Aliases for TSC22D1 Gene
External Ids for TSC22D1 Gene
Previous HGNC Symbols for TSC22D1 Gene
Previous GeneCards Identifiers for TSC22D1 Gene
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for TSC22D1 Gene
TSC22D1 (TSC22 Domain Family Member 1) is a Protein Coding gene. Diseases associated with TSC22D1 include salivary gland cancer and brain sarcoma. Among its related pathways are Development_TGF-beta receptor signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TSC22D2.
UniProtKB/Swiss-Prot for TSC22D1 Gene
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.