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Aliases for TSACC Gene

Aliases for TSACC Gene

  • TSSK6 Activating Cochaperone 2 3 5
  • SSTK-Interacting Protein 2 4
  • C1orf182 3 4
  • SSTK-IP 3 4
  • TSSK6-Activating Co-Chaperone Protein 3
  • Chromosome 1 Open Reading Frame 182 2
  • SSTK-Interacting Protein (SSTK-IP) 3
  • TSSK6 Activating Co-Chaperone 3
  • SIP 3

External Ids for TSACC Gene

Previous HGNC Symbols for TSACC Gene

  • C1orf182

Summaries for TSACC Gene

GeneCards Summary for TSACC Gene

TSACC (TSSK6 Activating Cochaperone) is a Protein Coding gene. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for TSACC Gene

  • Co-chaperone that facilitates HSP-mediated activation of TSSK6.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSACC Gene

Genomics for TSACC Gene

Regulatory Elements for TSACC Gene

Enhancers for TSACC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TSACC on UCSC Golden Path with GeneCards custom track

Promoters for TSACC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSACC on UCSC Golden Path with GeneCards custom track

Genomic Location for TSACC Gene

Chromosome:
1
Start:
156,337,314 bp from pter
End:
156,346,995 bp from pter
Size:
9,682 bases
Orientation:
Plus strand

Genomic View for TSACC Gene

Genes around TSACC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSACC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSACC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSACC Gene

Proteins for TSACC Gene

  • Protein details for TSACC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A04-TSACC_HUMAN
    Recommended name:
    TSSK6-activating co-chaperone protein
    Protein Accession:
    Q96A04
    Secondary Accessions:
    • D3DVB9

    Protein attributes for TSACC Gene

    Size:
    125 amino acids
    Molecular mass:
    13670 Da
    Quaternary structure:
    • Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90.

neXtProt entry for TSACC Gene

Post-translational modifications for TSACC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSACC Gene

Domains & Families for TSACC Gene

Protein Domains for TSACC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSACC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A04

UniProtKB/Swiss-Prot:

TSACC_HUMAN :
  • Belongs to the TSACC family.
Family:
  • Belongs to the TSACC family.
genes like me logo Genes that share domains with TSACC: view

No data available for Gene Families for TSACC Gene

Function for TSACC Gene

Molecular function for TSACC Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that facilitates HSP-mediated activation of TSSK6.

Gene Ontology (GO) - Molecular Function for TSACC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051087 chaperone binding IPI 20829357
genes like me logo Genes that share ontologies with TSACC: view

Phenotypes for TSACC Gene

genes like me logo Genes that share phenotypes with TSACC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSACC Gene

Localization for TSACC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSACC Gene COMPARTMENTS Subcellular localization image for TSACC gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TSACC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSACC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSACC Gene

Pathways & Interactions for TSACC Gene

SuperPathways for TSACC Gene

No Data Available

Interacting Proteins for TSACC Gene

Gene Ontology (GO) - Biological Process for TSACC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TSACC Gene

Drugs & Compounds for TSACC Gene

No Compound Related Data Available

Transcripts for TSACC Gene

Unigene Clusters for TSACC Gene

TSSK6 activating co-chaperone:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSACC Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - -

Relevant External Links for TSACC Gene

GeneLoc Exon Structure for
TSACC
ECgene alternative splicing isoforms for
TSACC

Expression for TSACC Gene

mRNA expression in normal human tissues for TSACC Gene

mRNA differential expression in normal tissues according to GTEx for TSACC Gene

This gene is overexpressed in Testis (x50.3).

NURSA nuclear receptor signaling pathways regulating expression of TSACC Gene:

TSACC

SOURCE GeneReport for Unigene cluster for TSACC Gene:

Hs.534539

mRNA Expression by UniProt/SwissProt for TSACC Gene:

Q96A04-TSACC_HUMAN
Tissue specificity: Expressed in testis but is absent from mature sperm.
genes like me logo Genes that share expression patterns with TSACC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TSACC Gene

Orthologs for TSACC Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSACC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSACC 34
  • 89.16 (n)
  • 81.3 (a)
TSACC 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsacc 34
  • 75.54 (n)
  • 60.48 (a)
Tsacc 16
Tsacc 35
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsacc 34
  • 80.91 (n)
  • 71.77 (a)
oppossum
(Monodelphis domestica)
Mammalia TSACC 35
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf182 35
  • 98 (a)
OneToOne
C1H1orf182 34
  • 98.93 (n)
  • 98.4 (a)
Species where no ortholog for TSACC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSACC Gene

ENSEMBL:
Gene Tree for TSACC (if available)
TreeFam:
Gene Tree for TSACC (if available)

Paralogs for TSACC Gene

No data available for Paralogs for TSACC Gene

Variants for TSACC Gene

Sequence variations from dbSNP and Humsavar for TSACC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs41265043 - 156,344,706(+) GCCCT(C/T)GGGTA intron-variant, reference, missense
rs2025577 -- 156,344,313(-) TACAT(A/G)AGATG intron-variant
rs2274226 -- 156,344,836(-) AGCTA(C/T)CACGG intron-variant
rs2764409 -- 156,343,735(-) AACAA(A/C)AAAAA intron-variant
rs7545042 -- 156,340,553(+) gcctc(A/C)cgggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSACC Gene

Variant ID Type Subtype PubMed ID
esv3587635 CNV gain 21293372

Variation tolerance for TSACC Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSACC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSACC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSACC Gene

Disorders for TSACC Gene

Relevant External Links for TSACC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSACC

No disorders were found for TSACC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSACC Gene

Publications for TSACC Gene

  1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. (PMID: 20829357) Jha K.N. … Johnson G.R. (J. Biol. Chem. 2010) 2 3 4 65
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 65

Products for TSACC Gene

Sources for TSACC Gene

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