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Aliases for TSC22D2 Gene

Aliases for TSC22D2 Gene

  • TSC22 Domain Family Member 2 2 3 5
  • TSC22-Related-Inducible Leucine Zipper Protein 4 3 4
  • TSC22 Domain Family, Member 2 2
  • TSC22 Domain Family Protein 2 3
  • TSC22 Domain Family 2 3
  • KIAA0669 4
  • TILZ4a 3
  • TILZ4b 3
  • TILZ4c 3
  • TILZ4 4

External Ids for TSC22D2 Gene

Previous GeneCards Identifiers for TSC22D2 Gene

  • GC03P151609
  • GC03P150126
  • GC03P147500

Summaries for TSC22D2 Gene

GeneCards Summary for TSC22D2 Gene

TSC22D2 (TSC22 Domain Family Member 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TSC22D1.

Additional gene information for TSC22D2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D2 Gene

Genomics for TSC22D2 Gene

Regulatory Elements for TSC22D2 Gene

Enhancers for TSC22D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H150384 1.9 FANTOM5 Ensembl ENCODE dbSUPER 26.9 -23.2 -23192 1.9 HDGF PKNOX1 ATF1 MLX ARID4B TCF12 ZNF207 ATF7 RUNX3 PPARG TSC22D2 SERP1 SIAH2 LINC01214
GH03H150375 1.5 Ensembl ENCODE dbSUPER 22.9 -32.0 -31990 1.5 ATF1 YY1 ZNF766 ELK1 ATF7 ZNF592 MEF2D MAFF ATF4 SMARCA4 TSC22D2 COMMD2 EIF2A LINC01214
GH03H150344 1.4 Ensembl ENCODE dbSUPER 15.1 -60.0 -59968 8.4 TBP PKNOX1 NFIB SREBF2 SIN3A BMI1 RAD21 BRCA1 ZBTB40 RFX5 COMMD2 TSC22D2 EIF2A P2RY14 LINC01214
GH03H149811 1.5 FANTOM5 ENCODE 11.2 -593.5 -593474 5.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS PFN2 RNF13 COMMD2 TSC22D2 PPIAP73 RNU6-720P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSC22D2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TSC22D2 Gene

Genomic Locations for TSC22D2 Gene
58,097 bases
Plus strand

Genomic View for TSC22D2 Gene

Genes around TSC22D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSC22D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSC22D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D2 Gene

Proteins for TSC22D2 Gene

  • Protein details for TSC22D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TSC22 domain family protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DNI5
    • Q6PI50
    • Q9H2Z6
    • Q9H2Z7
    • Q9H2Z8

    Protein attributes for TSC22D2 Gene

    780 amino acids
    Molecular mass:
    79228 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31644.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSC22D2 Gene


neXtProt entry for TSC22D2 Gene

Post-translational modifications for TSC22D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSC22D2 Gene

No data available for DME Specific Peptides for TSC22D2 Gene

Domains & Families for TSC22D2 Gene

Gene Families for TSC22D2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TSC22D2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TSC-22/Dip/Bun family.
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D2: view

Function for TSC22D2 Gene

Phenotypes From GWAS Catalog for TSC22D2 Gene

Gene Ontology (GO) - Molecular Function for TSC22D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TSC22D2: view
genes like me logo Genes that share phenotypes with TSC22D2: view

miRNA for TSC22D2 Gene

miRTarBase miRNAs that target TSC22D2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSC22D2 Gene

Localization for TSC22D2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSC22D2 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSC22D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSC22D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSC22D2 Gene

Pathways & Interactions for TSC22D2 Gene

SuperPathways for TSC22D2 Gene

No Data Available

Interacting Proteins for TSC22D2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: O75157-T22D2_HUMAN ENSP00000354543 for TSC22D2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TSC22D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006970 response to osmotic stress IEA --
genes like me logo Genes that share ontologies with TSC22D2: view

No data available for Pathways by source and SIGNOR curated interactions for TSC22D2 Gene

Drugs & Compounds for TSC22D2 Gene

No Compound Related Data Available

Transcripts for TSC22D2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for TSC22D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSC22D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSC22D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSC22D2 Gene

This gene is overexpressed in Cervix (22.0) and Adrenal (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSC22D2 Gene

Protein tissue co-expression partners for TSC22D2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSC22D2 Gene:


SOURCE GeneReport for Unigene cluster for TSC22D2 Gene:


Evidence on tissue expression from TISSUES for TSC22D2 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Intestine(3.2)
genes like me logo Genes that share expression patterns with TSC22D2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSC22D2 Gene

Orthologs for TSC22D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSC22D2 33 34
  • 99.71 (n)
(Canis familiaris)
Mammalia TSC22D2 33 34
  • 89.57 (n)
(Bos Taurus)
Mammalia TSC22D2 33 34
  • 88.69 (n)
(Rattus norvegicus)
Mammalia Tsc22d2 33
  • 87.88 (n)
(Mus musculus)
Mammalia Tsc22d2 33 16 34
  • 87.66 (n)
(Ornithorhynchus anatinus)
Mammalia TSC22D2 34
  • 82 (a)
(Monodelphis domestica)
Mammalia TSC22D2 34
  • 69 (a)
(Gallus gallus)
Aves LOC100859827 33
  • 71.9 (n)
TSC22D2 34
  • 65 (a)
(Anolis carolinensis)
Reptilia TSC22D2 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tsc22d2 33
  • 62.04 (n)
Str.17767 33
(Danio rerio)
Actinopterygii tsc22d2 34
  • 42 (a)
kiaa0669 33
fruit fly
(Drosophila melanogaster)
Insecta bun 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C30G4.7 34
  • 40 (a)
T18D3.7 34
  • 28 (a)
Species where no ortholog for TSC22D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSC22D2 Gene

Gene Tree for TSC22D2 (if available)
Gene Tree for TSC22D2 (if available)

Paralogs for TSC22D2 Gene

Paralogs for TSC22D2 Gene

(3) SIMAP similar genes for TSC22D2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSC22D2: view

Variants for TSC22D2 Gene

Sequence variations from dbSNP and Humsavar for TSC22D2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000042083 -- 150,427,769(+) TCCCT(A/C/G)CCTCC intron-variant
rs1000080349 -- 150,433,408(+) AGCTA(C/T)GTATT intron-variant
rs1000234927 -- 150,439,882(+) ATGGG(A/G)CAAAT intron-variant
rs1000285537 -- 150,439,611(+) CATGT(G/T)AGATT intron-variant
rs1000322215 -- 150,426,568(+) CTAAA(C/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSC22D2 Gene

Variant ID Type Subtype PubMed ID
nsv829755 CNV loss 17160897
nsv822291 CNV gain 20364138
nsv1136775 CNV deletion 24896259
esv3598157 CNV gain 21293372
esv3598156 CNV loss 21293372
esv29861 CNV loss 19812545
dgv8649n54 CNV loss 21841781

Variation tolerance for TSC22D2 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.15; 69.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSC22D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSC22D2 Gene

Disorders for TSC22D2 Gene

Relevant External Links for TSC22D2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSC22D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSC22D2 Gene

Publications for TSC22D2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2. (PMID: 27337956) Li Q … Xiong W (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  5. TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer. (PMID: 27573352) Liang F … Xiong W (International journal of oncology 2016) 3 60

Products for TSC22D2 Gene

Sources for TSC22D2 Gene

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