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Aliases for TSC22D1 Gene

Aliases for TSC22D1 Gene

  • TSC22 Domain Family, Member 1 2 3
  • TSC22 3 4 6
  • Transforming Growth Factor Beta-1-Induced Transcript 4 Protein 3 4
  • TGFB-Stimulated Clone 22 Homolog 3 4
  • Regulatory Protein TSC-22 3 4
  • Cerebral Protein 2 3 4
  • TGFB1I4 3 4
  • Transforming Growth Factor Beta-Stimulated Protein TSC-22 3
  • Transforming Growth Factor Beta 1 Induced Transcript 4 2
  • Transcriptional Regulator TSC-22 3
  • TSC22 Domain Family Protein 1 3
  • TGFbeta-Stimulated Clone 22 3
  • KIAA1994 4
  • Ptg-2 3

External Ids for TSC22D1 Gene

Previous HGNC Symbols for TSC22D1 Gene

  • TGFB1I4

Previous GeneCards Identifiers for TSC22D1 Gene

  • GC13M043906
  • GC13M045007
  • GC13M025809

Summaries for TSC22D1 Gene

Entrez Gene Summary for TSC22D1 Gene

  • This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for TSC22D1 Gene

TSC22D1 (TSC22 Domain Family, Member 1) is a Protein Coding gene. Diseases associated with TSC22D1 include lung adenoma. Among its related pathways are Development_TGF-beta receptor signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TSC22D2.

UniProtKB/Swiss-Prot for TSC22D1 Gene

  • Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter

Gene Wiki entry for TSC22D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSC22D1 Gene

Genomics for TSC22D1 Gene

Regulatory Elements for TSC22D1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSC22D1 Gene

Start:
44,432,143 bp from pter
End:
44,577,147 bp from pter
Size:
145,005 bases
Orientation:
Minus strand

Genomic View for TSC22D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSC22D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSC22D1 Gene

Proteins for TSC22D1 Gene

  • Protein details for TSC22D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15714-T22D1_HUMAN
    Recommended name:
    TSC22 domain family protein 1
    Protein Accession:
    Q15714
    Secondary Accessions:
    • B3KRL7
    • B9EGI0
    • O00666
    • Q6AHX5
    • Q6IBU1
    • Q8NCN1
    • Q96JS5

    Protein attributes for TSC22D1 Gene

    Size:
    1073 amino acids
    Molecular mass:
    109677 Da
    Quaternary structure:
    • Homodimer or heterodimer. Can form a heterodimer with TSC22D4
    SequenceCaution:
    • Sequence=BAC02703.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSC22D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSC22D1 Gene

Proteomics data for TSC22D1 Gene at MOPED

Post-translational modifications for TSC22D1 Gene

  • Ubiquitination at Lys992
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TSC22D1 Gene

Domains for TSC22D1 Gene

Protein Domains for TSC22D1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15714

UniProtKB/Swiss-Prot:

T22D1_HUMAN :
  • Q15714
Family:
  • Belongs to the TSC-22/Dip/Bun family.
genes like me logo Genes that share domains with TSC22D1: view

No data available for Gene Families for TSC22D1 Gene

Function for TSC22D1 Gene

Molecular function for TSC22D1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter
UniProtKB/Swiss-Prot Induction: In aortic endothelial cells, induced by cytokines, including TGFB1

Gene Ontology (GO) - Molecular Function for TSC22D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 18325344
genes like me logo Genes that share ontologies with TSC22D1: view

Phenotypes for TSC22D1 Gene

genes like me logo Genes that share phenotypes with TSC22D1: view

Animal Models for TSC22D1 Gene

MGI Knock Outs for TSC22D1:

Animal Model Products

CRISPR Products

miRNA for TSC22D1 Gene

miRTarBase miRNAs that target TSC22D1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSC22D1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TSC22D1 Gene

Localization for TSC22D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSC22D1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSC22D1 Gene COMPARTMENTS Subcellular localization image for TSC22D1 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TSC22D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSC22D1: view

Pathways for TSC22D1 Gene

genes like me logo Genes that share pathways with TSC22D1: view

Pathways by source for TSC22D1 Gene

1 GeneGo (Thomson Reuters) pathway for TSC22D1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TSC22D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9022669
GO:0008284 positive regulation of cell proliferation IEA --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TSC22D1: view

Compounds for TSC22D1 Gene

(4) Novoseek inferred chemical compound relationships for TSC22D1 Gene

Compound -log(P) Hits PubMed IDs
vesnarinone 80.7 5
leucine 62.9 15
cycloheximide 21.9 1
5fluorouracil 14.2 2
genes like me logo Genes that share compounds with TSC22D1: view

