2 3
  • Delta Sleep-Inducing Peptide Immunoreactor 3 4
  • DSIP-Immunoreactive Peptide 3 4
  • TSC-22-Related Protein 3 4
  • TSC-22-Like Protein 3 4
  • TSC-22R 3 4
  • HDIP 3 4
  • DSIP-Immunoreactive Leucine Zipper Protein 3
  • Glucocorticoid-Induced Leucine Zipper 2
  • TSC22 Domain Family Protein 3 3
  • TSC-22 Related Protein 3
  • Protein DIP 4
  • DIP 3

External Ids for TSC22D3 Gene

Previous HGNC Symbols for TSC22D3 Gene

  • DSIPI

Previous GeneCards Identifiers for TSC22D3 Gene

  • GC0XM106763
  • GC0XM106956
  • GC0XM096580

Summaries for TSC22D3 Gene

Entrez Gene Summary for TSC22D3 Gene

  • The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSC22D3 Gene

TSC22D3 (TSC22 Domain Family, Member 3) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and MRF binding. An important paralog of this gene is TSC22D2.

UniProtKB/Swiss-Prot for TSC22D3 Gene

  • Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

Gene Wiki entry for TSC22D3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D3 Gene

Genomics for TSC22D3 Gene

Regulatory Elements for TSC22D3 Gene

Transcription factor binding sites by QIAGEN in the TSC22D3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSC22D3 Gene

Start:
107,713,221 bp from pter
End:
107,777,342 bp from pter
Size:
64,122 bases
Orientation:
Minus strand

Genomic View for TSC22D3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSC22D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D3 Gene

Proteins for TSC22D3 Gene

  • Protein details for TSC22D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99576-T22D3_HUMAN
    Recommended name:
    TSC22 domain family protein 3
    Protein Accession:
    Q99576
    Secondary Accessions:
    • Q5H9S3
    • Q5JRI9
    • Q6FIH6
    • Q8NAI1
    • Q8WVB9
    • Q9UBN5
    • Q9UG13

    Protein attributes for TSC22D3 Gene

    Size:
    134 amino acids
    Molecular mass:
    14810 Da
    Quaternary structure:
    • Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1. Isoform 1 interacts with MYOD1 (By similarity). Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).
    SequenceCaution:
    • Sequence=AAH18148.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA90644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB53669.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Alternative splice isoforms for TSC22D3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSC22D3 Gene

Proteomics data for TSC22D3 Gene at MOPED

Post-translational modifications for TSC22D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSC22D3 Gene

Domains for TSC22D3 Gene

Protein Domains for TSC22D3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99576

UniProtKB/Swiss-Prot:

T22D3_HUMAN :
  • Q99576
Domain:
  • The leucine-zipper is involved in homodimerization.
Family:
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D3: view

No data available for Gene Families for TSC22D3 Gene

Function for TSC22D3 Gene

Molecular function for TSC22D3 Gene

UniProtKB/Swiss-Prot Function:
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
UniProtKB/Swiss-Prot Induction:
By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Isoform 1 expression is up-regulated by synthetic glucocorticoid dexamethasone in differentiating myoblasts (By similarity).

Gene Ontology (GO) - Molecular Function for TSC22D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043426 MRF binding IEA --
genes like me logo Genes that share ontologies with TSC22D3: view
genes like me logo Genes that share phenotypes with TSC22D3: view

Animal Models for TSC22D3 Gene

MGI Knock Outs for TSC22D3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSC22D3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TSC22D3 Gene

Localization for TSC22D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSC22D3 Gene

Isoform 1: Cytoplasm. Nucleus. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSC22D3 Gene COMPARTMENTS Subcellular localization image for TSC22D3 gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TSC22D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TSC22D3: view

Pathways for TSC22D3 Gene

genes like me logo Genes that share pathways with TSC22D3: view

Pathways by source for TSC22D3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TSC22D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 8982256
GO:0006970 response to osmotic stress IEA --
GO:0007589 body fluid secretion IEA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with TSC22D3: view

Compounds for TSC22D3 Gene

(11) Novoseek inferred chemical compound relationships for TSC22D3 Gene

Compound -log(P) Hits PubMed IDs
dsip 97.9 28
leucine 49.7 11
dexamethasone 39.4 7
acth 17 2
arginine 11.2 2
genes like me logo Genes that share compounds with TSC22D3: view

Transcripts for TSC22D3 Gene

Unigene Clusters for TSC22D3 Gene

TSC22 domain family, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSC22D3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - -
SP14: -

Relevant External Links for TSC22D3 Gene

GeneLoc Exon Structure for
TSC22D3
ECgene alternative splicing isoforms for
TSC22D3

Expression for TSC22D3 Gene

mRNA expression in normal human tissues for TSC22D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSC22D3 Gene

This gene is overexpressed in Whole Blood (5.0).

