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Aliases for TSC22D2 Gene

Aliases for TSC22D2 Gene

  • TSC22 Domain Family, Member 2 2 3
  • TSC22-Related-Inducible Leucine Zipper Protein 4 3 4
  • TSC22 Domain Family Protein 2 3
  • TSC22 Domain Family 2 3
  • KIAA0669 4
  • TILZ4a 3
  • TILZ4b 3
  • TILZ4c 3
  • TILZ4 4

External Ids for TSC22D2 Gene

Previous GeneCards Identifiers for TSC22D2 Gene

  • GC03P151609
  • GC03P150126
  • GC03P147500

Summaries for TSC22D2 Gene

GeneCards Summary for TSC22D2 Gene

TSC22D2 (TSC22 Domain Family, Member 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TSC22D3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D2 Gene

Genomics for TSC22D2 Gene

Regulatory Elements for TSC22D2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSC22D2 Gene

150,408,314 bp from pter
150,466,431 bp from pter
58,118 bases
Plus strand

Genomic View for TSC22D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSC22D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D2 Gene

Proteins for TSC22D2 Gene

  • Protein details for TSC22D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TSC22 domain family protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DNI5
    • Q6PI50
    • Q9H2Z6
    • Q9H2Z7
    • Q9H2Z8

    Protein attributes for TSC22D2 Gene

    780 amino acids
    Molecular mass:
    79228 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31644.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSC22D2 Gene


neXtProt entry for TSC22D2 Gene

Proteomics data for TSC22D2 Gene at MOPED

Post-translational modifications for TSC22D2 Gene

  • Ubiquitination at Lys698
  • Modification sites at PhosphoSitePlus

Other Protein References for TSC22D2 Gene

No data available for DME Specific Peptides for TSC22D2 Gene

Domains for TSC22D2 Gene

Protein Domains for TSC22D2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TSC-22/Dip/Bun family.
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D2: view

No data available for Gene Families for TSC22D2 Gene

Function for TSC22D2 Gene

Gene Ontology (GO) - Molecular Function for TSC22D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with TSC22D2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSC22D2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSC22D2 Gene

Localization for TSC22D2 Gene

Subcellular locations from

Jensen Localization Image for TSC22D2 Gene COMPARTMENTS Subcellular localization image for TSC22D2 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSC22D2 Gene

Pathways for TSC22D2 Gene

SuperPathways for TSC22D2 Gene

No Data Available

Interacting Proteins for TSC22D2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000354543 for TSC22D2 Gene via STRING

Gene Ontology (GO) - Biological Process for TSC22D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006970 response to osmotic stress IEA --
genes like me logo Genes that share ontologies with TSC22D2: view

No data available for Pathways by source for TSC22D2 Gene

Transcripts for TSC22D2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSC22D2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for TSC22D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSC22D2 Gene

mRNA expression in normal human tissues for TSC22D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TSC22D2 Gene

This gene is overexpressed in Cervix (22.0) and Adrenal (14.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSC22D2 Gene

SOURCE GeneReport for Unigene cluster for TSC22D2 Gene Hs.722470

genes like me logo Genes that share expressions with TSC22D2: view

Expression partners for TSC22D2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSC22D2 Gene

Orthologs for TSC22D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSC22D2 35
  • 88.69 (n)
  • 85.75 (a)
TSC22D2 36
  • 86 (a)
(Canis familiaris)
Mammalia TSC22D2 35
  • 89.57 (n)
  • 88.35 (a)
TSC22D2 36
  • 88 (a)
(Mus musculus)
Mammalia Tsc22d2 35
  • 87.66 (n)
  • 86.96 (a)
Tsc22d2 16
Tsc22d2 36
  • 86 (a)
(Pan troglodytes)
Mammalia TSC22D2 35
  • 99.71 (n)
  • 99.66 (a)
TSC22D2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tsc22d2 35
  • 87.88 (n)
  • 86.17 (a)
(Monodelphis domestica)
Mammalia TSC22D2 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia TSC22D2 36
  • 82 (a)
(Gallus gallus)
Aves LOC100859827 35
  • 71.9 (n)
  • 67.16 (a)
TSC22D2 36
  • 65 (a)
(Anolis carolinensis)
Reptilia TSC22D2 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17767 35
tsc22d2 35
  • 62.04 (n)
  • 58.37 (a)
(Danio rerio)
Actinopterygii kiaa0669 35
tsc22d2 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta bun 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C30G4.7 36
  • 40 (a)
T18D3.7 36
  • 28 (a)
Species with no ortholog for TSC22D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSC22D2 Gene

Gene Tree for TSC22D2 (if available)
Gene Tree for TSC22D2 (if available)

Paralogs for TSC22D2 Gene

Paralogs for TSC22D2 Gene

(3) SIMAP similar genes for TSC22D2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TSC22D2: view

Variants for TSC22D2 Gene

Sequence variations from dbSNP and Humsavar for TSC22D2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs879634 - 150,410,605(-) GGAAG(C/T)ATTCT missense, reference, nc-transcript-variant
rs1061239 -- 150,459,357(+) GTCAC(C/G)AGTTA utr-variant-3-prime
rs1376027 -- 150,449,030(-) GCTCC(C/T)AGTAC intron-variant
rs1450338 -- 150,429,698(+) TGAAA(C/T)TCATG intron-variant
rs1450339 -- 150,417,404(+) CATAC(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSC22D2 Gene

Variant ID Type Subtype PubMed ID
nsv829755 CNV Loss 17160897
nsv877645 CNV Loss 21882294
esv29861 CNV Loss 19812545
nsv822291 CNV Gain 20364138

Relevant External Links for TSC22D2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSC22D2 Gene

Disorders for TSC22D2 Gene

Relevant External Links for TSC22D2

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TSC22D2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TSC22D2 Gene

Publications for TSC22D2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. (PMID: 20149264) Gluderer S. … Stocker H. (J. Biol. 2010) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for TSC22D2 Gene

Sources for TSC22D2 Gene

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