TSACC Gene
protein-coding GIFtS: 37
GCID: GC01P156308
|
|
TSSK6 activating co-chaperone(Previous name: chromosome 1 open reading frame 182 )
(Previous symbol: C1orf182)
| |
Aliases
for TSACC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TSSK6 Activating Co-Chaperone1 2 | | RP11-443G18.52 | | C1orf1821 2 3 | | SSTK-Interacting Protein (SSTK-IP)2 | | SSTK-IP1 2 3 | | TSSK6-Activating Co-Chaperone Protein2 | | SIP1 2 | | SSTK-Interacting Protein3 | | Chromosome 1 Open Reading Frame 1821 | | |
Export aliases for TSACC gene to outside databases |
Summaries
for TSACC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04Function: Co-chaperone that facilitates HSP-mediated activation of TSSK6
|
Genomic Views
for TSACC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TSACC
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSACC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSACC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22TSACC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P156308: view genomic region
(about GC identifiers)
Start:
|
156,307,105 bp from pter |
End:
|
156,316,786 bp from pter |
Size:
|
9,682 bases |
Orientation:
|
plus strand |
|
Proteins
for TSACC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04 (See
protein sequence)Recommended Name: TSSK6-activating co-chaperone protein Size: 125 amino acids; 13670 Da
Subunit: Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruitsTSACC to HSP90
Secondary accessions: D3DVB9Explore the universe of human proteins at neXtProt for TSACC: NX_Q96A04
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96A04
TSACC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653228.1
ENSEMBL proteins: ENSP00000357238 ENSP00000357237 ENSP00000357236 ENSP00000357235 ENSP00000357234
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
TSACC for ontologies About GeneDecksing
TSACC Antibody Products:
Assay Products for TSACC: |
Protein
Domains /
Families
for TSACC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96A04 UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04Similarity: Belongs to the TSACC family |
Function
for TSACC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04Function: Co-chaperone that facilitates HSP-mediated activation of TSSK6
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSACC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSACC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TSACC | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSACC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSACC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSACC |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051087 | chaperone binding |
IPI | -- |
TSACC for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TSACC:
|
Pathways & Interactions
for TSACC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSACC
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for TSACC (Q96A043 ENSP000003572344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TSACC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSACC
Search CenterWatch for drugs/clinical trials and news about TSACC
|
Transcripts
for TSACC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSACC gene: NM_144627.3 Unigene Cluster for TSACC: TSSK6 activating co-chaperone Hs.534539 [show with all ESTs]Unigene Representative Sequence: BQ0721658 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368255(uc001foo.3) ENST00000470342 ENST00000368254(uc009wry.3 uc001fop.4)
ENST00000368253 ENST00000481479 ENST00000368252 ENST00000466306 ENST00000368251
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSACC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSACC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TSACC | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSACC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSACC |
Additional cDNA sequence: AK311950.1 AY048672.1 AY048673.1 BC014605.1 7 DOTS entries: DT.407046 DT.95267354 DT.95143909 DT.121427059 DT.95363251 DT.121427060 DT.95363250 24/63 AceView cDNA sequences (see all 63): AY048672 AI967930 AI041198 AY048673 BI831108 AI336861 BE502639 AI635425 BF059194 BQ072165 BG724435 BF057190 AI968690 BP371141 BE464129 AI918858 AI917341 BI826537 BI463044 BP369155 AI990328 BC014605 BP370995 BE550351
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TSACC (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for TSACC
|
Expression
for TSACC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TSACC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSACC
SOURCE GeneReport for Unigene cluster: Hs.534539
UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04Tissue specificity: Expressed in testis but is absent from mature sperm
SABiosciences Custom PCR Arrays for TSACC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSACC
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TSACC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSACC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSACC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSACC |
Orthologs
for TSACC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for TSACC gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tsacc1 , 5 |
RIKEN cDNA 1700021C14 gene5
TSSK6 activating co-chaperone1 |
75.54(n)1
60.48(a)1 |
|
3 (38.79 cM)5
769271 NM_029801.21 NP_084077.11
882827575 |
ENSEMBL Gene Tree for TSACC (if available)
TreeFam Gene Tree for TSACC (if available) |
Paralogs
for TSACC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TSACC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSACC (156307105 - 156316786 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSACC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSACC |
|
Disorders
/ Diseases
for TSACC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TSACC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSACC gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSACC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel HSP70-binding cochaperone c ritical to HSP90-mediated activation of small serine/threonine kinase. (PubMed id 20829357)1, 2, 3 Jha K.N....Johnson G.R. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TSACC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSACC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSACC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSACC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSACC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSACC gene:
Search GeneIP for patents involving TSACC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSACC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSACC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSACC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSACC | | | OriGene Protein Over-expression Lysate for TSACC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSACC | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSACC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSACC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSACC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSACC | | OriGene Custom Protein Services for TSACC | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSACC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSACC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSACC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSACC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSACC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSACC |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TSACC |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TSACC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSACC |
|  |  |  | | | | ThermoFisher Antibody for TSACC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSACC |
|
|
|
|
