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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSACC Gene

protein-coding   GIFtS: 35
GCID: GC01P156308

TSSK6 Activating Co-Chaperone

(Previous name: chromosome 1 open reading frame 182)
(Previous symbol: C1orf182)
  Search for TSACC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TSSK6 Activating Co-Chaperone1 2     RP11-443G18.52
C1orf1821 2 3     SIP2
SSTK-Interacting Protein1 3     SSTK-Interacting Protein (SSTK-IP)2
SSTK-IP2 3     TSSK6-Activating Co-Chaperone Protein2
Chromosome 1 Open Reading Frame 1821     

External Ids:    HGNC: 306361   Entrez Gene: 1282292   Ensembl: ENSG000001634677   UniProtKB: Q96A043   

Export aliases for TSACC gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSACC Gene: 
TSACC (TSSK6 activating co-chaperone) is a protein-coding gene. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04
Function: Co-chaperone that facilitates HSP-mediated activation of TSSK6




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TSACC
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TSACC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSACC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

TSACC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSACC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156308:  view genomic region     (about GC identifiers)

Start:
156,307,105 bp from pter      End:
156,316,786 bp from pter
Size:
9,682 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04 (See protein sequence)
Recommended Name: TSSK6-activating co-chaperone protein  
Size: 125 amino acids; 13670 Da
Subunit: Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and
recruits TSACC to HSP90
Secondary accessions: D3DVB9

Explore the universe of human proteins at neXtProt for TSACC: NX_Q96A04

Explore proteomics data for TSACC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A04

  • TSACC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSACC Protein Expression
    REFSEQ proteins: NP_653228.1  
    ENSEMBL proteins: 
     ENSP00000357238   ENSP00000357237   ENSP00000357236   ENSP00000357235   ENSP00000357234  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    TSACC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96A04

    UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04
    Similarity: Belongs to the TSACC family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSACC_HUMAN, Q96A04
    Function: Co-chaperone that facilitates HSP-mediated activation of TSSK6

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051087chaperone binding IPI--
         
    TSACC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSACC:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSACC 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSACC

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TSACC (Q96A043 ENSP000003572344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNBO609413, ENSP000003840844I2D: score=2 STRING: ENSP00000384084
    --Q96AW03I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSACC

    Search CenterWatch for drugs/clinical trials and news about TSACC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSACC gene: 
    NM_144627.3  

    Unigene Cluster for TSACC:

    TSSK6 activating co-chaperone
    Hs.534539  [show with all ESTs]
    Unigene Representative Sequence: BQ072165
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368255(uc001foo.3) ENST00000470342 ENST00000368254(uc009wry.3 uc001fop.4)
    ENST00000368253 ENST00000481479 ENST00000368252 ENST00000466306 ENST00000368251

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    Inhib. RNA
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    Additional mRNA sequence: 

    AK311950.1 AY048672.1 AY048673.1 BC014605.1 

    7 DOTS entries:

    DT.407046  DT.95267354  DT.95143909  DT.121427059  DT.95363251  DT.121427060  DT.95363250 

    24/63 AceView cDNA sequences (see all 63):

    AY048673 BF059194 BG724435 AI336861 AI041198 AI967930 AI635425 BF057190 
    BE502639 AY048672 BI831108 BQ072165 BI829345 AA609860 BG192532 AI968690 
    BG150462 AI652939 BE550351 BC014605 BP369694 BP370995 BP369976 BE464129 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TSACC (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:        -     -     -     -     -     -     -                                       
    SP2:                                -     -     -     -                                 
    SP3:                                -     -     -     -                 -               
    SP4:                                -     -     -                                       
    SP5:                                -     -     -                       -               


    ECgene alternative splicing isoforms for TSACC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See TSACC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSACC

    SOURCE GeneReport for Unigene cluster: Hs.534539

    UniProtKB/Swiss-Prot: TSACC_HUMAN, Q96A04
    Tissue specificity: Expressed in testis but is absent from mature sperm

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TSACC gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsacc1 , 5 RIKEN cDNA 1700021C14 gene5
    TSSK6 activating co-chaperone1
    75.54(n)1
    60.48(a)1
      3 (38.79 cM)5
    769271  NM_029801.21  NP_084077.11 
     882827575 


    ENSEMBL Gene Tree for TSACC (if available)
    TreeFam Gene Tree for TSACC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 SNPs in TSACC are shown (see all 122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824359321,2
    --156310307(+) GAGTGC/TAGTGG 1 -- int10--------
    rs1870648211,2
    --156310329(+) CTCACC/TGCAAC 1 -- int10--------
    rs75450421,2
    C--156310344(+) gcctcA/Ccgggt 1 -- int10--------
    rs1139175681,2
    F--156310357(+) AAGCAG/ATTCTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1871032531,2
    C--156310377(+) CTTCCC/TGAGTA 1 -- int10--------
    rs1470514221,2
    C--156310397(+) GCAGGC/TGTGCA 1 -- int10--------
    rs1900915481,2
    --156310627(+) GAGTCA/TACAGG 1 -- int10--------
    rs1382271951,2
    --156310836(+) CTCCTA/GGCCTC 1 -- int10--------
    rs1823357341,2
    --156310849(+) GTGATC/GCGCCC 1 -- int10--------
    rs1878978381,2
    --156310850(+) TGATCC/GGCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TSACC (156307105 - 156316786 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSACC: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSACC
    DNA2.0 Custom Variant and Variant Library Synthesis for TSACC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSACC gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TSACC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel HSP70-binding cochaperone c ritical to HSP90-mediated activation of small serine/threonine kinase. (PubMed id 20829357)1, 2, 3 Jha K.N....Johnson G.R. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    5. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1 Kamatani Y....Kamatani N. (2010)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 128229 HGNC: 30636 AceView: SSTK-IP Ensembl:ENSG00000163467 euGenes: HUgn128229
    ECgene: TSACC H-InvDB: TSACC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSACC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSACC gene:
    Search GeneIP for patents involving TSACC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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