TSC22D2 Gene
protein-coding GIFtS: 45
GCID: GC03P150126
|
|
TSC22 domain family, member 2
| |
Aliases
for TSC22D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TSC22 Domain Family, Member 21 2 | | TSC22-Related-Inducible Leucine Zipper Protein 42 3 | | TILZ4a1 2 | | TSC22 Domain Family 22 | | TILZ4b1 2 | | TSC22 Domain Family Protein 22 | | TILZ4c1 2 | | TILZ43 | | KIAA06691 3 | | |
Export aliases for TSC22D2 gene to outside databasesPrevious GC identifers: GC03P151609 GC03P147500 |
Summaries
for TSC22D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TSC22D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSC22D2 gene promoter:
STAT5B GR GR-beta Arnt YY1 AREB6 GR-alpha ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSC22D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSC22D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q25.1TSC22D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P150126: view genomic region
(about GC identifiers)
Start:
|
150,126,122 bp from pter |
End:
|
150,177,903 bp from pter |
Size:
|
51,782 bases |
Orientation:
|
plus strand |
|
Proteins
for TSC22D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T22D2_HUMAN, O75157 (See
protein sequence)Recommended Name: TSC22 domain family protein 2 Size: 780 amino acids; 79228 Da
Sequence caution: Sequence=BAA31644.2; Type=Erroneous initiation;
Secondary accessions: D3DNI5 Q6PI50 Q9H2Z6 Q9H2Z7 Q9H2Z8Alternative splicing: 2 isoforms: O75157-1 O75157-2 Explore the universe of human proteins at neXtProt for TSC22D2: NX_O75157
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75157
TSC22D2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055594.1
ENSEMBL proteins: ENSP00000354543 ENSP00000418149 ENSP00000417747 ENSP00000420689 ENSP00000354893
Human Recombinant Protein Products for TSC22D2:
TSC22D2 Antibody Products:
Assay Products for TSC22D2: |
Protein
Domains /
Families
for TSC22D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSC22D2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75157ProtoNet protein and cluster: O75157 1 Blocks protein family: IPB000580 TSC-22 / Dip / Bun family
UniProtKB/Swiss-Prot: T22D2_HUMAN, O75157Similarity: Belongs to the TSC-22/Dip/Bun family |
Function
for TSC22D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- |
TSC22D2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSC22D2 (NM_014779) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSC22D2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D2 |
|
Pathways & Interactions
for TSC22D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSC22D2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TSC22D2 (ENSP000003545434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006970 | response to osmotic stress |
IEA | -- |
TSC22D2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSC22D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSC22D2
Search CenterWatch for drugs/clinical trials and news about TSC22D2 / T22D2
|
Transcripts
for TSC22D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSC22D2 gene: NM_014779.2 Unigene Clusters for TSC22D2: TSC22 domain family, member 2 Hs.722470 , Hs.730710 [show with all ESTs]Unigene Representative Sequences: BC036355, AB0145697 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361875(uc003exv.3 uc003exw.3 uc003exx.3) ENST00000480589
ENST00000466814 ENST00000485421 ENST00000492828 ENST00000460316 ENST00000361136
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSC22D2 (NM_014779) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSC22D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D2 |
Additional cDNA sequence: AB014569.1 AF201290.1 AF201291.1 AF201292.1 AK297383.1 AK297748.1 BC044643.1 7 DOTS entries: DT.211116 DT.92455418 DT.95276070 DT.40131208 DT.120887986 DT.86993102 DT.120887990 24/189 AceView cDNA sequences (see all 189): AA400064 AK123861 AF201292 BE840373 AA286956 BM984748 AA040290 NM_014779 AA233818 AW276993 BM698612 BE840386 BE840388 BE812057 BM721327 AB014569 BE840317 BE840409 AW236749 BE840397 CD520523 BE840394 BE696553 AW270114
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSC22D2
|
Expression
for TSC22D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSC22D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGACTGCCT
About this image
See TSC22D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSC22D2
SOURCE GeneReport for Unigene clusters: Hs.722470 Hs.730710
SABiosciences Custom PCR Arrays for TSC22D2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSC22D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSC22D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSC22D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSC22D2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D2 |
Orthologs
for TSC22D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSC22D2 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for TSC22D2 (if available)
TreeFam Gene Tree for TSC22D2 (if available) |
Paralogs
for TSC22D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSC22D2 gene
- TSC22D32 TSC22D12 TSC22D42
3 SIMAP similar genes for TSC22D2 using alignment to 5 protein entries: T22D2_HUMAN (see all proteins):TSC22D4 TSC22D1 TSC22D3
TSC22D2 for paralogs About GeneDecksing
|
Genomic Variants
for TSC22D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSC22D2 (150126122 - 150177903 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TSC22D2
1 CNV: 68482 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSC22D2 |
|
Disorders
/ Diseases
for TSC22D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TSC22D2 for disorders About MalaCards
TSC22D2 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TSC22D2 (2 documents)
Export disorders for TSC22D2 gene to outside databases
|
Publications
for TSC22D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSC22D2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSC22D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1 Dastani Z....Kathiresan S. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. (PubMed id 20149264)1 Gluderer S....Stocker H. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1 Gevaert K.... Vandekerckhove J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TSC22D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSC22D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSC22D2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TSC22D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSC22D2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSC22D2 gene:
Search GeneIP for patents involving TSC22D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSC22D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSC22D2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSC22D2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSC22D2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSC22D2 | | OriGene 3'-UTR Clone for TSC22D2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSC22D2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSC22D2 | | OriGene Custom Protein Services for TSC22D2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSC22D2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSC22D2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSC22D2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSC22D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSC22D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSC22D2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TSC22D2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TSC22D2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSC22D2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TSC22D2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSC22D2 |
| |  | |
|
|
|