Transcripts for TSC22D1 Gene

Unigene Clusters for TSC22D1 Gene

TSC22 domain family, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSC22D1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSC22D1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f ^ 12
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - -
SP8:
SP9: -
SP10:
SP11: - - - - - - - - - - - - - - - - - - - - - -
SP12: -

Relevant External Links for TSC22D1 Gene

GeneLoc Exon Structure for
TSC22D1
ECgene alternative splicing isoforms for
TSC22D1

Expression for TSC22D1 Gene

mRNA expression in normal human tissues for TSC22D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSC22D1 Gene

SOURCE GeneReport for Unigene cluster for TSC22D1 Gene Hs.436383

mRNA Expression by UniProt/SwissProt for TSC22D1 Gene

Q15714-T22D1_HUMAN
Tissue specificity: Widely expressed in fetal and adult tissues
genes like me logo Genes that share expressions with TSC22D1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TSC22D1 Gene

Orthologs for TSC22D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSC22D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSC22D1 35
  • 99.63 (n)
  • 99.44 (a)
TSC22D1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
OneToMany
TSC22D1 36
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TSC22D1 35
  • 89.64 (n)
  • 89.92 (a)
TSC22D1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsc22d1 35
  • 87.36 (n)
  • 86.52 (a)
Tsc22d1 16
Tsc22d1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSC22D1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSC22D1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsc22d1 35
  • 87.24 (n)
  • 85.89 (a)
chicken
(Gallus gallus)
Aves TSC22D1 35
  • 73.33 (n)
  • 70.25 (a)
TSC22D1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSC22D1 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8414 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1572 35
tsc22d1 35
  • 64.56 (n)
  • 59.84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9702 35
zebrafish
(Danio rerio)
Actinopterygii tsc22d1 36
  • 42 (a)
OneToMany
TSC22D1 (1 of 2) 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bun 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30G4.7 36
  • 37 (a)
ManyToMany
T18D3.7 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
Species with no ortholog for TSC22D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSC22D1 Gene

ENSEMBL:
Gene Tree for TSC22D1 (if available)
TreeFam:
Gene Tree for TSC22D1 (if available)

Paralogs for TSC22D1 Gene

Paralogs for TSC22D1 Gene

Selected SIMAP similar genes for TSC22D1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSC22D1: view

Variants for TSC22D1 Gene

Sequence variations from dbSNP and Humsavar for TSC22D1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs11692 -- 44,433,561(-) TGTTG(C/G)ACTTG utr-variant-3-prime
rs12044 -- 44,433,760(-) GCTGC(C/T)GAATA utr-variant-3-prime
rs15121 -- 44,433,734(-) TTGTT(C/G)ACTGA utr-variant-3-prime
rs928708 -- 44,511,086(+) GACCA(G/T)CCTGG intron-variant
rs968973 -- 44,490,594(-) TTAGC(A/G)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSC22D1 Gene

Variant ID Type Subtype PubMed ID
esv2677067 CNV Deletion 23128226
esv2747332 CNV Deletion 23290073
esv23675 CNV Loss 19812545
esv271017 CNV Insertion 20981092
esv273649 CNV Insertion 20981092
esv2669361 CNV Deletion 23128226
esv2661792 CNV Deletion 23128226

Relevant External Links for TSC22D1 Gene

HapMap Linkage Disequilibrium report
TSC22D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSC22D1 Gene

Disorders for TSC22D1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TSC22D1 Gene including...

Search for TSC22D1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TSC22D1 Gene

(7) Novoseek inferred disease relationships for TSC22D1 Gene

Disease -log(P) Hits PubMed IDs
salivary gland cancer 92.7 14
astrocytoma 29.4 3
diabetic nephropathies 26.1 5
tumors 20.4 28
brain tumors 18.3 2

Relevant External Links for TSC22D1

Genetic Association Database (GAD)
TSC22D1
Human Genome Epidemiology (HuGE) Navigator
TSC22D1
genes like me logo Genes that share disorders with TSC22D1: view

No data available for UniProtKB/Swiss-Prot for TSC22D1 Gene

Publications for TSC22D1 Gene

  1. Cloning of the human homologue of the TGF beta-stimulated clone 22 gene. (PMID: 8651929) Jay P. … Berta P. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. (PMID: 9022669) Ohta S. … Nagata K. (Eur. J. Biochem. 1996) 2 3 4 23
  3. TGF-beta1 and TSC-22 gene polymorphisms and susceptibility to microvascular complications in type 2 diabetes. (PMID: 17622752) Buraczynska M. … Ksiazek A. (Nephron Physiol 2007) 3 23 48
  4. Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. (PMID: 17690703) Lu Y. … Kitamura T. (Leukemia 2007) 3 23
  5. Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. (PMID: 16106424) Rentsch C.A. … Wetterwald A. (Int. J. Cancer 2006) 3 23

Products for TSC22D1 Gene

Sources for TSC22D1 Gene

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