Protein differential expression in normal tissues for TSC22D3 Gene

This gene is overexpressed in Ovary (18.0), Spleen (11.9), Bone marrow stromal cell (8.7), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSC22D3 Gene

SOURCE GeneReport for Unigene cluster for TSC22D3 Gene Hs.522074

mRNA Expression by UniProt/SwissProt for TSC22D3 Gene

Q99576-T22D3_HUMAN
Tissue specificity: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
genes like me logo Genes that share expressions with TSC22D3: view

In Situ Assay Products

No data available for Expression partners for TSC22D3 Gene

Orthologs for TSC22D3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSC22D3 35
  • 92.83 (n)
  • 94.5 (a)
TSC22D3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsc22d3 35
  • 86.87 (n)
  • 89.39 (a)
Tsc22d3 16
Tsc22d3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSC22D3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSC22D3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSC22D3 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSC22D3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSC22D3 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSC22D3 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8142 35
zebrafish
(Danio rerio)
Actinopterygii zgc65831 35
tsc22d3 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bun 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30G4.7 36
  • 30 (a)
ManyToMany
T18D3.7 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for TSC22D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSC22D3 Gene

ENSEMBL:
Gene Tree for TSC22D3 (if available)
TreeFam:
Gene Tree for TSC22D3 (if available)

Paralogs for TSC22D3 Gene

Paralogs for TSC22D3 Gene

Pseudogenes.org Pseudogenes for TSC22D3 Gene

genes like me logo Genes that share paralogs with TSC22D3: view

Variants for TSC22D3 Gene

Sequence variations from dbSNP and Humsavar for TSC22D3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13194 -- 107,713,541(+) CAACC(C/T)CATTC utr-variant-3-prime
rs1049740 -- 107,713,316(-) TTGAC(A/C)CCTTA utr-variant-3-prime
rs1140394 -- 107,716,885(-) agcct(A/G)ccagc upstream-variant-2KB, utr-variant-5-prime, intron-variant
rs3747406 -- 107,777,739(+) GGCCC(C/T)GTGGG upstream-variant-2KB
rs3924026 -- 107,773,497(+) TTTCA(A/G)CGTCT intron-variant

Relevant External Links for TSC22D3 Gene

HapMap Linkage Disequilibrium report
TSC22D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSC22D3 Gene

Disorders for TSC22D3 Gene

(1) Novoseek inferred disease relationships for TSC22D3 Gene

Disease -log(P) Hits PubMed IDs
emotional stress 35.7 1

Relevant External Links for TSC22D3

Genetic Association Database (GAD)
TSC22D3
Human Genome Epidemiology (HuGE) Navigator
TSC22D3
genes like me logo Genes that share disorders with TSC22D3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for TSC22D3 Gene

Publications for TSC22D3 Gene

  1. hDIP -- a potential transcriptional regulator related to murine TSC- 22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues. (PMID: 8982256) Vogel P. … Forssmann W.-G. (Biochim. Biophys. Acta 1996) 2 3 4 23
  2. Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene. (PMID: 11313722) Cannarile L. … Riccardi C. (Cell Death Differ. 2001) 3 4 23
  3. GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. (PMID: 15031210) Asselin-Labat M.-L. … Pallardy M. (Blood 2004) 3 4 23
  4. FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced leucine zipper expression. (PMID: 15705665) Asselin-Labat M.L. … Pallardy M. (Mol. Endocrinol. 2005) 3 23
  5. The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis. (PMID: 19875485) Lekva T. … Jemtland R. (J. Clin. Endocrinol. Metab. 2010) 3 23

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Sources for TSC22D3 Gene

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