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Aliases for TSC22D2 Gene

Aliases for TSC22D2 Gene

  • TSC22 Domain Family Member 2 2 3 5
  • TSC22-Related-Inducible Leucine Zipper Protein 4 3 4
  • TSC22 Domain Family, Member 2 2 3
  • TSC22 Domain Family 2 3
  • KIAA0669 4
  • TILZ4a 3
  • TILZ4b 3
  • TILZ4c 3
  • TILZ4 4

External Ids for TSC22D2 Gene

Previous GeneCards Identifiers for TSC22D2 Gene

  • GC03P151609
  • GC03P150126
  • GC03P147500

Summaries for TSC22D2 Gene

GeneCards Summary for TSC22D2 Gene

TSC22D2 (TSC22 Domain Family Member 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TSC22D3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D2 Gene

Genomics for TSC22D2 Gene

Regulatory Elements for TSC22D2 Gene

Genomic Location for TSC22D2 Gene

Chromosome:
3
Start:
150,408,335 bp from pter
End:
150,466,431 bp from pter
Size:
58,097 bases
Orientation:
Plus strand

Genomic View for TSC22D2 Gene

Genes around TSC22D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSC22D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSC22D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D2 Gene

Proteins for TSC22D2 Gene

  • Protein details for TSC22D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75157-T22D2_HUMAN
    Recommended name:
    TSC22 domain family protein 2
    Protein Accession:
    O75157
    Secondary Accessions:
    • D3DNI5
    • Q6PI50
    • Q9H2Z6
    • Q9H2Z7
    • Q9H2Z8

    Protein attributes for TSC22D2 Gene

    Size:
    780 amino acids
    Molecular mass:
    79228 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31644.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSC22D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSC22D2 Gene

Proteomics data for TSC22D2 Gene at MOPED

Post-translational modifications for TSC22D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSC22D2 Gene

No data available for DME Specific Peptides for TSC22D2 Gene

Domains & Families for TSC22D2 Gene

Protein Domains for TSC22D2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75157

UniProtKB/Swiss-Prot:

T22D2_HUMAN :
  • Belongs to the TSC-22/Dip/Bun family.
Family:
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D2: view

No data available for Gene Families for TSC22D2 Gene

Function for TSC22D2 Gene

genes like me logo Genes that share phenotypes with TSC22D2: view

Animal Model Products

miRNA for TSC22D2 Gene

miRTarBase miRNAs that target TSC22D2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSC22D2 Gene

Localization for TSC22D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSC22D2 Gene COMPARTMENTS Subcellular localization image for TSC22D2 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSC22D2 Gene

Pathways & Interactions for TSC22D2 Gene

SuperPathways for TSC22D2 Gene

No Data Available

Interacting Proteins for TSC22D2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354543%0d%0a9606.ENSP00000171111%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354543 for TSC22D2 Gene via STRING

Gene Ontology (GO) - Biological Process for TSC22D2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TSC22D2 Gene

Drugs & Compounds for TSC22D2 Gene

No Compound Related Data Available

Transcripts for TSC22D2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for TSC22D2 Gene

GeneLoc Exon Structure for
TSC22D2
ECgene alternative splicing isoforms for
TSC22D2

Expression for TSC22D2 Gene

mRNA expression in normal human tissues for TSC22D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSC22D2 Gene

This gene is overexpressed in Cervix (22.0) and Adrenal (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSC22D2 Gene



SOURCE GeneReport for Unigene cluster for TSC22D2 Gene Hs.722470

genes like me logo Genes that share expression patterns with TSC22D2: view

Protein tissue co-expression partners for TSC22D2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSC22D2 Gene

Orthologs for TSC22D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSC22D2 35
  • 88.69 (n)
  • 85.75 (a)
TSC22D2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSC22D2 35
  • 89.57 (n)
  • 88.35 (a)
TSC22D2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsc22d2 35
  • 87.66 (n)
  • 86.96 (a)
Tsc22d2 16
Tsc22d2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSC22D2 35
  • 99.71 (n)
  • 99.66 (a)
TSC22D2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsc22d2 35
  • 87.88 (n)
  • 86.17 (a)
oppossum
(Monodelphis domestica)
Mammalia TSC22D2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSC22D2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859827 35
  • 71.9 (n)
  • 67.16 (a)
TSC22D2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSC22D2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17767 35
tsc22d2 35
  • 62.04 (n)
  • 58.37 (a)
zebrafish
(Danio rerio)
Actinopterygii kiaa0669 35
tsc22d2 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bun 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30G4.7 36
  • 40 (a)
ManyToMany
T18D3.7 36
  • 28 (a)
ManyToMany
Species with no ortholog for TSC22D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSC22D2 Gene

ENSEMBL:
Gene Tree for TSC22D2 (if available)
TreeFam:
Gene Tree for TSC22D2 (if available)

Paralogs for TSC22D2 Gene

Paralogs for TSC22D2 Gene

(3) SIMAP similar genes for TSC22D2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSC22D2: view

Variants for TSC22D2 Gene

Sequence variations from dbSNP and Humsavar for TSC22D2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs879634 - 150,410,605(-) GGAAG(C/T)ATTCT nc-transcript-variant, reference, missense
rs1061239 -- 150,459,357(+) GTCAC(C/G)AGTTA nc-transcript-variant, utr-variant-3-prime
rs1376027 -- 150,449,030(-) GCTCC(C/T)AGTAC intron-variant
rs1450338 -- 150,429,698(+) TGAAA(C/T)TCATG intron-variant
rs1450339 -- 150,417,404(+) CATAC(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSC22D2 Gene

Variant ID Type Subtype PubMed ID
nsv829755 CNV Loss 17160897
nsv877645 CNV Loss 21882294
esv29861 CNV Loss 19812545
nsv822291 CNV Gain 20364138

Variation tolerance for TSC22D2 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.15; 69.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSC22D2 Gene

HapMap Linkage Disequilibrium report
TSC22D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSC22D2 Gene

Disorders for TSC22D2 Gene

Relevant External Links for TSC22D2

Human Genome Epidemiology (HuGE) Navigator
TSC22D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSC22D2

No disorders were found for TSC22D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSC22D2 Gene

Publications for TSC22D2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. (PMID: 23382044) Hast B.E. … Major M.B. (Cancer Res. 2013) 3
  4. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z. … Kathiresan S. (PLoS Genet. 2012) 3
  5. Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. (PMID: 20149264) Gluderer S. … Stocker H. (J. Biol. 2010) 3

Products for TSC22D2 Gene

Sources for TSC22D2 Gene

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