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Aliases for TSACC Gene

Aliases for TSACC Gene

  • TSSK6 Activating Co-Chaperone 2 3
  • SSTK-Interacting Protein 2 4
  • C1orf182 3 4
  • SSTK-IP 3 4
  • TSSK6-Activating Co-Chaperone Protein 3
  • Chromosome 1 Open Reading Frame 182 2
  • SSTK-Interacting Protein (SSTK-IP) 3
  • SIP 3

External Ids for TSACC Gene

Previous HGNC Symbols for TSACC Gene

  • C1orf182

Summaries for TSACC Gene

GeneCards Summary for TSACC Gene

TSACC (TSSK6 Activating Co-Chaperone) is a Protein Coding gene. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for TSACC Gene

  • Co-chaperone that facilitates HSP-mediated activation of TSSK6.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSACC Gene

Genomics for TSACC Gene

Genomic Location for TSACC Gene

Start:
156,337,314 bp from pter
End:
156,346,995 bp from pter
Size:
9,682 bases
Orientation:
Plus strand

Genomic View for TSACC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSACC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSACC Gene

No data available for Regulatory Elements for TSACC Gene

Proteins for TSACC Gene

  • Protein details for TSACC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A04-TSACC_HUMAN
    Recommended name:
    TSSK6-activating co-chaperone protein
    Protein Accession:
    Q96A04
    Secondary Accessions:
    • D3DVB9

    Protein attributes for TSACC Gene

    Size:
    125 amino acids
    Molecular mass:
    13670 Da
    Quaternary structure:
    • Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90.

neXtProt entry for TSACC Gene

Proteomics data for TSACC Gene at MOPED

Post-translational modifications for TSACC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSACC Gene

Domains for TSACC Gene

Protein Domains for TSACC Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96A04

UniProtKB/Swiss-Prot:

TSACC_HUMAN :
  • Q96A04
Family:
  • Belongs to the TSACC family.
genes like me logo Genes that share domains with TSACC: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TSACC Gene

Function for TSACC Gene

Molecular function for TSACC Gene

UniProtKB/Swiss-Prot Function: Co-chaperone that facilitates HSP-mediated activation of TSSK6.

Gene Ontology (GO) - Molecular Function for TSACC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051087 chaperone binding IPI 20829357
genes like me logo Genes that share ontologies with TSACC: view

Phenotypes for TSACC Gene

GenomeRNAi human phenotypes for TSACC:
genes like me logo Genes that share phenotypes with TSACC: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSACC Gene

Localization for TSACC Gene

Gene Ontology (GO) - Cellular Components for TSACC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSACC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TSACC Gene

Pathways for TSACC Gene

SuperPathways for TSACC Gene

No Data Available

Interacting Proteins for TSACC Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357234%0d%0a9606.ENSP00000384084%0d%0a9606.ENSP00000386200%0d%0a
Selected Interacting proteins: ENSP00000357234 Q96A04-TSACC_HUMAN for TSACC Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for TSACC Gene

None

No data available for Pathways by source for TSACC Gene

Transcripts for TSACC Gene

Unigene Clusters for TSACC Gene

TSSK6 activating co-chaperone:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSACC Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - -

Relevant External Links for TSACC Gene

GeneLoc Exon Structure for
TSACC
ECgene alternative splicing isoforms for
TSACC

Expression for TSACC Gene

mRNA expression in normal human tissues for TSACC Gene

mRNA differential expression in normal tissues according to GTEx for TSACC Gene

This gene is overexpressed in Testis (50.3).

SOURCE GeneReport for Unigene cluster for TSACC Gene Hs.534539

mRNA Expression by UniProt/SwissProt for TSACC Gene

Q96A04-TSACC_HUMAN
Tissue specificity: Expressed in testis but is absent from mature sperm.
genes like me logo Genes that share expressions with TSACC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for TSACC Gene

Orthologs for TSACC Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSACC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf182 35
  • 98.93 (n)
  • 98.4 (a)
C1H1orf182 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSACC 35
  • 89.16 (n)
  • 81.3 (a)
TSACC 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsacc 35
  • 75.54 (n)
  • 60.48 (a)
Tsacc 16
Tsacc 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSACC 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsacc 35
  • 80.91 (n)
  • 71.77 (a)
Species with no ortholog for TSACC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSACC Gene

ENSEMBL:
Gene Tree for TSACC (if available)
TreeFam:
Gene Tree for TSACC (if available)

Paralogs for TSACC Gene

No data available for Paralogs for TSACC Gene

Variants for TSACC Gene

Sequence variations from dbSNP and Humsavar for TSACC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2025577 -- 156,344,313(-) TACAT(A/G)AGATG intron-variant
rs2274226 -- 156,344,836(-) AGCTA(C/T)CACGG intron-variant
rs2764409 -- 156,343,735(-) AACAA(A/C)AAAAA intron-variant
rs7545042 -- 156,340,553(+) gcctc(A/C)cgggt intron-variant
rs11553713 -- 156,346,816(+) GTATG(C/T)AAACC reference, missense

Relevant External Links for TSACC Gene

HapMap Linkage Disequilibrium report
TSACC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSACC Gene

Disorders for TSACC Gene

No disorders were found for TSACC Gene.

No data available for UniProtKB/Swiss-Prot for TSACC Gene

Publications for TSACC Gene

  1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. (PMID: 20829357) Jha K.N. … Johnson G.R. (J. Biol. Chem. 2010) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for TSACC Gene

Sources for TSACC Gene

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